Abstract: Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.

Abstract: A fundus camera with an OCT measurement module, in which, after the focusing objective, a mirror switches the light to be detected either to the OCT measurement module or an image detector. This design also renders it possible to carry out a method for improved focusing in order to improve the recording quality of the individual modalities. Furthermore, the multimodal measuring instrument distinguishes itself by an operating concept according to the invention. Such combination instruments are advantageous in that, as a result of the reduction from two instruments to one, less space is required than in the case of two separate instruments. Furthermore, reseating of the patient is avoided if recordings or measurements of different modalities should be made for one and the same patient, as a result of which the procedures in the medical practices and clinics can be influenced positively.

Abstract: Stand-off spectrometry systems and methods are described herein. One system includes a laser source configured to emit a single-spectral light, and an optical frequency comb (OFC) coupled to the laser source and configured to generate, using the single-spectral light, a multi-spectral light to determine an absorption spectrum of a substance.

Abstract: Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.

Abstract: A method for measuring characteristics of a sample is provided. The method includes the following steps: obtaining an interference spectrum of the sample; transforming the interference spectrum into a temporal interference signal via a Fourier transform, in which the temporal interference signal includes a plurality of coherence wave packets; separating the wave packets; transforming the wave packets into a plurality of interface interference signals via an inverse Fourier transform; and fitting a plurality of factors of the interface interference signals into a model for obtaining the refractive indexes, the extinction coefficients, and a thickness of the sample.

Abstract: An imager that can provide separated images corresponding to differing depths in a sample is presented. In accordance with some embodiments of the invention, an imager can include a light source; a sample arm that receives light from the light source, directs the light to a sample, and captures light returning from the sample; a modulation source that provides different modulations corresponding to differing imaging depths in the sample; a detector system to receive the captured light from the sample with the different modulations; and a processor that receives signals from the detector system and separates a plurality of images corresponding with the differing image depths in the sample.

Abstract: In part, the invention relates to frequency-domain optical coherence tomography system. The system includes a tunable laser comprising a laser output for transmitting laser light and a laser cavity having a length L, a gain element disposed within the laser cavity; a tunable wavelength selective element disposed within the laser cavity; a reference reflector disposed outside of the laser cavity; an interferometer in optical communication with the laser output and the reference reflector, wherein the interferometer is configured to transmit a portion of the laser light to a sample and combine light scattered from the sample with light scattered from the reference reflector; and a detector in optical communication with the interferometer that receives the combination of light scattered from the sample and the light scattered from the reference reflector and transforms the combination of light into an electronic signal comprising measurement data with respect to the sample.

Abstract: A spectroscopic measurement device includes: a dividing optical system for dividing a measurement beam emitted from each of a plurality of measurement points located within a measurement area of an object to be measured, into a first measurement beam and a second measurement beam; an imaging optical system; an optical path length difference providing means; a detector including a plurality of pixels; a processor for acquiring an interferogram of a measurement point of the object to be measured; a conjugate plane imaging optical system located between the object to be measured and the dividing optical system; and a periodicity providing means located on the conjugate plane.

Abstract: A system and method for sweeping electromagnetic radiation over a first coherence length and a second length over a range of wavelengths to generate an image. Electromagnetic radiation having a first coherence length is generated and swept over a range of wavelengths. Electromagnetic radiation having a second coherence length is generated and swept over a range of wavelengths. The electromagnetic radiation is splitting through a reference path and a sample path; Electromagnetic radiation returned from the reference path and the sample path is detected, wherein the detector generates output signals corresponding to the received electromagnetic radiation. In one embodiment, the output signals are processed to generate an image. The image may be interleaved with data corresponding to the electromagnetic radiation having the first coherence length and the second coherence length.

