Blood Analysis Patents (Class 356/39)
  • Patent number: 10656072
    Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: May 19, 2020
    Assignee: Kinetic River Corp.
    Inventor: Giacomo Vacca
  • Patent number: 10650221
    Abstract: The subject disclosure presents systems and methods for receiving a plurality of assay information along with a query for one or more features of interest, and projecting anatomical information from an anatomical assay onto a staining assay, for example an immunohistochemical (IHC) assay that is commonly registered with the anatomical assay, to locate or determine features appropriate for analysis. The anatomical information may be used to generate a mask that is projected on one or more commonly registered staining assays. A location of the feature of interest in the staining assay may be correlated with the anatomical context provided by the mask, with any features of interest that match the anatomical mask being selected or indicated as appropriate for analysis.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: May 12, 2020
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Srinivas Chukka, Anindya Sarkar, Joerg Bredno
  • Patent number: 10648936
    Abstract: There is provided a blood condition analyzing device including an erythrocyte quantitative evaluation unit configured to evaluate a hematocrit value and/or a hemoglobin amount on the basis of an electrical characteristic of a blood sample at a frequency of 2 to 25 MHz.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: May 12, 2020
    Assignee: Sony Corporation
    Inventors: Yoshihito Hayashi, Marcaurele Brun, Yoichi Katsumoto
  • Patent number: 10624543
    Abstract: A photo-acoustic sensing apparatus (100) for non-invasive measurement of blood parameters of a subject (102) comprises a photo-acoustic sensor (104) for sensing photo-acoustic signals (106) induced when a region of the subject is illuminated by a light source (108). A first sensor processing module (112) may derive blood oxygen saturation using sensed photo-acoustic signals (114). A second sensor processing module (116) may derive blood core temperature using sensed photo-acoustic signals. A third sensor processing module (118) may derive blood glucose using sensed photo-acoustic signals. The sensing apparatus is configured to derive at least one of: a de-correlated value (120) of blood oxygen saturation of the subject; a de-correlated value (122) of blood core temperature of the subject; and a de-correlated value (124) of blood glucose of the subject.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: April 21, 2020
    Assignee: Nanyang Technological University
    Inventors: Yuanjin Zheng, Xiaohua Feng, Fei Gao
  • Patent number: 10623627
    Abstract: The present invention relates to a system for generating a synthetic 2D image with an enhanced depth of field of a biological sample. It is described to acquire (110) with a microscope-scanner (20) first image data at a first lateral position of the biological sample and second image data at a second lateral position of the biological sample. The microscope-scanner is used to acquire (120) third image data at the first lateral position and fourth image data at the second lateral position, wherein the third image data is acquired at a depth that is different than that for the first image data and the fourth image data is acquired at a depth that is different than that for the second image data. First working image data is generated (130) for the first lateral position, the generation comprising processing the first image data and the third image data by a focus stacking algorithm.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 14, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jelte Peter Vink, Bas Hulsken, Martijn Wolters, Marinus Bastiaan Van Leeuwen, Stuart Hamish Shand
  • Patent number: 10620111
    Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: April 14, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin
  • Patent number: 10588577
    Abstract: Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, the framework performs affine template matching of a region of interest from patient signal data with a baseline signal portion by performing an affine waveform transformation of the region of interest. One or more affine ratios may be determined based on the matched region of interest and the baseline signal portion for generating a report or diagnosis of a cardiac event.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: March 17, 2020
    Assignee: Siemens Healthcare GmbH
    Inventor: Hongxuan Zhang
  • Patent number: 10575766
    Abstract: [Object] To measure a form of light scattering in a body more simply. [Solution] A measurement device according to the present disclosure includes: a light source configured to emit at least one kind of measurement light belonging to a predetermined wavelength band toward a measurement region formed by at least a part of a living body; a detection unit configured such that a plurality of sensors are arranged regularly in a predetermined disposition and the measurement light emitted from the light source and transmitted through the living body is detected by the plurality of sensors; and an analysis unit configured to analyze at least one of rectilinearity of the measurement light in the living body and an optical distance from the light source using a detection result of the measurement light detected by the detection unit.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: March 3, 2020
    Assignee: Sony Corporation
    Inventor: Hideo Sato
  • Patent number: 10571391
    Abstract: The present application relates to a method for adjusting a measuring device for measuring a measurand of a medium using at least one measuring sensor, including: laboratory calibration of the measuring device in a calibration solution, laboratory calibration of the measuring device in air, determination of a correction factor for correcting the laboratory calibration value of the measuring device in air to the laboratory calibration value of the measuring device in the calibration solution, on-site calibration of the measuring device in air, using the correction factor to correct the on-site calibration value of the measuring device in air, and on-site adjustment of the measuring device using the corrected on-site calibration value.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: February 25, 2020
