Cell Analysis, Classification, Or Counting Patents (Class 382/133)
  • Patent number: 11113809
    Abstract: Systems and methods described herein relate, among other things, to unmixing more than three stains, while preserving the biological constraints of the biomarkers. Unlimited numbers of markers may be unmixed from a limited-channel image, such as an RGB image, without adding any mathematical complicity to the model. Known co-localization information of different biomarkers within the same tissue section enables defining fixed upper bounds for the number of stains at one pixel. A group sparsity model may be leveraged to explicitly model the fractions of stain contributions from the co-localized biomarkers into one group to yield a least squares solution within the group. A sparse solution may be obtained among the groups to ensure that only a small number of groups with a total number of stains being less than the upper bound are activated.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: September 7, 2021
    Assignee: VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Srinivas Chukka, Ting Chen
  • Patent number: 11107248
    Abstract: The present disclosure provides systems and methods for separating colors in an image by automatically selecting color reference vectors that take into consideration the effect of light scattering, and principally how the light scattering changes the proportions of RGB channel signals in detected light at varying stain concentrations.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: August 31, 2021
    Assignee: Ventana Medical Systems, Inc.
    Inventor: Yao Nie
  • Patent number: 11100348
    Abstract: A method of living body detection performed with a terminal device includes the following operations. A first image for a target object is obtained via a camera at a first focal length, and a second image for the target object is obtained via the camera at a second focal length. A difference image of the first image and the second image is determined. Whether the target object is a living body is determined according to the difference image.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: August 24, 2021
    Assignee: GUANGDONG OPPO MOBILE TELECOMMUNICATIONS CORP., LTD.
    Inventors: Haitao Zhou, Yibao Zhou, Cheng Tang, Xueyong Zhang
  • Patent number: 11100324
    Abstract: A method includes obtaining a set of image segment identigens for each image segment of an image to produce sets of image segment identigens. The sets of image segment identigens are possible interpretations of an image segment. The method further includes generating a set of relationships between image segments. The relationships provide a list of one or more ways in which the image segments are related. The method further includes processing different permutations of the sets of image segment identigens in accordance with the set of relationships to generate an entigen group. The entigen group represents a most likely interpretation of the image.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: August 24, 2021
    Assignee: entigenlogic LLC
    Inventors: Frank John Williams, David Ralph Lazzara, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Gary W. Grube
  • Patent number: 11093546
    Abstract: In one aspect, a computer implemented method for extracting information on actions or activities captured in digital data includes steps of: providing a first digital data set, extracting and characterizing first features from the first digital data set, creating first clusters from the extracted first features according to probability density functions and reference function distance calculations, providing a second digital data set, extracting and characterizing second features from the second digital data set, characterizing the extracted second features according to probability density functions and reference function distance calculations, and matching the second extracted features to a portion of the first extracted features clusters according to similarities in reference function distance calculations.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: August 17, 2021
    Assignee: The Procter & Gamble Company
    Inventor: Jose M Ortega
  • Patent number: 11080855
    Abstract: In some aspects, the described systems and methods provide for a method for predicting tissue characteristics for a pathology image. A statistical model trained on multiple annotated pathology images is used. Each of the training pathology images includes an annotation describing tissue characteristics for one or more portions of the image. The method includes accessing a pathology image for predicting tissue characteristics. A trained statistical model is retrieved from a storage device. A set of patches is defined from the pathology image. Each of the patches in the set includes a subset of pixels from the corresponding pathology image. The set of patches is processed using the trained statistical model to predict respective annotations for each patch in the set. The predicted annotations are stored on the storage device.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: August 3, 2021
    Assignee: Path AI, Inc.
