Specific Application Patents (Class 378/1)
  • Patent number: 10241173
    Abstract: Systems and methods for acquiring magnetic resonance fingerprinting (MRF) imaging data from a subject using a magnetic resonance imaging (MRI) system are provided. The method includes receiving an indication of an MRF imaging process to be performed by the MRI system and receiving a desired design objective for the MRF imaging process and a configuration metric associated with the MRF imaging process. The method further includes using the configuration metric to bound a variance of tissue parameter estimates associated with the MRF imaging process and determine imaging parameters that achieve the desired design objective. The method also includes performing the MRF imaging process using the determined imaging parameters to acquire MRF data using the MRI system.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: March 26, 2019
    Assignees: The General Hospital Corporation, The University of Southern California
    Inventors: Bo Zhao, Justin P. Haldar, Lawrence Wald
  • Patent number: 9898817
    Abstract: What is disclosed is a software tool which enables medical practitioners to manually or automatically analyze a thermal image of an area of breast tissue for the presence of tumorous tissue. In one embodiment, the software interface tool disclosed herein comprises a patient details object which enables the display of a patient details screen wherein a user can enter/edit patient information. A thermal analysis object enables a user to analyze a displayed thermal image of a breast of a patient for breast cancer screening and to classify tissue identified in the thermal image as being tumorous. A modalities object concludes the patient evaluation, persists all data collected from other sections of the tool, and generates reports for documentation purposes. The information can be captured from a database and edited and analyzed further using the tool. Also, report containing all the relevant data is generated for doctor's reference.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: February 20, 2018
    Inventors: Gayatri Sivakumar, Shubhi Sharma, Himanshu J. Madhu, Arun Koushik Parthasarathy, Krithika Venkataramani, Siva Teja Kakileti
  • Patent number: 9720938
    Abstract: A feature amount calculation unit 61 calculates a feature amount corresponding to a pattern of a lesion by analyzing an inspection image. A probability calculation unit calculates a first existence probability which is a probability of the pattern of a lesion existing within the inspection image, using a calculation expression. The calculation expression is created in advance by a statistical method on the basis of a relationship between the feature amount and the presence or absence of the pattern of a lesion within an image for learning which is visually determined by a person. A similarity calculation unit calculates a similarity between the inspection image and a case image on the basis of the first existence probability and a second existence probability which is a probability of the pattern of a lesion existing within the case image which is calculated by the statistical method similarly to the first existence probability.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: August 1, 2017
    Assignee: FUJIFILM Corporation
    Inventor: Shoji Kanada
  • Patent number: 9689811
    Abstract: A scanning transmission x-ray imaging system includes an x-ray source producing x-rays at a focal spot and moving about a source movement axis passing through the focal spot, x-ray detector arrays each detecting x-rays from the x-ray source along a detector dimension, and a collimator between the source and the arrays, fixed to the source, and defining slits to collimate the x-rays into a set of linear x-ray beams. The arrays are spaced from the source such that the linear x-ray beam at each of the arrays has the linear x-ray beam substantially impact within a height and width of a respective one of the arrays. The arrays move correspondingly with the source such that each of the linear x-ray beams remain aligned with a respective one of the arrays.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: June 27, 2017
    Assignee: Visuum, LLC
    Inventors: John D. Cox, James Gimlett, Shaun Georges, David Cleaves
  • Patent number: 9642589
    Abstract: Systems and methods are provided that receive a clinical identifier, an acquisition condition target, and one or more patient characteristics. The systems and methods further generate a scan attribute based on the clinical identifier. The scan attribute corresponding to characteristics of a resultant medical image. The systems and methods determine select scan settings from a plurality of scan settings based on the scan attribute and the one or more patient characteristics, and calculate candidate acquisition conditions associated with the select scan settings. Further, the systems and methods identify one of the select scan settings as a scan prescription based on a relation between the candidate acquisition conditions and the acquisition condition target.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: May 9, 2017