Abstract: A spectroscopic measurement device includes: a dividing optical system for dividing a measurement beam emitted from each of a plurality of measurement points located within a measurement area of an object to be measured, into a first measurement beam and a second measurement beam; an imaging optical system; an optical path length difference providing means; a detector including a plurality of pixels; a processor for acquiring an interferogram of a measurement point of the object to be measured; a conjugate plane imaging optical system located between the object to be measured and the dividing optical system; and a periodicity providing means located on the conjugate plane.

Abstract: An interferometer apparatus which include two or more coupled fiber optic Michelson interferometers using fiber optic stretches which stretch two or more optical fibers wound around the perimeter of the optical fiber stretchers by the same amount is disclosed. Preferably a pair of reference and sample fiber optic stretches are utilized which run in a push-pull mode of operation. When one of the interferometers is a coherent light interferometer it can be used as a reference distance scale for all of the remaining low coherence light interferometer. A method for measuring a physical property of a device under test is also disclosed using the apparatus of the present invention.

Abstract: Navigational imaging system and method for use in branched luminal structure. Flexible, spatially steerable probe is equipped with forward- and side-imaging mutually complementing means to enable sub-surface imaging, quantitative determination of probe's positioning with respect to anatomical identifiers of structure, forming 3D image of structure in a volume defined by the imaging means, and positioning of probe in registration with a 3D coordinate system that is independent from the structure. Method includes determining anatomical identifiers of luminal structure branches based on 3D and sub-surface images, assigning such identifiers as fiducial points, and correlating the determined identifiers with those obtained from anatomical model to select target branch for further steering the probe.

Abstract: A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the scanned light. The image processing module receives output from the detector and the transducer and generates a photoacoustic microscopy (PAM) image and an optical coherence tomography (OCT) image based on the received output from the detector and the transducer. The PAM and OCT image data may be fused to form a single, OC-PAM image. Additionally, a series of PAM images and OCT images, respectively, may be combined to generate three-dimensional PAM and OCT images, respectively.

Abstract: A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system is operable to produce a laser sheet in a plane intersecting the specimen axis and generally perpendicular thereto. An imaging system is operable to image the area where the laser sheet intersects the specimen axis.

Abstract: An optical coherence tomography (OCT) apparatus includes: a light source; an OCT optical system including: a first light splitter which splits light emitted from the light source into measurement and reference lights, a second light splitter which splits the measurement light into first and second beams, an optical delay path to generate an optical path length difference between the first and second beams, a scan optical system which scans the respective beams on an object to be examined in a transverse direction, a reference optical system, and a detector which receives a spectrum of composite light in which reflected lights of the first and second beams from the object, and the reference light from the reference optical system are combined; and an arithmetic controller which processes an interference signal output from the detector to obtain first and second tomographic images formed respectively by the first and second beams.

Abstract: An optical tomographic imaging apparatus includes a first lens, an optical path branching unit, a second lens and a scanning unit disposed on an optical path of measurement light with which an object to be examined is irradiated. The second lens and the scanning unit are disposed in such a manner that an angle at which the measurement light scanned by the scanning unit is incident on the optical path branching unit satisfies a wavelength separation characteristic of 90% or higher at a wavelength of observation light of the object to be examined in a wavelength band of the measurement light.

Abstract: The present invention relates to an apparatus having a simple configuration capable of correctly detecting malfunction of an OCT apparatus by detecting the states of a light source and a sensor. An image pickup apparatus includes a switching unit that switches between a first mode in which a combined light beam of a return light beam from a specimen and a reference light beam is detectable by a detecting unit and a second mode in which the reference light beam is detectable by the detecting unit. The image pickup apparatus is switchable to the first mode on the basis of an intensity of the reference light beam detected by the detecting unit in the second mode.

Abstract: An optical probe suitable for medical or dental tomography is switchable between a rotating and non-rotating mode to control interference between source signals and data signals. The probe is suitably constructed in an in-line configuration and uses Faraday rotators which rotate polarization in the same direction in a rotating mode and rotate polarization in opposite directions in a non-rotating mode.

Abstract: An ophthalmic laser treatment apparatus includes an irradiation position obtaining unit arranged to obtain analysis result data based on a tomographic image of a patient's eye captured by an optical coherence tomography device before a treatment laser beam is irradiated, and obtain information of an irradiation position of the treatment laser beam with respect to the eye set by use of the obtained analysis result data, and a laser control unit arranged to irradiate the laser beam to the eye based on the irradiation position information obtained by the irradiation position obtaining unit.

Abstract: A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system is operable to produce a laser sheet in a plane intersecting the specimen axis and generally perpendicular thereto. An imaging system is operable to image the area where the laser sheet intersects the specimen axis.

Abstract: Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

Abstract: An apparatus and method are provided. In particular, a radiation can be provided which includes at least one first electro-magnetic radiation directed to a sample and at least one second electro-magnetic radiation directed to a reference, whereas a frequency of the radiation varies over time. An interference between at least one third radiation associated with the first radiation(s) and at least one fourth radiation associated with the second radiation(s) can be detected to generate an electrical first signal. A second signal associated with at least one phase of at least one frequency component of the electrical first signal can be obtained. Further, comparison data can be generated by comparing the second signal to at least one particular information.

Abstract: A system includes a waveguide that guides a beam of radiation, a variable delay unit, and a polarization-dependent modulating unit. The variable delay unit modulates the refractive index in a region, and the waveguide makes a plurality of passes through the region. The polarization-dependent element compensates for birefringence associated with the beam of radiation and includes a polarization splitter and a plurality of modulating elements. The polarization splitter has a first arm and a second arm that each include modulation segments. The beam of radiation is split between the first arm and the second arm and recombined after traversing the modulation segments. The recombination of the beam generates a first polarized beam of radiation and a second polarized beam of radiation. The plurality of modulating elements apply a first and second modulation to the first polarized beam of radiation and the second polarized beam of radiation respectively.

Abstract: A SPM head incorporates a probe and a cantilever on which the probe is mounted. The cantilever has a planar reflecting surface proximate a free end of the cantilever. The cantilever extends from a mechanical mount and a single-mode optical fiber is supported by the mechanical mount to provide a beam axis at an angle away from normal relative to the reflecting surface.

Abstract: Navigational imaging system and method for use in branched luminal structure. Flexible, spatially steerable probe is equipped with forward- and side-imaging mutually complementing means to enable sub-surface imaging, quantitative determination of probe's positioning with respect to anatomical identifiers of structure, forming 3D image of structure in a volume defined by the imaging means, and positioning of probe in registration with a 3D coordinate system that is independent from the structure. Method includes determining anatomical identifiers of luminal structure branches based on 3D and sub-surface images, assigning such identifiers as fiducial points, and correlating the determined identifiers with those obtained from anatomical model to select target branch for further steering the probe.

Abstract: An ophthalmologic image display apparatus for displaying information about an eye includes an input unit configured to input a tomographic image of the eye, an acquisition unit configured to acquire diagnostic supporting information associated with positional information about the tomographic image of the eye, a processing unit configured to perform processing for assigning a voxel value to volume data constituting the tomographic image based on a reflection intensity value indicating the tomographic image and the diagnostic supporting information, and a display control unit configured to cause a display unit to display an image processed by the processing unit.

Abstract: A system for lateral scanning of a sample using optical coherence tomography is presented. The low coherence interferometry system includes a first multiplexing unit and a second multiplexing unit. The first multiplexing unit is configured to receive a first beam of radiation and includes a first plurality of optical delay elements configured to introduce a group delay to the first beam of radiation based on an optical path traversed by the first beam of radiation among a first plurality of optical waveguides. The second multiplexing unit is configured to receive a second beam of radiation. The second multiplexing unit includes a second plurality of optical modulating elements configured to differentiate the second beam of radiation among a second plurality of optical waveguides to produce one or more output radiation beams. The second plurality of optical waveguides is configured to guide the one or more output radiation beams towards a sample.

