Blood Cells Patents (Class 382/134)
  • Patent number: 10275901
    Abstract: Embodiments of the present invention seek to provide an accurate way to measure the length of a fish. Some embodiments of the present invention propose utilizing a known length of a marker within a camera view or picture to determine the length of the fish also shown in the same camera view or picture. This determination could be performed in real-time or later remotely. Further, the measurement of the length of the fish is reliable because it is not dependent on a zoom value or angle of the camera and there is no required measurement device. Further, the technique is easy to use and can be performed with a camera phone or tablet.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: April 30, 2019
    Assignee: NAVICO HOLDING AS
    Inventor: Paul Butterworth
  • Patent number: 10203275
    Abstract: A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: February 12, 2019
    Assignee: Abbott Point of Care, Inc.
    Inventors: David Herzog, Zhizhou Wang, Stephen C. Wardlaw, Min Xie
  • Patent number: 10191053
    Abstract: The disclosure concerns a method for measuring and reporting vascularity in a biological tissue sample. The method generally includes: within a digital image of a tissue section, (i) identifying endothelial cells, lymphatic cells, or a combination thereof; (ii) mapping one or more proximity regions, each of the proximity regions defining an area between detected vessels and a first distance outwardly therefrom; and (iii) calculating one or more of: a vessel proximity score or a hypoxia score, wherein the vessel proximity score relates a composition of objects within the proximity regions, and wherein the hypoxia score relates a composition of tissue within or outside of the proximity regions, respectively.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: January 29, 2019
    Assignee: Flagship Biosciences, Inc.
    Inventor: Steven J. Potts
  • Patent number: 10080528
    Abstract: This document describes optical central venous pressure measurement. To determine the central venous pressure (CVP) of a person optically, video of a right side of the person's neck is captured. By way of example, a medical professional records a video of the right side of the person's neck using a smartphone. The right side of the person's neck is captured because it is where the person's external and internal jugular veins are located and pulsatile motions that are usable to measure CVP occur in those veins. The video is then processed according to video motion amplification techniques to generate a reconstructed video of the right side of the person's neck. In the reconstructed video, the pulsatile motion of the person's venous system that occurs at the right side of their neck is visually amplified. Using the reconstructed video, measurements are made of a distance between a peak of the visually-amplified pulsatile motion and an anatomical feature of the person.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: September 25, 2018
    Assignee: Google LLC
    Inventors: Brian Derek DeBusschere, James Moad Reid, Jeffrey L. Rogers
  • Patent number: 10055665
    Abstract: In imaging analysis of a living body, a Region Of Interest (ROI) is set on the basis of the state of radiopharmaceutical accumulation. An example for setting an ROI includes: performing first transformation for anatomically standardizing, with the use of a positive template, a nuclear medicine image acquired by applying a radiopharmaceutical to a subject; performing second transformation for anatomically standardizing, with the use of a negative template, the nuclear medicine image; calculating a degree of similarity between a first anatomical standardization image acquired by the first transformation and the positive template; calculating a degree of similarity between a second anatomical standardization image acquired by the second transformation and the negative template; and applying, to an ROI template, inverse transformation of the first transformation or the second transformation, whichever has the higher of the calculated degrees of similarity, in order to set the ROI.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 21, 2018
    Assignees: Nihon Medi-Physics Co., Ltd., Foundation for Biomedical Research and Innovation at Kobe
    Inventors: Go Akamatsu, Michio Senda, Yasuhiko Ikari, Shuya Miki
  • Patent number: 10043267
