For Fluid Suspended Particles Patents (Class 356/243.2)
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Patent number: 11733252Abstract: One variation of a method includes, during a calibration period: triggering collection of an initial bioaerosol sample by an air sampler located in an environment; and triggering dispensation of a tracer test load by a dispenser located in the environment; accessing a detected barcode level of a barcode detected in the initial bioaerosol sample; accessing a true barcode level of the barcode contained in the tracer test load; and deriving a calibration factor for the environment based on a difference between the detected barcode level and the true barcode level. The method further includes, during a live period succeeding the calibration period: triggering collection of a first bioaerosol sample by the air sampler; accessing a detected pathogen level of a pathogen detected in the first bioaerosol sample; and interpreting a predicted pathogen level of the pathogen in the environment based on the detected pathogen level and the calibration factor.Type: GrantFiled: November 29, 2022Date of Patent: August 22, 2023Assignee: Poppy Health, Inc.Inventors: Sam D. Molyneux, Elizabeth Caley, Daniela Bezdan, Ricardo Vidal, Nathan Volman, Tae Joon Yi, Kevin Slavin
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Patent number: 10578541Abstract: The current invention concerns a flow cytometric system and method for observing, analyzing and/or separating objects in a liquid sample, comprising a digital holographic microscope (DHM) and at least one fluidic system, whereby the DHM comprises illumination means, an interferometric system and digital recording means, whereby the fluidic system is capable of guiding said objects through an illumination beam of the illumination means of said DHM, whereby the fluidic system comprises a mechanism for inducing a liquid sample stream through the fluidic system, whereby preferably the fluidic system comprises a stream size controlling device for controlling the transverse dimensions of a liquid sample stream inside said fluidic system, preferably said stream size controlling device is capable of lining up the objects one-by-one or multiple objects at a time in said liquid sample stream.Type: GrantFiled: February 3, 2013Date of Patent: March 3, 2020Assignee: Ovizio Imaging Systems NV/SAInventors: Serge Jooris, Philip Mathuis
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Patent number: 10416074Abstract: A calibration method for a spectrometer and a reference material which facilitates calibration of the spectrometer are provided. The reference material has a homogeneous content of elements protected by an inert coating.Type: GrantFiled: April 13, 2016Date of Patent: September 17, 2019Assignee: Heraeus Electro-Nite International N.V.Inventor: Luc Lammerant
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Patent number: 10132958Abstract: A technique includes acquiring dry condition and wet measurements using an optical spectrometer for a plurality of lamp intensities. The technique includes determining candidate maximum optical densities as a function of the lamp intensities based at least in part on a reference measurement that is acquired by the spectrometer, the reference measurement and does not vary with respect to the lamp intensities. The technique includes determining an optical density linear dynamic range based at least in part on the candidate maximum optical densities.Type: GrantFiled: July 14, 2016Date of Patent: November 20, 2018Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Yuehua Chen, Cong Wang
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Patent number: 10113903Abstract: An ambient light sensor of an electronic device is calibrated using a calibration device and method which combines multiple sources of light having different wavelengths into a single calibration beam of light. This calibration beam of light provides a consistent and reproducible methodology for testing and calibrating the ambient light sensor.Type: GrantFiled: September 2, 2014Date of Patent: October 30, 2018Assignee: AMAZON TECHNOLOGIES, INC.Inventors: Prashanth Basavaraj Patil, Jian Song
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Patent number: 9952134Abstract: An analytical instrument for cellular analysis of cellular particles tagged with elemental tags, such as lanthanide-based elemental tags. The analytical instrument has a sample introduction system for generating a stream of particles from the sample. An inductively coupled plasma ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The ion pretreatment system can filter out low mass ions, such as using a high-pass mass filter or a bandpass mass filter, to allow the elemental tags to pass therethrough. The mass analyzer is adapted to measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles.Type: GrantFiled: November 11, 2011Date of Patent: April 24, 2018Assignee: Fluidigm CorporationInventors: Dmitry R. Bandura, Vladimir I. Baranov, Scott D. Tanner
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Patent number: 9746404Abstract: A method and apparatus for inspection of liquids are disclosed. The method includes inspecting a liquid with a technique selected according to whether the package of the liquid is transparent, semi-transparent or opaque. If the package is transparent or semi-transparent, a Raman spectra technique is used; if the package is opaque, a technique using an electronic scale and a barcode reader is used. In some embodiments, the Raman spectra technique and the technique using barcode reader and electronic scale can be used independently for inspection of the liquid. The inspection apparatus according to the present disclosure has advantages, such as capability of material identification, rapid examination speed, small volume, light weight, portability, low cost, freedom from radiation, and simple maintenance. The method and apparatus according to the present disclosure are suitable for safety inspection in public places having a large number, and fast flow, of people.Type: GrantFiled: December 19, 2014Date of Patent: August 29, 2017Assignee: NUCTECH COMPANY LIMITEDInventors: Hongqiu Wang, Yumin Yi, Huacheng Feng, Rui Fan
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Patent number: 9506860Abstract: An apparatus for the calibration of optical measuring instruments with a carrier includes a calibration body having a glass body which has at least one scattering element, wherein the scattering element is completely surrounded by the glass body, and wherein a degree of transmission of the scattering element and of the glass body differ from one another.Type: GrantFiled: July 21, 2016Date of Patent: November 29, 2016Assignee: BYK-GARDNER GMBHInventor: Severin Wimmer
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Patent number: 9354218Abstract: An apparatus for the characterization of respirable aerosols, including: a burn chamber configured to selectively contain a sample that is selectively heated to generate an aerosol; a heating assembly disposed within the burn chamber adjacent to the sample; and a sampling segment coupled to the burn chamber and configured to collect the aerosol such that it may be analyzed. The apparatus also includes an optional sight window disposed in a wall of the burn chamber such that the sample may be viewed during heating. Optionally, the sample includes one of a Lanthanide, an Actinide, and a Transition metal.Type: GrantFiled: July 30, 2014Date of Patent: May 31, 2016Assignee: Consolidated Nuclear Security, LLCInventors: Douglas K. Clark, Bradley W. Hodges, Jesse D. Bush, Jofu Mishima
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Publication number: 20150124248Abstract: A Total Suspended Solids (TSS) Device which includes a plurality of calibrated sample containers in a case, such that each calibrated sample container contains a calibrated sample, wherein each calibrated sample is a sample with a known suspended solids concentration prepared from a site sample, such that said TSS device is configured to allow a discharge sample in a discharge sample container to be visually compared to each of the calibrated samples in the calibrated sample containers in said case, where the discharge sample is a sample of a liquid discharge from a site.Type: ApplicationFiled: June 5, 2013Publication date: May 7, 2015Inventor: Mark James TIPPER
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Patent number: 8994940Abstract: Disclosed is a fine particle measurement apparatus including a light condensing unit that condenses irradiated light irradiated to a sample flow where fine particles pass through and directly propagates the light without scattering, and scattered light scattered by the fine particles to an optical receiver divided into a plurality of regions; a position controller that controls the relative positions of members of an optical path; and a control unit that detects positions of condensing spots of the irradiated light and the scattered light based on signal intensities of each region of the optical receiver, and controls the position controller such that the positions of the condensing spots of the irradiated light and the scattered light match with each other.Type: GrantFiled: August 5, 2011Date of Patent: March 31, 2015Assignee: Sony CorporationInventors: Suguru Dowaki, Shingo Imanishi, Gakuji Hashimoto, Shunpei Suzuki
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Patent number: 8760650Abstract: A standard media suspension body (150) for verification and calibration of an optical particulate measurement instrument and configured to be at least partially immersed in a sample fluid is provided according to the invention. The body (150) includes a substantially solid outer surface including a first end (151) and a second end (152) disposed along an axis of illumination A and at least one outer surface (153). The first end (151) is configured to admit impinging light. The suspension body further includes an inner volume. At least a portion of the inner volume includes a substantially suspended light scattering material (155) that is configured to scatter a predetermined quantum of the admitted light. The suspension body (150) further includes an end cap (156) formed on the second end (152) and comprising a light absorbing material. Light exiting the second end (152) is substantially absorbed by the end cap (156).Type: GrantFiled: September 4, 2008Date of Patent: June 24, 2014Assignee: Hach CompanyInventor: Perry A. Palumbo
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Patent number: 8731860Abstract: Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.Type: GrantFiled: February 7, 2011Date of Patent: May 20, 2014Assignee: Cytonome/ST, LLCInventors: Johnathan Charles, Emanuel Tito Mendes Machado, Rudolf Hulspas
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Patent number: 8675196Abstract: An analyzer comprises: a sample stream forming section for forming a sample stream including particles; a light source; an optical fiber bundle formed by a plurality of optical fibers, into which light from the light source enters, and which emits light onto the sample stream; and an imaging device for imaging a particle in the irradiated sample stream.Type: GrantFiled: October 28, 2010Date of Patent: March 18, 2014Assignee: Sysmex CorporationInventor: Masatsugu Ozasa
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Publication number: 20130242296Abstract: A method and system for calibrating a flow cytometer to a refractive index X, the method comprising: analysing a first mixture of particles in the cytometer and recording the results produced, wherein the first mixture comprises particles having refractive index X, wherein the particles of refractive index X have a plurality of different sizes; analysing a second mixture of particles in the cytometer and recording the results produced, wherein the second mixture comprises particles having refractive index Y, wherein refractive index Y does not equal refractive index X, and wherein the particles of refractive index Y have a plurality of different sizes, wherein there is at least a partial overlap between the particle sizes in the first and second mixtures, and wherein the size of at least one particle of the second mixture is known; and using the results produced by the first and second mixture to calibrate the cytometer to refractive index X.Type: ApplicationFiled: February 27, 2013Publication date: September 19, 2013Applicant: OJK CONSULTING LTDInventor: Oliver KENYON
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Patent number: 8373854Abstract: The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.Type: GrantFiled: June 10, 2010Date of Patent: February 12, 2013Assignee: Applied Biosystems, LLCInventors: J. Michael Phillips, Kevin S. Bodner, Aldrich N. K. Lau, Steven J. Boege, Mark F. Oldham, Donald R. Sandell, David H. Tracy
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Publication number: 20120242993Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. The sensor comprises a disposable fluid conduit or reactor bag and a reusable sensor assembly. An optical bench or inset optical component is integrated within the disposable fluid conduit or bioreactor bag, which provides an optical light path through the conduit or bag. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the disposable fluid conduit or bag and on the reusable sensor assembly. Methods for calibrating the sensor and for determining a target property of an unknown fluid are also disclosed. The devices, systems and methods relating to the sensor are suitable for and can be outfitted for turbidity sensing.Type: ApplicationFiled: March 25, 2011Publication date: September 27, 2012Inventors: Karl G. Schick, David Uhen
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Patent number: 8158438Abstract: The invention relates to a method for the determination of the concentration of a non-volatile analyte in an aqueous sample medium, with the use of an optical sensor which contains a luminescent dye and is calibrated at the user site by means of a single-point-calibration. To enable the user to completely dispense with all calibration media a luminescence measurement value is obtained at the user site with the sensor in contact with the aqueous or bloodlike sample medium, which value is referenced to the relative characteristic obtained at the factory site and to a measured dry calibration value obtained at the user site, the concentration of the non-volatile analyte being deduced from these data.Type: GrantFiled: July 4, 2006Date of Patent: April 17, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Marco Jean-Pierre Leiner, James Kenneth Tusa
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Patent number: 8102528Abstract: The present invention provides a particle standard including particles having optical properties similar to those of a carrier in which the particles are dispersed, as well as a method of calibrating or validating a subject optical particle analyzer with respect to a reference optical particle analyzer by using the particle standard. In the method, the particle standard is analyzed with the reference optical particle analyzer to obtain a reference particle concentration and a reference particle-size distribution. Analogously, the particle standard is analyzed with the subject optical particle analyzer to obtain a subject particle concentration and a subject particle-size distribution. The subject particle concentration and the subject particle-size distribution are then compared to the reference particle concentration and the reference particle-size distribution, respectively, and the subject optical particle analyzer is adjusted accordingly.Type: GrantFiled: August 28, 2009Date of Patent: January 24, 2012Assignee: Brightwell Technologies Inc.Inventors: Clark Adrien Merchant, Peter Oma
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Publication number: 20110235030Abstract: A method and a device employing the method of flow cytometry, preferably applicable but not limited to the counting and differentiation of leukocytes. It relates more particularly to the field of simplified haematology instruments with moderate operating costs. The method is characterized in that a technique of impedance measurement is used for identifying the particles whose trajectory did not pass through a predetermined optical measurement zone in order to process them selectively, thus avoiding the use of sheath fluids for guiding the particles towards the measurement zone.Type: ApplicationFiled: December 1, 2009Publication date: September 29, 2011Applicant: C2 DIAGNOSTICSInventors: Henri Champseix, Olivier Magnin, Bernard Welmant
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Publication number: 20110196637Abstract: Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Applicant: CYTONOME/ST, LLCInventors: Johnathan C. Sharpe, Emanuel Tito Mendes Machado, Rudolf Hulspas
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Publication number: 20110085168Abstract: The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.Type: ApplicationFiled: June 10, 2010Publication date: April 14, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: J. Michael Phillips, Aldrich N.K. Lau, Mark F. Oldham, Kevin S. Bodner, Steven J. Boege, Donald R. Sandell, David H. Tracy
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Patent number: 7843560Abstract: The present invention relates to a turbidity calibration standard comprising: a number of from 1 to 5 sequentially-interfaced layers, wherein each layer independently comprises a light-permeable polymer or light-permeable interpolymer; a measured light transmission modulating amount of at least one light transmission modulator, which is distributed in any one or more of the layers; and a light-permeable container, which contains the layers and the at least one light transmission modulator. Also, the invention relates to methods of making and using the standard, and kits comprising the standard.Type: GrantFiled: August 21, 2008Date of Patent: November 30, 2010Assignee: Dow Global Technologies Inc.Inventors: Richard S. Harner, J. Keith Harris, William A. Heeschen, Mary Beth Seasholtz
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Patent number: 7820428Abstract: A field deployable optical assembly for use in testing a light-responsive sample is disclosed. The assembly includes a microfluidic device, a first optical package, and a second optical package. The first optical package includes a light emitting diode (LED), a first optical device, and a first light-path control, the first optical package configured to guide and focus light from the LED onto the sample. The microfluidic device includes a tethered control substance. In response to a substance within the sample being associated with, and attaching to, the tethered control, the sample emits light. The second optical package includes a photo sensor, a second optical device, and a second light-path control, the second optical package configured to guide and focus the light emitted from the sample onto the photo sensor.Type: GrantFiled: June 29, 2006Date of Patent: October 26, 2010Assignee: General Electric CompanyInventors: Steven Tysoe, Eugene Barash, Thomas Stecher
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Publication number: 20100259756Abstract: A sensor head for a dry powder agent according to an exemplary aspect of the present disclosure includes a housing defined along an axis along which light is communicated, the housing defines a multiple of apertures transverse to the axis, the multiple of apertures in communication with a measurement volume along the axis. A mirror is within the housing to reflect the light through the measurement volume.Type: ApplicationFiled: April 9, 2009Publication date: October 14, 2010Inventors: Brian Powell, Scott Ayers
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Publication number: 20100235133Abstract: A standard media suspension body (150) for verification and calibration of an optical particulate measurement instrument and configured to be at least partially immersed in a sample fluid is provided according to the invention. The body (150) includes a substantially solid outer surface including a first end (151) and a second end (152) disposed along an axis of illumination A and at least one outer surface (153). The first end (151) is configured to admit impinging light. The suspension body further includes an inner volume. At least a portion of the inner volume includes a substantially suspended light scattering material (155) that is configured to scatter a predetermined quantum of the admitted light. The suspension body (150) further includes an end cap (156) formed on the second end (152) and comprising a light absorbing material. Light exiting the second end (152) is substantially absorbed by the end cap (156).Type: ApplicationFiled: September 4, 2008Publication date: September 16, 2010Applicant: Hach CompanyInventor: Perry A Palumbo
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Publication number: 20100231908Abstract: The size of particles is detected accurately and at low cost even when there are few microparticles as impurities included in a liquid. Provided is a method of detecting a size of particles in a liquid by detecting diffraction fringes appearing due to the particles in the liquid by a light detection portion. Diffraction fringes are detected by a first light detection portion and a second light detection portion that are separated along the flow direction of the liquid. A peak time difference (T2) that is a difference between times at which peak values appear in a detection signal from the first and second light detection portion is measured, and an area (SQ) based on the waveform of the detection signal is measured. The sizes of the particles included in the liquid are detected based on the peak time differences (T2) and the areas (SQ) that were measured.Type: ApplicationFiled: May 5, 2010Publication date: September 16, 2010Inventors: Koichi NAKANO, Yasuhiro Hayashi
