Blood Analysis Patents (Class 356/39)
  • Patent number: 11141075
    Abstract: An integrated circuit device includes an insulating body provided with a number of electrically conductive leads and having a surface provided with a red LED aperture, an IR LED aperture and a photodetector aperture. The insulating body also includes an optical isolator optically separating the photodetector aperture from the red LED aperture and the IR LED aperture. A red LED is aligned with the red LED aperture, an IR LED is aligned with the IR LED aperture, and a photodetector is aligned with the photodetector aperture.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 12, 2021
    Assignee: Maxim Integrated Products, Inc.
    Inventors: Arpit Mehta, Richard I. Olsen, Daniel S. Christman
  • Patent number: 11134901
    Abstract: Methods and systems of optically measuring systolic and/or diastolic blood pressure of a mammal having biological tissue are disclosed herein. In some embodiments, the system comprises an optical blood motion sensor, a gas-sealable inflatable cushion having a flexible and transparent (FOT) barrier section, and an optical blood motion sensor comprising a laser. When pressure (e.g. at least systolic pressure) illuminates the tissue, laser light may pass en route to the tissue through the FOT sealing barrier section of the gas-sealable inflatable cushion as well as cushion interior. In some embodiments, a rigid restrictor comprising an optically transparent section is provided, and laser light also passes through the optically transparent section of the rigid restrictor en route to the biological tissue.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 5, 2021
    Assignee: ELFI-TECH LTD.
    Inventors: Ilya Fine, Alexander Kaminsky
  • Patent number: 11137338
    Abstract: [Object] To provide an information processing apparatus, a particle sorting system, a program, and a particle sorting method that practice a spectral type analysis usable for sorting particles. [Solving Means] The information processing apparatus according to an aspect of the present technology includes: an analysis unit; a learning unit; and a discrimination unit. The analysis unit calculates fluorophore information indicating respective amounts of luminescence of a plurality of types of fluorophores on the basis of detection data indicating amounts of luminescence of fluorescence at respective wavelength bands, the fluorescence having been emitted from a particle irradiated with excitation light, discriminates whether or not to treat the particle as a process target in accordance with the fluorophore information, and generates teaching data by associating a result of the discrimination with the detection data.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 5, 2021
    Assignee: Sony Corporation
    Inventors: Kenji Yamane, Shigeatsu Yoshioka, Yasunobu Kato
  • Patent number: 11105728
    Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: August 31, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Eric D. Diebold, Keegan Owsley, Jonathan Lin
  • Patent number: 11060967
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: July 13, 2021
    Assignee: NUEON INC.
    Inventors: Robert G. Messerschmidt, Howland D. T. Jones
  • Patent number: 11049249
    Abstract: A method, an apparatus and a system for cell detection are provided. In the apparatus, a hyperspectrum module is used to capture information across electromagnetic spectrums from an image, a stereo camera module is used to capture three-dimensional image information, and the hyperspectrum module and the stereo camera module form a trinocular micro spectrometer. A microscopic optical module is provided for the two modules to form hyperspectrum and three-dimensional image information from a cell and its split cells via a lens. In the method, a series of continuous images are obtained within a time period. An observation image array with a plurality of observation image zones are provided to retrieve coordinates of a plurality of feature points at different times. Finally, a holistic cellular activity can be obtained by analyzing continuous hyperspectrum and 3D image information from the images over time.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: June 29, 2021
    Assignees: PROVIDENCE UNIVERSITY, NATIONAL TSING HUA UNIVERSITY
    Inventors: Wei-Chung Wang, Yung-Hsiang Chen, Chuan-Yi Tang, Ching-Huan Kuo
  • Patent number: 11047798
    Abstract: A specimen containing a substance to be measured is introduced into a flow path of a measurement chip including a flow path which is a cavity for accommodating liquid and a reflecting unit which specularly reflects light which passes through the flow path so as to pass through the flow path again and a measurement value indicating an amount of the substance to be measured in the specimen is acquired. Then, second light acquired when first light including light of a wavelength absorbed by a red blood cell passes through the specimen in the flow path, is reflected by the reflecting unit, and passes through the specimen in the flow path again is detected in a state in which the specimen is present in the flow path. Next, a hematocrit value of the specimen is determined on the basis of a detection result of the second light. Next, a measurement value is corrected on the basis of the hematocrit value.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: June 29, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Fumio Nagai, Tetsuya Noda, Hideyuki Fujii
  • Patent number: 11039793
    Abstract: There is provided a method and apparatus for calibrating measurements made using a medical monitoring device. A conversion factor may be obtained including a first cross correlation that describes the correlation between measurements made using a first medical monitoring device and measurements made using a second medical monitoring device. The first conversion factor may then be used to convert measurements from the first medical monitoring device onto the same scale as measurements from the second medical monitoring device.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: June 22, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Meru Adagouda Patil, Nagaraju Bussa, Prasad Raghotham Venkat
  • Patent number: 11035778
    Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: June 15, 2021
    Assignee: Kinetic River Corp.
