Plural Test Patents (Class 356/73)
  • Patent number: 11226546
    Abstract: A detecting device for use in multiple-DOF spherical body, which is applied in a camera and a spherical body, and includes: a fasten plate; at least one rotation mechanism; at least one rolling device; and at least one elevation device; and characterized in: the fasten plate has a bottom plate and plural bottom support rods are disposed between the bottom plate and the fasten plate, the bottom plate has a second rotation mechanism having a second fasten plate and a motor output shaft, the fasten plate has a second elevation device at the bottom and a elevation plate at the top and has a second top rotation disk set and a rotation disk input shat, connection guiding rods are disposed between the elevation plate and the second fasten plate, and the second top rotation disk set has a tray and at least one spherical body holding ring.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: January 18, 2022
    Assignee: TRIDSEARCH CO., LTD.
    Inventors: Hsueh-Lung Lu, Chien-Chih Chang
  • Patent number: 11215511
    Abstract: A wavefront detector (100) and method for determining a signal wavefront (Ws) of a signal beam (Ls). A beam combiner (11) is configured to combine the signal beam (Ls) with a reference beam (Lr). An image detector (12) comprising an array of photosensitive pixels (12p) is configured to receive and measure an interference pattern (Wrs) of the combined signal and reference beams (Lr+Ls). A reference light source (14) is configured to generate the reference beam (Lr). A feedback controller (20) is configured to receive an interference signal (IB) based on measurement of at least part of the combined signal and reference beams (Lr+Ls), and control generation of the reference beam (Lr) by a feedback loop based on the interference signal (IB).
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: January 4, 2022
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventor: Rudolf Saathof
  • Patent number: 11204557
    Abstract: Disclosed is a method of measuring focus performance of a lithographic apparatus. The method comprises using the lithographic apparatus to print at least one focus metrology pattern on a substrate, the printed focus metrology pattern comprising at least a first periodic array of features, and using inspection radiation to measure asymmetry between opposite portions of a diffraction spectrum for the first periodic array in the printed focus metrology pattern. A measurement of focus performance is derived based at least in part on the asymmetry measured. The first periodic array comprises a repeating arrangement of a space region having no features and a pattern region having at least one first feature comprising sub-features projecting from a main body and at least one second feature; and wherein the first feature and second feature are in sufficient proximity to be effectively detected as a single feature during measurement. A patterning device comprising said first periodic array is also disclosed.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: December 21, 2021
    Assignee: ASML Netherlands B.V.
    Inventor: Frank Staals
  • Patent number: 11125549
    Abstract: Methods and apparatus for measuring a thickness of a coating on an moving object are provided. Light is directed toward the object at a predetermined location on the object such that a portion of the light interacts with the object. A 1D and/or 2D maximum intensities for at least one wavelength channel is captured that is produced by the portion of the light interacting with the object. A measured average intensity of the wavelength channel and/or intensities and their arithmetic derivatives of multi wavelength channel geometries is converted into 1D (averaged) and/or 2D thickness values. Based on these values an acceptability of the coating is evaluated and thickness calculated.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: September 21, 2021
    Assignee: Arkema Inc.
    Inventors: Gunter E. Moeller, Roman Y. Korotkov, Ryan C. Smith
  • Patent number: 11112338
    Abstract: Disclosed are methods, systems, and devices for detecting biological analytes in a sample. The disclosed technology can be used to obtain readings of analyte concentration in a sample by imaging scattered light from an angled narrow beam illuminator. A fluid sample containing one or more biological, organic, and inorganic analytes including proteins, viruses, bacteria, phages, toxins, proteins, peptides, DNA, RNA, hormones, chemicals, drugs, and isotopes can be transferred to a microfluidic device having one or more channels with dimensions to generate capillary action for sample transport. The geometry of the microfluidic device may include a reservoir and sensing area, wherein an immunometric reaction can take place for the narrow beam scanning. The test particle may be coated with a specific binding member that is used to bind the binding pair member on an analyte in a sample. Test particles form the binding and the particle/analyte conjugate may be scanned.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: September 7, 2021
    Assignee: SAN HEH PHARMACEUTICAL CORPORATION
    Inventors: TsungFeng Wu, Yu-Chen Chen
  • Patent number: 11099002
    Abstract: A system for inspecting a coating on a substrate, the system including a platform that receives a sample including the substrate having the coating, and a light source that directs a plurality of electromagnetic pulses towards a scanning location on the coating, wherein the light source is oriented to direct the plurality of electromagnetic pulses at an oblique angle relative to a surface of the coating. A light detector receives electromagnetic pulses reflected from the sample, wherein a first portion of each electromagnetic pulse is reflected from the surface of the coating, and a second portion of each electromagnetic pulse is reflected from a surface of the substrate. An actuator is coupled to the platform and/or the light source, wherein the actuator moves the platform and the light source relative to each other such that the plurality of electromagnetic pulses are directable towards the scanning location from different rotational positions.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: August 24, 2021
    Assignee: General Electric Company
    Inventors: Esha Sen Gupta, Shyamsunder Tondanur Mandayam
  • Patent number: 11085825
    Abstract: Aspects of the disclosure relate to a self-referenced spectrometer for providing simultaneous measurement of a background or reference spectral density and a sample or other spectral density. The self-referenced spectrometer includes an interferometer optically coupled to receive an input beam and to direct the input beam along a first optical path to produce a first interfering beam and a second optical path to produce a second interfering beam, where each interfering beam is produced prior to an output of the interferometer. The spectrometer further includes a detector optically coupled to simultaneously detect a first interference signal produced from the first interfering beam and a second interference signal produced from the second interfering beam, and a processor configured to process the first interference signal and the second interference signal and to utilize the second interference signal as a reference signal in processing the first interference signal.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: August 10, 2021
    Assignee: SI-WARE SYSTEMS
    Inventors: Mostafa Medhat, Bassem Mortada, Yasser Sabry, Mohamed Hossam, Momen Anwar, Ahmed Shebl, Hisham Haddara, Bassam A. Saadany
  • Patent number: 11048016
    Abstract: An apparatus includes flow path units 15A to 15K configured to form flow paths 17A to 17K through which a fluid supplied to a target object W is flown; a laser light irradiator 51 configured to irradiate a laser light into the flow path units such that an optical path intersects with a flow direction of the fluid in the flow path units; light receiving elements 45A and 45B provided at the optical path having passed through the flow path units; a detector 6 configured to detect the foreign substance in the fluid based on a signal from the light receiving elements; and a filter unit 57 provided at the optical path between the light receiving elements and the flow path units, and configured to block a Raman scattered light and allow a Rayleigh scattered light to be transmitted to the light receiving elements.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: June 29, 2021
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Masato Hayashi, Kohei Noguchi, Daisuke Kajiwara, Koudai Higashi
  • Patent number: 11029341
    Abstract: A low-noise alternating current sensor enables low-cost, large dynamic range current measurements of low-frequency alternating current flows. The low-noise current sensor offers enhanced dynamic range and fine-grained sensitivity unavailable in existing sensor technology. The sensor's dynamic range and sensitivity to low-frequency AC enable new capabilities in precision current control: a valuable and necessary capability in the control and management of circuit considerations, from applications for the grid to transportation, to the control of remote assets.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: June 8, 2021
    Inventor: James William Masten, Jr.
  • Patent number: 11011436
    Abstract: Whether a film on a peripheral portion of a substrate is appropriately removed is rapidly determined without depending on a kind of the film on the peripheral portion to be removed. An acquisition process S502 of acquiring information upon the kind of the film of the substrate; a selection process S503 of selecting a measurement setting corresponding to the acquired kind of the film from a table for measurement settings previously stored in a storage unit; a control process S504 of controlling an imaging unit 270 to image the peripheral portion of the substrate by using the measurement setting selected in the selection process are provided.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: May 18, 2021
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Yoshifumi Amano, Satoshi Morita, Ryoji Ikebe, Isamu Miyamoto
  • Patent number: 10998974
    Abstract: An optical device is formed on an optical IC chip. The optical device includes: an optical device circuit; a first optical waveguide that is coupled to the a first grating coupler; a second grating coupler; a polarization rotator that is coupled to the first grating coupler; a polarization beam combiner or a polarization beam splitter that is coupled to the polarization rotator and to the second grating coupler; and a second optical waveguide that is coupled to the polarization beam combiner or to the polarization beam splitter. The first optical waveguide and the second optical waveguide respectively extend to an edge of the optical IC chip.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: May 4, 2021
    Assignee: FUJITSU OPTICAL COMPONENTS LIMITED
    Inventor: Masaki Sugiyama
  • Patent number: 10976295
    Abstract: Systems and methods for generating a Methane number for a compressed natural gas fuel by obtaining compositional data from one or more particular analyzers and applying the obtained compositional data to one or more selectable Methane number generation protocols. The systems and methods can include refining of the compressed natural gas fuel to meet a predetermined Methane number.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: April 13, 2021
    Assignee: Mustang Sampling LLC
    Inventor: Richard L. Cline
  • Patent number: 10969299
    Abstract: A lens refractive index detection device is disclosed which has a light source module, a lens center physical thickness detection module and a lens center optical thickness detection module. The light source module includes a first light source component and a second light source component for outputting a collimated light beam, a first light combining component, and a focusing component. The lens center physical thickness detection module includes a first imaging component and a second imaging component. The lens center optical thickness detection module includes a first photodetection component and a second photodetection component, a beam splitting component, a partial reflection mirror, and a movable reflection mirror. The lens refractive index detection device enables simple operation, fast and non-destructive on-line detection, and is also applicable to lenses with irregular surfaces, such as aspherical lenses, cylindrical lenses, and finished lenses.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: April 6, 2021
    Inventors: Yibing Liu, Zhao Sun, Liwei Liu
  • Patent number: 10969598
    Abstract: Polarized pixelated filter sub-array is reconfigured to reduce sensitivity to misalignment. The condition number increases more slowly than the standard polarized pixelated filter sub-array as the misalignment increases. In different embodiments, the filter sub-array is configured such that the condition number has a finite bound at ½ pixel misalignment. The angular values of the polarizer filter array are determined to minimize the sensitivity of the condition number of the data reduction matrix to misalignment. This can be achieved by selecting angular values that minimize the expected value of the condition number E(CN) over the range of misalignment.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: April 6, 2021
    Assignee: Raytheon Company
    Inventors: Eric C. Fest, Jon E. Leigh
  • Patent number: 10949992
    Abstract: The invention relates to a system which includes an observation device (14) including a camera (7) and a cooperative optronic beacon (13) providing all the necessary information to the observation device in order to localize it with a 6D coordinates (position and attitude); thus the invention provides a solution to the problem of a 6D localization of a camera using one single cooperative optronic beacon (13); thanks to the information provided by the cooperative optronic beacon (13), this allows the camera (7) of the observation device (14), by observing this cooperative optronic beacon (13) and by processing the corresponding information, to determine its own 6 localization coordinates in reference to this cooperative optronic beacon (13); so the system according to the invention is suited in particular for the localization of drones, robots, Smartphone, etc. in environments where presence of other localization services (GPS or others) are not available.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: March 16, 2021
    Inventor: Francis Bretaudeau
  • Patent number: 10942125
    Abstract: Disclosed herein is an apparatus, which comprises an optical waveguide, a first and second waveguide couplers. The optical waveguide may be configured to receive light from an end surface of the optical waveguide. The first waveguide coupler may be coupled, at a first coupling strength, to a first portion of the optical waveguide. The second waveguide coupler may be coupled, at a second coupling strength, to a second portion of the optical waveguide. Attenuation of the light at the first portion is smaller than attenuation of the light at the second portion. The first coupling strength is smaller than the second coupling strength. The first waveguide coupler and the second waveguide coupler each comprises a surface comprising sites configured to attach a probe.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: March 9, 2021
    Assignee: Shenzhen Genorivision Technology Co., Ltd.
    Inventors: Peiyan Cao, Rui Ding, Yurun Liu
  • Patent number: 10928296
    Abstract: The disclosure relates to devices and methods for analyzing particles in a sample. In various embodiments, the present disclosure provides devices and methods for cytometry and additional analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing particles in a sample.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: February 23, 2021
    Assignee: CYTOCHIP INC.
    Inventors: Wendian Shi, Yuzhe Ding
  • Patent number: 10914666
    Abstract: A system comprising a parts-per-million (PPM) analyzer configured to analyze a multiphase fluid, the fluid comprising water. The analyzer includes a mesh comprising first adsorbent materials that adsorb specific substances from the multiphase fluid. The system includes a mass meter configured to measure a mass of multiphase fluid passing through the PPM analyzer; a molecular sieve dryer comprising second adsorbent material configured to adsorb the water from the multiphase fluid; and a plurality of valves configured to couple the mass meter and the molecular sieve dryer to the PPM analyzer. During routine operation, the valves direct the multiphase fluid through the PPM analyzer. During a validation operation, the valves divert the multiphase fluid through the molecular sieve dryer prior to entering the PPM analyzer.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: February 9, 2021
    Assignee: Phase Dynamics, Inc.
    Inventor: Bentley N. Scott
  • Patent number: 10905978
    Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: February 2, 2021
    Assignee: POCARED Diagnostics LTD.
    Inventors: Jonathan Gurfinkel, Gal Ingber
  • Patent number: 10900776
    Abstract: A sensing device for measuring an offset along a longitudinal axis comprises a housing including a plurality of slots, two or more arrays of optical sensors aligned along the longitudinal axis, at least one of the arrays being offset along the longitudinal axis with respect to the other arrays and a microcontroller coupled to the two or more arrays of optical sensors and configured to determine a positional offset along the longitudinal axis at which light is detected by at least one of arrays of optical sensors. In some embodiments, each of the optical sensors of the arrays are positioned within the housing underneath one of the plurality of slots to reduce an angle of incidence of radiation received.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: January 26, 2021
    Assignee: Saudi Arabian Oil Company
    Inventors: Brian Parrott, Sahejad Patel, Fadl Abdellatif, Pablo Carrasco Zanini, Ayman Amer, Ali Outa, Abdullah Arab
  • Patent number: 10900834
    Abstract: The Fabry-Perot interference filter includes: a substrate having a first surface, a first laminate having a first mirror portion disposed on the first surface, a second laminate having a second mirror portion facing the first mirror portion with an air gap interposed therebetween, and an intermediate layer defining the air gap between the first and second laminate. The substrate has an outer edge portion positioned outside an outer edge of the intermediate layer when viewed from a direction perpendicular to the first surface. The second laminate further includes a covering portion covering the intermediate layer and a peripheral edge portion positioned on the first surface in the outer edge portion. The second mirror portion, the covering portion, and the peripheral edge portion are integrally formed so as to be continuous with each other. The peripheral edge portion is thinned along an outer edge of the outer edge portion.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: January 26, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Takashi Kasahara, Katsumi Shibayama, Masaki Hirose, Toshimitsu Kawai, Hiroki Oyama, Yumi Kuramoto
  • Patent number: 10895499
    Abstract: A spectrometer includes a light conduit configured to align scattered light scattered in a target by light output from a light source into a collimated beam, and a beam block configured to restrict an angle of the scattered light and detect the scattered light via the light conduit or the beam block through a filter array and a detector, thereby achieving miniaturization in a pen type or a flat plate shape while maintaining a spectral characteristic.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: January 19, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Youngzoon Yoon, Hyochul Kim, Younggeun Roh
  • Patent number: 10883926
    Abstract: A general-purpose optical measuring device enables at least measurement of a nucleic acid amplification amount; detection or quantitative measurement by a nucleic acid detection method, an immunoassay method, an enzyme method; or measurement of concentration or absorbance, and a method of the same. There are included a photometric content designation unit, an irradiation reception pair including an emission end that can emit measurement light, and a reception end that can receive light from the emission end, a photometric container that can store measurement target chemical substance solution, and includes a bottom portion having a formed translucent region, a nozzle communicated with a suction discharge mechanism of gas, a flow tube, an optical measurement unit, and a control unit configured to suck and hold the chemical substance solution into the flow tube, or store the chemical substance solution into the photometric container.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: January 5, 2021
    Assignee: UNIVERSAL BIO RESEARCH CO., LTD.
    Inventor: Hideji Tajima
  • Patent number: 10877256
    Abstract: An observation device includes an illuminating optical system that emits illuminating light obliquely upward from below a sample; and an objective optical system that images transmitted light, which is the illuminating light emitted from the illuminating optical system, reflected above the sample, and passed through the sample, the objective optical system imaging the transmitted light below the sample and via a different path from that of the illuminating optical system. The illuminating optical system includes a light source, a mask that restricts light, which is emitted from the light source, to a particular emission region, and a collimating optical system that converts the light restricted by the mask into substantially parallel light, and the illuminating optical system is arranged so that when the region is projected onto a pupil plane of the objective optical system, a projected image of the region partially overlaps a peripheral portion of the pupil.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: December 29, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Tadashi Hirata, Shintaro Takahashi
  • Patent number: 10837907
    Abstract: A multiple reaction parallel measurement apparatus is intended to measure a large number of reactions quickly, simply and with high accuracy. The apparatus includes: a plurality of light guiding paths corresponding to a plurality of reaction spot array elements, including a measuring end able to be in proximity of or in contact with each one of the reaction spots, and arranged to guide light generated by a reaction at the reaction spot to a connecting end; a measurement head arranged such that the measuring ends reach all together predetermined measurement positions of the corresponding reaction spots of the reaction spot array elements at a predetermined scan period; a light guiding path selector including a light guiding region optically connected to the connecting end; a light receiving unit; and a digital data converter to obtain digital data by converting image region data obtained from the light receiving unit.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: November 17, 2020
    Assignee: Universal Bio Research Co., Ltd.
    Inventor: Hideji Tajima
  • Patent number: 10834345
    Abstract: An imaging device may include an active silicon photomultiplier and associated temperature and non-uniformity compensation circuitry configured to mitigate temperature and process variations on the device. The compensation circuitry may include a reference silicon photomultiplier, a constant current source that supplies a fixed current into the reference silicon photomultiplier, a voltage sensor for detecting a voltage output from the reference silicon photomultiplier, a data converter for converting the voltage output from the voltage sensor, and a voltage controller for generating an adjustable voltage for biasing the active silicon photomultiplier depending on the signal output from the data converter.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 10, 2020
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventors: Brian Patrick McGarvey, Stephen John Bellis
  • Patent number: 10823951
    Abstract: A method for imaging in a microscope with oblique illumination includes illuminating an object by an illumination beam path that is obliquely incident on an object plane of the microscope. A microscopic image of the object and a corresponding digital image signal are produced. The digital image signal is processed by digital image processing using a convolution kernel to increase contrast. An increased-contrast digital image is produced from the processed digital image signal.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: November 3, 2020
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Benjamin Deissler, Albrecht Weiss, Alexander Weiss
  • Patent number: 10816483
    Abstract: A reticle inspection system and related method are disclosed. The system includes a concave spherical mirror positioned adjacent a side of the reticle that is configured to reflect inspection light transmitted through the reticle back towards and through the reticle. A sensor is configured to create at least one of: a first inspection image representative of a circuit pattern of the reticle based on transmission of the inspection light through the first side of the reticle and a reflection thereof by the concave spherical mirror through the second side of the reticle, and a second inspection image representative of the circuit pattern of the reticle based on the reflection of the inspection light from the first side of the reticle. A controller is configured to identify a defect in the reticle based on at least one of the first inspection image and the second inspection image.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: October 27, 2020
    Assignee: GlobalFoundries Inc.
    Inventors: Jed H. Rankin, Guoxiang Ning, Paul W. Ackmann, Jung-Yu Hsieh, Ming Lei
  • Patent number: 10801949
    Abstract: To perform more accurate analysis of a composition of a substance given at a sampling time, provided is an optical analysis apparatus, including: a flow passage, which is connected to a vessel, and is configured to allow a first substance to flow therethrough; an introduction unit, which is provided to the flow passage, and is configured to introduce at least two second substances to the flow passage, to thereby divide the first substance flowing through the flow passage; and a measurement unit, which is provided to the flow passage, and is configured to perform measurement by irradiating the first substance and the second substance flowing through the flow passage with light.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 13, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Toshimitsu Noguchi, Takuya Kambayashi, Shinichi Taniguchi
  • Patent number: 10790237
    Abstract: Each sensor in an array of sensors detects and signals when an edge of a wafer passes by the sensor on a wafer handling component of a robot. A number (N) of detected wafer edge locations is determined. Each detected wafer edge location is a set of coordinates (x, y) in a coordinate system of the wafer handling component. For each unique set of (N?1) of the number (N) of detected wafer edge locations, an estimated wafer offset is determined that substantially minimizes a performance index value. The estimated wafer offset is a vector extending from a center of the coordinate system of the wafer handling component to an estimated center location of the wafer. A final wafer offset is identified as the estimated wafer offset that has a smallest corresponding performance index value. The final wafer offset is used to center the wafer at a target station.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 29, 2020
    Assignee: Lam Research Corporation
    Inventors: Benjamin W. Mooring, Damon Tyrone Genetti
  • Patent number: 10782236
    Abstract: Various embodiments of the present technology may comprise a method and apparatus for a biosensor. The biosensor comprises a vertical flow channel that extends through a photodiode, and wherein the photodiode is lateral to the channel's vertical sidewall.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: September 22, 2020
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventors: Swarnal Borthakur, Ulrich Boettiger
  • Patent number: 10768108
    Abstract: A Surface Plasmon Resonance (SPR) biosensor system comprising: a SPR sensor surface, an illumination unit arranged to direct a wedge shaped beam of light at a line shaped detection area on the SPR sensor surface transverse to the direction of propagation of light, and a detection unit with detection optics for directing light reflected from the SPR sensor surface onto a two-dimensional optical detector unit such that the angle of reflection is imaged along one dimension and the width of the detection area along the other, wherein the illumination unit is arranged to selectively direct the wedge shaped beam of light at two or more spaced apart line shaped detection areas on the SPR sensor surface transverse to the direction of propagation of light.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: September 8, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Bengt Ivarsson, Stefan Sjolander
  • Patent number: 10746657
    Abstract: In a method for high-resolution scanning microscopy of a sample, provision is made of focusing of illumination radiation into an illumination spot in or on the sample and stimulating the emission of detection radiation at a sample spot that coincides with the illumination spot. The sample spot is imaged into an image that is static on a spatially resolving surface detector having pixels of a size that spatially resolve the image, wherein the imaging has a an optical imaging resolution limit. The entire sample is captured by performing a scanning movement of the illumination spot and of the coinciding sample spot over the sample in a scanning operation. An image of the sample having a resolution that is increased beyond the optical imaging resolution limit of the imaging is produced from the data of the pixels for each scanning position.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 18, 2020
    Assignee: Carl Zeiss Microscopy GmbH
    Inventor: Wolfgang Bathe
  • Patent number: 10746530
    Abstract: An optical metrology device includes an aperture that can be adjusted based on the thickness of the film on a sample. The aperture is adjusted to have a first aperture configuration or a second aperture configuration, where the second aperture configuration allows more light to pass. The aperture may be adjusted to use the second aperture configuration, e.g., if the thickness of the film produces a lateral shift from each internal reflection in the film at least 80% of the measurement spot size or the film thickness is greater than a predesignated amount, or if the light measured with the first aperture configuration and second aperture configuration differs by more than a predetermined threshold. The aperture may be in the source arm of the optical system, e.g., between the light source and the sample, or the receiver arm of the optical system, e.g., between the sample and the detector.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: August 18, 2020
    Assignee: ONTO INNOVATION INC.
    Inventor: Jeffrey T. Fanton
  • Patent number: 10746650
    Abstract: The reflection characteristic measuring device according to the present invention is a device that includes a diffuse reflecting surface and measures a plurality of mutually different types of reflection characteristics by using a plurality of optical systems having mutually different geometries, which corrects the reflection characteristics to be measured by an error generated when light emitted from an object of measurement is reflected from the diffuse reflecting surface and illuminates the object of measurement. The reflection characteristic measuring device according to the present invention is therefore capable of reducing errors resulting from recursive diffused illumination.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: August 18, 2020
    Assignee: Konica Minolta, Inc.
    Inventors: Toshio Kawano, Takashi Kawasaki
  • Patent number: 10682209
    Abstract: Embodiments for estimating a surface texture of a tooth are described herein. One method embodiment includes collecting a sequence of images utilizing multiple light conditions using an intra-oral imaging device and estimating the surface texture of the tooth based on the sequence of images.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 16, 2020
    Assignee: Align Technology, Inc.
    Inventor: Adi Levin
  • Patent number: 10663399
    Abstract: An optical analysis apparatus, that irradiates a liquid sample with light and analyzes the sample, includes a measurement unit that measures the sample, a light source portion that emits light with which the sample is irradiated, and a light receiving portion that receives the light transmitted through the sample. The measurement unit includes a housing provided with an opening portion for flowing in and out of the sample, an accommodation region connected to the opening portion and provided inside the housing, a movable portion provided inside the accommodation region to be movable inside the accommodation region, an irradiation portion which receives the light emitted from the light source portion and in which an inside of the accommodation region is irradiated with the light, and a light collection portion which collects the light transmitted through the sample inside the accommodation region and outputs the light to the light receiving portion.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: May 26, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Takuya Kanbayashi, Shinichi Taniguchi, Akihiro Nojima
  • Patent number: 10648898
    Abstract: Flow cytometer systems are provided having intermediate angle scatter detection capability. In some aspects, systems are provided that include an intermediate angle scatter (IAS) light detector positioned to measure intermediate angle scatter emitted from a flow cytometer. The system further includes a mask disposed across a portion of the IAS light detector and positioned between the flow cell and the IAS light detector to cover at least a central portion of the IAS light detector so as to block a diffraction pattern observed at the detector. In some instances, the diffraction pattern is created by a flat beam profile irradiating the sample. Methods are also provided for configuring a flow cytometer to block a diffraction pattern created by (1) a flat laser beam profile irradiating a flow cytometer liquid sample, or (2) a mismatched index of refraction between a sheath fluid and a liquid sample in a flow cytometer.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: May 12, 2020
    Assignee: Abbott Laboratories
    Inventor: Mahesh R. Junnarkar
  • Patent number: 10651221
    Abstract: An object of the invention is an image sensor comprising a matrix of pixels, extending along a detection plane, and configured to form an image of an incident light wave propagating in a spectral band along a propagation axis, the image sensor being characterized in that it comprises a mask, formed by opaque elementary masks, extending parallel to the detection plane, between which there extend openings through which the incident light wave can propagate toward the detection plane, the matrix of pixels being divided into: open pixels extending facing the openings; masked pixels, each masked pixel being defined by a projection of an elementary mask along the axis of propagation on the matrix of pixels, each masked pixel being associated with the elementary mask facing it; the image sensor comprising, between the open pixels and the openings: a waveguide, extending facing masked pixels and open pixels; a first diffraction grating, extending facing at least one open pixel, and configured to couple part of t
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: May 12, 2020
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Selimen Benahmed, Salim Boutami, Olivier Cioni
  • Patent number: 10641601
    Abstract: Disclosed herein is a simultaneous orthogonal scanning dual beam OCT system. The simultaneous orthogonal scanning dual beam OCT system includes: a light source 10; a light distribution unit 20; a sample arm 40; a reference arm 50; a interference unit 60; and a detection unit 70.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 5, 2020
    Assignee: Korea University Research and Business Foundation
    Inventors: Beop-Min Kim, Hyung-Jin Kim, Byeong-Joo Song
  • Patent number: 10633694
    Abstract: Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon. Under another aspect, a method includes providing a catalyst operable to cause a first chemiluminogenic molecule to emit a photon; providing a substrate; providing a first polynucleotide coupled to the substrate; hybridizing a second polynucleotide to the first polynucleotide; coupling a first quencher to a first nucleotide of the second polynucleotide; and inhibiting, by the first quencher, photon emission by the first chemiluminogenic molecule.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: April 28, 2020
    Assignee: Illumina, Inc.
    Inventors: Boyan Boyanov, Liangliang Qiang, Kevin L. Gunderson, Kay Klausing, Lea Pickering, Cyril Delattre, Tarun Khurana
  • Patent number: 10634560
    Abstract: A system is described that combines spectropolarimetry with scatterometry. The system uses an annular mirror and liquid crystal devices to control the angle of the incident light cone, the polarization and wavelength, an imaging setup and one or more video cameras so that spectroscopic-polarimetric-scatterometric images can be grabbed rapidly. The system is also designed to incorporate additional imaging modes such as interference, phase contrast, fluorescence and Raman spectropolarimetric imaging.
    Type: Grant
    Filed: October 7, 2018
    Date of Patent: April 28, 2020
    Inventor: Ibrahim Abdulhalim
  • Patent number: 10627348
    Abstract: An optical analysis apparatus, that irradiates a liquid sample with light and analyzes the sample, includes a measurement unit that measures the sample, a light source portion that emits light with which the sample is irradiated, and a light receiving portion that receives the light transmitted through the sample. The measurement unit includes a housing provided with an opening portion for flowing in and out of the sample, an accommodation region connected to the opening portion and provided inside the housing, a movable portion provided inside the accommodation region to be movable inside the accommodation region, an irradiation portion which receives the light emitted from the light source portion and in which an inside of the accommodation region is irradiated with the light, and a light collection portion which collects the light transmitted through the sample inside the accommodation region and outputs the light to the light receiving portion.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: April 21, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Takuya Kanbayashi, Shinichi Taniguchi, Akihiro Nojima
  • Patent number: 10563246
    Abstract: A microfluidic device and method for producing and collecting single droplets of a first fluid, the device including a microfluidic platform having at least a droplet microchannel wherein is produced a flow of single droplets of the first fluid dispersed in a second fluid immiscible with the first fluid, the droplet microchannel having at least one inlet extremity and at least one outlet extremity for distributing the flow of droplets, the device further including: a collection device including a plurality of receiving areas adapted to collect at least one of the droplets, elements for changing the relative position of the collection device and the outlet of the microfluidic platform, elements for controlling the flow of droplets, and elements for synchronizing the flow of droplets at the outlet of the droplet microchannel and the relative movement of the collection device with regards to the microfluidic platform.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: February 18, 2020
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Marie-Claude Potier, Patrick Tabeling, Luce Dauphinot, Nadege Bois, Fabrice Monti, Pascaline Mary
  • Patent number: 10514331
    Abstract: The system includes an adjustable light source constructed to direct a beam of electromagnetic radiation at a specimen chamber that allows a portion of the beam to scatter when illuminating particles within the chamber. The scattered portion of the beam is directed to a sensor, the sensor having a frame rate and a time period between frames. The system may have a processor connected to the sensor and light source, the processor may perform the following steps: activate the light source and obtain images from sensor; if the images from the sensor show that particles are blinking then reduce the frame rate, set the exposure time to at least 60% of the time between frames and reduce the illumination. Then, the processor obtains additional images and processes those images to mitigate blurring. The processor determines the Brownian motion of the particles from the processed images and determines the sizes of the particles based on the motion.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: December 24, 2019
    Assignee: HORIBA Instruments Incorporated
    Inventor: Jan J. Tatarkiewicz
  • Patent number: 10489906
    Abstract: A method of processing optical coherence tomography (OCT) scans through a subject's skin, the method comprising: receiving at least one OCT scan through the subject's skin, each scan representing an OCT signal in a slice through the subject's skin; processing each OCT scan so as to determine a set of parameters comprising at least a measure of the atrophy of the vascular structure in the epidermis; in which the processing produces a measurement of skin condition dependent upon each of the set of parameters, and the method comprises outputting the measurement of skin condition.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: November 26, 2019
    Assignee: Michelson Diagnostics Limited
    Inventors: Jonathan Denis Holmes, Richard Whitehead
  • Patent number: 10473905
    Abstract: A microscope having an observation beam path including a main objective, an OCT device including a first detection beam path, a wavefront measuring device including a second detection beam path, a first, a second and a third optics group is provided, wherein the first detection beam path contains the main objective and the first to third optics group, and the first to third optics group forms an afocal imaging optical unit of the first detection beam path and the second detection beam path contains the main objective, the first optics group and the second optics group, and the main objective and the first and second optics group form an afocal imaging optical unit of the second detection beam path.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 12, 2019
    Assignee: Carl Zeiss Meditec AG
    Inventors: Artur Hoegele, Franz Merz, Christian Beder, Andre Mueller, Daniel Kolster, Peter Reimer
  • Patent number: 10475712
    Abstract: A system is disclosed. The system includes a tool cluster. The tool cluster includes a first deposition tool configured to deposit a first layer on a wafer. The tool cluster additionally includes an interferometer tool configured to obtain one or more measurements of the wafer. The tool cluster additionally includes a second deposition tool configured to deposit a second layer on the wafer. The tool cluster additionally includes a vacuum assembly. One or more correctables configured to adjust at least one of the first deposition tool or the second deposition tool are determined based on the one or more measurements. The one or more measurements are obtained between the deposition of the first layer and the deposition of the second layer without breaking the vacuum generated by the vacuum assembly.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 12, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Ady Levy, Mark D. Smith
  • Patent number: 10470666
    Abstract: A photoacoustic apparatus includes a light irradiation unit configured to irradiate an object with light; a receiving unit configured to convert a photoacoustic wave generated from the object irradiated with the light from the light irradiation unit into an electric signal; an optical coefficient acquiring unit configured to acquire optical coefficient information of the object; a sound speed acquiring unit configured to acquire sound speed information of the object by using the optical coefficient information acquired by the optical coefficient acquiring unit; and an object information acquiring unit configured to acquire object information by using the electric signal and the sound speed information.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: November 12, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yoshiko Nakamura
  • Patent number: 10451483
    Abstract: A short wave infrared polarimeter comprising a pixelated polarizer array and an Indium-Gallium-Arsenide (“InGaAs”) focal plane array. The short wave infrared polarimeter optionally includes a micro-lens array and/or an aperture layer.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 22, 2019
    Assignee: Polaris Sensor Technologies, Inc.
    Inventor: J. Larry Pezzaniti