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Patent number: 7742164Abstract: The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.Type: GrantFiled: December 18, 2008Date of Patent: June 22, 2010Assignee: Applied Biosystems, LLCInventors: J. Michael Phillips, Aldrich N. K. Lau, Mark F. Oldham, Kevin S. Bodner, Steven J. Boege, Donald R. Sandell, David H. Tracy
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Publication number: 20090308133Abstract: The present invention provides a particle standard including particles having optical properties similar to those of a carrier in which the particles are dispersed, as well as a method of calibrating or validating a subject optical particle analyzer with respect to a reference optical particle analyzer by using the particle standard. In the method, the particle standard is analyzed with the reference optical particle analyzer to obtain a reference particle concentration and a reference particle-size distribution. Analogously, the particle standard is analyzed with the subject optical particle analyzer to obtain a subject particle concentration and a subject particle-size distribution. The subject particle concentration and the subject particle-size distribution are then compared to the reference particle concentration and the reference particle-size distribution, respectively, and the subject optical particle analyzer is adjusted accordingly.Type: ApplicationFiled: August 28, 2009Publication date: December 17, 2009Inventors: Clark Adrien MERCHANT, Peter Oma
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Patent number: 7518719Abstract: A method and apparatus for detecting contaminants in hydrocarbon fuel are disclosed, wherein a fuel analyzer includes a flow sensor to facilitate an automatic start up and shut down of a fuel analysis, and a calibration standard to facilitate an inline calibration of the fuel analyzer.Type: GrantFiled: January 25, 2007Date of Patent: April 14, 2009Assignee: Velcon Filters, Inc.Inventors: Greg Sprenger, Jed Stevens, Michael White, Richard Hillis, Jacob Lavenberg, Chris Templeman
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Publication number: 20090059218Abstract: The present invention relates to a turbidity calibration standard comprising: a number of from 1 to 5 sequentially-interfaced layers, wherein each layer independently comprises a light-permeable polymer or light-permeable interpolymer; a measured light transmission modulating amount of at least one light transmission modulator, which is distributed in any one or more of the layers; and a light-permeable container, which contains the layers and the at least one light transmission modulator. Also, the invention relates to methods of making and using the standard, and kits comprising the standard.Type: ApplicationFiled: August 21, 2008Publication date: March 5, 2009Inventors: Richard S. Harner, J. Keith Harris, William A. Heeschen, Mary Beth Seasholtz
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Patent number: 7162057Abstract: Apparatus for monitoring particulate material in a fluid comprising a passageway (17), through which fluid to be monitored is passed, at least a portion (24) of the boundary of the passageway (17) being translucent to enable radiation to pass through that portion (24). A camera (40) is arranged to receive such radiation and is constructed to generate electrical signals representative of the images it receives. Image analysis means (57) are connected to receive those electrical signals and to provide data from them relating to the particulate material contained within the fluid.Type: GrantFiled: March 2, 2000Date of Patent: January 9, 2007Assignee: Jorin LimitedInventors: Nicholas James Roth, John Robert Roth, Roderick Clive Gaskin
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Patent number: 6629449Abstract: Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer, respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble.Type: GrantFiled: March 26, 2002Date of Patent: October 7, 2003Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Robert Kline-Schoder, Patrick J. Magari
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Patent number: 6327889Abstract: A convenient apparatus and method for inserting surrogate metal-entraining aerosols into exhaust stacks for the purpose of realistic dynamic testing of an emissions monitor. The aerosols contain elements required to be detected by the monitor. The 14 metals regulated by the EPA as hazardous air pollutants are of particular interest. The method requires less time and fewer skilled technicians than conventional testing methods. In a preferred embodiment of the present invention, a burner (e.g., propane or kerosene) is combined with a combustion chamber, a fan, an air compressor, at least one peristaltic pump, at least one surrogate reservoir, and the necessary ductwork for connection to an exhaust stack. The amount of surrogate aerosol to be introduced to the stack is adjusted at the peristaltic pump. After heating by the burner and subsequent introduction into the hot stack, the surrogate homogeneously mixes with the exhaust stream and is presented to the sensor as a dry gas component of the exhaust stream.Type: GrantFiled: December 20, 1999Date of Patent: December 11, 2001Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael D. Seltzer, Gerhard A. Meyer