With Viewed Screen Patents (Class 359/369)
  • Patent number: 10539774
    Abstract: Provided is a microscope system including: a plurality of objective lenses that are selectively used to collect fluorescence from a specimen; a detecting unit that obtains image information of the specimen on the basis of the fluorescence collected by the objective lens; and an adjustment unit that adjusts the observation range of the specimen S and that divides the observation range into one or more observation regions corresponding to a capture range captured by the detecting unit, wherein the adjustment unit calculates an observation magnification at which the entire well is included in the observation range, the number of observation regions is minimized, and the resolution becomes the highest, on the basis of information about the size of the well in a multi-plate for accommodating the specimen and information about an objective magnification of the objective lens, and adjusts the observation range on the basis of the calculated observation magnification.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: January 21, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Kanako Kondo, Nobuhiro Takamizawa
  • Patent number: 10060766
    Abstract: An apparatus is disclosed for capturing image information. The apparatus includes a waveguide having opposed planar input and output faces. A diffractive optical element (DOE) is formed across the waveguide. The DOE is configured to couple a portion of the light passing through the waveguide into the waveguide. The light coupled into the waveguide is directed via total internal reflection to an exit location on the waveguide. The apparatus further includes a light sensor having an input positioned adjacent the exit location of the waveguide to capture light exiting therefrom and generate output signals corresponding thereto. A processor determines the angle and position of the coupled light with respect to the input face of the waveguide based on the output signals.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: August 28, 2018
    Assignee: MAGIC LEAP, INC.
    Inventor: Adrian Kaehler
  • Publication number: 20140240823
    Abstract: A wide-field optical microscope and method capable of resolving images down to 0.1 ? with a magnification range in excess of 250 million power includes an objective having a primary and a secondary element. A sample is held so that the area of interest is at a location that is closer to the primary element than the focal length of the primary element. The primary element collects and collimates light reflected from the sample. The secondary element then focuses the collimated light onto a pinhole aperture, which blocks all light rays that were not parallel, thus producing a non-focused reflected pattern. The non-focused reflected pattern passes through a field stop and is then magnified by one or more negative optical elements and additional field stops to produce an enlarged pattern.
    Type: Application
    Filed: November 27, 2013
    Publication date: August 28, 2014
    Applicant: Yancy Corporation
    Inventors: Jeffrey Porter, Cheryl Watkins
  • Patent number: 8786946
    Abstract: The surgical microscope system includes a first binocular microscope and a first display device. The first binocular microscope includes an objective lens, a first right ocular lens which provides a first image based on a light flux transmitted through the objective lens, and a first left ocular lens which provides a second image based on a light flux transmitted through the objective lens. The first display device can be disposed opposite to or in alignment with the first binocular microscope, and includes a first right-eye image display surface for displaying the first image and a first left-eye image display surface for displaying the second image. The first display device can be reversed about a horizontal axis extending in a direction along which the first right-eye image display surface and the first left-eye image display surface are located in alignment.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: July 22, 2014
    Assignee: Mitaka Kohki Co., Ltd.
    Inventor: Katsushige Nakamura
  • Patent number: 8654223
    Abstract: The image pickup apparatus includes an image sensor unit including an optical system forming an optical image of an object placed on a stage part and plural image sensors each of which captures part of the optical image, a drive mechanism relatively moving the stage part and the image sensor unit, and a processing part causing the image sensor unit to perform plural image capturing operations with causing the drive mechanism to relatively move the stage part and the image sensor unit after each image capturing operation, and combining the plural captured images to produce a whole image covering the whole image capturing area. The plural image sensors are arranged such that an effective diameter of the optical system necessary to introduce light from the stage part to all the plural image sensors is smaller than a diameter of a circle circumscribed to the whole image capturing area.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: February 18, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventor: Tomoaki Kawakami
  • Patent number: 8514685
    Abstract: Optical devices based on internal conical refraction for developing new set-ups, methods and applications based on the specific properties of internal conical diffraction. The devices include several set-ups, methods and applications consisting of biaxial crystal(s)—one or more polarization elements and optical elements. The biaxial crystal is an optical crystal which may belong to the trigonal, orthorhombic or trigonal crystal classes.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: August 20, 2013
    Assignee: BioAxial SAS
    Inventor: Gabriel Y. Sirat
  • Patent number: 8345351
    Abstract: A microscope system which can improve the ease of use and the observation environment when a sample is observed using a microscope formed of a stand and a main body which is removable from the stand. A microscope is formed of a main body and a stand, and the main body is removable from the stand. The main body includes an objective lens, an image optical system, a CCD, a compact monitor and a battery, so that the main body, when removed from the stand, can function independently as a microscope. If the main body is mechanically connected to the stand, the main body and the stand are electrically connected via connectors, and an observation image captured by the CCD is supplied from the main body to the stand via the connectors, and is displayed on a monitor.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: January 1, 2013
    Assignee: Nikon Corporation
    Inventor: Atsushi Takeuchi
  • Patent number: 8300669
    Abstract: A control system and apparatus for use with an ultra-fast laser is provided. In another aspect of the present invention, the apparatus includes a laser, pulse shaper, detection device and control system. A multiphoton intrapulse interference method is used to characterize the spectral phase of laser pulses and to compensate any distortions in an additional aspect of the present invention. In another aspect of the present invention, a system employs multiphoton intrapulse interference phase scan. Furthermore, another aspect of the present invention locates a pulse shaper and/or MIIPS unit between a laser oscillator and an output of a laser amplifier.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 30, 2012
    Assignee: Board of Trustees of Michigan State University
    Inventors: Marcos Dantus, Igor Pastirk, Vadim Lozovoy, Matthew Comstock
  • Patent number: 8275226
    Abstract: A multi-mode optical fiber delivers light from a radiation source to a multi-focal confocal microscope with reasonable efficiency. A core diameter of the multi-mode fiber is selected such that an etendue of light emitted from the fiber is not substantially greater than a total etendue of light passing through a plurality of pinholes in a pinhole array of the multi-focal confocal microscope. The core diameter may be selected taking into account a specific optical geometry of the multi-focal confocal microscope, including pinhole diameter and focal lengths of relevant optical elements. For coherent radiation sources, phase randomization may be included. A multi-mode fiber enables the use of a variety of radiation sources and wavelengths in a multi-focal confocal microscope, since the coupling of the radiation source to the multi-mode fiber is less sensitive to mechanical and temperature influences than coupling the radiation source to a single mode fiber.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: September 25, 2012
    Assignee: Spectral Applied Research Ltd.
    Inventor: Richard Berman
  • Patent number: 8212865
    Abstract: This is a microscope image pickup apparatus for shooting and forming the observation images of a specimen in order to observe it by a microscope. The microscope image pickup apparatus comprises an image pickup unit for shooting and forming the observation images, a display unit for dynamically displaying the observation images shot and formed by the image pickup unit in succession and an operating state detection unit for detecting an operating state of a microscope operation part in order to operate the microscope on the basis of the change of the observation images dynamically displayed on the display unit. The present invention provides a microscope image pickup apparatus, a microscope image pickup program product, a microscope image pickup program transmission medium and a microscope image pickup method which are capable of displaying an optimum moving image according to the operating state of the microscope.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: July 3, 2012
    Assignee: Olympus Corporation
    Inventor: Kouji Fujiyoshi
  • Patent number: 8164829
    Abstract: A system for acquiring and displaying images of preparations is provided. The system includes a first and second illumination device, each including an illumination source defining a respective illumination beam path amid configured to emit light to illuminate the preparation. A camera and a display for displaying a portion of the preparation are further provided. The preparation can be placed on a stage that is movable in x and y coordinate directions. The frame is also provided with a combining device configured to combine the first imaging beam path and the second imaging beam path, and direct them to the camera.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: April 24, 2012
    Assignee: Leica Microsystems CMS GmbH
    Inventor: Michael Ganser
  • Patent number: 8159744
    Abstract: To provide a laser scanning apparatus and a laser scanning microscope capable of securely conducting a condition setting at the time of laser scanning while suppressing a damage on a plane to be irradiated. Accordingly, a laser scanning apparatus includes a light deflecting unit disposed in a light path of laser light directed toward a plane to be scanned, user interfaces through which operational contents of the light deflecting unit are designated by a user, generating units generating driving signals of the light deflecting unit in accordance with the designated operational contents, and testing units test-driving the light deflecting unit with the driving signals while keeping the laser light off and measuring the operational contents of the light deflecting unit during the driving.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: April 17, 2012
    Assignee: Nikon Corporation
    Inventor: Atsushi Tsurumune
  • Publication number: 20110286090
    Abstract: There is provided a method for analyzing at least one object under a first microscope and a second microscope concurrently by linking the two microscopes together. Movement of one microscope will result in movement of the other. This is done by computing a transformation to link a first coordinate system and a second coordinate system and generating guidance data when one of the two microscopes is displaced, the guidance data corresponding to a set of operations to be applied to the other microscope to follow movement of the microscope that is displaced.
    Type: Application
    Filed: May 2, 2011
    Publication date: November 24, 2011
    Applicant: FORENSIC TECHNOLOGY WAI INC.
    Inventors: Alain BEAUCHAMP, Danny ROBERGE, Benoît PERRON
  • Patent number: 8009353
    Abstract: A comparison optical system (1) comprising several image-acquiring optical subsystems is disclosed. A bridge (3) mechanically and optically connects the optical subsystems to one another. Each of the image-acquiring optical subsystems possesses an XYZ stage (8a, 8b), movable in motorized fashion, on which a sample to be examined is placed. Also provided is a control unit which moves the XYZ stages (8a, 8b), movable in motorized fashion, synchronously in all three spatial directions. The synchronous motion of the XYZ stages (8a, 8b) can be switched on and off by the user.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: August 30, 2011
    Assignee: Leica Microsystems CMS GmbH
    Inventor: Manfred Gilbert
  • Patent number: 7969651
    Abstract: An educational stereo microscopic image display apparatus includes a bag-shaped main box, a planar screen panel which is provided at a front portion of the main box and has a size of 20 inches to 40 inches, and a microscopic image optical system which is provided at a rear portion of the main box and has an objective lens and an image conversion device which converts an optical signal into an electric signal. An image of an object to be inspected is magnified by the microscopic image optical system, and the magnified image is displayed on the large-scale planar screen panel. Accordingly, a teacher and a large number of students (up to about one hundred) can conveniently observe the image of the object to be inspected at the same time.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: June 28, 2011
    Inventor: Hae-Yong Choi
  • Patent number: 7864413
    Abstract: An examination apparatus that observes a specimen in a stationary state while suppressing the blurring caused by a control delay. The apparatus includes a first optical system and a second optical system for imaging light produced in a specimen, a first image-acquisition unit with a plurality of first image-acquisition devices for detecting an image formed by the first optical system, a second image-acquisition unit with a second image-acquisition device for acquiring an image formed by the second optical system, and a driving unit that causes the images to be formed at the same position in the second image-acquisition unit. The value obtained by dividing the pixel size Y of the first image-acquisition devices by the magnification X of the first optical system is smaller than the value obtained by dividing the pixel size Y? of the second image-acquisition device by the magnification X? of the second optical system.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: January 4, 2011
    Assignee: Olympus Corporation
    Inventors: Yoshihisa Tanikawa, Tomoaki Sato, Ikuko Sakai
  • Patent number: 7864414
    Abstract: Providing a microscope capable of movably adjusting an observation field of a sample without moving the sample. The microscope includes a first objective lens, a second objective lens, a mirror, an angular adjustment mechanism, and a shift mechanism. The first objective lens is disposed to the sample side. The second objective lens forms an intermediate image of the sample together with the first objective lens. The mirror is disposed with a tilt on an optical path between the first objective lens and the second objective lens. The angular adjustment mechanism rotatably adjust the mirror in the tilt direction. The shift mechanism makes a shift adjustment of the second objective lens in an axial direction of a rotation axis of the mirror. With the configuration, the observation field can be moved two-dimensionally by the angular adjustment mechanism.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: January 4, 2011
    Assignee: Nikon Corporation
    Inventors: Ichiro Sase, Shuji Toyoda
  • Publication number: 20100118393
    Abstract: An electronic device for biological microscopy includes a display unit and a main body adapted to the display unit, wherein an auto-focus microscope, an inspection area, and a computer are housed within the main body. The inspection area includes a first side and a second side opposite to the first side. The microscope includes an object lens, an eye lens, and an extension lens configured between the object lens and the eye lens. The object lens is configured at the first side of the inspection area, and a lighting component is configured at the second side of the inspection area. A thermostat apparatus is configured on the inspection area. A camera electrically connected to the computer is configured on the eye lens and transmits the captured image to the computer for analysis with a pre-installed software.
    Type: Application
    Filed: February 10, 2009
    Publication date: May 13, 2010
    Inventor: Kuang-Yuan Lin
  • Publication number: 20100091362
    Abstract: A complex type microscopic device includes a slider unit moving a stage, an optical microscope, a scanning electron microscope with an electron axis intersecting with an optical axis of the optical microscope, an optical measurement/observation unit having a magnification between those of the scanning electron microscope and the optical microscope and co-using an objective lens with the optical microscope, and a control unit controlling the entire device, and a display unit having a display screen. During display of a low-magnification optical microscopic image, the control unit controls the display unit to display, on the image, a representation to designate an area to be observed at a magnification of the optical measurement/observation unit, and to display, on the image, another representation to designate an area to be observed at a magnification of the scanning electron microscope during display of a high-magnification optical microscopic image.
    Type: Application
    Filed: October 14, 2009
    Publication date: April 15, 2010
    Inventors: Hisashi Isozaki, Fumio Ohtomo, Kazuo Nunokawa
  • Patent number: 7649681
    Abstract: A surgical microscope (1) includes a viewing unit (3) for viewing an object (5) and an image projection module (7) for inputting image data (9) into the viewing unit (3). The image projection module (7, 107, 207, 307) includes a plano-convex lens and a plano-concave lens. The image projection module (7, 107, 207, 307) includes an image display unit (11, 111, 211, 311).
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: January 19, 2010
    Assignee: Carl-Zeiss-Stiftung
    Inventors: Christoph Hauger, Ulrich Gold, Christian Lücke, Margit Krause-Bonte, Dirk L. Brunner, Martin Pelzer
  • Patent number: 7633676
    Abstract: In a microscope comprising an objective and an eyepiece, which displays images of an object sensed by the objective, as well as comprising a camera which records the images of the object sensed by the objective, an eyepiece is provided which senses an image generated by a display, said display displaying the image recorded by the camera.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: December 15, 2009
    Assignee: Carl Zeiss Jena GmbH
    Inventors: Robert Brunner, Michael Haisch, Ulrich Naegele
  • Patent number: 7589839
    Abstract: A microscope examination apparatus is provided that includes a light source for emitting excitation light or illumination light to a specimen placed on a stage; an objective lens opposing the stage and capable of focusing fluorescence or reflected light from the specimen; an image-forming lens for forming an image of the specimen obtained by the objective lens; and an image-capturing unit for capturing the image of the specimen forming by the image-forming lens, wherein a plurality of the objective lenses having different magnifying powers is provided, and an objective-lens switching mechanism for switching among the objective lenses is provided, and wherein a plurality of the image-forming lenses having different magnifying powers is provided, and an image-forming-lens switching mechanism for switching among the image-forming lenses is provided.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: September 15, 2009
    Assignee: Olympus Corporation
    Inventors: Yoshihiro Kawano, Keiji Shimizu, Minoru Sukekawa, Tsuyoshi Mochizuki, Susumu Honda, Kazuhiro Hayashi
  • Patent number: 7586688
    Abstract: The invention relates to a microscope having an optics system which represents an object on an image sensor and a screen that shows the image data provided by the image sensor and which is the only output medium for visually observing the object, wherein the representation capability of the optics system and the resolution (A) of the image sensor complies with the following correlation: F×N/M=0.5 A, wherein F indicates a factor, N indicates the numerical aperture of the optics systems, M is the magnification factor and A indicates the resolution of the image sensor in pixels per millimeter.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: September 8, 2009
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Holger Wiederhöft, Helmut Meissner
  • Publication number: 20090116101
    Abstract: A light-tight enclosure system for housing an automated microscope.
    Type: Application
    Filed: December 8, 2008
    Publication date: May 7, 2009
    Applicant: Ikonisys, Inc.
    Inventors: Triantafyllos Tafas, Yash Agarwal, Youngmin Kim, Wei Guo, Richard Eberle, Joseph Turgeon, Michael Kilpatrick, Petros Tsipouras
  • Patent number: 7486886
    Abstract: A photo-micrographing device includes a microscope, a unit for obtaining an image of an inspection object, a unit for setting a plurality of view fields of the microscope and storing position information of a stage corresponding to each view field, a unit for storing setting information of the microscope and a camera unit in each view field, a unit for storing shooting conditions corresponding to each view field where time-lapse shooting is applied, a unit for obtaining a time-lapse shooting image for each view field where the time-lapse shooting is applied, based on the stored position information, the stored setting information and the stored shooting conditions, and a unit for collectively displaying latest taken time-lapse shooting images for each view field where the time-lapse shooting is applied.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: February 3, 2009
    Assignee: Olympus Corporation
    Inventors: Hideaki Endo, Akitsugu Kagayama, Katsuyoshi Yamaguchi
  • Patent number: 7480093
    Abstract: A surgical microscope system (1, 2, 3, 4, 5, 6) having a display (7a-7e). Data essential for the surgical procedure, for example video images, are displayed in the observer's immediate field of view, thus making it unnecessary to turn one's head away from the surgical visual field. Because of its optical properties, the display (7a-7e) can also be attached, for example, on the curved exterior of the microscope body (2) or also on an X-Y coupling (6) that may be present. An rigid OLED display or a flexible OLED display is preferably used.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: January 20, 2009
    Assignee: Leica Microsystems (Schweiz) AG
    Inventor: Ulrich Sander
  • Publication number: 20090015911
    Abstract: A motor-operated microscope system has a motor-operated microscope section including an illumination optical system, an electric stage, an image forming optical system having an objective lens and an image forming lens, and an image pickup device; a housing; a control device having a screen display and an arithmetic processing section; and software displaying an operating condition setting screen of the motor-operated microscope section on the screen display and controlling an operation of the motor-operated microscope section in accordance with a set condition.
    Type: Application
    Filed: June 18, 2008
    Publication date: January 15, 2009
    Inventors: Yuichiro Matsuo, Kosuke Takagi
  • Patent number: 7454103
    Abstract: Lightwave diffraction device formed of a dielectric layer (4), a mirror (12) arranged at the lower face (10) of said layer, a semi-reflective structure (13) arranged at the upper face (100) of said layer, and a diffractive structure (8) arranged in said layer or on its faces. The height (H) of the layer is chosen so as to substantially satisfy the resonance condition for at least one leaky mode propagating in said layer for at least one given incident wave having a determined wavelength? and a determined incidence angle ?c. Next, the diffractive structure is arranged so that there is no propagating positive diffracted order, and so that all negative orders other than the ?1st propagating order have zero or a relatively small diffraction efficiency, the reflected ?1st order propagating in a direction non-parallel to the incident wave. This diffraction device allows a high diffraction efficiency of up to 100% for the ?1st order.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: November 18, 2008
    Inventor: Olivier M. Parriaux
  • Publication number: 20080180794
    Abstract: A light-tight enclosure system for housing an automated microscope.
    Type: Application
    Filed: August 2, 2007
    Publication date: July 31, 2008
    Applicant: Ikonisys, Inc.
    Inventors: Triantafyllos Tafas, Yash Agarwal, Youngmin Kim, Wei Guo, Richard Eberle, Joseph Turgeon, Michael Kilpatrick, Petros Tsipouras
  • Publication number: 20080130103
    Abstract: A clear image having suppressed blurring due to pulsing is obtained by in-vivo examination of biological tissue or various internal organs of mammals, including small laboratory animals.
    Type: Application
    Filed: June 9, 2005
    Publication date: June 5, 2008
    Applicant: Olympus Corporation
    Inventors: Mitsuhiro Hara, Hiroshi Tosaka, Akihiro Horii, Yoshihisa Tanikawa
  • Publication number: 20080088917
    Abstract: An educational stereo microscopic image display apparatus is disclosed. The apparatus includes a bag-shaped main box, a planar screen panel which is provided at a front portion of the main box and has a size of 20 inches to 40 inches, and a microscopic image optical system which is provided at a rear portion of the main box and has an objective lens and an image conversion device which converts an optical signal into an electric signal. An image of an object to be inspected is magnified by the microscopic image optical system, and the magnified image is displayed on the large-scale planar screen panel. Accordingly, a teacher and a large number of students (up to about one hundred) can conveniently observe the image of the object to be inspected at the same time.
    Type: Application
    Filed: May 14, 2007
    Publication date: April 17, 2008
    Inventor: Hae-Yong Choi
  • Patent number: 7149332
    Abstract: A method of and apparatus for viewing microscopic images include transmitting tiled microscopic images from a server to a client. The client assembles the tiled images into a seamless virtual slide or specimen image and provides tools for manipulating image magnification and viewpoint. The method and apparatus also provides a virtual multi-headed microscope function which allows scattered viewers to simultaneously view and interact with a coherent magnified microscopic image.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: December 12, 2006
    Assignee: Bacus Laboratories, Inc.
    Inventors: James W. Bacus, James V. Bacus
  • Patent number: 7106502
    Abstract: A Microscope Imaging System (CMIS) with intelligent controls is disclosed that provides techniques for scanning, identifying, detecting and tracking microscopic changes in selected characteristics or features of various surfaces including, but not limited to, cells, spheres, and manufactured products subject to difficult-to-see imperfections. The practice of the present invention provides applications that include colloidal hard spheres experiments, biological cell detection for patch clamping, cell movement and tracking, as well as defect identification in products, such as semiconductor devices, where surface damage can be significant, but difficult to detect. The CMIS system is a machine vision system, which combines intelligent image processing with remote control capabilities and provides the ability to auto-focus on a microscope sample, automatically scan an image, and perform machine vision analysis on multiple samples simultaneously.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: September 12, 2006
    Assignee: The United States of America as represented by the Administrator of National Aeronautics and Space Administration
    Inventor: Mark McDowell
  • Patent number: 7050225
    Abstract: A first image-forming optical system that receives a beam of light from an objective forms a first image forming point. The first image-forming optical system forms the beam of light into a first optical image at the first image-forming point and relays the first optical image. A second image-forming optical system is provided to form an image of a monitor near the first image-forming point, and the image is relayed by the first image-forming optical system. A third image-forming optical system is arranged in the first image-forming optical system to form a second image-forming point. The third image-forming optical system forms a second optical images at the second image-forming point and guide the optical image to an eyepiece lens.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: May 23, 2006
    Assignee: Olympus Corporation
    Inventor: Motokazu Nakamura
  • Patent number: 7042639
    Abstract: A Microscope Imaging System (CMIS) with intelligent controls is disclosed that provides techniques for scanning, identifying, detecting and tracking microscopic changes in selected characteristics or features of various surfaces including, but not limited to, cells, spheres, and manufactured products subject to difficult-to-see imperfections. The practice of the present invention provides applications that include colloidal hard spheres experiments, biological cell detection for patch clamping, cell movement and tracking, as well as defect identification in products, such as semiconductor devices, where surface damage can be significant, but difficult to detect. The CMIS system is a machine vision system, which combines intelligent image processing with remote control capabilities and provides the ability to auto-focus on a microscope sample, automatically scan an image, and perform machine vision analysis on multiple samples simultaneously.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: May 9, 2006
    Assignee: The United States of America as represented by the Administrator of NASA
    Inventor: Mark McDowell
  • Patent number: 7011970
    Abstract: This new automatic bio-manipulation factory system for manipulating a single cell comprises: a bio-MEMS that transports, separates, and extracts a single cell for manipulation from a plurality of cells, controls the rotation-orientation of the extracted cell automatically, and enables the extracted cell to maintain a certain temperature; and a micro manipulation system that obtains vision information and manipulation information about the extracted single cell and the manipulation tool, provides such information to operator, manipulates the extracted single cell by transmitting the rotation-orientation feedback information and the cell manipulation order of the operator to the bio-MEMS, and manipulates the manipulation tool by transmitting the tool manipulation order of the operator to the manipulation tool. The conventional manual and individualized single cell manipulation can be automated and processed collectively by systematically combining the bio-MEMS with the micro manipulation system.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: March 14, 2006
    Assignee: Korean Institution of Science and Technology
    Inventors: Byung-Kyu Kim, Jung-Yul Park, Deok-Ho Kim, Jong-Oh Park
  • Patent number: 6937638
    Abstract: The present invention relates to the tailoring the reflectivity spectrum of a SGDBR by applying digital sampling theory to choose the way each reflector is sampled. The resulting mirror covers a larger wavelength span and has peaks with a larger, more uniform, coupling constant (?) than the mirrors produced using conventional approaches. The improved mirror also retains the benefits of the sample grating approach. Additionally, most of the embodiments are relatively simple to manufacture.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: August 30, 2005
    Assignee: Agility Communications, Inc.
    Inventors: Gregory A. Fish, Larry A. Coldren
  • Patent number: 6903869
    Abstract: An illumination system for microscopy includes a light source, a first spectral element dispersing light from the light source, a reflecting member selectively reflecting light dispersed by the first spectral element, a second spectral element combining light reflected by the reflecting member, a dichroic mirror, an objective lens, and an image sensor. The first spectral element is placed at the front focal point of a first lens, the reflecting member is placed at a position where the back focal point of the first lens coincides with the front focal point of a second lens, and the second spectral element is placed at the back focal point of the second lens.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: June 7, 2005
    Assignee: Olympus Corporation
    Inventors: Takashi Fukano, Atsushi Miyawaki, Keiji Shimizu, Yoshihiro Kawano
  • Patent number: 6875983
    Abstract: An object of the present invention is to provide an electron microscope that is capable of improving work efficiency when restarting sample observation. A control unit for controlling observation-condition setting devices, which include an electron-gun control unit, an irradiation-lens control unit, an objective-lens control unit, a magnifying-lens-system control unit, and a sample-stage control unit, is provided. When image data of a certain sample is specified, observation condition data of the sample is retrieved. Then, observation conditions, which are the same as those used when the image data of the sample has been saved, are automatically restored on an electron microscope on the basis of the observation condition data. As a result, an image, which is the same as the stored image, is restored faithfully.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: April 5, 2005
    Assignees: Hitachi, Ltd., Hitachi Science Systems, Ltd.
    Inventors: Eiko Nakazawa, Isao Nagaoki
  • Patent number: 6798570
    Abstract: A light microscope illuminator with a light source off the conjugate objective aperture allowing light beam shaping and modifying devices to be located at the conjugate objective aperture.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: September 28, 2004
    Inventor: Gary Greenberg
  • Patent number: 6791756
    Abstract: A multilevel optical phase element is illuminated with a light source having a plurality of wavelengths of interest. The multilevel phase element disperses light from the light source by diffraction and focuses the dispersed light onto an imaging plane. A light modulating display in the imaging plane having a plurality of pixel elements is actuated. Each pixel element is assigned to transmit a predetermined spectral region within the near field region of the multilevel display element so as to receive the dispersed and focused light from the multilevel optical phase element. A system for displaying a color image includes a light source emitting a plurality of wavelengths of interest, a multilevel optical phase element, and a light modulating electronic display.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 14, 2004
    Assignee: Massachusetts Institute of Technology
    Inventor: Gary J. Swanson
  • Patent number: 6741391
    Abstract: There is provided a three-dimensional object observing microscope which can easily observe a three-dimensional object in a three-dimensional manner. A three-dimensional object observing microscope comprising a table on which a three-dimensional object is placed, an imaging part which consists of an imaging lens and an imaging camera for imaging this three-dimensional object from an inclined upper position, and a casing which supports the imaging part rotatably in a horizontal direction and also integrally supports the table and the imaging part.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: May 25, 2004
    Assignee: Sony Corporation
    Inventors: Eiji Ishihara, Shinsuke Hiraoka, Yuji Ikegami, Takashi Mizusawa, Tozaburo Nishimura
  • Patent number: 6738190
    Abstract: A method for examining a specimen (11) by means of a confocal scanning microscope having at least one light source (1), preferably a laser, to generate an illuminating light beam (4) for the specimen (11), and a beam deflection device (9) to guide the illuminating light beam (4) over the specimen (11) comprises the following method steps: Firstly a preview image is acquired. Then at least one region of interest in the preview image is marked. This is followed by allocation of individual illuminating light beam wavelengths and/or illuminating light beam power levels to the region or regions. Illumination of the region or regions of the specimen (11) in accordance with the allocation is then accomplished. Lastly, the reflected and/or fluorescent light proceeding from the specimen (11) is detected.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: May 18, 2004
    Assignee: Leica Microsystems Heidelberg GmbH
    Inventors: Johann Engelhardt, Juergen Hoffmann, Werner Knebel
  • Publication number: 20040051941
    Abstract: Laser-scanning microscope with at least one detection radiation input, in which an aperture plate is installed in front of the detector, whereby optics with variable transmission lengths and a fixed focal distance is provided for focusing varying wavelengths of the detected light onto the aperture plate level at the detection radiation path, which realizes the imaging from the infinite space into an image level with a finite conjugate distance,
    Type: Application
    Filed: March 28, 2003
    Publication date: March 18, 2004
    Inventors: Johannes Winterot, Michael Goelles
  • Publication number: 20040008271
    Abstract: An imaging device has a zoom lens system having a plurality of lens units and forming an optical image of an object so as to continuously optically zoom by varying distances between the lens unit; and an image sensor converting the optical image formed by the zoom lens system to an electric signal. The zoom lens system has from an object side, a first lens unit being overall negative and including a reflecting surface that bends a luminous flux substantially 90 degrees; and a second lens unit disposed with a variable air distance from the first lens unit, and having an optical power, and wherein at least one lens element made of resin is included in the entire lens system.
    Type: Application
    Filed: July 1, 2003
    Publication date: January 15, 2004
    Applicant: MINOLTA CO., LTD.
    Inventors: Hitoshi Hagimori, Yasushi Yamamoto, Genta Yagyu, Kazuhiko Ishimaru
  • Patent number: 6678090
    Abstract: A microscope is disclosed for observing a magnified area. Fade-in means (32a) arranged in the path (1) of the rays of the microscope (82) reflect a thin focused beam of light (101) into the path (1) of rays. The beam of light (101) is deflected or modulated by deflecting means (102) to supply an image that can be recognised by an observer (100). The image may be projected onto the object (22) either directly or indirectly, for example through a diffusing screen (108a).
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: January 13, 2004
    Assignee: Leica Microsystems AG
    Inventor: Roger Spink
  • Patent number: 6628457
    Abstract: Angular speed sensors and acceleration sensors are built into the casing of a video-type stereoscopic microscope. The angle of rotation of the stereoscopic microscope detected by the angular speed sensors and the amount of shift of the stereoscopic microscope detected by the acceleration sensors are input to a microscope control unit. This microscope control unit controls a vibration compensator based on the result of the detection. The vibration compensator shifts a lens within a plane orthogonal to its the optical axis so that object light from a field is deflected to a direction parallel to the optical axes of individual zoom optical systems. The vertical width AV of the field and the working distance L of this video microscope satisfy the following inequality: 1/AV>1/(11.46+0.011×L).
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: September 30, 2003
    Assignee: Asahi Kogaku Kogyo Kabushiki Kaisha
    Inventor: Eiichi Ito
  • Publication number: 20030161038
    Abstract: The invention relates to a microscope and a method for measuring the surface topography of a workpiece in a quantitative and optical manner. The invention includes a differential interference contrast microscope embodiment according to Nomarski, comprising a light source, a polariser, a changeable Nomarski prism and an analyser. The light source has a narrow frequency spectrum and/or is provided with a special filter having a narrow frequency spectrum; and the microscope is provided with a phase displacement interferometry evaluation unit.
    Type: Application
    Filed: February 19, 2003
    Publication date: August 28, 2003
    Inventors: Helmut Tobben, Dirk-Roger Schmitt, Gabriele Ringel
  • Patent number: 6597507
    Abstract: An external resonator type wavelength variable light source comprises a semiconductor laser 5 formed on one end face with a antireflection coating 5a, a lens 6 for converting emitted light from the end face of the semiconductor laser 5 formed with the antireflection coating 5a into collimated light, a diffraction grating 7 for selecting a wavelength of the collimated light provided through the lens 6 and diffracting the light, and a mirror for reflecting the light diffracted through the diffraction grating 7 and feeding back the light again diffracted through the diffraction grating 7 into the semiconductor laser 5 through the lens 6. A V-groove grating mirror 8 having reflecting faces with an arrangement like a grating, of a plurality of V grooves 2 each shaped like V at right angles in cross section in a base material 1 with a reflection coating 3 formed on the surface of each V groove is used as the mirror.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: July 22, 2003
    Assignee: Ando Electric Co., Ltd.
    Inventor: Keisuke Asami
  • Patent number: 6580554
    Abstract: A method and an arrangement for beam control in a scanning microscope are disclosed. The scanning microscope comprises means for acquiring and displaying (3) a preview image (7) and a microscope optical system (51). Means for marking (5) at least one region of interest (27, 29) in the preview image (7) are provided. A first beam deflection device (43, 67, 68) displaces the scan field (31, 33) onto the region of interest (27, 29); and a second beam deflection device (49, 72, 94) serves for meander-shaped scanning within the scan field (31, 33).
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: June 17, 2003
    Assignee: Leica Microsystems Heidelberg GmbH
    Inventors: Johann Engelhardt, Werner Knebel