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Frank Müller, Peter Lindmüller, Daniel Iten
  • Patent number: 10561348
    Abstract: A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: February 18, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Yun S Park, Sang Kon Bae, So Young Lee
  • Patent number: 10555693
    Abstract: Disclosed in an embodiment is an operating method of portable apparatus for noninvasively measuring blood glucose levels. The method includes: (a) measuring a first signal value according to ambient environmental light when an LED for measuring signals which emits light with wavelengths to be absorbed into or scattered by glucose is switched off; (b) measuring a second signal value according to light which is scattered by or transmitted through subject tissue and enters a photodetecting unit when the LED for measuring signals is switched on; (c) calculating a glucose concentration measurement of a subject by using the first signal value and the second signal value; and (d) adjusting the quantity of the light radiated from the LED for measuring signals by feeding the difference between the glucose concentration measurement and a pre-established first reference value back to the driving current for the LED for measuring signals.
    Type: Grant
    Filed: February 12, 2017
    Date of Patent: February 11, 2020
    Inventor: Hoon Kim
  • Patent number: 10548520
    Abstract: Methods and devices for accurate noninvasive measurement of blood analyte concentrations are disclosed. In an example process, optical properties of a blood vessel proximate to the surface of an exposed body part, for example, the sclera or the backside of the eyelid, is measured. Analyte concentrations are determined based on the measured optical properties.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: February 4, 2020
    Assignee: SANTEC CORPORATION
    Inventor: Changho Chong
  • Patent number: 10548519
    Abstract: Pulse oximeter devices include a first light emitting element that emits red light, a second light emitting element that emits green light or IR light; and a sensor element that detects red and green (or IR) light and that outputs signals representing detected red and green (or IR) light. The pulse oximeter device further includes a flexible substrate, wherein the first light emitting element, the second light emitting element and the sensor element are formed on the flexible substrate. The sensor element is configured to detect the emitted red and green light transmitted through tissue containing blood, and in certain aspects, the sensor element is configured to detect the emitted red and green (or IR) light reflected by tissue containing blood. A signal processing element (e.g., a processor) receives and processes the signals representing detected red and green (or IR) light output by the sensor element to produce signals representing blood oxygenation content.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: February 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Ana Claudia Arias, Claire Lochner, Adrien Pierre, Yasser Khan
  • Patent number: 10517515
    Abstract: A biosensor for monitoring nitric oxide (NO) of a patient in vivo, includes a PPG circuit configured to obtain a first spectral response for light reflected at a first wavelength from skin tissue of the patient, wherein the first wavelength has a high absorption coefficient for nitric oxide in arterial blood flow and obtain a second spectral response for light reflected at a second wavelength from skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for nitric oxide in arterial blood flow. The biosensor further includes a processing circuit configured to determine an NO measurement value for nitric oxide using the first spectral response and the second spectral response and obtain an adjusted measurement value of nitric oxide by compensating the NO measurement value using a measurement value for at least a first species of hemoglobin.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: December 31, 2019
    Assignee: SANMINA CORPORATION
    Inventor: Robert Steven Newberry
  • Patent number: 10508951
    Abstract: A monolithic spectrometer (10) for spectrally resolving light (L), comprises a body (2) of solid material having optical surfaces (3,4,5,6a-6c,8) configured to guide the light (L) along an optical path (E1,E2,E3,E4) inside the body (2). The optical surfaces of the body (2) comprise a segmented focusing surface (6a,6b) comprising first and second continuously functional optical shapes (Ca,Cb) to focus received parts of respective beams (La,Lb) onto respective focal position (fa,fb) in an imaging plane (P) outside the body (2). The second continuously functional optical shape (Cb) is separated from the first continuously functional optical shape (Ca) by an optical discontinuity (Dab) there between.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: December 17, 2019
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventors: Borgert Kruizinga, Hedser van Brug, Frerik van Beijnum
  • Patent number: 10505394
    Abstract: An augmented reality system including a necklace and a contact lens display can be used to project information from the contact lens display onto the retina of the wearer's eye. In one example, the necklace generates a time-varying magnetic field (TVMF) that provides energy and information to the contact lens display via inductive coupling. The necklace can be configured to minimize the amount of energy absorbed by the body of the wearer while maintaining power transfer to the contact lens display. In one example, the necklace includes multiple conductive coils generating constructively interfering TVMs to effectively transmit energy while reducing the amount of energy absorbed by the human body. In another example, the necklace includes a parasitic coil generating a destructively interfering TVMF and a magnetic shield to effectively transmit energy while reducing the amount of energy absorbed by the human body.
