Sample, Specimen, Or Standard Holder Or Support (e.g., Plates Or Slides) Patents (Class 356/244)
  • Patent number: 10345548
    Abstract: The disclosure provides an optical apparatus including at least one optical element including glass, at least one support including silicon and a housing including glass. Furthermore, the at least one optical element and the at least one support can be anodically bonded together, and the at least one support and the housing can be anodically bonded together. The disclosure further provides a method for fabricating optical components with durable bonds and incorporates active alignment.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: July 9, 2019
    Inventors: Nezih Dural, Michael V Romalis
  • Patent number: 10330601
    Abstract: The disclosure relates to a method for detecting single molecules on an object. The method includes: providing a carrier; attaching the carrier on a surface of the object so that the surface of the object is indirect contact with the carrier; and detecting the single molecules on the object with a detector. The carrier includes a flexible substrate and a metal layer on the flexible substrate. The flexible substrate includes a base and a bulge pattern located on a surface of the base. The bulge pattern includes a number of strip-shaped bulges intersecting with each other to form a net and define a number of recesses. The metal layer is located on the bulge pattern. The carrier has a relative higher SERS and can enhance the Raman scattering.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: June 25, 2019
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ying-Cheng Wang, Yuan-Hao Jin, Qun-Qing Li, Shou-Shan Fan
  • Patent number: 10302412
    Abstract: An apparatus includes a lighting unit configured to irradiate a light emitting device package including a light transmitting resin containing a light conversion material with light having a certain color; a camera configured to capture an image of the light emitting device package; and a controller configured to determine color coordinates of the light emitting device package using the image, captured by the camera, to determine whether the light emitting device package is defective.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: May 28, 2019
    Inventors: Young Hyo Eun, Ju Hyun Song, Jae Sung Kim, Tae Hee Song, Shin Min Rhee
  • Patent number: 10295822
    Abstract: A method for producing a contrast-amplifying support comprising an absorbing substrate carrying at least one absorbing layer comprises a design step for the support and the following steps: i) choosing an illumination wavelength ?; ii) choosing a material constituting the substrate and exhibiting, at illumination wavelength ?, a complex refractive index N0=n0?jk0 with k0?0.01; iii) choosing an ambient medium in contact with the layer on the side opposite to the substrate and exhibiting, at illumination wavelength ?, a complex refractive index N3=n3?jk3 with k3?0; iv) determining a nominal complex refractive index N1=n1?jk1 and a nominal thickness e1 of the layer wherein it behaves in the guize of antireflection layer when illuminated under normal incidence at illumination wavelength ?; and v) choosing a material constituting the layer and exhibiting, at illumination wavelength ?, a complex refractive index whose real and imaginary parts coincide with the nominal complex refractive index.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 21, 2019
    Inventors: Dominique Ausserre, Claude Amra, Myriam Zerrad, Refahi Abou Khachfe
  • Patent number: 10281365
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: May 7, 2019
    Assignee: Aquaro Histology, Inc.
    Inventors: Collin Rich, Nolan Orfield, Vincent Alessi
  • Patent number: 10268031
    Abstract: The present invention relates to digital pathology. In order provide enhanced use of available imaging radiation, a digital pathology scanner (10) is provided that comprises a radiation arrangement (12), a sample receiving device (14), an optics arrangement (16), and a sensor unit (18). The radiation arrangement comprises a source (20) that provides electromagnetic radiation (22) for radiating a sample received by the sample receiving device. Further, the optics arrangement comprises at least one of the group of a lens (24) and a filter (26) that are arranged between the sample receiving device and the sensor unit. The sensor unit is configured to provide image data of the radiated sample. Still further, a lens array arrangement (28) is provided that comprises at least one lens array (30) arranged between the source and the sample receiving device.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 23, 2019
    Inventors: Marius Iosif Boamfa, Reinhold Wimberger-Friedl, Theodoor Bastiaan Johannes Haddeman
  • Patent number: 10247743
    Abstract: The type of blood collection tube (1) inserted into this system is automatically recognized, a lifting operation for checking the state and volume of analyte is switched on the basis of the automatic recognition result, a mechanical operation parameter based on the blood collection tube type is determined, and the blood collection tube (1) is grasped and lifted. Then, an image processing threshold is changed on the basis of the automatic recognition result, and image processing is performed using a threshold parameter based on the blood collection tube type to check the state and volume of the analyte. This enables precise automatic checking of the state and/or volume of the analyte for various types of blood collection tubes.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: April 2, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Iwao Suzuki, Tsukasa Suenari, Takahiro Sasaki, Kenichi Takahashi
  • Patent number: 10240917