Abstract: An automatic or semiautomatic method of processing intravascular Optical Coherence Tomography (OCT) images, comprising: pre-processing the primary image by segmenting the guidewire in the lumen to exclude it from the image, determining whether the lumen is open or closed; if the lumen is determined to be closed, performing a first automatic lumen segmentation procedure on the pre-processed image to define a perimeter line of the lumen, corresponding to the inner edge of the vessel wall, and determine a centroid CL of the lumen area; if the lumen is determined not to be closed, sequentially performing an automatic lumen closing procedure on the pre-processed image, and a second automatic lumen segmentation procedure, to define a perimeter line of the lumen, corresponding to the inner edge of the vessel wall, and determine a centroid CL of the lumen area; automatically finding an outer edge of the vessel wall and defining a first region of interest ROI1 between the inner edge and the outer edge of the lumen; au

Abstract: An apparatus for measuring the optical performance characteristics and dimensions of an optical element comprising a low coherence interferometer and a Shack-Hartmann wavefront sensor comprising a light source, a plurality of lenslets, and a sensor array is disclosed. The low coherence interferometer is configured to direct a measurement beam along a central axis of the optical element, and to measure the thickness of the center of the optical element. The light source of the Shack-Hartmann wavefront sensor is configured to emit a waveform directed parallel to and surrounding the measurement beam of the interferometer, through the plurality of lenslets, and to the sensor array. A method for measuring the optical performance characteristics and dimensions of a lens using the apparatus is also disclosed.

Abstract: A calibration jig allowing simple and repeatable calibration of a probe optical tomographic apparatus is disclosed. The jig includes a holding member removably attachable to an attachment section of the apparatus and a reflective surface held by the holding member. The reflective surface reflects measurement light emitted from an emitting section of the attachment section and directs reflected light back to the emitting section. If a probe of the apparatus is covered with a sheath, the jig may include a light transmitting member, which generates the same dispersion as dispersion at the sheath, between the emitting section and the reflective surface. The reflective surface may be a single reflective surface disposed within an area corresponding to twice a coherence length of the laser light with a zero path position of the reflective surface being the center of the area.

Abstract: An OCT measuring mechanism for acquiring the optical coherence tomography information and a surface shape measuring mechanism for acquiring the three-dimensional shape information share a display device, a control device, a light source, a scanning mirror, a light transmission/receiving path and an entering/exiting opening. The scanning mirror, the light transmission/receiving path, the entering/exiting opening are included in a handpiece operable to make a diagnosis on a diagnostic target site.

Abstract: The invention generally relates to methods for calibrating an OCT image by comparing a detected location of a feature within the image to an expected location of the feature, calculating a calibration value, and transforming the location of pixels within the image to provide a calibrated image.

Abstract: An apparatus and method for determining a depth of a region having a high aspect ratio that protrudes into a surface of a semiconductor wafer are provided. The apparatus comprises a multi-wavelength light source, a semiconductor wafer holder for holding a semiconductor wafer, a head for directing the light source onto the semiconductor wafer, a spectrometer for collecting light comprising multiple wavelengths reflected from the semiconductor wafer and analysis means for determining a depth of the region from an interference pattern of light reflected from the semiconductor wafer by performing Fourier domain optical coherence tomography.

Abstract: An optical coherence tomographic apparatus which obtains a tomographic image of an object based on light obtained by combining return light from the object irradiated with measurement light through a first lens and reference light corresponding to the measurement light, the apparatus comprises a scanning unit provided on an optical path of the measurement light and configured to scan the measurement light on the object; a second lens disposed between the scanning unit and the object; an optical path branching unit disposed between the first lens and the second lens and configured to make the optical path of the measurement light branch off to an observation optical path for observation of the object; a dividing unit that splits light emitted from a light source into the measurement light and the reference light; and a focus lens disposed between the dividing and scanning units.

