Fluid Containers (e.g., Cells Or Cuvettes) Patents (Class 356/246)
  • Patent number: 11369958
    Abstract: Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer to collectively define a set of wells. The second layer may define a channel, and the second layer may be substantially absorbent to infrared radiation. A third layer may be coupled to the second layer. The third layer may define an opening configured to receive a fluid. The third layer may be substantially transparent. The channel may establish a fluid communication path between the opening and the set of wells.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: June 28, 2022
    Assignee: Zoetis Services LLC
    Inventors: Robert Justice Shartle, Gregory Trigub
  • Patent number: 11327064
    Abstract: A monitoring system for monitoring a process includes a housing with a viewing panel. The viewing panel includes a view port. An emitter generates light and illuminates an observation zone of the process. A detector is disposed within the housing and is configured to detect light entering the housing through the view port and create a plurality of images of the process in the observation zone. A thermal regulation system is configured to generate heat in the vicinity of the viewing panel of the housing so as to increase the temperature of at least the view port above ambient temperature.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: May 10, 2022
    Assignee: J.M. CANTY, INC.
    Inventors: Thomas Canty, Michael Rizzo, Meredith McDonald, Colleen Kelley, Justin Halbach
  • Patent number: 11318456
    Abstract: An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: May 3, 2022
    Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka Makino, Hirotsugu Kubo, Tetsuya Ogawa, Masahiro Kinooka
  • Patent number: 11293872
    Abstract: A laser ablation probe comprises a tubular element adapted for conducting a carrier fluid in a substantially laminar flow. The tubular element comprises a fluid inlet and a fluid outlet arranged at opposite end portions of the tubular element for enabling the carrier fluid to flow through the tubular element. The tubular element further comprises a central portion having an aperture defined therein for admitting an aerosol generated by laser ablation from a material sample into the carrier fluid flow when this sample is positioned outside the tubular element at a distance in the range of 0 ?m to 100 ?m from the aperture.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 5, 2022
    Assignee: UNIVERSITEIT GENT
    Inventors: Frank Vanhaecke, Stijn Van Malderen
  • Patent number: 11285485
    Abstract: A test tube may include: an annular body having an open first end, a closed second end, a longitudinal surface extending between the open first end and the closed second end and enveloping a hollow interior of the annular body and a central longitudinal axis; wherein the longitudinal surface of the annular body may include: a first longitudinal portion that may include the open first end of the annular body and having a substantially circular cross-section; and a second longitudinal portion that may include: a first longitudinal side having a substantially circular-arc cross-section; and a second longitudinal side tapering in a longitudinal direction of the annular body towards the closed second end of the annular body.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: March 29, 2022
    Assignees: AID GENOMICS LTD, DANYEL BIOTECH LTD
    Inventors: Snir Zano, Daniel Gurevich
  • Patent number: 11280992
    Abstract: Specimen delimiting element which, at least in one region, has a nano-porous material which is transparent to at least one observation radiation which is capturable by means of a microscope. The nano-porous material has pores, the mean pore diameter of which is smaller than the wavelength of the observation radiation, and a proportion of at least 5% of the volume of the nano-porous material is taken up by the pores at least in portions of said nano-porous material.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 22, 2022
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Thomas Ohrt, Thomas Kalkbrenner
  • Patent number: 11262292
    Abstract: A fluid delivery method for delivering a liquid sample to a flow cell including a taper section including a first and a second inner walls opposing the first inner wall, which is inclined to the second inner wall so that a distance between the first and the second inner walls at a downstream side of the taper section is shorter than a distance at an upstream side of the taper section, and including measurement flow path provided downstream of the taper section, through which a liquid sample flows together with a sheath fluid. The fluid delivery method includes sample introduction of delivering the liquid sample into the taper section along the second inner wall until the liquid sample reaches the measurement flow path, and sample pressing by delivering the sheath fluid into the taper section along the first inner wall after the liquid sample reaches the measurement flow path.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: March 1, 2022
    Assignee: ARKRAY, Inc.
