Abstract: In certain embodiments, a system for calibrating the focal point of a laser beam comprises a laser, focusing optics, detector optics, a two-photon absorption (TPA) detector, and a computer. The laser generates the laser beam. The focusing optics direct the focal point of the laser beam along a z-axis towards a zero-surface corresponding to a zero-plane, and receives a portion of the laser beam reflected by the zero-surface. The detector optics receive the reflected portion from the focusing optics, and directs the reflected portion towards a TPA detector. The TPA detector senses the peak intensity of the reflected portion, which indicates a proximity of the focal point to the zero-surface, and generates a signal representing the peak intensity of the reflected portion. The computer determines whether the focal point of the laser beam is calibrated in response to the signal representing the peak intensity.

Abstract: An ophthalmic device including a scanning optical system configured to scan an examined eye with light from a light source, a fixation light source configured to illuminate fixation light onto the examined eye through the scanning optical system so as to function as a fixation target, and a fixation light scanning section configured to scan the fixation light synchronized to scanning of the scanning optical system such that an illuminated fixation target does not move a specific distance or greater due to scanning of the scanning optical system.

Abstract: A method of screening a pupil of a subject to determine whether the pupil reflex resembles a canonical pupil reflex is disclosed. The method comprises the steps of stimulating the pupil with a stimulus source, such as a pupilometer and determining whether one of various pupillary response conditions is met.

Abstract: A system for visualization of eye anatomy includes at least one camera having a view vector along a first axis when in a first position, a housing to which the camera is coupled, wherein the housing engages the head of a patient such that the camera is positioned adjacent a patient's eye, and an actuator that moves the camera from the first position to a second position with a view vector along a second axis that is offset from the first axis. A method of visualization of eye anatomy includes engaging a patient's head with a housing, positioning at least one camera coupled to the housing adjacent an eye, wherein the camera has a view vector along a first axis when in a first position, and moving the camera to a second position with a view vector along a second axis offset from the first axis.

Abstract: An ophthalmic imaging device (300) includes a fundus module (210) and a slit lamp 5 module (220) movably coupled to each other. The fundus module (210) includes an illumination module (230) and an imaging module (240). The illumination module (230) is adapted to yield a first partially blocked beam. The imaging module (240) includes a mirror (324) with a hole and an objective lens (326) to produce a reflected first partially blocked beam and a second partially blocked beam, to form a cornea 10 illuminating doughnut (502) and pupil illuminating doughnut (504), respectively, on an anterior region of the eye and form an image of the posterior\\region of the eye on an image plane (346). The slit lamp module (220) is adapted to view and capture the image of anterior and posterior regions of the eye.

Abstract: Systems and methods are disclosed herein for adjusting flash intensity based on retinal pigmentation. In an embodiment, a processor determines a retinal pigmentation of a retina of an eye positioned at an imaging device. The processor commands the imaging device to adjust an intensity of a flash component from a first intensity to a second intensity based on the retinal pigmentation. The processor commands the imaging device to capture an image that is lit by the flash component at the second intensity, and receives the image from the imaging device.

Abstract: A retinal imaging system includes a projector, an imaging device, and a controller coupled to an eye tracking system under test. The projector emits a light pattern to be delivered to a pupil of an eye, a location of the pupil being estimated by the eye tracking system under test. The imaging device captures one or more images of a retina of the eye illuminated with at least a portion of the light pattern. The controller determines one or more eye tracking parameters based on the captured one or more images of the retina. The controller compares each determined eye tracking parameter with each of estimated one or more eye tracking parameters, wherein values for the one or more eye tracking parameters are estimated by the eye tracking system under test. The controller characterizes each estimated eye tracking parameter based on the comparison.

Abstract: A non-mydriatic, non-contact ultra-widefield fundus (u-WF) photographic imaging system and method are provided for performing u-WF photographic imaging of the eye. The non-mydriatic, non-contact u-WF photographic imaging system includes an illumination system that delivers trans-pars-planar illumination to the eyeball. This frees the entire pupil to be used for imaging. Freeing the entire pupil to be used for imaging allows a u-WFC of the non-mydriatic, non-contact u-WF photographic imaging system to use a relatively simple optics system to capture an ultra-wide FOV. Eliminating the need to dilate the pupil and the need to make contact with the eye while performing imaging eliminates the many problems associated with mydriatic, contact-mode fundus imaging systems and methods. In addition, the system can be implemented in a way that makes it highly suitable for telemedicine applications in underserved areas where clinics and trained healthcare providers may not be available.