    Inventor: Giacomo Vacca
  • Patent number: 11013460
    Abstract: A system for noninvasively measuring blood alcohol concentration using light includes one or more emitters each configured to emit light in the near infrared or infrared light spectrum at one or more wavelengths that respond to varied chromophore concentrations of ethanol and water in blood of a human subject. One or more detectors is configured to detect light emitted at the one or more wavelengths and output a representation of a photoplethysmography (PPG) waveform for one or more of the one or more wavelengths. A processing subsystem is coupled to the one or more emitters and the one or more detectors.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: May 25, 2021
    Assignee: Vivonics, Inc.
    Inventor: Ryan Myers
  • Patent number: 11016030
    Abstract: A detection method with a compensation function includes the following steps. After a sample is added to a first cassette, a first triggering instruction is provided to define a first time point. The start position of the reaction area of the first cassette is detected, and a second time point is defined when a first light detecting signal greater than or equal to a predetermined value is obtained. After a predetermined time, a second light detecting signal is obtained from a color band of the reaction area. The time difference between the first time point and the second time point is calculated and the time difference is designated as a first retention time. A compensation value is obtained in a lookup table according to the first retention time and the second detecting signal and the second detecting signal is compensated by the compensation value.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 25, 2021
    Assignee: Delta Electronics, Inc.
    Inventors: Ying-Ting Chen, Peng-Hsiang Wu
  • Patent number: 10989727
    Abstract: An apparatus for cup loading and unloading and a thromboelastography machine are provided. The apparatus for cup loading and unloading includes a base, a shaft, a movable cover, and a cup holder. The shaft is rotatably connected to the base about an axis of the shaft and has an end configured to engage with an inner cup. The movable cover is disposed around the shaft and slidably connected to the base along the axis of the shaft. The movable cover is provided with an elastic member therein. The cup holder is slidably connected to the base along the axis of the shaft and disposed below the base and the shaft. The cup holder has a cavity configured to engage with an outer cup, and the cavity has an open directed upward.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: April 27, 2021
    Assignee: MEDCAPTAIN MEDICAL TECHNOLOGY CO., LTD
    Inventors: Zhiguang Yu, Shuai Yin, Lintao Wu, Jun Dong
  • Patent number: 10991744
    Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: April 27, 2021
    Inventors: Alan Marc Fine, Madhuranga Srinath Rankaduwa
  • Patent number: 10929974
    Abstract: Present invention relates to devices and methods for determining a calcium content by analyzing cardiac spectral CT data. CT projection data (9), obtainable by scanning a cardiac region of a subject using a spectral CT scanning unit, is modelled (12) by applying a material decomposition algorithm to the projection data to provide a calcium-specific component. Tomographic reconstructions (13) of the projection data, to provide a first 3D image (8), and of the calcium-specific component, to provide a second 3D image (6), are performed. The first 3D image (8) is segmented (14) to provide an image mask (5) corresponding to a cardiovascular structure of interest, a part of the second 3D image (6) is selected (15) based on the image mask (5), and a calcium content is calculated (16) in the cardiovascular structure of interest based on the selected part of the second 3D image (6).
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: February 23, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Dirk Schaefer, Heiner Daerr, Thomas Koehler, Ewald Roessl
  • Patent number: 10925534
    Abstract: The present invention relates to a skin measurement device capable of measuring information related to the skin. The skin measurement device capable of transmitting and receiving data to and from a skin treatment device, according to one embodiment of the present invention, comprises: a sensing unit formed so as to sense information related to the skin; and a control unit for controlling the sensing unit such that the sensing unit senses information related to certain skin, on the basis of contact between the skin measurement device and the certain skin, wherein the sensing unit is formed so as to emit light on the certain skin and to sense the information related to the certain skin on the basis of light reflected from the certain skin.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: February 23, 2021
    Assignee: LG ELECTRONICS INC.
    Inventors: Jungho Chung, Dongwon Kim
  • Patent number: 10925549
    Abstract: Devices, systems, and methods herein relate to predicting infection of a patient. These systems and methods may comprise illuminating a patient fluid in a fluid conduit from a plurality of illumination directions, measuring an optical characteristic of the illuminated patient fluid using one or more sensors, and predicting an infection state of the patient based at least in part on the measured optical characteristic.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: February 23, 2021
    Assignee: GASTROKLENZ INC.
    Inventors: Eric Hsiang Yu, Aly R. Elbadry, Carlos Rovira Borras, Daniel Elliott Francis
  • Patent number: 10914671
    Abstract: Flow cytometers having an enclosed particle sorting module are provided. Aspects of the flow cytometers include, in addition to the enclosed particle sorting modules, a sample input module fluidically coupled to an inlet of the enclosed particle sorting module, a waste reservoir fluidically coupled to first outlet of the enclosed particle sorting module and a first sorted particle collection system fluidically coupled to a second outlet of the enclosed particle sorting module. Flow cytometers as described herein are configured to control aerosol content in the enclosed particle sorting modules, including the sort chambers of such modules. Also provided are methods of using the flow cytometers, as well as kits that include one or more components of the flow cytometers are consumables for use therewith.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: February 9, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Pierce Norton, Kyle Dembski, Henry Lankila
  • Patent number: 10893829
    Abstract: A colorimetric optical sensor device includes a broadband light source configured to emit a light that is exposed to a fluid in a vessel. At least a portion of the light is reflected off of the fluid and received by an optical spectrometer. The optical spectrometer analyzes at least a portion of the received light to determine a main wavelength of the light. A controller correlates the main wavelength to a corresponding hematocrit or free hemoglobin concentration and generates an output indicative of the hematocrit or the free hemoglobin concentration of the fluid. The hematocrit or free hemoglobin concentration information may be used by a separation assembly in which the colorimetric optical sensor device may be incorporated to modify a separation procedure in which the monitored fluid is to be separated or is a component or constituent of a previously separated biological fluid.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 19, 2021
    Assignee: Fenwal, Inc.
    Inventors: Benjamin E. Kusters, Kyungyoon Min
  • Patent number: 10888804
    Abstract: The present invention relates to a method for separating and washing microparticles via a stratified co-flow of non-Newtonian fluid and Newtonian fluid, wherein the Newtonian fluid as well as the non-Newtonian fluid may flow into a transfer channel formed in a fluid chip at a predetermined flow rate ratio matching with an effective diameter of the target particles contained in the non-Newtonian fluid, thereby inducing a change in positions of particle focusing points with respect to the target particles within the stratified co-flow thereof formed in the transfer channel. As a result, it is possible to more easily separate only the target particles among the microparticles contained in the non-Newtonian fluid toward the Newtonian fluid without using an additional device and human power, or transfer the target particles contained in the non-Newtonian fluid toward the Newtonian fluid for washing the same.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 12, 2021
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Hyung-Jin Sung, Byung-Hang Ha
  • Patent number: 10876949
    Abstract: A flow device, method, and system are provided for determining the fluid particle composition. An example flow device includes a fluid sensor configured to monitor at least one particle characteristic of fluid flowing through the fluid sensor. The example flow device also includes at least one processor configured to, upon determining the at least one particle characteristic satisfies a particle criteria, generate a control signal for an external device. The example flow device also includes a fluid composition sensor configured to be powered based on the control signal and further configured to capture data relating to the fluid particle composition. The example flow device is also configured to generate one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: December 29, 2020
    Assignee: HONEYWELL INTERNATIONAL INC.
    Inventors: Andy Walker Brown, Adam D. McBrady, Ryadh Abdullah Zakaria, Stephan Michael Bork
  • Patent number: 10864056
    Abstract: An apparatus for detecting deformation of an elongate body may comprise a light source configured to sequentially provide light of multiple frequencies, an optical receiver configured to receive light from the light source, and a filter disposed between the light source and the optical detector. The filter may comprise multiple segments, each of the segments configured to filter light at one of the frequencies so as to alter the amount of light incident on said optical receiver. A total amount of light detected by the optical receiver may change during the sequence so as to be indicative of deformation of the elongate body.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: December 15, 2020
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventor: Gleb V. Klimovitch
  • Patent number: 10849537
    Abstract: A processing apparatus having a processor acquiring image data indicating oxygen saturation distribution inside an object by using signals derived from acoustic waves generated from a plurality of wavelengths of light. The processor acquires an oxygen saturation at a first position of a blood vessel of the object, generated by image reconstruction using signals, acquires a first correction amount to correct the oxygen saturation at the first position of the blood vessel, and acquires a second correction amount to correct the oxygen saturation in a second position of the object other than the first position, based on the first correction amount.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: December 1, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Nobuhito Suehira
  • Patent number: 10837914
    Abstract: An implement analyzing device that is sized for receiving more than one fluid retainer cartridge assembly is disclosed. The implement analyzing device includes a support member, a housing, a cartridge receiver, at least one cartridge heater, an imaging device and an implement analyzing device integrated circuit. The cartridge receiver is disposed within a cavity in the implement analyzing device and defines at least one cartridge viewing window. At least one cartridge heater disposed within the cavity and connected to the cartridge receiver. The imaging device is disposed within the cavity and arranged opposite the at least one cartridge viewing window. The implement analyzing device integrated circuit is communicatively coupled to the at least one cartridge heater and the imaging device.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: November 17, 2020
    Assignee: NEOGEN CORPORATION
    Inventors: Frank Eric Klein, Andrew John Wheeler, Andrew John DenHartigh, William Hoerner, Nathaniel Banner, Damon Borich, Andrea Grbavac, Alejandro Silveyra, Michelle Silveyra, Zwckxally Obregon
  • Patent number: 10835122
    Abstract: A method for image processing medical self-test results receives a digital image of a visual indication of a test result. A digital image is generated of the visual indication of the test result that includes noise and distortions therein. The digital image is processed using generalized curve field transforms to extract relevant features of the digital image in a presence of the noise and distortions to create a transformed image. A diagnosis is generated based upon the transformed image to the plurality of images of the test results.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: November 17, 2020
    Assignee: RELIANT IMMUNE DIAGNOSTICS, INC.
    Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III, Hans Kristian Sandberg
  • Patent number: 10830686
    Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: November 10, 2020
    Assignee: Abbott Laboratories
    Inventors: John F. Heanue, Stuart L. Friedman
  • Patent number: 10806385
    Abstract: The concentration of substance in blood is measured non-invasively, with high accuracy and with simple configuration. Laser light generated by a light source is locally irradiated on the body epithelium of a subject, and the resulting diffused reflected light is detected by a light detector. The laser light has a wavelength of 9.26 ?m. The laser light is generated by converting and amplifying pulsed excitation light from an excitation light source to a long wavelength. A plate-shaped window that is transparent to mid-infrared light is brought in close contact with the body epithelium. The glucose concentration in interstitial fluid can be calculated using normalized light intensity calculated from a signal ratio of signals from a monitoring light detector and light detector.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: October 20, 2020
    Assignee: National Institutes for Quantum and Radiological Science and Technology
    Inventor: Koichi Yamakawa
  • Patent number: 10799866
    Abstract: Provided is a microfluidic chip. A microfluidic chip includes a main body portion and a first plunger. The main body portion includes a first fluid space for containing a first fluid and a first micro flow channel that is in communication with the first fluid space. The first plunger is capable of movement in the first fluid space so as to deliver the first fluid from the first fluid space to the first micro flow channel. According to the first aspect, a first fluid space for containing a first fluid such as a testing solution and a first plunger that delivers the first fluid from the first fluid space are provided. That is, a syringe composed of the first fluid space and the first plunger is provided, and it is therefore possible to deliver the first fluid by operating the syringe.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: October 13, 2020
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Kentaro Fujimoto
  • Patent number: 10791970
    Abstract: Disclosed is a blood glucose measuring device, method, and system. In response to a connection of a blood glucose measuring module to a socket of the blood glucose measuring device being detected, the blood glucose measuring device may receive a data signal from the blood glucose measuring module and read a bit of the data signal based on a period of data signal.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: October 6, 2020
    Assignee: PHILOSYS CO., LTD.