    Inventors: Shinichi Ota, Shigeki Masuda, Shinya Nakajima
  • Patent number: 11262310
    Abstract: An apparatus for analyzing optical properties of a sample includes a housing to receive a light source and a detector; a sample locus defined relative to the housing and positioned such that when a light source and a detector are in predetermined positions, the sample locus is subject to illumination by the light source and the detector is positioned to receive and detect light from the sample; a cover on the housing, the cover being movable in a hinged manner between an open position and a closed position; and a sample-receiving surface for receiving a free-standing sample in liquid or semi-solid form. When the cover is moved to the closed position it encloses the sample locus, with the sample-receiving surface being tilted away from horizontal during the closing movement and the sample being retained thereon by surface tension or adhesion and brought to the sample locus in an enclosed environment.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: March 1, 2022
    Assignee: ADVANCED NANO TECHNOLOGIES LIMITED
    Inventors: Norman McMillan, Martina O'Neill, Sven Riedel, Liam McDonnell
  • Patent number: 11249010
    Abstract: Various techniques are provided to implement, operate, and manufacture a chemical detection device. In one embodiment, a device includes a flow path comprising an analyte reporter configured to receive samples passed by the flow path. The device also includes an excitation source configured generate a response from the analyte reporter. The device also includes a detector configured to receive the response from the analyte reporter to determine whether the samples comprise a material of interest. The device also includes a support structure configured to position the flow path relative to the excitation source and the detector, wherein the support structure comprises a carbon filled polymer material. Additional devices, systems, and methods are also provided.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: February 15, 2022
    Assignee: FLIR Detection, Inc.
    Inventors: Chris Willis, Craig A. Aker
  • Patent number: 11235322
    Abstract: The present disclosure relates to an analytical system with at least three components: a multiwell plate on which the wells are included in an optically transparent area; a frame holding the multiwell plate close to its edge while permitting the plate a certain extent of freedom of movement; a baseplate to which the multiwell plate, but not the frame is firmly fixed via a docking mechanism, such that different expansion of plate and frame can be compensated. A second aspect described herein relates to a method of docking a corresponding multiwell plate held by a frame to a baseplate and subjecting the multiwell plate to a step of a biological or chemical assay within this arrangement.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: February 1, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Lukas Dysli, Christian Thalmann
  • Patent number: 11231361
    Abstract: Embodiments create an arrangement and a method for analyzing a fluid. The arrangement (10) for analyzing a fluid comprises beam splitter and mixer optics (12) configured to spatially mix an optical signal and split the same into at least two spatial sub-beams and a flow cell (14) configured to spectrally influence at least the two spatial sub-beams (15a; 15b) by means of a probe of the fluid. The arrangement further comprises a measurement system (16) configured to measure the at least two spatially separated sub-beams (15a; 15b).
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: January 25, 2022
    Assignees: Drägerwerk AG & Co. KGaA, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Gerd Peter, Margit Ferstl
  • Patent number: 11231356
    Abstract: An optical cell for performing light spectroscopy (including absorbance, fluorescence and scattering measurements) on a liquid sample in microfluidic devices is disclosed. The optical cell comprises an inlaid sheet having an opaque material inlaid in a clear material, and a sensing channel that crosses the clear material and the opaque material provides a fluidic path for the liquid sample and an optical path for probe light. Integral optical windows crossing a clear-opaque material interface permit light coupling into and out of the sensing channel, and thus light transmission through the sensing channel is almost entirely isolated from background light interference. A microfluidic chip comprising one or more optical cells is also disclosed. The optical cells may have different lengths of sensing channels, and may be optically and fluidly coupled. A method of manufacturing an optical cell in a microfluidic chip is also disclosed.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: January 25, 2022
    Assignee: DARTMOUTH OCEAN TECHNOLOGIES INC.