    Abstract: A measuring apparatus according to the present disclosure includes a support plate and an optical sensor. The support plate has an upper surface on a central portion of which an object is to be mounted, and is rotatable about an axis of rotation extending vertically from the central portion. The optical sensor is disposed above the support plate, and has a light-emitting element configured to irradiate the object with light and a light-receiving element configured to receive reflection light reflected from the object.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: March 26, 2019
    Assignee: Kyocera Corporation
    Inventors: Tomoya Yamada, Taku Matsudera
  • Patent number: 10241024
    Abstract: Described are systems and methods for optical characterization of inclusions, such as solids and liquids, in liquid samples. An inclusion characterization system may include a radiation source, a radiation detector, a sample optical cell, and a sample delivery mechanism. The radiation detector may be configured to perform time resolved measurements. The sample may be delivered to the sample optical cell by the sample delivery mechanism at a flow rate set for preserving the sample integrity (i.e., the transport rate). The inclusion characterization in the sample may be performed at flow rates set for sample analysis (i.e., the analysis rate). The analysis rate may differ from the transport rate. The rate difference may be achieved by diverting only a portion of the overall sample into the sample optical cell. Also provided are examples of disengagement of sample transport and analysis flow rates.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: March 26, 2019
    Inventor: Rashid Mavliev
  • Patent number: 10241011
    Abstract: The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: March 26, 2019
    Assignees: The Scripps Research Institute, Engineering Arts LLC
    Inventors: Bridget Carragher, Clinton S. Potter, Tilak Jain, Peter Kahn, Peter Wiktor
  • Patent number: 10227583
    Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: March 12, 2019
    Inventors: Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford
  • Patent number: 10199198
    Abstract: A method of electron microscopy imaging of samples, using an electron microscope (100) having a microscope column (10) and a transfer device (11) with a grid carriage (12), comprises the steps of preparing multiple samples (1) on a single electron microscopy grid (2), including dispensing the samples (1) with a dispenser device (30) on distinct positions on the grid (2), introducing the grid (1) with the transfer device (11) into the microscope column (10), and electron microscopy imaging of the samples (1), wherein the preparing step includes holding the grid (2) on the grid carriage (12) of the transfer device (11) or on a grid holder device (20) provided at the electron microscope (100) and dispensing the samples (1) on the grid (2) while holding it on the grid carriage (12) or on the grid holder device (20). Furthermore, an electron microscope (100) for electron microscopy imaging of samples is described.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Scienion AG
    Inventors: Claude Dufresne, Holger Eickhoff
  • Patent number: 10175155
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: January 8, 2019
    Assignee: Aquaro Histology, Inc.
    Inventors: Nolan Orfield, Collin Rich, Vincent Alessi
  • Patent number: 10139348
    Abstract: A lightguide aggregate inspection device includes a reaction spot array including multiple reaction spot array elements having at least one reaction spot, a light-receiving element array having a light-receiving surface provided with multiple light-receiving regions each having at least one light-receiving element corresponding to each of the reaction spot array elements, and receiving light obtained based on an optical state resulting from reaction in each of the reaction spots, multiple lightguide paths provided to correspond to the reaction spot array elements, and each having a measurement end provided close to or in contact with, or to be movable close to or into contact with 1 reaction spot, and a connection end provided close to or in contact with the light-receiving region, and a digital data conversion unit configured to convert image region data obtained from the light-receiving elements corresponding to the light-receiving regions, into digital data.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: November 27, 2018
    Inventor: Hideji Tajima
  • Patent number: 10132742
    Abstract: The present invention relates to a probe unit comprising a probe (2) having a probe window (3) having a contact surface for facing a high pressure fluid flow, the probe unit comprising a probe housing (1) containing the probe including the probe window, the probe being moveable relative to the probe housing between a first position wherein the window is exposed to the fluid flow and a second position wherein the probe is enclosed by said housing and a space (11) is defined between said housing and said probe, said housing having an outer part into said fluid flow, said probe unit comprising sealing means (4, 5, 7) adapted to seal said defined space from said fluid flow when the probe is in said second position. The probe unit also comprises pressure adjustment means for reducing the pressure within said space and cleaning means (6, 9) for cleaning said probe when within said space.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: November 20, 2018
    Assignee: ProAnalysis AS
    Inventors: Stian Magnussen, Hallvard Tangen, Anders Dalland, Bjørn Atle Øverland, Sindre Rognved Hansen, Øyvind Smith-Jahnsen
  • Patent number: 10119889
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: November 6, 2018
    Assignee: Aquaro Histology, Inc.
    Inventors: Collin Rich, Nolan Orfield, Vincent Alessi
  • Patent number: 10119964
    Abstract: A device termed the MobileArray™ device and methods, which form the MobileArray™ system, are disclosed for performing multiplex assays, target enrichment or purification. The device and methods disclosed enable the performing of multiplex assays, target enrichment or purification in a simplified manner. The MobileArray™ device gains the advantages and applications of the advanced multiplexing platforms, but does not require the special expensive equipment, reagents, software or dedicated operators. In addition, the MobileArray™ system can also be utilized in immunoprecipitation and target enrichment or purification in a multiplex manner. Furthermore, the MobileArray™ system can be integrated in an automated procedure. The MobileArray™ system makes it possible to apply multiplexing protocols in routine clinical practice, food safety inspection and general life science research laboratories.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: November 6, 2018
    Assignee: Digital Biotech, LLC
    Inventor: Raymond Lesser
  • Patent number: 10094764
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 9, 2018
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Patent number: 10082653
    Abstract: A system for performing quantitative phase-contrast confocal microscopy includes a light source that emits light, a first beam splitter that splits the emitted light into an illumination path and a hologram path, means provided along the illumination path for delivering a first part of the emitted light to an object as a collimated line, a light sensor that captures light reflected off of the object to obtain an intensity image for the collimated line, and means provided along the hologram path for delivering a second part of the emitted light to the light sensor at an off-axis angle to obtain an off-axis hologram for the collimated line.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: September 25, 2018
    Assignee: University of South Florida
    Inventors: Changgeng Liu, Myung K. Kim
  • Patent number: 10047331
    Abstract: A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally molded with the carrier structure from a thermoplastic material.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 14, 2018
    Inventors: Jonas Lerche Hansen, Niels B. Ramsing, Søren Porsgaard, Holger Søe Plougsgaard, Mai Faurschou Isaksen
  • Patent number: 10000790
    Abstract: The subject invention provides materials and methods for detecting the presence of an electron donor. In a specific embodiment, the device detects the presence of dihydronicotinamide adenine dinucleotide (NADH) via a colorimetric change output by the sensing device. In another specific embodiment, the presence of an enzyme capable of catalyzing, or an agent capable of inhibiting, the production of NADH can also be detected by a colorimetric readout using the same device. In some embodiments, dihydronicotinamide adenine dinucleotide phosphate (NADPH) can also be detected using the device provided herein. Advantageously, preferred embodiments of the subject invention provide a low-cost, sensitive device for monitoring the presence of critical biological analytes in a variety of applications.
    Type: Grant
    Filed: June 28, 2015
    Date of Patent: June 19, 2018
    Inventors: Pingping Liang, Haixiang Yu, Yi Xiao
  • Patent number: 10003363
    Abstract: An apparatus for transferring data from a first part of a measuring apparatus to a second part includes a signal transmitting part mounted to the second part and having first antennae for receiving first electrical signals representing data from the second part and emitting electromagnetic radiation corresponding to the first electrical signals, and a signal receiving part mounted to the first part but separated from and rotating relative to the signal transmitting part. The signal receiving part includes a second antenna for receiving electromagnetic radiation and generating second electrical signals corresponding to the first electrical signals.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: June 19, 2018
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Marco Panniello, Emanuele Ronchi, Carl Robert Tipton
  • Patent number: 9989470
    Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: June 5, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Chinmay Pangarkar, Karan Mohan
  • Patent number: 9971138
    Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 15, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Michael Griffin, Daniel Yue Man Chu, Tom McCollum
  • Patent number: 9971133
    Abstract: In order to provide a multireflection cell making it possible to decrease the volume of a cell main body into which measurement target gas is introduced as well as reducing the amount of light that is lost without being reflected in a multireflection mechanism, the multireflection cell includes the multireflection mechanism adapted to multiply reflect incident light and then emit the multiply reflected light outward. In addition the multireflection mechanism includes a field mirror, a first objective mirror that faces to the field mirror and is provided on a light incident side in the multireflection mechanism, and a second objective mirror that faces to the field mirror and is provided on a light emitting side in the multireflection mechanism. Further, the light incident into the multireflection mechanism is configured to be first reflected by the second objective mirror.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 15, 2018
    Assignee: HORIBA, Ltd.
    Inventor: Takeshi Akamatsu
  • Patent number: 9958467
    Abstract: Provided is a method for supplementing a sample with specific information. This method includes the following steps: intrinsically marking a sample by adding a chemical marker having a defined composition to the sample; storing data reflecting the composition of the chemical marker and information assigned to the chemical marker, wherein this marker-assigned information is not related to the composition of the chemical marker itself; analyzing the sample with an analysis method, wherein the analysis method is suited to detect the composition of the chemical marker, to obtain a marker-related result; comparing the marker-related result with the stored data; and assigning the marker-assigned stored information to the sample based on the preceding comparison.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: May 1, 2018
    Assignee: numares AG
    Inventors: Fritz Huber, Volker Pfahlert, Markus Fuhrmann, Renate Kirchhöfer
  • Patent number: 9952128
    Abstract: The invention provides systems or apparatuses for dispensing aqueous materials for electron microscopy (EM). The systems allow dispensing of aqueous materials onto an EM sample grid at individual specimen locations in an ordered array of specimen locations, with each individual specimen location in the array of locations. The systems contain a holder for reversibly receiving an EM sample grid, and a dispenser containing one or more dispensing elements that are configured to discretely dispense one or more aqueous solutions from the dispensing elements onto a plurality of individual specimen locations. The dispenser is able to provide an ordered array of discrete specimen locations discontinuous with one another. In the systems, at least one dispensing element is configured to dispense picoliter volumes of one or more of the aqueous solutions.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: April 24, 2018
    Assignee: The Scripps Research Institute
    Inventors: Bridget Carragher, Clinton S. Potter, Tilak Jain
  • Patent number: 9939354
    Abstract: The present application discloses methods and apparatus for preparing blood film or smear samples on a fiber surface, staining the test sample, and generating digital cell images of the films or samples for classification and review. The techniques disclosed herein replace conventional microscope slides with fibers when preparing blood film test samples. Using fibers to prepare blood test samples facilitates automation and integration of the various processes involved in hematology analysis. The techniques disclosed herein can be used to improve the accuracy and efficiency of hematology analysis.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: April 10, 2018
    Inventor: Chen Yi
  • Patent number: 9939366
    Abstract: In one aspect, a spectrometer insert is provided. The spectrometer insert includes: an enclosed housing; a first transparent window on a first side of the enclosed housing; a second transparent window on a second side of the enclosed housing, wherein the first side and the second side are opposing sides of the enclosed housing; and a sample mounting and heating assembly positioned within an interior cavity of the enclosed housing in between, and in line of sight of, the first transparent window and the second transparent window. A method for using the spectrometer insert to locally heat a sample so as to measure temperature-dependent optical properties of the sample is also provided.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: April 10, 2018
    Assignee: International Business Machines Corporation
    Inventors: Nestor A. Bojarczuk, Talia S. Gershon, Teodor K. Todorov, Theodore G. van Kessel
  • Patent number: 9933428
    Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: April 3, 2018
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Eugene Chan, Keith Nassif
  • Patent number: 9933409
    Abstract: A strip connector includes a connector housing having a housing cavity and guide feature. A strip carrier slidable in the housing cavity includes a carrier body having a strip channel slidably receiving a test strip in an insertion direction. A first biasing member biases the strip carrier in an ejection direction opposite the insertion direction. A second biasing member acting orthogonal to the first biasing member biases the carrier body in a contact direction orthogonal to the ejection direction. First and second male members of the carrier body slide with respect to the guide feature and prevent strip contact direction carrier displacement until the male members are axially aligned with guide feature branches extending orthogonally to the guide feature. A test strip conductor contacts connector housing electrical contacts when the male members axially align with the branches and the second biasing member displaces the strip carrier in the contact direction.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: April 3, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Frederick Leland Wittekind, III
  • Patent number: 9927336
    Abstract: Apparatus and methods for performing small angle X-ray scattering (SAXS) at low (cryogenic) temperatures for determining the structure of and changes in the structure of proteins, DNA, RNA, and other biological molecules and biomolecular assemblies and structures. A cryogenic, small angle X-ray scattering (SAXS) application sample holder, includes a sample cell including a base portion and at least two parallel walls disposed on the base, wherein the sample cell has a liquid volume capacity defined by the walls and the base portion of 0.001 to 10 microliters.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: March 27, 2018
    Inventors: Stephen P. Meisberger, Matthew A. Warkentin, Jesse B. Hopkins, Andrea M. Katz, Lois Pollack, Robert E. Thorne
  • Patent number: 9921101
    Abstract: A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are likewise provided, operatively interposed before or after the objective lens as the case may be.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: March 20, 2018
    Inventors: Adnanul Haq, Richard J. Schoeneck
  • Patent number: 9909099
    Abstract: An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 6, 2018
    Assignee: Regents of the University of Minnesota
    Inventors: Allison Hubel, Jacob Hanna
  • Patent number: 9885665
    Abstract: The device serves for the qualitative and quantitative detection of particles in a fluid and includes a light source (1), an optical sensor (2) and a sample carrier (4) which is arranged therebetween and which is for receiving fluid to be examined. The sample carrier is (4) movable relative at least to the sensor (2) and is connectable via a fluid inlet (9) to a conduit (11) for feeding the fluid, and via a fluid outlet (10) to a conduit (12) for the discharge of fluid. The sample carrier (4) is exchangeably arranged in a receiver of the device, so that this sample carrier can be replaced by another one in a rapid and simple manner when the sample carrier (4) is contaminated.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: February 6, 2018
    Inventors: Kåre Iversen, Mathis Dahlqvist, Christian Guldbæk Smith
  • Patent number: 9880287
    Abstract: A method of imaging analyte elements in an organic sample includes providing the sample as a layer on a substrate and reacting the sample on the substrate to produce one or more volatile products that leave the sample while the one or more elements remain in the sample. A majority of the sample layer by weight is removed from the substrate by the reaction and the remaining sample layer is enriched in the one or more elements which are not spatially disturbed by the reaction. The method including subsequently detecting the one or more elements in the concentrated sample layer using an imaging elemental analyzer.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: January 30, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander A. Makarov, Johannes Schwieters
  • Patent number: 9849436
    Abstract: A microfluidic device includes a channel through which a reaction solution flows. The channel passes through a reaction section having a plurality of temperature zones set at predetermined different temperatures. The channel includes, at least in the reaction section, a region where a cross-sectional area decreases in a feeding direction of the reaction solution.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: December 26, 2017
    Inventors: Hiroaki Tachibana, Eiichi Tamiya, Masato Saito
  • Patent number: 9851310
    Abstract: A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: December 26, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Ian Burgess, Lidiya Mishchenko, Benjamin Hatton, Marko Loncar
  • Patent number: 9851305
    Abstract: A SERS unit 1A comprises a SERS element 2 having a substrate 21 and an optical function part 20 formed on the substrate 21, the optical function part 20 for generating surface-enhanced Raman scattering; a transportation board 3 supporting the SERS element 2 during transportation, the SERS element 2 being removed from the transportation board 3 upon measurement; and a holding part 4 having a pinching part 41 pinching the SERS element 2 in cooperation with the transportation board 3, and detachably holding the SERS element 2 in the transportation board 3.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: December 26, 2017
    Inventors: Masashi Ito, Katsumi Shibayama, Kazuto Ofuji, Hiroki Oyama, Yoshihiro Maruyama
  • Patent number: 9846123
    Abstract: A surface-enhanced Raman scattering element comprises a substrate having a principal surface; a molded layer including a support part formed on the principal surface and a fine structure part formed on the support part; and a conductor layer, deposited on the fine structure part, constituting an optical functional part for generating surface-enhanced Raman scattering. The fine structure part has a plurality of pillars erected on the support part. The support part is provided with a plurality of opposing parts opposing side faces of the pillars. The opposing parts are located on the substrate side relative to leading end parts of the pillars in a projecting direction of the pillars.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: December 19, 2017
    Inventors: Masashi Ito, Katsumi Shibayama, Yoshihiro Maruyama
  • Patent number: 9841422
    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 12, 2017
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: David A. Goldberg, David C. Howson, Steven W. Metzger, Daniel A. Buttry, Steven Scott Saavedra
  • Patent number: 9829430
    Abstract: A spectrophotometer includes: a sample-chamber lid capable of opening and closing an opening portion of a sample chamber for setting a sample and a reference sample; and sample-chamber lid opening-closing detecting means for detecting an opening-closing state of the sample-chamber lid, and the spectrophotometer is capable of controlling a measurement of a xenon flash tube as a light source, a spectroscope, a detector, an amplifier, an AD converter, a processor, a storage device, and a data display part. In the spectrophotometer, the light source is turned on after a state of the lid changing from an opening state to a closing state is detected in a sample-setting instruction state by the sample-chamber lid opening-closing detecting means; absorbancy, transmissivity, reflectivity, a sample-side energy value, or a reference-side energy value is measured; and a measurement result is displayed on the data display part.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: November 28, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takayuki Wakui, Hayato Tobe, Koichi Nakamura, Koji Yamamoto
  • Patent number: 9823222
    Abstract: A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: November 21, 2017
    Assignee: Advanced Analytical Technologies, Inc.
    Inventors: Ho-ming Pang, Wei Wei
  • Patent number: 9817027
    Abstract: In the field of the counting of objects, a use is provided of a photosensitive assembly comprising at least one photodiode or one photoresistor, and a source of uniform illumination for illuminating the assembly, the establishment of a reference current supplied by the photosensitive assembly for an illuminated region of this assembly corresponding to a given fraction of the surface of the assembly, the disposition of objects to be counted against the photosensitive assembly, the illumination of the assembly by the source, the objects masking a part of the surface of the assembly, measurement of the current supplied by the assembly, and determination of a ratio between measured current and reference current to deduce the proportion between the surface area of photosensitive element illuminated and the surface area masked by the objects disposed. From this ratio, information on the number of objects disposed on the photosensitive assembly is extracted.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: November 14, 2017
    Assignees: Commissariat A L'Energie Atomique et aux Energies Alternatives, Isorg
    Inventors: Josep Segura Puchades, Christophe Premont
  • Patent number: 9784961
    Abstract: Test kits for assessing male fertility include a sample holder defining an object plane, a lens, and a two dimensional light sensor defining an image plane arranged along a common linear axis. The distance between the object plane and the image plane may be no more than 50 mm, and may be no more than 30 mm. A lens aperture may have an area of 1-10 mm2. The test kit may have a housing with a maximum linear dimension of no more than 100 mm. Processing circuitry may be provided that is configured to produce a sperm count and/or sperm motility measurements by processing image data from the two-dimensional light sensor.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: October 10, 2017
    Assignee: Church & Dwight Co., Inc.
    Inventors: Nicholas James Wooder, Giles Sanders, Albert R. Nazareth, Shang Li
  • Patent number: 9782777
    Abstract: The invention concerns a v-bottomed sample plate, a frame for sample plates and a kit and method for processing biological samples. The kit comprises a tray assembly and a plurality of sample plates designed to fit into the tray assembly. The tray assembly comprises a frame having a central plate receiving portion having a width and length, whereby said tray assembly is capable of accommodating the sample plates side by side in the plate receiving portion. Each of the sample plates contains a plurality of individual sample wells arranged in a grid, the dimension of the plate in a first direction being at maximum the width of the frame and the dimension of the plate in a second direction being at maximum half of the length of the plate receiving portion of the of the frame, and means for enabling automated handling of the plates. The invention enables more efficient biomedical processing of samples.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: October 10, 2017
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Michael J. Mortillaro, Bruce R. Turner, David A. Cohen
  • Patent number: 9784683
    Abstract: A plasmonic sensor, having at least a substrate, a laser processed active surface area on the said substrate, and a metal coating on the activate surface, where the laser processed surface is fabricated by means of short laser pulses in such a way that in a shallow layer of the surface material, the viscosity is reduced and under the influence of the same pulse, which was used to reduce the viscosity, or a successive incident one or more pulses a self-organized, stochastic nanostructure is formed, which has features smaller than 1 ?m. In some implementations, the substrate material is amorphous, such as soda-lime glass or similar. Also disclosed is a slide and/or a slip cover, which are used in microscopy, for forming the active sensor area on top surface of it.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: October 10, 2017
    Assignee: ATO ID, UAB
    Inventors: Evaldas Pabreza, Gediminas Raciukaitis
  • Patent number: 9778275
    Abstract: A system for placing sample tubes into tube receptacles includes a sample handling device that includes an electrical signal, relating to an operating condition, such as a position error, a tube receptacle, and a processor configured to control the sample handling device in response to the electrical signal. The processor observes the operating condition for signal artifacts that indicate that a sample vessel being placed has encountered a holding spring and subsequently the bottom of the tube receptacle. The processor provides substantially real-time control of the motion of the sample handling device in response.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: October 3, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Colin Mellars
  • Patent number: 9778171
    Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 3, 2017
    Inventor: Gal Ingber
  • Patent number: 9767343
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 19, 2017
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi