Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.

Abstract: A measuring device includes: an irradiator that irradiates electromagnetic waves to an inspection object; a light collector having a reflecting surface that guides, to a light-collecting surface, electromagnetic waves whose incident angle with respect to an incident end facing the inspection object is within a predetermined angle, among the electromagnetic waves that have been transmitted through the inspection object; and a detector that detects the electromagnetic waves guided to the light-collecting surface. The measuring device measures a characteristic of the inspection object based on the detected electromagnetic waves.

Abstract: Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impur

Abstract: A filter mask for use in a flow cytometer includes light blocking features and light passing apertures. The flow cytometer operates to evaluate one or more characteristics of a sample by illuminating the sample and a carrier fluid and collecting light rays that are radiated from the sample and the carrier fluid. The light rays are passed through the filter mask. The light blocking features of the filter mask are arranged to selectively block radiated light at certain radiation angles, while permit light rays having other radiation angles to pass therethrough. A sensor analyzer receives the light rays that pass through to evaluate at least one characteristic of the sample. The light rays can also be separated into two beams, which can be independently filtered using different filter masks. The results can then be compared to provide even more information regarding characteristics of the sample.

Abstract: The behavior and/or internal activities of a microorganism can be simulated using a model of the microorganism. Such simulations can be used to determine the efficacy of treatments, disinfectants, antibiotics, chemotherapies, or other methods of interacting with the microorganism, or to provide some other information about the microorganism. Systems and methods are provided herein for fitting, refining, or otherwise improving such models in an automated fashion. Such systems and methods include performing whole-cell experiments to determine a correspondence between the predictions of such models and the actual behavior of samples of the microorganism. Such systems and methods also include, based on such determined correspondences, directly assessing determined discrete sets of properties of the microorganism and/or of constituents of the microorganism and updating parameters of the model corresponding to the properties of the discrete set such that the overall accuracy of the model is improved.

Abstract: Disclosed herein are systems methods for high content screening for microscope imaging. In some embodiments, the system comprises: a microscope; and a processor configured to implement: a slide loader module; a reference imager module; a slide imager module; a region of interest (ROI) finder module; a compare imager module; a calibrator module; and an image stitcher module.

Abstract: A device for optical detection of analytes in a sample includes at least two optoelectronic components. The optoelectronic components include at least one optical detector configured to receive a photon and at least one optical emitter configured to emit a photon. The at least one optical emitter includes at least three optical emitters disposed in a flat, non-linear arrangement, and the at least one optical detector includes at least three optical detectors disposed in a flat, non-linear arrangement. The at least three optical emitters and the at least three optical detectors include at least three different wavelength characteristics.

Abstract: Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘IR’) light; receiving, by an IR camera through a polarizing filter, IR light reflected by the patient; capturing at a time based on a heartrate of the patient, a first IR image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second IR image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second IR image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.

Abstract: Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘IR’) light; receiving, by an IR camera through a polarizing filter, IR light reflected by the patient; capturing at a time based on a heartrate of the patient, a first IR image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second IR image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second IR image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.

Abstract: Implementing a mobile device configured to detect sickle cell traits in a blood sample. The device comprises a mobile device with a camera operatively coupled to a microscope lens. An image converter configured to receive an image form the camera and to perform a noise reduction procedure. The noise reduction procedure manipulates the image to a monochrome image and applies a Gaussian filter. A contour detector detects the contours of the image. An image analysis tool is configured to analyze the contours to identify discrete blood cells and clustered blood cells. The user is then notified if sickle cell traits are present based at least on the shape of the discrete blood cells.

Abstract: The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.

Abstract: Provided are light absorption spectrum correction devices, methods of manufacturing the light absorption spectrum correction devices, and methods of correcting a light absorption spectrum. The light absorption spectrum correction device includes: a light source configured to emit light; an attenuated total reflectance (ATR) crystal layer configured to contact a subject and provide an optical passage along which the light emitted from the light source travels to the subject; a pressure sensor configured to detect a contact pressure applied to the ATR crystal layer by the subject; a spectrum detector and analyzer configured to detect light emitted from the ATR crystal layer, form a light absorption spectrum based on the detected light, and determine an intensity of the light emitted from the ATR crystal layer; and a spectrum correction device configured to correct the light absorption spectrum based on the contact pressure.

