Sample, Specimen, Or Standard Holder Or Support (e.g., Plates Or Slides) Patents (Class 356/244)
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Patent number: 8174691Abstract: A device is provided for detection and analysis of a component of interest in a sample comprising a small sample cell used with an ultra violet laser. The energy of the laser is spread over an area such that energy density is above desorption threshold, but the sample not ablated. The device provides for rapid and reliable detection of a component of interest, and a method of using the same. The sample cell provides decreased dispersion of the sample.Type: GrantFiled: March 14, 2008Date of Patent: May 8, 2012Assignee: Arkansas State University—JonesboroInventors: Matthew Horton, Robyn Hannigan
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Publication number: 20120105837Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: ApplicationFiled: November 1, 2011Publication date: May 3, 2012Applicant: POCARED DIAGNOSTICS LTD.Inventor: Gal INGBER
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Publication number: 20120105836Abstract: An apparatus for measuring the optical properties of an LED package includes: a light detection unit detecting light output from a plurality of LED packages of an LED package array in order to measure the optical properties of each of the LED packages; a mounting unit fixing the LED package array thereon when the optical properties thereof are measured; and a voltage application unit applying a driving voltage to the individual LED packages in the LED package array when the optical properties of the LED packages are measured.Type: ApplicationFiled: November 1, 2011Publication date: May 3, 2012Applicant: SAMSUNG LED CO., LTD.Inventors: Sang Bok YOON, Hae Yong EOM, Choong Hwan KWON
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Publication number: 20120099098Abstract: A unit is provided comprising an array (2) of sample containers (1), said containers, being connected together and arranged in a planar configuration, each container having multiple optically transparent windows arranged such that the sample contained therein can be interrogated using simultaneous multiple optical analytical techniques, the array of containers being configured so as to allow optical access to the windows of each container in the array. Also provided is an apparatus comprising such a unit, a system comprising a combination of such an apparatus and unit and a method of analysing multiple samples by introducing each individual sample into an individual container of such an apparatus, illuminating the samples and detecting and analysing light emerging therefrom.Type: ApplicationFiled: April 23, 2010Publication date: April 26, 2012Applicant: AVACTA LIMITEDInventor: Simon Webster
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Publication number: 20120099108Abstract: A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect includes the steps of: disposing lenslets within a biologic sample, which lenslets have a height and a refractive index, which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; imaging a portion of the sample including lenslets using transmittance at one or more wavelengths; determining an average light transmittance intensity of the sample at the wavelengths; determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets.Type: ApplicationFiled: October 24, 2011Publication date: April 26, 2012Applicant: ABBOTT POINT OF CARE, INC.Inventors: Stephen C. Wardlaw, Niten V. Lalpuria, Darryn W. Unfricht
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Publication number: 20120092658Abstract: We disclose an apparatus comprising: a hand-portable optical analysis unit including an optical interface; and a device configured to receive and releasably engage the hand-portable optical analysis unit. The device comprises: a housing; a sample unit in the housing; and a resilient member configured to bias the sample unit and the hand-portable analysis unit towards each other when the hand-portable optical analysis unit is received in the device to compress a sample disposed between the sample unit and the optical interface of the optical analysis unit. Methods of analyzing samples are also disclosed.Type: ApplicationFiled: December 19, 2011Publication date: April 19, 2012Inventors: Masud AZIMI, Arran BIBBY, Christopher D. BROWN, Peili CHEN, Kevin J. KNOPP, Daryoosh VAKHSHOORI, Peidong WANG, Stephen MCLAUGHLIN
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Publication number: 20120092674Abstract: Disclosed are methods and devices for measuring electromagnetic properties of samples. In one embodiment, a device is disclosed that includes a substantially two-dimensional measurement chamber comprising a reflective surface, where the reflective surface has a substantially elliptical shape that forms a part of an ellipse having a first focal point and a second focal point. The device further includes an input/output port located at the first focal point and a sample holder located at the second focal point.Type: ApplicationFiled: October 13, 2011Publication date: April 19, 2012Applicants: Katholieke Universiteit Leuven, K.U. Leuven R&D, IMECInventors: Amin Enayati, Steven Brebels, Walter De Raedt, Guy Vandenbosch
