Abstract: A corneal endothelial cell imaging apparatus includes an irradiation system, a light receiving system, and a controller. The irradiation system includes a spatial light modulator modulating light from a light source, and is configured to irradiate slit-shaped illumination light toward a cornea by modulating the light using the spatial light modulator. The light receiving system is arranged obliquely to the irradiation system and includes an image sensor receiving reflected light from the cornea. The controller is configured to control the spatial light modulator so as to irradiate the illumination light onto an illumination region on the cornea, and is configured to control the image sensor to set an opening range on a light receiving surface corresponding to the illumination region on the cornea and to capture a light receiving result of reflection component from a corneal endothelium obtained by a light receiving element in the set opening range.

Abstract: There is described an automated slit lamp system for imaging an eye of a patient. The automated slit lamp system generally has: an illuminator emitting an illumination beam towards the eye of the patient during examination, the illuminator being operable to illuminate the eye of the patient in different illumination patterns; a controller communicatively coupled to the illuminator, the controller controlling the illuminator to automatically illuminate the eye of the patient with a sequence of illumination patterns comprising at least a first illumination pattern and a second illumination pattern being different from the first illumination pattern, the first and second illumination patterns being selected from a group comprising: diffuse illumination, direct focal illumination, tangential illumination, retroillumination, indirect illumination and sclerotic scatter illumination; and a camera generating images of the eye during both the first and second illumination patterns.

Abstract: An ophthalmic system of an embodiment includes a slit lamp microscope, three dimensional image constructing unit, rendering processor, display controller, report creating unit, and report output unit. The slit lamp microscope includes a front image acquiring unit that photographs an anterior eye segment to acquire a front image, and an image collecting unit that photographs the anterior eye segment with slit light to collect a plurality of images. The three dimensional image constructing unit constructs a three dimensional image based on the collected images. The rendering processor applies rendering to the three dimensional image to construct a rendered image. The display controller displays the front image and the rendered image on a display device. The report creating unit includes a user interface used for creating a report on information displayed. The report output unit outputs the report.

Abstract: A head-mounted device may include a processor configured to receive information from a sensor that is indicative of a position of the head-mounted device relative to a reference point on a face of a user; and adjust a rendering of an item of virtual content based on the position or a change in the position of the device relative to the face. The sensor may be distance sensor, and the processor may be configured to adjust the rendering of the item of virtual content based a measured distance or change of distance between the head-mounted device and the point of reference on the user's face. The point of reference on the user's face may be one or both of the user's eyes.

Abstract: A base for a slit lamp having a table and a frame mounted to the table, the base comprising a carriage configured to support a biomicroscope, a first elongate member extending horizontally through the carriage, and a second elongate member extending horizontally through the carriage. The carriage is slidable axially along the first elongate member and the second elongate member to move the biomicroscope relative to the frame. The second elongate member provides a stabilizing force on the carriage to counteract an upward force exerted by the carriage and the biomicroscope mounted thereon.

Abstract: An ophthalmic system of an embodiment includes a slit lamp microscope and an information processing apparatus. The slit lamp microscope includes an image acquisition device that acquires a three dimensional image by photographing a subject's eye, and a first communication device that transmits the three dimensional image to the information processing apparatus. The information processing apparatus includes a second communication device that receives the three dimensional image transmitted by the first communication device, a display controller that displays a first image based on the three dimensional image on a display device, a partial region designation processor that designates a partial region of the first image, and a rendering processor that renders the three dimensional image based on the partial region to construct a second image. The display controller displays the second image on the display device.

Abstract: The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. A?-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.

Abstract: Systems, apparatuses, and methods of and for an ophthalmic surgical system are disclosed. An ophthalmic surgical system may include a surgical microscope through which a user may view a surgical site. A display device in communication with the surgical microscope may output a graphical overlay into the field of view of the surgical microscope. The graphical overlay may display one or more configurable parameters associated with a surgical tool. A user may adjust the one or more configurable parameters with an input device while visualizing the field of view.

