Blood Analysis Patents (Class 356/39)
  • Patent number: 11577994
    Abstract: The present invention is a method for manufacturing an optical fiber which includes a resin coating step in which a resin is supplied to a resin coating section via piping, and a glass fiber is passed through the resin coating section such that the resin is coated on the outer circumference of the glass fiber. In the resin coating step, the temperature of the resin inside the piping is measured, and a heating unit provided on the outer circumference of at least some of the piping is controlled such that the temperature of the resin inside the piping reaches a set target temperature; and a viscometer is disposed in between the resin coating section and the piping on which the heating unit is provided, and the set value of the target temperature is adjusted such that the viscosity of the resin measured by the viscometer reaches a target viscosity.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: February 14, 2023
    Assignee: SUMITOMO ELECTRIC INDUSTRIES, LTD.
    Inventor: Nao Yoshida
  • Patent number: 11525766
    Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: December 13, 2022
    Assignee: Iris International, Inc.
    Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
  • Patent number: 11513061
    Abstract: A device for monitoring at least one parameter of a fluid specimen obtained from a patient. The device has a fluid conduit holder comprising a clamp configured to position a fluid conduit, which holds the fluid specimen obtained from the patient, in a position for optical analysis, and an optical analyzer having a light source and a light detector. The optical analyzer is configured to expose the fluid specimen contained within the fluid conduit to an illuminant and measure light received at the detector. The device has an optical alignment mechanism mechanically coupling the light source, the clamp, and the light detector together, and configured to align at least the light detector with the fluid conduit at the position for optical analysis.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: November 29, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Michael T. McCurdy, Rajagopal Srinivasan
  • Patent number: 11504070
    Abstract: A method of estimating concentration of a blood compound may include: removing a baseline drift from Near-Infrared (NIR) spectroscopy data to obtain drift-free spectral features; obtaining a set of global features based on the drift-free spectral features; and estimating the concentration of the blood compound by regression using the set of global features.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: November 22, 2022
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sujit Jos, Srikanth Mallavarapu Rama, Kiran Bynam, So Young Lee, Gorish Aggarwal
  • Patent number: 11504834
    Abstract: An actuation system for preventing actuation of a base device upon a non-target substrate. The actuation system includes a detector configured to generate and transmit a profile signal of a test substrate. A processing unit is in communication with the detector and configured to receive the profile signal of the test substrate from the detector, the processing unit being configured to determine whether the profile signal of the test substrate corresponds to a profile signal of a target substrate, and to generate an actuation signal if the profile signal of the test substrate corresponds to the profile signal of the target substrate. An actuation unit is in communication with the processing unit and the base device, the actuation unit being configured to receive the actuation signal from the processing unit and to permit the base device to actuate when receiving the actuation signal.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: November 22, 2022
    Assignee: Marquette University
    Inventors: Mark L. Nagurka, Richard W. Marklin, Jr.
