Freeze-drying Patents (Class 34/284)
  • Patent number: 11112176
    Abstract: A freeze vacuum drying apparatus includes: a spraying unit; a pipe unit; a heating unit; and a collection unit. The spraying unit sprays a raw material liquid into a vacuum chamber. The pipe unit has a non-linear shape, includes a first opening end and a second opening end, and traps frozen particles via the first opening end, the frozen particles being formed by self-freezing of liquid droplets formed by spraying the raw material liquid into the vacuum chamber. The heating unit heats the frozen particles in the pipe unit for sublimation drying, the frozen particles moving in the pipe unit from the first opening end toward the second opening end by kinetic energy produced during spraying. The collection unit collects dried particles that are formed by sublimation drying of the frozen particles in the pipe unit and released from the second opening end of the pipe unit.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: September 7, 2021
    Assignee: ULVAC, INC.
    Inventors: Tsutomu Nishihashi, Haruhisa Nakano, Hirohiko Murakami, Tsuyoshi Yoshimoto, Masaki Itou, Takumi Komiya
  • Patent number: 11094565
    Abstract: Disclosed is a substrate treating method of performing drying treatment on a pattern-formed surface of a substrate, the substrate treating method comprising: a supplying step of supplying a substrate treating liquid containing a plastic crystalline material in a molten state to the pattern-formed surface of the substrate; a plastic crystalline layer forming step of bringing, on the pattern-formed surface, the plastic crystalline material into a state of a plastic crystal so as to form a plastic crystalline layer; and a removing step of changing the plastic crystalline material in the state of the plastic crystal into a gas state without an intermediate phase of liquid so as to remove the plastic crystalline material from the pattern-formed surface.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: August 17, 2021
    Inventors: Yuta Sasaki, Yosuke Hanawa
  • Patent number: 11035613
    Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: June 15, 2021
    Assignee: Gen-Probe Incorporated
    Inventor: Byron J. Knight
  • Patent number: 10927423
    Abstract: A method for processing skin, the method comprising freezing of the skin before freeze-drying this, freeze-drying of the skin and application of an impregnation material into the freeze-dried skin.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: February 23, 2021
    Inventors: Piet Van Quathem, Frank Vancauwenberghe
  • Patent number: 10782070
    Abstract: Disclosed herein are embodiments of an energy recovery system for a freeze-drying system. In some embodiments, the freeze-drying system includes a freeze dryer chamber having one or more shelves disposed therein; a refrigeration system comprising a refrigerant condenser; a heat exchanger; a first fluid line to thermally couple the refrigerant condenser to the heat exchanger; and a second fluid line to thermally couple the one or more shelves to the heat exchanger.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: September 22, 2020
    Assignee: SP Industries, Inc.
    Inventor: Charles D. Dern
  • Patent number: 10632215
    Abstract: Described are a device and a method for rapidly sterilizing liquid nitrogen in a container using ultraviolet radiation irradiated for a predetermined length of time based on the temperature measured by a sensor and on the minimum dose of radiation necessary to kill micro-organisms resistant to liquid nitrogen.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: April 28, 2020
    Assignee: NTERILIZER S.R.L.