Abstract: A biological information acquisition device includes: a light emitting unit which casts light on a living body; a plurality of light receiving units which receives the light transmitted through the living body; and a control unit which controls the light emitting unit and the light receiving units. The control unit causes the light emitting unit to emit light as a measurement light emitting unit, causes a plurality of measurement light receiving units spaced apart from the measurement light emitting unit by a first distance, of the plurality of light receiving units, to receive the light cast from measurement light emitting unit and thus acquires a plurality of light receiving results, and acquires biological information using a first light receiving result with a highest light reception intensity and a second light receiving result with a lowest light reception intensity, of the plurality of light receiving results.

Abstract: The invention relates to a method and system for characterizing particles using a flow cytometer comprising generating a waveform, as a digital representation of detected radiated light, and transforming said waveform using one or more basis functions and obtaining one or more coefficients characterizing the waveform. The one or more coefficients characterizing the waveform preferably correspond to particular properties of the particle(s), thereby enabling analysis of physical properties of the particles (such as size or shape) or biological properties of the particles, such as cell type, localization and/or distribution of molecules within the cell and/or on the cell surface, structural elements of the cell such as the nucleus or the cytoskeleton, antibody or antibody-fragment binding to the cell or cell morphology. Preferred embodiments of the invention relate to methods and systems in which the waveform is transformed by a wavelet transformation or Fourier transformation.

Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.

Abstract: A concentration measurement device including at least one light source; a measurement cell for containing a fluid to be measured; a splitter for dividing light from the light source into incident light being incident into the measurement cell and non-incident light not being incident into the measurement cell; a transmitted-light detector for detecting transmitted light that is the incident light having passed through the measurement cell; a non-incident light detector for detecting the non-incident light; and an arithmetic part for correcting a detection signal of the transmitted-light detector using a detection signal of the non-incident light detector.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: Disclosed are methods, systems, and devices for detecting biological analytes in a sample. The disclosed technology can be used to obtain readings of analyte concentration in a sample by imaging scattered light from an angled narrow beam illuminator. A fluid sample containing one or more biological, organic, and inorganic analytes including proteins, viruses, bacteria, phages, toxins, peptides, DNA, RNA, hormones, chemicals, drugs, and isotopes can be transferred to a microfluidic device having one or more channels with dimensions to generate capillary action for sample transport. The geometry of the microfluidic device may include a reservoir and sensing area, wherein an immunometric reaction can take place for the narrow beam scanning. The test particle may be coated with a specific binding member that is used to bind the binding pair member on an analyte in a sample. Test particles form the binding and the particle/analyte conjugate may be scanned.

Abstract: Systems and methods for automatic FOV selection in immunoscore computation that involve reading images for individual markers from an unmixed multiplex slide or single stain slides, and computing the tissue region mask from the individual marker image. The heat map of each marker is determined by applying the low pass filter on the individual marker image channel and selecting the top K highest intensity regions from the heat map as the candidate FOVs for each marker. The candidate FOVs from the individual marker images are merged together in the same coordinate system by either adding all of the FOVs together or by only adding the FOVs from the selected marker images depending on the user's choice, and registering all the individual marker images to a common coordinate system and transferring the FOVs back to the original images.

Abstract: A method for analyzing blood samples, including the steps of: preparing a blood sample (1) within a respective container (2) provided with an anticoagulant substance; measuring the rate (V) at which the corpuscular components (1a) contained in the blood sample (1) sediment on the bottom of the container (2), the rate (V) being measured over a predetermined time period (T); detecting, within the time period (T), at least one sedimentation trend (A1, A2, A3) representative of steps of aggregation of the corpuscular components (1a); and comparing the detected sedimentation trend (A1, A2, A3) with at least one reference parameter (P1, P2, P3) representative of at least one given pathology.

Abstract: The present invention relates to a chemo-optical sensor unit for transcutaneous measurement of a concentration of a gas, comprising: at least one sensing layer adapted to be irradiated with a predetermined radiation; and at least one gas-permeable layer adjacent to one side of the at least one sensing layer, adapted to pass gas whose concentration is to be measured through the gas-permeable layer towards the sensing layer; wherein said chemo-optical sensor unit is adapted to operate with a contact medium between the gas-permeable layer and the skin, wherein said contact medium comprises a first compound other than water; wherein said chemo-optical sensor unit is characterized in that said at least one gas-permeable layer and said at least one sensing layer are permeable to said first compound; and wherein the chemo-optical sensor unit is adapted to measure an optical response of the at least one sensing layer, whose optical response depends on the concentration of the gas.

Abstract: The present invention relates to a method of diagnosis which identifies one or more individual cells and comprises determining at least one of a cell dimension and a cell area, and determining at least one of dark/light cell contrast characteristics, cell area characteristics, cell color characteristics, cell roughness characteristics, distances between cell nuclei and cell convexity. A computer readable medium, a computer apparatus and a diagnostic system is also provided.

Abstract: Indicator systems and methods associated with high intensity narrow spectrum light are provided. In one example embodiment, a lighting system can include one or more high intensity narrow spectrum (HINS) light sources configured to emit HINS light. The system can further include an indicator circuit configured to provide at least one indicator associated with one or more parameters of the HINS light and/or operational performance of the HINS light sources.

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Abstract: Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection unit for detecting reflectance and fluorescence from the target, an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit, and a control unit for controlling the light source unit and the detection unit. Imaging methods for fluorescence guided surgery are also provided.

Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.

Abstract: A sample analyzer with an optical detection device and a sample analysis method of the sample analyzer are disclosed. The optical detection device includes a fluid chamber, a light source and a light detector. The fluid chamber includes an illumination zone. An analyte flows through the illumination zone so as to form a sample stream. The light source illuminates the illumination zone to excite cell articles, reacted with a reagent, of the sample stream to emit a light signal. The light detector detects the fluorescent lights and transforms it into an electric signal. The light detector can include a silicon photomultiplier.

Abstract: A microscope system includes: a stage on which a specimen is placed; a light emitting LED configured to emit illumination light for illuminating the specimen; an optical system configured to condense the illumination light emitted by the light emitting LED and irradiate the specimen with the illumination light; an input unit configured to receive an input of a light control signal that adjusts a light amount of the light emitting LED; and a control unit configured to control, when the light control signal is input from the input unit, the light amount of the light emitting LED to become a light amount according to the light control signal by delaying the light control signal by a predetermined time from timing when the light control signal is input.

Abstract: A health care apparatus and an operating method thereof are provided. The method includes generating a first blood glucose pattern of an examinee that indicates a blood glucose level of the examinee over a first period of time, generating a second blood glucose pattern of the examinee that indicates the blood glucose level of the examinee over a second period of time, generating a third blood glucose pattern of the examinee that indicates the blood glucose level of the examinee over a third period of time, and calculating a glycemic index of the examinee based on the first blood glucose pattern, the second blood glucose pattern, and the third blood glucose pattern.

Abstract: An airborne particle-measuring device quantifies and qualifies contaminants of an air environment in clean-rooms, open spaces, and enclosed spaces such as homes, offices, industrial environments, airplanes in flight, cars and others. The device may include a sensor system, an electronics system, communications and information storage. The sensor system may include a high-power low-wavelength single-frequency continuous laser, an open-cavity high-efficiency mirror having an optical surface tuned to the laser frequency and a flow system that includes a vacuum pump to sample the air. The electronics system may be mounted on a single multilayer PC board with a microprocessor, firmware, electronics and a touch-screen LCD display. Innovations in light source, flow control, analog and digital signal processing, components integration and software allow provision of equipment in a wide range of high-complexity settings that require precise particle measurements.

Abstract: The invention provides a system (100) for acquiring cervical images which comprises an image acquisition subsystem (120) for acquiring cervical images (122) of a cervical region of a patient during a colposcopy procedure, and a display subsystem (160) for displaying the cervical images on a display (060) by providing image data (162) of the cervical images to the display. According to the invention, the image acquisition subsystem (120) is arranged for, when operating in an interval mode, acquiring the cervical images (122) at predetermined time intervals to obtain a time-series of cervical images showing changes in the cervical region over time, and reporting a progress of said acquiring to the display subsystem. Moreover, the display subsystem (160) is arranged for establishing a progress indicator (400-416) on the display by generating indicator data (164) and providing the indicator data to the display (060), the progress indicator providing visual feedback on the progress of said acquiring to a user.

Abstract: A system for emitting and detecting electromagnetic radiation of multiple wavelengths to observe the motion of particles in a polydisperse solution in order to size the particles is provided. The system includes a first and second light sources constructed to emit a first and second beams of electromagnetic radiation at substantially a first and second wavelength, respectively. The beams are directed to a specimen chamber such that a portion of the beams scatter when illuminating the particles, and wherein the scattered portion of the beams are directed to a sensor. The first and second wavelengths are different from each other and a recorder is connected to the sensor. At processor controls the light sources in a time-division fashion, and from the resulting images the size of particles can be determined by tracking the motion of the particles.

Abstract: An observation apparatus according to the present technology includes a microscope optical system, an imaging unit, a spectroscopic unit, and a detection unit. The imaging unit captures an image via the microscope optical system. The spectroscopic unit acquires an absorption spectrum or a Raman spectrum in an ultraviolet, visible, or infrared area via the microscope optical system. The detection unit detect an observation target object in an observed sample by using the absorption spectrum or the Raman spectrum.

Abstract: The invention principally relates to a method of detecting a disease agent in blood, comprising: (i) creating a sample infra-red spectrum representative of the blood, with one or more spectral components, each having a wavenumber and absorbance value; (ii) providing a reference database of spectral models, each model having one or more database spectral components of a wavenumber and an absorbance value, wherein the database spectral components identify disease agents; (iii) determining whether one or more database spectral components corresponds to one or more sample spectral components; and (iv) compiling a list of corresponding database components identified.

Abstract: A biological signal measuring system includes a sensor and a biological signal measuring apparatus configured to calculate a blood refill time of a living tissue of a subject. The sensor includes a pressure applying portion configured to apply pressure on the living tissue, a light emitter configured to emit light toward the living tissue, a light receiver configured to receive reflected light or transmitted light from the living tissue, a first light transmitting member made of a light transmitting material and having one side contacting the light emitter and the other side arranged to contact the subject, a second light transmitting member made of a light transmitting material and having one side contacting the light receiver and the other side arranged to contact the subject, and a light blocking member configured to block light between the light emitter and the light receiver.

Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.

Abstract: Optical film stacks are disclosed. The optical film stacks can include a first reflective polarizer, a second reflective polarizer, and a retardance layer disposed between the first reflective polarizer and the second reflective polarizer.

Abstract: Measuring apparatus (1) for tracking human and/or animal tissues comprising: a working area (2) for receiving a tissue; a detecting unit (5) configured to detect a unique tissue code provided with the tissue placed on the working area (2); a measuring unit (9) configured to automatically measure quantitative properties of the tissue placed on the working area (2); and a processing and storing unit (22) configured to automatically link the quantitative properties with the tissue code and to automatically store the so linked quantitative properties and tissue code such that the quantitative properties can be retrieved based on the tissue code.

Abstract: Disclosed is an operating method of a portable apparatus for noninvasively measuring blood glucose levels, and the method comprising (a) measuring a first signal value according to ambient environmental light and temperature by using at least one light receiving elements when an LED which emits light with wavelengths to be absorbed into or scattered by glucose is switched off; (b) measuring a second signal value according to incident light which is scattered by or transmitted through subject tissue and enters the photodetecting unit when the LED is switched on; (c) calculating a glucose concentration measurement of a subject by using the first signal value and the second signal value; and (d) wherein the quantity of light detected by the photodetecting unit is adjusted by feeding the difference between the glucose concentration measurement and a first reference value back to the photodetecting unit.