    Abstract: A method and apparatus is provided for medical image processing. The processing of the medical image extracting a living valve image by analyzing a 3D image of an anatomical organ of a subject, specifying a distribution of an amount of calcium in the living valve image from CT pixel values in the living valve image, and specifying a distribution of difficulty levels of implanting an artificial valve to the anatomical organ based on a comparison between the amount of calcium and a predetermined value.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: August 7, 2018
    Assignee: Toshiba Medical Systems Corporation
    Inventors: Kyohei Yamamori, Satoshi Wakai, Masahiro Ozaki
  • Patent number: 9934579
    Abstract: The present invention relates to an ultrasound imaging system (10) for inspecting an object (97) in a volume (40). The ultrasound imaging system comprises an image processor (36) configured to conduct a segmentation (80) of the object (97) simultaneously out of three-dimensional ultrasound mage data (62) and contrast-enhanced three-dimensional ultrasound image data (60). In particular, this may be done by minimizing an energy tem taking into account both the normal three-dimensional ultrasound image data and the contrast-enhanced three-dimensional image data. By this, the normal three-dimensional ultrasound image data and the contrast-enhanced three-dimensional image data may even be registered during segmentation. Hence, this invention allows a more precise quantification of one organ in two different modalities as well as the registration of two images for simultaneous visualization.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: April 3, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Raphael Manua Michel Prevost, Roberto Jose Ardon, Benoit Jean-Dominique Bertrand Maurice Mory
  • Patent number: 9858662
    Abstract: A device comprises: a nucleus-candidate-region extracting section that extracts, from a captured image obtained by image-capturing a sample piece including a target cell having a nucleus, a nucleus candidate region corresponding to the nucleus; a basic-probability-information acquiring section that acquires, for each of a plurality of determination subject regions determined on the basis of the nucleus candidate region extracted by the nucleus-candidate-region extracting section, basic probability information indicating probability that an image in the determination subject region is an image of the target cell, on the basis of a feature amount of the image of the determination subject region; and a probability-information calculating section that calculates probability information indicating probability that an image in a display subject region corresponding to the nucleus candidate region is the image of the target cell, on the basis of the basic probability information acquired for each of the plurality of
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: January 2, 2018
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Ryota Ozaki, Noriji Kato, Hideto Oda, Yukio Kumazawa
  • Patent number: 9684958
    Abstract: An image processing device 20 acquires captured images obtained by imaging a sample including a target cell, performs machine learning based on a first image feature quantity, sets a plurality of object regions for detecting the target cell in the captured images, and displays the plurality of object regions in an order determined based on the first image feature quantity of each of the plurality of object regions. The image processing device 20 calculates a second image feature quantity in each of the plurality of object regions, sorts the plurality of displayed object regions in an order of the second image feature quantity similar to the second image feature quantity of a reference object region selected from among the plurality of object regions, and displays the plurality of object regions.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: June 20, 2017
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Ryoko Usuba, Noriji Kato, Ryota Ozaki, Yukio Kumazawa
  • Patent number: 9645154
    Abstract: A method for detecting a cancer cell, including: contacting in vitro a peripheral blood-containing sample including test cells and a labeling substance; allowing the test cells to incorporate the labeling substance to label the test cells; and detecting, as a cancer cell, a cell showing a higher degree of labeling with the labeling substance than that shown by a normal cell in the peripheral blood-containing sample.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 9, 2017
    Assignee: ARKRAY, Inc.
    Inventors: Hidenori Takagi, Hiroshi Ito, Masahiro Kozuka
  • Patent number: 9588033
    Abstract: A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: March 7, 2017
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Michael Zahniser, Russell Zahniser
  • Patent number: 9471991
    Abstract: A method comprising: mapping an image onto multiple level sets connected by multiple branches, wherein each of said level sets corresponds to a predefined range of values for an attribute of said image; associating multiple pixels of said image to said multiple level sets in accordance with the value of each pixel; identifying a source level set associated with a source pixel of said multiple pixels; for each of said multiple pixels, determining that a distance between said source pixel and one of said multiple pixels is within a predefined threshold, wherein said distance is calculated as a function of a first distance between said source level set and said level set associated with said one of said multiple pixels; in one embodiment, the determined distance is applied to an image processing application to produce a processed image, and the processed image is rendered on a rendering medium.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: October 18, 2016
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Anastasia Dubrovina, Rom Hershkovitz, Ron Kimmel
  • Patent number: 9448230
    Abstract: The Inventors disclosed an inexpensive method of determining fetal hemoglobin (HbF) in red blood cells of individuals with sickle cell anemia undergoing hydroxyurea treatment. The method is based on the specific elution and measurement of sickle hemoglobin (HbS) from red blood cells, wherein the amount of HbF may be determined according to the formula: HbF=Total hemoglobin?HbS. The method may also be used to determine the amount of HbF in individuals without sickle cell anemia by the specific elution of adult or normal hemoglobin (HbA) from red blood cells whereby the amount HbF may be determined according to the formula: HbF=Total hemoglobin?HbA. The method will also determine levels of HbS or HbA in individuals with sickle cell and without sickle cell respectively. The methods have the advantage of being easy to practice in underdeveloped countries.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: September 20, 2016
    Assignee: Saint Louis Univeristy
    Inventor: Timmy Ray Randolph
  • Patent number: 9292729
    Abstract: A method for analysing microbial growth on a solid culture medium, the method including obtaining image data of the solid culture medium and any microbial growth, generating an associated feature vector of values obtained by applying one or more filters to the image data, using a classifier to classify each pixel in a plurality of pixels in the image data based on the associated feature vector, analysing results of pixel classifications of each said pixel to derive a microbiological assessment of the solid culture medium and any microbial growth, and outputting the microbiological assessment.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: March 22, 2016
    Assignee: LBT Innovations Limited
    Inventors: Lusia Halina Guthrie, John Hughes Glasson, Anton John van den Hengel, Rhys Ernst Hill, Benjamin William Stephen Ward
  • Patent number: 9250176
    Abstract: The invention relates to a system for holding a fluid sample, said system comprising a transparent flexible tube for holding said fluid sample, a tube holder for holding said tube, a first flattening element, and second flattening element, wherein said first flattening element and said second flattening element may be moved relative to each other thereby changing said transparent flexible tube from a first state to a second state, where at least a first cross sectional dimension of said tube is smaller in said second state than in said first state.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: February 2, 2016
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Tom Olesen
  • Patent number: 9196043
    Abstract: A method and apparatus for localizing an area in relative movement and for determining the speed and direction thereof in real time is disclosed. Each pixel of an image is smoothed using its own time constant. A binary value corresponding to the existence of a significant variation in the amplitude of the smoothed pixel from the prior frame, and the amplitude of the variation, are determined, and the time constant for the pixel is updated. For each particular pixel, two matrices are formed that include a subset of the pixels spatially related to the particular pixel. The first matrix contains the binary values of the subset of pixels. The second matrix contains the amplitude of the variation of the subset of pixels.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: November 24, 2015
    Assignee: IMAGE PROCESSING TECHNOLOGIES LLC
    Inventor: Patrick Pirim
  • Patent number: 9170256
    Abstract: The disclosure provides a device and a method for performing morphological analysis for erythrocytes, wherein the method for performing morphological analysis for erythrocytes comprises: collecting a morphological image of each of cells in a sample through a Charge Coupled Device (CCD) after amplifying the sample through an automatic microscope; segmenting and positioning the image and extracting target feature parameters after digitizing the image through an image-digital converter; isolating morphological feature parameters of each of the erythrocytes through a classifier established on the basis of the neural network, and normalizing each type of the morphological feature parameters of the erythrocytes through a feature fusion device established on the basis of fuzzy clustering; performing a statistical analysis on each type of normalized parameters obtained or performing a comprehensive statistical analysis according to a plurality of types of parameters, and expressing the result of the statistical analy
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: October 27, 2015
    Assignee: AVE SCIENCE & TECHNOLOGY CO., LTD
    Inventors: Jianwen Ding, Fengliang Zhou, Guangming Liang
  • Patent number: 9097910
    Abstract: As light is allowed to impinge from above a microplate M and an imaging unit 13 (a line sensor 131 and an imaging optical system 132), which moves in a scanning motion along the bottom surface of the microplate M, receives transmitted light, images of wells W formed in the microplate M are captured. The scope of imaging by the line sensor 131 is greater than the diameter of at least one well W, or preferably, encompasses a plurality of wells. When the depth of field of the optical system 132 is 0.6 mm or less, the influence of reflection of side walls of the wells upon the images is reduced.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: August 4, 2015
    Assignee: SCREEN Holdings Co., Ltd.
