Abstract: The present invention relates to compositions and methods for manufacturing an adjuvant comprising a saponin using a microfluidic device and to aspects thereof.

Abstract: The present disclosure provides devices, systems, methods for processing and/or analyzing a biological sample. An analytic device for processing and/or analyzing a biological sample may comprise a moving carriage. The analytic device may be portable. The analytic device may receive instructions for performing an assay from a mobile electronic device external to a housing of the analytic device.

Abstract: A static mixer 10 for mixing a fluid flow having at least two components is disclosed, as well as a method for mixing first and second components with the static mixer 10. The static mixer 10 includes a mixing conduit 20 having a first inner surface 38a, a second inner surface 38b that extends from the first inner surface 38a, and a third inner surface 38c that extends from the first inner surface 38a to the second inner surface 38b. The first, second, and third inner surfaces 38a, 38b, 38c define a mixing passage receiving the fluid flow. The first and second inner surfaces 38a, 38b are offset by a first acute angle, the first and third surfaces 38a, 38c are offset by a second acute angle, and the second and third surfaces 38b, 38c are offset by a third acute angle. The static mixer 10 includes a mixing element 100 positioned in the mixing passage.

Abstract: A disposable, bio-degradable food and beverage storage container, preferably of cardboard construction. The storage container is comprised of a cylindrical body portion and a removable lid having a seal that is also comprised of a biodegradable material. The interior surface of the body portion of the storage container is further comprised of an embossed portion line and a portion indicator. In one embodiment of the storage container, the body portion comprises a pair of opposing and spaced apart mixers fixedly attached to the interior surface for the mixing and/or agitation of the contents of the storage device in a spill-proof manner.

Abstract: A planar flow reactor includes a straight planar process channel, a flow generator, and a plurality of static mixing elements disposed within the process channel. The flow generator is configured to generate a pulsatile flow within the process channel, and the static mixing elements are configured to locally split and recombine the flow. The straight planar process channel enables the generation of a flow pattern that is largely independent of the width of the process channel, meaning that the throughput may be increased by increasing the width without significantly affecting the residence time distribution or the flow behavior. Furthermore, by creating a pulsatile flow within the process channel, turbulence and/or chaotic fluid flows may be generated even at low net flow rates, i.e. low net Reynolds numbers.

Abstract: The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

Abstract: Embodiments of the present invention may provide fluid flow coordinators, passive flow field modifiers, or even inwardly protruding helical spines which can be used in continuous, scalable, low energy usage, bioreactor systems perhaps to provide optimal mixing of microorganisms with nutrients, gases, or the like or even to move microorganisms, such as algae, in and out of light for effective and optimal growth.

Abstract: A point of care testing assay system for determining the presence and/or amount of an analyte of interest in a sample, and methods for using such assay system, are disclosed. The system comprises a microfiuidic means capable of performing testing with low sample volume in a sample matrix, and having high sensitivity and substantially a 5-log wide dynamic range and capable of performing an assay in approximately fifteen minutes, and in which the microfiuidic means comprises a microfiuidic testing cartridge with associated electronics, a precision pipettor, a high sensitivity detection module, a motion stage, and an on-board electronics display means that can be read by a user as an indication of the presence and/or amount of the analyte in the sample.

Abstract: A fluid flow structure for a washing machine is located within a wash tank of the washing machine, which includes a fluid flow guide surface, and a support for the guide surface. The guide surface includes at least one region contoured inconsistently from the contour of at least one corresponding wall of the washing machine wash tank. The contour of the guide surface is generally curved so as to aide in reducing and/or preventing the pinning of items that often occurs in rectangular wash tanks of the prior art. The support for the guide surface creates a gap between the guide surface and at least one wall of the washing machine wash tank.

Abstract: A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.

Abstract: A biodegradable and dissolvable container may include a biodegradable and water soluble shell defining the container sized to accommodate a volume of a liquid, the shell having walls extending upward from a closed bottom; an exterior water insoluble layer coating an exterior surface of the walls of the shell; and an inner water insoluble layer coating an interior of the shell, wherein the container may completely dissolve in water over a predetermined period of time.

Abstract: There is presented a microfluidic device comprising a plurality of layers and a common manifold, wherein a fluid comprising a target population of particles having a specified range of diameters may be processed by the device by flowing from the common manifold through the channels of each layer within the plurality of layers, and fluid collected from a first outlet of each layer within the plurality of layers comprises the target population of particles, and fluid collected from a second outlet of each layer within the plurality of layers is substantially devoid of the target population of particles. A method of use of said device and systems comprising at least one said device are also presented.

Abstract: An apparatus for treating a flowable food product includes a container constructed from a first plastic material; an injection chamber arranged within the container, and including an inlet and an outlet in fluid communication with the injection chamber; at least one nozzle constructed from a second plastic material, the at least one nozzle including a first end in fluid communication with a source of cryogen and a second end in fluid communication with the chamber for providing the cryogen to the chamber. A related system and method are also provided.

Abstract: A sample of produce wash water containing an antimicrobial sanitizer fluid, and a reference pathogen fluid are both injected into a pathogen inactivation region of a micro-fluidic mixer. The produce wash water (i.e. sanitizer fluid/pathogen fluid mix) is directed through mixer elements in the pathogen inactivation region of the micro-fluidic mixer. In the sanitizer deactivation region, a sanitizer deactivation solution is added to the sanitizer fluid/pathogen fluid mix to produce a deactivated solution. The deactivated solution is evaluated for the presence of the pathogen and the characteristics of the sanitizer. In the preferred embodiment, the sanitizer comprises chlorine and the pathogen comprises E. coli bacteria.

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

Abstract: The present invention relates to the use of surfaces that exhibit different surface energies wherein the difference in surface energies is configured to disrupt capillary laminar flow of a fluid travelling between the two surfaces. The invention further relates to the use of such surfaces in assay methods including a device utilising same.

Abstract: A blender includes a container having a plurality of ribs projecting into a processing zone of the container. The plurality of spaced ribs each include a width and a depth that taper from a top end section adjacent a teardrop shaped opening of the container to a more narrow bottom end section adjacent a bottom wall of the container. A side wall of the container continuously tapers from the teardrop shaped opening to a substantially square shaped bottom end portion including first, second, third and fourth side wall sections connected to one another at respective rounded corners. A blade assembly is coupled to the container and includes a plurality of blades angled at different planes with respect to a horizontal plane. The blender container further includes a handle adapted to receive a handle of a similar blender container, such that like blender containers can be nested for storage.

Abstract: A liquid receptacle has an inner vessel for holding a liquid, an insulated outer shell spaced from the Miler vessel, and a chamber defined between the inner vessel and the outer shell. A phase change material is disposed in the chamber for absorbing thermal energy from the liquid and then releasing the thermal energy back to the liquid to maintain the temperature of the liquid.

Abstract: Provided is a method of mixing fluids including introducing at least two kinds of fluids to a chamber of a substrate including a microchannel structure; and alternately rotating the substrate clockwise and counter-clockwise until the at least two kinds of fluids are mixed, wherein the rotation is changed from one direction to the opposite direction before a vortex created in the mixing chamber by the one direction rotation disappears.

Abstract: A layer multiplication device may include a housing and at least one layer multiplication insert positioned inside the housing. The housing may have an inlet configured to receive a flow stream, an outlet configured to discharge the flow stream, and a flow cavity extending between the inlet and the outlet. In operation, the layer multiplication insert may divide an incoming flow stream so as to multiply the flow stream into at least a first flow stream and a second flow stream. In some examples, the inlet provides an inlet flow volume equal to a cross-sectional area of the housing at the inlet multiplied by a length of the flow cavity, the flow cavity defines a cavity flow volume, and the cavity flow volume is equal to or greater than the inlet flow volume.

Abstract: A foaming mechanism configured to receive a plurality of streams of gas and generate a foamed liquid, having an aerodynamic component and an aerodynamic housing disposed around at least a portion of the aerodynamic component. The aerodynamic housing includes a plurality of first channels and a plurality of second channels connected to the plurality of first channels at regular intervals on a distributed plane. The distributed plane is about perpendicular to the plurality of first channels, wherein the plurality of first channels and the plurality of second channels are configured to transform an axial stream of the gaseous working agent into a plurality of radial high-speed streams of the gaseous working agent by channeling the gaseous working agent through the plurality of first channels and into the plurality of second channels on the distributed plane.

Abstract: A method of manipulating particles suspended within a fluid droplet using a microfluidic system including a piezo-electric substrate (1) and a wave generation means (3) for generating a wave within the piezoelectric substrate (1), and a working surface (2) through which the wave can be distributed and upon which fluid droplets (9) can be located, the method including locating one or more droplets of fluid on the working surface (2), varying the power applied to the wave generation means (3) or varying the distribution of the wave across the working surface (2), such that particles (1 1) suspended within the fluid droplet (9) are either dispersed within the droplet or concentrated in an area within the droplet in dependence on the power or wave distribution applied by the wave generation means (3) to the piezoelectric substrate (1), or to facilitate rotation of the fluid within said fluid droplets (9) located jn the path of the wave.

Abstract: To promote mixture of fluids on a plurality of stages, flow channels include a plurality of merging portions which penetrate from a top surface to a back surface of a substrate. An end of each of the sub channels is disposed so as to overlap the main channel at each of positions separated along the direction in which the main channel extends, and each of the merging portions communicates the main channels and the ends of the sub channels with each other, thereby changing a flow direction of the second fluid flowing through the sub channels to the thickness direction of the substrate, and merges the second fluid with the first fluid flowing through the main channels.

Abstract: A method of mixing magnetic particles (3) in a reaction chamber (2) that is part of a microfluidic device and that contains the said particles in suspension, comprises the steps: (a) providing an electromagnetic means (1,1?,6,7) to generate magnetic field sequences having polarity and intensity that vary in time and a magnetic field gradient that covers the whole space of the said reaction chamber (2); (b) applying a first magnetic field sequence to separate or confine the particles (3) so the particles occupy a sub-volume in the volume of the reaction chamber (2); (c) injecting a defined volume of the said reagent in the reaction chamber; and (d) applying a second magnetic field sequence to leads the particles (3) to be homogenously distributed and dynamically moving over a substantial portion of the whole reaction chamber volume.

Abstract: A high impact pressure processor comprises of a piston. The piston comprises of a piston seal, a piston cap, a piston shaft, and a plurality of vent holes. The piston seal, located at an end of the piston shaft, seals out air from a container of a food processor or blender. This enables high impact pressure to be placed on the ingredient(s) in the container, thus creating smoother and thicker mixtures of ingredient(s). The plurality of vent holes allows air into container when needed, but are easily sealed off with the piston cap.

Abstract: A method for recovering hydrocarbons from an aqueous hydrocarbonaceous slurry comprises pumping a mixture of the slurry and an oxidizing agent through a conduit, wherein the conduit comprises a plurality of stationary interior projections defining a non-linear path through the conduit, and thereby agitating the mixture to release the hydrocarbons from the slurry; and separating the hydrocarbons from the slurry.

Abstract: An advanced hydrodynamic cavitation device formed from a cylindrical tube having a flow through chamber. The chamber has a series of stages with each stage formed from at least three plates spaced annularly and extending radially inward at an oblique angle with respect to the longitudinal axis of the flow through chamber. Each plate has shear inducing side edges and a plurality of orifices with shear inducing edges. The orifices are arranged perpendicular to the plates and shaped to control the velocity of the fluid. An unrestricted passageway exists along the central axis of the flow through chamber to provide a constant flow for continuous flushing of suspended solids to prevent clogging. Additionally, the passageway will facilitate the insertion of a pressure cleaning tube without requiring that the device be disassembled.

Abstract: A micro-mixer and use thereof for synthesis of barium sulfate particles is disclosed. The micro-mixer includes feeding tubes, reservoirs, a mixing channel, a buffer reservoir and a sampling tube. The mixing channel is made of hydrophobic materials and processed into a spiral structure, in which baffles are set in interval arrangement at both sides of the channel wall. The types of the baffles include leaning-forward baffles, vertical baffles and leaning-backward baffles. Setting the baffles helps produce local secondary flow in the mixer, which enhances fluids mixing process. The micro-mixer is suitable to rapid reactions or precipitation processes, whose reaction time is much less than mixing time, and has broad application prospects in many fields involving mixing reaction such as pharmaceutical and chemistry industry.

Abstract: A device for manipulating and mixing magnetic particles (3) in a surrounding liquid medium, comprises at least one couple of magnetic poles (1,1?) facing each other across a gap, the facing poles diverging from a narrow end of the gap to a large end of the gap, the poles (1,1?) forming part of an electromagnetic circuit and being arranged to provide a magnetic field gradient in the gap region; and a reaction chamber (2) that is a part of a fluidic network for containing the said magnetic particles in suspension and placed in the gap of the said electromagnets poles (1,1?). The reaction chamber (2) preferably has at least one part which has a diverging cavity, arranged co-divergently in the diverging gap between the poles.

Abstract: Plasticizing system for plasticizing solidified-resin particle, plasticizing system, comprising: housing assembly providing: (i) melt channel configured to receive solidified-resin particle, and (ii) opposite-facing surfaces spaced apart from each other, and defining, at least in part, convergene channel configured to receive the solidified-resin particle. Opposite-facing surfaces and the convergence channel form part of melt channel. Plunger assembly is movable, at least in part, relative to opposite-facing surfaces. Plunger assembly configured to move, at least in part, solidified-resin particle relative to opposite-facing surfaces along, at least in part, convergence channel. In response to relative movement between solidified-resin particle and opposite-facing surfaces, solidified-resin particle receives, in use, plasticization-inducing effect from opposite-facing surfaces.

Abstract: A method for continuous production of radiation curable ink suitable for ink-based digital printing includes feeding ingredients suitable for forming a pigment concentrate to an extruder; blending the ingredients in the extruder to form a pigment concentrate paste; feeding additional ingredients to the extruder for blending with the ink concentrate to form an ink product configured for ink-based digital printing, wherein a pigment particle size is less than about 1 micron.

Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).

Abstract: Plural types of fluids that are incompatible with each other are merged. A disturbance is induced at an interface between the fluids by causing the fluids to flow through a merged flow passage having a cross-sectional area that changes. One type of the fluids is turned into microscopic liquid droplets.

Abstract: This invention relates to a mixing device for an aircraft air conditioning system with a supply conduit for fresh air from the air conditioning system, with a second supply conduit for recirculated air from a pressurized region of the aircraft, and with a discharge conduit for supplying mixed air into the pressurized region of the aircraft, wherein a non-return valve is integrated in the mixer.

Abstract: Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include a mixing structure formed within a body, wherein fluid flowing through the mixing structure defines a downstream direction through the mixing structure. The mixing structure includes a series of Y-shaped channels that cross to provide flowpaths that result in efficient mixing.

Abstract: A mixing unit and various applications of the mixing unit are described herein. The mixing unit includes: a stacked member in which three or more mixing elements are stacked; and a first plate and a second plate between which the stacked member is sandwiched and which are arranged opposite each other. In the mixing unit, the mixing elements have a plurality of first through holes, the second plate has an opening portion communicating with at least one of the first through holes in the mixing elements and the mixing elements are arranged such that part or all of the first through holes in one of the mixing elements communicate with other first through holes in the adjacent mixing element to allow fluid to be passed in a direction in which the mixing elements extend.

Abstract: This invention provides microfluidic devices that comprise a fluidics layer having microfluidic channels and one or more regulating layers that regulate the movement of fluid in the channels. The microfluidic devices can be used to mix one or more fluids. At least a portion of the fluidics layer can be isolated from the regulating layer, for example in the form of a shelf. Such isolated portions can be used as areas in which the temperature of liquids is controlled. Also provided are instruments including thermal control devices into which the microfluidic device is engaged so that the thermal control device controls temperature in the isolated portion, and a movable magnetic assembly including magnets with shields so that a focused magnetic field can be applied to or withdrawn from the isolated portion or any other portion of the microfluidic device. Also provided are methods of mixing fluids.

Abstract: A device for applying a coating includes a multi-component cartridge, a static mixing nozzle in fluid communication with the cartridge, and at least one paint applicator selected from the group including a roller, a brush, and an angled spray tip, in fluid communication with the nozzle. A method includes applying a coating to a surface with the above-described device. Another method includes applying a non-skid coating to a surface with the above-described device.

Abstract: The invention concerns a process for the continuous treatment of an emulsion and/or a micro-emulsion assisted by an “expanded liquid” for the production of micro- and/or nano-particles or micro- and/or nano-spheres containing one or more active ingredients. In particular, a liquid solvent expanded by compressed or supercritical CO2 is contacted with an O/W emulsion, or alternatively a W/O emulsion or multiple emulsions, formed by an external phase that is itself a liquid expanded by compressed CO2. The expanded liquid forms a solution with the dispersed phase of the emulsion and extracts it inducing the formation of the desired particles of the dissolved compounds. The process is carried out in a counter-current packed column wherein the expanded emulsion is fed from the top, while the expanded liquid is fed from the bottom. Thanks to the presence of the expanded liquid, any deposition of the solid particles produced on the packing elements is avoided, thus preventing any column blockage.

Abstract: A fluid micro-mixer and micro-reactor array is provided having at least two bonded layers of micro-channels. The micro-mixer can include at least one input port and one output port, and a mixing and/or reaction port. At least one inlet stream separator layer can isolate the inlet ports from one another.

Abstract: In order to provide, when a plurality of fluids each containing a different kind of substance are mixed and reacted, a reactor having a mixing channel capable of forming a multi-layered flow in a radial direction in the cylindrically-shaped mixing channel; improving mixing performance by synergizing swirling effects of mixture of turbulent flows and a swirling flow; and producing a reaction product with a high yield as well as high efficiency, a mixing channel 1 which mixes fluids 4 and 5 each containing the different kind of substance is cylindrically shaped, and inlet passages 2 and 3 which introduce the fluids 4 and 5, respectively, are plurally arranged in a manner offset from a central axis of the mixing channel 1.

Abstract: In a feed dilution system and method for a thickener or settling tank, a feed pipe nozzle has an outlet opening or orifice configured to generate an initial stream of slurry from the feed pipe into an upstream end of a mixing conduit wherein the stream is extended from a first side of the mixing conduit to a substantially opposite second side in a first direction transverse to the mixing conduit so as to enhance entrainment of dilution fluid flow into the slurry stream and concomitantly produce a substantially uniform solids concentration across a stream flowing from the mixing conduit into the feedwell. The outlet opening is generally shaped asymmetrically towards a third side of the mixing conduit in a second direction transverse to the mixing conduit so as to bias the initial stream of slurry towards the one side, where the second direction is substantially perpendicular to the first direction.

Abstract: A microfluidic device comprises at least one reactant passage defined by walls and comprising at least one parallel multiple flow path configuration comprising a group of elementary design patterns being able to provide mixing and/or residence time which are arranged in series with fluid communication so as to constitute flow paths, and in parallel so as to constitute a multiple flow path elementary design pattern, wherein the parallel multiple flow path configuration comprises at least two communicating zones between elementary design patterns of two adjacent parallel flow paths, said communicating zones being in the same plane as that defined by said elementary design patterns between which said communicating zone is placed and allowing passage of fluid in order to minimize mass flow rate difference between adjacent parallel flow paths which have the same flow direction.

Abstract: In order to dissolve cleaning tablets in a constant stream of media, a rinsing out chamber is suggested, in which the tablet is dissolved in an upward rotary stream of the medium, that keeps it afloat against a filter mesh.

Abstract: The invention generally relates to a mixing device. In certain embodiments, devices of the invention include a fluidic inlet, a fluidic outlet, and a chamber, the chamber being configured to produce a plurality of fluidic vortexes within the chamber.

Abstract: A microbe testing device includes a measurement cell for holding a sample liquid, and a rotor that is rotated, by magnetic force imparted from outside the measurement cell, along a bottom face in the sample liquid held in the measurement cell. The sample liquid is stirred by rotating the rotor so that only its end portions are in contact with the bottom face of the measurement cell.

Abstract: The present invention relates to a mug, especially a disposable mug, which mug defines an internal space for receiving liquid. It is significant for the mug according to the present invention that the mug contains a flap (10; 110) provided on the inside of the mug, that the flap (10; 110) extends along the inside of the mug in a non-active state, and that the flap (10; 110) reaches out from the inside of the mug in an active state of the flap (10; 110).

Abstract: A stand mixer and heating means combination apparatus includes a stand mixer that has a base. A top side of the base includes a container mating member. An outer container includes a mixer mating member that is engageable with the container mating member. The outer container includes a bottom wall. A heating assembly is mounted on the base and is in thermal communication with the outer container. An inner container has a lower wall. The inner container has a size to be positioned in the outer container. A first mating member is attached to an outer surface of the inner container and is engageable with a second mating member attached to an inner surface of the outer container such that the lower and bottom walls are retained in a spaced relationship with each other.

Abstract: An apparatus for feeding one or more chemicals into a process stream of a pulp process is disclosed, as well as a method of utilizing the apparatus for feeding one or more chemicals into a pulp process is disclosed.

Abstract: In one embodiment of the disclosure, a fluid mixing device comprises a flow duct, with a wall having an inner surface defining a fluid flow path for a primary flow, and at least one deployable and retractable projection. The projection is adapted to controllably generate at least one secondary flow adjacent the inner surface. In other embodiments, methods are provided of controllably mixing at least one fluid within a fluid mixing device.