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Publication number: 20120092663Abstract: The disclosure provides instrumentation for the Raman spectroscopy analysis of seeds or grains, which can be used to determine the composition of the seed, such as its protein and oil content. In some examples the instrumentation includes an illumination device that emits light in the near infrared range, a sample holder to hold the seeds, and a collection device (e.g., Raman spectrograph) that captures the lights emitted by the seeds. Methods of determining the composition of seeds, such as soybeans, using Raman spectroscopy, are also provided.Type: ApplicationFiled: October 14, 2011Publication date: April 19, 2012Inventors: Linda S. Kull, Rohit Bhargava, Bridget Owen, Matthew Schulmerich, Dennis Thompson, John McKinney
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Patent number: 8159658Abstract: The present invention pertains to a system for the automated analysis of samples, comprising: a first optical device including at least one receptacle for receiving at least one of said samples and a receptacle-associated optical unit including at least one receptacle-associated light source for emitting light adapted for determining a color of said sample and generating a light beam for irradiating said sample contained in said receptacle and at least one receptacle-associated light detector for detecting light transmitted through said sample and generating a receptacle-associated detection signal; a second optical device including at least one test element provided with at least one test zone for applying said sample, said test zone being subject to an optically detectable change in response to at least one characteristic of said sample being different from said color and a test element-associated optical unit.Type: GrantFiled: May 3, 2010Date of Patent: April 17, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Fabian Durrer, Kurt Schildknecht, Urs Vollenweider
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Publication number: 20120081707Abstract: The present invention relates to shear flow device 100 comprising cell 110, wherein the cell is static and comprises stationary plates 110a and 110b, and movable slide 130. The device of the present invention can be used in methods of orienting molecules for LD measurement and in methods for creating an oriented macromolecule or macromolecule complex.Type: ApplicationFiled: July 1, 2011Publication date: April 5, 2012Inventor: Bengt Norden
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Patent number: 8149505Abstract: A laser scanner device (1) for imaging and/or measuring fluorescent samples located on slides and treated using fluorescent pigments includes a sample table (2) defining a sample plane (49) and a motorized transport device (3) for moving a slide from a storage unit (4) to the sample table (2) and back. The storage unit (4) includes one sample part (7) for sample slides (8) and one test part (9) for test slides (10), each having at least one depository (6) and being accessible during the operation of the laser scanner device (1) for the transport device (3). The test part (9) is implemented separately from the sample part (7) and as a test part magazine (9?) that is permanently connected to the laser scanner device (1) for one or more test slides (10).Type: GrantFiled: August 13, 2008Date of Patent: April 3, 2012Assignee: Tecan Trading AGInventors: Frank Fischer, Harald Gebetsroither, Andreas Gfrörer, Andreas Schenk
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Patent number: 8149411Abstract: The invention relates to a sensor unit for a Surface Plasmon Resonance (SPR) unit, comprising a transparent sensor structure forming at least one wall of a cavity, the wall being defined by a concave inner surface and a convex outer surface The inner surface is provided with a layer of a conductive material capable of supporting a surface plasmon. In the cavity there is provided a flow structure in said cavity so as to form at least one compartment for sample between the flow structure and the inner wall of the cavity. Also, a method for the detection of events at a surface by utilizing surface plasmon resonance is provided. It comprises placing a sample with an analyte of interest in a sensor unit as claimed in claim 1, and measuring the reflectance from said sensor unit at a single or plurality of angle/angles.Type: GrantFiled: October 29, 2007Date of Patent: April 3, 2012Assignee: Knut JohansenInventors: Knut Johansen, Mats Rånby
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Publication number: 20120075626Abstract: A method and an apparatus for optically reading test devices having an identification data zone associated with the test device and test zone arranged to receive a sample. The apparatus comprises an optical sensing module, an image processing module coupled to the optical sensing module, a control module coupled to the optical sensing module and to the image-processing module. The optical sensing module is arranged to sense both the test zone and the identification data zone and deliver the sensed data to the image processing module responsive to the control module. Further, the image-processing unit is arranged to perform image processing on the sensed data from the test zone and from the identification data zone and further determine the sample according to the sensed data from the test zone in view of the sensed data from the identification data zone responsive to the control unit.Type: ApplicationFiled: September 27, 2011Publication date: March 29, 2012Inventors: Ziv Geva, Ofer Leizerovich