  • Patent number: 11504037
    Abstract: Systems and methods for assessing fluids from a patient are disclosed. The system includes a receptacle including an inlet port, an outlet port, and a third port; a valve system in fluidic communication with the receptacle; and one or more features in the receptacle to aid in optical imaging of fluids. The system has a fill mode and a flush mode. In the fill mode, the valve system directs suction from a vacuum source through the third port into the receptacle, thereby drawing fluid through the inlet port into the receptacle. In the flush mode, the valve system directs suction from the vacuum source through the outlet port, thereby drawing fluid through the outlet port out of the receptacle. Fluid-related information such as, for example, concentration of a blood component, may be estimated based on images of fluids in the receptacle.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: November 22, 2022
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Peter Hyoung, Kevin Miller, Andrew Hosford, Eric Hsieh
  • Patent number: 11439328
    Abstract: An optical sensor according to an example embodiment includes: a light source part configured to emit light onto an object; a signal separator configured to separate optical signals, returning from the object, into a fluorescence signal and a non-fluorescence signal; a first photodetector part configured to detect the non-fluorescence signal; and a second photodetector part configured to detect the fluorescence signal.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: September 13, 2022
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: Moonseong Park
  • Patent number: 11428550
    Abstract: A system may include a first sensor of a first type and a second sensor of a second different type and having a detector. A field of view of the second sensor may be formed by a plurality of regions of interest (ROIs) defined by the detector. Control circuitry of the system may be configured to perform operations including obtaining, from the first sensor, first sensor data representing an environment, and determining, based on the first sensor data, information associated with a feature of interest within the environment. The operations may also include determining, based on the information, a particular ROI that corresponds to an expected position of the feature at a later time, obtaining a plurality of ROI sensor data from the particular ROI instead of obtaining full-resolution sensor data, and analyzing the plurality of ROI sensor data to determine one or more attributes of the feature.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: August 30, 2022
    Assignee: Waymo LLC
    Inventors: Nirav Dharia, Giulia Guidi, Ralph Shepard, Vlad Cardei, Lucian Ion
  • Patent number: 11408813
    Abstract: In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: August 9, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: George C. Malachowski, Paul Barclay Purcell, Edward Allan Stanton, Kenneth Michael Evans
  • Patent number: 11406302
    Abstract: An oxygen measurement device constituting an oxygen measurement system includes a urethral catheter and an oxygen sensor main body. The urethral catheter has a shaft in which a urethral catheter lumen that enables circulation of urine flowed in via a urethral catheter port from inside a bladder is formed; and has a hub in which a urine lumen that is provided at a proximal end of the shaft and communicates with the urethral catheter lumen is formed. The oxygen sensor main body is provided on the hub in a manner capable of being brought into contact with urine circulating in the urine lumen, and detects oxygen in the urine.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: August 9, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Satoru Suehara, Akihiro Takahashi
  • Patent number: 11372006
    Abstract: An apparatus for determining the mean corpuscular haemoglobin concentration (MCHC) in a whole blood sample includes a sample holder including an elongate sample chamber having an open end and a closed end. A holding member is adapted to receive and retain the sample holder. The holding member rotates may rotate about an axis of rotation. When the sample holder is received and retained by the holding member the sample chamber is substantially perpendicular to the axis of rotation. First and second light sources are positioned on one side of the sample holder and are configured to emit light in respective different frequencies. At least one light sensor is positioned on a second side of the sample holder, opposite from the first side, so that light from the light source may pass through the sample chamber, in at least one rotational position of the sample holder, and impinge on the light sensor.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: June 28, 2022
    Assignee: Entia Ltd.
    Inventors: Toby Basey-Fisher, Christopher Burrows
  • Patent number: 11350837
    Abstract: Methods and systems of optically measuring systolic and/or diastolic blood pressure of a mammal having biological tissue are disclosed herein. In some embodiments, the system comprises an optical blood motion sensor, a gas-sealable inflatable cushion having a flexible and transparent (FOT) barrier section, and an optical blood motion sensor comprising a laser. When pressure (e.g. at least systolic pressure) illuminates the tissue, laser light may pass en route to the tissue through the FOT sealing barrier section of the gas-sealable inflatable cushion as well as cushion interior. In some embodiments, a rigid restrictor comprising an optically transparent section is provided, and laser light also passes through the optically transparent section of the rigid restrictor en route to the biological tissue.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: June 7, 2022
    Assignee: ELFI-TECH LTD.
    Inventors: Ilya Fine, Alexander Kaminsky
  • Patent number: 11340155
    Abstract: A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. The container may comprise an elongate axis and the container configured for placement in the spectrometer receptacle with the elongate axis extending toward a vertical direction in order to improve gravimetric separation of the blood sample. The spectrometer can be configured to measure the blood sample at a plurality of heights along the sample as the sample separates.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 24, 2022
    Assignee: NUEON INC.