    Inventor: Jung Yun Yang
  • Patent number: 10794814
    Abstract: The present disclosure includes provides methods for analyzing biological samples to identify, classify, and/or quantify platelets in the sample. The present disclosure also provides systems and methods for analyzing a blood sample to determine presence of platelet clumps in the sample. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: October 6, 2020
    Assignee: Abbott Laboratories
    Inventor: Martin Krockenberger
  • Patent number: 10782234
    Abstract: A composition for detecting a bloodstain includes: 3-aminophthalhydrazide; glycine; sodium hydroxide; and sodium phosphate dibasic heptahydrate.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 22, 2020
    Assignees: Korean National Police Agency, Republic of Korea(National Forensic Service Director Ministry of Interior and Safety)
    Inventors: Seung Lim, Si-Keun Lim
  • Patent number: 10782283
    Abstract: According to the present disclosure, a method of calculating a formation time of a perimeter stain is performed by a device for calculating a formation time of a perimeter stain, and includes obtaining a captured image of an analysis target by using a camera, extracting an image of a perimeter stain included in the analysis target, by analyzing the obtained captured image, calculating a major axis length and a width of the perimeter stain, estimating a formation time of the perimeter stain by using the major axis length and the width of the perimeter stain, and outputting the image of the perimeter stain and the formation time of the perimeter stain.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: September 22, 2020
    Assignee: Republic of Korea (National Forensic Service Director Ministry of Public Administration and Security)
    Inventors: Nam Kyu Park, Jae Mo Goh, Jin Pyo Kim, Young Il Seo, Eun Ah Joo, Je Hyun Lee, Sang Yoon Lee, Dong A Lim, Ki Hwan Kim
  • Patent number: 10782306
    Abstract: The invention relates to a method of determining a concentration of a substance in a cell suspension, said method comprising the following steps: —determining the concentration of the substance by: —using the results of absorption measurements performed at n local sample volumes contained at different average chamber heights of a chamber arrangement comprising the cell suspension and local substance concentration in said respective local sample volumes determined based on said respective absorption measurements; —using a substance concentration model comprising local substance concentration as a function of chamber height, and—determining the substance concentration as the infinite chamber height substance concentration using said substance concentration model and the determined local substance concentrations, wherein n is at least 2, such as at least 3, such as at least 4, wherein, optionally, the cell suspension is whole blood and the substance is Hb and wherein the method further comprises determining cRBC
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 22, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Niels Agersnap Larsen
  • Patent number: 10774359
    Abstract: Herein is provided a simple, reliable and accurate method for cellular analysis on hematology analyzers. In various aspects, the methods provide separation and/or differentiation between red blood cells (RBCs) and white blood cells (WBCs) by utilizing a fluorescent dye to selectively stain WBCs such that they emit stronger fluorescence signals. The method provides optimal detection limits on WBCs and RBCs, thereby allowing analysis of samples with sparse cellular concentrations. As few as one reagent may be used to prepare a single dilution for body fluid analysis, in order to simplify the body fluid analysis. Minimal damage to WBCs is attained using the lysis-free approach described in aspects of the disclosure.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: September 15, 2020
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Emily H. Lin, Jihping Yang
  • Patent number: 10751026
    Abstract: The object of the invention is a skeletal method utilizing electromagnetic waves to be utilized at least in one of skeletal actuation, skeletal detection and skeletal therapy. In the method is performed at least one of first and second method steps, where in the first method step is generated by means of electromagnetic waves at least one mechanical wave in at least one generation location into the skeleton through soft tissue. In the second method step is detected by means of electromagnetic waves skeletal vibrations due to at least one mechanical wave, is recorded the detected at least one mechanical wave in at least one recording location to form mechanical wave information, and distance of said at least one recording location from said at least one generation location is known, and further in the second method step is determined skeletal properties based on at least one recorded signal.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: August 25, 2020
    Assignee: OSCARE MEDICAL OY
    Inventors: Petro Moilanen, Jussi Timonen, Vantte Kilappa, Pasi Karppinen, Edward Haeggstrom, Timo Karppinen, Zuomin Zhao, Risto Myllyla
  • Patent number: 10746652
    Abstract: A hemoglobin sensor capable of quickly detecting occult blood of excreta in a toilet and a detecting method thereof are disclosed. The hemoglobin sensor includes a handheld housing and a result presentation unit. The housing includes a light emitting unit, an operating interface, a light sensing unit, and a data processor disposed therein. The operating interface is connected to the light emitting unit for activating the light emitting unit to emit a plurality of incident light beams having wavelengths in a range between 350 nm and 800 nm. The incident light beams penetrate a solution in a container having excreta and hit a light reflector of the container to produce at least one detection light beam. The light sensing unit receives the detection light beam and output a detection signal, and the data processor generates a detection result data after receiving the detection signal and analyzing it.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: August 18, 2020
    Assignee: REDEYE INC.