    Assignee: General Electric Company
    Inventors: Mark Vincent Profio, Darin Robert Okerlund, Scott D. Slavic, Bradley Jay Gabrielse, Priti Madhav
  • Patent number: 9513385
    Abstract: An x-ray scanner includes an x-ray source producing a fan beam of x-rays, an x-ray detector array, a collimator, a second motor moving TDI detector arrays, and an x-ray processing unit. The detector array has the TDI arrays and detects x-rays from the source. The collimator disposed between the source and detector array defines slits to collimate the fan beam of x-rays into lateral beams with a height dimension the same as a height dimension of the TDI detector arrays. Either the collimator is fixed to the x-ray source or moves thereto. A first motor moves the collimator or the collimator and source together. The processing unit controls the motors, processes detection of the x-rays, and forms an image of an entity between the collimator and the detector array to have an intensity and contrast of the scanned image be maximized while an exposure dose for the entity is minimized.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: December 6, 2016
    Assignee: Visuum, LLC
    Inventor: John D. Cox
  • Patent number: 9495772
    Abstract: CT imaging systems and methods thereof are disclosed. A common CT scanning is performed on an object to obtain a common CT imaging. An area of interest is determined from the image. A CT scanning is performed on the area of interest under a plurality of energy windows by a photon counter detector. A high resolution image of the area of interest is reconstructed. The discrimination of energy spectrum is higher and the result so obtained is more stable by using a photon counter detector to collect photon count projection data of a plurality of energy windows and thus it may be decomposed into a plurality of basis functions.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: November 15, 2016
    Assignees: NUCTECH COMPANY LIMITED, TSINGHUA UNIVERSITY
    Inventors: Le Shen, Yuxiang Xing, Yuanji Li, Chuqing Feng, Li Zhang, Zhiqiang Chen
  • Patent number: 9259192
    Abstract: A radiation tomography apparatus is provided. The radiation tomography apparatus is configured to display a dose near a surface of a subject.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: February 16, 2016
    Assignee: General Electric Company
    Inventor: Yotaro Ishihara
  • Patent number: 9198270
    Abstract: A radiation imaging apparatus includes a console that houses control circuitry and a computer; a radiation source attached to a movable arm, the movable arm being attached orthogonally to a column disposed adjacent to the console; and a wireless communication system that can communicate with a wireless radiation detector. The wireless communication system includes a plurality of antennas each of which is disposed within a predetermined distance from each other; the computer controls the communications system and the radiation detector so that the antennas transmit control signals from the console to the radiation detector or receive image signals from the radiation detector, and the antennas are positioned either within console immediately below a housing thereof or around the column so as to face a usable patient area, the usable patient area being an area surrounding the console where the radiation detector is positioned during an imaging operation.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: November 24, 2015
    Assignee: Virtual Imaging, Inc.
    Inventors: Peter M. Chicchetti, Carmine Pizzuto, Christopher Duca, Freddie Lang
  • Patent number: 9066687
    Abstract: A panoramic dental x-ray unit. The unit includes a support rotating about an axis and carrying, in the opposite position, an x-ray source and detector which move following a predetermined trajectory. The unit further includes means for acquiring images of the dental arch of a patient corresponding to the positions of the detector and of the source with respect to the dental arch. There is also provided means for reconstruction of a two portions of a panoramic image corresponding respectively to two disconnected portions of the dental arch, the reconstruction being performed from certain acquired images which each contain at least one piece of information concerning the two disconnected portions of the dental arch.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 30, 2015
    Assignee: Carestream Health, Inc.
    Inventors: Anna-Sesilia Vlachomitrou, Sylvie Bothorel, Jean-Marc Inglese
  • Publication number: 20150146841
    Abstract: A metrology device includes a light source and an image sensor. The light source is configured for providing an X-ray illuminating a wafer. The image sensor is configured for detecting a spatial domain pattern produced when the X-ray illuminating the wafer.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 28, 2015
    Applicant: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventors: Su-Horng LIN, Chi-Ming YANG
  • Patent number: 8965089
    Abstract: A method of analyzing a medical image, where the medical image comprises one or more than one region of interest, and where the method comprises a) providing the medical image comprising a set of actual image values; b) rescaling the actual image values to produce corresponding rescaled image values and to produce a rescaled image from the rescaled image values; c) deriving a histogram of the rescaled image values; d) using the histogram to derive an adaptive segmentation threshold; e) using the adaptive segmentation threshold to recursively split the rescaled image; f) terminating the recursive splitting of the sub(sub) images using one or more than one predetermined criteria; and g) identifying one sub(sub) image in the terminated Hierarchical Region Splitting Tree which comprises the region of interest.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: February 24, 2015
    Assignees: Loma Linda University, The Regents of the University of California
    Inventors: Nirmalya Ghosh, Stephen Ashwal, Andre Obenaus, Bir Bhanu
  • Patent number: 8917918
    Abstract: In a method processor and magnetic resonance (MR) system to generate MR slice exposures of an examination subject, measurement data for a stack of measurement slices through the examination subject are initially acquired using a series of slice measurement sequences. The series of slice measurement sequences is designed to allow a separation of a first material from a second material that has a defined chemical shift relative to said first material, and the position of a measurement slice with measurement data for the first material is spatially shifted relative to the position of a measurement slice with measurement data for the second material.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: December 23, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Vladimir Jellus, Mathias Nittka
  • Patent number: 8859264
    Abstract: A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: October 14, 2014
    Assignee: GSI Helmholtzzentrum fuer Schwerionenforschung GmbH
    Inventors: Christoph Bert, Eike Rietzel, Alexander Gemmel
  • Publication number: 20140299784
    Abstract: A radioactive substance detection device that detects a radioactive substance being present in a specified direction. A radiation detection element having a thickness that stops and detects a characteristic X-ray arriving from a radioactive substance being present in the specified direction that radiates both gamma rays and the characteristic X-rays, and allows the gamma ray arriving from the radioactive substance to pass through. A screening body having a thickness that screens out characteristic X-rays of radiation which arrives from directions other than the specified direction and allows gamma rays of radiation which arrives from directions other than the specified direction to pass through.
    Type: Application
    Filed: January 12, 2013
    Publication date: October 9, 2014
    Applicant: National Institute of Radiological Sciences
    Inventors: Shingo Kobayashi, Yukio Uchihori, Yoshiyuki Shirakawa
  • Patent number: 8837791
    Abstract: A method of locating anatomical features in a medical imaging dataset comprises obtaining a medical imaging measurement dataset that comprises image data for a subject body as a function of position; and performing a registration procedure that comprises:—providing a mapping between positions in the measurement dataset and positions in a reference dataset, wherein the reference dataset comprises reference image data for a reference body as a function of position, the reference dataset comprises at least one anatomical landmark, and the or each anatomical landmark is indicative of the position of a respective anatomical feature of the reference body; matching image data in the measurement dataset with image data for corresponding positions in the reference dataset, wherein the corresponding positions are determined according to the mapping; determining a measure of the match between the image data of the measurement dataset and the image data of the reference dataset; varying the mapping to improve the match b
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: September 16, 2014
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventors: Costas Plakas, Ian Poole
  • Patent number: 8750620
    Abstract: Described embodiments include a system, method, and program product. A described system includes a circuit that determines a substantial correspondence between (x) a perceivable feature included in a border region of a selected digital image and (y) a perceivable feature included in each other digital image of a plurality of digital images. A circuit gathers the determined substantial correspondences. A circuit generates data indicative of a border region-overlap status of the selected digital image. A circuit adds the data to an omitted-coverage list. A circuit iteratively designates a next digital image from the plurality of digital images as the selected digital image until each digital image has been designated. This circuit initiates processing of each of the iteratively designated next digital images. A circuit identifies a possible non-imaged portion of the region of interest. A circuit outputs informational data indicative of the possible non-imaged portion.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: June 10, 2014
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Erez Lieberman, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Patent number: 8731259
    Abstract: A method of matching medical images according to user-defined matches rules. In one embodiment, the matched medical images are displayed according user-defined display rules such that the matched medical images may be visually compared in manner that is suitable to the viewer's viewing preferences.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: May 20, 2014
    Assignee: DR Systems, Inc.
    Inventors: Murray A. Reicher, Evan K. Fram, Steven M. Greim, John J. Schumacher
  • Patent number: 8731261
    Abstract: A method of analyzing a medical image, where the medical image comprises one or more than one region of interest, and where the method comprises a) providing the medical image comprising a set of actual image values; b) rescaling the actual image values to produce corresponding rescaled image values and to produce a rescaled image from the rescaled image values; c) deriving a histogram of the rescaled image values; d) using the histogram to derive an adaptive segmentation threshold; e) using the adaptive segmentation threshold to recursively split the rescaled image; f) terminating the recursive splitting of the sub(sub) images using one or more than one predetermined criteria; and g) identifying one sub(sub) image in the terminated Hierarchical Region Splitting Tree which comprises the region of interest.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: May 20, 2014
    Assignee: Loma Linda University
    Inventors: Nirmalya Ghosh, Stephen Ashwal, Andre Obenaus, Bir Bhanu
  • Patent number: 8731642
    Abstract: A method for determining by an x-ray projection a position of a target radiopaque marker disposed on a catheter in a subject's body, comprising assigning a landmark in the body as a reference point compensated for periodic movements of the body, determining an auxiliary location relative to the reference point using at least one additional radiopaque marker disposed on the catheter and based on the auxiliary location determining the position of the target radiopaque marker with respect to the reference point.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: May 20, 2014
    Assignee: Paieon Inc.
    Inventors: Michael Zarkh, Rafael Shmuel Brada
  • Patent number: 8682045
    Abstract: A system, and computer implemented method are provided for interactively displaying three-dimensional structures. Three-dimensional volume data (34) is formed from a series of two-dimensional images (33) representing at least one physical property associated with the three-dimensional structure, such as a body organ having a lumen. A wire frame model of a selected region of interest is generated (38b). The wireframe model is then deformed or reshaped to more accurately represent the region of interest (40b). Vertices of the wire frame model may be grouped into regions having a characteristic indicating abnormal structure, such as a lesion. Finally, the deformed wire frame model may be rendered in an interactive three-dimensional display.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 25, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: David J. Vining, Gordon W. Hunt, David K. Ahn, David R. Stelts, Yaorong Ge, Paul F. Hemler, Tiffany W. Salido
  • Patent number: 8644615
    Abstract: Described embodiments include a system, method, and program product. A described system includes a circuit that determines a substantial correspondence between a human-perceivable feature included in a border region segment of a selected medical skin image and a human-perceivable feature included in each other medical skin image of a plurality of medical skin images. A circuit gathers the determined substantial correspondences. A circuit generates data indicative of a border region-overlap status of the selected medical skin image. A circuit adds the data to an omitted-coverage list. A circuit iteratively designates a next medical skin image as the selected digital image, and initiates a processing of each of the iteratively designated next medical skin images. A circuit identifies a possible non-imaged portion of the region of interest. A circuit outputs user-assistance information based on the identified possible non-imaged portion of the skin.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: February 4, 2014
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Erez Lieberman, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Patent number: 8634647
    Abstract: Described embodiments include a system, method, and computer program product. A described system includes a feature-detection circuit that extracts a perceivable feature included in each digital image of a plurality of digital images. Each digital image includes a respective portion of a region of interest of a surface. A feature-matching circuit determines a substantial correspondence between (x) a perceivable feature included in a border region segment of a selected digital image and (y) at least one perceivable feature included in each digital image of the plurality of digital images other than the selected digital image. A data collection circuit gathers the determined substantial correspondences for the perceivable feature included in the border region segment of the selected digital image. A reporting circuit outputs informational data indicative of a possible non-imaged portion of the region of interest of the surface.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: January 21, 2014
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Erez Lieberman, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Patent number: 8634648
    Abstract: Described embodiments include a system, method, and program product. A described system includes a circuit that extracts a human-perceivable feature included in each medical skin image of a plurality of medical skin images. Each medical skin image includes a respective portion of a region of interest of a surface of the skin of the individual human, and was acquired by a handheld device. A circuit determines a substantial correspondence between (x) a human-perceivable feature included in a border region segment of a selected medical skin image and (y) a human-perceivable feature included in each medical skin image of the plurality of medical skin images other than the selected medical skin image. A circuit gathers the determined substantial correspondences. A circuit outputs informational data indicative of a possible non-imaged portion of the region of interest of the skin of the individual human adjacent to the selected medical skin image.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: January 21, 2014
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Erez Lieberman, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Patent number: 8625868
    Abstract: According to one embodiment, a radiation diagnostic apparatus includes a photon-counting detector, a counting information storage unit, an image reconstituting unit, and a controlling unit. The detector performs counting on light derived from incident radiation. The counting information storage unit stores therein counting information based on the counting result of the detector. The image reconstituting unit reconstitutes a medical image by performing a back projection process on projection data that is generated by use of the counting information stored in the counting information storage unit. After the reconstitution of the medical image, the controlling unit performs control so that all or part of the counting information is maintained in the counting information storage unit.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: January 7, 2014
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventors: Takuzo Takayama, Manabu Teshigawara, Kenta Moriyasu
  • Patent number: 8532353
    Abstract: A computing system and method for generating, displaying and manipulating synthetic 2D and 3D brain tissue viability images and associated metrics from multiple perfusion maps derived from CT or other imaging system input image datasets. Stored linguistic tissue classification rules characterizing infarct, ischemic and/or normal or other tissue classes as a function of one or more perfusion parameters are used. The perfusion maps are normalized to normal brain tissue regions. Elements of the input image dataset are classified into one of the tissue classes as a function of the normalized perfusion maps and the classification rules. The classification includes ranking each of the plurality of tissue classes for elements of the input image dataset, and assigning one of the classes to elements of the dataset as a function of the ranks.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: September 10, 2013
    Assignee: Vital Images, Inc.
    Inventors: Pascal Salazar-Ferrer, Bennett W. Jackson, Stefan E. Atev
  • Patent number: 8498461
    Abstract: In a method to determine an MR system-dependent phase information of a phase value in an MR phase image data set, initial variances are associated with image points of a first phase image data set, and for an additional phase image data set, a phase value and a variance of the phase value for the image points of the additional phase image data set are estimated by a linear transformation of the first phase image data set. The additional image data set is calculated by weighted addition of the phase values of the first phase image data set with the estimated phase values, with the weighting of the two phase values taking place in the addition dependent on the variance belonging to the respective phase value.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: July 30, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventor: Patrick Gross
  • Patent number: 8497000
    Abstract: Disclosed is a method for modifying wettability of a surface of an inorganic material, the method comprising the steps of: preparing an inorganic material with a surface; and charging the surface of the inorganic material with positive surface charges obtained from photoelectron-emission by an X-ray irradiation to the surface of the inorganic material.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: July 30, 2013
    Assignee: Postech Academy-Industry Foundation
    Inventors: Yong Bum Kwon, Byung Mook Weon, Kyu Hwang Won, Jung Ho Je
  • Patent number: 8488854
    Abstract: A system and apparatus for classifying x-ray energy into discrete levels include an imaging system comprising an x-ray source, a detector, and a DAS having a discriminator assembly configured to count photon hits in the detector. A computer causes the discriminator assembly to count photon hits in the detector having an energy level greater than or equal to first and second threshold levels during an imaging scan, wherein the second threshold level is distinct from the first threshold level. The computer further modifies the counted photon hits having an energy level greater than or equal to the first threshold level based on the counted photon hits having an energy level greater than or equal to the second threshold level and reconstructs an image based on the modified photon hits and based on the counted photon hits having an energy level greater than or equal to a second threshold level.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: July 16, 2013
    Assignee: GE Medical Systems Israel, Ltd.
    Inventors: Jerome Stephen Arenson, Ofer Pinhasi, Daniel Rubin, Baruch Rosner, Lev Greenberg
  • Patent number: 8417005
    Abstract: A method for automatically segmenting a volume-of-interest representative of a subject's breast from a three-dimensional magnetic resonance image is provided. The three-dimensional image may include a plurality of spatially contiguous two-dimensional images. The image is converted to a monogenic signal, which is analyzed to determine locations in the image that correspond to maximal phase congruency in the monogenic signal. The orientation of each of these locations is determined and used along with the locations to estimate a boundary surface of the volume-of-interest. The estimated surface may be used to segment the image directly, or to generate a surface model, such as a statistical shape model, that is used to segment the image. This provided method is robust to segmenting the subject's breast, even at the chest-wall boundary in images with lower contrast-to-noise ratio between breast tissue and tissues in and around the chest wall.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: April 9, 2013
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Anne L Martel, Cristina Gallego
  • Patent number: 8326009
    Abstract: In a continuous mammography procedure, the breast of a subject is fixed in place in a retention device, and a first x-ray image is generated by irradiating the breast in the retention device. While the breast is still held in the retention device, the first x-ray image is evaluated to define a condition for generating a second x-ray image. The second x-ray image is then generated according to the defined condition, with the breast still in the same position in the retention device.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: December 4, 2012
    Assignee: Siemens Aktiengesellschaft
    Inventors: Wilhelm Hanke, Thomas Mertelmeier
  • Publication number: 20120259318
    Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
    Type: Application
    Filed: June 18, 2012
    Publication date: October 11, 2012
    Applicant: INTARCIA THERAPEUTICS, INC.
    Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
  • Patent number: 8116544
    Abstract: An apparatus is provided with: a bone region extracting section for extracting bone regions representing bones of a subject within a plurality of axial tomographic images obtained from a three dimensional image representing a portion of the subject from the vicinity of the upper end of the liver to the vicinity of the pubic symphysis; a bone boundary point detecting section for detecting a plurality of bone boundary points representing the boundaries between the detected bone regions and regions positioned toward the interiors of the bone regions within the plurality of axial tomographic images; and an abdominal cavity region extracting section for estimating curved surfaces within the three dimensional image that substantially contact the interiors of the plurality of bone boundary points detected in each of the plurality of axial tomographic images, and for extracting a region surrounded by the curved surfaces as a three dimensional abdominal cavity region.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: February 14, 2012
    Assignee: FUJIFILM Corporation
    Inventor: Jun Masumoto
  • Patent number: 8116849
    Abstract: A method is disclosed for achieving improved quality of monitoring and diagnosis for heart functions. Specifically, a method is disclosed for continuous temperature measurement and thermal characterization of patient heart tissue based on non-invasive thermal mapping technology. The method includes multi-dimensional cardiac tissue temperature scanning and tissue thermal pattern analysis with high precision, which can greatly improve the efficiency and lower the medical procedure risk for identifying myocardial ischemia (MI) disorders, predicting the MI occurrence, and mapping MI characteristics and impacting MI medical treatment, such as drug delivery and long term cardiac care. A system is also disclosed for use with the method.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: February 14, 2012
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hongxuan Zhang, Myrtis Randolph
  • Publication number: 20120033082
    Abstract: A system and method for detecting and monitoring one or more targets uses surveillance monitors that are selectively aligned in pre-determined directions to form an integrated field of view (IFOV). The IFOV or portions thereof may be illuminated using a scanning laser beam. Information provided by the surveillance monitors is selectively processed in an order determined based on a pre-determined target search and monitoring algorithm. Embodiments are directed to increasing efficiency of detecting or monitoring targets and, in particular, multiple moving targets.
    Type: Application
    Filed: August 6, 2010
    Publication date: February 9, 2012
    Applicant: D & S CONSULTANTS, INC.
    Inventor: Yei Wo
  • Patent number: 7983461
    Abstract: Provided is a method and an apparatus for extracting an edge of a distal radius metaphysis. The method includes: setting a region of interest including a distal radius in an X-ray image; setting a potential energy distribution of the region of interest by using a gradient of gray levels; setting a temporary edge adjacent to both sides of a distal radius metaphysis and a side of an epiphysis in the region of interest; and extracting a detailed edge of the distal radius metaphysis having minimum energy by adjusting the set temporary edge using a metropolis annealing technique.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: July 19, 2011
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sooyeol Lee, Jeong Won Lee, Seunghwan Kim, Seon Hee Park
  • Publication number: 20110129053
    Abstract: A system for determining ionization susceptibility including a sample, an x-ray generator configured to generate a pulsed x-ray beam, and focusing optics disposed between the sample and the x-ray generator, the focusing optics being configured to focus the pulsed x-ray beam into a spot on the sample.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 2, 2011
    Applicant: The Boeing Company
    Inventors: Mark Joseph Clemen, JR., Clarence Lavere Gordon, III, Jerry Lee Wert
  • Patent number: 7894577
    Abstract: A method and apparatus for downhole generation of non-radioactive, ionized radiation arranged so as to be able to generate reverberation, particularly X-ray and/or gamma radiation, from the surroundings of a borehole, wherein the method includes the steps of: exciting laser light in a multistage laser light booster by means of a pump-type laser light source so as to form a pulsed laser light, the incoming light energy being concentrated in restricted laser light pulses representing a higher amount of light energy than that of a continuous flux of laser light; forming a concentration of dissociated electrons in a vacuum chamber; focusing the pulsed laser light at a point in the concentration of dissociated electrons so as to form a field (wakefield) of pulsed electrons which, upon generation of Bremsstrahlung, emit ionized radiation to the surroundings, thereby forming a high-energy reverberation in the gamma and/or X-ray frequency range from the surroundings.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: February 22, 2011
    Assignee: Visuray AS
    Inventor: Phil Teague
  • Patent number: 7894652
    Abstract: A method for correcting PET emission data for prompt gamma emission background components present in non-pure positron-emitting isotopes uses a two component fit of modeled scatter and modeled prompt gamma emission in the area of scatter tails in a normalized emission sinogram. The method allows a PET scan using non-standard PET isotopes to be quantitative and thus more clinically useful.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: February 22, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Charles H. Hayden, Jr., Michael E. Casey, Charles C. Watson
  • Patent number: 7865006
    Abstract: A method for facilitating a reduction in image artifacts is provided. The method includes receiving data regarding a scan of an object, reconstructing a plurality of images using the received data to form a three-dimensional image space, determining an orientation for a maximum intensity pixel operation, locating the maximum intensity pixels within a plurality of ray paths in accordance with the determined orientation, and filtering around each maximum intensity pixel along each ray path.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: January 4, 2011
    Assignee: General Electric Company
    Inventors: Jiang Hsieh, Stanley Haim Fox
  • Patent number: 7840041
    Abstract: A converting device that carries out data conversion on medical image data expressing a state of one pixel of a medical image using effective bits, which are part of a plurality of bits for one pixel and expressing information other than the medical image using redundant bits, which are different part from that of the effective bits, the converting device includes an invalidating unit that invalidates data expressed by the redundant bits.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: November 23, 2010
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Masami Fujieda
  • Publication number: 20100290582
    Abstract: A first x-ray image of the circuit board that is equipped with components only on a first side with a first x-ray device (2) that produces transmission images and a second x-ray image of a circuit board that is equipped with components on both sides with a second x-ray device (4) that produces transmission images are recorded in an x-ray testing method for checking circuit boards that are equipped with components on two sides, in particular for checking soldered joints. A test x-ray image is then evaluated in a computer unit in which the second side that is equipped with components is displayed in enhanced form by forming a function from the pixel values of the first x-ray image and the corresponding pixel values of the second x-ray image.
    Type: Application
    Filed: November 13, 2006
    Publication date: November 18, 2010
    Applicant: MatriX Technologies GmbH
    Inventors: Eckhard Speschneider, Jan Rimbach, Martin Sokolowski, Timothy McGann
  • Publication number: 20100249545
    Abstract: Various embodiments for providing remote delivery and monitoring of health care are provided. In one embodiment, an apparatus for providing unmanned medical care in remote areas to a patient is provided. A container is adapted for transport using a standardized shipping mechanism. The container is adapted to provide remote delivery of health care. In an additional embodiment, a portable apparatus for dermatological monitoring is provided. An imaging device is integrated into a housing. The imaging device is adapted to obtain a digital, high-resolution image of a patient. In still another embodiment, a portable apparatus for orthopedic monitoring of a patient is provided. A housing is adapted for one of positioning adjacent to and positioning within an orthopedic cast. A diagnostic biomedical device integrated into the housing. The diagnostic biomedical device is adapted for obtaining an orthopedic image of a portion of the patient treated with the orthopedic cast.
    Type: Application
    Filed: March 24, 2009
    Publication date: September 30, 2010
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Michael Preston COPELAND, Mark Sean FLEMING, Christina Ann LARA, Calline Kris SANCHEZ
  • Patent number: 7773785
    Abstract: One embodiment discloses a computerized method of facilitating cardiac intervention, comprising inputting patient data, creating a computerized interactive model of a heart based on the patient data, wherein the model comprises features, simulating at least one proposed cardiac intervention treatment by adding or deleting features to the model, and determining the effects of the proposed cardiac simulation upon the entire model. Simulations may be repeated to allow the user to determine an optimal cardiac intervention. Additionally, a template may be created from the model to use as a guide during the cardiac intervention.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: August 10, 2010
    Assignee: Chase Medical, L.P.