    Inventor: Robert G. Messerschmidt
  • Patent number: 11331011
    Abstract: A system, for the transcutaneous measurement of a substance concentration, preferably alcohol, in blood, includes a light source (1); a detector device (15); an optical device (7, 7?), with an inlet (5), an outlet (49) and an exit opening (35); and a contact surface element (37) with a contact surface (41). Measuring radiation emitted by the light source (1) reaches the inlet (5) and exits the exit opening (35), to the contact surface (41). The optical device (7, 7?) focuses measuring radiation at a measuring point (39) at a predefined distance from the contact surface (41). The optical device (7, 7?) is configured such that scattered radiation generated in the measuring point (39) and entering into the exit opening (35) is focused at an outlet point (19) at the outlet (49). The detector device (15) is arranged to detect the scattered radiation focused at the outlet point (19).
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: May 17, 2022
    Assignee: Dräger Safety AG & Co. KGaA
    Inventors: Stefan Morley, Arne Tröllsch, Livio Fornasiero
  • Patent number: 11331052
    Abstract: Devices, systems, and methods herein relate to predicting infection of a patient. These systems and methods may comprise illuminating a patient fluid in a fluid conduit from a plurality of illumination directions, measuring an optical characteristic of the illuminated patient fluid using one or more sensors, and predicting an infection state of the patient based at least in part on the measured optical characteristic.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: May 17, 2022
    Assignee: GASTROKLENZ INC.
    Inventors: Eric Hsiang Yu, Aly R. Elbadry, Carlos Rovira Borras, Daniel Elliott Francis
  • Patent number: 11324292
    Abstract: A ring-type wearable device is disclosed. The disclosed ring-type wearable device comprises: an outer ring member; an inner ring member separably inserted into the outer ring member; a sensor unit disposed in the outer ring member; and a control unit disposed in the outer ring member so as to be electrically connected to the sensor unit, wherein the sensor unit can maintain constant sensitivity in correspondence to the thickness of the inner ring member.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: May 10, 2022
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jin-hong Min, Jea-hyuck Lee, Seong-wook Jo, Shin-hee Cho, Su-ho Lee
  • Patent number: 11324563
    Abstract: Protective coverings are provided for hand-held medical devices that have a measuring port for a disposable analytical test element. The coverings also include a sleeve having a reception opening and can be slipped over the devices to at least partially enclose the devices in a usable protected state. The coverings further include a test element adapter formed as an integral part of the sleeve to receive the test element in alignment with a measuring port, where the sleeve includes the test element adapter and is arranged as a sealing barrier between the test element and the device port in a protected state.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: May 10, 2022
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Herbert Harttig, Sebastian Liedtke, Matthias Mock
  • Patent number: 11314075
    Abstract: An image processing device is configured to: generate a histogram of pixel values of a plurality of pixels contained in an image; set a background pixel value by using a peak value of the generated histogram; set a noise range with respect to the set background pixel value; and replace the pixel values that fall in the set noise range with a single arbitrary pixel value.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: April 26, 2022
    Assignee: OLYMPUS CORPORATION
    Inventors: Masahito Dohi, Motohiro Shibata
  • Patent number: 11309078
    Abstract: The present disclosure includes methods, devices and systems for establishing a connection between a medical device and a remote computing device, receiving an upgrade command at the medical device, storing a current version of persistent data and a current version of executable code in a first storage area of the medical device, transmitting at least the current version of the persistent data to the remote computing device, receiving a second format of the current version of the persistent data and an upgraded version of executable code at the medical device, storing the second format of the current version of the persistent data and the upgraded version of the executable code in a second storage area of the medical device, and executing the upgraded version of the executable code with the second format of the current version of the persistent data.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: April 19, 2022
