Sample, Specimen, Or Standard Holder Or Support (e.g., Plates Or Slides) Patents (Class 356/244)
  • Patent number: 10732122
    Abstract: A system for biological sample analysis includes a plurality of modular subassemblies and a precision mounting plate, wherein each modular subassembly includes an enclosure and a plurality of optical components pre-aligned to the enclosure, and the enclosure includes a plurality of precision mounting structures, and each modular subassembly is mechanically coupled to the precision mounting plate, such that each precision mounting structure from a modular subassembly attaches directly to a corresponding precision mounting structure located on the precision mounting plate or an adjacent modular subassembly to optimize optomechanical tolerance.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 4, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
  • Patent number: 10730071
    Abstract: A method for producing a plurality of measurement regions on a chip, and a chip having a plurality of measurement regions which is obtainable by the method.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 4, 2020
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Axel Niemeyer, Heinz-Ulrich Schoeder, Matthias Griessner
  • Patent number: 10732104
    Abstract: Provided is a measuring chip, a measuring device and a measuring method, which are capable of performing a more simple and highly accurate measurement than the conventional measurement. Light introduced into an incoming part may propagate while totally reflecting within a propagating part of a propagation layer. A phase shift amount in the total internal reflection may be different between sections of an upper surface of the propagation layer where a ligand is formed and where a ligand is not formed. When an analyte is adsorbed to the ligand, the phase shift amount in the reflection may become larger than before attaching the analyte. As a result, a beam pattern of the light outputted from an outgoing part may change.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: August 4, 2020
    Assignee: FURUNO ELECTRIC CO., LTD.
    Inventors: Keiji Tada, Jun Yamabayashi
  • Patent number: 10723145
    Abstract: A curing chamber for curing and drying a flat printing product printed with at least one UV-curing pigment comprising a first chamber wall which comprises a cooling surface or is a cooling surface, a second chamber wall which is opposite the first chamber wall, wherein at least one UV lamp directed onto the cooling surface is arranged on or in the second chamber wall, third and fourth chamber walls which are arranged opposite one another between the first and the second chamber walls and which each comprise an introductory slot or removal slot and/or form an appropriate slot to the first chamber wall, fifth and sixth side walls arranged opposite one another and arranged between the first and the second chamber walls, wherein a gas inlet or a gas outlet is arranged in the vicinity of the third and fourth chamber walls, and the gas inlet is an inert gas inlet.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 28, 2020
    Assignee: HAPA AG
    Inventors: Migjen Rrahimi, Nicole Howald, Matthias Theiler, Marcel Holdener, Stefan Braun, René Colombo, Sascha Simon
  • Patent number: 10718748
    Abstract: An apparatus may have a first reflector and a second reflector positioned on either side of a sample volume for a gas sample. The configuration of the first reflector may be variable between at least first and second configurations, wherein each of the first and second configurations is arranged such that a beam of optical radiation from an optical beam origin is directed to a detector location via the sample volume. In the second configuration the beam of optical radiation is reflected at least once from each of the first and second reflectors and the path length of the beam of optical radiation through the sample volume is greater than in the first configuration.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 21, 2020
    Assignee: General Electric Technology GmbH
    Inventor: David Peter Robinson
  • Patent number: 10704016
    Abstract: Disclosed are devices for propagating at least one microtissue, methods for manufacturing such devices, and the use us such devices, said devices comprise at least one well, wherein said at least one well comprises an open upper section comprising an open upper end and an open lower end, and a lower section comprising an open upper end and a bottom end, wherein the upper section and the lower section are in fluid communication, and wherein the bottom end of the lower section of at least one well of said plurality of wells is provided with a well bottom, said lower section of said at least one well has a smaller cross-sectional area than the open upper section of the same well.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 7, 2020
    Assignee: INSPHERO AG
    Inventors: Jan Lichtenberg, Wolfgang Moritz, Jens Kelm
  • Patent number: 10689608
    Abstract: Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: June 23, 2020
    Assignee: EMULATE, INC.
    Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy
  • Patent number: 10663378
    Abstract: Tissue samples embedded in settable, sectionable media such as paraffin can be cut into sections. Embedding one or more sectionable fiducial indicia in the medium permits identification of the plane along which the medium has been cut. However, prior methods of inserting indicia into embedded tissue sample blocks are cumbersome and difficult to perform. Sectionable fiducial indicia can be embedded in a block of medium by releasibly fixing the indicia to the sidewall or base of a mold used to shape the tissue block during embedding of a tissue sample in the medium block.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 26, 2020
    Assignee: Rowan University
    Inventor: Vince Beachley
  • Patent number: 10663711
    Abstract: Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: May 26, 2020
    Assignee: Corista, LLC
    Inventors: Eric W. Wirch, David C. Wilbur, Richard Y. Wingard, II, Michael Ryan Tomer, Kevin Christopher Dorosh, Jonathan Mitchell Gaines, Odell Christian Dotson, Aristana Olivia Scourtas
  • Patent number: 10649195
    Abstract: A confocal slide-digitizing apparatus (100) includes a slide handling unit (20) and an imaging unit (10), wherein the slide handling unit (20) has a slide supplier unit (90). The imaging unit (10) has a light source (40) to illuminate the sample to be digitized at the imaging position through an objective (18) arranged in a light path that enables confocal imaging of at least a region of the sample and an image recording unit to receive light with information on at least an illuminated region of the sample through the objective (18) and generate a digital image of a section of a given thickness of said illuminated region. Moreover, said slide handling unit (20) and said imaging unit (10) are joined mechanically together in a tiltable manner relative to one another, thereby correcting the light path of said confocal imaging.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 12, 2020
    Assignee: 3DHISTECH KFT.
    Inventors: Viktor Sebestyén Varga, Béla Molnár, Gergely Kovách, Dániel Luczi
  • Patent number: 10605677
    Abstract: A method for calibrating thermal analysis device includes: photothermal measurements on a sample consecutively held in the plurality of sample holders, or on a plurality of similar samples, which are in each case held in one of the plurality of sample holders, wherein a first side of the respective sample is irradiated with an electromagnetic excitation pulse and a thermal radiation emitted by a second side of this sample is captured; comparing results of the photothermal measurements for the plurality of sample holders; in each case determining at least one correction parameter for each sample holder based on a result of the comparison; and calibrating the temperature measuring system of the device and/or the temperature control systems of the device based on the determined correction parameters.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: March 31, 2020
    Assignee: Netzsch-Gerätebau GmbH
    Inventors: Martin Brunner, André Lindemann
  • Patent number: 10591709
    Abstract: A cell imaging apparatus captures images of cells contained in a liquid specimen comprising: an image capture unit including an objective lens, specimen cells each including an inner space which is capable of holding a liquid specimen and which is elongated in one direction, the specimen cells arranged such that the inner spaces are aligned in a row in a longitudinal direction of the inner spaces, a drive unit that moves at least one of: a) one or more specimen cells; and b) the objective lens; and a controller that controls the drive unit to move at least one of: a) one or more specimen cells; and b) the objective lens in the longitudinal direction and controls the image capture unit to capture images of cells contained in a liquid specimen held in the inner space of each of the specimen cells at multiple image capture positions.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: March 17, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Masakazu Fukuda, Yanyan Liu, Toshihiro Ootani
  • Patent number: 10585084
    Abstract: A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: March 10, 2020
    Inventors: Joshua D. Levine, Robert A. Levine, Stephen C. Wardlaw, Craig Stout, David A. Clipper
  • Patent number: 10585001
    Abstract: There is disclosed a sample holder comprising: a base member; a holder member attached to the base member, the holder member having at least one flexible tab resiliently biased towards the base member; wherein one of the base member and the tab comprises a first formation provided on a face thereof so that a sample having a corresponding second formation can be located between the tab and the base member and retained by cooperation of the first and second formations.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: March 10, 2020
    Assignee: WGSN LIMITED
    Inventor: Eric Schäfer
  • Patent number: 10570435
    Abstract: The present invention relates to a cell determination method for determining a cell type based on a content of glycogen in a cell, including: an acquisition step of acquiring optical path length data by measuring an optical path length of the cell; a calculation step of calculating an optical path length indicator correlated with the optical path length of the cell from the obtained optical path length data; a comparison step of comparing the calculated optical path length indicator with a threshold; and a determination step of determining whether the cell is a cell type having a high glycogen content in the cell or a cell type having a low glycogen content in the cell, based on the comparison result.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: February 25, 2020
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Tadashi Fukami, Hidenao Yamada
  • Patent number: 10552965
    Abstract: The atomic absorption spectrophotometer is provided with an atomization unit, a light source, a detector, an optical system, a camera, and a captured image data storage unit. The atomization unit has a tube-like furnace and atomizes the sample injected into the furnace by heating the sample. The light source emits light of a wavelength of a measurement target toward the atomization unit so that the light passes through the furnace. The detector detects the light passed through the furnace. The camera captures an image of an inside of the furnace before performing a measurement process in which a sample is atomized in the furnace and its absorbance is measured. The captured image data storage unit stores the captured image data obtained by capturing the image by the camera in association with the measurement data corresponding to the captured image data.
    Type: Grant
    Filed: November 24, 2018
    Date of Patent: February 4, 2020
    Assignee: Shimadzu Corporation
    Inventor: Osuke Kobayashi
  • Patent number: 10545162
    Abstract: A method for aligning a reaction ring in an analyzer system using a gauge vertical reaction ring comprising at least one end slot includes inserting a light beam gauge into an aperture operable to hold the light beam gauge at a height corresponding to a photometer included in the analyzer system. The gauge vertical reaction ring is rotated on the reaction ring until the light beam gauge engages the end slot to confirm alignment of the reaction ring with the photometer.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: January 28, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Donald Phillips, Tan Bui
  • Patent number: 10539776
    Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 21, 2020
    Assignee: SamanTree Medical SA
    Inventors: Etienne Shaffer, Bastien Rachet, Aurèle Timothée Horisberger, Jonathan Abel Pirolet, Diego Joss
  • Patent number: 10519410
    Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 31, 2019
    Assignee: Emulate, Inc
    Inventors: Christopher David Hinojosa, Guy Robert Thompson, II, Joshua Gomes, Jacob Freake, Doug Sabin
  • Patent number: 10509216
    Abstract: A specimen processing system is capable of processing specimens carried on slides. The specimen processing system can sequentially deliver slides and opposables to specimen processing stations. The specimen processing stations can use the opposables to apply a series of liquids to the specimens. The applied liquid can be moved along the slide using capillary action while the specimen processing stations control the processing temperatures.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: December 17, 2019
    Assignee: VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Brian Kram, Sacha Dopheide, Jessica Wifall, Kevin Marshall, Simon Spence, Andrew Watkins, Austin Ashby, Bryan Barnes, Henning Groll, Lizhen Pang, Patrick Brown, Mirek Holubec, Matthew Ketterer, Kevin Talucci, Benjamin James
  • Patent number: 10451480
    Abstract: Disclosed is a combination of a Fabry-Perot Tunable Filter (FPTF) wavelength selector, an internal reflection element (IRE) capable of measuring Attenuated Total Reflectance (ATR) spectra, and a pressure application element for applying pressure to samples, if needed. The resultant portable and compact device is called an FPTF-ATR spectrometer. The device measures data that can be used to identify chemical species in samples, predict properties of samples, and quantify amounts of chemical species in samples. Also disclosed are methods for using the FPTF-ATR for analyzing samples, especially analyzing compounds containing cannabis, hops, and other chemical species where portable chemical analysis is important.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: October 22, 2019
    Assignee: Big Sur Scientific, LLC
    Inventor: Brian Charles Smith
  • Patent number: 10421081
    Abstract: Technologies pertaining to a centrifuge that comprises a vector-seeking linkage are disclosed herein. In a general embodiment, the centrifuge comprises a spindle that is rotatable about an axis of rotation. The centrifuge also has an arm that is coupled to the spindle, and a vector-seeking linkage that is coupled to the arm. The vector-seeking linkage provides two rotational degrees of freedom with respect to a load coupled to the vector-seeking linkage. The centrifuge is well-suited for a variety of applications, including sensor testing, solution separation, and producing accelerations expected to be experienced during flight.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: September 24, 2019
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventor: Michael N. Rector
  • Patent number: 10408789
    Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: September 10, 2019
    Assignee: PRINCETON BIOCHEMICALS, INC.
    Inventor: Norberto A. Guzman
  • Patent number: 10391487
    Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: August 27, 2019
    Assignee: Abbott Point of Care, Inc.
    Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
  • Patent number: 10345548
    Abstract: The disclosure provides an optical apparatus including at least one optical element including glass, at least one support including silicon and a housing including glass. Furthermore, the at least one optical element and the at least one support can be anodically bonded together, and the at least one support and the housing can be anodically bonded together. The disclosure further provides a method for fabricating optical components with durable bonds and incorporates active alignment.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: July 9, 2019
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Nezih Dural, Michael V Romalis
  • Patent number: 10330601
    Abstract: The disclosure relates to a method for detecting single molecules on an object. The method includes: providing a carrier; attaching the carrier on a surface of the object so that the surface of the object is indirect contact with the carrier; and detecting the single molecules on the object with a detector. The carrier includes a flexible substrate and a metal layer on the flexible substrate. The flexible substrate includes a base and a bulge pattern located on a surface of the base. The bulge pattern includes a number of strip-shaped bulges intersecting with each other to form a net and define a number of recesses. The metal layer is located on the bulge pattern. The carrier has a relative higher SERS and can enhance the Raman scattering.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: June 25, 2019
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ying-Cheng Wang, Yuan-Hao Jin, Qun-Qing Li, Shou-Shan Fan
  • Patent number: 10302412
    Abstract: An apparatus includes a lighting unit configured to irradiate a light emitting device package including a light transmitting resin containing a light conversion material with light having a certain color; a camera configured to capture an image of the light emitting device package; and a controller configured to determine color coordinates of the light emitting device package using the image, captured by the camera, to determine whether the light emitting device package is defective.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: May 28, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Young Hyo Eun, Ju Hyun Song, Jae Sung Kim, Tae Hee Song, Shin Min Rhee
  • Patent number: 10295822
    Abstract: A method for producing a contrast-amplifying support comprising an absorbing substrate carrying at least one absorbing layer comprises a design step for the support and the following steps: i) choosing an illumination wavelength ?; ii) choosing a material constituting the substrate and exhibiting, at illumination wavelength ?, a complex refractive index N0=n0?jk0 with k0?0.01; iii) choosing an ambient medium in contact with the layer on the side opposite to the substrate and exhibiting, at illumination wavelength ?, a complex refractive index N3=n3?jk3 with k3?0; iv) determining a nominal complex refractive index N1=n1?jk1 and a nominal thickness e1 of the layer wherein it behaves in the guize of antireflection layer when illuminated under normal incidence at illumination wavelength ?; and v) choosing a material constituting the layer and exhibiting, at illumination wavelength ?, a complex refractive index whose real and imaginary parts coincide with the nominal complex refractive index.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 21, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DU MAINE
    Inventors: Dominique Ausserre, Claude Amra, Myriam Zerrad, Refahi Abou Khachfe
  • Patent number: 10281365
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: May 7, 2019
    Assignee: Aquaro Histology, Inc.
    Inventors: Collin Rich, Nolan Orfield, Vincent Alessi
  • Patent number: 10268031
    Abstract: The present invention relates to digital pathology. In order provide enhanced use of available imaging radiation, a digital pathology scanner (10) is provided that comprises a radiation arrangement (12), a sample receiving device (14), an optics arrangement (16), and a sensor unit (18). The radiation arrangement comprises a source (20) that provides electromagnetic radiation (22) for radiating a sample received by the sample receiving device. Further, the optics arrangement comprises at least one of the group of a lens (24) and a filter (26) that are arranged between the sample receiving device and the sensor unit. The sensor unit is configured to provide image data of the radiated sample. Still further, a lens array arrangement (28) is provided that comprises at least one lens array (30) arranged between the source and the sample receiving device.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 23, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Marius Iosif Boamfa, Reinhold Wimberger-Friedl, Theodoor Bastiaan Johannes Haddeman
  • Patent number: 10247743
    Abstract: The type of blood collection tube (1) inserted into this system is automatically recognized, a lifting operation for checking the state and volume of analyte is switched on the basis of the automatic recognition result, a mechanical operation parameter based on the blood collection tube type is determined, and the blood collection tube (1) is grasped and lifted. Then, an image processing threshold is changed on the basis of the automatic recognition result, and image processing is performed using a threshold parameter based on the blood collection tube type to check the state and volume of the analyte. This enables precise automatic checking of the state and/or volume of the analyte for various types of blood collection tubes.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: April 2, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Iwao Suzuki, Tsukasa Suenari, Takahiro Sasaki, Kenichi Takahashi
  • Patent number: 10240917
    Abstract: A measuring apparatus according to the present disclosure includes a support plate and an optical sensor. The support plate has an upper surface on a central portion of which an object is to be mounted, and is rotatable about an axis of rotation extending vertically from the central portion. The optical sensor is disposed above the support plate, and has a light-emitting element configured to irradiate the object with light and a light-receiving element configured to receive reflection light reflected from the object.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: March 26, 2019
    Assignee: Kyocera Corporation
    Inventors: Tomoya Yamada, Taku Matsudera
  • Patent number: 10241024
    Abstract: Described are systems and methods for optical characterization of inclusions, such as solids and liquids, in liquid samples. An inclusion characterization system may include a radiation source, a radiation detector, a sample optical cell, and a sample delivery mechanism. The radiation detector may be configured to perform time resolved measurements. The sample may be delivered to the sample optical cell by the sample delivery mechanism at a flow rate set for preserving the sample integrity (i.e., the transport rate). The inclusion characterization in the sample may be performed at flow rates set for sample analysis (i.e., the analysis rate). The analysis rate may differ from the transport rate. The rate difference may be achieved by diverting only a portion of the overall sample into the sample optical cell. Also provided are examples of disengagement of sample transport and analysis flow rates.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: March 26, 2019
    Inventor: Rashid Mavliev
  • Patent number: 10241011
    Abstract: The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: March 26, 2019
    Assignees: The Scripps Research Institute, Engineering Arts LLC
    Inventors: Bridget Carragher, Clinton S. Potter, Tilak Jain, Peter Kahn, Peter Wiktor
  • Patent number: 10227583
    Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: March 12, 2019
    Assignee: XCELLA BIOSCIENCES, INC.
    Inventors: Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford
  • Patent number: 10199198
    Abstract: A method of electron microscopy imaging of samples, using an electron microscope (100) having a microscope column (10) and a transfer device (11) with a grid carriage (12), comprises the steps of preparing multiple samples (1) on a single electron microscopy grid (2), including dispensing the samples (1) with a dispenser device (30) on distinct positions on the grid (2), introducing the grid (1) with the transfer device (11) into the microscope column (10), and electron microscopy imaging of the samples (1), wherein the preparing step includes holding the grid (2) on the grid carriage (12) of the transfer device (11) or on a grid holder device (20) provided at the electron microscope (100) and dispensing the samples (1) on the grid (2) while holding it on the grid carriage (12) or on the grid holder device (20). Furthermore, an electron microscope (100) for electron microscopy imaging of samples is described.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Scienion AG
    Inventors: Claude Dufresne, Holger Eickhoff
  • Patent number: 10175155
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: January 8, 2019
    Assignee: Aquaro Histology, Inc.
    Inventors: Nolan Orfield, Collin Rich, Vincent Alessi
  • Patent number: 10139348
    Abstract: A lightguide aggregate inspection device includes a reaction spot array including multiple reaction spot array elements having at least one reaction spot, a light-receiving element array having a light-receiving surface provided with multiple light-receiving regions each having at least one light-receiving element corresponding to each of the reaction spot array elements, and receiving light obtained based on an optical state resulting from reaction in each of the reaction spots, multiple lightguide paths provided to correspond to the reaction spot array elements, and each having a measurement end provided close to or in contact with, or to be movable close to or into contact with 1 reaction spot, and a connection end provided close to or in contact with the light-receiving region, and a digital data conversion unit configured to convert image region data obtained from the light-receiving elements corresponding to the light-receiving regions, into digital data.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: November 27, 2018
    Assignee: UNIVERSAL BIO RESEARCH CO., LTD.
    Inventor: Hideji Tajima
  • Patent number: 10132742
    Abstract: The present invention relates to a probe unit comprising a probe (2) having a probe window (3) having a contact surface for facing a high pressure fluid flow, the probe unit comprising a probe housing (1) containing the probe including the probe window, the probe being moveable relative to the probe housing between a first position wherein the window is exposed to the fluid flow and a second position wherein the probe is enclosed by said housing and a space (11) is defined between said housing and said probe, said housing having an outer part into said fluid flow, said probe unit comprising sealing means (4, 5, 7) adapted to seal said defined space from said fluid flow when the probe is in said second position. The probe unit also comprises pressure adjustment means for reducing the pressure within said space and cleaning means (6, 9) for cleaning said probe when within said space.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: November 20, 2018
    Assignee: ProAnalysis AS
    Inventors: Stian Magnussen, Hallvard Tangen, Anders Dalland, Bjørn Atle Øverland, Sindre Rognved Hansen, Øyvind Smith-Jahnsen
  • Patent number: 10119889
    Abstract: A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby recirculating fluid flow between the fluid channel inlet and the fluid channel outlet to carry sections between the sample sectioning module and the section mounting region.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: November 6, 2018
    Assignee: Aquaro Histology, Inc.
    Inventors: Collin Rich, Nolan Orfield, Vincent Alessi
  • Patent number: 10119964
    Abstract: A device termed the MobileArray™ device and methods, which form the MobileArray™ system, are disclosed for performing multiplex assays, target enrichment or purification. The device and methods disclosed enable the performing of multiplex assays, target enrichment or purification in a simplified manner. The MobileArray™ device gains the advantages and applications of the advanced multiplexing platforms, but does not require the special expensive equipment, reagents, software or dedicated operators. In addition, the MobileArray™ system can also be utilized in immunoprecipitation and target enrichment or purification in a multiplex manner. Furthermore, the MobileArray™ system can be integrated in an automated procedure. The MobileArray™ system makes it possible to apply multiplexing protocols in routine clinical practice, food safety inspection and general life science research laboratories.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: November 6, 2018
    Assignee: Digital Biotech, LLC
    Inventor: Raymond Lesser
  • Patent number: 10094764
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 9, 2018
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Patent number: 10082653
    Abstract: A system for performing quantitative phase-contrast confocal microscopy includes a light source that emits light, a first beam splitter that splits the emitted light into an illumination path and a hologram path, means provided along the illumination path for delivering a first part of the emitted light to an object as a collimated line, a light sensor that captures light reflected off of the object to obtain an intensity image for the collimated line, and means provided along the hologram path for delivering a second part of the emitted light to the light sensor at an off-axis angle to obtain an off-axis hologram for the collimated line.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: September 25, 2018
    Assignee: University of South Florida
    Inventors: Changgeng Liu, Myung K. Kim
  • Patent number: 10047331
    Abstract: A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally molded with the carrier structure from a thermoplastic material.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 14, 2018
    Assignee: UNISENSE FERTILITECH A/S
    Inventors: Jonas Lerche Hansen, Niels B. Ramsing, Søren Porsgaard, Holger Søe Plougsgaard, Mai Faurschou Isaksen
  • Patent number: 10000790
    Abstract: The subject invention provides materials and methods for detecting the presence of an electron donor. In a specific embodiment, the device detects the presence of dihydronicotinamide adenine dinucleotide (NADH) via a colorimetric change output by the sensing device. In another specific embodiment, the presence of an enzyme capable of catalyzing, or an agent capable of inhibiting, the production of NADH can also be detected by a colorimetric readout using the same device. In some embodiments, dihydronicotinamide adenine dinucleotide phosphate (NADPH) can also be detected using the device provided herein. Advantageously, preferred embodiments of the subject invention provide a low-cost, sensitive device for monitoring the presence of critical biological analytes in a variety of applications.
    Type: Grant
    Filed: June 28, 2015
    Date of Patent: June 19, 2018
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Pingping Liang, Haixiang Yu, Yi Xiao
  • Patent number: 10003363
    Abstract: An apparatus for transferring data from a first part of a measuring apparatus to a second part includes a signal transmitting part mounted to the second part and having first antennae for receiving first electrical signals representing data from the second part and emitting electromagnetic radiation corresponding to the first electrical signals, and a signal receiving part mounted to the first part but separated from and rotating relative to the signal transmitting part. The signal receiving part includes a second antenna for receiving electromagnetic radiation and generating second electrical signals corresponding to the first electrical signals.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: June 19, 2018
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Marco Panniello, Emanuele Ronchi, Carl Robert Tipton
  • Patent number: 9989470
    Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: June 5, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Chinmay Pangarkar, Karan Mohan
  • Patent number: 9971138
    Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 15, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Michael Griffin, Daniel Yue Man Chu, Tom McCollum
  • Patent number: 9971133
    Abstract: In order to provide a multireflection cell making it possible to decrease the volume of a cell main body into which measurement target gas is introduced as well as reducing the amount of light that is lost without being reflected in a multireflection mechanism, the multireflection cell includes the multireflection mechanism adapted to multiply reflect incident light and then emit the multiply reflected light outward. In addition the multireflection mechanism includes a field mirror, a first objective mirror that faces to the field mirror and is provided on a light incident side in the multireflection mechanism, and a second objective mirror that faces to the field mirror and is provided on a light emitting side in the multireflection mechanism. Further, the light incident into the multireflection mechanism is configured to be first reflected by the second objective mirror.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 15, 2018
    Assignee: HORIBA, Ltd.
    Inventor: Takeshi Akamatsu
  • Patent number: 9958467
    Abstract: Provided is a method for supplementing a sample with specific information. This method includes the following steps: intrinsically marking a sample by adding a chemical marker having a defined composition to the sample; storing data reflecting the composition of the chemical marker and information assigned to the chemical marker, wherein this marker-assigned information is not related to the composition of the chemical marker itself; analyzing the sample with an analysis method, wherein the analysis method is suited to detect the composition of the chemical marker, to obtain a marker-related result; comparing the marker-related result with the stored data; and assigning the marker-assigned stored information to the sample based on the preceding comparison.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: May 1, 2018
    Assignee: numares AG
    Inventors: Fritz Huber, Volker Pfahlert, Markus Fuhrmann, Renate Kirchhöfer