Abstract: A system and method for depth-resolved imaging of a sample are presented. The system for depth-resolved imaging of a sample includes a substrate of substantially flexible material, a plurality of waveguides disposed on the substrate, an optical element disposed at a distal end of the plurality of waveguides, and one or more interferometers. Light is collected from the sample through the optical element and plurality of waveguides on the flexible substrate on its path to the one or more interferometers. The interferometers are configured to combine a reference light with the light received by at least a portion of the plurality of waveguides to resolve contributions from one or more depths of the sample. The system further includes a light guiding element coupled between the plurality of waveguides and the one or more interferometers.

Abstract: Accordingly, exemplary embodiments of an apparatus obtaining information associated with a structure can be provided. For example, with a first arrangement, it is possible to separate at least one first electro-magnetic radiation into a first radiation and a second radiation forwarded to the structure, with the first and second radiations having different path lengths. Using a second arrangement, it is possible to receive third and fourth radiations from the structure associated with the first and second radiations and a fifth radiation received from a reference. Further, with a third arrangement, it is possible to generate data corresponding to an amount of a ranging depth within the structure associated with the second arrangement. For example, a difference between the path lengths of the first and second radiations is equal or greater than the ranging depth.

Abstract: The invention relates to a method and an apparatus for collecting structural data with spectral optical coherence tomography from samples having a point of maximum reflectance. This point of maximum reflectance is used for adjusting the scanned path pattern.

Abstract: An optical tomographic image acquisition apparatus includes a light source unit emitting light; a light dividing device dividing the light from the unit into measurement light and reference light; a projecting device arranged inside a tubular sheath to project the measurement light onto an object; a combining device combining reflected light reflected from the object or the sheath and the reference light; an interference light detecting device detecting interference light between the reflected light and the reference light; an interference signal acquiring device acquiring an interference signal; a tomographic image acquiring device acquiring an optical tomographic image; and a reference position adjustment section detecting a sheath interference signal that is an interference signal of the reflected light reflected from the sheath from the interference signals and adjusts an optical tomographic image reference position as a reference to acquire the optical tomographic image based on the detected sheath inter

Abstract: Angle multiplexed optical coherence tomography systems and methods can be used to evaluate ocular tissue and other anatomical structures or features of a patient.

Abstract: An exemplary device has a stationary portion and a movable portion. The stationary portion has a first corner-cube, an optical system including a beamsplitter, and a light detector. The movable portion comprises a second corner-cube mountable on an object that is displaceable in a principal direction relative to the stationary portion. The beamsplitter splits a beam of collimated broadband light into a reference beam and a measurement beam that are directed by the optical system to make multiple roundtrip passes from the optical system to the respective corner cubes and back. The reference beam and measurement beam interfere with each other to produce a coherence envelope sensed by the detector, wherein a detected displacement of the coherence envelope corresponds to a respective position of the object in the principal direction.

Abstract: An image data set acquired by an optical coherence tomography (OCT) system is corrected for effects due to motion of the sample. A first set of A-scans is acquired within a time short enough to avoid any significant motion of the sample. A second more extensive set of A-scans is acquired over an overlapping region on the sample. Significant sample motion may occur during acquisition of the second set. A-scans from the first set are matched with A-scans from the second set, based on similarity between the longitudinal optical scattering profiles they contain. Such matched pairs of A-scans are likely to correspond to the same region in the sample. Comparison of the OCT scanner coordinates that produced each A-scan in a matching pair, in conjunction with any shift in the longitudinal scattering profiles between the pair of A-scans, reveals the displacement of the sample between acquisition of the first and second A-scans in the pair.

Abstract: In one embodiment, the invention relates to an apparatus for increasing the repetition rate in a light source. The apparatus includes a first optical coupler comprising a first arm, a second arm and a third arm; a first mirror in optical communication with the second arm of the first optical coupler; and a first optical delay line having a first end in optical communication with the third arm of the first optical coupler and a second end in optical communication with a second mirror, wherein light entering the first arm of the first optical coupler leaves the first arm of the first optical coupler either delayed by an amount (?) or substantially undelayed.