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Patent number: 8144319Abstract: A system and a method are disclosed for combining a soil sample and extractant in a mixing chamber to produce a liquid extractant-soil mixture. A portion of the liquid extractant-soil mixture is directed from the mixing chamber through a sample measurement chamber coupled to the mixing chamber. The sample measurement chamber is coupled to a light source so that light propagates from the light source through the portion of the liquid extractant-soil mixture to an optical detector which generates an attenuation spectrum indicating light received by the detector at different wavelengths. The sample measurement chamber may include an attenuation cell having a specified optical path between a first measurement window and a second measurement window and angular surface directing particulates in the liquid extractant-soil mixture away from the attenuation cell.Type: GrantFiled: May 6, 2010Date of Patent: March 27, 2012Assignee: Solum, Inc.Inventors: Michael John Preiner, Nicholas Carleton Koshnick, Justin Stewart White, John Paul Strachan
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Publication number: 20120062878Abstract: A light irradiation apparatus capable of irradiating, while a component having a first side is held on the first side by a holding body of a component mounting apparatus, light onto a reflective plate to irradiate reflected light from the reflective plate from the first side of the component, the light irradiation apparatus including: a plurality of first light-emitting devices; a supporting body configured to support the plurality of first light-emitting devices such that optical-axis directions of the plurality of first light-emitting devices match; and a light guide body configured to guide light emitted from the plurality of first light-emitting devices to the reflective plate so that the reflected light is detected by a detector from a second side of the component on the other side of the first side.Type: ApplicationFiled: September 8, 2011Publication date: March 15, 2012Applicant: SONY CORPORATIONInventors: Akira Koshimura, Koya Nomoto, Kazuhito Kunishima, Daisuke Tanaka
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Publication number: 20120044493Abstract: Apparatus are described for measuring the characteristics of colloidal particles suspended in transparent media by Dynamic Light Scattering (DLS) and Depolarized Dynamic Light Scattering (DDLS) into regions where conventional measurements are difficult or impractical. Matching the diameter of an illuminating beam and an intersecting diameter of a field stop image extends measurements into regions that include concentrated turbid suspensions that frequently appear so visually opaque that multiple scattering typically gives a falsely low estimate of particle size.Type: ApplicationFiled: August 23, 2010Publication date: February 23, 2012Inventors: Anthony E Smart, William V. Meyer, Craig J. Saltiel
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Patent number: 8119995Abstract: The invention relates to a device (1) for detection of excitation (110) using a multiple spot arrangement (60), in which a multiple spot generator (50) is matched to the multiple spot arrangement (60) in such a way that light (100) entering the multiple spot generator (50) will be guided to defined areas on the multiple spot arrangement (60).Type: GrantFiled: July 17, 2006Date of Patent: February 21, 2012Assignee: Koninklijke Philips Electronics N.V.Inventors: Derk Jan Wilfred Klunder, Levinus Pieter Bakker, Sjoerd Stallinga
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Patent number: 8120769Abstract: A fiber measurement system for precision measurement of individual fiber properties, including length and fiber length distribution is provided. The fiber measurement system includes a fiber introduction system configured to introduce a plurality of individualized fibers. A fiber guidance enclosure is configured to receive the fibers from the fiber introduction system. The fiber guidance enclosure has an enclosed pathway and a viewing area. The viewing area has a height that limits mobility of the fibers in a Z-direction and the viewing area has a width that is wider than the enclosed pathway. A sensing system is provided for detecting the presence of the fibers within the fiber guidance enclosure. An imaging system is positioned proximal the viewing area of the fiber guidance enclosure to capture an image of the individualized fiber as the fibers pass through the viewing area. A controller is provided for analyzing the image data to determine at least one property of the fibers.Type: GrantFiled: August 3, 2007Date of Patent: February 21, 2012Assignee: North Carolina State UniversityInventors: Jon P. Rust, Michael J. Tompkins
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Publication number: 20120038913Abstract: An optical measurement instrument, which is equipped with transportation protection, includes a body structure (201), a mechanical support element(202) for supporting an optical interface, a moveably supported receptable element (211) for receiving a sample plate and located between the mechanical support element and the body structure, and a detachable transportation protection element (212-215) arranged to mechanically restrict movements of the receptable element and the mechanical support element. The transportation protection element is arranged to be pressed between the mechanical support element (202) and the body structure (201). Hence, for the transportation protection, there is no need to use e.g. a bolt that may be more laborious to install and remove than the transportation protection element to be pressed between the mechanical support element (202) and the body structure (201).Type: ApplicationFiled: February 18, 2010Publication date: February 16, 2012Applicant: WALLAC OYInventors: Aarne Torkkeli, Jyrki Laitinen, Christer Isaksson
