Abstract: A method of fusing 2D and 3D imaging data includes receiving 3D imaging data and 2D color imaging data of a region of interest, segmenting the 3D imaging data to identify anatomical features in the region of interest, including surfaces of the anatomical features and a corresponding volume of the anatomical features, and generating an image by fusing the 2D color imaging data to the 3D imaging data according to the surfaces, the corresponding volumes, and identities of the anatomical features. In some cases, the 3D imaging data is captured via optical coherence tomography. In some cases, the 2D color imaging data is captured via color microscopy. In some cases, the method further includes rendering a final image at an output plane by casting a ray through the fused 3D imaging data for each pixel and viewpoint of the output image plane for the image.

Abstract: A color checker device is disclosed. The color checker device includes a substrate configured to be inserted into a model eye and to conform to a surface curvature of the model eye when inserted therein. A color test target is located on the substrate. The color test target comprises a plurality of color sections configured for generating a color characterization profile of a fundus imaging camera configured to capture a color image of a human retina. A method of generating a color characterization profile using the color checker device and a fundus imaging system having the color characterization profile stored thereon are also disclosed.

Abstract: An optical system for a virtual retinal scan display. The optical system includes an image source which supplies image data, an image processing device for the image data, a projector unit having a light source modulatable in time for generating a light beam, and an actuable refraction device for the light beam for the scanning projection of the image content, a deflection unit onto which the image content is able to be projected and which is designed to guide the projected image content onto an eye of a user, and an adaptive optical element for modifying a beam divergence, which is situated in the optical path between the light source and the deflection unit. The adaptive optical element is able to be actuated so that the beam divergence of the light beam is variable as a function of the angle of incidence of the light beam on the deflection unit.

Abstract: A head-mounted display device and a control method for an eye-tracking operation are provided. The head-mounted display device includes a frame, a track, a sensor and a controller. The track is disposed on a peripheral region of the frame. The sensor is disposed on the track, and is configured to capture a target image of a target area. The controller is coupled to the sensor, is configured to generate a control signal according to the target image, and adjust a position of the sensor on the peripheral region by moving the sensor according to the control signal.

Abstract: An ophthalmic illumination method and system with a head-up display imaging system is provided wherein a therapeutic light is generated by a first laser light source configured to generate therapeutic light and a near-infrared wavelength of an alignment pattern is generated by a second laser light source, where the therapeutic light is directed upon an eye to be examined or treated in accordance with the alignment pattern.

Abstract: Systems and methods for imaging a target feature of a subject based on the tracked positions of the subject and the target feature are disclosed. According to an aspect, a system includes a scanner configured to image a target feature of a subject. The system includes a mechanism configured to move the scanner. Further, the system includes a subject tracker configured to track positioning of the subject. The system includes a feature tracker configured to track positioning of the target feature. A controller is configured to control the mechanism to move the feature tracker to a position such that the feature tracker is operable to track a position of the target feature. The controller controls the mechanism to move the scanner to a position such that the scanner is operable to image the target feature based on the tracked position of the target feature by the feature tracker.

Abstract: Provided are apparatus and method for predicting biometrics using a fundus image. The method for predicting biometrics using a fundus image includes steps of preparation of a plurality of learning fundus images, generation of a learning model for predicting corresponding biometrics using the prepared data based on at least one characteristic of the fundus reflected in the prepared plurality of learning fundus images, reception of a prediction target of fundus image, and prediction of the biometrics of the subject of the prediction target of fundus image by using the generated learning model.

Abstract: Disclosed herein are systems, methods, devices, and media for carrying out detection of ophthalmic and systemic diseases and disorders. Deep learning algorithms enable the automated analysis of ophthalmic images such as retinal scans to generate accurate detection of various diseases and disorders. Point-of-care implementations allow for rapid and efficient detection outside of the clinical setting.