    Type: Grant
    Filed: April 21, 2018
    Date of Patent: December 10, 2019
    Assignee: Tectus Corporation
    Inventors: Gregory David Miller, Brian Elliot Lemoff, Hawk Yin Pang, Michael West Wiemer
  • Patent number: 10492732
    Abstract: Provided is a living-body information measurement device including a first light emitting element and a second light emitting element each that emits different light in wavelength, a light receiving element that receives the light emitted from the first light emitting element and the second light emitting element, a control unit that controls a continuous light-emission period of each of the first light emitting element and the second light emitting element so that the continuous light-emission period of the second light emitting element is shorter than the continuous light-emission period of the first light emitting element, and a measuring unit that measures plural living-body information based on the light received in the light receiving element.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: December 3, 2019
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Hideyuki Umekawa, Kazuhiro Sakai, Manabu Akamatsu, Tomoaki Kojima
  • Patent number: 10488320
    Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: November 26, 2019
    Assignee: ABS GLOBAL, INC.
    Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
  • Patent number: 10481138
    Abstract: Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impur
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: November 19, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Kenichi Mishima, Etsuho Kamata, Hiroshi Miura, Yasuhiro Mito, Toshinobu Yanagisawa
  • Patent number: 10481082
    Abstract: A measuring device includes: an irradiator that irradiates electromagnetic waves to an inspection object; a light collector having a reflecting surface that guides, to a light-collecting surface, electromagnetic waves whose incident angle with respect to an incident end facing the inspection object is within a predetermined angle, among the electromagnetic waves that have been transmitted through the inspection object; and a detector that detects the electromagnetic waves guided to the light-collecting surface. The measuring device measures a characteristic of the inspection object based on the detected electromagnetic waves.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: November 19, 2019
    Assignee: YOKOGAWA ELECTRIC CORPORATION
    Inventors: Kazuki Setsuda, Naomichi Chida
  • Patent number: 10473519
    Abstract: A filter mask for use in a flow cytometer includes light blocking features and light passing apertures. The flow cytometer operates to evaluate one or more characteristics of a sample by illuminating the sample and a carrier fluid and collecting light rays that are radiated from the sample and the carrier fluid. The light rays are passed through the filter mask. The light blocking features of the filter mask are arranged to selectively block radiated light at certain radiation angles, while permit light rays having other radiation angles to pass therethrough. A sensor analyzer receives the light rays that pass through to evaluate at least one characteristic of the sample. The light rays can also be separated into two beams, which can be independently filtered using different filter masks. The results can then be compared to provide even more information regarding characteristics of the sample.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: November 12, 2019
    Assignee: Beckman Coulter, Inc.
    Inventors: Michael M. Morrell, Timothy Reed
  • Patent number: 10453551
    Abstract: The behavior and/or internal activities of a microorganism can be simulated using a model of the microorganism. Such simulations can be used to determine the efficacy of treatments, disinfectants, antibiotics, chemotherapies, or other methods of interacting with the microorganism, or to provide some other information about the microorganism. Systems and methods are provided herein for fitting, refining, or otherwise improving such models in an automated fashion. Such systems and methods include performing whole-cell experiments to determine a correspondence between the predictions of such models and the actual behavior of samples of the microorganism. Such systems and methods also include, based on such determined correspondences, directly assessing determined discrete sets of properties of the microorganism and/or of constituents of the microorganism and updating parameters of the model corresponding to the properties of the discrete set such that the overall accuracy of the model is improved.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: October 22, 2019
    Assignee: X Development LLC
    Inventors: Chirath Thouppaurachchi, Ian Peikon, Jason Thompson, Tammo Spalink
  • Patent number: 10430955
    Abstract: Disclosed herein are systems methods for high content screening for microscope imaging. In some embodiments, the system comprises: a microscope; and a processor configured to implement: a slide loader module; a reference imager module; a slide imager module; a region of interest (ROI) finder module; a compare imager module; a calibrator module; and an image stitcher module.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: October 1, 2019
    Assignee: The Regents of the University of California
    Inventors: Erwin Frise, Benjamin Booth, Charles McParland, Keith Beattie, Bill Fisher, Ann S. Hammonds, Susan E. Celniker
  • Patent number: 10416079
    Abstract: A device for optical detection of analytes in a sample includes at least two optoelectronic components. The optoelectronic components include at least one optical detector configured to receive a photon and at least one optical emitter configured to emit a photon. The at least one optical emitter includes at least three optical emitters disposed in a flat, non-linear arrangement, and the at least one optical detector includes at least three optical detectors disposed in a flat, non-linear arrangement. The at least three optical emitters and the at least three optical detectors include at least three different wavelength characteristics.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 17, 2019
    Assignee: Opsolution GMBH
    Inventors: Bjoern Magnussen, Claudius Stern, Wolfgang Koecher
  • Patent number: 10405808
    Abstract: Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘IR’) light; receiving, by an IR camera through a polarizing filter, IR light reflected by the patient; capturing at a time based on a heartrate of the patient, a first IR image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second IR image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second IR image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 10, 2019
    Assignee: International Business Machines Corporation
    Inventors: David R. Draeger, Eric H. Jenney, John D. Vasquez
  • Patent number: 10405807
    Abstract: Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘IR’) light; receiving, by an IR camera through a polarizing filter, IR light reflected by the patient; capturing at a time based on a heartrate of the patient, a first IR image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second IR image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second IR image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: September 10, 2019
    Assignee: International Business Machines Corporation
    Inventors: David R. Draeger, Eric H. Jenney, John D. Vasquez
  • Patent number: 10401346
    Abstract: Implementing a mobile device configured to detect sickle cell traits in a blood sample. The device comprises a mobile device with a camera operatively coupled to a microscope lens. An image converter configured to receive an image form the camera and to perform a noise reduction procedure. The noise reduction procedure manipulates the image to a monochrome image and applies a Gaussian filter. A contour detector detects the contours of the image. An image analysis tool is configured to analyze the contours to identify discrete blood cells and clustered blood cells. The user is then notified if sickle cell traits are present based at least on the shape of the discrete blood cells.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: September 3, 2019
    Inventors: Rachel Olema Aitaru, Bonita Beatrice Nanziri
  • Patent number: 10395368
    Abstract: The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: August 27, 2019
    Assignee: Abbott Laboratories
    Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Marilou L. Coleman, Walter G. Stonas, Willie J. Cowart, Wenjing Li, Ema C. Olah
  • Patent number: 10362996
    Abstract: Provided are light absorption spectrum correction devices, methods of manufacturing the light absorption spectrum correction devices, and methods of correcting a light absorption spectrum. The light absorption spectrum correction device includes: a light source configured to emit light; an attenuated total reflectance (ATR) crystal layer configured to contact a subject and provide an optical passage along which the light emitted from the light source travels to the subject; a pressure sensor configured to detect a contact pressure applied to the ATR crystal layer by the subject; a spectrum detector and analyzer configured to detect light emitted from the ATR crystal layer, form a light absorption spectrum based on the detected light, and determine an intensity of the light emitted from the ATR crystal layer; and a spectrum correction device configured to correct the light absorption spectrum based on the contact pressure.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: July 30, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sangkyu Kim, Joonhyung Lee, Seongho Cho
  • Patent number: 10357189
    Abstract: A biological information acquisition device includes: a light emitting unit which casts light on a living body; a plurality of light receiving units which receives the light transmitted through the living body; and a control unit which controls the light emitting unit and the light receiving units. The control unit causes the light emitting unit to emit light as a measurement light emitting unit, causes a plurality of measurement light receiving units spaced apart from the measurement light emitting unit by a first distance, of the plurality of light receiving units, to receive the light cast from measurement light emitting unit and thus acquires a plurality of light receiving results, and acquires biological information using a first light receiving result with a highest light reception intensity and a second light receiving result with a lowest light reception intensity, of the plurality of light receiving results.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: July 23, 2019
    Assignee: Seiko Epson Corporation
    Inventors: Yasunori Koide, Tetsuji Fujita, Takashi Toya
  • Patent number: 10337975
    Abstract: The invention relates to a method and system for characterizing particles using a flow cytometer comprising generating a waveform, as a digital representation of detected radiated light, and transforming said waveform using one or more basis functions and obtaining one or more coefficients characterizing the waveform. The one or more coefficients characterizing the waveform preferably correspond to particular properties of the particle(s), thereby enabling analysis of physical properties of the particles (such as size or shape) or biological properties of the particles, such as cell type, localization and/or distribution of molecules within the cell and/or on the cell surface, structural elements of the cell such as the nucleus or the cytoskeleton, antibody or antibody-fragment binding to the cell or cell morphology. Preferred embodiments of the invention relate to methods and systems in which the waveform is transformed by a wavelet transformation or Fourier transformation.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: July 2, 2019
    Assignees: Deutsches Rheuma-Forschungszentrum Berlin, A⋅P⋅E Angewandte Physik & Elektronik GmbH
    Inventors: Kristen Feher, Toralf Kaiser, Konrad von Volkmann, Sebastian Wolf
  • Patent number: 10324029
    Abstract: A concentration measurement device including at least one light source; a measurement cell for containing a fluid to be measured; a splitter for dividing light from the light source into incident light being incident into the measurement cell and non-incident light not being incident into the measurement cell; a transmitted-light detector for detecting transmitted light that is the incident light having passed through the measurement cell; a non-incident light detector for detecting the non-incident light; and an arithmetic part for correcting a detection signal of the transmitted-light detector using a detection signal of the non-incident light detector.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: June 18, 2019
    Assignees: TOKUSHIMA UNIVERSITY, FUJIKIN INCORPORATED
    Inventors: Yoshihiro Deguchi, Masaaki Nagase, Michio Yamaji, Nobukazu Ikeda, Kouji Nishino, Masayoshi Kawashima, Kazuteru Tanaka
  • Patent number: 10324019
    Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: June 18, 2019
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin
  • Patent number: 10299708
    Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 28, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Jeroen Poeze, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Ferdyan Lesmana, Massi Joe E. Kiani, Greg Olsen
  • Patent number: 10292628
    Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 21, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Jeroen Poeze, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Ferdyan Lesmana, Massi Joe E. Kiani, Greg Olsen
  • Patent number: 10281369
    Abstract: Disclosed are methods, systems, and devices for detecting biological analytes in a sample. The disclosed technology can be used to obtain readings of analyte concentration in a sample by imaging scattered light from an angled narrow beam illuminator. A fluid sample containing one or more biological, organic, and inorganic analytes including proteins, viruses, bacteria, phages, toxins, peptides, DNA, RNA, hormones, chemicals, drugs, and isotopes can be transferred to a microfluidic device having one or more channels with dimensions to generate capillary action for sample transport. The geometry of the microfluidic device may include a reservoir and sensing area, wherein an immunometric reaction can take place for the narrow beam scanning. The test particle may be coated with a specific binding member that is used to bind the binding pair member on an analyte in a sample. Test particles form the binding and the particle/analyte conjugate may be scanned.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: May 7, 2019
    Assignee: Vor, Inc.