    Inventor: Lodovico Parmegiani
  • Patent number: 10443935
    Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 15, 2019
    Assignee: Gen-Probe Incorporated
    Inventor: Byron J. Knight
  • Patent number: 10415881
    Abstract: The present invention discloses a method for freeze-drying drug liposomes powder assisted by a variable-frequency alternating-current electric field, which includes the following steps: (1) preparing a drug-liposome suspension sample; (2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current; (3) freezing and drying the sample treated in step (2) at ?20° C. to ?40° C., under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, until completion of the freezing process; and (4) heating and drying the sample in a vacuum until completion of sublimation and desorption, and obtaining the drug liposomes freeze-dried powder. The present invention not only greatly shortens a freezing and drying time, but also controls a size of nuclei and ice crystals, further ensuring a quality of the freeze-dried powder.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: September 17, 2019
    Assignee: South China University of Technology
    Inventors: Dawen Sun, Lina Cheng, Zhiwei Zhu, Xin'an Zeng, Qijun Wang, Zi Zhang
  • Patent number: 10041730
    Abstract: A vacuum system, such as the form of a plasma system, includes a vacuum chamber. The side walls of the vacuum chamber are configured in the form of a completely closed chamber extruded profile. A first end face of the chamber extruded profile is closed off with a plate. A second end face of the chamber extruded profile, which lies opposite the first end face, has a reversibly openable and closable door. The door is fastened by at least one hinge pivotably to the chamber extruded profile. The side walls, which are fully closed transversely to the longitudinal axis of the chamber extruded profile, enable a simple and cost-effective production of the vacuum chamber. The vacuum chamber may be accommodated at least partially in a housing, which may likewise be configured at least partially in the form of an extruded profile.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: August 7, 2018
    Inventor: Christof-Herbert Diener
  • Patent number: 10023857
    Abstract: An apparatus and method for dehydrating biological materials, such as vaccines and microorganism cultures, in which the materials are dehydrated in an evacuated container which is in a microwave waveguide that is open to the atmosphere. The apparatus comprises means for freezing the container of biological material, a microwave generator, a waveguide, means for introducing the container into the waveguide, means for applying a vacuum to the container and means for removing the dehydrated material from the waveguide. In the method of the invention, the container of biological material is put in a microwave waveguide open to the atmosphere, a vacuum is applied to the container, the material is frozen and is radiated to dehydrate it. The dehydrated material is then removed from the waveguide.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: July 17, 2018
    Assignee: EN WAVE CORPORATION
    Inventors: Timothy D. Durance, Jun Fu, Parastoo Yaghmaee, Robert L. Pike
  • Patent number: 10011381
    Abstract: Disclosed is a process for the treatment or processing of containers that serve for storing, or contain, substances for medical, pharmaceutical or cosmetic applications, wherein the containers are conveyed automatically, by a conveyor, past at least one processing station or pass it for the treatment or processing. In the process, a plurality of containers is conveyed by the conveyor while being held by a carrier in a regular arrangement. The containers held on the carrier are raised to a raised position for the treatment or processing at or in the respective processing station and are lowered after the treatment or processing, to be held again on the carrier in the regular arrangement. The carrier is configured such that the containers can be held on the carrier during the entire process. A negative pressure acts on the bottoms of the containers in order to lower them.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: July 3, 2018
    Assignee: SCHOTT AG
    Inventors: Gregor Fritz Deutschle, Joern Wassenberg, Alexander Wansel, Kai Wissner
  • Patent number: 9963259
    Abstract: Disclosed is a process for the treatment or processing of containers that serve for storing, or contain, substances for medical, pharmaceutical or cosmetic applications, wherein the containers are conveyed automatically, by a conveyor, past at least one processing station or pass it for the treatment or processing. In the process, a plurality of containers is conveyed by the conveyor while being held by a carrier in a regular arrangement. The containers held on the carrier are raised to a raised position for the treatment or processing at or in the respective processing station and are lowered after the treatment or processing, to be held again on the carrier in the regular arrangement. The carrier is configured such that the containers can be held on the carrier during the entire process. A negative pressure acts on the bottoms of the containers in order to lower them.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 8, 2018
    Assignee: SCHOTT AG
    Inventors: Gregor Fritz Deutschle, Joern Wassenberg, Alexander Wansel, Kai Wissner
  • Patent number: 9879909
    Abstract: A method to monitor a secondary drying phase of a freeze-drying process comprises initial steps in which is provided to perform pressure rise tests at different time and to calculate a respective value of experimental desorption rate of product (steps 1 to 3). Subsequently, the method provides to estimate initial conditions and kinetic constants of a kinetic model of the process (step 4) and to calculate at time t=t2 a respective residual moisture content and a respective desorption rate (step 5). The method can be performed in a freeze-dryer apparatus which includes a drying chamber that contains a product to be dried and can be isolated to perform pressure rise tests.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: January 30, 2018
    Assignee: TELSTAR TECHNOLOGIES, S.L.
    Inventors: Davide Fissore, Antonello Barresi, Roberto Pisano
  • Patent number: 9616125
    Abstract: A stable and lyophilized pharmaceutical agent containing nocathiacin, which is prepared by lyophilizing a liquid formulation of nocathiacin, a stabilizer, an excipient, a pH regulator and injectable water, wherein the stabilizer is selected from polyethylene glycol, polysorbate or a mixture thereof, and the pH value of the liquid formulation is 1.0-6.0 is provided.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: April 11, 2017
    Assignee: NANJING BIOTICA PHARMACEUTICAL COMPANY
    Inventor: Yijun Chen
  • Patent number: 9591863
    Abstract: The present invention provides a foaming instant coffee composition comprising particles having a bulk density of from 0.16 to 0.45 g/cm3, said particles comprising a continuous phase comprising an instant coffee matrix and a non-continuous phase comprising particles of a foamable component containing a gas.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: March 14, 2017
    Assignee: Kraft Foods R & D, Inc.
    Inventor: Thomas Philip Imison
  • Patent number: 9540154
    Abstract: A closure (1) for a container (9), or for an ampoule (9), in which a medicament is accommodated, having a closure cap (2) and a closure stopper (5) accommodated in the closure (2). Detent moldings (6) are formed on the closure cap (2) for latchingly holding the closure (1) on the ampoule (9), and a sliding part (3) is provided which is movable relative to the closure cap (2) in order to displace the closure stopper (5) into the closed position. In order to advantageously provide, with respect to carrying out a freeze-drying process, a closure for a container, or for an ampoule, in which a medicament is accommodated, the closure stopper (5) is displaceable relative to the cap (2) by means of the sliding part (3) in order to move the closure stopper into the closed position. There is also a method for carrying out a freeze-drying process for a medium, or for a medicament, which is accommodated in a container, or in an ampoule (9).
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: January 10, 2017
    Assignee: Datwyler Pharma Packaging International NV
    Inventors: Ronny Prosper Elisabeth Vrijens, Reinhard Louis Jozef Waeben
  • Patent number: 9528761
    Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: December 27, 2016
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Wei-Youh Kuu, Mark Doty, William S. Hurst, Christine L. Rebbeck
  • Patent number: 9399012
    Abstract: Described herein are compositions and methods for intravenous administration of acetaminophen at a single dose level of less than about 1000 mg for the treatment or prevention of pain (e.g., postoperative pain) and/or fever.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: July 26, 2016
    Assignee: MALLINCKRODT IP
    Inventors: Mike Allan Royal, James Bradley Breitmeyer
  • Patent number: 9052138
    Abstract: A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: June 9, 2015
    Assignee: IMA LIFE NORTH AMERICA INC.
    Inventors: Francis W. DeMarco, Ernesto Renzi
  • Publication number: 20150101208
    Abstract: The invention provides a monitoring device (32) for a dryer (10) includes a means for sensing a physical parameter, such as temperature or strain, at a sensing locus within the dryer (10), for example at a vial (20). The sensing means comprises an optical sensing fiber (38) having at least one fiber Bragg grating (54). Moreover, the invention provides a dryer, in particular a freeze dryer (10), which is equipped with such monitoring device (32).
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Inventors: Wolfgang Friess, Manfred Resch, Michael Wiggenhorn
  • Publication number: 20150093560
    Abstract: A porous body that contains cellulose nanofibers having very thin fiber diameters and high hydrophilicity, and has a large specific surface area, and to provide a method of producing the porous body simply with low cost. A method of producing a porous cellulose comprises a process of lyophilizing a mixed liquid containing cellulose nanofibers and a dispersion medium, wherein the dispersion medium is a mixed dispersion medium of water and an organic solvent dissolving in water, a concentration of the organic solvent in the mixed dispersion medium is 2 to 40 mass %, and a solid content concentration of the cellulose nanofibers in the mixed liquid is 0.001 to 5 mass %.
    Type: Application
    Filed: May 15, 2013
    Publication date: April 2, 2015
    Applicants: THE UNIVERSITY OF TOKYO, HOKUETSU KISHU PAPER CO., LTD.
    Inventors: Junji Nemoto, Toshihiko Soyama, Akira Isogai, Tsuguyuki Saito
  • Publication number: 20150089830
    Abstract: In a process and apparatus for treating or processing containers (2) that are used for storing substances for medical, pharmaceutical or cosmetic applications or contain the same, cylindrical containers open at least at one end are automatically led past or pass through processing stations for treatment or processing by means of a conveying device, while said containers are jointly held by a carrier (25; 134) in a regular two-dimensional arrangement. The carrier comprises a plurality of openings or receptacles (32; 39; 87; 120), which determine the regular arrangement. According to the invention, the treatment or processing of the containers is performed on or in at least one of the processing stations while the containers are supported by the carrier. This opens up new possibilities for treating or processing the containers, for example when crimping metal lids or during freeze-drying.
    Type: Application
    Filed: May 2, 2013
    Publication date: April 2, 2015
    Inventors: Kai Wissner, Edgar Pawlowski, Gregor Fritz Deutschle, Kristopher Koch
  • Patent number: 8951565
    Abstract: Improved hemostatic agents take the form of granules or particles that can be used to stanch, seal, or stabilize a site of hemorrhage, including a noncompressible hemorrhage.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: February 10, 2015
    Assignee: HemCon Medical Technologies, Inc.
    Inventor: Simon J. McCarthy
  • Patent number: 8950609
    Abstract: A stopper device including a stopper, cap and ring provided with tabs for locking onto a container neck and a body for handling the ring. The body includes a first mechanism for transmitting a thrust force to the ring and a second mechanism for activating the tabs. The ring and the handling body are respectively provided with first and second retainers that hold the handling body in a waiting position. The handling body is mobile parallel to the thrust force direction and in relation to the ring, between a first position activating the tabs of the ring and is mobile in translation only in the thrust force direction, and a second position that also activates the tabs and is immobilized in relation to the ring in axial translation. The tabs extend from a continuous edge of the ring and are each arranged in an opening with a closed contour.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: February 10, 2015
    Assignee: West Pharmaceutical Services Deutschland GmbH & Co. KG
    Inventor: Antoine Aneas
  • Publication number: 20150025080
    Abstract: The present invention provides processes for the preparation of amorphous form of sitagliptin dihydrogen phosphate. It also provides a solid dispersion of sitagliptin dihydrogen phosphate, including in the amorphous form, and processes for its preparation.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 22, 2015
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Poonam Kaushik, Ram Thaimattam, Mohan Prasad, Sudershan Kumar Arora
  • Publication number: 20140373382
    Abstract: A method of monitoring and controlling a freeze drying process in a freeze drying apparatus having walls, shelves and a number of vials or trays positioned on different areas of the shelves and containing product to be freeze dried. One or more vials or trays are selected that are representative of the positions of all of the vials or trays in different areas of the shelves. One or more heat flux sensors are positioned between the selected vials or trays and adjacent portions of the walls and/or shelves. The heat transfer between the selected vials or trays and the adjacent wall or shelf portions is measured during the freezing and drying stages of the freeze drying process.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 25, 2014
    Inventor: Weijia LING
  • Patent number: 8898928
    Abstract: An apparatus for delamination drying a substrate is provided. A chamber for receiving a substrate is provided. A chuck supports and clamps the substrate within the chamber. A temperature controller controls the temperature of the substrate and is able to cool the substrate. A vacuum pump is in fluid connection with the chamber. A tilting mechanism is able to tilt the chuck at least 90 degrees.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: December 2, 2014
    Assignee: Lam Research Corporation
    Inventors: Stephen M. Sirard, Diane Hymes, Alan M. Schoepp, Ratchana Limary
  • Patent number: 8895756
    Abstract: The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides methods of producing lyophilized bendamustine. The pharmaceutical formulations can be used for any disease that is sensitive to treatment with bendamustine, such as neoplastic diseases.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: November 25, 2014
    Assignee: Cephalon, Inc.
    Inventors: Jason Edward Brittain, Joe Craig Franklin
  • Publication number: 20140325868
    Abstract: System and method for lyophilization or freeze-drying is provided. During the freezing step, the material or solution to be frozen is initially brought to a temperature near or below its freezing temperature after which the pressure in the freeze-dryer chamber is reduced to induce nucleation of the material.
    Type: Application
    Filed: July 18, 2014
    Publication date: November 6, 2014
    Inventors: Theodore Hall Gasteyer, III, Robert Rex Sever, Balazs Hunek, Nigel Grinter, Melinda Lee Verdone
  • Patent number: 8857073
    Abstract: Vacuum concentrator, comprising a vacuum chamber with a closure which may be sealed in an airtight manner, a centrifuge rotor arranged in the vacuum chamber with at least one receiver for at least one vessel for samples to be dried, a drive motor arranged outside the vacuum chamber for driving the centrifuge rotor, a vacuum pump connected to the vacuum chamber, a tempering device associated with the vacuum chamber for tempering the at least one sample in the vacuum chamber, a pressure sensor associated with the vacuum chamber for detecting the pressure inside the vacuum chamber and an electrical control and evaluating device which is connected to the drive motor, the vacuum pump, the tempering device and the pressure sensor, for detecting the end point of the vacuum concentration by means of the pressures detected by the pressure sensor in the vacuum chamber and terminating the vacuum concentration when the end point is determined.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: October 14, 2014
    Assignee: Eppendorf AG
    Inventors: Frank Ramhold, Klaas Van Den Berghe, Bert-Olaf Grimm, Wolfgang Goemann, Rebecca Hess, Felix Francke
  • Publication number: 20140259724
    Abstract: The inventive device and methods described herein address the introduction of a safe and effective freeze-dried biological product, and particularly a plasma product, to a subject in need thereof. The present invention relates to a multifunctional, staged closure device, which also is described as a lyophilization container for plasma (LCP). The device and methods described herein address how to reproducibly achieve a low moisture and substantially oxygen-free atmosphere within a finally hermetically sealed biocompatible low aspect plastic vessel within a standard shelf-stoppering freeze dryer. The present inventive device and methods provide a freeze-dried plasma product that is fully traceable, preserves the constituent plasma activity, is readily prepared in a sterile fashion, is stable, ensures ease of storage and permits rapid reconstitution and delivery to a patient.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: HemCon Medical Technologies, Inc.
    Inventors: Simon McCarthy, Lisa Buckley, Clint Pepper, Ervelyn Winata, Barry Starkman
  • Publication number: 20140245629
    Abstract: A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.
    Type: Application
    Filed: October 4, 2012
    Publication date: September 4, 2014
    Inventors: Bernhard Luy, Mtthias Plitzko, Manfred Struschka
  • Publication number: 20140230266
    Abstract: A process line (300) for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer (304) for freeze drying the particles, wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation, and the spray chamber (302) is adapted for separation of the liquid droplets from any cooling circuit.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 21, 2014
    Inventors: Bernhard Luy, Matthias Plitzko, Manfred Struschka
  • Publication number: 20140230264
    Abstract: The invention relates to a method of preparation of lamellar porous microstructures and nanostructures of various density based on controlled vacuum freeze-drying of a liquid dispersion of nanoparticles. The liquid dispersion of particles is rapidly freezed into solid state inside a tightly closed volume. In this form it is submitted to vacuum freeze-drying with required rate of sublimation of molecules of a liquid dispersion medium, until their total removal, accompanied by the creation of lamellar microstructures and nanostructures. The orientation of the normal vector of the dominant surface of sublimation interface can be set with regard to the required properties of the final sublimate structure from vertically upwards to vertically downwards. The sublimation rate is adjusted by combination of vacuum depth and external heating of the sublimation interface of the frozen material.
    Type: Application
    Filed: August 29, 2012
    Publication date: August 21, 2014
    Applicant: Vysoka Skola Bánska - Technical University of Ostrava, Centrum Nantechnologil
    Inventor: Richard Dvorský
  • Publication number: 20140230265
    Abstract: A freeze-drying apparatus (1) includes an arrangement of individual product platforms (19) that are supported vertically in a frame (20) in a drying chamber, in which each platform is able to be moved to a shift level, in which lateral guides (20, 21) designed to support a carriage (15) are arranged with a fixed height position, and which cooperate with the guides (16, 18) of a loading and unloading device. All product platforms (19) in the drying chamber can be loaded by repeating this operation cyclically. In order to unload the drying chamber, the arrangement of the product platforms (19) are moved to such a position above the shift level in which the carriage (15) can be moved as far as its rear limit position inside the drying chamber, travelling underneath each loaded product platform (19).
    Type: Application
    Filed: November 3, 2013
    Publication date: August 21, 2014
    Applicant: Martin Christ Gefriertrocknungsanlagen GmbH
    Inventor: Martin Christ
  • Patent number: 8800162
    Abstract: A method for monitoring and/or controlling and a freeze drying process in a freeze dryer apparatus provided with a drying chamber having a temperature-controlled shelf supporting containers of a product to be dried, comprises during a primary drying phase of the freeze drying process the steps of: isolating the drying chamber closing an isolating valve thereof and sensing and collecting pressure values inside the drying chamber for a defined pressure collecting time and a shelf temperature of the temperature-controlled shelf (Step 1); calculating a product temperature of product and a plurality of process/product related parameters (Step 2); calculating a new shelf temperature and a sequence of shelf temperatures up to the end of the primary drying phase, that maximizes a sublimation rate of the product maintaining the product temperature below a maximum allowable product temperature.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: August 12, 2014
    Assignee: Azbil Telstar Technologies, S.L.
    Inventors: Salvatore Velardi, Antonello Barresi
  • Publication number: 20140215845
    Abstract: The invention relates to a method for freeze-drying injectable compositions, in particular pharmaceutical compositions, comprising: A) storing a quantity of a dispersion of an injectable composition in an aqueous dispersion medium in at least one ready-to-use vial, B) rotating the vial at least for a period of time to form a dispersion layer at an inner surface of a circumferential wall of the vial, C) during rotating of the vial according to step B) cooling the vial to form ice crystals at the inner surface of the circumferential wall of the vial, and D) drying the cooled composition to sublime at least a portion of the ice crystals formed in the dispersion by substantially homogeneously heating the circumferential wall of the vial. The invention also relates to a freeze-dried composition obtained by the method according to the invention and a system for freeze-drying injectable compositions, in particular pharmaceutical compositions, in particular by making use of the method according to the invention.
    Type: Application
    Filed: August 27, 2012
    Publication date: August 7, 2014
    Applicant: RHEAVITA B.V.
    Inventor: Jozef Antonius Willem Maria Corver
  • Patent number: 8791270
    Abstract: The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides methods of producing lyophilized bendamustine. The pharmaceutical formulations can be used for any disease that is sensitive to treatment with bendamustine, such as neoplastic diseases.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: July 29, 2014
    Assignee: Cephalon, Inc.
    Inventors: Jason Edward Brittain, Joe Craig Franklin
  • Publication number: 20140190035
    Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously. The as frozen solution then provides a lyophilized cake of the solutes with large and uniform pores.
    Type: Application
    Filed: January 17, 2014
    Publication date: July 10, 2014
    Applicants: BAXTER HEALTHCARE SA, BAXTER INTERNATIONAL INC.
    Inventor: Wei Y. Kuu
  • Patent number: 8722169
    Abstract: A freeze dryer shelf with opposed, parallel first and second plates is disclosed. The plates have at least one flow channel located therebetween for conveying a diathermic fluid between the plates. One of the plates has a surface treated to inhibit the sticking to the shelf of a rubber stopper pressed against that surface during the application of pressure to the stopper to push the stopper into a container.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: May 13, 2014
    Assignee: Ima Life S.r.l.
    Inventor: Jozef Antonius Willem Maria Corver
  • Publication number: 20140101964
    Abstract: An apparatus for delamination drying a substrate is provided. A chamber for receiving a substrate is provided. A chuck supports and clamps the substrate within the chamber. A temperature controller controls the temperature of the substrate and is able to cool the substrate. A vacuum pump is in fluid connection with the chamber. A tilting mechanism is able to tilt the chuck at least 90 degrees.
    Type: Application
    Filed: October 11, 2012
    Publication date: April 17, 2014
    Applicant: Lam Research Corporation
    Inventors: Stephen M. SIRARD, Diane HYMES, Alan M. SCHOEPP, Ratchana LIMARY
  • Patent number: 8689459
    Abstract: Method for spray drying a high-viscosity fluid product using a spraying device, wherein the method comprises projecting the fluid product out of an outflow opening of the spraying device for obtaining droplets of the fluid product, wherein the spraying device is arranged to cause a pressure drop in the fluid product across the outflow opening which is larger than 15 bar and at least partially drying the droplets in a drying medium, such as air, to become particles.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: April 8, 2014
    Assignee: Friesland Brands B.V.
    Inventors: Albert Thijs Poortinga, René Jos Houben
  • Patent number: 8677649
    Abstract: A device for large-scale lyophilization of pharmaceutical solutions in medical hollow bodies, includes a lyophilization device and at least one camera. Images of at least one pharmaceutical solution to be lyophilized are recorded by the at least one camera. The images may be used for controlling and/or monitoring the lyophilization process.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: March 25, 2014
    Assignee: Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg
    Inventors: Frank Böttger, Martin Häuptle
  • Patent number: 8640358
    Abstract: Movement of a slot door of a freeze dryer is driven by a rack and pinion actuator. The actuator is easily sanitized and includes internal elements that are accessible to sanitizing sprays. The pinions are driven by pinion shafts that pass through a seal separating an aseptic area from a non-aseptic area where the drive train is positioned. Only rotary motion is transferred across the aseptic barrier, reducing the need for a bellows or sliding covers, which are difficult to sanitize.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: February 4, 2014
    Assignee: Ima Life North America Inc.
    Inventors: Francis W. DeMarco, Ernesto Renzi
  • Publication number: 20140026434
    Abstract: [Object] To provide a calculation method and calculation device for an average sublimation interface temperature, bottom part temperature, and sublimation rate of the whole to-be-dried material introduced into a drying chamber of a freeze-drying device without contaminating or collapsing the to-be-dried material. [Solution] The present invention is applied to a freeze-drying device that includes a drying chamber DC, a cold trap CT, vacuum adjustment means for adjusting the degree of the vacuum in the drying chamber DC, and a control device CR for automatically controlling the operations of the above elements.
    Type: Application
    Filed: February 8, 2012
    Publication date: January 30, 2014
    Applicant: Kyowa Vacuum Engineering, Ltd.
    Inventors: Hiroyuki Sawada, Kazunori Tonegawa, Hiroshi Hosomi, Ryouji Sunama
  • Publication number: 20140007454
    Abstract: A method and apparatus for the continuous sublimation of a substance includes cascading a material containing a substance capable of sublimation, such as water, between a plurality of trays vertically stacked within a processing zone provided within a processing chamber. A substantially atmospheric environment is maintained within the processing zone at a temperature whereby the substance sublimes forming a sublimate within the environment. The environment containing the sublimate is contacted with a drying agent such as a desiccant to maintain the environment whereby the substance sublimes at substantially atmospheric pressure and at the controlled temperature.
    Type: Application
    Filed: July 24, 2013
    Publication date: January 9, 2014
    Inventor: Edward Weisselberg
  • Patent number: 8609863
    Abstract: The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides methods of producing lyophilized bendamustine. The pharmaceutical formulations can be used for any disease that is sensitive to treatment with bendamustine, such as neoplastic diseases.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: December 17, 2013
    Assignee: Cephalon, Inc.
    Inventors: Jason Edward Brittain, Joe Craig Franklin
  • Patent number: 8603063
    Abstract: A multilayer plastic container for storing lyophilized products includes at least three layers consisting of inner and outer layers having a moisture vapor transmission rate of not more than 0.1 gm mil/100 sq. in.-day at 73° F. and 95% rh, and an intermediate layer of hygroscopic resin construction having a moisture content less than 1000 ppm. The hygroscopic intermediate layer preferably comprises at least 30% of the total thickness of the three layers. The inner and outer layers preferably are of cyclic olefin polymer or cyclic olefin copolymer construction, and the hygroscopic intermediate layer preferably is of amorphous nylon construction. The container preferably is empty and sealed within a secondary container, such as a metallized bag, that is impervious to moisture.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: December 10, 2013
    Assignee: Rexam Healthcare Packaging Inc.
    Inventor: Michael J. Grimm
  • Patent number: 8549768
    Abstract: A method for producing a fog of ice nuclei by introducing a cryogenic fluid and a humid gas stream into a freeze dryer. The cryogenic fluid and humid gas stream will form ice nuclei having a preferred size for introduction into vials contained in the freeze dryer.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: October 8, 2013
    Assignee: Linde Aktiengesellschaft
    Inventors: Prerona Chakravarty, Ron C. Lee
  • Patent number: 8528225
    Abstract: A method and apparatus for the continuous sublimation of a substance includes cascading a material containing a substance capable of sublimation, such as water, between a plurality of trays vertically stacked within a processing zone provided within a processing chamber. A substantially atmospheric environment is maintained within the processing zone at a temperature whereby the substance sublimes forming a sublimate within the environment. The environment containing the sublimate is contacted with a drying agent such as a desiccant to maintain the environment whereby the substance sublimes at substantially atmospheric pressure and at the controlled temperature.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: September 10, 2013
    Assignee: Wyssmont Company Inc.
    Inventor: Edward Weisselberg