Plural Test Patents (Class 356/73)
  • Patent number: 10837907
    Abstract: A multiple reaction parallel measurement apparatus is intended to measure a large number of reactions quickly, simply and with high accuracy. The apparatus includes: a plurality of light guiding paths corresponding to a plurality of reaction spot array elements, including a measuring end able to be in proximity of or in contact with each one of the reaction spots, and arranged to guide light generated by a reaction at the reaction spot to a connecting end; a measurement head arranged such that the measuring ends reach all together predetermined measurement positions of the corresponding reaction spots of the reaction spot array elements at a predetermined scan period; a light guiding path selector including a light guiding region optically connected to the connecting end; a light receiving unit; and a digital data converter to obtain digital data by converting image region data obtained from the light receiving unit.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: November 17, 2020
    Assignee: Universal Bio Research Co., Ltd.
    Inventor: Hideji Tajima
  • Patent number: 10834345
    Abstract: An imaging device may include an active silicon photomultiplier and associated temperature and non-uniformity compensation circuitry configured to mitigate temperature and process variations on the device. The compensation circuitry may include a reference silicon photomultiplier, a constant current source that supplies a fixed current into the reference silicon photomultiplier, a voltage sensor for detecting a voltage output from the reference silicon photomultiplier, a data converter for converting the voltage output from the voltage sensor, and a voltage controller for generating an adjustable voltage for biasing the active silicon photomultiplier depending on the signal output from the data converter.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 10, 2020
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventors: Brian Patrick McGarvey, Stephen John Bellis
  • Patent number: 10823951
    Abstract: A method for imaging in a microscope with oblique illumination includes illuminating an object by an illumination beam path that is obliquely incident on an object plane of the microscope. A microscopic image of the object and a corresponding digital image signal are produced. The digital image signal is processed by digital image processing using a convolution kernel to increase contrast. An increased-contrast digital image is produced from the processed digital image signal.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: November 3, 2020
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Benjamin Deissler, Albrecht Weiss, Alexander Weiss
  • Patent number: 10816483
    Abstract: A reticle inspection system and related method are disclosed. The system includes a concave spherical mirror positioned adjacent a side of the reticle that is configured to reflect inspection light transmitted through the reticle back towards and through the reticle. A sensor is configured to create at least one of: a first inspection image representative of a circuit pattern of the reticle based on transmission of the inspection light through the first side of the reticle and a reflection thereof by the concave spherical mirror through the second side of the reticle, and a second inspection image representative of the circuit pattern of the reticle based on the reflection of the inspection light from the first side of the reticle. A controller is configured to identify a defect in the reticle based on at least one of the first inspection image and the second inspection image.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: October 27, 2020
    Assignee: GlobalFoundries Inc.
    Inventors: Jed H. Rankin, Guoxiang Ning, Paul W. Ackmann, Jung-Yu Hsieh, Ming Lei
  • Patent number: 10801949
    Abstract: To perform more accurate analysis of a composition of a substance given at a sampling time, provided is an optical analysis apparatus, including: a flow passage, which is connected to a vessel, and is configured to allow a first substance to flow therethrough; an introduction unit, which is provided to the flow passage, and is configured to introduce at least two second substances to the flow passage, to thereby divide the first substance flowing through the flow passage; and a measurement unit, which is provided to the flow passage, and is configured to perform measurement by irradiating the first substance and the second substance flowing through the flow passage with light.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 13, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Toshimitsu Noguchi, Takuya Kambayashi, Shinichi Taniguchi
  • Patent number: 10790237
    Abstract: Each sensor in an array of sensors detects and signals when an edge of a wafer passes by the sensor on a wafer handling component of a robot. A number (N) of detected wafer edge locations is determined. Each detected wafer edge location is a set of coordinates (x, y) in a coordinate system of the wafer handling component. For each unique set of (N?1) of the number (N) of detected wafer edge locations, an estimated wafer offset is determined that substantially minimizes a performance index value. The estimated wafer offset is a vector extending from a center of the coordinate system of the wafer handling component to an estimated center location of the wafer. A final wafer offset is identified as the estimated wafer offset that has a smallest corresponding performance index value. The final wafer offset is used to center the wafer at a target station.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 29, 2020
    Assignee: Lam Research Corporation
    Inventors: Benjamin W. Mooring, Damon Tyrone Genetti
  • Patent number: 10782236
    Abstract: Various embodiments of the present technology may comprise a method and apparatus for a biosensor. The biosensor comprises a vertical flow channel that extends through a photodiode, and wherein the photodiode is lateral to the channel's vertical sidewall.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: September 22, 2020
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventors: Swarnal Borthakur, Ulrich Boettiger
  • Patent number: 10768108
    Abstract: A Surface Plasmon Resonance (SPR) biosensor system comprising: a SPR sensor surface, an illumination unit arranged to direct a wedge shaped beam of light at a line shaped detection area on the SPR sensor surface transverse to the direction of propagation of light, and a detection unit with detection optics for directing light reflected from the SPR sensor surface onto a two-dimensional optical detector unit such that the angle of reflection is imaged along one dimension and the width of the detection area along the other, wherein the illumination unit is arranged to selectively direct the wedge shaped beam of light at two or more spaced apart line shaped detection areas on the SPR sensor surface transverse to the direction of propagation of light.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: September 8, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Bengt Ivarsson, Stefan Sjolander
  • Patent number: 10746657
    Abstract: In a method for high-resolution scanning microscopy of a sample, provision is made of focusing of illumination radiation into an illumination spot in or on the sample and stimulating the emission of detection radiation at a sample spot that coincides with the illumination spot. The sample spot is imaged into an image that is static on a spatially resolving surface detector having pixels of a size that spatially resolve the image, wherein the imaging has a an optical imaging resolution limit. The entire sample is captured by performing a scanning movement of the illumination spot and of the coinciding sample spot over the sample in a scanning operation. An image of the sample having a resolution that is increased beyond the optical imaging resolution limit of the imaging is produced from the data of the pixels for each scanning position.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 18, 2020
    Assignee: Carl Zeiss Microscopy GmbH
    Inventor: Wolfgang Bathe
  • Patent number: 10746650
    Abstract: The reflection characteristic measuring device according to the present invention is a device that includes a diffuse reflecting surface and measures a plurality of mutually different types of reflection characteristics by using a plurality of optical systems having mutually different geometries, which corrects the reflection characteristics to be measured by an error generated when light emitted from an object of measurement is reflected from the diffuse reflecting surface and illuminates the object of measurement. The reflection characteristic measuring device according to the present invention is therefore capable of reducing errors resulting from recursive diffused illumination.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: August 18, 2020
    Assignee: Konica Minolta, Inc.
    Inventors: Toshio Kawano, Takashi Kawasaki
  • Patent number: 10746530
    Abstract: An optical metrology device includes an aperture that can be adjusted based on the thickness of the film on a sample. The aperture is adjusted to have a first aperture configuration or a second aperture configuration, where the second aperture configuration allows more light to pass. The aperture may be adjusted to use the second aperture configuration, e.g., if the thickness of the film produces a lateral shift from each internal reflection in the film at least 80% of the measurement spot size or the film thickness is greater than a predesignated amount, or if the light measured with the first aperture configuration and second aperture configuration differs by more than a predetermined threshold. The aperture may be in the source arm of the optical system, e.g., between the light source and the sample, or the receiver arm of the optical system, e.g., between the sample and the detector.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: August 18, 2020
    Assignee: ONTO INNOVATION INC.
    Inventor: Jeffrey T. Fanton
  • Patent number: 10682209
    Abstract: Embodiments for estimating a surface texture of a tooth are described herein. One method embodiment includes collecting a sequence of images utilizing multiple light conditions using an intra-oral imaging device and estimating the surface texture of the tooth based on the sequence of images.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 16, 2020
    Assignee: Align Technology, Inc.
    Inventor: Adi Levin
  • Patent number: 10663399
    Abstract: An optical analysis apparatus, that irradiates a liquid sample with light and analyzes the sample, includes a measurement unit that measures the sample, a light source portion that emits light with which the sample is irradiated, and a light receiving portion that receives the light transmitted through the sample. The measurement unit includes a housing provided with an opening portion for flowing in and out of the sample, an accommodation region connected to the opening portion and provided inside the housing, a movable portion provided inside the accommodation region to be movable inside the accommodation region, an irradiation portion which receives the light emitted from the light source portion and in which an inside of the accommodation region is irradiated with the light, and a light collection portion which collects the light transmitted through the sample inside the accommodation region and outputs the light to the light receiving portion.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: May 26, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Takuya Kanbayashi, Shinichi Taniguchi, Akihiro Nojima
  • Patent number: 10648898
    Abstract: Flow cytometer systems are provided having intermediate angle scatter detection capability. In some aspects, systems are provided that include an intermediate angle scatter (IAS) light detector positioned to measure intermediate angle scatter emitted from a flow cytometer. The system further includes a mask disposed across a portion of the IAS light detector and positioned between the flow cell and the IAS light detector to cover at least a central portion of the IAS light detector so as to block a diffraction pattern observed at the detector. In some instances, the diffraction pattern is created by a flat beam profile irradiating the sample. Methods are also provided for configuring a flow cytometer to block a diffraction pattern created by (1) a flat laser beam profile irradiating a flow cytometer liquid sample, or (2) a mismatched index of refraction between a sheath fluid and a liquid sample in a flow cytometer.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: May 12, 2020
    Assignee: Abbott Laboratories
    Inventor: Mahesh R. Junnarkar
  • Patent number: 10651221
    Abstract: An object of the invention is an image sensor comprising a matrix of pixels, extending along a detection plane, and configured to form an image of an incident light wave propagating in a spectral band along a propagation axis, the image sensor being characterized in that it comprises a mask, formed by opaque elementary masks, extending parallel to the detection plane, between which there extend openings through which the incident light wave can propagate toward the detection plane, the matrix of pixels being divided into: open pixels extending facing the openings; masked pixels, each masked pixel being defined by a projection of an elementary mask along the axis of propagation on the matrix of pixels, each masked pixel being associated with the elementary mask facing it; the image sensor comprising, between the open pixels and the openings: a waveguide, extending facing masked pixels and open pixels; a first diffraction grating, extending facing at least one open pixel, and configured to couple part of t
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: May 12, 2020
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Selimen Benahmed, Salim Boutami, Olivier Cioni
  • Patent number: 10641601
    Abstract: Disclosed herein is a simultaneous orthogonal scanning dual beam OCT system. The simultaneous orthogonal scanning dual beam OCT system includes: a light source 10; a light distribution unit 20; a sample arm 40; a reference arm 50; a interference unit 60; and a detection unit 70.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 5, 2020
    Assignee: Korea University Research and Business Foundation
    Inventors: Beop-Min Kim, Hyung-Jin Kim, Byeong-Joo Song
  • Patent number: 10634560
    Abstract: A system is described that combines spectropolarimetry with scatterometry. The system uses an annular mirror and liquid crystal devices to control the angle of the incident light cone, the polarization and wavelength, an imaging setup and one or more video cameras so that spectroscopic-polarimetric-scatterometric images can be grabbed rapidly. The system is also designed to incorporate additional imaging modes such as interference, phase contrast, fluorescence and Raman spectropolarimetric imaging.
    Type: Grant
    Filed: October 7, 2018
    Date of Patent: April 28, 2020
    Inventor: Ibrahim Abdulhalim
  • Patent number: 10633694
    Abstract: Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon. Under another aspect, a method includes providing a catalyst operable to cause a first chemiluminogenic molecule to emit a photon; providing a substrate; providing a first polynucleotide coupled to the substrate; hybridizing a second polynucleotide to the first polynucleotide; coupling a first quencher to a first nucleotide of the second polynucleotide; and inhibiting, by the first quencher, photon emission by the first chemiluminogenic molecule.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: April 28, 2020
    Assignee: Illumina, Inc.
    Inventors: Boyan Boyanov, Liangliang Qiang, Kevin L. Gunderson, Kay Klausing, Lea Pickering, Cyril Delattre, Tarun Khurana
  • Patent number: 10627348
    Abstract: An optical analysis apparatus, that irradiates a liquid sample with light and analyzes the sample, includes a measurement unit that measures the sample, a light source portion that emits light with which the sample is irradiated, and a light receiving portion that receives the light transmitted through the sample. The measurement unit includes a housing provided with an opening portion for flowing in and out of the sample, an accommodation region connected to the opening portion and provided inside the housing, a movable portion provided inside the accommodation region to be movable inside the accommodation region, an irradiation portion which receives the light emitted from the light source portion and in which an inside of the accommodation region is irradiated with the light, and a light collection portion which collects the light transmitted through the sample inside the accommodation region and outputs the light to the light receiving portion.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: April 21, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Takuya Kanbayashi, Shinichi Taniguchi, Akihiro Nojima
  • Patent number: 10563246
    Abstract: A microfluidic device and method for producing and collecting single droplets of a first fluid, the device including a microfluidic platform having at least a droplet microchannel wherein is produced a flow of single droplets of the first fluid dispersed in a second fluid immiscible with the first fluid, the droplet microchannel having at least one inlet extremity and at least one outlet extremity for distributing the flow of droplets, the device further including: a collection device including a plurality of receiving areas adapted to collect at least one of the droplets, elements for changing the relative position of the collection device and the outlet of the microfluidic platform, elements for controlling the flow of droplets, and elements for synchronizing the flow of droplets at the outlet of the droplet microchannel and the relative movement of the collection device with regards to the microfluidic platform.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: February 18, 2020
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Marie-Claude Potier, Patrick Tabeling, Luce Dauphinot, Nadege Bois, Fabrice Monti, Pascaline Mary
  • Patent number: 10514331
    Abstract: The system includes an adjustable light source constructed to direct a beam of electromagnetic radiation at a specimen chamber that allows a portion of the beam to scatter when illuminating particles within the chamber. The scattered portion of the beam is directed to a sensor, the sensor having a frame rate and a time period between frames. The system may have a processor connected to the sensor and light source, the processor may perform the following steps: activate the light source and obtain images from sensor; if the images from the sensor show that particles are blinking then reduce the frame rate, set the exposure time to at least 60% of the time between frames and reduce the illumination. Then, the processor obtains additional images and processes those images to mitigate blurring. The processor determines the Brownian motion of the particles from the processed images and determines the sizes of the particles based on the motion.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: December 24, 2019
    Assignee: HORIBA Instruments Incorporated
    Inventor: Jan J. Tatarkiewicz
  • Patent number: 10489906
    Abstract: A method of processing optical coherence tomography (OCT) scans through a subject's skin, the method comprising: receiving at least one OCT scan through the subject's skin, each scan representing an OCT signal in a slice through the subject's skin; processing each OCT scan so as to determine a set of parameters comprising at least a measure of the atrophy of the vascular structure in the epidermis; in which the processing produces a measurement of skin condition dependent upon each of the set of parameters, and the method comprises outputting the measurement of skin condition.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: November 26, 2019
    Assignee: Michelson Diagnostics Limited
    Inventors: Jonathan Denis Holmes, Richard Whitehead
  • Patent number: 10473905
    Abstract: A microscope having an observation beam path including a main objective, an OCT device including a first detection beam path, a wavefront measuring device including a second detection beam path, a first, a second and a third optics group is provided, wherein the first detection beam path contains the main objective and the first to third optics group, and the first to third optics group forms an afocal imaging optical unit of the first detection beam path and the second detection beam path contains the main objective, the first optics group and the second optics group, and the main objective and the first and second optics group form an afocal imaging optical unit of the second detection beam path.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 12, 2019
    Assignee: Carl Zeiss Meditec AG
    Inventors: Artur Hoegele, Franz Merz, Christian Beder, Andre Mueller, Daniel Kolster, Peter Reimer
  • Patent number: 10470666
    Abstract: A photoacoustic apparatus includes a light irradiation unit configured to irradiate an object with light; a receiving unit configured to convert a photoacoustic wave generated from the object irradiated with the light from the light irradiation unit into an electric signal; an optical coefficient acquiring unit configured to acquire optical coefficient information of the object; a sound speed acquiring unit configured to acquire sound speed information of the object by using the optical coefficient information acquired by the optical coefficient acquiring unit; and an object information acquiring unit configured to acquire object information by using the electric signal and the sound speed information.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: November 12, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yoshiko Nakamura
  • Patent number: 10475712
    Abstract: A system is disclosed. The system includes a tool cluster. The tool cluster includes a first deposition tool configured to deposit a first layer on a wafer. The tool cluster additionally includes an interferometer tool configured to obtain one or more measurements of the wafer. The tool cluster additionally includes a second deposition tool configured to deposit a second layer on the wafer. The tool cluster additionally includes a vacuum assembly. One or more correctables configured to adjust at least one of the first deposition tool or the second deposition tool are determined based on the one or more measurements. The one or more measurements are obtained between the deposition of the first layer and the deposition of the second layer without breaking the vacuum generated by the vacuum assembly.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 12, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Ady Levy, Mark D. Smith
  • Patent number: 10451483
    Abstract: A short wave infrared polarimeter comprising a pixelated polarizer array and an Indium-Gallium-Arsenide (“InGaAs”) focal plane array. The short wave infrared polarimeter optionally includes a micro-lens array and/or an aperture layer.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 22, 2019
    Assignee: Polaris Sensor Technologies, Inc.
    Inventor: J. Larry Pezzaniti
  • Patent number: 10423124
    Abstract: In the present invention a new atomic clock is proposed comprising: at least one light source adapted to provide an optical beam, at least one photo detector and a vapor cell comprising a first optical window, said optical beam being directed through said vapor cell for providing an optical frequency reference signal, said photo detector being adapted to detect said optical frequency reference signal and to generate at least one reference signal, wherein—said atomic clock comprises a first optical waveguide arranged to said first optical window, said first optical waveguide being arranged to incouple at least a portion of said optical beam, said first optical waveguide being sized and shaped so that said first guided light beam is expanded, a first outcoupler is arranged to outcouple at least a portion of said guided light beam to said vapor cell, —the thickness t of the atomic clock is smaller than 15 nm.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: September 24, 2019
    Assignee: CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA—RECHERCHE ET DÉVELOPPEMENT
    Inventors: Benjamin Gallinet, Jacques Haesler, Steve Lecomte, Guillaume Basset
  • Patent number: 10416060
    Abstract: A system for calculating the volume of a plurality of particles is disclosed. The system includes three optical assemblies, each with a light source directing a beam of light of a wavelength along an optical axis at a specimen chamber, a filter positioned along the optical path after the chamber, and a sensor positioned along the optical path after the filter. The wavelength of each beam of light is different from the other wavelengths, and each optical axis is orthogonal to the other optical axes. A processor is connected to the sensors in each of the optical assemblies, and the processors perform the following steps: (a) capture an image from each of the three sensors; (b) based on the images, calibrate each sensor; (c) after calibration, capture an image from each of the three sensors; and (d) determine a volume of the plurality of particles, based on the images captured in step (c).
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 17, 2019
    Assignee: HORIBA INSTRUMENTS INCORPORATED
    Inventors: Jan J. Tatarkiewicz, Miroslav Pejcinovic
  • Patent number: 10408606
    Abstract: An inspection system for measuring an object is provided. The inspection system includes an entryway sized to receive the object. At least two non-contact coordinate measurement devices are positioned with a field of view being at least partially within or adjacent to the entryway, each of the at least two non-contact coordinate measurement devices being operable to measure 3D coordinates for a plurality of points on the object as one of the object or the entryway move from a first position to a final position. A pose measurement device is operable to determine the six-degree of freedom (6DOF) pose of the object. One or more processors are provided that register the 3D coordinates for the plurality of points from each of the at least two non-contact coordinate measurement devices based at least in part on the 6DOF pose of the object.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: September 10, 2019
    Assignee: FARO TECHNOLOGIES, INC.
    Inventors: Simon Raab, Bernd-Dietmar Becker, Rolf Heidemann, Steffen Kappes, João Santos, Oliver Zweigle, Aleksej Frank
  • Patent number: 10380448
    Abstract: Scanners, methods, and computer storage media having computer-executable instructions embodied thereon that process variable sized objects with high package pitch on a moving conveyor belt are provided. The scanners include a substrate and a plurality of sensors attached to the substrate. The plurality of sensors forms an array of sensors having at least two or more rows of off-axis sensors. The sensors may include a one or more area array sensors. The arrays of sensors captures moving objects row by row and are optimized reduce object spacing on the conveyor belt. Additionally, the scanner having the array of sensor may process different objects having different heights at the same time. Accordingly, object throughput on the conveyor belt is increased by reducing minimum object gap (e.g., processing of “no gap” or non-singulated objects).
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: August 13, 2019
    Assignee: Datalogic USA, Inc.
    Inventors: Xinping Liu, Andrew Hatstat, Federico Canini, Pietro Todescato, Wenliang Gao
  • Patent number: 10376151
    Abstract: Provided is an object information acquiring apparatus including: a light source; a controller that controls irradiation of light from the light source; a detector that receives an acoustic wave generated from an object onto which light from the light source is irradiated; a processor that generates characteristic information inside the object using the acoustic wave received by the detector; and an acquirer that acquires the shape of the object, wherein the controller controls an irradiation area when light is irradiated from the light source onto the object, based on the shape of the object acquired by the acquirer.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: August 13, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Yasufumi Asao, Takuji Oishi
  • Patent number: 10359363
    Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: July 23, 2019
    Assignee: IMEC VZW
    Inventors: Peter Peumans, Liesbet Lagae, Willem Van Roy, Tim Stakenborg, Pol Van Dorpe
  • Patent number: 10350037
    Abstract: A method for intraoral imaging acquires structured light images from a region of interest and forms a range image that characterizes the surface contour of the region of interest according to the acquired structured light images. At least one row of pixels in the range image is processed by selecting a segment of the row, computing residual noise in the selected segment, generating a template for the segment, wherein the template is characteristic of an imaging artifact related to motion, computing a similarity factor according to correlation between frequency-domain transforms of the template and computed residual noise and comparing the computed similarity factor against a threshold to identify an image artifact. The image artifact or excessive motion are reported.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: July 16, 2019
    Assignee: Carestream Dental Technology Topco Limited
    Inventors: Yanbin Lu, Dawei Sun, Qinran Chen
  • Patent number: 10352868
    Abstract: A grading lamp for gemstones is disclosed. In one embodiment, the grading lamp includes a base having an open top with a bottom wall bounded by upstanding front, rear, and side walls, and a lid hinged to the rear wall for swinging between open, intermediate, and closed positions relative to the base. The lid includes an interior lamp recess having natural and ultraviolet lights behind a light diffusing filter. A tray within the open top of the base holds color reference stones and a gem under examination. In the intermediate position, the grading lamp mitigates outside ambient light and provides direct light from either the natural or ultraviolet lights.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: July 16, 2019
    Assignee: Sy Kessler Sales, Inc.
    Inventors: Daniel L. Kessler, Henry M. Kessler
  • Patent number: 10345307
    Abstract: Among others, the present invention provides devices each including a micro-filter, a shutter, a cell counter, a selector, a micro-surgical kit, a timer, and a data processing circuitry, wherein the micro-filter is capable of detecting or filtering circulating tumor cells.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: July 9, 2019
    Assignee: ANPAC BIO-MEDICAL SCIENCE CO., LTD.
    Inventors: Chris C. Yu, Xuedong Du, He Yu
  • Patent number: 10345214
    Abstract: The method enables a concentration of a species in a culture medium (12) to be estimated using an estimation system (10) comprising a light source (16), a transparent substrate (14) and a matrix photodetector (18), the substrate being located between the source and the photodetector, the medium comprising biological particles (32) and changing color when said concentration varies. Said method comprises the following steps:—placing the medium on the substrate,—illuminating the medium via the light source,—acquisition of an image of the medium via the photodetector, each image being formed by a ray transmitted by the illuminated medium and comprising at least one diffraction pattern, each diffraction pattern corresponding to the waves diffracted by a biological particle when the medium is illuminated,—and calculating an estimate of said concentration as a function of a pixel intensity of the acquired image.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 9, 2019
    Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventor: Jean-Guillaume Coutard
  • Patent number: 10337995
    Abstract: A method for constructing a three-dimensional image of a sample includes producing electromagnetic radiation and directing the produced electromagnetic radiation such that it is incident on the sample at an oblique angle. The incident electromagnetic radiation is scanned in discrete increments to a plurality of discrete locations along a first direction, and at each discrete location, scanned along a second direction orthogonal to the first direction. The sample reflects a first portion of the incident electromagnetic radiation and absorbs a second portion of the incident electromagnetic radiation, and emits electromagnetic radiation responsive to the absorption. A plurality of cross-sectional images is produced from the reflected electromagnetic radiation and the emitted electromagnetic radiation, and each cross-sectional image is modified to compensate for the oblique angle. The modified cross-sectional images are then combined to create a three-dimensional image of the sample.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: July 2, 2019
    Assignee: BOSTON MEDICAL CENTER CORPORATION
    Inventor: Ji Yi
  • Patent number: 10306092
    Abstract: This disclosure provides a self-contained imaging device that takes digital photographs of portions of documents (such as photos or photo albums) instead of scanning those images. The imaging device uses a lens to zoom in on specific portions of the document that represent images that are to be digitized. Generally speaking, disclosed embodiments utilize a physical device having a housing, a location for retaining or holding an image to be imaged, such as a platen or image conveyance mechanism, a light source and the imaging system (which can be a digital camera). The disclosed device camera provides a low-cost mechanism that can at-once capture a high resolution image without the delays associated with most scanners.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 28, 2019
    Assignee: YesVideo, Inc.
    Inventors: Sai-Wai Fu, Rolf Breuer, Christian Collins, Cris Delos Reyes, Eric Muzzi
  • Patent number: 10302610
    Abstract: To analyze a generation source of a target component emitted in a form of a gas. To provide a generation source analyzing device comprising an acquiring section which acquires a concentration measurement value of a gas which includes a target component, and a concentration measurement value of a particle component which is generated in association with the gas, and an analyzing section which analyzes a distance from a measurement point to a generation source of the target component based on a concentration measurement value of the gas and a concentration measurement value of the particle component. The acquiring section may acquire a concentration measurement value of a precursor gas which becomes a raw material which generates the particle component, and a concentration measurement value of a secondary generated particle component which is generated from the precursor gas.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: May 28, 2019
    Assignee: FUJI ELECTRIC CO., LTD.
    Inventors: Naoki Takeda, Yoshiki Hasegawa, Kazuhiro Koizumi, Bo Li
  • Patent number: 10288719
    Abstract: An object information acquiring apparatus, comprises a light irradiating unit configured to irradiate an object with light; a probe configured to receive an acoustic wave generated from the object and convert into an electrical signal; a characteristic information acquiring unit configured to acquire characteristic information relating to the object based on the electrical signal; an area information acquiring unit configured to acquire information relating to a reachable area of the light; a location detecting unit configured to acquire an operator location; and a determining unit configured to determine whether the operator location is in a first state where the operator location overlaps with the reachable area of the light or a second state where the operator location does not overlap with the reachable area of the light.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: May 14, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Mie Okano, Yohei Hashizume, Yasufumi Asao
  • Patent number: 10274312
    Abstract: A system and device that measures a specimen's surface profile by passing a bright white light source through a series of lenses which generate repeatable chromatic focal shift variations of wavelengths of white light for Z axis measurements. The movement of the sensor along an X-Y raster pattern is controlled by a X-directional and Y-directional scanner used in combination with X and Y actuators. The system and device translate the chromatic focal shifts into digital data which may then be used to both control the position of the lenses along the surface of the specimen and generate a 3D topographical images of the specimens being profiled.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: April 30, 2019
    Assignee: Nanovea, Inc.
    Inventors: Pierre Leroux, Fernando Valenzuela, Curt Deckert
  • Patent number: 10274367
    Abstract: The effective spot size of a spectroscopic metrology device is reduced through deconvolution of a measurement spectra set acquired from a measurement target combined with a training spectra set obtained from a training target. The measurement spectra set may be obtained using sparse sampling of a grid scan of a measurement target. The training spectra set is obtained from a grid scan of a training target that is similar to the measurement target. The training spectra set and the measurement spectra set include spectra from different grid nodes. Deconvolution of the measurement spectra and the training spectra sets produces an estimated spectrum for the measurement target that is an estimate of a spectrum from the measurement target produced with incident light having an effective spot size that is smaller than the actual spot size. One or more characteristics of the measurement target may then be determined using the estimated spectrum.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: April 30, 2019
    Assignee: Nanometrics Incorporated
    Inventors: Amit Shachaf, Pedro Vagos, Michael Elad
  • Patent number: 10267736
    Abstract: Methods, systems, and devices are disclosed for imaging particles and/or cells using flow cytometry. In one aspect, a method includes transmitting a light beam at a fluidic channel carrying a fluid sample containing particles; optically encoding scattered or fluorescently-emitted light at a spatial optical filter, the spatial optical filter including a surface having a plurality of apertures arranged in a pattern along a transverse direction opposite to particle flow and a longitudinal direction parallel to particle flow, such that different portions of a particle flowing over the pattern of the apertures pass different apertures at different times and scatter the light beam or emit fluorescent light at locations associated with the apertures; and producing image data associated with the particle flowing through the fluidic channel based on the encoded optical signal, in which the produced image data includes information of a physical characteristic of the particle.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 23, 2019
    Assignee: The Regents of the University of California
    Inventors: Yu-Hwa Lo, Yuanyuan Han
  • Patent number: 10251239
    Abstract: Embodiments of the present disclosure disclose an illuminating device, a control method thereof and a control system thereof, which can precisely adjust the color of irradiating light according to the color of an object. In the embodiment of the present disclosure, a next detection light is obtained according to reflected light of a previous detection light. When the color difference of reflected light of the previous detection light and the next detection light is less than a preset color difference range, the illuminating device is controlled to project the next detection light to an illuminated object.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: April 2, 2019
    Assignee: OPPLE LIGHTING CO., LTD.
    Inventors: Juan Bian, Jie He, Yang Hu, Jian Wang, Liang Wang, Wei Wen, Wanghui Yan, Tianhang Zheng, Zhixian Zhou
  • Patent number: 10234392
    Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: March 19, 2019
    Assignee: ACEA Biosciences, Inc.
    Inventors: Nan Li, Ye Chen, Hyunsun Chung, Zengqiang Li, Xiaobo Wang
  • Patent number: 10230459
    Abstract: A system for testing continuity of a cable assembly includes an optical time domain reflectometry (OTDR) device selectively coupled to an input connector of a cable and a design database storing cable data. The cable data indicates at least a length of the cable. The system includes a processor and memory in communication with the processor. The processor is configured to execute instructions stored on the memory which cause the processor to receive the cable data from the design database, receive OTDR data associated with the cable from the OTDR device, and calculate a distance-to-fault based on the OTDR data. In response to the distance-to-fault being less than the length of the cable, the processor determines that a connectivity failure has occurred with the cable and generates fault data indicating the connectivity failure.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: March 12, 2019
    Assignee: THE BOEING COMPANY
    Inventors: Brandon M. Courter, Nam V. Ngo, Scott C Farner, Joseph M. Dray
  • Patent number: 10222315
    Abstract: Holograms of colloidal dispersions encode comprehensive information about individual particles' three-dimensional positions, sizes and optical properties. Extracting that information typically is computation-ally intensive, and thus slow. Machine-learning techniques based on support vector machines (SVMs) can analyze holographic video microscopy data in real time on low-power computers. The resulting stream of precise particle-resolved tracking and characterization data provides unparalleled insights into the composition and dynamics of colloidal dispersions and enables applications ranging from basic research to process control and quality assurance.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: March 5, 2019
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, Aaron Yevick, Mark Hannel
  • Patent number: 10197443
    Abstract: An optical calibration method for a spectrum measurement device including a light-input part includes: measuring a plurality of narrow-band rays by the light-input part to obtain a plurality of narrow-band spectrum impulse responses, respectively; establishing a stray light database according to the narrow-band spectrum impulse responses; generating a correction program according to the stray light database; measuring a spectral radiant standard light by the light-input part to obtain measurement spectrum data; and generating a calibration coefficient program based on the measurement spectrum data and spectral radiant standard spectrum data, wherein the calibration coefficient program matches the measurement spectrum data with the spectral radiant standard spectrum data, and the spectral radiant standard spectrum data is obtained by measuring the spectral radiant standard light by a standard spectrum measurement device.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: February 5, 2019
    Assignee: OTO PHOTONICS INC.
    Inventors: Chien-Hsiang Hung, Sheng-Wang Lin, Hsu-Feng Cheng
  • Patent number: 10190971
    Abstract: The present invention relates to a method for analyzing the color of a color alloy and, more particularly, to a method for analyzing the color of a color alloy wherein, on the basis of the fact that a different color appears according to the composition of an alloy, the wavelength-wise reflectance related to a color, which is held according to each alloy composition, and that related to a color, which is held by a measurement object that is to be measured, are compared, thereby determining the color held by the measurement object.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: January 29, 2019
    Assignee: Korea Institute of Industrial Technology
    Inventors: Hyo Soo Lee, Hyouk Chon Kwon, Hai Joong Lee, Heong Won Shin
  • Patent number: 10182772
    Abstract: Systems and methods described herein generally relate to object detection for nuclear medicine (NM) imaging. The systems and methods acquire triplets representing line of sights between a plurality of receive diodes and light emitting diodes (LEDs) positioned along a circumference of a gantry with respect to one or more objects of a patient. The systems and methods identify a number of the one or more objects based on a number of triplets for one of the LEDs. When a single object is identified, the systems and methods determine a shape of the single object based on a reference point within the single object and line of sights adjacent to the single object. Alternatively, when a plurality of objects are identified, the systems and methods utilize the line of sights to identify shapes of the plurality of objects.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: January 22, 2019
    Assignee: General Electric Company
    Inventors: Elad Rotman, Ilan Levin