    Inventors: Andrew H. Beck, Aditya Khosla
  • Patent number: 11074692
    Abstract: The present invention provides an image analysis method for generating data indicating a region of a cell nucleus in an image of a tissue or a cell. The image analysis method is a method for analyzing an image of a tissue or a cell using a deep learning algorithm of a neural network structure, and generates data indicating a region of a cell nucleus in an analysis target image by the deep learning algorithm by generating analysis data from the analysis target image including an analysis target tissue or cell, and inputting the analysis data in the deep learning algorithm.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: July 27, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Yosuke Sekiguchi, Kazumi Hakamada, Yuki Aihara, Kohei Yamada, Kanako Masumoto, Krupali Jain
  • Patent number: 11062470
    Abstract: A depth estimating apparatus operated by at least one processor includes: a database which stores a photographed first color image, a training thermal image geometrically aligned with the first color image, and a second color image simultaneously photographed with the first color image as a training image set; and a training apparatus which trains a neural network in an unsupervised manner to output a chromaticity image and a binocular disparity image from the training thermal image. The training apparatus generates an estimated first color image from the second color image, the chromaticity image, and the binocular disparity image, and trains the neural network to minimize a difference between the estimated first color image and the photographed first color image.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: July 13, 2021
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: In-So Kweon, Yukyung Choi, Nam Il Kim, Soonmin Hwang
  • Patent number: 11064029
    Abstract: A microscope device connected to a network includes a communication unit and a control unit. The communication unit receives master setting information from a data processor by communicating with the data processor over the network, and the master setting information includes multiple pieces of customizing setting information that correspond to multiple types of microscopy. The control unit registers or updates own-device-setting information of the microscope device in accordance with the master setting information received by the communication unit.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: July 13, 2021
    Assignee: OLYMPUS CORPORATION
    Inventors: Hiroshi Watanabe, Norikazu Urata
  • Patent number: 11054359
    Abstract: In view of such problems, the present invention provides a sample processing apparatus, a sample processing system, and a method of calculating measurement time, which allow an operator to efficiently capture images of cells. This invention relates to a sample processing apparatus 10 for measuring and analyzing a measurement sample 22. The sample processing apparatus 10 includes a light source 121 that irradiates light to the measurement sample 22, an imaging unit 154 that images light generated from the measurement sample 22 by irradiation with light, concentration information of cells included in the measurement sample 22 And a processing unit 11 that calculates a time required for cell imaging. The required time includes the time required for the processing of the image captured by the imaging unit 154 and the time required for the analysis of the image processed by the imaging unit 154.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: July 6, 2021
    Assignee: Sysmex Corporation
    Inventors: Shohei Matsumoto, Chikako Murata, Kenichiro Suzuki
  • Patent number: 11049011
    Abstract: Approaches for classifying training samples with minimal error in a neural network using a low complexity neural network classifier, are described. In one example, for the neural network, an upper bound on the Vapnik-Chervonenkis (VC) dimension is determined. Thereafter, an empirical error function corresponding to the neural network is determined. A modified error function based on the upper bound on the VC dimension and the empirical error function is generated, and used for training the neural network.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: June 29, 2021
    Assignee: Indian Institute of Technology Delhi
    Inventor: Jayadeva
  • Patent number: 11035845
    Abstract: An observation apparatus includes: an area calculation unit that calculates a colony area based on an image in which a cell colony is captured; a cell number calculation unit that calculates, based on the image, the number of cells included in a target colony of which an area is calculated by the area calculation unit; and a density calculation unit that calculates, based on the area of the target colony calculated by the area calculation unit and the number of the cells included in the target colony calculated by the cell number calculation unit, a density of the cells included in the target colony.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: June 15, 2021
    Assignee: NIKON CORPORATION
    Inventors: Yasujiro Kiyota, Hiroaki Kii
  • Patent number: 11037680
    Abstract: A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry obtains data on medical actions and data on differences between planned medical actions or achievement objectives of treatment and results thereof. The processing circuitry extracts relevant factors associated with the differences based on the data on the medical actions and the data on the differences. The processing circuitry the relevant factors by allocating elements included in classification criteria to the relevant factors. The processing circuitry displays the relevant factors on a display for each of the classification criteria.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: June 15, 2021
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Yusuke Kano, Kazumasa Noro, Longxun Piao
  • Patent number: 11030758
    Abstract: An automated tissue section slicing, staining, and imaging system efficiently registers full-resolution tissue section images by applying scaled transformation matrices computed to register downsampled tissue section images to the full-resolution tissue section images.
    Type: Grant
    Filed: May 18, 2019
    Date of Patent: June 8, 2021
    Assignee: Strateos, Inc.
    Inventor: Christopher Rhodes
  • Patent number: 11023705
    Abstract: The present application relates to a method for the cytometric analysis of multiple cell samples by a microscope for examining multiple cell samples under a microscope, wherein the microscope can be or is operated, selectively and/or alternatingly, in a transmission mode and/or in a fluorescence mode, and wherein at least one cell sample has at least one fluorescence marker. The method includes; moving the cell samples continuously in one plane relative to an optical system of the microscope having at least one microscope camera, wherein, during the movement of the cell samples, at least one or more images of a sub-region of the cell samples are recorded in the transmission mode or in the fluorescence mode and at least one or more images of the same sub-region of the cell samples are recorded in the fluorescence mode by the at least one microscope camera.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: June 1, 2021
    Assignee: OLYMPUS SOFT IMAGING SOLUTIONS GMBH
    Inventors: Mike Woerdemann, Stefan Diepenbrock, Sascha Hoefling, Daniel Krueger
  • Patent number: 11023562
    Abstract: A non-transitory computer-readable recording medium stores therein an analysis program that causes a computer to execute a process including: dividing a Betti number sequence into a plurality of Betti number sequences, the Betti number sequence being included in a result of a persistent homology process performed on time series data, the plurality of Betti number sequences corresponding to different dimension of the Betti number sequence; and performing an analysis on each of the plurality of Betti number sequences.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: June 1, 2021
    Assignee: FUJITSU LIMITED
    Inventors: Ken Kobayashi, Yuhei Umeda, Masaru Todoriki, Hiroya Inakoshi
  • Patent number: 11022605
    Abstract: Disclosed herein are cell culture analog devices, systems and methods for applying stimuli to components containing different cell types and recording the cell responses before, during, and after a stimulus (for example, a drug, metabolite, toxin, or electrical stimulus) is introduced. Responses can be stored to a database and compared to previous results. By analyzing how each cell type responds to various stimulation parameters, for example, by using multivariate analyses, cell signaling pathway information can be determined or new pathways can be discovered. In some implementations, an individual component interfaces with a specific cell type. This facilitates readout of the cell response to the stimulation. Various components can also interface with each other, such that the behavior of one cell type can affect a cell type in another component. Once assembled, the system is plugged into readout electronics and a programmable electrical stimulator.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 1, 2021
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Lee Kumanchik, Navaneetha Santhanam
  • Patent number: 11017533
    Abstract: The system is configured to receive at least one digital image of a tissue sample of a patient; analyze the at least one received image for identifying tumor cells in a region of the at least one received image; analyze the at least one received image for identifying FAP+ areas in the region, each FAP+ area being a pixel blob representing one or more cells express the fibroblast activation protein—“FAP”; analyze the at least one received image for identifying distances between the identified tumor cells and their respective nearest FAP+ area; computing a proximity measure as a function of the identified distances; process the proximity measure by a classifier for generating a classification result, the classification result indicating if the tumor of the patient can be treated by a drug or drug-component that binds to FAP; and output the classification result.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: May 25, 2021
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Fabien Gaire, Oliver Grimm, Hadassah Sumum Sade, Suzana Vega Harring
  • Patent number: 11013494
    Abstract: An ultrasound imaging apparatus includes a processor configured to set an internal orifice of an uterus (IOS) point indicating the IOS of a cervix and an external orifice of an uterus (EOS) point indicating the EOS of the cervix, from a cervix line indicating a cervical canal, set a region of interest (ROI) of the IOS and a ROI of the EOS based on the IOS point and the EOS point, and calculate degrees of elasticity in the ROI of the IOS and the ROI of the EOS, and a display configured to display information indicating the degrees of elasticity in the ROI of the IOS and the ROI of the EOS.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: May 25, 2021
    Assignee: SAMSUNG MEDISON CO., LTD.
    Inventors: Jung-eun Lee, Dong-kuk Shin, Dal-kwon Koh, Gil-ju Jin, Soo-young Oh, Han-sung Hwang
  • Patent number: 11004199
    Abstract: Systems and methods for automated stereology are provided. A method can include providing an imager for capturing a Z-stack of images of a three-dimensional (3D) object; constructing extended depth of field (EDF) images from the Z-stack of images; performing a segmentation method on the EDF images including estimating a Gaussian Mixture Model (GMM), performing morphological operations, performing watershed segmentation, constructing Voronoi diagrams and performing boundary smoothing; and determining one or more stereology parameters such as number of cells in a region.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: May 11, 2021
    Assignees: UNIVERSITY OF SOUTH FLORIDA, STEREOLOGY RESOURCE CENTER, INC.
    Inventors: Peter Randolph Mouton, Hady Ahmady Phoulady, Dmitry Goldgof, Lawrence O. Hall
  • Patent number: 10990798
    Abstract: An analysis device includes: a cell image acquisition unit that acquires a plurality of cell images in which a stimulated cell has been captured; a feature value calculation unit that calculates a feature value for each of first and second constituent elements constituting the cell, from the cell images acquired by the cell image acquisition unit; a correlation calculation unit that calculates correlations between first feature values and between second feature values in the first and second constituent elements calculated by the feature value calculation unit; a correlation extraction unit that extracts the correlation between the first feature values by selecting the first feature values with respect to the correlations between the feature values in the first and second constituent elements calculated by the correlation calculation unit; and a display unit that displays the correlation between the first feature values extracted by the correlation extraction unit.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: April 27, 2021
    Assignees: THE UNIVERSITY OF TOKYO, NIKON CORPORATION
    Inventors: Masayuki Murata, Fumi Kano, Yoshiyuki Noguchi, Hirotada Watanabe, Nobuhiko Maiya, Shinichi Furuta, Takuro Saigo, Mamiko Masutani, Masafumi Yamashita, Shoko Yamasaki
  • Patent number: 10989908
    Abstract: A method and a corresponding calibration system for calibrating a microscope system involve a recording of an overview image of a sample stage of the microscope system and an identification of a calibration sample in the recorded overview image. Moreover, The calibration sample in the recorded overview image is classified into one of a plurality of calibration sample classes using a classification system, which was trained using training data, in order to form a model so that the classification system is adapted for classifying unknown input data into prediction classes. A of a calibration workflow for calibrating the microscope system is selected based on the classified calibration sample class. The selection is performed using a workflow indicator value serving as an input value for a workflow selection system.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: April 27, 2021
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Manuel Amthor, Daniel Haase, Thomas Ohrt
  • Patent number: 10980404
    Abstract: The invention relates to a method for producing an image numerical classifier, to automatically determine the visualization quality of endoscopy videocapsule images of segments of the digestive tract, comprising a step of acquiring a video in the digestive tract by a videocapsule; a step of extracting images from the video; a so-called “ground truth” step of clinically evaluating the visualization quality of the images based on medical criteria, a step of selecting an initial set of “adequate” visualization images and “inadequate” visualization images, a step of calculating at least one numerical parameter relating to at least one of the medical criteria, a statistical machine learning step to produce the numerical classifier.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: April 20, 2021
    Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, SORBONNE UNIVERSITÉ, ÉCOLE NATIONALE SUPÉRIEURE DE L'ÉLECTRONIQUE ET DE SES APPLICATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CY CERGY PARIS UNIVERSITÉ
    Inventors: Xavier Dray, Aymeric Histace
  • Patent number: 10957523
    Abstract: A method for analyzing a multidimensional data set includes generating a multidimensional mass spectrometry data set from a sample; and generating an matrix representing the multidimensional mass spectrometry data set such that a first dimension and a second dimension of the multidimensional mass spectrometry data set correspond to a matrix cell location, and an ion intensity corresponds to a matrix cell value; and determining a class of the matrix from a plurality of matrix classes using a trained neural network matrix classifier.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: March 23, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventors: Michael J. Athanas, Hossein Arjomand
  • Patent number: 10942965
    Abstract: A pathological image and a primary diagnosis result are obtained from a first terminal via a network, the first terminal being of a first user, the primary diagnosis result being a diagnosis result about the pathological image by the first user. The obtained pathological image and the primary diagnosis result are provided to at least one second terminal via the network, the one second terminal being of at least one second user. A browsing history and an opinion of the second user are obtained from the second terminal via the network, the browsing history at least including information on a displayed area in the pathological image, the opinion of the second user being about the primary diagnosis result based on observation of the pathological image by the second user. The obtained browsing history is estimated, and a reliability score of the obtained opinion is generated.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: March 9, 2021
    Assignee: SONY CORPORATION
    Inventors: Shigeatsu Yoshioka, Masahiro Takahashi, Hiroshi Yamaguchi, Masayuki Morota
  • Patent number: 10937159
    Abstract: Embodiments discussed herein relate to accessing a digitized image associated with a patient of tissue demonstrating breast cancer pathology; segmenting a tumor region represented in the digitized image; segmenting collagen fibers represented in the tumor region; computing collagen vectors based on the segmented collagen fibers; generating an orientation co-occurrence matrix based on the collagen vectors; computing a collagen fiber orientation disorder feature based on the co-occurrence matrix; upon determining that the collagen fiber orientation feature exceeds a threshold value: generating a prognosis of the region of tissue as unlikely to experience breast cancer recurrence; upon determining that the collagen fiber orientation feature is less than or equal to the threshold value: generating a prognosis of the region of tissue as likely to experience breast cancer recurrence; classifying the patient as high-risk of recurrence or low-risk of recurrence based, at least in part, on the prognosis; and displayin
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: March 2, 2021
    Assignee: Case Western Reserve University
    Inventors: Anant Madabhushi, Haojia Li
  • Patent number: 10937226
    Abstract: A medical image processing apparatus comprises processing circuitry configured to acquire a first blood vessel image based on X-rays that are irradiated from a first direction and a second blood vessel image based on X-rays that are irradiated from a second direction; determine a corresponding point on the second blood vessel image, which is a point corresponding to a subject point on the first blood vessel image, by using an epipolar line corresponding to the subject point and blood-flow information based on a change of a density of a contrast agent over time at the subject point; and reconstruct a three-dimensional blood vessel image by using information about the subject point and the corresponding point.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: March 2, 2021
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventor: Satoru Ohishi
  • Patent number: 10929945
    Abstract: The present disclosure provides image capture devices and associated methods that feature intelligent use of hardware-generated statistics. An example image capture device can include an imaging hardware pipeline that generates frames of imagery. The imaging hardware pipeline can generate one or more hardware-generated statistics based at least in part on, for example, the raw image data captured by the image sensor or intermediate image data within the pipeline. The image capture device can analyze the hardware-generated statistics to determine one or more metrics for the raw image data or the image. The image capture device can determine a downstream operation of the image capture device relative to the image based at least in part on the metrics determined from the hardware generated statistics.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: February 23, 2021
    Assignee: Google LLC
    Inventors: Suk Hwan Lim, Huizhong Chen, David Chen, Hsin-I Liu
  • Patent number: 10921575
    Abstract: A method and associated method and computer program product for acquiring focused images of a specimen on a slide, by determining optimal scanning trajectories. The method includes capturing a relatively low magnification image of the slide to locate the specimen, forming a grid that includes an arrangement of grid points, overlaying at least part of the grid over a field of view that covers at least part of the specimen, capturing a relatively high magnification Z-stack of images of the specimen within the field of view, determining a best focus for each grid point within said at least part of the grid to form a resulting grid of three dimensional points, and based on the resulting grid, determining one or more three dimensional scanning trajectories.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: February 16, 2021
    Assignee: VENTANA MEDICAL SYSTEMS, INC.
    Inventors: Joerg Bredno, Jim Martin, Anindya Sarkar
  • Patent number: 10920262
    Abstract: [Problem] To provide a highly accurate cell measurement method. [Solution] A cell measurement method comprising: a step of staining target cells with a dye; an image obtaining step for obtaining an image of the target cells; a discrimination step for discriminating the target cells from contaminating cells by applying multi-stage binarization processing to the image; a step of eliminating noises due to the contaminating cells from the image based on the result of the discrimination step; and a step of evaluating an amount of target cells by integrating an index value of cell amount in the image from which the contaminating cells have been eliminated.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: February 16, 2021
    Assignee: KURASHIKI BOSEKI KABUSHIKI KAISHA
    Inventors: Yuko Nanjo, Hiroyuki Asano, Isao Miyagawa, Yoshio Takada
  • Patent number: 10915729
    Abstract: The ability to automate the processes of specimen collection, image acquisition, data pre-processing, computation of derived biomarkers, modeling, classification and analysis can significantly impact clinical decision-making and fundamental investigation of cell deformation. This disclosure combine 3D cell nuclear shape modeling by robust smooth surface reconstruction and extraction of shape morphometry measure into a highly parallel pipeline workflow protocol for end-to-end morphological analysis of thousands of nuclei and nucleoli in 3D. This approach allows efficient and informative evaluation of cell shapes in the imaging data and represents a reproducible technique that can be validated, modified, and repurposed by the biomedical community. This facilitates result reproducibility, collaborative method validation, and broad knowledge dissemination.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: February 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ivaylo Dinov, Brian D. Athey, David S. Dilworth, Ari Allyn-Feuer, Alexandr Kalinin, Alex S. Ade
  • Patent number: 10902295
    Abstract: Techniques for using image dataset transformations to verify the quality of a computer vision system are disclosed. In some example embodiments, a computer-implemented method comprises: accessing a database to obtain a reference image; generating a plurality of new images based on the reference image using a plurality of transformations, each one of the plurality of transformations being configured to change a corresponding visual property of the reference image; feeding the plurality of new images into an image classifier to generate a corresponding classification result for each one of the plurality of new images; determining that the image classifier does not satisfy one or more accuracy criteria based on the generated classification results for the plurality of new images; and based on the determining that the image classifier does not satisfy the one or more accuracy criteria, selectively performing a function.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: January 26, 2021
    Assignee: SAP SE
    Inventor: Juliy Broyda
  • Patent number: 10891377
    Abstract: A computer implemented method to identify a derivative of one or more malicious software components in a computer system including: evaluating a measure of a correlation fractal dimension (CFD) for at least a portion of a monitored software component in the computer system, the CFD including a plurality of CFD values varying with a resolution of fractal dimension; and comparing the plurality of CFD values with a reference measure of CFD for each of the malicious software components, each reference measure of CFD including a plurality of CFD values varying with a resolution of fractal dimension, so as to identify one or more of the plurality of malicious software components from which the monitored software component is derived.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: January 12, 2021
    Assignee: British Telecommunications Public Limited Company
    Inventors: Fadi El-Moussa, George Kallos
  • Patent number: 10877255
    Abstract: An instrument for imaging a specimen or a portion of a specimen is configured to capture multiple image frames of the portion of the specimen being scanned using Moving Specimen Image Average (MSIA) to create one or more image strips. The instrument is configured to use an active area of a two dimensional sensor array that covers substantially all of the width of the sensor array but less than a length. The one or more image strips are created from the multiple image frames as each of the multiple image frames is captured. Preferably, the instrument is configured to remove blurring, caused by distortion of the optics, by software or by warping a grid of the two dimensional detector array, including TDI array.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: December 29, 2020
    Assignee: Huron Technologies International Inc.
    Inventor: Arthur Edward Dixon
  • Patent number: 10880457
    Abstract: There is provided an image processing apparatus. A setting unit sets a first processing region in a part of a captured range. A selection unit selects a plurality of tracking target points in a first captured image of a plurality of captured images. A detection unit detects a motion vector of each tracking target point between the first captured image and a second captured image subsequently captured after the first captured image. A determination unit determines whether a moving object has appeared in the first processing region. A control unit performs control to iterate a first process set until it is determined that the moving object has appeared in the first processing region, and to iterate a second process set after it is determined that the moving object has appeared in the first processing region.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 29, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Tomotaka Uekusa, Hiroyuki Yaguchi