    Inventors: TsungFeng Wu, Yu-Chen Chen
  • Patent number: 10275880
    Abstract: Systems and methods for automatic FOV selection in immunoscore computation that involve reading images for individual markers from an unmixed multiplex slide or single stain slides, and computing the tissue region mask from the individual marker image. The heat map of each marker is determined by applying the low pass filter on the individual marker image channel and selecting the top K highest intensity regions from the heat map as the candidate FOVs for each marker. The candidate FOVs from the individual marker images are merged together in the same coordinate system by either adding all of the FOVs together or by only adding the FOVs from the selected marker images depending on the user's choice, and registering all the individual marker images to a common coordinate system and transferring the FOVs back to the original images.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: April 30, 2019
    Assignees: Ventana Medical Systems, Inc., Providence Health & Services—Oregon
    Inventors: Michael Barnes, Carlo Bifulco, Ting Chen, Alisa Tubbs
  • Patent number: 10251587
    Abstract: The present invention relates to a chemo-optical sensor unit for transcutaneous measurement of a concentration of a gas, comprising: at least one sensing layer adapted to be irradiated with a predetermined radiation; and at least one gas-permeable layer adjacent to one side of the at least one sensing layer, adapted to pass gas whose concentration is to be measured through the gas-permeable layer towards the sensing layer; wherein said chemo-optical sensor unit is adapted to operate with a contact medium between the gas-permeable layer and the skin, wherein said contact medium comprises a first compound other than water; wherein said chemo-optical sensor unit is characterized in that said at least one gas-permeable layer and said at least one sensing layer are permeable to said first compound; and wherein the chemo-optical sensor unit is adapted to measure an optical response of the at least one sensing layer, whose optical response depends on the concentration of the gas.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: April 9, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Hans Willem Van Kesteren, Nicolaas Lambert
  • Patent number: 10254208
    Abstract: A method for analyzing blood samples, including the steps of: preparing a blood sample (1) within a respective container (2) provided with an anticoagulant substance; measuring the rate (V) at which the corpuscular components (1a) contained in the blood sample (1) sediment on the bottom of the container (2), the rate (V) being measured over a predetermined time period (T); detecting, within the time period (T), at least one sedimentation trend (A1, A2, A3) representative of steps of aggregation of the corpuscular components (1a); and comparing the detected sedimentation trend (A1, A2, A3) with at least one reference parameter (P1, P2, P3) representative of at least one given pathology.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: April 9, 2019
    Assignee: GRADEMI BIOTECH S.R.L.
    Inventor: Adelio Missaglia
  • Patent number: 10247721
    Abstract: The present invention relates to a method of diagnosis which identifies one or more individual cells and comprises determining at least one of a cell dimension and a cell area, and determining at least one of dark/light cell contrast characteristics, cell area characteristics, cell color characteristics, cell roughness characteristics, distances between cell nuclei and cell convexity. A computer readable medium, a computer apparatus and a diagnostic system is also provided.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: April 2, 2019
    Inventors: David Galloway, Daniel Mark Maynard
  • Patent number: 10231656
    Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: March 19, 2019
    Assignees: Noninvasix, Inc., The Board of Regents of The University of Texas
    Inventors: Rinat Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Petrov, George Saade, Gayle L. Olson, Tommy G. Cooper
  • Patent number: 10232066
    Abstract: Indicator systems and methods associated with high intensity narrow spectrum light are provided. In one example embodiment, a lighting system can include one or more high intensity narrow spectrum (HINS) light sources configured to emit HINS light. The system can further include an indicator circuit configured to provide at least one indicator associated with one or more parameters of the HINS light and/or operational performance of the HINS light sources.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: March 19, 2019
    Assignee: HUBBELL INCORPORATED
    Inventor: Christopher Lane Bailey
  • Patent number: 10231626
    Abstract: Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection unit for detecting reflectance and fluorescence from the target, an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit, and a control unit for controlling the light source unit and the detection unit. Imaging methods for fluorescence guided surgery are also provided.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 19, 2019
    Assignee: The Regents of the University of California
    Inventors: Paul Steinbach, Quyen T. Nguyen, Roger Y. Tsien
  • Patent number: 10219729
    Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: March 5, 2019
    Assignee: Profusa, Inc.
