Abstract: A method for improving an identification accuracy of mixture components by using a known mixture Raman spectrum is disclosed. After calculating a first similarity between a to-be-tested Raman spectrum characteristic vector group and a pure substance Raman spectrum characteristic vector group of an nth kind of pure substance in a Raman spectrum standard library, the method uses a known mixture library to calculate to obtain a second similarity between a to-be-identified substance Raman spectrum characteristic vector group and a spectral peak characteristic vector group with offset information corresponding to a pure substance in a known mixture, and determines a similarity between a to-be-tested mixture and the nth kind of pure substance according to the first similarity and all second similarities to thus obtain a component identification result. The present application uses the known mixture library to assist the Raman spectrum standard library in searching.

Abstract: Systems having an unfiltered light scatter detector configured to detect scattered light from a sample in a flow stream are provided. Systems according to certain embodiments include a light source having two or more lasers, a light detection system having an unfiltered light scatter detector and a processor having memory operably coupled to the processor where the memory includes instructions which when executed by the processor, cause the processor to generate one or more data signals in response to scattered light from each of the two or more lasers detected by the unfiltered light scatter detector; and determine one or more parameters of data acquisition based on the generated data signals from the unfiltered light scatter detector. Methods for determining one or more parameters for data acquisition with the subject systems are also described.

Abstract: A system and method for estimating road conditions ahead of a vehicle, including: a LIDAR sensor operable for generating a LIDAR point cloud; a processor executing a road condition estimation algorithm stored in a memory, the road condition estimation algorithm performing the steps including: detecting a ground plane or drivable surface in the LIDAR point cloud; superimposing an M×N matrix on at least a portion of the LIDAR point cloud; for each patch of the LIDAR point cloud defined by the M×N matrix, statistically evaluating a relative position, a feature elevation, and a scaled reflectance index; and, from the statistically evaluated relative position, feature elevation, and scaled reflectance index, determining a slipperiness probability for each patch of the LIDAR point cloud; and a vehicle control system operable for, based on the determined slipperiness probability for each patch of the LIDAR point cloud, affecting an operation of the vehicle.

Abstract: In a range imaging camera, a first range image producing unit produces a first range image by calculating a distance to an object on the basis of the delay time or the received light amount of each pixel produced by a light receiving processing unit. A second range image producing unit produces a second range image by performing filtering for each pixel of the first range image using a group of neighboring pixels including its own pixel. In this case, a pixel group selection unit selects a group of pixels used in the filtering such that at least one of produced values including the delay time and the received light amount produced by the light receiving processing unit and the first range image produced by the first range image producing unit is equal to or larger than a noise component value.

Abstract: An optoelectronic measuring device having scanning functionality having a pulsed radiation source for generating a measuring beam from light pulses at a light pulse emission rate, an optoelectronic detector for detecting light pulses reflected from a target object, a control and analysis unit designed for measuring a distance value from a respective scanning point of the target object according to the time-of-flight principle, based on a number n>=1 of light pulses, wherein the control and analysis unit is designed to automatically set the number (n) depending on a target-object-related measured value determined by the measuring device in real time.

Abstract: Systems and techniques for determining and correcting inter-wafer misalignments in a stack of wafers transported by a wafer handling robot. An enhanced automatic wafer centering system is provided that may be used to determine a smallest circle associated with the stack of wafers, which may then be used to determine whether or not the stack of wafer meets various process requirements and/or if a centering correction can be made to better align the wafers with a receiving station coordinate frame.

Abstract: A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.

Abstract: Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

Abstract: A method and apparatus are provided. In an example, a volume portion of the solid body is exposed to light waves of different wavelengths, wherein the light waves are partly reflected at surfaces of the solid body. Light parameters of the reflected light waves are at least partly acquired using a sensor device. Distance information and/or intensity information are/is ascertained from at least a portion of the acquired light parameters. A thickness and/or a transmittance of the solid body in the volume portion are/is determined based upon the distance information and/or the intensity information. Laser radiation is introduced into the volume portion to produce a modification in the interior of the solid body, wherein at least one laser parameter of the laser radiation is set at least depending on the thickness and/or the transmittance such that the modification is at a predefined distance from a surface of the solid body.

Abstract: Methods and apparatus for classifying and/or discriminating particles in an aerosol. An example method involves delivering a flow of the aerosol through a nozzle into a sampling volume and directing a plurality of light beams onto an interaction plane in the sampling volume. The plurality of light beams may each be made up of light having one of a corresponding plurality of different wavelengths. For example, the wavelengths may include wavelengths of visible and infrared light or visible, near infrared and short wave infrared light. The method may detect intensities of light from the plurality of light beams that has been scattered at the interaction plane by particles of the aerosol at a plurality of different scattering angles. The resulting data is processed to characterize and/or discriminate the particles.

Abstract: Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

Abstract: Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

Abstract: Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

Abstract: One variation of a method for detecting pathogens in an environment includes, during a first sampling period: triggering collection of a pathogen sample from ambient air in the environment by an air sampler; and tracking a first organic load of the first pathogen sample via a detection subsystem integrated within the air sampler, the first organic load representative of a first amount of organic matter present in the first pathogen sample. In response to the first organic load exceeding a threshold organic load defined for the environment, the method further includes: interpreting presence of a set of pathogens in the environment via genetic analysis of the first pathogen sample; and, in response to detecting presence of a first pathogen, in the set of pathogens, in the first pathogen sample, transmitting a notification indicating presence of the first pathogen in the environment to a user associated with the environment.

Abstract: The present invention relates to a method for determining an analyte using surface enhanced RAMAN spectroscopy and to a device which is suitable for this purpose.

Abstract: A distance measuring device for measuring the distance to an object is provided, including a light-emitting module, a driving assembly disposed in the light-emitting module, and a light-receiving module. The light-emitting module has a housing, a light source disposed in the housing, a light grating element, and an optical path adjuster. The light source emits a measuring light through the optical path adjuster and the light grating element. The driving assembly can drive the optical path adjuster or the light grating element to move relative to the housing. The light-receiving module receives the measuring light which is reflected by the object to obtain distance information of the object.

Abstract: A light sheet microscope includes a sample chamber in which a cover slip or slide is arrangeable, which has a surface that defines a partially reflective interface and which has a further surface that defines a further partially reflective interface. The two interfaces are arranged at different distances from an objective. The light sheet microscope further includes an optical system having the objective facing toward the cover slip or slide, an illumination apparatus, which is designed to generate a light sheet, a sensor, and a processor. The two interfaces are formed in that two optical media are applicable in the sample chamber. The light sheet microscope forms a measuring device for acquiring a measured variable. The sensor is designed to acquire the intensities and/or the incidence locations of the two reflection light beams.

Abstract: Disclosed is an interferometric fiber optic sensor for detecting chemical substances. A light source a detector are connected to a light dividing element in an optical path with an optical fiber segment. The optical fiber segment is further optically coupled with a measuring element across a residual cavity. The measuring element further has a face adapted to be exposed to a test substance that may contain a chemical substance to be detected. The optical fiber segment and the measuring element can be held together so that there is only the residual cavity between them. The optical fiber segment is contained, at least along part of its length, within a capillary. A first end part of the capillary is joined with the measuring element while another portion of the capillary is joined or clenched on the optical fiber segment, so that the capillary, the optical fiber segment and the measuring element together form a fiber optic measuring probe as a part of the optical path with the light source and detector.

Abstract: A method, performed by an electronic device, of predicting an electronic structure of a material includes: receiving input data of a user related to elements constituting the first material; applying the received input data to a trained model for estimating a density of state of the first material; and outputting a first graph indicating the density of state for each energy level of the first material output from the trained model, wherein the trained model is trained to generate the first graph based on pre-input data about a plurality of second materials composed of at least some of the elements constituting the first material and a plurality of second graphs representing the density of state for each energy level of the plurality of second materials.

Abstract: A method for true-to-sample measurement by a mobile ingredient analysis system having a housing with a window, an interface for an external reference unit, a display and operating unit, a light source, an optical spectrometer, a camera, an internal reference unit, and an electronic control unit.

Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.

Abstract: Disclosed herein is an electronic apparatus and method capable of identifying a state of an object. The electronic apparatus includes a light-emitting diode array configured to transmit light beams having different wavelengths, a photodiode array configured to receive the light beams, a display, and a processor configured to control the light-emitting diode array to transmit the light beams having the different wavelengths toward an object, identify a state of the object based on intensities reflected on the object according to the light beams having the different wavelengths that are received by the photodiode array, and display information about the state of the object on the display.

Abstract: Methods and devices for the characterization of biological specimens by the use of electroluminescent materials. When placed in close proximity or direct contact to a biological specimen and an electrical signal is transmitted, electroluminescence is generated in response to the presence of the specimen. The electroluminescence produced can be in the form of an image of the specimen. The image is captured by an optical device that collects light and displays or otherwise processes the image according to the particular need or purpose. In general, the method requires preparing an electroluminescent assembly including the biological specimen, a dielectric layer, and a substrate, put together in any order. The method uses an electrical signal transmitted to the assembly. The device may be configured in a closed-circuit electrical configuration or it may be in a configuration where the EL assembly is at open circuit with respect to the power source.

Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.

Abstract: An apparatus for measuring a Raman spectrum may include a processor configured to adjust a Raman probe parameter, set a Raman probe with the Raman probe parameter, obtain a first Raman spectrum of the sample at a first time point and a second Raman spectrum of the sample at a second time point, obtain a difference spectrum between the first Raman spectrum and the second Raman spectrum, determine a degree of similarity between the difference spectrum and an analyte Raman spectrum, determine an optimal Raman probe parameter based on the degree of similarity, and obtain a Raman spectrum of the sample for measuring bio-information by setting the Raman probe with the optimal Raman probe parameter.

Abstract: A system and method include scanning a light detection and ranging (LIDAR) device through a range of orientations corresponding to a scanning zone while emitting light pulses from the LIDAR device. The method also includes receiving returning light pulses corresponding to the light pulses emitted from the LIDAR device and determining initial point cloud data based on time delays between emitting the light pulses and receiving the corresponding returning light pulses and the orientations of the LIDAR device. The initial point cloud data has an initial angular resolution. The method includes identifying, based on the initial point cloud data, a reflective feature in the scanning zone and determining an enhancement region and an enhanced angular resolution for a subsequent scan to provide a higher spatial resolution in at least a portion of subsequent point cloud data from the subsequent scan corresponding to the reflective feature.

Abstract: An optical fiber connection apparatus is disclosed, including a first housing having first receptacle portion receiving and fixating first optical fiber bundle connecting to first optical module on the outside, and a first lens member changing shape or direction of optical signal received from the first optical module and transmitting changed optical signal to the outside or changing shape or direction of optical signal received from the outside and thereby transmitting changed optical signal to the first optical module, and further including a second housing having second receptacle portion receiving and fixating a second optical fiber bundle connecting to a second optical module on the outside, and a second lens member changing shape or direction of optical signal received from the second optical module and thereby transmitting changed optical signal or changing shape or direction of optical signal received from the outside and thereby transmitting changed optical signal to the second optical module.

Abstract: An imaging system for exciting and measuring fluorescence on or in samples comprising fluorescent materials (e.g. fluorescent labels, dyes or pigments). In one embodiment, a device is used to detect fluorescent labels on nucleic acid. In a preferred embodiment, the device is configured such that fluorescent labels in a plurality of different DNA templates are simultaneously detected.

Abstract: A biometric identification system and a method for biometric authentication are described. A biometric authentication system includes at least one light source comprising at least one of a vertical surface emitting laser (VCSEL) or a VCSEL array configured to provide an illumination beam when the biometric authentication system is turned on. The system also includes an optical element configured to broaden the illumination beam and direct the illumination beam towards the portion of the object so as to generate at least one corresponding image response. The system also includes an image sensing unit configured to receive the at least one corresponding image response, capture a speckle pattern in the image response and form at least one of a computer readable image or data representing a speckle contrast in the speckle pattern.

Abstract: Provided are an image processing apparatus, an image processing method, and a moving body that enable removal of noise in distance images. A distance image having a pixel value corresponding to a distance to an object and an intensity image having a pixel value corresponding to the received light intensity of light reflected from the object that are taken at the same angle are acquired, and a pixel value of a pixel in the distance image that corresponds to a pixel having a pixel value smaller than a predetermined threshold in the intensity image is converted into a no-distance pixel. Noise in the distance image is removed in this way.

Abstract: A fabric selection tool provides an automated procedure for recommending and/or selecting a fabric for a window treatment to be installed in a building. The recommendation may be made to optimize the performance of the window treatment in which the fabric may be installed. The recommended fabric may be selected based on performance metrics associated with each fabric in an environment. The fabrics may be ranked based upon the performance metrics of one or more of the fabrics. One or more of the fabrics, and/or their corresponding ranks, may be displayed to a user for selection. The recommended fabrics may be determined based on combinations of fabrics that provide performance metrics for various façades of the building. Using the ranking system provided by the fabric selection tool, the user may obtain a fabric sample and/or order one or more of the recommended fabrics.

Abstract: A method is provided for observing a biological sample between a light source and a pixelated image sensor, the light emitting an incident light beam, which propagates to the sample along a propagation axis and at an emission wavelength, the method including: illuminating the sample with the source; and acquiring an image of the sample with the sensor, no image-forming optic being placed between the sample and the sensor, the sample absorbing some of the beam, such that the acquired image is representative of an absorption of the beam by the sample at the emission wavelength, the source illuminates an area of the sample larger than 1 mm2, the image acquired of the sample by the sensor corresponds to an area of sample larger than 1 mm2, and pixels of the sensor define a detection plane, the sample being placed at a distance from the plane smaller than 1 mm.

Abstract: A device (110) for illuminating a particle comprises: a light waveguide (112; 412a, 412b; 512a, 512b) arranged on a substrate (114); an output coupler (118) configured to output a light beam (150; 450a, 450b; 550a, 550b) forming a sheet-like shape having a cross-section which has an extension in a first direction being larger than a size of a particle; and a fluidic channel (116; 416; 516) arranged on the substrate (114) for guiding a flow of particles along a longitudinal direction of the fluidic channel (116; 416; 516); wherein the sheet-like shape of the light beam (150; 450a, 450b; 550a, 550b) is arranged within the fluidic channel (116; 416; 516) and the first direction of the cross-section of the light beam (150; 450a, 450b; 550a, 550b) forms an angle to the longitudinal direction of the fluidic channel (116; 416; 516).

Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.

Abstract: An apparatus includes a sensor lens defining an axis, a first nozzle and a second nozzle positioned a same perpendicular direction from the axis and spaced along a direction parallel to the axis, and an air source fluidly connected to the nozzles. The nozzles are oriented to emit respective airstreams intersecting the axis and directed apart at an acute angle.

Abstract: Disclosed is a cell analysis method comprising: extracting target cells from a population of cells derived from an epithelial tissue on the basis of N/C ratio representing a relative size of a nucleus to a cytoplasm; classifying the target cells into at least a first group and a second group by difference of amount of DNA; and evaluating a pathology of the epithelial tissue by comparing a ratio of numbers of cells between the first and second groups with a threshold; wherein the threshold varies according to a proportion of the target cells in the population.

Abstract: An apparatus for sensing characteristics of particles in a flow of particles may include a guidance structure configured to guide particles of a stream of particles taken from the flow of particles. The guidance structure defines an inclined surface across which particles of the stream of particles move. The apparatus may further include an image capturing device configured to capture at least one image of particles located on the inclined surface.

Abstract: The technology provides a spectroscopy system having two or more spectrometers with substantially uniform focal lengths. The spectrometers include a detector that converts optical signals into electrical signals to render spectral data. The spectroscopy system includes a computing device that is electrically coupled to one or more detectors to receive the spectral data and compare the spectral data against other spectral data. The other spectral data originates from spectrometers that have substantially similar focal lengths, slit widths, excitation laser wavelengths, or any combination of these. The technology includes an application server that is communicatively coupled to a second spectroscopy system. The application server includes software that enables data sharing among the two or more spectroscopy systems, including sharing the spectral data and the other spectral data. The application server compares sampled spectral data against stored spectral data to identify a match.

Abstract: Embodiments can provide a medical imaging patient bed with an integrated electronic ruler system, comprising a light strip, mounted to the medical imaging bed; a trough comprising an open end and a closed end, mounted to the medical imaging bed and oriented such that the light strip is bounded by the open end and the closed end of the trough; a laser distance meter attached to the open end of the trough; a microcontroller; and a power source configured to provide power to the light strip, laser distance meter, and microcontroller; wherein the microcontroller is configured to illuminate the light strip after one or more distance measurements are received from the laser distance meter when an object is inserted into the trough; wherein a position of the illumination of the light strip corresponds to the one or more distance measurements received from the laser distance meter.

Abstract: Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

Abstract: An OCT system with a swept light source centered around 1.7 ?m for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 ?m swept source laser include higher contrast between lipid and normal tissue and deeper penetration of the optical signals from the 1.7 ?m swept source laser into the tissue. With deeper penetration into the tissue, more structural information from deep within the tissue is obtained. The present invention also features multimodality imaging systems that integrate additional imaging systems into the OCT system at 1.7 ?m. As an example, an integrated 1.3 ?m and 1.7 ?m OCT system is provided which simultaneously generates OCT images using both the OCT systems which are used to characterize and differentiate the types of tissue.

Abstract: Disclosed herein is a novel, compact, real time optical particle identification and characterization system and method of use within both gaseous and liquid media. The system can implement elastic and/or inelastic light scattering techniques simultaneously and complimentarily under the same sensor platform. By separating the sensing components from the electro-optical unit and using optical fibers for interconnection, only the sensing components need to be exposed to the environmental conditions. This reduces the design constraints on the electro-optical unit and permits the incorporation of optical components into the sensor probe that can withstand high-temperature, high-pressure, and corrosive environments. Thus, the system can be used in benign, moderate, and harsh environments.

Abstract: A detecting device for use in multiple-DOF spherical body, which is applied in a camera and a spherical body, and includes: a fasten plate; at least one rotation mechanism; at least one rolling device; and at least one elevation device; and characterized in: the fasten plate has a bottom plate and plural bottom support rods are disposed between the bottom plate and the fasten plate, the bottom plate has a second rotation mechanism having a second fasten plate and a motor output shaft, the fasten plate has a second elevation device at the bottom and a elevation plate at the top and has a second top rotation disk set and a rotation disk input shat, connection guiding rods are disposed between the elevation plate and the second fasten plate, and the second top rotation disk set has a tray and at least one spherical body holding ring.

Abstract: A wavefront detector (100) and method for determining a signal wavefront (Ws) of a signal beam (Ls). A beam combiner (11) is configured to combine the signal beam (Ls) with a reference beam (Lr). An image detector (12) comprising an array of photosensitive pixels (12p) is configured to receive and measure an interference pattern (Wrs) of the combined signal and reference beams (Lr+Ls). A reference light source (14) is configured to generate the reference beam (Lr). A feedback controller (20) is configured to receive an interference signal (IB) based on measurement of at least part of the combined signal and reference beams (Lr+Ls), and control generation of the reference beam (Lr) by a feedback loop based on the interference signal (IB).

Abstract: Disclosed is a method of measuring focus performance of a lithographic apparatus. The method comprises using the lithographic apparatus to print at least one focus metrology pattern on a substrate, the printed focus metrology pattern comprising at least a first periodic array of features, and using inspection radiation to measure asymmetry between opposite portions of a diffraction spectrum for the first periodic array in the printed focus metrology pattern. A measurement of focus performance is derived based at least in part on the asymmetry measured. The first periodic array comprises a repeating arrangement of a space region having no features and a pattern region having at least one first feature comprising sub-features projecting from a main body and at least one second feature; and wherein the first feature and second feature are in sufficient proximity to be effectively detected as a single feature during measurement. A patterning device comprising said first periodic array is also disclosed.

Abstract: Methods and apparatus for measuring a thickness of a coating on an moving object are provided. Light is directed toward the object at a predetermined location on the object such that a portion of the light interacts with the object. A 1D and/or 2D maximum intensities for at least one wavelength channel is captured that is produced by the portion of the light interacting with the object. A measured average intensity of the wavelength channel and/or intensities and their arithmetic derivatives of multi wavelength channel geometries is converted into 1D (averaged) and/or 2D thickness values. Based on these values an acceptability of the coating is evaluated and thickness calculated.

Abstract: Disclosed are methods, systems, and devices for detecting biological analytes in a sample. The disclosed technology can be used to obtain readings of analyte concentration in a sample by imaging scattered light from an angled narrow beam illuminator. A fluid sample containing one or more biological, organic, and inorganic analytes including proteins, viruses, bacteria, phages, toxins, proteins, peptides, DNA, RNA, hormones, chemicals, drugs, and isotopes can be transferred to a microfluidic device having one or more channels with dimensions to generate capillary action for sample transport. The geometry of the microfluidic device may include a reservoir and sensing area, wherein an immunometric reaction can take place for the narrow beam scanning. The test particle may be coated with a specific binding member that is used to bind the binding pair member on an analyte in a sample. Test particles form the binding and the particle/analyte conjugate may be scanned.

Abstract: A system for inspecting a coating on a substrate, the system including a platform that receives a sample including the substrate having the coating, and a light source that directs a plurality of electromagnetic pulses towards a scanning location on the coating, wherein the light source is oriented to direct the plurality of electromagnetic pulses at an oblique angle relative to a surface of the coating. A light detector receives electromagnetic pulses reflected from the sample, wherein a first portion of each electromagnetic pulse is reflected from the surface of the coating, and a second portion of each electromagnetic pulse is reflected from a surface of the substrate. An actuator is coupled to the platform and/or the light source, wherein the actuator moves the platform and the light source relative to each other such that the plurality of electromagnetic pulses are directable towards the scanning location from different rotational positions.

Abstract: Aspects of the disclosure relate to a self-referenced spectrometer for providing simultaneous measurement of a background or reference spectral density and a sample or other spectral density. The self-referenced spectrometer includes an interferometer optically coupled to receive an input beam and to direct the input beam along a first optical path to produce a first interfering beam and a second optical path to produce a second interfering beam, where each interfering beam is produced prior to an output of the interferometer. The spectrometer further includes a detector optically coupled to simultaneously detect a first interference signal produced from the first interfering beam and a second interference signal produced from the second interfering beam, and a processor configured to process the first interference signal and the second interference signal and to utilize the second interference signal as a reference signal in processing the first interference signal.

Abstract: An apparatus includes flow path units 15A to 15K configured to form flow paths 17A to 17K through which a fluid supplied to a target object W is flown; a laser light irradiator 51 configured to irradiate a laser light into the flow path units such that an optical path intersects with a flow direction of the fluid in the flow path units; light receiving elements 45A and 45B provided at the optical path having passed through the flow path units; a detector 6 configured to detect the foreign substance in the fluid based on a signal from the light receiving elements; and a filter unit 57 provided at the optical path between the light receiving elements and the flow path units, and configured to block a Raman scattered light and allow a Rayleigh scattered light to be transmitted to the light receiving elements.