    Inventors: Shuo-Ting Yan, Kuan-Wei Su, I-Hua Wang, Chen-Chung Chang
  • Patent number: 10725017
    Abstract: The invention relates to a prognostic method of analyzing a biological sample from a cancer patient to predict his/her response to a specified modality of cancer treatment comprising the steps of: (a) performing spectroscopy on the biological sample to obtain a spectrum; (b) comparing the obtained spectrum with one or more spectra to calculate a probability of a response to the specified modality of cancer treatment by the cancer patient.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: July 28, 2020
    Assignee: Technological University Dublin
    Inventors: Fiona Lyng, Adrian Maguire, Aidan Meade, Isabel Vega Carrascal, Lisa White, Orla Howe
  • Patent number: 10722173
    Abstract: Methods for combining anatomical data and physiological data on a single image are provided. The methods include obtaining an image, for example, a raw near-infrared (NIR) image or a visible image, of a sample. The image of the sample includes anatomical structure of the sample. A physiologic map of blood flow and perfusion of the sample is obtained. The anatomical structure of the image and the physiologic map of the sample are combined into a single image of the sample. The single image of the sample displays anatomy and physiology of the sample in the single image in real time. Related systems and computer program products are also provided.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: July 28, 2020
    Assignee: East Carolina University
    Inventors: Cheng Chen, Thomas Bruce Ferguson, Jr., Kenneth Michael Jacobs, Zhiyong Peng
  • Patent number: 10710082
    Abstract: Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: July 14, 2020
    Assignee: PRESSURE BIOSCIENCES, INC.
    Inventors: Vera Gross, Edmund Y. Ting, Alexander Lazarev, Richard T. Schumacher
  • Patent number: 10697010
    Abstract: Disclosed herein are methods for single-cell sequencing. In some examples, the methods include enriching a sample comprising a plurality of cells for cells of interest to produce an enriched cell sample; isolating one or more cells of interest in the enriched cell sample; and obtaining sequence information of one or more polynucleotides from each of the one or more isolated cells. Obtaining sequence information may include generating a molecularly indexed polynucleotide library from the one or more isolated cells. Enriching the sample may include focusing cells of interest in the sample using acoustic focusing.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: June 30, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Clark Mason, Liping Yu
  • Patent number: 10656072
    Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: May 19, 2020
    Assignee: Kinetic River Corp.
    Inventor: Giacomo Vacca
  • Patent number: 10648936
    Abstract: There is provided a blood condition analyzing device including an erythrocyte quantitative evaluation unit configured to evaluate a hematocrit value and/or a hemoglobin amount on the basis of an electrical characteristic of a blood sample at a frequency of 2 to 25 MHz.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: May 12, 2020
    Assignee: Sony Corporation
    Inventors: Yoshihito Hayashi, Marcaurele Brun, Yoichi Katsumoto
  • Patent number: 10650221
    Abstract: The subject disclosure presents systems and methods for receiving a plurality of assay information along with a query for one or more features of interest, and projecting anatomical information from an anatomical assay onto a staining assay, for example an immunohistochemical (IHC) assay that is commonly registered with the anatomical assay, to locate or determine features appropriate for analysis. The anatomical information may be used to generate a mask that is projected on one or more commonly registered staining assays. A location of the feature of interest in the staining assay may be correlated with the anatomical context provided by the mask, with any features of interest that match the anatomical mask being selected or indicated as appropriate for analysis.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: May 12, 2020
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Srinivas Chukka, Anindya Sarkar, Joerg Bredno
  • Patent number: 10624543
    Abstract: A photo-acoustic sensing apparatus (100) for non-invasive measurement of blood parameters of a subject (102) comprises a photo-acoustic sensor (104) for sensing photo-acoustic signals (106) induced when a region of the subject is illuminated by a light source (108). A first sensor processing module (112) may derive blood oxygen saturation using sensed photo-acoustic signals (114). A second sensor processing module (116) may derive blood core temperature using sensed photo-acoustic signals. A third sensor processing module (118) may derive blood glucose using sensed photo-acoustic signals. The sensing apparatus is configured to derive at least one of: a de-correlated value (120) of blood oxygen saturation of the subject; a de-correlated value (122) of blood core temperature of the subject; and a de-correlated value (124) of blood glucose of the subject.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: April 21, 2020