Abstract: A short coherence interferometer for measuring several axially spaced-apart regions of a sample, especially of an eye, which has a measuring optical path, through which the measuring radiation falls on the sample, a tunable interferometer for the axial, relative retardation of parts of the radiation, wherein the axial relative retardation is assigned to the axial spacing of the regions and a detector for producing an interference signal from interfering measurement radiation, scattered or reflected back from the sample as sample radiation. The tunable interferometer divides the sample radiation into two parts, which are axially relatively retarded and superimposed so as to interfere. During the superimposition, the tunable interferometer forms individual radiations, which represent quadrature components of the sample radiation, and the detector detects the individual radiations.

Abstract: A microscope device for inspecting structured objects, including: a camera; an optical imager capable of producing, on the camera, an image of the object according to a field of view, and including a distal lens arranged on the side of the object; and a low-coherence infrared interferometer including a measurement beam capable of producing measurements by means of interferences between retroreflections of the measurement beam and at least one separate optical reference. The device also includes coupler for injecting the measurement beam into the optical imaging means in such a way that the beam passes through the distal lens, and the low-coherence infrared interferometer is balanced in such a way that only the measurement beam retroreflections, taking place at optical distances close to the optical distance covered by the beam to the object, produce measurements.

Abstract: An optical coherence tomography apparatus which acquires a tomogram of a target object based on a light intensity detected for each wavelength by combining return light of measurement light from the target object with reference light corresponding to the measurement light, the apparatus comprising: a normalization unit adapted to normalize the light intensity detected for the each wavelength based on a transfer function corresponding to the wavelength resolution; and an image formation unit adapted to form a tomogram of the target object from the light intensities normalized by the normalization unit.

Abstract: An optical tomographic imaging method according to one aspect of the present invention is a method of: splitting light emitted from a wavelength sweep light source into measuring light and reference light; radiating the measuring light onto a measuring subject; combining reflection light from the measuring subject with the reference light; detecting interfered light obtained by combining the reflection light with the reference light as an interference signal; and Fourier-transforming the interference signal to acquire a tomographic image of the measuring subject, and includes steps of: generating tomographic data of the measuring subject based on the interference signal; generating surface data of the measuring subject based on the interference signal; constructing a tomographic image that is based on the generated tomographic data; constructing a surface image that is based on the outputted surface data; and generating a display image from the tomographic image and the surface image.

Abstract: There is disclosed a method for detecting spatially structured sample volumes by means of coherent light and digital holography. There is also disclosed a method for analyzing the depth structure of samples in accordance with optical coherence tomography.

Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes. In one embodiment, a scanning reflector surface is configured to be rotated about two axes in a single operating plane to direct light transmitted along the sample path to a sample to be imaged.

Abstract: An interferometry system for monitoring changes in the position of an object, the system includes a spectrally broadband light source, a sensor module having an interferometer that direct portions of the light received from the source along separate paths. The system includes an intensity monitor having a detector configured to measure the intensity of additional light derived from the source and to produce a monitor output signal. The system includes an electronic processing module to process a sensor output signal based on the monitor output signal to account for intensity fluctuations in light output by the source, and determine information about the changes in the position of the object. The intensity monitor is configured to characterize the intensity fluctuations as a function of wavelength or intensity fluctuations that are spectrally correlated.

Abstract: An imaging apparatus adjusts the polarization directions of irradiation beams (to a diffraction grating) corresponding to first and second beams respectively which have different polarization directions (for example, by adjusting a relative angle formed between light-emitting ends of respective polarization maintaining fibers) so that the spectral characteristics of the irradiation beams at the diffraction grating coincide with each other. Then, the imaging apparatus acquires a tomographic image indicating polarization information for a object based on beams (that come from the diffraction grating for splitting and diffracting a beam from the adjustment unit) corresponding to the first and second beams respectively which have different polarization directions.