Abstract: The present application discloses a focal length adjustment method, device, apparatus and computer readable storage medium for AR glasses, the method includes: receiving a focal length adjustment command, and displaying a preset circle with a preset reference radius through a display module; capturing a first image of the preset circle in an eye of a wearer of the AR glasses through the camera to obtain a first captured image, and determining a first imaging radius of the preset circle in the first image according to the first captured image; determining target diopter of the eye of the wearer according to the preset reference radius and the first imaging radius; and determining a target deflecting angle of the display module according to the target diopter, and adjusting the display module according to the target deflecting angle.

Abstract: This invention relates to optical methods and optical systems for making both on-axis and wide-field, peripheral off-axis wavefront measurements of an eye; and for designing and manufacturing wavefront-guided customized contact lens useful for myopia control. The wide-field optical instrument can comprise either (1) a multi-axis optical configuration using multiple off-axis beamlets, or (2) an instrument comprising a rotatable scanning mirror that generates off-axis probe beams.

Abstract: A subjective and objective integrated precise optometry device, and an optometry method are provided. The device has a left eye optical path and a right eye optical path. Each of the single eye optical paths comprises a human eye refraction objective measurement subsystem, a human eye refraction correction subsystem, an eyeball positioning subsystem, and a subjective visual function testing subsystem. The device has functions such as objective measurement for monocular and binocular refraction, continuous subjective optometry, interpupillary distance measurement, and monocular and binocular visual function measurement (comprising, but not limited to, vision and stereopsis), and can implement subjective and objective integrated precise monocular and binocular optometry.

Abstract: Methods for assessing a skin surface of a patient and associated systems and devices are described herein. A method configured in accordance with embodiments of the present technology can include, for example, receiving a three-dimensional data set representative of the patient's skin surface and determining a boundary of a feature of the patient's skin in the three-dimensional data set. The method can further include determining, with a processor, a three-dimensional surface area of the feature within the boundary. In some embodiments, the method can also include identifying a plurality of sub-regions within the boundary and identifying one or more tissue types in each sub-region.

Abstract: An ophthalmic apparatus includes an irradiation optical system, an optical scanner, an optical splitting and combining unit, and a detector. The irradiation optical system includes a light source and is configured to generate measurement light using light from the light source. The optical scanner is configured to deflect the measurement light and to guide the deflected measurement light to a subject's eye. The optical splitting and combining unit is configured to guide the measurement light to the optical scanner and to generate interference light between reference light that is generated from the light from the light source and returning light of the measurement light from the subject's eye. The detector is configured to detect the returning light and the interference light via the optical splitting and combining unit.

Abstract: The ophthalmologic microscope comprises a first component including a base and a stage, a second component including a pivotal arm and a microscope device, and a third component including a pivotal arm and a light source. The various components are mutually pivotal at a hinge. An electronically controlled brake and a position sensor are incorporated into the hinge. The brake controller of the microscope is adapted to interrupt a manual mutual displacement of the components in response to a signal from the position sensor in order to assist the user in properly aligning the components.

Abstract: An ophthalmic lens (1), a film for use in an ophthalmic lens (1) and a method (500) of manufacturing an ophthalmic lens (1) are described. The lens (1) has an optical axis. The lens (1) comprises a layer (3) provided on a surface of a substrate (5). The layer (3) has a base refractive index and includes at least one gradient index optical element (7a, 7b) having an asymmetric refractive index profile. The at least one gradient index optical element (7a, 7b) focuses light from a distant point source on the optical axis to a point that is a first distance from the optical axis (2).

Abstract: A personal authentication apparatus comprises an acquisition unit configured to acquire an eyeball image of a user, an estimation unit configured to estimate, based on a ghost captured in the eyeball image, information on eyeglasses worn by the user, and an authentication unit configured to perform personal authentication on the user based on the eyeball image and the information on the eyeglasses.