Abstract: The invention refers to a method for determining a marker in a small volume of a sample of a bodily fluid, the method comprising the steps of: providing a flow test element having a plurality of functional zones (3, 4, 5, 6, 7), the plurality of functional zones (3, 4, 5, 6, 7) being at least partially fluidly connected and comprising an application zone (3) and a testing zone (5) fluidly connected to the application zone (3) and configured for determination of a marker in a bodily fluid and/or a constituent of the bodily fluid, applying a small volume of a liquid sample to the sample application zone (3) of the flow test element, determining a correct test performance, wherein the step of determining correct test performance comprises the steps of measuring at least one optical parameter for one or more functional zones (3; 4; 5; 6; 7), comparing the at least one optical parameter measured to at least one predefined optical parameter assigned to the one or more functional zones (3; 4; 5; 6; 7), and, if the c

Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.

Abstract: A detecting device for a medium inside a tube portion comprises at least one light source being arranged at a first position relative to the tube portion adapted to be transilluminated with light and being configured to irradiate light onto the tube portion, a detector unit being arranged at a second position relative to the tube portion and being configured to receive light from the at least one light source passed through the tube portion and to analyze a medium inside the tube portion in a spatially resolving manner, and a homogenizing device being arranged at a position between the at least one light source and the tube portion and being configured, for detecting and quantifying differences in brightness due to local differences of the medium inside the tube portion, to create a homogenous and/or isotropic distribution of the light from the at least one light source before the light enters into the tube portion.

Abstract: A side illuminated multi point multi parameter optical fiber sensor that requires no sensitive coating is provided. This sensor comprises an optical fiber having at least one removed cladding section as the sensitive region, at least one probing light source that side illuminates the fiber, a power supply, a detector, a signal processor and a display. The sensitive optical fiber is optically affected by the presence of a measurand medium that can fluoresce, phosphoresce, absorb and/or scatter the probing light. This probing light is guided by the fiber core towards a detector which measures the light intensity and this light intensity is correlated with a measurand.

Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.

Abstract: A microscope-based system and method for simultaneous imaging of several object planes, of a three-dimensional (3D) sample, associated with different depths throughout the sample. The system includes a polyfocal optical portion, adapted to create a plurality of optical channels each of which is associated with an image of a corresponding object plane, and a spectrally-selective portion, adapted to transform the spectral distribution of the image-forming beam of light to a corresponding spatial distribution. The image, registered by a detector, includes an image of an object plane and an image of the spatially-coded spectral distribution. The method effectuates the simultaneous multispectral imaging of the several object planes. The required data-acquisition time is several fold shorter than that taken by a conventional multispectral microscope-based imaging system.

Abstract: A toner amount detection sensor has a substrate, and a case housing. In the substrate, the light emitting element, the first light receiving element, and the second light receiving element are attached with an interval to the same first surface. In the substrate, first and second slits and are provided between a region where the light emitting element is attached and regions where the first light receiving element and the second light receiving element are attached. In the case housing, first and second light shielding walls and are disposed in such a manner as to extend to reach the inside of the first and second slits and when attached to the substrate and first and second light shielding walls and are provided between the light emitting element and the first light receiving element and between the light emitting element and the second light receiving element.

Abstract: The invention relates to a method for quantifying the level of agglutination of particles in a sample, in particular a biological sample, and notably blood. The biological sample is positioned between a light source and a matrix photodetector. The image acquired by the photodetector is representative of the level of agglutination of the particles in the sample. The light source emits a light wave, the spectral band of which extends an optimum 400 and 600 nm, which constitutes an optimum an excessively low absorption and excessively high absorption, given the thickness of the sample.

Abstract: Devices, systems, and methods for measuring the blood loss of a subject during a medical procedure. Blood and other fluids are received within a container, and a blood measurement device determines the hemoglobin concentration of the fluid within the container. The blood measurement device can also calculate the estimated blood loss of the subject based upon the determined hemoglobin concentration and the volume of the fluid within the container and the patient's hemoglobin.

Abstract: Intra-oral imaging apparatus and/or method embodiments can provide digital dental reflectance images used to identify selected areas of interest (AOI) within a dental region of interest (ROI) having selected image characteristics for both hemoglobin's total concentration and oxygenation level. In one embodiment, reflectance images can determine relative total hemoglobin using at least a wavelength band that includes an isobestic wavelength for absorption coefficients of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb).