Abstract: A malignancy classification method and medium for diagnosing a region of lung tissue based on MRI data are disclosed. The classifying includes: setting time points T1 and T2 measured from injection of a contrast agent. T1 represents a wash-in time point for malignant lung tissue at which a first concentration value of the injected contrast agent is substantially equal to or near a peak for injected contrast agent concentration in the region of lung tissue. Patient concentration values of the contrast agent for the area of lung tissue at time points T1 and T2 are obtained, and a malignancy classification for the region of lung tissue is provided by comparing the obtained sample concentration values with a predetermined malignancy profile. A visual representation of the malignancy classification of the region of lung tissue is outputted.

Abstract: One embodiment of the present disclosure sets forth a method for determining a movement of a target region using tomosynthesis. The method includes the steps of accessing a first set of projection radiographs of the target region over a first processing window defined by a first range of projection angles, accessing a second set of projection radiographs of the target region over a second processing window defined by a second range of projection angles, wherein the first processing window moves to the second processing window, and comparing a first positional information derived from the first set of the projection radiographs and a second positional information derived from the second set of the projection radiographs with the first positional information to determine the movement of the target region.

Abstract: In a method for the processing of radiological images for the detection of opacities in a radiography image, an algorithm is proposed for detecting opacities according to their contrasts. To determine a contrast that is not over-estimated in each element, an algorithm is proposed for computing the background intensity by means of a sliding-window filtering. This type of sliding-window filtering computes the set of mean values of grey levels about an immediate environment of a region of elements whose size depends on the size of the opacity to be detected. The algorithm considers a background intensity of the region of elements to be the lowest mean value grey levels among the set of mean values of grey levels.

Abstract: One embodiment of the present disclosure sets forth a method for determining a movement of a target region using tomosynthesis. The method includes the steps of accessing a first set of projection radiographs of the target region over a first processing window defined by a first range of projection angles, accessing a second set of projection radiographs of the target region over a second processing window defined by a second range of projection angles, wherein the first processing window slides to the second processing window during treatment of the target region, and comparing a first positional information derived from the first set of the projection radiographs and a second positional information derived from the second set of the projection radiographs with the first positional information to determine the movement of the target region.

Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.

Abstract: One embodiment of the present disclosure sets forth a method for determining a movement of a target region using tomosynthesis. The method includes the steps of accessing a first set of projection radiographs of the target region over a first processing window defined by a first range of projection angles, accessing a second set of projection radiographs of the target region over a second processing window defined by a second range of projection angels, wherein the first processing window slides to the second processing window during treatment of the target region, and comparing a first positional information derived from the first set of the projection radiographs and a second positional information derived from the second set of the projection radiographs with the first positional information to determine the movement of the target region.

Abstract: The present invention proposes a technique capable of accurately grasping position and angle of a radiation generator at the time of image capturing. At the time of obtaining a plurality of transmission images by detecting radiation emitted from a emitting generator and passing through a specimen via a predetermined member (for example, a diaphragm) by a detector for a plurality of times while changing a relative position relation and a relative angle relation of the emitting generator to the detector, an outer-edge shape of a radiation area irradiated with the radiation on a detection surface of the detector from the emitting generator is recognized. On the basis of the outer-edge shape of the radiation area and an inner-edge shape of a predetermined member, the relative position relation and the relative angle relation of the emitting generator to the detector are obtained.

Abstract: A method and a system for using tomosynthesis projection images of a patient's breast to reconstruct slice tomosynthesis images such that anatomical structures that appear superimposed in a mammogram are at conforming locations in the reconstructed images.

Abstract: A method is disclosed for production of computer-tomographic scans via a CT system of a patient during an intervention with an instrument. An X-ray tube is moved on a rotation plane around the patient in order to produce a beam cone, and a detector with a plurality of detector elements measuring the radiation intensity after passing through the patient. Computer-tomographic scans are reconstructed from the measured values in a computation unit. The central direction of the beams of the scanning beam cone is set at an angle to the intervention axis, and at least one slice plane which differs from the rotation plane of the beam cone is displayed on a display.

Abstract: A method and system for acquiring, processing, storing, and displaying x-ray mammograms Mp tomosynthesis images Tr representative of breast slices, and x-ray tomosynthesis projection images Tp taken at different angles to a breast, where the Tr images are reconstructed from Tp images.

Abstract: A method of detecting the extent of a lung nodule in a scan image comprises fine segmenting (14) a region around the nodule into foreground and background, filling holes within foreground areas (16), region growing the foreground (18) to identify an initial region of interest, determining a mask (20) by enlarging the initial region to contain background and to exclude other foreground regions, determining a spatial map (26) of connectivity within the mask to a point within the initial region, region growing (28) within the mask and determining the maximum edge contrast (30) during region growing. The region of maximum edge contrast identifies the extent of the nodule (32). The position of the nodule may a seed point identified by the user (12). Most preferably, an optimum seed point is determined by iterative determination of seed points (22, 24) so that the determined extent of the nodule is substantially independent of the precise location of the seed point identified by the user.

Abstract: A detector module, in at least one embodiment, is disclosed for x-radiation or gamma radiation that includes one or more optical waveguide sections that are arranged next to one another in order to form one or more detector rows and are optically interconnected in serial fashion. The waveguide sections include one or more converter materials for converting incident x-radiation or gamma radiation into optical radiation and are designed in such a way that optical radiation of different wavelength is generated in respectively neighboring regions along the waveguide sections upon incidence of x-radiation or gamma radiation. The present detector module, in at least one embodiment, can be implemented cost effectively with a high number of detector rows, and is of very low weight.

Abstract: A tomosynthesis system for forming a three dimensional image of an object is provided. The system includes an X-ray source adapted to irradiate the object with a beam of X-rays from a plurality of positions in a sector, an X-ray detector positioned relative to the X-ray source to detect X-rays transmitted through the object and a processor which is adapted to generate a three dimensional image of the object based on X-rays detected by the detector. The detector is adapted to move relative to the object and/or the X-ray source is adapted to irradiate the object with the beam of X-rays such that the beam of X-rays follows in a non arc shaped path and/or a center of the beam of X-rays impinges substantially on the same location on the detector from different X-ray source positions in the sector.

Abstract: A method and device for image processing to determine image characteristics includes operations of segmenting of first images to create segmentation contours corresponding to the first images; and registering the segmented first images to second images. Further, operations of transferring the segmentation contours from the first images to second images; and fitting the transferred segmentation contours in the second images are performed.

Abstract: When radiographic images are obtained by radiography using a tomographic image obtainment apparatus, the degree of overlap of anatomical structures of a subject is obtained. Further, a condition of exposure, such as angles ? of radiography, is changed based on the degree of overlap. The angles ? of radiography are angles at which a radiation irradiation unit performs radiography at a plurality of positions to obtain a plurality of radiographic images. The tomographic image obtainment apparatus produces a tomographic image by reconstructing the tomographic image from a plurality of radiographic images obtained by irradiating the subject with radiation from various directions.

Abstract: When radiographic images are obtained by radiography using a tomographic image obtainment apparatus, the degree of overlap of anatomical structures of a subject is obtained. Further, a condition of exposure, such as angles ? of radiography, is changed based on the degree of overlap. The angles ? of radiography are angles at which a radiation irradiation unit performs radiography at a plurality of positions to obtain a plurality of radiographic images. The tomographic image obtainment apparatus produces a tomographic image by reconstructing the tomographic image from a plurality of radiographic images obtained by irradiating the subject with radiation from various directions.

Abstract: The invention relates to a coordinate measuring apparatus (110) for measuring an object (3), comprising an x-ray sensory mechanism as a first sensory mechanism that is provided with an x-ray source (10) and at least one x-ray sensor (7) which detects the x-rays, and a second sensory mechanism such as a tactile and/or an optical sensory mechanism (8, 11; 9) that can be placed in the x, y, and/or z direction of the coordinate measuring apparatus in relation to the object. In order to be able to easily measure also large-size test objects, the x-ray sensory mechanism (7, 10) can be positioned in the coordinate measuring apparatus (10) according to the second sensory mechanism (8, 11; 9).

Abstract: A system and method are provided which enable parallel image reconstruction of multiple depth layers of an object. More specifically, a system and method are provided in which pixels are captured for an object and such pixels are processed to reconstruct voxels for multiple depth layers of the object in parallel. In one embodiment, a reconstruction processor comprises at least one input port for receiving pixels of a radiographic image of an object, and at least one input port for receiving position data associated with a received pixel. It further comprises processing logic operable to determine, based at least in part on the received position data of a received pixel, a first and second voxel of a first and second layer of the object, respectively, to which the received pixel contributes, and further operable to apply the contribution of the received pixel to the first and second voxels in parallel.

Abstract: A technique is provided for segmenting a structure of interest from a volume dataset. The technique identifies regions of the structure using templates having characteristics of the structure of interest. The identified regions may then undergo a constrained growth process using dynamic constraints that may vary based on local statistics associated with the identified structure regions. Edges within the volume may be determined using gradient data determined by evaluating the strongest gradient between each pixel and all adjacent pixels. The edge data may be used to prevent the constrained growing process from exceeding the boundaries of the structure of interest.

Abstract: A novel X-ray apparatus is provided for three-dimensional imaging and in particular for tomosynthesis examination, which includes an X-ray source having a focal spot, a collimator including a plurality of slits, a detector assembly including a plurality of line detectors corresponding to respective ones of the plurality of slits and an exposure volume arranged between the collimator and the detector assembly. The X-ray source, the collimator and the detector assembly are arranged in series, so that each line detector is aligned with the corresponding collimator slit and the focal spot, and is simultaneously displaceable by a scan motion relative to the exposure volume. The scan motion is primarily a rotation around a rotation axis arranged such that the detector assembly is situated essentially between the rotation axis and the X-ray source. Combined two and three-dimensional examination are also permitted according to the disclosed methods and apparatus.

Abstract: A first controller synthesizes image output of a CCU and a cursor created based on trigger information from a second controller, following location information. The synthesized image is displayed on a first monitor, so an endoscope image and a cursor image which moves synchronously with the cursor image on a display device can be simultaneously viewed at the surgery room side on a single monitor, and accordingly, the problem of the working space inside the surgery room becoming crowded due to providing multiple observation monitors in the surgery room does not occur.

Abstract: A method for displaying a computer-generated determination of the likelihood of malignancy in a mammogram lesion. The method requires providing a digitized image of a mammogram, displaying the digitized image, and selecting a region of interest directly on the displayed digitized image. The digitized image is then processed so that classifier data of the lesion in the user-selected region of interest are generated and displayed. A system for displaying a determination of the likelihood of malignancy in a mammogram lesion. The system includes a display for presenting a digitized mammogram and an input device in communication with the display for selectably indicating a region of interest on the displayed mammogram. The system also includes a processor for generating classifier data related to a characterization feature within the region of interest. The classifier data is presented on the display.

Abstract: A scanning-based apparatus for obtaining tomosynthesis data of an object performing a periodic movement comprises a radiation source emitting radiation around an axis of symmetry; a radiation detector comprising line detectors, each being directed towards the divergent radiation source to allow a ray bundle of the radiation that propagates in a different angle to enter the line detector after having been transmitted through the object, and to be detected repeatedly therein; and a movement device provided for moving the radiation source and the radiation detector relative to the object linearly in a path orthogonal to the symmetry axis, and a distance which is sufficient for scanning each of the line detectors across the entire object. The movement device is provided to repeat the movement a plurality of times, each time with a different phase shift relative to the periodic movement of the object.

Abstract: A tomosynthetic image taking apparatus takes an x-ray image of an object in each of a plurality of positions of an x-ray source to obtain a desired tomogram of the object by adding up the x-ray images thus obtained. A heartbeat phase is detected and the tomosynthetic image taking apparatus is controlled to take an x-ray image of the object in each of the plurality of positions of the x-ray source when the heartbeat of the object is in the same heartbeat phase.

Abstract: A tomosynthesis system for forming a three dimensional image of an object is provided. The system includes an X-ray source adapted to irradiate the object with a beam of X-rays from a plurality of positions in a sector, an X-ray detector positioned relative to the X-ray source to detect X-rays transmitted through the object and a processor which is adapted to generate a three dimensional image of the object based on X-rays detected by the detector. The detector is adapted to move relative to the object and/or the X-ray source is adapted to irradiate the object with the beam of X-rays such that the beam of X-rays follows in a non arc shaped path and/or a center of the beam of X-rays impinges substantially on the same location on the detector from different X-ray source positions in the sector.

Abstract: A method and apparatus for reconstructing an image of an organ or body part from at least two images of the organ or body part taken using radiography in two positions of the organ or body part separated by a rolling movement of the organ or body part. The rolling movement of the organ or body part is determined between two positions, extracting motion vectors for the surface of the organ or body part, interpolating motion vectors between the motion vectors extracted, and reconstructing an image of the organ or body part. The method and apparatus allows the three-dimensional structure of the tissue to be reconstructed while reducing ambiguities due to the presence of a lesion overlaying the tissue.

Abstract: A method of cardiac radiological examination for coronarography comprises the steps of: a) introducing contrast medium simultaneously in the left coronary artery and in the right coronary artery from the aortic root and, in parallel, b) acquiring a sequence of dynamic images of the propagation of the contrast medium in the left and right coronary arteries with a displacement of the image plane, during the acquisition of said images, along a determined trajectory (E28). The contrast medium can be introduced in a cyclic manner during the acquisition of dynamic images, each cycle of introduction corresponding to a phase of closure of the aortic valve in the cardiac rhythm. 3D and 4D images with optimal efficiency can be obtained in the use of contrast medium. An injection device for producing the above cycles is synchronized with the introduction of the contrast medium.

Abstract: Image processing method for displaying an image sequence of a deformable 3-D object with indications of the object wall motions comprising steps of acquiring image data of an image sequence, segmenting the 3-D object in the images of the sequence for locating the wall of the 3-D object, and coloring voxels or parts of the wall in function of their displacement with respect to the wall of the 3-D object in one image of the sequence chosen as a reference. Color images of the 3-D object with color coded voxels or parts of the wall are displayed in a sequence for the user to estimate the object wall motion. This method is used in medical examination apparatus for studying ultrasound images of organs whose walls have motion.

Abstract: An apparatus for obtaining tomosynthesis data of an object comprises a source emitting radiation centered around an axis of symmetry; a radiation detector comprising a stack of line detectors, each being directed towards the source at a respective angle; and a device for moving the source and the radiation detector relative the object linearly in a direction orthogonal to the symmetry axis, while each of the line detectors is adapted to record line images of radiation as transmitted through the object in the respective angle. A device is provided for rotating the radiation detector around a rotation axis orthogonal to the symmetry axis, and the device for moving is further arranged to repeat the essential linear movement of the source and the radiation detector relative the object, while each of the line detectors is adapted to record a further plurality of line images of radiation as transmitted through the object.

Abstract: A method for obtaining a reconstruction of a tomographic dataset by filtering and combining the projection images, followed by a backprojection step. In one embodiment, the method can yield a reconstruction equivalent to an additive ART reconstruction, while in another embodiment the method represents a filtered back-projection type reconstruction. The computations do not require an iterative backprojection/re-projection step.

Abstract: A technique is provided for non-uniform weighting in back-projection calculations in tomosythesis. The non-uniform weighting may include weighting based on a count map of the number of times pixels of individual slices are traversed by radiation in different projections. Weighting may also include non-uniform functions for contributions of features at different slice level to the sensed X-ray attenuation system response inconsistencies are accounted for by further weighting based upon projection maps which may be created in separate system calibration or configuration routines.

Abstract: Processing of up to a plurality of radiographic images of a subject, includes the capture of at least two visible light images of the subject, two or more of the visible light images in correspondence to at least one radiographic image. The visible light images are captured by one or more visible light cameras, each visible light camera in a known geometric relation to the radiographic source. Radiographic geometry of each radiographic image is calculated relative to the radiographic source and the subject through stereoscopic analysis of the visible light images and through reference to the known geometric relation between the one or more visible light cameras and the radiographic source. Three-dimensional radiographic information on the subject is generated and manipulated by processing the up to a plurality of radiographic images based on the recovered radiographic geometry.

Abstract: The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.

Abstract: An imaging system for performing tomosynthesis on a region of an object comprises an x-ray source, motion controller, an x-ray detector and a processing unit. The x-ray source is positioned at a predetermined distance from the object and continuously moves along a path relative to the object at a plurality of predetermined locations. The x-ray source transmits x-ray radiation through the region of the object. The motion controller is coupled to the x-ray source and continuously moves the x-ray source along the path relative to the object. The x-ray source minimizes vibration in the imaging system due to continuous movement. The x-ray detector is positioned at a predetermined distance from the x-ray source and detects the x-ray radiation transmitted through the region of the object, thus acquiring x-ray image data representative of the region of the object. The processing unit is coupled to the x-ray detector for processing the x-ray image data into at least one tomosynthesis image of the region of the object.

Abstract: A ray tracing kernel calibration procedure for the film simulation mode of digitized tomosynthesis in which the coordinate of the source position with respect to an energy source, e.g., x-ray radiation, is determined. Shadow images of registration markers are used to aid in computing the azimuth; computing the elevation angle; and using the elevation angle and azimuth to compute the coordinate of source position with respect to the sensor.

Abstract: A tomosynthesis system for scanning a region in an object comprises a radiation source configured to traverse in a plurality of positions yielding a plurality of scanning directions. Each of the plurality of positions corresponds to a respective scanning direction. Further, the plurality of scanning directions comprise at least a scanning direction along a first axis and a direction along a second axis, the second axis being transverse to the first axis.

Abstract: The invention provides novel scale-based filtering methods that use local structure size or “object scale” information to arrest smoothing around fine structures and across even low-gradient boundaries. One method teaches a weighted average over a scale-dependent neighborhood; while another employs scale-dependent diffusion conductance to perform filtering. Both methods adaptively modify the degree of filtering at any image location depending on local object scale. This permits a restricted homogeneity parameter to be accurately used for filtering in regions with fine details and in the vicinity of boundaries, while at the same time, a generous filtering parameter is used in the interiors of homogeneous regions.

Abstract: A digital tomosynthesis system acquires a plurality of projection radiographs of an object and reconstructs structures of the object based on the acquired projection radiographs. The digital tomosynthesis system includes an x-ray source and a detector. The x-ray source emits a beam of x-rays, and moves in a linear trajectory relative to the detector.

Abstract: The invention relates to a method of imaging a vascular tree that yields additional information concerning the vascular tree. To this end, a sequence of clusters is determined from spatially coherent voxels in the three-dimensional image of the vascular tree, the sequence of said clusters corresponding to the flow direction of the blood or the contrast medium in said vascular tree.

Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.

Abstract: A system and method for producing three-dimensional representations of an object. A first series of projected images of the selected object is recorded in a first projection plane and a second series of projected images of the selected object is recorded in a second projection plane. The first and the second series of projected images are rendered at a common magnification. The first set of projected images is then integrated into a first three-dimensional volume and the second set of projected images is integrated into a second three-dimensional volume. The three-dimensional representation of the object is then produced by combining one projected image from the first set of projected images with one projected image from the second set of projected images. Alternatively, the three-dimensional representation is produced by merging the first three-dimensional volume with the second three-dimensional volume.

Abstract: A tomosynthesis system for forming a three dimensional image of an object is provided. The system includes an X-ray source adapted to irradiate the object with a beam of X-rays from a plurality of positions in a sector, an X-ray detector positioned relative to the X-ray source to detect X-rays transmitted through the object and a processor which is adapted to generate a three dimensional image of the object based on X-rays detected by the detector. The detector is adapted to move relative to the object and/or the X-ray source is adapted to irradiate the object with the beam of X-rays such that the beam of X-rays follows in a non arc shaped path and/or a center of the beam of X-rays impinges substantially on the same location on the detector from different X-ray source positions in the sector.

Abstract: In a radiation tomography device, in case a wide photographing area is required, even if a resolution capability in a depth direction of a section of a subject including an intersection of a rotation axis and a radiation irradiating axis is low, a small Laminographic angle &agr;1 is set. In case a high resolution capability is required in the depth direction, even if the photographing area is narrow, a large Laminographic angle &agr;2 is set. Since a balance between the resolution capability in the depth direction of the subject and the photographing area can be adjusted by varying the Laminographic angle, the photographing modes can be freely selected to thereby carry out the tomography suitable for the photographing requirement.

Abstract: A radiographic apparatus or system for imaging a dynamic state or process of an object such as a human body includes an indication unit for performing dynamic state guiding indication using a perceivable pattern corresponding to a dynamic state or motion to be engaged in by the patient, and an image acquisition unit for acquiring a plurality of radiographs of the human body. The resulting radiographs can be reviewed for diagnosis, and can be stored, either locally or at a remote location.

Abstract: An X-ray device for the formation of slice images of an object to be examined including an X-ray source, an X-ray detector, a transport device for moving the object during the acquisition of a series of X-ray projection images of the object in a movement plane situated parallel to the imaging plane, and a control device for controlling the acquisition of the X-ray projection images and the transport device. Slice images of the object are formed from the X-ray projection images by a tomosynthesis method.

Abstract: The present invention provides a method and system for determining the position of the image of a target object or the position of the x-ray source in digital tomosynthesis, as the x-ray source is moved relative to the object so as to obtain multiple two-dimensional images of the object from multiple angles. At least one marker, characterized by a simple and known image pattern, is disposed between an x-ray source and a detector system. The shift in the image of the object, resulting from the movement of the x-ray source during tomosynthesis, is calculated to a desired resolution using the readily observable shift in the image of the marker. The x-ray source may be translated along a plane parallel to the plane of the detector system, or may be rotated about a fixed center.

Abstract: In a method and CT apparatus for producing CT images of a body region periodically moving with resting or motion phases, data corresponding to a number of projections serving the purpose of imaging are analyzed to determine whether each projection was acquired during a resting or motion phase, and only those data that were acquired during a resting phase are employed for image reconstruction.

Abstract: An apparatus and method are provided for obtaining x-ray tomosynthesis data desirable for mammography. The apparatus operates in conjunction with gravity to quickly and smoothly move an x-ray source through a plurality of positions relative to a stationary digital detector and a patient's breast to obtain a plurality x-ray images of the patient's breast which can then be processed for examination by a physician or radiologist. In one embodiment, an actuator such as a hydraulic system is operably connectable to the radiation source to controllably allow the radiation source to move under the influence of gravity from an elevated position to a lower position relative to the digital detector.

Abstract: A method for determining a time for acquiring contrast-enhanced images from a CT scanner of a subject into whom a contrast medium has been injected, the method including: identifying a region of interest in an initial CT image of the body of a subject; defining an attenuation data segment corresponding to the region of interest by reprojecting the region of interest in the initial image; receiving attenuation data within the segment from a subsequent scan of the patient; and independently processing the attenuation data received within the segment to estimate an optimal time for performing a diagnostic scan of the body, without reconstructing all or a portion of the CT image.

Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.