Sample, Specimen, Or Standard Holder Or Support (e.g., Plates Or Slides) Patents (Class 356/244)
  • Patent number: 11402332
    Abstract: A surface enhanced luminescence (SEL) sensor may include a substrate and nano fingers extending from the substrate. In one implementation, the nano fingers may be arranged in a cluster of at least three nano fingers extending from the substrate. The nano fingers of the cluster having different geometries so as to bend into a closed state such that each of the nano fingers of the cluster are linked to one another.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: August 2, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Viktor Shkolnikov, Anita Rogacs, Steven J. Simske
  • Patent number: 11371093
    Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: June 28, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Dennis Lehto, Steven J. Boege
  • Patent number: 11337600
    Abstract: An endoscope (1) having a heating device (7) with at least one stiffened area (9, 10, 27) on a printed circuit board (8). At least one heating element (11) of the heating device is arranged in the stiffened area (9, 10, 27), and the heating device (7) is laid flat, from the outside, on a metallic head part (4) at the distal end (3) of the endoscope.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 24, 2022
    Assignee: SCHOLLY FIBEROPTIC GMBH
    Inventors: Dieter Schan, Tilman Stahle, Markus Bleiziffer
  • Patent number: 11334980
    Abstract: The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: May 17, 2022
    Assignee: bioMerieux, Inc.
    Inventors: Thierry Vivet, Dennis Connor, Mark Segrist, Mark S. Wilson, John G. Link
  • Patent number: 11326989
    Abstract: Devices and systems are provided herein relating to a novel and rapid assay for tissue staining. Methods for using the devices and systems for analyzing tissue samples are also disclosed.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 10, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Chou, Wei Ding, Ji Li
  • Patent number: 11311886
    Abstract: The invention relates to a holding apparatus (100) for sample carriers (200) for use in cryomicroscopy, encompassing: a body having at least one sample carrier receptacle that comprises at least one sample carrier support surface against which at least one sample carrier (200) is abuttable; at least one first sample carrier holding means (121); and at least one second sample carrier holding means (131) that is configured to impinge upon the sample carrier (200) with force against the first sample carrier holding means (121); and to an arrangement having a manipulation container and such a holding apparatus (100), and to methods for introducing and withdrawing a sample carrier (200).
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: April 26, 2022
    Assignee: LEICA MIKROSYSTEME GMBH
    Inventors: Reinhard Lihl, Leander Gaechter, Saskia Mimietz-Oeckler
  • Patent number: 11308640
    Abstract: A method of registering features in a repeating pattern can include (a) providing an object having a repeating pattern of features and a fiducial; (b) obtaining a target image of the object, wherein the target image includes the repeating pattern of features and the fiducial; (c) comparing the fiducial in the target image to reference data, wherein the reference data includes xy coordinates for a virtual fiducial; and (d) determining locations for the features in the target image based on the comparison of the virtual fiducial in the reference data to the fiducial in the data from the target image. The fiducial can have at least concentric circles that produce three different signal levels. The locations of the features can be determined at a variance of less than 5 ?m.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 19, 2022
    Assignee: ILLUMINA, INC.
    Inventors: John S. Vieceli, Stephen Tanner, John A. Moon, M. Shane Bowen
  • Patent number: 11300518
    Abstract: A method for determining the degree of polymerization of a polymer is disclosed, the polymer being contained in a sample (2), the method comprising the following steps: a) illuminating the sample (2) using a laser beam (11) and acquiring (100) a Raman spectrum (S) representative of the polymer; b) identifying (110) a peak of interest (Pi) and determining (120) a position (vi) of the peak of interest in the Raman spectrum; c) on the basis of the position of the peak of interest, using a calibration function (ƒ) to determine a degree of polymerization (DP, DE) of the polymer, the calibration function expressing a variation in the position of the peak of interest as a function of the degree of polymerization of the polymer.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 12, 2022
    Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, ROQUETTE FRERES
    Inventors: Emeric Bergmann, Jean-Charles Baritaux, Baptiste Boit, Aline Lecocq, Veronique Rebuffel, Oumar Toure, Mathias Ibert
  • Patent number: 11287388
    Abstract: A method for inspecting a semiconductor element includes steps of: a) providing an inspection apparatus including a supporting unit that includes a central seat and a plurality of positioning plates, and a camera unit that includes a first image capture device; b) positioning the semiconductor element onto the positioning plates; c) capturing a first bottom image of the semiconductor element; d) generating relative movement between the semiconductor element and the positioning plates; e) capturing a second bottom image of the semiconductor element; and f) synthesizing the first bottom image and the second bottom image to obtain a complete bottom image of the semiconductor element.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: March 29, 2022
    Assignee: V5 TECHNOLOGIES CO., LTD.