    Assignee: Nanyang Technological University
    Inventors: Yuanjin Zheng, Xiaohua Feng, Fei Gao
  • Patent number: 10623627
    Abstract: The present invention relates to a system for generating a synthetic 2D image with an enhanced depth of field of a biological sample. It is described to acquire (110) with a microscope-scanner (20) first image data at a first lateral position of the biological sample and second image data at a second lateral position of the biological sample. The microscope-scanner is used to acquire (120) third image data at the first lateral position and fourth image data at the second lateral position, wherein the third image data is acquired at a depth that is different than that for the first image data and the fourth image data is acquired at a depth that is different than that for the second image data. First working image data is generated (130) for the first lateral position, the generation comprising processing the first image data and the third image data by a focus stacking algorithm.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 14, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jelte Peter Vink, Bas Hulsken, Martijn Wolters, Marinus Bastiaan Van Leeuwen, Stuart Hamish Shand
  • Patent number: 10620111
    Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: April 14, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin
  • Patent number: 10588577
    Abstract: Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, the framework performs affine template matching of a region of interest from patient signal data with a baseline signal portion by performing an affine waveform transformation of the region of interest. One or more affine ratios may be determined based on the matched region of interest and the baseline signal portion for generating a report or diagnosis of a cardiac event.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: March 17, 2020
    Assignee: Siemens Healthcare GmbH
    Inventor: Hongxuan Zhang
  • Patent number: 10575766
    Abstract: [Object] To measure a form of light scattering in a body more simply. [Solution] A measurement device according to the present disclosure includes: a light source configured to emit at least one kind of measurement light belonging to a predetermined wavelength band toward a measurement region formed by at least a part of a living body; a detection unit configured such that a plurality of sensors are arranged regularly in a predetermined disposition and the measurement light emitted from the light source and transmitted through the living body is detected by the plurality of sensors; and an analysis unit configured to analyze at least one of rectilinearity of the measurement light in the living body and an optical distance from the light source using a detection result of the measurement light detected by the detection unit.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: March 3, 2020
    Assignee: Sony Corporation
    Inventor: Hideo Sato
  • Patent number: 10571391
    Abstract: The present application relates to a method for adjusting a measuring device for measuring a measurand of a medium using at least one measuring sensor, including: laboratory calibration of the measuring device in a calibration solution, laboratory calibration of the measuring device in air, determination of a correction factor for correcting the laboratory calibration value of the measuring device in air to the laboratory calibration value of the measuring device in the calibration solution, on-site calibration of the measuring device in air, using the correction factor to correct the on-site calibration value of the measuring device in air, and on-site adjustment of the measuring device using the corrected on-site calibration value.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: February 25, 2020
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Frank Müller, Peter Lindmüller, Daniel Iten
  • Patent number: 10561348
    Abstract: A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: February 18, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Yun S Park, Sang Kon Bae, So Young Lee
  • Patent number: 10555693
    Abstract: Disclosed in an embodiment is an operating method of portable apparatus for noninvasively measuring blood glucose levels. The method includes: (a) measuring a first signal value according to ambient environmental light when an LED for measuring signals which emits light with wavelengths to be absorbed into or scattered by glucose is switched off; (b) measuring a second signal value according to light which is scattered by or transmitted through subject tissue and enters a photodetecting unit when the LED for measuring signals is switched on; (c) calculating a glucose concentration measurement of a subject by using the first signal value and the second signal value; and (d) adjusting the quantity of the light radiated from the LED for measuring signals by feeding the difference between the glucose concentration measurement and a pre-established first reference value back to the driving current for the LED for measuring signals.
    Type: Grant
    Filed: February 12, 2017
    Date of Patent: February 11, 2020
    Inventor: Hoon Kim