    Inventors: Gregory J. Kintz, William A. McMillan, Natalie A. Wisniewski
  • Patent number: 10190961
    Abstract: A sample analyzer with an optical detection device and a sample analysis method of the sample analyzer are disclosed. The optical detection device includes a fluid chamber, a light source and a light detector. The fluid chamber includes an illumination zone. An analyte flows through the illumination zone so as to form a sample stream. The light source illuminates the illumination zone to excite cell articles, reacted with a reagent, of the sample stream to emit a light signal. The light detector detects the fluorescent lights and transforms it into an electric signal. The light detector can include a silicon photomultiplier.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: January 29, 2019
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Xiansuan Du, Yong Dai
  • Patent number: 10191267
    Abstract: A microscope system includes: a stage on which a specimen is placed; a light emitting LED configured to emit illumination light for illuminating the specimen; an optical system configured to condense the illumination light emitted by the light emitting LED and irradiate the specimen with the illumination light; an input unit configured to receive an input of a light control signal that adjusts a light amount of the light emitting LED; and a control unit configured to control, when the light control signal is input from the input unit, the light amount of the light emitting LED to become a light amount according to the light control signal by delaying the light control signal by a predetermined time from timing when the light control signal is input.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 29, 2019
    Assignee: OLYMPUS CORPORATION
    Inventors: Hideaki Endo, Hiroshi Watanabe
  • Patent number: 10182749
    Abstract: A health care apparatus and an operating method thereof are provided. The method includes generating a first blood glucose pattern of an examinee that indicates a blood glucose level of the examinee over a first period of time, generating a second blood glucose pattern of the examinee that indicates the blood glucose level of the examinee over a second period of time, generating a third blood glucose pattern of the examinee that indicates the blood glucose level of the examinee over a third period of time, and calculating a glycemic index of the examinee based on the first blood glucose pattern, the second blood glucose pattern, and the third blood glucose pattern.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: January 22, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jinyoung Park, Eunsung Park, Seongho Cho
  • Patent number: 10184880
    Abstract: An airborne particle-measuring device quantifies and qualifies contaminants of an air environment in clean-rooms, open spaces, and enclosed spaces such as homes, offices, industrial environments, airplanes in flight, cars and others. The device may include a sensor system, an electronics system, communications and information storage. The sensor system may include a high-power low-wavelength single-frequency continuous laser, an open-cavity high-efficiency mirror having an optical surface tuned to the laser frequency and a flow system that includes a vacuum pump to sample the air. The electronics system may be mounted on a single multilayer PC board with a microprocessor, firmware, electronics and a touch-screen LCD display. Innovations in light source, flow control, analog and digital signal processing, components integration and software allow provision of equipment in a wide range of high-complexity settings that require precise particle measurements.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: January 22, 2019
    Inventors: Pedro Godoy, Juan Bardina
  • Patent number: 10178971
    Abstract: The invention provides a system (100) for acquiring cervical images which comprises an image acquisition subsystem (120) for acquiring cervical images (122) of a cervical region of a patient during a colposcopy procedure, and a display subsystem (160) for displaying the cervical images on a display (060) by providing image data (162) of the cervical images to the display. According to the invention, the image acquisition subsystem (120) is arranged for, when operating in an interval mode, acquiring the cervical images (122) at predetermined time intervals to obtain a time-series of cervical images showing changes in the cervical region over time, and reporting a progress of said acquiring to the display subsystem. Moreover, the display subsystem (160) is arranged for establishing a progress indicator (400-416) on the display by generating indicator data (164) and providing the indicator data to the display (060), the progress indicator providing visual feedback on the progress of said acquiring to a user.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: January 15, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Lu Wang, Subhendu Seth, Pallavi Vajinepalli, Vipin Gupta, Payal Keswarpu, Sarif Kumar Naik
  • Patent number: 10161852
    Abstract: A system for emitting and detecting electromagnetic radiation of multiple wavelengths to observe the motion of particles in a polydisperse solution in order to size the particles is provided. The system includes a first and second light sources constructed to emit a first and second beams of electromagnetic radiation at substantially a first and second wavelength, respectively. The beams are directed to a specimen chamber such that a portion of the beams scatter when illuminating the particles, and wherein the scattered portion of the beams are directed to a sensor. The first and second wavelengths are different from each other and a recorder is connected to the sensor. At processor controls the light sources in a time-division fashion, and from the resulting images the size of particles can be determined by tracking the motion of the particles.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: December 25, 2018
    Assignee: MANTA INSTRUMENTS, INC.
    Inventors: Jan J. Tatarkiewicz, Rick Cooper