Abstract: A method for examining a driver of a vehicle. In accordance with the method, at least one part of at least one eye and/or at least one part of the face of the driver is captured using a monitoring unit. The data captured by the monitoring unit is evaluated and the visual perception capability of the driver is examined based on the captured data. The method may further include identifying the driver and operating devices of the vehicle using the captured data.

Abstract: A system for identifying structures in an eye of a subject. In embodiments of the invention, the system has a housing; a visible light source supported by the housing; an infrared light source supported by the housing; a photodetector supported by the housing; a patient interface disposed on an outer surface of the housing arranged and configured so that, when the patient interface is placed in contact with the subject, the subject's eye is aligned with the light sources and the photodetector such that the light sources illuminate an iris of the eye at an angle between 15° and 30° and such that the photodetector receives light from the light sources reflected by the iris; and a controller configured to activate the visible light source and the infrared light source and to obtain image information from the photodetector.

Abstract: A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.

Abstract: A system includes: a first movable stage which is movable with respect to an eye of a subject; a second movable stage mounted on the first movable stage, wherein the second movable stage is movable with respect to the first movable stage; a fixation target disposed on the second movable stage; and an optical system disposed in an optical path between the fixation target and the eye, wherein the optical system is configured for projecting the fixation target upon the eye to accommodate the eye, and wherein moving the second movable stage to a position where the fixation target is moved away from the eye by an additional amount causes blur cues of the fixation target to indicate to the subject that the fixation target is moving away from the eye while the size of an image of the fixation target on the retina of the eye decreases.

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

Abstract: A system includes: at least one processor; a movable stage, wherein the movable stage is movable under control of the at least one processor with respect to an eye of a subject; a video display device configured to move with the movable stage; and an optical system disposed in an optical path between the video display device and the eye. The video display device is configured to play a movie of a fixation target to the eye to cause the eye to accommodate, and the movie dynamically changes an appearance of the fixation target on the video display device to compensate for Bokeh of the fixation target as the movable stage moves the video display device from a first position, where the fixation target draws a focus of the eye to near its far point, to a second position further away from the eye than the first position.

Abstract: The present invention generally relates to an image-guided laser irradiation device for targeted ablation, stimulation, molecular delivery and therapy. Specifically, the invention relates to application of the device in therapies needing precise and targeted removal of a sample, or delivery of impermeable molecules for therapeutic outcome. More specifically, the invention relates to the application of the device in the therapy of visual disorders.

Abstract: An image acquisition unit (2) acquires an image obtained by capturing at least eyes of a target person. An object specifying unit (4) specifies an object in a line-of-sight direction of the target person using the acquired image. An incident light amount calculation unit (6) calculates an incident light amount representing an amount of light incident on the eyes of the target person using the acquired image. A reference pupil size determination unit (8) determines a reference pupil size based on the calculated incident light amount. A pupil size calculation unit (10) calculates a pupil size of the target person using the acquired image. An interest determination unit (12) determines an interest of the target person in the object by comparing the determined reference pupil size with the calculated pupil size.

Abstract: An eye measurement system includes an optical system. The eye measurement system is disposed in a housing which includes an aperture for providing light to and from the optical system and a subject's eye while the subject is separated and spaced apart from the housing, and the eye is not maintained in a fixed positional relationship with respect to the housing. An optical system movement arrangement moves the optical system. An automatic eye tracking arrangement ascertains a current positional relationship of the eye with respect to the optical system without human assistance, and in response thereto controls the optical system movement arrangement to move the optical system into a predetermined positional relationship with respect to the eye, for measurement of the eye, without human assistance. The eye measurement system can make objective, and/or subjective, refraction measurements of the eye.

Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: An example device is configured to capture an image of an eye. The device includes a camera configured to capture the image of the eye. The device also includes: a first base configured to be moved along a first axis to position the camera to capture the image of the eye; a second base configured to be moved along a second axis to position the camera to capture the image of the eye; and a third base configured to be moved along a third axis to position the camera to capture the image of the eye.