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Saeed Nekoomaram, Nathan C. Crouther
  • Patent number: 11287367
    Abstract: A method and system is described that includes obtaining a whole blood sample and obtaining a first light absorbance profile of the whole blood sample. Next, the whole blood sample is hemolyzed to generate a hemolyzed sample of blood and a second light absorbance profile of the hemolyzed sample of blood is obtained. The level of hemolysis in the whole blood sample is determined by comparing the first light absorbance profile and the second light absorbance profile.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: March 29, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jeffrey Jasperse
  • Patent number: 11287364
    Abstract: A flow cytometer including a laser beam that impinges upon a sample stream at an angle at 15-70°, optionally 30°, from C an orthogonal plane where the light and fluid intercept.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: March 29, 2022
    Inventor: Gerrit Jan Van Den Engh
  • Patent number: 11248994
    Abstract: Disclosed are devices and methods for analyzing an analyte, such as white blood cells in liquid samples.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: February 15, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Chou, Wei Ding, Ji Qi
  • Patent number: 11234361
    Abstract: The invention relates to a system and method for determining a status of plants. The system includes a light transmitter arranged for providing broad band illumination to one or more plants. The system includes a light receiver including a plurality of receiver channels, the receiver channels arranged for receiving light from said one or more plants in mutually different wavelength bands. The system includes a processing unit arranged for determining a status of said one or more plants on the basis of light received by the plurality of receiver channels. The transmitter may be arranged for transmitting bursts of modulated light.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: February 1, 2022
    Assignee: YARA INTERNATIONAL ASA
    Inventors: Stefan Reusch, Lars Wuntke, Daniel Stephan, Christoph Mattolat
  • Patent number: 11232565
    Abstract: The present invention relates to an examining device (1) for processing and analyzing an image of a bio sample, an examining method for processing and analyzing an image of a bio sample, a computer program element for controlling such device (1), and a corresponding computer readable medium. The examining device (1) for processing and analyzing an image of a bio sample comprises an interface unit, an image analyzing unit, and a display unit. The interface unit is configured to provide an image of a bio sample. The image analyzing unit is configured to indicate a region of interest in the image as reference region, to extract a characteristic of the reference region from the image and to analyze the image for alternative regions with a similar characteristic. The display unit is configured to display the result of the analysis for alternative regions with a similar characteristic.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: January 25, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Marinus Bastiaan Van Leeuwen, Jelte Peter Vink
  • Patent number: 11217009
    Abstract: Paired images of substantially the same scene are captured with the same freestanding sensor. The paired images include reflected light illuminated with controlled polarization states that are different between the paired images. Information from the images is applied to a convolutional neural network (CNN) configured to derive a spatially varying bi-directional reflectance distribution function (SVBRDF) for objects in the paired images. Alternatively, the sensor is fixed and oriented to capture images of an object of interest in the scene while a light source traverses a path that intersects the sensor's field of view. Information from the paired images of the scene and from the images captured of the object of interest when the light source traverses the field of view are applied to a CNN to derive a SVBDRF for the object of interest. The image information and the SVBRDF are used to render a representation with artificial lighting conditions.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: January 4, 2022
    Assignee: Photopotech LLC
    Inventor: Benjamin von Cramon
  • Patent number: 11189027