    Inventors: Kuo-Ming Tseng, Yueh-Heng Lee
  • Patent number: 11282684
    Abstract: The present invention relates to a method for producing test pieces in which the thickness of the samples of homogeneous water-insoluble material is uniform, and to a method for quantitative analysis of water-insoluble material by analyzing such test pieces using MALDI mass spectrometry. Specifically, the test pieces can be produced by: adding a volatile solvent to a mixture of water-insoluble material and matrix; placing, in a pellet cup made of water-soluble material, and pressing, with even pressure, the sample obtained by mixing the mixture of water-insoluble material and matrix until the solvent has evaporated; and melting the pellet cup with water.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: March 22, 2022
    Inventors: Yongjin Bae, Young Hee Lim, Yeu Young Youn, Joo Eun Jung, Byung Hyun Park, Hyun Sik You
  • Patent number: 11262349
    Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: March 1, 2022
    Assignee: Cleveland State University
    Inventors: Moo-Yeal Lee, Xue-Long Sun
  • Patent number: 11253852
    Abstract: This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: February 22, 2022
    Assignee: Abbott Point of Care Inc.
    Inventors: Michael Louie Low, Barry Bass, Sergey Gershtein
  • Patent number: 11169061
    Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: November 9, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
  • Patent number: 11156606
    Abstract: Among other things, the present disclosure is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly a homogeneous assay that does not use a wash step and that is fast (e.g., 60 seconds from dropping a sample to displaying results). The present disclosure is related to both competitive and non-competitive homogeneous assays.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 26, 2021
    Assignee: Essenlix Corporation
    Inventors: Stephen Chou, Wei Ding, Ji Li, Yufan Zhang
  • Patent number: 11141725
    Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 12, 2021
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Garland Christian Misener, Richard Ellis Holt, Keith Nassif
  • Patent number: 11112359
    Abstract: A target substance detection device detecting a target substance using magnetic particles includes a detection chip, a light irradiation unit, and a magnetic field application unit, wherein the detection chip includes a light transmissive member having a sensing surface arranged on a surface constituting a top surface relative to a bottom surface, an inclined surface, and a main body portion capable of receiving light and guiding the light through the interior, the light transmissive member having a light directing structure in which the light applied from the top surface side and passed through the inclined surface is directed via the main body portion to the sensing surface under the condition of total reflection, the light irradiation unit is operable to irradiate the sensing surface with light under the condition of total reflection via the light directing structure, and the magnetic field application unit.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: September 7, 2021
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOPPAN PRINTING CO., LTD.
    Inventors: Makoto Fujimaki, Hiroki Ashiba, Masato Yasuura, Shu Tanabe, Susumu Takahashi
  • Patent number: 11079327
    Abstract: An optical sensor has a body including a transparent interface wall having an outer surface in contact with a liquid, to define therewith a reflection interface. An optical module is coupled at an inner surface of the interface wall, to detect a characteristic of the liquid substance via light reflection. The optical module includes a light emitter and a light receiver facing respective inclined surfaces of the interface wall. The optical module also includes a supporting structure which is elastically flexible, to enable the light emitter and the light receiver of the optical module to vary a relative position thereof and with respect to the inclined surfaces of the interface wall, when the supporting structure is secured to the inner surface of the interface wall.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: August 3, 2021
    Assignee: ELTEK S.p.A.