  • Patent number: 10865376
    Abstract: A method detects the presence or absence of at least one first inhibition zone having a culture of biological particles on a culture medium in the presence of a chemical agent. The method of detection has a first step of seeding the culture medium with the biological particles, a second step in which the culture medium receives the chemical agent, a third step of incubation of the culture medium, and a fourth step of measurement of the first inhibition zone of the culture medium, which includes a first phase of taking an image of the first inhibition zone by ombroscopy.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: December 15, 2020
    Assignee: BIOMERIEUX
    Inventors: Laurent Drazek, Frédéric Pinston
  • Patent number: 10867208
    Abstract: A high content analysis computing system, computer program product and method provides receiving two or more sets of microscopic images of respective sites of selected biological cell assay. Each set of microscopic images comprises one or more images having an aggregate field of view sufficient to encompass all of the cells within the respective site and a resolution sufficient to image cellular bodies within each of encompassed cells. For each set of microscopic images, a library of algorithms is executed that evaluate image features for each cell in each site producing a quantified feature measurement for each cell. Quantified feature measurements are compared for each one of the two or more sets of microscopic images. A subset of the library of algorithms is identified that discriminate at least two of the two sets or more microscopic images and deployed as a computer program product for evaluating additional biological cell assays.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: December 15, 2020
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Thomas Lamkin, Patrick McLendon, Daniel Cowan, Robert Trevino
  • Patent number: 10860835
    Abstract: Provided is an image processing device including: a memory; and a processor comprising hardware, the processor configured to: calculate a feature value; detect, as peak positions, pixel positions the feature value of which are greater than a prescribed feature value threshold value; record the detected peak positions; form, one at a time for the detected peak positions, a cell region; identify a center position of the formed cell region; determine, by using at least one of the peak position, a morphology of the cell region, and the center position of the cell region, a proximity state between the currently formed cell region and a previously formed cell region; and correct, when it is determined that the proximity state is satisfied, at least one of the currently formed cell region and the previously formed cell region.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: December 8, 2020
    Assignee: OLYMPUS CORPORATION
    Inventor: Hideya Aragaki
  • Patent number: 10846849
    Abstract: The present invention provides a method and an apparatus for analyzing a cell state, cell death in particular, in an interior of a spheroid non-invasively and quantitatively when the spheroid is cultured. More specifically, the present invention provides a method and an apparatus for analyzing a cell state by implementing optical imaging of a spheroid by using an optical instrument characterized by a high resolution and analyzing the internal structure of the spheroid.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: November 24, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Naoko Senda, Toshinari Sakurai
  • Patent number: 10845357
    Abstract: A fixed region at an outer periphery or an inner periphery of a sample that has a three-dimensional structure is selectively analyzed with accuracy. Provided is an observation system including a CPU that recognizes the 3D shape of an observation target, such as a spheroid, from a 3D image of cells, that sets a 3D mask of which the radial distance from a circumscribed surface of the recognized 3D shape is fixed over the entire region of the circumscribed surface and of which the shape is similar to the circumscribed surface, and that identifies a cell contained inside the set 3D mask.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: November 24, 2020
    Assignee: OLYMPUS CORPORATION
    Inventor: Yusuke Yamashita
  • Patent number: 10839266
    Abstract: Various systems and methods for implementing distributed object detection processing are described herein. An object detection system includes a plurality of computer vision accelerators to process a respective plurality of portions of an input image and produce a list of detected objects in the respective plurality of portions of the input image; and a processor subsystem to: combine the list of detected objects from each of the plurality of computer vision accelerators, to produce a combined list of detected objects; sort the combined list of detected objects; and remove duplicate entries in the combined list of detected objects to produce an output list of detected objects.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 17, 2020
    Assignee: Intel Corporation
    Inventors: Maciej Adam Kaminski, Amit Aneja, Robert Mahieu, Takeshi Kevin Yamane Musgrave
  • Patent number: 10839529
    Abstract: An image processing apparatus including an information acquisition unit that acquires information regarding a camera, an estimation unit that estimates an object of interest during shooting, in an image captured by the camera, based on the information regarding the camera, an area dividing unit that divides the image into a plurality of divided areas, using each of a plurality of types of dividing methods, and a motion vector detection unit that detects a motion vector in the plurality of divided areas regarding each of the plurality of types of dividing methods. The area dividing unit changes at least one of a size of a divided area and a number of division in each of the plurality of types of dividing methods for dividing the image, according to an object of interest estimated by the estimation unit.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: November 17, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Yu Narita