    Inventors: Edward Arthur Luy, Sean Christopher Morgan, Vincent Joseph Sieben
  • Patent number: 11226287
    Abstract: Sample cells, light scattering detectors utilizing the sample cells, and methods for using the same are provided. The sample cell may include a body defining a flowpath extending axially therethrough. The flowpath may include a cylindrical inner section interposed between a first outer section and a second outer section. The first outer section may be frustoconical. A first end portion of the first outer section may be in direct fluid communication with the inner section and may have a cross-sectional area relatively smaller than a cross-sectional area at a second end portion thereof. The body may further define an inlet in direct fluid communication with the inner section. The inlet may be configured to direct a sample to the inner section of the flowpath.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: January 18, 2022
    Assignee: M & J Scientific, LLC
    Inventors: Max Haney, Michael P. Murphy
  • Patent number: 11226282
    Abstract: A system includes a cuvette including a cuvette body forming a substantially planar exterior surface and having a sensor window defined within the substantially planar exterior surface. The cuvette further includes a probe retention structure extending from the cuvette body. The system includes a probe with a probe body and a protrusion that is removably coupled to the probe retention structure.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: January 18, 2022
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Andrea Galavotti, Gabriele Tommasi, Giampaolo Simonini, Marco Luppi, Andrea Zaniboni, Paola Capriati
  • Patent number: 11221279
    Abstract: A laser absorption spectroscopy exhaust gas sensor includes an optical cell with porous walls having pores with a mean diameter in the range of 0.1 nm to 1 mm; gold mirrors within the optical cell positioned to support a multi-pass optical path within the optical cell; an active heating element adapted to heat the optical cell to prevent condensation; a laser adapted to generate a laser beam; an optical detector adapted to detect a returning laser beam; and a processor for controlling the laser and the active heating element and for analyzing signals from the optical detector to identify a gas in the optical cell.
    Type: Grant
    Filed: January 11, 2020
    Date of Patent: January 11, 2022
    Assignee: Indrio Technologies, Inc
    Inventor: Ritobrata Sur
  • Patent number: 11209405
    Abstract: Before repeating the processing that an LC/MS analysis is performed after diluting a large number of pretreated media samples (S16 to S19), an LC-MS stabilization processing (S11) of supplying a mobile phase to the LC-MS and performing an analysis without a sample according to the same gradient profile as that in a culture medium sample analysis and a standard sample analysis (S13) of supplying a standard sample to the LC-MS and obtaining data for generating a calibration curve are performed. Before the LC-MS stabilization processing and before the standard sample analysis, respectively, a standby time corresponding to a required time of a sample dilution is provided (Steps S10 and S12). With this, the time of the cycle including the LC-MS stabilization processing and the time of the cycle including the standard sample analysis are made to be the same as the time of the cycle of a dilution and an analysis to a culture medium sample.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: December 28, 2021
    Assignee: Shimadzu Corporation
    Inventor: Kohei Yamamoto
  • Patent number: 11198123
    Abstract: The present disclosure relates to analytical testing devices comprising microfluidics and methods for performing an assay on a fluid sample received within the microfluidics, and in particular, to mitigating drift of fluid samples over a sensor by incorporating a bypass channel into the microfluidics. For example, a test cartridge device is provided that includes a fluid sample entry port and holding chamber connected to a bifurcation junction of a sensor channel and a bypass channel. The sensor channel includes an upstream region and a downstream region, and an analyte sensor is in the upstream region. As a cross-sectional area of the bypass channel is greater than the cross-sectional area of the downstream region of the sensor channel, the bypass channel is a preferred path for excess sample flow and pressure, and thus sample drift above the analyte sensor is mitigated.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: December 14, 2021
    Assignee: Abbott Point of Care Inc.
    Inventors: David Sabourin, Alain Villeneuve, Bruce Hendry, Jessica Chung, Graham E. Garrett, Vinoth Kumar Govindaraj, Katrina Petronilla Di Tullio, Sheila Diane Ball
  • Patent number: 11187224
    Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: November 30, 2021
    Assignee: ABS GLOBAL, INC.
    Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
  • Patent number: 11187646
    Abstract: A diagnostic kit includes: a diagnostic chip formed with a flow channel through which a diagnostic sample moves; a diagnostic sample movement regulation unit opening/closing one end of the flow channel to regulate movement of the diagnostic sample; an optical information detection unit detecting optical information on the diagnostic sample; and a controller controlling operation of the diagnostic sample movement regulation unit and the optical information detection unit, wherein the optical information detection unit includes: a light source illuminating the diagnostic sample; and a sensor sensing the optical information from the diagnostic sample, the diagnostic sample movement regulation unit is operatively associated with the optical information detection unit, and the diagnostic chip and the optical information detection unit are moved relative to each other upon operation of the diagnostic sample movement regulation unit.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: November 30, 2021
    Assignee: ABSOLOGY CO., LTD.
    Inventors: Seok Chung, Joon Seok Seo, Jae Un Jeong, Han Sang Jo
  • Patent number: 11162941
    Abstract: An immunoassay cartridge is disclosed that can enhance the reliability of an antigen-antibody reaction while increasing a speed of an antigen-antibody reaction. An immunoassay cartridge includes a reaction chamber and a fluorescence sensor assembly. A plurality of antibodies or antigens is attached to an inner surface including a bottom surface of the reaction chamber closest to the sensor. The fluorescence sensor assembly is disposed on a bottom surface of the reaction chamber. Since the bottom surface of the reaction chamber and the upper surface of the fluorescence sensor assembly are arranged to coincide with each other, even if fluid is repeatedly moved in a first direction after the fluid moves in a second direction in the reaction chamber and then moved in the first direction, there is no obstacle in the movement of the fluid. Thus, it is possible to increase the probability of antigen-antibody reaction in the reaction chamber.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: November 2, 2021
    Assignee: OPTOLANE TECHNOLOGIES INC.
    Inventors: Do Young Lee, Kyung Hak Choi
  • Patent number: 11150130
    Abstract: Aspects of the disclosure relate to a multi-pass gas cell that includes a set of two or more reflectors, an input collimating optical component, and an output focusing optical component. The input and output optical components are integrated with at least one of the two or more reflectors. For example, the input and output optical components may be integrated on opposite ends of a single one of the reflectors or may be integrated on the same end of a single reflector. The input and output optical components may further be integrated with different reflectors. In some examples, the set of reflectors and optical components may be fabricated within the same substrate.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: October 19, 2021
    Assignee: SI-WARE SYSTEMS
    Inventors: Yasser M. Sabry, Mohammad Sakr, Bassam A. Saadany, Momen Anwar, Mohamed H. Al Haron
  • Patent number: 11143638
    Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: October 12, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Tarun Khurana, Ali Agah, Aathavan Karunakaran, Stanley Hong, Merek Siu, Arvin Emadi, Craig Ciesla
  • Patent number: 11131680
    Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: September 28, 2021
    Assignee: C A Casyso GmbH
    Inventors: Axel Schubert, Jose J. Romero-Galeano, Max Kessler
  • Patent number: 11119032
    Abstract: An object of the present invention is to provide an optical multipass cell that is compact and low cost, does not require the installation of a cooling mechanism around the mirror, and can increase the number of reflections of laser light, and the present invention provides an optical multipass cell comprising a container (3) to which a sample gas is supplied and a pair of concave mirrors (5 and 7) arranged so as to face each other inside the container (3), a laser beam is incident into the container (3), and the laser beam is multiply reflected between the concave mirrors (5 and 7), wherein at least one convex lens (9) is arranged on the optical path of the laser beam that is multiply reflected between the pair of concave mirrors (5 and 7) so that the central axis (C2) thereof is inclined with respect to the central axis (C1) of the concave mirrors (5 and 7), and an acute angle formed by the central axis (C2) of the convex lens (9) and the central axis (C1) of the concave mirrors (5 and 7) is equal to or les