    Inventors: Marco Pizzi, Piercarlo Merlano, Fabio Cavalli, Mauro Zorzetto
  • Patent number: 11080248
    Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: August 3, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi, Tarun Khurana
  • Patent number: 11073478
    Abstract: A device and method for determining substances within a fluid stream through the employment of light projected therethrough or emitted by the substances energized in the fluid stream. The device features a fluid chamber through which light, at known wavelengths, is projected through the fluid stream to a light sensor. The substances in the fluid stream are determinable by ascertaining which respective light wavelengths emitted by the light emitter do not contact the light sensor because they are absorbed by respective substances in the fluid stream. Alternatively, the substances in the fluid stream can be energized to emit light in wavelengths which can be ascertained as emitted by individual substances.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: July 27, 2021
    Inventor: Brenton Ferguson
  • Patent number: 11054346
    Abstract: This disclosure is directed to a system and method for detecting a surface of a substrate within a scanner.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: July 6, 2021
    Assignee: RareCyte, Inc.
    Inventors: Paulina Varshavskaya, Edward Shafer, Steve Quarre, Ronald Seubert
  • Patent number: 11054364
    Abstract: A system comprises: (a) a robotic arm; (b) a needle capillary coupled to the robotic arm; (c) a cell coupled to the robotic arm comprising: a housing; first and second windows disposed within the housing and defining a width of an internal chamber therebetween; a collimating lens optically coupled to the first window; a focusing lens optically coupled to the second window; an inlet port fluidically coupled to a first end of the internal chamber; and an outlet port fluidically coupled to a second end of the internal chamber; (d) a pump; (e) first and second tubings fluidically coupled, respectively, between the needle capillary and the inlet port and between the pump and the outlet port; (f) a light source; (g) a photodetector; and (h) first and second optical fibers optically coupled, respectively, between the light source and the collimating lens and between the photodetector and the focusing lens.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: July 6, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventors: Greg A. Foster, Daniel Lopez Ferrer
  • Patent number: 11047857
    Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: June 29, 2021
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Eugene Chan, Keith Nassif
  • Patent number: 11047796
    Abstract: A sampling tool for use with an infrared spectrophotometer, and method of use. The sampling tool comprises a bottom plate; and a mesh attached to the bottom plate, the mesh having a plurality of interstitial spaces, and the mesh having a mesh width and a mesh thickness, wherein the mesh is configured to receive a sample material and retain a portion of the sample material within the interstitial spaces of the mesh to form a sample having a sample thickness which is substantially the same as the mesh thickness. The mesh width may be sized to be in a range of about 1 to 3 times the width of an infrared beam directed toward the sampling tool from the spectrophotometer.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: June 29, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Robert L. White
  • Patent number: 11035868
    Abstract: Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. In some embodiments, the system can include, for example, a slide ejector assembly having a slide staging device configured to receive a slide and an over-travel inhibitor that includes a first vacuum port positioned to draw a first vacuum between the slide and a standby platform as the slide is moved across at least a portion of the standby platform. The over-travel inhibitor includes a first sensor for detecting a presence of the slide on the standby platform. The system can also include a transfer assembly to transport slides away from the slide ejector assembly. The transfer assembly can include a floating transfer head having a vacuum port for drawing a partial vacuum for holding the slide.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: June 15, 2021
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Timothy James Durrant, Joshua David Kenneth Harrison, Benjamin Arthur James, Matthew Ketterer, John Douglas Willems
  • Patent number: 11022621
    Abstract: An image acquisition system includes a cassette mounting unit that holds slide glasses in a plurality of stages, a cassette having an identification code imparted thereto being mounted in the cassette mounting unit, an identification code reading unit that reads an identification code from the cassette, an image acquisition unit that acquires image data of a sample held on the slide glass, and a control computer that associates the image data with cassette identification information included in the identification code read by the identification code reading unit, wherein the cassette mounting unit includes a notch portion that exposes a bar code imparted to the cassette, and the identification code reading unit includes an imaging unit that images the identification code exposed from the notch portion in a reading position.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: June 1, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventor: Yuichi Toyoda
  • Patent number: 10988722
    Abstract: The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 27, 2021
    Assignee: EMULATE, Inc.
    Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy, Joshua Gomes, Norman Wen, Jacob Freake, Doug Sabin
  • Patent number: 10988721
    Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: April 27, 2021
    Assignee: EMULATE, Inc.
    Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
  • Patent number: 10969340
    Abstract: A heating chamber (1) for a heating furnace is proposed, with which electrothermal vaporization of impurities from samples can be effected in order to be able to then analyze them spectrometrically. The heating chamber has a wall (3), a sample reception area (5), a nozzle area (7) and two electrical connection areas (9, 11). The heating chamber (1) is specially configured such that an electric current flows through the wall (3) in such a way that a heating capacity caused by it is higher in the nozzle area (7) than in the sample reception area (5).
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: April 6, 2021
    Assignee: SCHUNK KOHLENSTOFFTECHNIK GMBH
    Inventors: Joachim Metz, Ralf Gärtner, Simon Hintner
  • Patent number: 10962511
    Abstract: Systems are provided for a modular multi-wavelength UV-VIS detector unit, such as an absorbance detector (e.g., spectrophotometer) included in a high-performance liquid chromatography system. In one example, a detector unit includes one or more light emitters and a sliding assembly configured to slidingly move a flow cell relative to the one or more light emitters, the one or more light emitters mounted on a floating rig to facilitate alignment between the one or more light emitters and the flow cell when the sliding assembly is in a closed position.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: March 30, 2021
    Assignee: Phoseon Technology, Inc.
    Inventors: John Christopher Freitag, Shiou-jyh Ja, Brad Scardino, Randy James
  • Patent number: 10948402
    Abstract: A glass vial illumination and inspection system may be provided with a light source and a stand. The stand may have an internal cavity configured to receive at least a portion of the light source. A recess may be located in the stand and configured to receive at least a portion of a glass vial. The stand may be configured to aim the light output from the light source toward the glass vial to illuminate the vial. The stand may be configured to position the vial such that an inspector can manually inspect the illuminated vial for defects. Methods of use are also disclosed.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: March 16, 2021
    Assignee: Genentech, Inc.
    Inventors: Nicholas Coles, Makayla Gessford, Andrew David Norriss, Mitsutaka Shirasaki
  • Patent number: 10942347
    Abstract: A fixed reference edge system that guides a glass slide from a slot of a slide rack onto a scanning stage and guides the glass slide from the scanning stage into the slot of the slide rack. In an embodiment, the fixed reference edge has a first side that is parallel to a side of the slot of the slide rack. The system comprises an assembly that includes a push bar configured to push the slide from the slot onto the scanning stage, and a pull bar configured to pull the slide from the scanning stage into the slot of the slide rack. When the slide is pulled into the slide rack, the long edge of the slide is pressed against the first side of the fixed reference edge to maintain a parallel orientation between the slide and the slot of the slide rack.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: March 9, 2021
    Assignee: LEICA BIOSYSTEMS IMAGING, INC.
    Inventor: Nicholas Newberg
  • Patent number: 10935490
    Abstract: A nephelometer that measures turbidity of low volume suspensions using measurements of light transmitted through and/or scattered by the sample. The sample suspension is placed in a tiered cuvette adapted to facilitate measuring the turbidity of low volume samples. The lower portion of the cuvette has smaller dimensions, in horizontal cross section, than the top portion. Both lower and upper portions have angled surfaces. The lower, smaller portion of the cuvette is interrogated by the nephelometer.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: March 2, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Brian Reuben Langhoff, William Alan Fox, Kerry Lynn Smith
  • Patent number: 10928621
    Abstract: Disclosed herein are sample dishes for use with microscopes that are simple to mount on a microscope and facilitate easy manipulation of tissue samples disposed thereon during imaging as well as methods of their use. A sample dish comprises an optical interface and, optionally, a support member that holds the optical interface. The optical interface of a sample dish is suitably transparent and planar such that a focal plane of a microscope can reside uniformly at or within a surface of a sample during imaging. In certain embodiments, a support member comprises a dish for holding excess fluid. In certain embodiments, a sample dish comprises separation ribs. In certain embodiments, a sample dish comprises one or more manipulation members (e.g., tabs). In certain embodiments, a sample dish is used with an imaging artifact reducing fluid.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: February 23, 2021
    Assignee: SamanTree Medical SA
    Inventors: Etienne Shaffer, Jonathan Abel Pirolet, Frédéric Schmitt, Bastien Rachet, Diego Joss, Aurèle Timothée Horisberger
  • Patent number: 10913924
    Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: February 9, 2021
    Assignee: Emulate, Inc.
    Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
  • Patent number: 10872743
    Abstract: Continuous and automatic acquisition of electron beam holograms is made possible by using a sample holding mechanism that includes a sample end region that has a linear shape that is suited for electron beam holography, separates a thin-film rectangular window with an extreme-thin support film that supports a sample being disposed and a rectangular hole that has a linear-shaped edge and through which a reference wave is transmitted from each other, and configures a part of a layer that is thicker than the support film.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: December 22, 2020
    Assignee: HITACHI, LTD.
    Inventors: Akira Sugawara, Yoshio Takahashi, Tetsuya Akashi, Toshiaki Tanigaki
  • Patent number: 10850397
    Abstract: An actuation system to manipulate an interface in an aircraft having an actuation controller, a vision system, a robotic arm, and a housing. Each of the vision system and the robotic arm assembly may be operatively coupled to the actuation controller. The vision system may be configured to optically image a display device of the preexisting interface, while the robotic arm assembly may be configured to engage a user-actuable device of the preexisting interface. The housing can be configured to affix to a surface adjacent the preexisting interface, where each of the vision system and the robotic arm assembly are coupled to the housing. In operation, the actuation controller may be configured to instruct the robotic arm assembly based at least in part on data from the vision system.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 1, 2020
    Assignee: Aurora Flight Sciences Corporation
    Inventors: William Bosworth, James D. Paduano
  • Patent number: 10844342
    Abstract: Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a slide carrier comprising a plurality of compartment walls that define compartments for holding embryo slides within the incubation chamber for incubation. The slide carrier is moveable, for example by rotation, relative to the incubation chamber housing to allow a selected compartment to be moved to a loading position defined at least in part by a loading port wall associated with the incubation chamber housing. The loading port wall is arranged to cooperate with the wall of a compartment in the loading position to restrict the extent to which the environment of the compartment in the loading position is in fluid communication with the environments of other compartments in the incubation chamber.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: November 24, 2020
    Assignee: UNISENSE FERTILITECH A/S
    Inventors: Niels Ramsing, Kim Bondergaard Madsen, Jonas Lerche Hansen, Troels Kofoed Mejer, Jorgen Berntsen
  • Patent number: 10816788
    Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: October 27, 2020
    Assignee: SamanTree Medical SA
    Inventors: Etienne Shaffer, Bastien Rachet, Aurèle Timothée Horisberger, Jonathan Abel Pirolet, Diego Joss, Frédéric Schmitt
  • Patent number: 10816562
    Abstract: A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: October 27, 2020
    Assignee: LEICA BIOSYSTEMS IMAGING, INC.
    Inventors: Nicholas Newberg, Prentash Djelosevic, Aaron Stearrett, Peyman Najmabadi
  • Patent number: 10809195
    Abstract: A sensor platform (300) with a sensor surface (350) receives particles (400). A material extending from the sensor surface (350) having a refractive index higher than the one of the fluid (200), such that an electromagnetic wave (10) propagating in this platform material (310) and incident to the sensor surface (350) at an angle greater than the critical optical angle is totally reflected onto the sensor surface (350). The particles (400) suspended in the fluid (200) include a metallic material (410) enabling a localized surface plasmon resonance at resonant wavelength(s). An optical detector (102) detects a portion of a spectrum of the totally reflected wave (20), including the resonant wavelength(s). A processor determines a presence of the particles (400) on or close to the sensor surface (350) from a frustrated totally internal reflection (“FTIR”) signal retrieved from the detected wavelengths. The retrieving takes into account the detected resonant component(s) present in the FTIR signal.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: October 20, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Ganeshram Krishnamoorthy, Joukje Garrelina Orsel, Johannes Joseph Hubertina Barbara Schleipen
  • Patent number: 10794917
    Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in appendicitis patients and in patients at risk for appendicitis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: October 6, 2020
    Assignee: Astute Medical, Inc.
    Inventors: Joseph Anderberg, Jeff Gray, Paul McPherson, Kevin Nakamura, James Patrick Kampf, Thomas Kwan
  • Patent number: 10730071
    Abstract: A method for producing a plurality of measurement regions on a chip, and a chip having a plurality of measurement regions which is obtainable by the method.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 4, 2020
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Axel Niemeyer, Heinz-Ulrich Schoeder, Matthias Griessner
  • Patent number: 10732122
    Abstract: A system for biological sample analysis includes a plurality of modular subassemblies and a precision mounting plate, wherein each modular subassembly includes an enclosure and a plurality of optical components pre-aligned to the enclosure, and the enclosure includes a plurality of precision mounting structures, and each modular subassembly is mechanically coupled to the precision mounting plate, such that each precision mounting structure from a modular subassembly attaches directly to a corresponding precision mounting structure located on the precision mounting plate or an adjacent modular subassembly to optimize optomechanical tolerance.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 4, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
  • Patent number: 10732104
    Abstract: Provided is a measuring chip, a measuring device and a measuring method, which are capable of performing a more simple and highly accurate measurement than the conventional measurement. Light introduced into an incoming part may propagate while totally reflecting within a propagating part of a propagation layer. A phase shift amount in the total internal reflection may be different between sections of an upper surface of the propagation layer where a ligand is formed and where a ligand is not formed. When an analyte is adsorbed to the ligand, the phase shift amount in the reflection may become larger than before attaching the analyte. As a result, a beam pattern of the light outputted from an outgoing part may change.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: August 4, 2020
    Assignee: FURUNO ELECTRIC CO., LTD.
    Inventors: Keiji Tada, Jun Yamabayashi
  • Patent number: 10723145
    Abstract: A curing chamber for curing and drying a flat printing product printed with at least one UV-curing pigment comprising a first chamber wall which comprises a cooling surface or is a cooling surface, a second chamber wall which is opposite the first chamber wall, wherein at least one UV lamp directed onto the cooling surface is arranged on or in the second chamber wall, third and fourth chamber walls which are arranged opposite one another between the first and the second chamber walls and which each comprise an introductory slot or removal slot and/or form an appropriate slot to the first chamber wall, fifth and sixth side walls arranged opposite one another and arranged between the first and the second chamber walls, wherein a gas inlet or a gas outlet is arranged in the vicinity of the third and fourth chamber walls, and the gas inlet is an inert gas inlet.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 28, 2020
    Assignee: HAPA AG
    Inventors: Migjen Rrahimi, Nicole Howald, Matthias Theiler, Marcel Holdener, Stefan Braun, René Colombo, Sascha Simon
  • Patent number: 10718748
    Abstract: An apparatus may have a first reflector and a second reflector positioned on either side of a sample volume for a gas sample. The configuration of the first reflector may be variable between at least first and second configurations, wherein each of the first and second configurations is arranged such that a beam of optical radiation from an optical beam origin is directed to a detector location via the sample volume. In the second configuration the beam of optical radiation is reflected at least once from each of the first and second reflectors and the path length of the beam of optical radiation through the sample volume is greater than in the first configuration.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 21, 2020
    Assignee: General Electric Technology GmbH
    Inventor: David Peter Robinson
  • Patent number: 10704016
    Abstract: Disclosed are devices for propagating at least one microtissue, methods for manufacturing such devices, and the use us such devices, said devices comprise at least one well, wherein said at least one well comprises an open upper section comprising an open upper end and an open lower end, and a lower section comprising an open upper end and a bottom end, wherein the upper section and the lower section are in fluid communication, and wherein the bottom end of the lower section of at least one well of said plurality of wells is provided with a well bottom, said lower section of said at least one well has a smaller cross-sectional area than the open upper section of the same well.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 7, 2020
    Assignee: INSPHERO AG
    Inventors: Jan Lichtenberg, Wolfgang Moritz, Jens Kelm
  • Patent number: 10689608
    Abstract: Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: June 23, 2020
    Assignee: EMULATE, INC.
    Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy
  • Patent number: 10663711
    Abstract: Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: May 26, 2020
    Assignee: Corista, LLC
    Inventors: Eric W. Wirch, David C. Wilbur, Richard Y. Wingard, II, Michael Ryan Tomer, Kevin Christopher Dorosh, Jonathan Mitchell Gaines, Odell Christian Dotson, Aristana Olivia Scourtas
  • Patent number: 10663378
    Abstract: Tissue samples embedded in settable, sectionable media such as paraffin can be cut into sections. Embedding one or more sectionable fiducial indicia in the medium permits identification of the plane along which the medium has been cut. However, prior methods of inserting indicia into embedded tissue sample blocks are cumbersome and difficult to perform. Sectionable fiducial indicia can be embedded in a block of medium by releasibly fixing the indicia to the sidewall or base of a mold used to shape the tissue block during embedding of a tissue sample in the medium block.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 26, 2020
    Assignee: Rowan University
    Inventor: Vince Beachley