Abstract: Disclosed is a method of measuring a refractive error using a reflection image of a pupil for a visible ray, the method capable of diagnosing and self-examining a refractive error using only an image captured by a smartphone camera. The method may include obtaining an image by projecting a visible ray, using a flash, onto the retina of a subject and capturing, using a smartphone camera, a shape and location of the image reflected in the pupil of the subject, applying the image to a residual neural network (ResNet) model trained using data of an ImageNet based on clinical information into which result values of a refractive error of the subjects have been incorporated, and outputting the refractive error of the image and a measurement factor measured to determine the refractive error based on the shape and the location reflected in the pupil in a process of deriving the refractive error of the image.

Abstract: A handheld ophthalmic device configured to perform various optical diagnostic tests to determine the health of a subject's eye. The handheld ophthalmic device is configured to be attached to a smartphone, a cell phone or an electronic tablet. The smartphone, a cell phone or an electronic tablet can be used to view images obtained by the handheld ophthalmic device and to transmit data and images obtained by the handheld ophthalmic device to an ophthalmologist located remotely.

Abstract: A method for testing the eyes of a test person with the aid of a vision testing system as well as to a vision testing system, comprising a first measuring device, a second topographic measuring device, a third refractive measuring device and a processing means, a central axial length (LZ) and a peripheral axial length (LP) of an eye of the test person being measured with the aid of said first measuring device, a curvature of the cornea of the eye being measured with the aid of said second measuring device, a refractive property of the eye being measured with the aid of said third measuring device, measurement data of the measurements of the first, second and third measuring device being processed with the aid of said processing means, said processing means outputting the measurement data.

Abstract: An optical imaging system includes a first lens system housed in a body of a mobile telecommunication device, the first lens system having a first optical axis, a first entrance pupil fixed in space in a reference plane associated with said body, and a first focal length; and an optical telescope providing a diffraction-limited imaging within a spectral range from at least 486 nm to at least 656 nm. The optical imaging system is configured to image, when the optical telescope is inserted between the first lens system and an entrance pupil of a visual system of an eye (EPE), the EPE onto the first entrance pupil and vice versa with a substantially unit magnification.

Abstract: The present specification relates to Master-Slave (MS) interferometry for sensing the axial position of an object subject to optical coherence tomography (OCT) imaging, and to MS-OCT applied to curved and axially moving objects. The methods and apparatuses allow producing OCT signals from selected depths within the object irrespective of its axial position in respect to the imaging system. Images are obtained for curved objects that are flattened along a layer of interest in the object, images that are used to provide OCT angiography images less disturbed by axial movement or lateral scanning.

Abstract: The multi-scale scanning imaging system (200) of the retina comprises according to an example a lighting and detection module (210) configured for emitting a lighting beam and for detecting a beam reemitted by the retina, a first scanning module (231) of the lighting beam and the reemitted beam, a first optical path, referred to as a “wide field” path, and a second optical path, referred to as a “small field” path, for focusing the lighting beam on the retina and for receiving the beam reemitted by the retina. The “wide field” path comprises a first optical system (205, 201) configured to conjugate a plane located near a plane of rotation of the scanning module and the plane (17) of the entrance pupil of the eye (10).

Abstract: An optical imaging system includes a first lens system housed in a body of a mobile telecommunication device, the first lens system having a first optical axis, a first entrance pupil fixed in space in a reference plane associated with said body, and a first focal length; and an optical telescope providing a diffraction-limited imaging within a spectral range from at least 486 nm to at least 656 nm. The optical imaging system is configured to image, when the optical telescope is inserted between the first lens system and an entrance pupil of a visual system of an eye (EPE), the EPE onto the first entrance pupil and vice versa with a substantially unit magnification.

Abstract: An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

Abstract: A beam expander includes first and second optical elements spaced apart from each other, and a light diffuser having an angular aperture that diffuses incident light through the angular aperture, wherein the first optical element in-couples the diffused light such that light exiting the first optical element has a first cross-sectional shape and light having a second cross-sectional shape different from the first cross-sectional shape is incident on the second optical element, and the second optical element out-couples light incident from the first optical element.

Abstract: A visual performance examination device includes a display control unit that displays an indicator at each of a plurality of positions in a display screen of a display device; an image data obtaining unit that obtains an image data of eyes of a test subject, which are irradiated with a detection light emitted from a light source; a position calculating unit that, based on the image data, calculates a position data of corneal reflexes of the eyes when each of a plurality of indicators displayed at the positions in the display screen is shown; and an evaluating unit that, based on relative positions of the indicators and relative positions of the corneal reflexes, outputs evaluation data about visual performance of the test subject.

Abstract: A retinal imaging system includes an image sensor for acquiring a retinal image and an illuminator for illuminating a retina to acquire the retinal image. The illuminator surrounds an aperture through which an image path for the retinal image passes before reaching the image sensor. Illumination sources surround the aperture.

Abstract: A method of detecting injury to the brain such as stroke, concussion and cognitive dysfunction using a contrast agent and light source. The blood ocular barrier is disrupted when said injury occurs, allowing the entry of contrast agent into the aqueous and vitreous humor. An exemplary method comprises injecting a contrast agent into a peripheral location and then testing for leakage of contrast agent into the eye cavity by observing for light reflection, when a beam of light incidents on the contrast agent in the eye.

Abstract: A retinal imaging system includes a projector, an imaging device, and a controller coupled to an eye tracking system under test. The projector emits a light pattern to be delivered to a pupil of an eye, a location of the pupil being estimated by the eye tracking system under test. The imaging device captures one or more images of a retina of the eye illuminated with at least a portion of the light pattern. The controller determines one or more eye tracking parameters based on the captured one or more images of the retina. The controller compares each determined eye tracking parameter with each of estimated one or more eye tracking parameters, wherein values for the one or more eye tracking parameters are estimated by the eye tracking system under test. The controller characterizes each estimated eye tracking parameter based on the comparison.

Abstract: Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

Abstract: Retinal imaging systems and methods are described. In an embodiment, the retinal imaging system includes an eyepiece lens assembly; an image sensor adapted to acquire a retinal image of an eye through the eyepiece lens assembly; a dynamic fixation target optically coupled to the eyepiece lens assembly such that the dynamic fixation target is viewable through the eyepiece lens assembly; and a controller communicatively coupled to the image sensor and the dynamic fixation target. In an embodiment, the dynamic fixation target includes a display where an image generated by the display is controlled by a position of a user's eye relative to the eyepiece lens assembly.

Abstract: A processor or control circuit of an apparatus receives data of an image based on sensing by one or more image sensors. The processor or control circuit also detects a region of interest (ROI) in the image. The processor or control circuit then adaptively controls a light projector with respect to projecting light toward the ROI.

Abstract: A device and a method for the femtosecond laser surgery of tissue, especially in the vitreous humor of the eye. The device includes an ultrashort pulse laser with pulse widths in the range of approximately 10 fs-1 ps, especially approximately 300 fs, pulse energies in the range of approximately 5 nJ-5 ?J, especially approximately 1-2 ?J and pulse repetition rates of approximately 10 kHz-10 MHz, especially 500 kHz. The laser system is coupled to a scanner system which allows the spatial variation of the focus in three dimensions (x, y and z). In addition to the therapeutic laser/scanner optical system, the device includes a navigation system.

Abstract: A feature value related to a positional relationship between a vortex vein position and a characteristic point on a fundus image is computed. The image processing method provided includes a step of analyzing a choroidal vascular image and estimating a vortex vein position, and a step of computing a feature value indicating a positional relationship between the vortex vein position and a position of a particular site on a fundus.

Abstract: An optical coherence tomography apparatus includes a control unit configured, before a tomographic image to be stored is obtained using the output from the light receiving unit during a period in which the measurement light is scanned in a first scanning pattern for scanning an image capturing region of the subject eye, to control the optical scanning unit so as to repeatedly scan the measurement light in a second scanning pattern for scanning the measurement light over at least part of the image capturing region in a scanning time shorter than a scanning time of the first scanning pattern and to control the driving unit so as to drive the focusing unit using the output from the light receiving unit during a period in which the measurement light is repeatedly scanned in the second scanning pattern.

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

Abstract: An optical coherence tomography (OCT) scan device includes an OCT scan device housing, an interferometer disposed in within the OCT scan device housing and including a light source, a fiber optic coupler including an interferometer output, a reference-arm, and a sample-arm. The OCT scan device further includes a power source configured to provide power to the light source and the remaining components of the OCT scan device, and a controller disposed within the OCT scan device housing and configured to adjust lens focusing parameters in the reference-arm and the sample-arm, and control a scanning function of an optical beam emitting from the sample-arm. The OCT scan device is further configured to transmit and receive control instructions and transmit fundus image data.

Abstract: Disclosed herein are methods for simulating the results of a visual field (VF) test using an optical coherence tomography (OCT) system. The disclosed methods may utilize structural information extracted from OCT image datasets, such as thickness measurements, or may utilize functional information, such as blood perfusion measurements, extracted from OCT angiography (OCTA) image datasets. Other embodiments may be described and claimed.

Abstract: An ophthalmic scanning system includes a first imaging modality, a second imaging modality different from the first imaging modality, and a control system that maps the first imaging modality to the second imaging modality by compensating for at least one of an optical-mechanical and an electro-mechanical projection difference between the first and second imaging modalities. The control system provides a scan location for the second imaging modality based on a scan location of the first imaging modality.

Abstract: A system tracks eye movement using optical coherence in a head mounted display. The system includes an illumination source configured to project low coherence interference light onto a portion of a user's eye. The system includes a scanning system to select an axial position within the illuminated portion of the user's eye. The system includes a detector configured to collect light reflected from the illuminated portion of the user's eye at the selected axial position, and the reflected light includes measurement data characterizing the illuminated portion of the user's eye. The system includes a controller configured to compare the measurement data with a trained baseline, and determine an eye position based the comparison.

Abstract: Eye fundus inspection apparatus (500) comprising: —illumination means (12) comprising at least a light source (121, 123, 124, 126) and adapted to project a first light beam (1) towards a retina (101) of an eye (100); —an optical lighting path (1A) for said first light beam; —acquisition means (27) adapted to receive a second light beam (2) coming from the retina; —an optical acquisition path (2A) for said second light beam; —scanning means (17) adapted to scan said first light beam (1) on the retina with a linear movement, according to a first scanning direction (S1), or with a circular movement about a rotation axis (A), according to a second scanning direction (S2); —light beam separating means (16) adapted to define separate passage zones for said first and second light beams (1, 2) at a pupil of the eye; —a control unit (120) adapted to control operation of said inspection apparatus; —first light beam shaping means (11) and second light beam shaping means (23, 271, 272) that allow obtaining improved retin

Abstract: The present invention relates to aids or devices with optical elements which include a partially reflective surface, which allow examination or recordal of a patient who is fixated on a visual target, with said examination or recordal occurring along the same axis as the line of sight. The invention also allows for a target more personalised and customised to the patient's needs.

Abstract: A spectroreflectometric system for performing a spectral analysis on the fundus of a patient's eye or other medium is provided. The system includes an imaging device and a spectral analyser. Illumination light from an illumination light source is projected towards the fundus of the patient's eye. The resulting light from the fundus is separated by a beam splitter into an imaging portion travelling along an imaging light path to reach the imaging device and a spectral analysis portion deviated to a spectral analysis light path. The system further includes a pointer light source optically coupled to the spectral analysis light path. The system is operable in an acquisition mode to concurrently obtain an image of the fundus of the patient's eye and a spectral analysis of an analysis spot on this fundus, and in a pointer mode to obtain a visual representation of the analysis spot within the image.

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

Abstract: Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroidal recess; and an electrode having a distal end and a proximal end, the electrode being mounted to the elongated light pipe and extending proximally along the elongated light pipe so that the distal end of the electrode terminates at the spheroidal recess at the distal end of the elongated light pipe.

Abstract: An optical system for a laser therapy instrument for the application of laser radiation on and in the eye, includes a femtosecond laser, an objective. The objective or at least one lens or lens group of the objective is shiftable in the direction of the optical axis being intended for shifting of the focus position from the region of the cornea to the region of the crystalline lens and vice versa. The optical system may include at least two optical assemblies designed for the axial variation of the focus of the therapeutic laser radiation, with the focus variation range ?z differing between the individual assemblies and a changing device, designed for the insertion of any one of these assemblies into the therapeutic laser beam path at a time.