Abstract: To adapt a housing (2) to an uneven standing surface, an adjustment device (1) has a foot piece (3) with an internal thread (5) that defines a displacement axis (4). The foot piece is located in a recess (6) of the housing that is accessed from a surface of the housing that faces towards the standing surface. A cross-sectional profile of the foot piece perpendicular to the displacement axis coacts with the recess to prevent rotation of the foot piece about the displacement axis. A spindle (7) with an external thread (8) that cooperates with the internal thread of the foot piece allows axial movement of the spindle along the displacement axis. A levelling wheel (9), connected to the spindle by a rotation-blocking connection allows the spindle to be rotated relative to the foot piece.

Abstract: A stereoscopic picture taking systems includes a first camera having a first optical objective, and a second camera having a second optical objective, where the optical characteristics of the two objectives are substantially identical. The stereoscopic system also includes a plane semi-reflecting plate in front of the first objective and inclined by a predetermined angle on the optical axis of the first objective. The stereoscopic picture taking system also includes an optical element having a plane reflecting surface disposed at the level of the second objective and inclined by the same predetermined angle on the optical axis of the second objective such way that the main part of the optical axis of the second objective is substantially parallel to the optical axis of the first objective. This optical element can be a plane mirror or a return prism. The first objective has a plate of identical optical thickness.

Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.

Abstract: According to one embodiment, an ophthalmic microscope includes an illumination system, a pair of light-receiving systems, and a first mechanism. The illumination system is configured to irradiate a subject's eye with illumination light. Each of the light-receiving systems includes a first objective lens and a first imaging device, and is configured to guide return light of the illumination light returning from the subject's eye to the first imaging device through the first objective lens. The objective optical axes of the light-receiving systems are not parallel to each other. The first mechanism is configured to move the light-receiving systems relative to each other to change an angle formed by the objective optical axes of the light-receiving systems.

Abstract: A portable digital imaging device, which utilizes the advanced features of wireless data transmission and high computing power of mobile computing devices in junction with the use miniature cameras and solid state lighting technology, is proposed as the next generation of medical imaging devices, in particular in ophthalmic imaging applications.

Abstract: Provided is a slit lamp microscope capable of controlling irradiation of slit light and background illumination light interlockingly. Embodiment includes a main illumination system, background illumination system, observation system and controller. The main illumination system includes a first light source unit that outputs first light and slit forming unit that forms a slit with changeable width, and illuminates an eye with the first light having passed through the slit. The background illumination system includes a second light source unit that outputs second light, and illuminates a peripheral area of an eye area irradiated with the first light. The observation system includes an eyepiece lens, imaging device, and group of optical elements that guides reflected light of the first light and reflected light of the second light from the eye to the eyepiece lens and imaging device. The controller interlockingly controls the main illumination system and second light source unit.

Abstract: Systems and methods for measuring a patient's relative ocular distention as an indicator of eye, brain, and systemic hemodynamic and physiological conditions are provided. Ocular distention is measured and displayed continuously through the closed eyelid by strain imaging techniques, for example with ultrasound or optical computed tomography.

Abstract: A slit lamp mounted eye imaging, a slit lamp integrated, a handheld, OCT integrated, or attached to a separate chinrest-joystick assembly apparatus and method for producing a wide field and/or magnified views of the posterior or the anterior segments of an eye through an undilated or dilated pupil is disclosed. The apparatus images sections and focal planes and utilizes an illumination system that uses one or more LEDs, shifting optical elements, flipping masks, and/or aperture stops where the light can be delivered into the optical system on optical axis or off axis from center of optical system and return imaging path from the eye, creating artifacts in different locations on the eye image. Image processing is employed to detect and eliminate artifacts and masks from images. The apparatus can be used in combination with an OCT, microscope and can be disposed in a hand-held housing for hand-held use.

Abstract: The invention relates to a device for machining an object by laser radiation, in particular by using the photodisruption method. Said device comprises an observation device for imaging the object and a laser scanning device by which the laser radiation is passed over a predetermined sector of the object for scanning said sector. According to the invention, such a device includes the observation device with a first lens for imaging the object; the laser scanning device with a second lens, through which the laser radiation is guided, in which both lenses with regard to the dimension of the regions to be produced in the images and/or with regard to their focal intercept are different from each other. This invention alternately images the respective region of the object in a first operating mode by the first lens and in a second operating mode by the second lens. It is thus possible to use in both operating modes a lens adapted to the intended imaging purpose.

Abstract: A retinal imaging device and illumination module. The illumination module includes a light source to provide an incident beam along an illumination axis, a condenser lens at a spaced apart distance from the light source for condensing the incident beam and emanating a condensed incident beam, a transparent plate at a spaced apart distance from the condenser lens, wherein the transparent plate comprises a light absorber, at least one projections lens system to focus the condensed incident beam, a shield at a spaced apart distance from the projection lens system to yield a first partially blocked beam to form a comea illumination doughnut, and a perforated mirror comprising a hollow cylinder. A portion of the hollow cylinder protrudes out from a reflecting face of the mirror, forming an elliptical stopper to yield a second partially blocked beam to form a pupil illumination doughnut, enabling reflex-free imaging of the retina.

Abstract: An optical coherence eye-fundus tomography device has a high resolution and a good operability, as well as be miniaturized and be produced at a low cost. The optical coherence eye-fundus tomography device includes: a light source unit which emits a source light beam; a reference-light unit which reflects a reference light beam; an inspection unit which illuminates an object with an object scanning light beam, reflected the object scanning light beam; and a detection unit which obtains a tomographic image of the object on the basis of the interference light beam produced by interfering the reflected reference light beam with the reflected object light beam. For example, the light source unit emits the outgoing light beam that has a depth of focus of not less than 300 ?m, and resolution that is 6 ?m×6 ?m or higher in a planar direction perpendicular to a traveling direction of the outgoing light beam.

Abstract: Example embodiments of a large dynamic range sequential wavefront sensor for vision correction or assessment procedures are disclosed. An example embodiment includes first and second optically coupled 4F relays and a variable focus lens disposed substantially at the image plane of the first 4F relay and the object plane of the second 4F relay.

Abstract: An optical system (120) for detecting optical aberrations of light from an object (101), the optical system comprising: a reference light-source (102) providing collimated reference light; an optical element (212) configured to focus at least one collimated light beam incident on the optical element (212) to a plurality of focal points in a conjugate object plane (214), the optical element (212) being arranged in an optical path between the reference light-source (102) and the object (101) for transmitting a plurality of reference light beams towards the object (101); and a wavefront sensor (112) configured to detect a property indicative of an optical aberration of light incident on the wavefront sensor; wherein the optical element (212) is further arranged to transmit a plurality of reflected guide star light beams resulting from reflection of the reference light beams at the object (101) towards the wavefront sensor (112).

Abstract: Methods and apparatus for automatically aligning a confocal aperture utilize a confocal imaging system and a computer controlled optimization algorithm such as the Nelder-Mead algorithm for imaging an in-vivo eye having chromatic aberration. When using a confocal aperture of 3.4 Airy disks in diameter, images were obtained using retinal radiant exposures of less than 2.44 J/cm2, which is ˜22 times below the current ANSI maximum permissible exposure. The embodied method can be used, e.g., to study RPE morphology in AMD and other diseases, providing a powerful tool for understanding disease pathogenesis and progression, and offering a new means to assess the efficacy of treatments designed to restore RPE health.

Abstract: The present invention relates to an illumination device for a stereomicroscope, in particular a surgical microscope for eye surgery, having at least one light source (10), a collector lens system (14), an aperture diaphragm (16), a condenser lens system (18), and an objective (22), illumination light being directed from the light source (10) through the collector lens system (14), the aperture diaphragm (16), the condenser lens system (18), and the objective (22) into the object plane (E19), the aperture diaphragm (16) being provided as a double orifice plate or four-orifice plate.