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Patent number: 8115918Abstract: Encapsulated tissue is contained in an optically transparent cassette (34). The cassette (34) or an endcap (38) enclosing the cassette is marked with a fiducial (40) indicating and corresponding to the location of the excision on the patient's body. An image, which is preferably a representation of a surface of the tissue specimen and the vertical section(s) area of the tissue internal of the specimen and adjacent to a surface thereof, is obtained by an imaging system (10). The cassette is moved, preferably in a stage (22) which rotates the cassette while translating it, so that the head (12) of the imaging system provides a linear scan in a direction perpendicular to the wall of the cassette (also perpendicular to the surface of the tissue encapsulated in the cassette). The imaging system's display (28) indicates the morphology at and in proximity to the surface of the specimen as well as the location thereof.Type: GrantFiled: April 23, 2007Date of Patent: February 14, 2012Assignee: Lucid, Inc.Inventors: James M. Zavislan, Roger J. Greenwald
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Patent number: 8115922Abstract: The invention relates to an apparatus and method for adapting conventional spectrophotometer cuvettes for use in a vertical light beam spectrophotometer.Type: GrantFiled: February 29, 2008Date of Patent: February 14, 2012Assignee: Starna Cells, Inc.Inventors: John Russell Webster, Alan Keith Hulme
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Publication number: 20120033209Abstract: Containerized systems are provided. In one embodiment, a containerized system includes a moveable three-dimensional container, a first generator, a second generator, and a scanner. The first generator is located within the container, and the second generator is located outside of the container. The scanner is mechanically supported by the container and transmits waves received from the first and the second generators. The containerized system optionally includes one or more rails connected to the outside of the container, and the scanner moves along the one or more rails. The containerized system may also include a multi-axes arm that positions the scanner and that is mechanically supported by the container. Furthermore, the containerized system may include an interferometer, an electronics rack, and/or an air conditioning unit.Type: ApplicationFiled: August 8, 2011Publication date: February 9, 2012Applicant: PaR Systems, Inc.Inventors: Mark A. Osterkamp, Kenneth R. Yawn, Alan J. Norris
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Publication number: 20120033208Abstract: It is an object of the present invention to test a device under test including an optical interface. Provided is a device interface apparatus on which is loaded a device under test including an optical interface. The device interface apparatus comprises a device loading section on which the device under test is loaded; an optical connector that is to be connected to the optical interface of the device under test; and an optical connector moving section that moves the optical connector toward the optical interface of the device under test loaded on the device loading section, to optically connect the optical connector and the optical interface.Type: ApplicationFiled: August 2, 2011Publication date: February 9, 2012Applicant: ADVANTEST CORPORATIONInventors: Hideo HARA, Shin MASUDA
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Patent number: 8110159Abstract: An imaging system includes a platform for placement of a sample or an animal to be imaged, and at least one excitation light source for irradiating the sample or animal to stimulate an emission at a plurality of different center wavelengths. An acousto-optic tunable filter (AOTF) is provided that includes a piezoelectric transducer crystal for emitting an acoustic wave having a ground electrode disposed on one side of the piezoelectric crystal. A patterned electrode layer is disposed on a side of the piezoelectric crystal opposite the ground electrode. The patterned electrode layer includes a continuous region proximate to its center and a discontinuous region, a pattern in the discontinuous region comprising a plurality of spaced apart features electrically connected to the continuous region, and an AO interaction crystal receiving the acoustic wave attached to the ground electrode or the patterned electrode layer.Type: GrantFiled: September 2, 2008Date of Patent: February 7, 2012Assignee: Gooch and Housego PLCInventors: Elliot S. Wachman, Jill Wachman, Stanley J. Geyer
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Patent number: 8107066Abstract: A tray-shaped container comprising at least one cavity or recess for receiving the particular test objects, wherein these at least one recess comprises structured inner surfaces. Through this, a considerable reduction or even full reduction of interfering reflections and other optical irritations is achieved. In particular, the container constitutes an incubation tray for test stripes, having several longitude extending recesses. The inner surfaces of the recesses preferably comprise a grove-shaped and/or stair-shaped structure. The tray-shaped container may constitute an incubation tray for test stripes which are used in medical diagnostics.Type: GrantFiled: August 14, 2008Date of Patent: January 31, 2012Assignee: Bioscitec GmbHInventors: Felix Dirla, Robert Jaeger
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Patent number: 8107082Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: GrantFiled: July 21, 2011Date of Patent: January 31, 2012Assignee: Plexera LLCInventors: Gilbum Kim, Hannwen Guan, Shuxin Cong
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Publication number: 20120017842Abstract: A measurement object holder that holds a measurement object in an optical measurement instrument, wherein the optical measurement instrument takes, as the measurement object, a living body in which isotropic scattering of light occurs inside and receives light emitted from the measurement object is disclosed. The measurement object holder includes a block that is formed in a predetermined outer shape by a material having optical properties in which the isotropic scattering of light occurs inside; and a cavity portion that is formed inside the block, that has an inner shape following the outer shape of the measurement object and in which the measurement object is accommodated.Type: ApplicationFiled: February 1, 2010Publication date: January 26, 2012Applicant: FUJIFILM CORPORATIONInventors: Yukio Yamada, Hitoshi Shimizu, Takeshi Kimura
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Publication number: 20120019823Abstract: A box 14 having a body 13 is used with a transparent flexible bag containing a liquid such as an IV bag. First and second faces 12 are positioned relative to each other. The faces each have therewithin an end or fiber optic port 11 of a respective light path. A light source is optically coupled with the light path of the first face and a spectrometer is optically coupled with the light path of the second face. The light paths are coaxial and are disposed so that the transparent flexible bag is positionable therebetween. The spectrometer is disposed to detect an anomaly in the liquid within the transparent flexible bag, and to annunciate the anomaly to a human user. The box defines a reproducible light path length through the liquid. A caliper 29 having a body 22 may be used in spectrometric analysis of a transparent tube containing a liquid such as a syringe or an IV line. The caliper has finger pads 27 which permit opening the spring-loaded caliper as needed.Type: ApplicationFiled: May 21, 2011Publication date: January 26, 2012Applicant: VERRANA, LLCInventors: William H. Flank, Sandra Glassman Flank, Sharon Flank, Emil W. Ciurczak, Carl Oppedahl
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Patent number: 8102523Abstract: A method for using a reusable sample-holding device for readily loading very small wet samples for observation of the samples by microscopic equipment, in particular in a vacuum environment. The method may be used with a scanning electron microscope (SEM), a transmission electron microscope (TEM), an X-ray microscope, optical microscope, and the like. For observation of the sample, the method provides a thin-membrane window etched in the center of each of two silicon wafers abutting to contain the sample in a small uniform gap formed between the windows. This gap may be adjusted by employing spacers. Alternatively, the thickness of a film established by the fluid in which the sample is incorporated determines the gap without need of a spacer. To optimize resolution each window may have a thickness on the order of 50 nm and the gap may be on the order of 50 nm.Type: GrantFiled: September 22, 2011Date of Patent: January 24, 2012Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Charles P. Marsh, Eric Olson, Todor I. Donchev, Ivan Petrov, Jianguo Wen, Ryan Franks, Dongxiang Liao
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Publication number: 20120013897Abstract: The present invention relates to a distance adjustment system and a solar wafer inspection machine provided with the system. The inspection machine has a conveyer for carrying a solar wafer, an optical inspection system for inspecting the surface and color appearance of the wafer and an illumination inspection system. A holder is provided in the inspection position where the wafer is clamped along its width direction to prevent the wafer from offset. During the opto-electrical inspection, probes are brought into contact with conductive buses of the wafer and light is applied to the wafer to allow the probing of electric energy thus generated. An adjusting device is employed to adjust the clamping gap of the holder and the distance of the probes in accordance with the size of the solar wafer. The data are collected and transmitted to a sorting system for sorting the wafer.Type: ApplicationFiled: February 18, 2011Publication date: January 19, 2012Applicant: CHROMA ATE INC.Inventor: Chia-Hung Lai
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Patent number: 8094299Abstract: Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss.Type: GrantFiled: July 24, 2008Date of Patent: January 10, 2012Assignee: Beckman Coulter, Inc.Inventors: Mark A. Wells, Carlos A. Perez, Jose M. Cano
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Patent number: 8092763Abstract: An apparatus for positioning a cuvette in an optical beam path of an optical measuring instrument, with a shaft for axially inserting a cuvette, and means for pressing a cuvette against at least one wall surface of the shaft, which comprise at least one arrangement of a magnet, stationarily arranged with respect to the shaft, and a magnet movable with respect to the same, which are oriented such that the movable magnet tends to occupy a certain position with respect to the stationary magnet, in which the movable magnet engages at least partially into the shaft.Type: GrantFiled: November 24, 2008Date of Patent: January 10, 2012Assignee: Eppendorf AGInventors: Andreas Bombach, Peter Scheffler
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Publication number: 20120002199Abstract: The present invention provides an optical unit (320) adapted to accommodate a sample and to enable optical detection of infection within said sample; said optical unit comprising a body (100); said body is characterized by a distal end and a proximal end interconnected via a main longitudinal axis; said body (100) comprising at least one mirror (50) coupled to said distal end; wherein said mirror (50) having a proximal and distal surfaces; said proximal surface faces said mask; said proximal surface is adapted to accommodate said sample.Type: ApplicationFiled: January 5, 2010Publication date: January 5, 2012Applicant: OPTICUL DIAGNOSTICS LTD.Inventors: Moshe Ben-David, Tomer Eruv, Gallya Gannot
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Publication number: 20120001089Abstract: A body module of an optical measurement instrument includes: a reception device (201) for receiving samples, a first plate (202), a second plate (203) substantially parallel with the first plate and movably supported relative to the first plate in a direction perpendicular to the first and second plates, and walls extending from outer edges of the first plate to outer edges of the second plate. The reception device is located in a measurement chamber constituted by the walls and the first and second plates. At least the second plate includes a fastening interface provided with an aperture. The fastening interface is suitable for an optical module to be mounted to the second plate. The measuring chamber provides protection against undesired stray light from surroundings. The movability of the second plate allows adjustment of a distance between a sample and an optical module mounted to the second plate.Type: ApplicationFiled: January 18, 2010Publication date: January 5, 2012Applicant: WALLAC OYInventor: Jyrki Laitinen
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Publication number: 20120002190Abstract: An optical measurement instrument includes a measurement head and mechanical support elements arranged to support a sample well plate. The measurement head is moved towards the sample well plate and, after the measurement head has touched the sample well plate, the measurement head is moved backwards away from the sample well plate so as to provide a desired distance between the measurement head and the sample well plate. A sensor device is attached to the mechanical support elements and arranged detect a mechanical effect occurring in the mechanical support elements due to force directed by the measurement head to the sample well plate. Hence, the situation in which the measurement head touches the sample well plate can be detected without a need to provide the measurement head with a force sensor. This is advantageous because the measurement head can be a changeable module of the optical measurement instrument.Type: ApplicationFiled: January 18, 2010Publication date: January 5, 2012Applicant: WALLAC OYInventors: Jyrki Laitinen, Markku Ojala, Jarkko Sarmaala, Christer Isaksson
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Patent number: 8089624Abstract: The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum.Type: GrantFiled: October 12, 2010Date of Patent: January 3, 2012Assignee: Hitachi, Ltd.Inventors: Toru Fujimura, Kosuke Kuwabara, Tatsuro Ide
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Publication number: 20110317157Abstract: According to example embodiments of the invention, a microscale testing stage comprises a frame having first and second opposing ends and first and second side beams, at least one deformable force sensor beam, a first longitudinal beam having a free end, a second longitudinal beam having a facing free end, a support structure, and a pair of slots disposed at each of the free ends. In certain embodiments, a separately fabricated microscale or nanoscale specimen comprises a central gauge length portion of a material to be tested, and first and second hinges providing a self-aligning mechanism for uniaxial loading. In other embodiments, a layer of a conductive material defines first and second conductive paths and an open circuit that can be closed by the specimen across the gap. In other embodiments, the stage is formed of a high melting temperature material.Type: ApplicationFiled: June 25, 2010Publication date: December 29, 2011Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Wonmo Kang, M. Taher A. Saif
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Publication number: 20110312071Abstract: A microfluidic device for molecular diagnostic analysis of a biological sample containing cells, the microfluidic device having a supporting substrate, a plurality of microsystems technology (MST) channels each with a cross-sectional area between 1 square micron and 400 square microns for biochemical processing of constituents within the biological sample, and, a plurality of cell transport channels, each with a cross-sectional area greater than 400 square microns for receiving the biological sample and transporting cells within the biological sample to predetermined sites in the MST channels.Type: ApplicationFiled: June 1, 2011Publication date: December 22, 2011Inventors: Kia Silverbrook, Mehdi Azimi
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Publication number: 20110304857Abstract: One aspect of the present disclosure provides a probing apparatus with on-probe device-mapping function. A probing apparatus according to this aspect of the present disclosure comprises a housing, at least one probe stage positioned on the housing and configured to retain at least one probe, a device holder positioned in the housing and configured to receive at least one semiconductor device under test, and an inspection module having a predetermined field of view configured to capture an image showing at least the semiconductor device, wherein the probe stage includes a driving unit configured to move the probe out of focus of the inspection module in a mapping phase while keeping the device under test in the field of view of the optical inspection module.Type: ApplicationFiled: June 9, 2010Publication date: December 15, 2011Applicant: STAR TECHNOLOGIES INC.Inventors: Yong Yu Liu, Choon Leong Lou, Lai Peng Chew
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Patent number: 8064048Abstract: A particle-moving type orientation sensor including a housing, at least one light emitter, two light receivers, and a plurality of particles. The housing has an accommodating space having four zones, which are circularly arranged. A first opening is formed on the housing and connecting to a first zone. Two second openings are formed on the housing and respectively connecting to a second zone and a fourth zone. The light emitter emits light into the accommodating space through the first opening. The light receivers respectively receive light from the accommodating space through the second openings. The particles are arranged in the accommodating space. While the particle-moving type orientation sensor is tilting, the light emitter is partially blocked by the particles, and one of the light receivers is partially blocked by the particles, the light receivers respectively receive light with predetermined intensities and output electric signals with predetermined strengths.Type: GrantFiled: November 30, 2009Date of Patent: November 22, 2011Assignee: Edison Opto CorporationInventors: Tsung-Ting Sun, Chung-Ping Feng
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Patent number: 8062900Abstract: A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of predetermined size. The aperture regulates the light that enters and exits the sensor upon successive scans and ensures repeatable readings from the sensor. In an extended embodiment, a method of detection is disclosed that utilizes a launch and receive system while employing the aforementioned microplate.Type: GrantFiled: May 17, 2006Date of Patent: November 22, 2011Assignee: Corning IncorporatedInventor: Robert A. Modavis
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Patent number: 8064050Abstract: A method of visualizing the deposition of an additive from a personal care composition onto substrates such as hair, skin mimic and fabric through the use of a flow cell device.Type: GrantFiled: July 16, 2009Date of Patent: November 22, 2011Assignee: The Procter & Gamble CompanyInventors: Dirk Wilhelm Domaschko, Renee Danielle Bolden
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Publication number: 20110282247Abstract: The invention is a hand held ovulation predictor device, which includes an ovulation predictor device body, an optical subassembly containing one or more aspheric lenses, an electronics assembly, a battery compartment, a light source and, optionally, a cover. The preferred embodiment of this invention is one in which the one or more lenses are aspheric.Type: ApplicationFiled: March 31, 2011Publication date: November 17, 2011Inventors: Helen Denise, Russ Case
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Patent number: 8059924Abstract: Photonic detection systems and methods are shown. A flow through photonic membrane is provided with pores which are distributed along multiple regions. The pores of one region have walls to which a first type of target specific anchor can be attached, while pores of another region have walls to which a second type of target specific anchor can be attached. An additional region of pores without anchors can be provided, so that optical detection occurs differentially. A stack of photonic membranes is also provided. The diameter of the pores of one photonic membrane is larger than the diameter of the pores of another photonic membrane, thus allowing also determination of the size of a target organism flown through the stack of membranes.Type: GrantFiled: September 8, 2008Date of Patent: November 15, 2011Assignee: Lawrence Livermore National Security, LLCInventors: Sonia E. Letant, Tiziana C. Bond
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Patent number: 8059270Abstract: There is provided a microchip that is formed of a first substrate having a surface with a groove and a second substrate joined together and has a fluid circuit in the form of a cavity defined by the groove and a surface of the second substrate closer to the first substrate. The fluid circuit at least includes a detection portion having an optical path for transmitting light. The microchip includes at least one of a step defined by a groove formed in contact with at least one side surface of a groove of the first substrate that defines the optical path and a recess provided in the second substrate at a position opposite to the step.Type: GrantFiled: November 24, 2008Date of Patent: November 15, 2011Assignee: Rohm Co., Ltd.Inventors: Yasuhisa Kageyama, Toshihiro Mori
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Patent number: 8059271Abstract: A reusable sample-holding device for readily loading very small wet samples for observation of the samples by microscopic equipment, in particular in a vacuum environment. Embodiments may be used with a scanning electron microscope (SEM), a transmission electron microscope (TEM), an X-ray microscope, optical microscope, and the like. For observation of the sample, embodiments provide a thin-membrane window etched in the center of each of two silicon wafers abutting to contain the sample in a small uniform gap formed between the windows. This gap may be adjusted by employing spacers. Alternatively, the thickness of a film established by the fluid in which the sample is incorporated determines the gap without need of a spacer. To optimize resolution each window may have a thickness on the order of 50 nm and the gap may be on the order of 50 nm.Type: GrantFiled: February 4, 2009Date of Patent: November 15, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Charles P. Marsh, Eric Olson, Todor I. Donchev, Ivan Petrov, Jianguo Wen, Ryan Franks, Dongxiang Liao
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Publication number: 20110275162Abstract: Low-cost assay test strip readers are disclosed. Such readers enable creation of profiles of analyte reactions detected on an assay test strip utilizing a simple detector fixedly mounted to a body of the reader. The detector may be a single detector, such as a photodetector, which detects an optical signal at a single point. The assay test strip is inserted and/or removed from the test strip reader and the detector detects the optical elements of the strip during such insertion and/or removal. The movement of the test strip with respect to the body enables the detector to scan a length of the test strip, such that a one-dimensional profile of the optical signals can be generated. The reader may convert the detected profile into a displayable indication of analyte concentrations for diagnostic purposes. Moving the test strip relative to an array of detectors enables creation of a two-dimensional profile.Type: ApplicationFiled: May 5, 2010Publication date: November 10, 2011Applicant: ALVERIX, INC.Inventors: Tong Xie, Benny Wing Hung Lai
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Publication number: 20110273706Abstract: The invention is a microplate mounting system for mounting a microplate relative to an optical reader to control an angle of incidence of an interrogation beam at the microplate and includes a reference plane with at least one set of mount features that engage one or both of the bottom of the microplate and the skirt of the and a first positioning mechanism that provides a reversible and predetermined separation in the z direction between a plane formed by the bottom of the microplate and the reader, to control the angle of incidence of the interrogation beam at the microplate by reversibly controlling the relative positioning of the microplate in the z direction through the engagement between the bottom and/or skirt of the microplate and the at least one set of mount features.Type: ApplicationFiled: February 22, 2011Publication date: November 10, 2011Inventors: David Noblett, Robert E. Krug, Steven Liebold, Mark Francis Krol, David Andrew Pastel, Ravi Marala, Ken Neumann, Dawn Neumann
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Publication number: 20110267443Abstract: An exemplary apparatus for detecting stray light in an lens module includes a worktable having a top surface, a protractor dial defined in the top surface, a lens module supporting seat on the top surface, a light source supporting seat on the top surface, a track defined in the top surface along a circumference of the dial, a light source on the light source supporting seat, an image pick-up unit. The dial includes an origin point and many scale lines. The lens module supporting seat is arranged on the top surface at the origin point for supporting the lens module. The light source is movable along the track, and configured for emitting light along a scale line towards the lens module. The image pick-up unit is configured for capturing images of the light from the light source through the lens module at respective different incident angles.Type: ApplicationFiled: August 19, 2010Publication date: November 3, 2011Applicant: HON HAI PRECISION INDUSTRY CO., LTD.Inventor: TSUNG-YU LIN
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Patent number: 8049884Abstract: A liquid sample is dropped onto the upper surface of a transparent and cylindrical light-transmitting body (22), and the liquid sample is maintained as a droplet by the surface tension. From above the liquid sample, a transparent cover plate (25) is lowered down to the position where the lower surface thereof touches a spacer (23) in order that the liquid sample is held in the small gap formed between the upper surface of the light-transmitting body (22) and the lower surface of the transparent cover plate (25). A measurement light is provided into the liquid sample held in this manner from immediately above it, and passes through the liquid sample. The transmitted light emitted downwards through the light-transmitting body (22) is introduced into a spectro-detecting unit to be spectro-measured. The measurement optical path length can be adjusted by the height of the spacer (23). This enables an easy transmission spectro-measurement of an extremely small amount of liquid sample.Type: GrantFiled: September 27, 2007Date of Patent: November 1, 2011Assignee: Shimadzu CorporationInventor: Yasuo Tsukuda