  • Patent number: 10832403
    Abstract: The described implementations relate to systems, methods, and apparatuses for generating regions of interest (214) from imaging data (212). Specifically, the regions of interest are generated for tracking treatment efficacy in a more consistent and repeatable manner. The regions of interest can be generated from contrast medium and non-contrast medium enhanced scans (102) of a patient. Voxel data derived from the scans can be collected and distributed according to respective intensity values in order to identify mode voxels (116, 118, 120) for particular ranges (128) of intensities. Regions of interest (110, 112, 114) can then be generated for each identified mode voxel, and standard deviations for the regions of interest can be determined. One or more thresholds can be derived from the determined standard deviations in order to further filter the intensity values and identify filtered groups of voxels to be the resulting regions of interest.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: November 10, 2020
    Assignees: KONINKLIJKE PHILIPS N.V., YALE UNIVERSITY
    Inventors: Johanna Van Breugel, Aaron Abajian, John Treilhard, Susanne Smolka, Julius Chapiro, James Duncan, MingDe Lin
  • Patent number: 10824906
    Abstract: An image processing device includes: a feature detection image generating unit that generates multiple feature detection images corresponding to multiple classes by applying a convolutional neural network having the classes learned previously to an input image; a post-processing unit that generates a measurement result by performing a post-process on at least some feature detection images of the multiple feature detection images on the basis of a setting parameter; and a user interface unit that receives an input of the setting parameter while presenting a user at least one of at least some of the feature detection images which are generated by the feature detection image generating unit and the measurement result which is generated by causing the post-processing unit to perform the post-process using at least some of the feature detection images which are generated by the feature detection image generating unit.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: November 3, 2020
    Assignee: OMRON Corporation
    Inventor: Yasuyuki Ikeda
  • Patent number: 10816475
    Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: October 27, 2020
    Assignee: Labrador Diagnostics LLC
    Inventors: Chinmay Pangarkar, Karan Mohan
  • Patent number: 10810407
    Abstract: A specific region such as a continuous epithelial structure is automatically detected in a cell aggregate. A region detecting method includes an input step (S01) of inputting an image obtained by imaging a cell aggregate, an outline detecting step (S02) of detecting an outline of the cell aggregate together with an order along the outline from the input image, a region detecting step (S03) of detecting a specific region included in the cell aggregate based on the detected outline and order, and an output step (S04) of outputting information indicating the detected region.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: October 20, 2020
    Assignees: RIKEN, Sumitomo Dainippon Pharma Co., Ltd., Sumitomo Chemical Company, Limited
    Inventors: Satoru Okuda, Mototsugu Eiraku, Atsushi Kuwahara
  • Patent number: 10809202
    Abstract: A process and an apparatus for measuring an amount of dissolved air which may be dispersed or entrained in liquids.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: October 20, 2020
    Inventor: Ricardo J. Hein
  • Patent number: 10809516
    Abstract: A method and system for mapping fluid objects on a substrate using a microscope inspection system that includes a light source, imaging device, stage for moving a substrate disposed on the stage, and a control module. A computer analysis system includes an object identification module that identifies for each of the objects on the substrate, an object position on the substrate including a set of X, Y, and ? coordinates using algorithms, networks, machines and systems including artificial intelligence and image processing algorithms. At least one of the objects is fluid and has shifted from a prior position or deformed from a prior size.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: October 20, 2020
    Assignee: Nanotronics Imaging, Inc.
    Inventors: Matthew C. Putman, John B. Putman, John Cruickshank, Julie Orlando, Adele Frankel, Brandon Scott
  • Patent number: 10802264
    Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 13, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Zuo Cheng Shen, Daniel Y. Chu, Nicholas Doe, Emmanuel Quiroz, Amber Iraeta
  • Patent number: 10792004
    Abstract: Systems (100) and methods (200, 1600) for generating a medical and/or dental diagnosis. The methods comprise: obtaining a true color image of a select part of a subject's body; converting the true color image to a grayscale intensity image; generating a histogram equalized image by adjusting the grayscale intensity image's contrast; processing the histogram equalized image to generate first information useful for generating the medical and/or dental diagnosis, the first information comprising at least one of (a) a ratio of a disease region's pixel mean intensity value and a normal region's mean pixel intensity value and (b) an indicator indicating whether a periodontal ligament space has widened or broken; and generating the medical and/or dental diagnosis based at least on the first information.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: October 6, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Jay Sureshbhal Patel