    Abstract: Disclosed subject matter relates to Peripheral Blood Smear (PBS) that determines an area to be scanned in PBS for analysis. A PBS analysing system captures a focused image at each of plurality of positions in the PBS and determines Quality Indicators (QIs) in focused image. Further, a region is identified in PBS where QIs of focused image satisfy predefined QI threshold limits, as a monolayer region of PBS and determines an initiation point in monolayer region based on cell count value and co-ordinates of each of the plurality of positions located in the monolayer region. Finally, the area to be scanned in monolayer region is determined based on the initiation point and a predefined scan pattern. Determining the area to be scanned yields accurate and faster results.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 30, 2021
    Assignee: Sigtuple Technologies Private Limited
    Inventors: Shreepad Potadar, Dheeraj Mundhra, Abhishek Shukla, Raghu G, Amrutha Muralidharan, Deepak Kapoor, Vijay Muralidharan, Nivedita Muthusubramanian, Bharath Cheluvaraju, Apurv Anand, Tathagato Rai Dastidar, Rohit Kumar Pandey
  • Patent number: 11187644
    Abstract: The present disclosure relates to a method and system for determining Total Count (TC) of RBCs in a Peripheral Blood Smear (PBS). The system receives a plurality of images from the monolayer of the PBS. Further, the system extracts, segments and identifies RBCs in each of the plurality of images using deep learning models. The system computes a value of each variable of a set of variables for each of the plurality of images. The set of variables includes foreground non-pallor area, density of RBCs, cell count, cell count ratio, foreground area and foreground hole-filled area. Furthermore, the system computes statistical parameters for each variable, over the plurality of images. The statistical parameters are provided as an input to supervised learning model, to determine TC of RBCs. Thus, the TC estimation system provides an efficient and robust method for estimating TC of RBCs using plurality of images of the PBS.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 30, 2021
    Assignee: Sigtuple Technologies Private Limited
    Inventors: Dheeraj Mundhra, Himanshu Sharma, Shreepad Potadar, Bharath Cheluvaraju, Tathagato Rai Dastidar
  • Patent number: 11175303
    Abstract: A sample collection and testing device for analyzing blood is provided that includes a controller, a fluid flow pathway, a pump configured to move fluid through the fluid pathway, and an optical fluid measurement element configured to measure a light intensity of the fluid in the fluid flow pathway. The controller is configured to: start the pump to move a blood sample in the fluid flow pathway, receive a signal from the optical fluid measurement element indicating a detection of a leading edge of the blood in the fluid flow pathway, stop the pump to stop the moving of the blood in the pathway, receive a plurality of light intensity measurements from the optical measurement element, each light intensity measurement measured at a corresponding point of time, and provide a mapping of the light intensity measurements into an indication of a coagulation of the blood sample over a time period.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: November 16, 2021
    Assignee: 2Pi-Sigma Corp.
    Inventor: Mehdi Hatamian
  • Patent number: 11169092
    Abstract: A sample observation device includes an irradiation unit that irradiates a sample with planar light, a scanning unit that scans the sample in one direction with respect to an irradiation surface of the planar light, an image formation unit that forms images of fluorescent light and scattered light from the sample, an imaging unit that outputs first image data based on a light image of the fluorescent light and second image data based on a light image of the scattered light, an image processing unit that generates a fluorescent light image on the basis of a plurality of pieces of first image data and generates a scattered light image on the basis of a plurality of pieces of second image data, and an analysis unit that specifies an area in which there is the sample in the fluorescent light image on the basis of the scattered light image, and sets an analysis area in the fluorescent light image on the basis of the area in which there is the sample.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: November 9, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Norikazu Sugiyama, Masanori Matsubara, Satoshi Yamamoto
  • Patent number: 11141075
    Abstract: An integrated circuit device includes an insulating body provided with a number of electrically conductive leads and having a surface provided with a red LED aperture, an IR LED aperture and a photodetector aperture. The insulating body also includes an optical isolator optically separating the photodetector aperture from the red LED aperture and the IR LED aperture. A red LED is aligned with the red LED aperture, an IR LED is aligned with the IR LED aperture, and a photodetector is aligned with the photodetector aperture.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 12, 2021
    Assignee: Maxim Integrated Products, Inc.
    Inventors: Arpit Mehta, Richard I. Olsen, Daniel S. Christman
  • Patent number: 11137338
    Abstract: [Object] To provide an information processing apparatus, a particle sorting system, a program, and a particle sorting method that practice a spectral type analysis usable for sorting particles. [Solving Means] The information processing apparatus according to an aspect of the present technology includes: an analysis unit; a learning unit; and a discrimination unit. The analysis unit calculates fluorophore information indicating respective amounts of luminescence of a plurality of types of fluorophores on the basis of detection data indicating amounts of luminescence of fluorescence at respective wavelength bands, the fluorescence having been emitted from a particle irradiated with excitation light, discriminates whether or not to treat the particle as a process target in accordance with the fluorophore information, and generates teaching data by associating a result of the discrimination with the detection data.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 5, 2021
    Assignee: Sony Corporation
    Inventors: Kenji Yamane, Shigeatsu Yoshioka, Yasunobu Kato
  • Patent number: 11134901
    Abstract: Methods and systems of optically measuring systolic and/or diastolic blood pressure of a mammal having biological tissue are disclosed herein. In some embodiments, the system comprises an optical blood motion sensor, a gas-sealable inflatable cushion having a flexible and transparent (FOT) barrier section, and an optical blood motion sensor comprising a laser. When pressure (e.g. at least systolic pressure) illuminates the tissue, laser light may pass en route to the tissue through the FOT sealing barrier section of the gas-sealable inflatable cushion as well as cushion interior. In some embodiments, a rigid restrictor comprising an optically transparent section is provided, and laser light also passes through the optically transparent section of the rigid restrictor en route to the biological tissue.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 5, 2021
    Assignee: ELFI-TECH LTD.
    Inventors: Ilya Fine, Alexander Kaminsky
  • Patent number: 11105728
    Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: August 31, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Eric D. Diebold, Keegan Owsley, Jonathan Lin
  • Patent number: 11060967
    Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: July 13, 2021
    Assignee: NUEON INC.
    Inventors: Robert G. Messerschmidt, Howland D. T. Jones
  • Patent number: 11049249
    Abstract: A method, an apparatus and a system for cell detection are provided. In the apparatus, a hyperspectrum module is used to capture information across electromagnetic spectrums from an image, a stereo camera module is used to capture three-dimensional image information, and the hyperspectrum module and the stereo camera module form a trinocular micro spectrometer. A microscopic optical module is provided for the two modules to form hyperspectrum and three-dimensional image information from a cell and its split cells via a lens. In the method, a series of continuous images are obtained within a time period. An observation image array with a plurality of observation image zones are provided to retrieve coordinates of a plurality of feature points at different times. Finally, a holistic cellular activity can be obtained by analyzing continuous hyperspectrum and 3D image information from the images over time.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: June 29, 2021
    Assignees: PROVIDENCE UNIVERSITY, NATIONAL TSING HUA UNIVERSITY
    Inventors: Wei-Chung Wang, Yung-Hsiang Chen, Chuan-Yi Tang, Ching-Huan Kuo
  • Patent number: 11047798
    Abstract: A specimen containing a substance to be measured is introduced into a flow path of a measurement chip including a flow path which is a cavity for accommodating liquid and a reflecting unit which specularly reflects light which passes through the flow path so as to pass through the flow path again and a measurement value indicating an amount of the substance to be measured in the specimen is acquired. Then, second light acquired when first light including light of a wavelength absorbed by a red blood cell passes through the specimen in the flow path, is reflected by the reflecting unit, and passes through the specimen in the flow path again is detected in a state in which the specimen is present in the flow path. Next, a hematocrit value of the specimen is determined on the basis of a detection result of the second light. Next, a measurement value is corrected on the basis of the hematocrit value.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: June 29, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Fumio Nagai, Tetsuya Noda, Hideyuki Fujii
  • Patent number: 11039793
    Abstract: There is provided a method and apparatus for calibrating measurements made using a medical monitoring device. A conversion factor may be obtained including a first cross correlation that describes the correlation between measurements made using a first medical monitoring device and measurements made using a second medical monitoring device. The first conversion factor may then be used to convert measurements from the first medical monitoring device onto the same scale as measurements from the second medical monitoring device.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: June 22, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Meru Adagouda Patil, Nagaraju Bussa, Prasad Raghotham Venkat
  • Patent number: 11035778
    Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: June 15, 2021
    Assignee: Kinetic River Corp.
    Inventor: Giacomo Vacca
  • Patent number: 11016030
    Abstract: A detection method with a compensation function includes the following steps. After a sample is added to a first cassette, a first triggering instruction is provided to define a first time point. The start position of the reaction area of the first cassette is detected, and a second time point is defined when a first light detecting signal greater than or equal to a predetermined value is obtained. After a predetermined time, a second light detecting signal is obtained from a color band of the reaction area. The time difference between the first time point and the second time point is calculated and the time difference is designated as a first retention time. A compensation value is obtained in a lookup table according to the first retention time and the second detecting signal and the second detecting signal is compensated by the compensation value.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 25, 2021
    Assignee: Delta Electronics, Inc.
    Inventors: Ying-Ting Chen, Peng-Hsiang Wu
  • Patent number: 11013460
    Abstract: A system for noninvasively measuring blood alcohol concentration using light includes one or more emitters each configured to emit light in the near infrared or infrared light spectrum at one or more wavelengths that respond to varied chromophore concentrations of ethanol and water in blood of a human subject. One or more detectors is configured to detect light emitted at the one or more wavelengths and output a representation of a photoplethysmography (PPG) waveform for one or more of the one or more wavelengths. A processing subsystem is coupled to the one or more emitters and the one or more detectors.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: May 25, 2021
    Assignee: Vivonics, Inc.
    Inventor: Ryan Myers
  • Patent number: 10991744
    Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: April 27, 2021
    Inventors: Alan Marc Fine, Madhuranga Srinath Rankaduwa
  • Patent number: 10989727
    Abstract: An apparatus for cup loading and unloading and a thromboelastography machine are provided. The apparatus for cup loading and unloading includes a base, a shaft, a movable cover, and a cup holder. The shaft is rotatably connected to the base about an axis of the shaft and has an end configured to engage with an inner cup. The movable cover is disposed around the shaft and slidably connected to the base along the axis of the shaft. The movable cover is provided with an elastic member therein. The cup holder is slidably connected to the base along the axis of the shaft and disposed below the base and the shaft. The cup holder has a cavity configured to engage with an outer cup, and the cavity has an open directed upward.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: April 27, 2021
    Assignee: MEDCAPTAIN MEDICAL TECHNOLOGY CO., LTD
    Inventors: Zhiguang Yu, Shuai Yin, Lintao Wu, Jun Dong
  • Patent number: 10925534
    Abstract: The present invention relates to a skin measurement device capable of measuring information related to the skin. The skin measurement device capable of transmitting and receiving data to and from a skin treatment device, according to one embodiment of the present invention, comprises: a sensing unit formed so as to sense information related to the skin; and a control unit for controlling the sensing unit such that the sensing unit senses information related to certain skin, on the basis of contact between the skin measurement device and the certain skin, wherein the sensing unit is formed so as to emit light on the certain skin and to sense the information related to the certain skin on the basis of light reflected from the certain skin.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: February 23, 2021
    Assignee: LG ELECTRONICS INC.
    Inventors: Jungho Chung, Dongwon Kim
  • Patent number: 10925549
    Abstract: Devices, systems, and methods herein relate to predicting infection of a patient. These systems and methods may comprise illuminating a patient fluid in a fluid conduit from a plurality of illumination directions, measuring an optical characteristic of the illuminated patient fluid using one or more sensors, and predicting an infection state of the patient based at least in part on the measured optical characteristic.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: February 23, 2021
    Assignee: GASTROKLENZ INC.
    Inventors: Eric Hsiang Yu, Aly R. Elbadry, Carlos Rovira Borras, Daniel Elliott Francis
  • Patent number: 10929974
    Abstract: Present invention relates to devices and methods for determining a calcium content by analyzing cardiac spectral CT data. CT projection data (9), obtainable by scanning a cardiac region of a subject using a spectral CT scanning unit, is modelled (12) by applying a material decomposition algorithm to the projection data to provide a calcium-specific component. Tomographic reconstructions (13) of the projection data, to provide a first 3D image (8), and of the calcium-specific component, to provide a second 3D image (6), are performed. The first 3D image (8) is segmented (14) to provide an image mask (5) corresponding to a cardiovascular structure of interest, a part of the second 3D image (6) is selected (15) based on the image mask (5), and a calcium content is calculated (16) in the cardiovascular structure of interest based on the selected part of the second 3D image (6).