Abstract: A computer-implemented method, system, and computer-readable medium, for determining a level of hypertension of a person. Image data defining a retinal image of a retina of the person that has been captured by a retinal imaging system is acquired. Processing the image data is performed to identify a plurality of vessel segments present in the retinal image. Determining is performed of respective widths of vessel segments of at least a subset of the plurality of vessel segments present in the retinal image. Calculating, as a vascular summary metric, at least one average value or median value of the determined widths of the vessel segments present in the retinal image, is performed to determine a level of hypertension by which the person has been affected.

Abstract: An ophthalmic laser system uses a non-confocal configuration to determine a laser beam focus position relative to the patient interface (PI) surface. The system includes a light intensity detector with no confocal lens or pinhole between the detector and the objective lens. When the objective focuses the light to a target focus point inside the PI lens at a particular offset from its distal surface, the light signal at the detector peaks. The offset value is determined by fixed system parameters, and can also be empirically determined by directly measuring the PI lens surface by observing the effect of plasma formation at the glass surface. During ophthalmic procedures, the laser focus is first scanned insider the PI lens, and the target focus point location is determined from the peak of the detector signal. The known offset value is then added to obtain the location of the PI lens surface.

Abstract: A device includes a contact lens, a corneal sensor that includes a circular trace of conduction paths located at or near an outer peripheral edge of the contact lens that surrounds an unobstructed area at a center region of the contact lens, and a connection wire coupled to the corneal sensor and configured to electrically couple to an external data acquisition system. Methods of fabricating the device may include providing a thin device that includes a sensor and a connection wire coupled to the sensor, transferring the sensor to a curvilinear inner surface of a contact lens, feeding the connection wire through the inner surface of the contact lens and out of an outer surface of the contact lens, and performing electrochemical polymerization of a conducting polymer material over the sensor to anchor the sensor to the inner surface of the contact lens.

Abstract: In certain embodiments, a system for calibrating the focal point of a laser beam comprises a laser, focusing optics, detector optics, a two-photon absorption (TPA) detector, and a computer. The laser generates the laser beam. The focusing optics direct the focal point of the laser beam along a z-axis towards a zero-surface corresponding to a zero-plane, and receives a portion of the laser beam reflected by the zero-surface. The detector optics receive the reflected portion from the focusing optics, and directs the reflected portion towards a TPA detector. The TPA detector senses the peak intensity of the reflected portion, which indicates a proximity of the focal point to the zero-surface, and generates a signal representing the peak intensity of the reflected portion. The computer determines whether the focal point of the laser beam is calibrated in response to the signal representing the peak intensity.

Abstract: An ophthalmic device including a scanning optical system configured to scan an examined eye with light from a light source, a fixation light source configured to illuminate fixation light onto the examined eye through the scanning optical system so as to function as a fixation target, and a fixation light scanning section configured to scan the fixation light synchronized to scanning of the scanning optical system such that an illuminated fixation target does not move a specific distance or greater due to scanning of the scanning optical system.

Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source, such as a pupilometer and determining whether one of various pupillary response conditions is met.

Abstract: A system for visualization of eye anatomy includes at least one camera having a view vector along a first axis when in a first position, a housing to which the camera is coupled, wherein the housing engages the head of a patient such that the camera is positioned adjacent a patient's eye, and an actuator that moves the camera from the first position to a second position with a view vector along a second axis that is offset from the first axis. A method of visualization of eye anatomy includes engaging a patient's head with a housing, positioning at least one camera coupled to the housing adjacent an eye, wherein the camera has a view vector along a first axis when in a first position, and moving the camera to a second position with a view vector along a second axis offset from the first axis.

Abstract: An ophthalmic imaging device (300) includes a fundus module (210) and a slit lamp 5 module (220) movably coupled to each other. The fundus module (210) includes an illumination module (230) and an imaging module (240). The illumination module (230) is adapted to yield a first partially blocked beam. The imaging module (240) includes a mirror (324) with a hole and an objective lens (326) to produce a reflected first partially blocked beam and a second partially blocked beam, to form a cornea 10 illuminating doughnut (502) and pupil illuminating doughnut (504), respectively, on an anterior region of the eye and form an image of the posterior\\region of the eye on an image plane (346). The slit lamp module (220) is adapted to view and capture the image of anterior and posterior regions of the eye.

Abstract: A retinal imaging system includes a projector, an imaging device, and a controller coupled to an eye tracking system under test. The projector emits a light pattern to be delivered to a pupil of an eye, a location of the pupil being estimated by the eye tracking system under test. The imaging device captures one or more images of a retina of the eye illuminated with at least a portion of the light pattern. The controller determines one or more eye tracking parameters based on the captured one or more images of the retina. The controller compares each determined eye tracking parameter with each of estimated one or more eye tracking parameters, wherein values for the one or more eye tracking parameters are estimated by the eye tracking system under test. The controller characterizes each estimated eye tracking parameter based on the comparison.

Abstract: Systems and methods are disclosed herein for adjusting flash intensity based on retinal pigmentation. In an embodiment, a processor determines a retinal pigmentation of a retina of an eye positioned at an imaging device. The processor commands the imaging device to adjust an intensity of a flash component from a first intensity to a second intensity based on the retinal pigmentation. The processor commands the imaging device to capture an image that is lit by the flash component at the second intensity, and receives the image from the imaging device.

Abstract: A non-mydriatic, non-contact ultra-widefield fundus (u-WF) photographic imaging system and method are provided for performing u-WF photographic imaging of the eye. The non-mydriatic, non-contact u-WF photographic imaging system includes an illumination system that delivers trans-pars-planar illumination to the eyeball. This frees the entire pupil to be used for imaging. Freeing the entire pupil to be used for imaging allows a u-WFC of the non-mydriatic, non-contact u-WF photographic imaging system to use a relatively simple optics system to capture an ultra-wide FOV. Eliminating the need to dilate the pupil and the need to make contact with the eye while performing imaging eliminates the many problems associated with mydriatic, contact-mode fundus imaging systems and methods. In addition, the system can be implemented in a way that makes it highly suitable for telemedicine applications in underserved areas where clinics and trained healthcare providers may not be available.

Abstract: A method for examining a driver of a vehicle. In accordance with the method, at least one part of at least one eye and/or at least one part of the face of the driver is captured using a monitoring unit. The data captured by the monitoring unit is evaluated and the visual perception capability of the driver is examined based on the captured data. The method may further include identifying the driver and operating devices of the vehicle using the captured data.

Abstract: A system for identifying structures in an eye of a subject. In embodiments of the invention, the system has a housing; a visible light source supported by the housing; an infrared light source supported by the housing; a photodetector supported by the housing; a patient interface disposed on an outer surface of the housing arranged and configured so that, when the patient interface is placed in contact with the subject, the subject's eye is aligned with the light sources and the photodetector such that the light sources illuminate an iris of the eye at an angle between 15° and 30° and such that the photodetector receives light from the light sources reflected by the iris; and a controller configured to activate the visible light source and the infrared light source and to obtain image information from the photodetector.

Abstract: A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.

Abstract: A system includes: at least one processor; a movable stage, wherein the movable stage is movable under control of the at least one processor with respect to an eye of a subject; a video display device configured to move with the movable stage; and an optical system disposed in an optical path between the video display device and the eye. The video display device is configured to play a movie of a fixation target to the eye to cause the eye to accommodate, and the movie dynamically changes an appearance of the fixation target on the video display device to compensate for Bokeh of the fixation target as the movable stage moves the video display device from a first position, where the fixation target draws a focus of the eye to near its far point, to a second position further away from the eye than the first position.

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

Abstract: A system includes: a first movable stage which is movable with respect to an eye of a subject; a second movable stage mounted on the first movable stage, wherein the second movable stage is movable with respect to the first movable stage; a fixation target disposed on the second movable stage; and an optical system disposed in an optical path between the fixation target and the eye, wherein the optical system is configured for projecting the fixation target upon the eye to accommodate the eye, and wherein moving the second movable stage to a position where the fixation target is moved away from the eye by an additional amount causes blur cues of the fixation target to indicate to the subject that the fixation target is moving away from the eye while the size of an image of the fixation target on the retina of the eye decreases.

Abstract: The present invention generally relates to an image-guided laser irradiation device for targeted ablation, stimulation, molecular delivery and therapy. Specifically, the invention relates to application of the device in therapies needing precise and targeted removal of a sample, or delivery of impermeable molecules for therapeutic outcome. More specifically, the invention relates to the application of the device in the therapy of visual disorders.

Abstract: An image acquisition unit (2) acquires an image obtained by capturing at least eyes of a target person. An object specifying unit (4) specifies an object in a line-of-sight direction of the target person using the acquired image. An incident light amount calculation unit (6) calculates an incident light amount representing an amount of light incident on the eyes of the target person using the acquired image. A reference pupil size determination unit (8) determines a reference pupil size based on the calculated incident light amount. A pupil size calculation unit (10) calculates a pupil size of the target person using the acquired image. An interest determination unit (12) determines an interest of the target person in the object by comparing the determined reference pupil size with the calculated pupil size.

Abstract: An eye measurement system includes an optical system. The eye measurement system is disposed in a housing which includes an aperture for providing light to and from the optical system and a subject's eye while the subject is separated and spaced apart from the housing, and the eye is not maintained in a fixed positional relationship with respect to the housing. An optical system movement arrangement moves the optical system. An automatic eye tracking arrangement ascertains a current positional relationship of the eye with respect to the optical system without human assistance, and in response thereto controls the optical system movement arrangement to move the optical system into a predetermined positional relationship with respect to the eye, for measurement of the eye, without human assistance. The eye measurement system can make objective, and/or subjective, refraction measurements of the eye.

Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: An example device is configured to capture an image of an eye. The device includes a camera configured to capture the image of the eye. The device also includes: a first base configured to be moved along a first axis to position the camera to capture the image of the eye; a second base configured to be moved along a second axis to position the camera to capture the image of the eye; and a third base configured to be moved along a third axis to position the camera to capture the image of the eye.

Abstract: Disclosed is a method of measuring a refractive error using a reflection image of a pupil for a visible ray, the method capable of diagnosing and self-examining a refractive error using only an image captured by a smartphone camera. The method may include obtaining an image by projecting a visible ray, using a flash, onto the retina of a subject and capturing, using a smartphone camera, a shape and location of the image reflected in the pupil of the subject, applying the image to a residual neural network (ResNet) model trained using data of an ImageNet based on clinical information into which result values of a refractive error of the subjects have been incorporated, and outputting the refractive error of the image and a measurement factor measured to determine the refractive error based on the shape and the location reflected in the pupil in a process of deriving the refractive error of the image.

Abstract: A handheld ophthalmic device configured to perform various optical diagnostic tests to determine the health of a subject's eye. The handheld ophthalmic device is configured to be attached to a smartphone, a cell phone or an electronic tablet. The smartphone, a cell phone or an electronic tablet can be used to view images obtained by the handheld ophthalmic device and to transmit data and images obtained by the handheld ophthalmic device to an ophthalmologist located remotely.

Abstract: A method for testing the eyes of a test person with the aid of a vision testing system as well as to a vision testing system, comprising a first measuring device, a second topographic measuring device, a third refractive measuring device and a processing means, a central axial length (LZ) and a peripheral axial length (LP) of an eye of the test person being measured with the aid of said first measuring device, a curvature of the cornea of the eye being measured with the aid of said second measuring device, a refractive property of the eye being measured with the aid of said third measuring device, measurement data of the measurements of the first, second and third measuring device being processed with the aid of said processing means, said processing means outputting the measurement data.

Abstract: An optical imaging system includes a first lens system housed in a body of a mobile telecommunication device, the first lens system having a first optical axis, a first entrance pupil fixed in space in a reference plane associated with said body, and a first focal length; and an optical telescope providing a diffraction-limited imaging within a spectral range from at least 486 nm to at least 656 nm. The optical imaging system is configured to image, when the optical telescope is inserted between the first lens system and an entrance pupil of a visual system of an eye (EPE), the EPE onto the first entrance pupil and vice versa with a substantially unit magnification.

Abstract: The present specification relates to Master-Slave (MS) interferometry for sensing the axial position of an object subject to optical coherence tomography (OCT) imaging, and to MS-OCT applied to curved and axially moving objects. The methods and apparatuses allow producing OCT signals from selected depths within the object irrespective of its axial position in respect to the imaging system. Images are obtained for curved objects that are flattened along a layer of interest in the object, images that are used to provide OCT angiography images less disturbed by axial movement or lateral scanning.

Abstract: The multi-scale scanning imaging system (200) of the retina comprises according to an example a lighting and detection module (210) configured for emitting a lighting beam and for detecting a beam reemitted by the retina, a first scanning module (231) of the lighting beam and the reemitted beam, a first optical path, referred to as a “wide field” path, and a second optical path, referred to as a “small field” path, for focusing the lighting beam on the retina and for receiving the beam reemitted by the retina. The “wide field” path comprises a first optical system (205, 201) configured to conjugate a plane located near a plane of rotation of the scanning module and the plane (17) of the entrance pupil of the eye (10).

Abstract: An optical imaging system includes a first lens system housed in a body of a mobile telecommunication device, the first lens system having a first optical axis, a first entrance pupil fixed in space in a reference plane associated with said body, and a first focal length; and an optical telescope providing a diffraction-limited imaging within a spectral range from at least 486 nm to at least 656 nm. The optical imaging system is configured to image, when the optical telescope is inserted between the first lens system and an entrance pupil of a visual system of an eye (EPE), the EPE onto the first entrance pupil and vice versa with a substantially unit magnification.

Abstract: An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

Abstract: A beam expander includes first and second optical elements spaced apart from each other, and a light diffuser having an angular aperture that diffuses incident light through the angular aperture, wherein the first optical element in-couples the diffused light such that light exiting the first optical element has a first cross-sectional shape and light having a second cross-sectional shape different from the first cross-sectional shape is incident on the second optical element, and the second optical element out-couples light incident from the first optical element.

Abstract: A visual performance examination device includes a display control unit that displays an indicator at each of a plurality of positions in a display screen of a display device; an image data obtaining unit that obtains an image data of eyes of a test subject, which are irradiated with a detection light emitted from a light source; a position calculating unit that, based on the image data, calculates a position data of corneal reflexes of the eyes when each of a plurality of indicators displayed at the positions in the display screen is shown; and an evaluating unit that, based on relative positions of the indicators and relative positions of the corneal reflexes, outputs evaluation data about visual performance of the test subject.

Abstract: A retinal imaging system includes an image sensor for acquiring a retinal image and an illuminator for illuminating a retina to acquire the retinal image. The illuminator surrounds an aperture through which an image path for the retinal image passes before reaching the image sensor. Illumination sources surround the aperture.

Abstract: A method of detecting injury to the brain such as stroke, concussion and cognitive dysfunction using a contrast agent and light source. The blood ocular barrier is disrupted when said injury occurs, allowing the entry of contrast agent into the aqueous and vitreous humor. An exemplary method comprises injecting a contrast agent into a peripheral location and then testing for leakage of contrast agent into the eye cavity by observing for light reflection, when a beam of light incidents on the contrast agent in the eye.