    Inventors: Gregory Murphy, Mitta Suresh, Albert Michael Davis
  • Publication number: 20100111246
    Abstract: An x-ray beam processor and system that includes an x-ray beam generator for generating x-ray beams; a mirror shield for shielding the x-ray beams from select areas; a cylindrical waveguide for guiding x-ray beams traveling through the waveguide, which includes a plurality of entry ports and exit ports; a plurality of ring-shaped mirrors disposed adjacent to and generally parallel with the entry ports and the exit ports and sharing a common axis “X” with the waveguide; and mountings for mounting the mirrors to the waveguide.
    Type: Application
    Filed: October 30, 2009
    Publication date: May 6, 2010
    Inventor: Kenneth Oosting
  • Patent number: 7646901
    Abstract: One embodiment discloses a computerized method of facilitating cardiac intervention, comprising inputting patient data, creating a computerized interactive model of a heart based on the patient data, wherein the model comprises features, simulating at least one proposed cardiac intervention treatment by adding or deleting features to the model, and determining the effects of the proposed cardiac simulation upon the entire model. Simulations may be repeated to allow the user to determine an optimal cardiac intervention. Additionally, a template may be created from the model to use as a guide during the cardiac intervention.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: January 12, 2010
    Assignee: Chase Medical, L.P.
    Inventors: Gregory Murphy, Mitta Suresh, Albert Michael Davis
  • Patent number: 7636649
    Abstract: An optical metrology model for the structure is obtained. The optical metrology model comprising one or more profile parameters, one or more process parameters, and a dispersion. A dispersion function that relates the dispersion to at least one of the one or more process parameters is obtained. A simulated diffraction signal is generated using the optical metrology model and a value for the at least one of the process parameters and a value for the dispersion. The value for the dispersion is calculated using the value for the at least one of the process parameter and the dispersion function. A measured diffraction signal of the structure is obtained using an optical metrology tool. The measured diffraction signal is compared to the simulated diffraction signal to determine one or more profile parameters of the structure. The fabrication tool is controlled based on the determined one or more profile parameters of the structure.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: December 22, 2009
    Assignee: Tokyo Electron Limited
    Inventors: Shifang Li, Hanyou Chu, Manuel Madriaga
  • Publication number: 20090204032
    Abstract: A lithotripsy apparatus (2) comprises an X-ray system (3), with an isocentre (1) arranged in a mid-plane of the X-ray system (3), and a shockwave head (6) that can be oriented with respect to the isocentre (1) and is mounted on a support device (8). A particularly simple and stable mechanism for adjusting the shockwave head is obtained in which the support device (8) has a first adjustment unit (20) that can be moved linearly for horizontal adjustment of the shockwave head (6), a second adjustment unit (24) that can be moved linearly for adjusting the height of the shockwave head (6), and a rotary adjustment unit (22) for rotating the shockwave head (6).
    Type: Application
    Filed: February 1, 2007
    Publication date: August 13, 2009
    Inventors: Norbert Herrmann, Jochen Miguel Löseken
  • Publication number: 20090157317
    Abstract: An apparatus and a method for determining characteristics of earth formations traversed by a borehole that compensates the mudcake and standoff effects with fewer than usual detectors. The apparatus includes an radiation source effective to generate first and, spatially as well as temporally separate, second X-rays for irradiating earth formations from first and second entrance angles, one or more X-ray detectors capable of generating a first and a second signal indicative of the intensity of the first and second X-rays returned from earth formations to the detectors and a housing accommodating the radiation source and the detectors.
    Type: Application
    Filed: December 14, 2007
    Publication date: June 18, 2009
    Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventor: Charles R. Case
  • Publication number: 20090147907
    Abstract: An X-ray downhole imaging tool is provided and includes an X-ray tube capable of operating at least at 50 KeV and emitting at least one hundred micro-amperes of continuous electron current and a radiation detector axially displaced from the X-ray tube, at least partially shielded therefrom and radially directed. In certain embodiments, the radiation detector includes a microchannel plate and a resistive anode. In certain embodiments, a second detector which is axially directed is also provided.
    Type: Application
    Filed: December 5, 2007
    Publication date: June 11, 2009
    Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventor: Peter Wraight