Abstract: An wavefront sensor uses a calibration wave generator to calculate correction factors to be applied to ratiometric combinations of position sensor output signals to determine real centroid deflection values.

Abstract: A sequential wavefront sensor includes a light source, a beam deflecting element, a position sensing detector configured to output a plurality of output signals and a plurality of composite transimpedance amplifiers each coupled to receive an output signal. The output of each composite transimpedance amplifier is phase-locked to a light source drive signal and a beam deflecting element drive signal.

Abstract: Combined equipment for non-contacting determination of axial length (AL), anterior chamber depth (VKT) and corneal curvature (HHK) of the eye, are also important for the selection of the intraocular lens IOL to be implanted, particularly the selection of an intraocular lens (IOL) to be implanted, preferably with fixation of the eye by means of a fixating lamp and/or illumination through light sources grouped eccentrically about the observation axis.

Abstract: The present invention relates to a wavefront sensor using a pair of screens, each having a two-dimensional array of circular apertures, to achieve Moiré effects, and its use to measure the slope of a wavefront.

Abstract: Among other things, an illumination device (10) is described for one, two or more observation beam paths, each with an observation device having an observation beam bundle, in particular for an operating microscope, having at least one light source (12) for producing at least one illumination beam bundle for illuminating an object to be observed (13), in particular, an eye to be observed, wherein the at least one illumination beam bundle runs coaxially to an observation beam bundle. It is provided according to the invention, in order to be able to suppress disruptive reflections, that illumination device (10) has an illumination optics (11) that is constructed according to the Köhler principle of illumination, and in which at least one reflection diaphragm (18) is provided in order to avoid light reflected from the surface of an objective element (19). In addition, a correspondingly improved observation device is described.

Abstract: The present patent application discloses a digital slit-lamp microscope system and the methods of the electronic recording and remote diagnosis. The present patent application relates to the field of optical instrument and remote communication control. The purpose is to solve the problems of the electronic recording, reappearing and remote diagnosis of the slit-lamp image. The digital slit-lamp microscope system comprises digital slit-lamp microscope side, communication unit and client side. The digital slit-lamp microscope side includes a build-in slit-lamp microscope and is connected to the communication unit and the client side in sequence. The digital slit-lamp microscope side irradiates the eyes of the patient, and then transmits the pathology information of the eyes of the patient to the communication unit and the client side in sequence.

Abstract: In one embodiment, a wavefront sensor is combined with a slit lamp eye examination device so that real time aberration values of an eye being examined can be viewed during a slit lamp eye examination session.

Abstract: The slit lamp microscope is capable of easily adjusting a slit-light and a backlight. The slit lamp microscope comprises: a slit lamp for emitting a slit-light; a mirror unit having a reflecting mirror or a prism, which reflects the slit-light emitted from the slit lamp toward an eye of an examinee; a microscope unit for observing the eye of the examinee; and a backlight source for emitting a backlight, which illuminates a circumference of the slit-light, toward the eye of the examinee. The backlight source is provided to the mirror unit.

Abstract: A fundus camera includes an illumination optical system, an observation photographic optical system, a photographic diaphragm unit located in a position conjugate with the subject's eye in the observation photographic optical system, and an imaging unit disposed in the observation photographic optical system. The photographic diaphragm unit includes a first photographic diaphragm fixed during capturing of a still image and a second photographic diaphragm movable during capturing of a moving image. The fundus camera further includes a diaphragm driving unit configured to move the second photographic diaphragm on a plane orthogonal to an optical axis, an image recording unit configured to capture, with the first photographic diaphragm, a still image based on an output of the imaging unit and, with the second photographic diaphragm, a moving image based on an output of the imaging unit, and a display unit configured to display an image captured by the imaging unit.

Abstract: An opthalmological measuring instrument, e.g. for determining the corneal curvature, anterior chamber depth, axial length, or the like, including measuring systems for determining measurement of the mentioned physical parameters. The measuring systems are connected to an evaluation unit which verifies whether quality parameters regarding the measurements are satisfied and generates a corresponding signal that indicates to the medical professional user that a proper measurement can be taken.