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: February 23, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Dirk Schaefer, Heiner Daerr, Thomas Koehler, Ewald Roessl
  • Patent number: 10914671
    Abstract: Flow cytometers having an enclosed particle sorting module are provided. Aspects of the flow cytometers include, in addition to the enclosed particle sorting modules, a sample input module fluidically coupled to an inlet of the enclosed particle sorting module, a waste reservoir fluidically coupled to first outlet of the enclosed particle sorting module and a first sorted particle collection system fluidically coupled to a second outlet of the enclosed particle sorting module. Flow cytometers as described herein are configured to control aerosol content in the enclosed particle sorting modules, including the sort chambers of such modules. Also provided are methods of using the flow cytometers, as well as kits that include one or more components of the flow cytometers are consumables for use therewith.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: February 9, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Pierce Norton, Kyle Dembski, Henry Lankila
  • Patent number: 10893829
    Abstract: A colorimetric optical sensor device includes a broadband light source configured to emit a light that is exposed to a fluid in a vessel. At least a portion of the light is reflected off of the fluid and received by an optical spectrometer. The optical spectrometer analyzes at least a portion of the received light to determine a main wavelength of the light. A controller correlates the main wavelength to a corresponding hematocrit or free hemoglobin concentration and generates an output indicative of the hematocrit or the free hemoglobin concentration of the fluid. The hematocrit or free hemoglobin concentration information may be used by a separation assembly in which the colorimetric optical sensor device may be incorporated to modify a separation procedure in which the monitored fluid is to be separated or is a component or constituent of a previously separated biological fluid.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 19, 2021
    Assignee: Fenwal, Inc.
    Inventors: Benjamin E. Kusters, Kyungyoon Min
  • Patent number: 10888804
    Abstract: The present invention relates to a method for separating and washing microparticles via a stratified co-flow of non-Newtonian fluid and Newtonian fluid, wherein the Newtonian fluid as well as the non-Newtonian fluid may flow into a transfer channel formed in a fluid chip at a predetermined flow rate ratio matching with an effective diameter of the target particles contained in the non-Newtonian fluid, thereby inducing a change in positions of particle focusing points with respect to the target particles within the stratified co-flow thereof formed in the transfer channel. As a result, it is possible to more easily separate only the target particles among the microparticles contained in the non-Newtonian fluid toward the Newtonian fluid without using an additional device and human power, or transfer the target particles contained in the non-Newtonian fluid toward the Newtonian fluid for washing the same.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 12, 2021
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Hyung-Jin Sung, Byung-Hang Ha
  • Patent number: 10876949
    Abstract: A flow device, method, and system are provided for determining the fluid particle composition. An example flow device includes a fluid sensor configured to monitor at least one particle characteristic of fluid flowing through the fluid sensor. The example flow device also includes at least one processor configured to, upon determining the at least one particle characteristic satisfies a particle criteria, generate a control signal for an external device. The example flow device also includes a fluid composition sensor configured to be powered based on the control signal and further configured to capture data relating to the fluid particle composition. The example flow device is also configured to generate one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: December 29, 2020
    Assignee: HONEYWELL INTERNATIONAL INC.
    Inventors: Andy Walker Brown, Adam D. McBrady, Ryadh Abdullah Zakaria, Stephan Michael Bork
  • Patent number: 10864056
    Abstract: An apparatus for detecting deformation of an elongate body may comprise a light source configured to sequentially provide light of multiple frequencies, an optical receiver configured to receive light from the light source, and a filter disposed between the light source and the optical detector. The filter may comprise multiple segments, each of the segments configured to filter light at one of the frequencies so as to alter the amount of light incident on said optical receiver. A total amount of light detected by the optical receiver may change during the sequence so as to be indicative of deformation of the elongate body.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: December 15, 2020
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventor: Gleb V. Klimovitch