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: September 14, 2021
    Assignee: TAIYO NIPPON SANSO CORPORATION
    Inventor: Takehiro Igarashi
  • Patent number: 11112365
    Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: September 7, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rik Harbers, Kurt Schildknecht
  • Patent number: 11092519
    Abstract: A system for facilitating automated handling using laser ablation system is described that includes a sample generation system. In an embodiment, the sample generation system can include a sample chamber with a sample chamber body, a transmission window and a sealing member coupled to the sample chamber body, an inlet conduit extending through the sample chamber body and intersecting a sidewall of the interior space, and an outlet conduit extending through the sample chamber body and intersecting at least one of the sidewall of the interior or a lower surface of the sample chamber body; a placement system including a frame, and an actuator assembly coupled to the frame, where the actuator assembly is configured to place the sample adjacent to the sample chamber for laser ablation; and a laser configured to produce a laser beam that is propagated along a beam path to irradiate the sample.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: August 17, 2021
    Assignee: Elemental Scientific Lasers, LLC
    Inventors: Shane Hilliard, Jay N. Wilkins, Erik B. Larsen, Robert W. Hutchinson, Ciaran J. O'Connor
  • Patent number: 11080848
    Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: August 3, 2021
    Assignee: Lucira Health, Inc.
    Inventors: Ivan Krastev Dimov, Frank B. Myers, III, John Robert Waldeisen, Debkishore Mitra
  • Patent number: 11075054
    Abstract: A cell for use in a microscope has a pair of dies, the dies defining: a pair of slit-shaped windows disposed on opposite surfaces of the cell and arranged in perpendicular and spaced relation to one another to define a viewable volume interiorly of the cell at the region of overlap; a flow channel which includes the viewable volume and overlies and is substantially coterminous with one of the pair of slit-shaped windows; an elongate channel defined between the dies and leading towards the flow channel; and a conduit defined between the dies and coupling the elongate channel to the flow channel.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: July 27, 2021
    Inventors: Germán Sciaini, Ariel Petruk
  • Patent number: 11075019
    Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 27, 2021
    Assignee: The University of Hull
    Inventors: Stephen James Archibald, Ping He, Nathan Joel Brown, Mark Duncan Tarn, Stephen John Haswell, Mohammad Mehdi Nasr Esfahani, Nicole Pamme, Richard Alexander
  • Patent number: 11067494
    Abstract: A multi-dimensional micro fluid focussing device. The device includes an apparatus for multi-dimensional micro fluid focussing. The device also includes an analyser for analysing the focused fluid. The apparatus includes a microchannel having an inlet defining a first region, a middle region and an outlet defining a second region. A first junction is formed at the intersection of the first region and the middle region. A second junction is formed at the intersection of the middle region and the second region. A first sheath positioned proximal to the first junction and a second sheath positioned at the second junction. The junctions formed, along with the positioning of the sheaths enable the multi-dimensional focusing of the fluid. The analyser includes a holder for removably retaining the apparatus. A microscope is positioned across the holder. A recording unit is coupled to the microscope.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: July 20, 2021
    Assignees: INDIAN INSTITUTE OF SCIENCE, DEPARTMENT OF BIOTECHNOLOGY
    Inventors: Eluru Gangadhar, Sai Siva Gorthi
  • Patent number: 11057599
    Abstract: An image analysis system includes a video camera that collects YUV color images of a liquid sample disposed between a capital and a pedestal, the color images being collected while a light source shines light through an optical beam path between the capital and the pedestal, and a processor adapted to i) obtain from the YUV color images a grayscale component image and a light scatter component image, and ii) obtain at least one binary image of the grayscale component image and at least one binary image of the light scatter component image.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: July 6, 2021
    Assignee: Thermo Electron Scientific Instruments LLC
    Inventors: Alexander Grenov, Damian W. Ashmead, Kevin K. Kim, Francis J. Deck, Chris Xavier Kauffold
  • Patent number: 11056322
    Abstract: A method for dry processing a substrate in a processing chamber is provided. The substrate is placed in the processing chamber. The substrate is dry processed, wherein the dry processing creates at least one gas byproduct. A concentration of the at least one gas byproduct is measured. The concentration of the at least one gas byproduct is used to determine processing rate of the substrate.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: July 6, 2021
    Assignee: Lam Research Corporation
    Inventors: Yassine Kabouzi, Luc Albarede, Andrew D. Bailey, III, Jorge Luque, Seonkyung Lee, Thorsten Lill
  • Patent number: 11041187
    Abstract: A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: June 22, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Brian T. Cunningham, Yue Zhuo, Brendan Harley, Ji Sun Choi, Thibault Marin, Yi Lu
  • Patent number: 11035839
    Abstract: A method of determining saturate, aromatic, resin, and asphaltene (SARA) fractions of a hydrocarbon fluid sample, including: i) microfluidic mixing that forms a mixture including the hydrocarbon fluid sample and a solvent fluid that dissolves asphaltenes; ii) performing optical spectroscopy on the hydrocarbon fluid sample-solvent fluid mixture resulting from i); iii) microfluidic mixing that forms a mixture including the hydrocarbon fluid sample and a titrant fluid that precipitates asphaltenes; iv) microfluidically precipitating asphaltenes from the hydrocarbon fluid sample titrant fluid mixture resulting from iii); v) performing a microfluidic filtering operation that removes precipitated asphaltenes from the mixture resulting from iv) while outputting permeate; vi) performing optical spectroscopy on the permeate resulting from v); vii) determining an asphaltene fraction percentage of the hydrocarbon fluid sample based on the optical spectroscopy performed in ii) and vi); viii) sequentially separating satur
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: June 15, 2021
    Assignee: Schlumberger Technology Corporation
    Inventors: Vincent Joseph Sieben, Farshid Mostowfi, Nejib Hamed, Alexander Stickel, Collins Obiosa-Maife
  • Patent number: 11029245
    Abstract: A flow cell device including a spherical optical element is disclosed. The spherical lens can be sealed to the body of the flow cell device in a manner that provides external optical access to a fluid in an analysis region of a flow path through the flow cell device. The seal can be provided by an elastomer, a polymer, or a deformable metal. The disposition of the spherical lens to the flow path enables in situ optical analysis of the fluid. An optical analysis device can be removably connected to the flow cell device to provide the optical analysis. In some embodiments the optical analysis device is a portable Raman spectrometer. The flow cell device can provide a supplementary interrogation interface, and/or an on board sensor device(s) to enable multivariate analysis and/or advanced triggering.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: June 8, 2021
    Assignee: MarqMetrix, Inc.
    Inventors: Giora Proskurowski, Brian James Marquardt
  • Patent number: 11014843
    Abstract: A portable remote sensing system for real-time assessments of total suspended solids (TSS) in surface waters using above-water hyperspectral measurements. The system combines a miniature high signal-to-noise ratio spectrometer coupled to a credit card-size computer, lens, rechargeable battery, GPS, display panel, and dedicated software to derive TSS from above-water spectral measurements.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 25, 2021
    Inventor: Roy Armstrong
  • Patent number: 11000852
    Abstract: A system for use in spectral analysis procedures can include a slide and a holder for carrying the slide. The slide includes a substrate forming a plurality of wells that are recessed relative to a surface of the substrate. Each of the wells forms a sample region that is recessed by a sample depth from the surface and a trough region that is recessed by a trough depth from the surface, the trough depth being greater than the sample depth. The holder includes a body defining a cavity between a first side and a second side of the body, a port for receiving the slide into the cavity, one or more first fenestrations on the first side, and one or more second fenestrations on the second side.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: May 11, 2021
    Assignee: Protein Dynamic Solutions, Inc.
    Inventors: Belinda Pastrana-Rios, Jose Javier Rodriguez-Toro
  • Patent number: 11002752
    Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: May 11, 2021
    Assignees: POCARED Diagnostics LTD., Battelle Memorial Institute
    Inventors: Gal Ingber, William G. Atterbury, Dave Holley, Thomas A. Klausing, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico
  • Patent number: 10996230
    Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: May 4, 2021
    Assignee: C A CASYSO GMBH
    Inventors: Axel Schubert, Jose J. Romero-Galeano, Max Kessler
  • Patent number: 10976236
    Abstract: Light detection systems for measuring light (e.g., in a flow stream) are described. Light detection systems according to embodiments include a light scatter detector, a brightfield photodetector and an optical adjustment component configured to convey light to the light scatter detector and to the brightfield photodetector. Systems and methods for measuring light emitted by a sample (e.g., in a flow stream) and kits having a light scatter detector, a brightfield photodetector and a beam splitter component are also provided.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: April 13, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Jizuo Zou, Matthew Bahr, Eric D. Diebold
  • Patent number: 10969329
    Abstract: An ellipsometer includes: a gantry; a polarization generator and a polarization analyzer mounted in the gantry; and a focusing lens disposed on a sample on a stage, wherein the sample is an object to be measured, wherein a vertical section of the focusing lens is a semi-circle.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: April 6, 2021
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventor: Yongwoon Lim
  • Patent number: 10962475
    Abstract: A sensor including: a substrate including a first surface and a second surface opposing to each other, the first surface being recessed to form a first groove, and the substrate further including at least two through holes penetrating through the second surface and a bottom surface of the first groove; a dielectric layer disposed to cover the first surface, and opposing to the first groove; a metal layer disposed on the bottom surface of the first groove and avoiding openings of the through holes on the bottom surface of the first groove, wherein the dielectric layer, the metal layer and an interval between the dielectric layer and the metal layer form a slit optical waveguide; and a grating formed on the dielectric layer, wherein the grating is used to implement wave vector matching of an incident light with a mode of the slit optical waveguide.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: March 30, 2021
    Assignee: SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS(SINANO), CHINESE ACADEMY OF SCIENCES
    Inventors: Qin Chen, Li Liang, Long Wen, Xin Hu
  • Patent number: 10955334
    Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 23, 2021
    Assignee: Essenlix Corporation
    Inventors: Stephen Chou, Wei Ding, Ji Qi, Jun Tian, Wu Chou
  • Patent number: 10948505
    Abstract: Apparatuses and methods for washing a plurality of fluid samples are disclosed herein. In an embodiment, a system for washing a plurality of fluid samples respectively located within a plurality of cuvettes includes a rotor configured to rotate the plurality of cuvettes about an axis, a traveler mechanism located beneath the rotor, the traveler mechanism configured to move a plurality of magnets parallel to the axis of rotation of the rotor to position the plurality of magnets so that each cuvette of the plurality of cuvettes is located adjacent to at least one magnet of the plurality of magnets, and a wash system located above the rotor, the wash system configured to at least one of inject fluid into or aspirate fluid from the plurality of the cuvettes, while the plurality of magnets suspend magnetic particles located within each of the plurality of cuvettes.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: March 16, 2021
    Assignee: HYCOR Biomedical, LLC
    Inventors: Ronald Norman Diamond, Steve Michael Gann, Eric Darnell Hall, Tae Ho Hwang, John Lewis Morton, Anatoly Moskalev, Bruce Alan Sargeant, Dennis Edwin Rieger, Marinela Gombosev, Mark David Van Cleve
  • Patent number: 10946373
    Abstract: This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A method and device for photometric measurement of liquids. The method includes the steps of: The method includes the steps of; providing a pipette tip, the pipette tip being made of an optically clear body having an outer wall and an inner wall, the inner wall defining an inner space for receiving a liquid sample, the inner space providing a cross-sectional path length for light; positioning the pipette tip between a light source and a light collector; measuring light transmission through the liquid sample; adjusting the inner space of the pipette tip to change the cross-sectional length, and measuring light transmission through the liquid sample.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: March 16, 2021
    Assignee: Beacon Technologies, LLC
    Inventors: Dale Lee Heintzelman, John Lloyd Bowman, Rick Jackson
  • Patent number: 10935487
    Abstract: Systems and methods of the present disclosure are directed to detecting species within a fluid using a multi-pass absorption cell and a spectrometer. The absorption cell includes a plurality of mirrors arranged in a manner such that a detection light traverses multiple passes through the fluid within the absorption cell. In some implementations, the detection light is reflected by the plurality of mirrors to form optical paths in more than one plane. The system also includes an electronic unit configured to receive and process spectral data from the spectrometer. In some implementations, the electronic unit communicates with at least one computational unit over a communication interface to send a portion of the spectral data for processing. The electronic unit may also receive processed data from the computational unit.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: March 2, 2021
    Assignee: Duvas Technologies Limited
    Inventor: Craig Sawyers
  • Patent number: 10914732
    Abstract: The invention relates to a method for quantitatively determining biological analytes in an aqueous solution in the presence of one or more functionalised surfaces, wherein the aqueous solution comprises at least one type of biological analyte and at least one type of fluorescence marker, characterised in that the quantity and/or concentration of the biological analyte or analytes is determined by measuring the fluorescence emission of the unbound fluorescence markers, as well as to a devices for carrying out said method.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: February 9, 2021
    Assignee: PAIA BIOTECH GMBH
    Inventor: Sebastian Giehring
  • Patent number: 10907192
    Abstract: A linearity standard includes a plurality of calibration solutions, each calibration solution having a different level of a reactant having a known response in a test strip and meter combination, and an electronic storage medium for storing calibration instructions and known responses for each solution of the plurality of calibration solutions.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: February 2, 2021
    Assignee: POLYMER TECHNOLOGY SYSTEMS, INC.
    Inventors: Gary L. Hughes, Aniruddha Patwardhan, Keith Moskowitz
  • Patent number: 10908054
    Abstract: One or more homogenizing elements are employed in a flow through, multi-detector optical measurement system. The homogenizing elements correct for problems common to multi-detector flow-through systems such as peak tailing and non-uniform sample profile within the measurement cell. The homogenizing elements include coiled inlet tubing, a flow distributor near the inlet of the cell, and a flow distributor at the outlet of the cell. This homogenization of the sample mimics plug flow within the measurement cell and enables each detector to view the same sample composition in each individual corresponding viewed sample volume. This system is particularly beneficial when performing multiangle light scattering (MALS) measurements of narrow chromatographic peaks such as those produced by ultra-high pressure liquid chromatography (UHPLC).
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: February 2, 2021
    Assignee: WYATT TECHNOLOGY CORPORATION
    Inventors: Philip J. Wyatt, Vincent H. Hsieh, Mario Yasa, Barbara R. Maurer, David Cannell, Steven P. Trainoff
  • Patent number: 10859489
    Abstract: The present invention relates to a hand-held microfluidic detection device, comprising: —a microfluidic cell (M) having at least one chamber intended to at least contain a sample; —a support (S) comprising a housing for the removable attachment thereto of the microfluidic cell (M); —excitation light means arranged at least in part in the support (S) to side illuminate the at least one chamber of the microfluidic cell (M) to excite the sample contained therein; —an optical detector (D) configured and arranged to detect light emitted from the sample when excited with said side illumination; and —a casing (C) constituting an envelope into which at least the support (S) is housed and attached.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: December 8, 2020
    Assignees: FUNDACIÓ INSTITUT DE CIÈNCIES FOTÒNIQUES, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, IMAGINE OPTIC SPAIN SL
    Inventors: Romain Quidant, Luis Miguel Fidalgo, Rafael Porcar