Abstract: For processing eye tissue (8) by means of femtosecond laser pulses, an ophthalmological device (1) includes a projection optical unit (2) for the focused projection of the femtosecond laser pulses into the eye tissue (8). Disposed upstream of the projection optical unit (2) is a first beam-deflecting scanner system (3) for scanning the eye tissue (8) with the femtosecond laser pulses along a processing line. A second beam-deflecting scanner system (5) is disposed upstream of the first scanner system (3) and is designed for scanning the eye tissue (8) with the femtosecond laser pulses in a scanning movement superimposed on the processing line and running in a deflection plane. The second scanner system (5) has a scanner speed that is a multiple of the scanning speed of the first scanner system (3). A rotation system is provided for aligning the deflection plane with a defined angle with respect to the processing line.

Abstract: A slit lamp microscope capable of appropriately and easily carrying out the setting of the optical system is provided. In storage 102 of a slit lamp microscope 1, correspondence information 110 is stored in which standard setting conditions of an illumination system 8 and/or an observation system 6 are associated with each of multiple sites of an eye E. A searching part 121 searches the standard setting conditions corresponding to a site designated by an operation part 104 from the correspondence information 110. A setting-state acquiring part 122 acquires current setting states of the illumination system 8 and/or the observation system 6. A setting-state specifying part specifies, from among the current setting states acquired by the setting-state acquiring part 122, those differing from the standard setting conditions searched by the searching part 121. A controller displays information based on this specified result on the display 103.

Abstract: Example embodiments of a large dynamic range sequential wavefront sensor for vision correction or assessment procedures are disclosed. An example embodiment optically relays a wavefront from an eye pupil or corneal plane to a wavefront sampling plane in such a manner that somewhere in the relaying process, the wavefront beam from the eye within a large eye diopter range is made to reside within a desired physical dimension over a certain axial distance range in a wavefront image space and/or a Fourier transform space. As a result, a wavefront beam shifting device can be disposed there to fully intercept and hence shift the whole beam to transversely shift the relayed wavefront.

Abstract: The present invention relates to a slit lamp unit (1) for a surgical microscope, the slit lamp unit (1) comprising a slit illumination unit (2) having a slit illumination optic for generating a slit illumination beam path (5, 6), and a guide rail (3) for displacement of the slit illumination unit (2) along a direction designated by the guide rail (3), the guide rail being embodied for displacement of the slit illumination unit (2) along a linear direction (12), and the slit illumination unit (2) being mounted on the guide rail (3) rotatably around a rotation axis (13) perpendicular to said linear displacement direction (12).

Abstract: A retinoscope for detecting eye ametropia and astigmatism axes is disclosed in the invention, which comprises an illuminating and imaging system comprising an illumination light source, a projecting mirror and a half transparent and half reflecting mirror arranged sequentially along the direction of propagation of the illumination light, the respective optical axes of the projecting mirror and half transparent and half reflecting mirror are collinear with each other, and the reflecting plane of the half transparent and half reflecting mirror is at an angle of 45° relative to the illumination optical axis, wherein a condensing lens column and a retinoscopy diaphragm are disposed sequentially along the illumination optical axis between the illumination light source and the projecting mirror, the optical axis of the condensing lens column is coincident with the illumination optical axis, and the plane of the retinoscopy diaphragm is perpendicular to the illumination optical axis.

Abstract: A wavefront sensor includes a light source configured to illuminate a subject eye, a detector, a first beam deflecting element configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source and configured to direct a portion of the wavefront from the subject eye through an aperture toward the detector and a controller, coupled to the light source and the beam deflecting element, configured to control the beam deflecting element to deflect and project different portions of an annular ring portion of the wavefront from the subject eye through the aperture and further configured to pulse the light source at a firing rate to sample selected portions of the annular ring at the detector.

Abstract: An apparatus including a position sensing detector and a processing system, with the processing system configured to determine axis of astigmatism and cylinder and sphere diopter values of a subject eye.

Abstract: A sequential wavefront sensor includes a light source, a beam deflecting element, a position sensing detector configured to output a plurality of output signals and a plurality of composite transimpedance amplifiers each coupled to receive an output signal. The output of each composite transimpedance amplifier is phase-locked to a light source drive signal and a beam deflecting element drive signal.

Abstract: An ophthalmologic apparatus includes an aberration measurement unit configured to measure aberration caused by a subject's eye by using a return beam of a first measuring beam from the subject's eye, a correction unit configured to correct aberration of a return beam of a second measuring beam from the subject's eye caused by the subject's eye based on the aberration measured by the aberration measurement unit, a first acquisition unit configured to obtain a first image of the subject's eye by using the aberration-corrected return beam of the second measuring beam from the subject's eye, and a control unit configured to enter one of the first measuring beam and the second measuring beam into the subject's eye while limiting entry of the other measuring beams into the subject's eye.

Abstract: A tonometer for measuring intraocular pressure of an examinee's eye in a non-contact manner, comprises: an arithmetic part for calculating the intraocular pressure; a fluid blowing unit for blowing a fluid at a cornea of the examinee's eye through a nozzle; a projecting optical system for projecting light onto an anterior segment of the examinee's eye through the nozzle, the system including a light source and a condensing lens; and an imaging optical system for imaging a cross-sectional image of the anterior segment, the system including an imaging lens and an imaging elements.

Abstract: A patient examination assembly comprises a rotatable stand adapted to mount a slit lamp microscope, and a phoropter attached to the stand by a telescoping arm assembly, comprising an arm and a connector and the connector comprises a first link and a second link. The first link is telescopeable within the second link.

Abstract: A patient examination assembly comprises a rotatable stand adapted to mount a slit lamp microscope, and a phoropter attached to the stand by a telescoping arm assembly, comprising an arm and a connector, and the connector comprises a first link and a second link. The first link is telescopeable within the second link.

Abstract: A simulator to be used in ophthalmological measurements includes a display apparatus and a control device. The control device is adapted to control the display apparatus in such a manner that the display apparatus displays an image that is adapted to simulate the arrangement of a pupillary midpoint relative to a reference structure.

Abstract: The present invention relates to an instrument for eye (E) examination, the system including an imaging system (2) to produce images of a portion of the eye to be examined; a projection system (3) to project a stimulus of visible light on a location in the portion of the eye to be examined and a background light on the portion of the eye to be examined; in which the projection system (3) has a telecentric design to uniformly project the stimulus and the background and includes a light source (114) and a movable mirror (112) which is moved according to the location of stimulus projection.

Abstract: Positioning control relating to a two-aperture stop necessary for stereoscopic photography can be performed accurately and securely using a simple, inexpensive, compact, and lightweight structure. The apparatus comprises a two-aperture stop (28) provided with two stop apertures (28a, 28b), and a shutter plate (302) for opening and closing one of the two stop apertures. The two-aperture stop (28) is moved so as to intersect with an optical axis so that in monocular photography the two-aperture stop is positioned in a first position in which the stop aperture (28b) is disposed substantially at the center of the optical axis and so that in stereoscopic photography it is positioned in a second position in which the two stop apertures (28a, 28b) are disposed off-center from the optical axis.

Abstract: An ophthalmic device and an arrangement for generating images with expanded dynamic range and a corresponding method for generating images with expanded dynamic range have at least one beamsplitter, in particular with an asymmetric splitting ratio, and at least two image sensors, wherein the image sensors are reflected into a common imaging beam path by the at least one beamsplitter.

Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye, in non-contact manner by use of an ultrasonic wave comprises: a probe including a vibrator for making the ultrasonic wave incident on the examinee's eye and a sensor for detecting the ultrasonic wave reflected from the examinee's eye; and an observation optical system for observing an anterior segment of the eye, wherein the probe is placed in an optical path of the observation optical system, and the observation optical system forms an image of the anterior segment through a surrounding region of the probe.