    Inventors: Hiroshi Ogi, Satoshi Takahashi, Yoshiki Umemoto
  • Patent number: 9041792
    Abstract: At least two chemically different substances of interest of an unstained biological specimen that for each a substance image is generated, indicating for every region of the image an amount of the substance. A multicolor image is generated on the basis of the substance images.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: May 26, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Marinus B. Van Leeuwen, Stein Kuiper
  • Publication number: 20150138334
    Abstract: An image processing device 20 acquires captured images obtained by imaging a sample including a target cell, performs machine learning based on a first image feature quantity, sets a plurality of object regions for detecting the target cell in the captured images, and displays the plurality of object regions in an order determined based on the first image feature quantity of each of the plurality of object regions. The image processing device 20 calculates a second image feature quantity in each of the plurality of object regions, sorts the plurality of displayed object regions in an order of the second image feature quantity similar to the second image feature quantity of a reference object region selected from among the plurality of object regions, and displays the plurality of object regions.
    Type: Application
    Filed: March 29, 2013
    Publication date: May 21, 2015
    Applicant: FUJI XEROX CO., LTD.
    Inventors: Ryoko Usuba, Noriji Kato, Ryota Ozaki, Yukio Kumazawa
  • Patent number: 9036899
    Abstract: A method and system for volumetric quantification of local bone changes includes the steps of loading at least a first and second (cone-beam) computed tomography three dimensional image, registering the first three dimensional image and second three dimensional image to one coordinate system, selecting a region of interest in one of the first three dimensional image or the second three dimensional image.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: May 19, 2015
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventor: Bart Vandenberghe
  • Publication number: 20150117745
    Abstract: This invention relates to a method, a system and a service for analyzing biological liquids like blood and to assess the quality of such liquid. The analysis is made on a plurality of dried drops of the liquid as samples on a substrate, and involves scanning the substrate to create an image of the dried samples on the substrate. The image of the samples is processed in order to segment and qualify the samples into images of defined sample drops for further processing, whereafter they are grouped into at least one group of samples. The samples are analyzed to retrieve the total areas having at least one predetermined color and to retrieve the total areas for each predetermined color in the drops, whereby a ratio is calculated of the total area of the defined sample drops versus the total areas of the at least one predetermined color areas to achieve a quality indication of the liquid.
    Type: Application
    Filed: October 30, 2013
    Publication date: April 30, 2015
    Applicant: Droppi Veripalvelu Oy
    Inventors: Mikko Vapa, Aki Huttunen, Niko Kotilainen, Marko Vapa, Janne Heikkila
  • Patent number: 9020223
    Abstract: The invention relates to a method for non-invasive reproducible determination of a corrected surface on a 3D bone surface model constructed from 3D medical image of a bone having a deformation consisting in a bump overgrowth at the head-neck junction; wherein said corrected surface comprises: i) a 3D spherical corrected surface patch on the head portion of said 3D bone surface model, and ii) a 3D smooth transition corrected surface patch on the neck portion of said 3D bone surface model, contiguous to said 3D spherical corrected surface patch; Said corrected surface patches are defined by a set of parameters comprising: iii) at least one first parameter (a*) representing a spherical extent value of said 3D spherical corrected surface patch, iv) and a set of at least one second parameter, said set determining the 3D correction boundary of said corrected surface patches, such that said corrected surface patches are continuous with said 3D bone surface model along said boundary.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 28, 2015
    Assignee: A2 Surgical
    Inventors: Laurence Chabanas, Stéphane Lavallee, Jerome Tonetti, Thomas Byrd, Bryan Talmadge Kelly, Christopher Larson
  • Patent number: 9017610
    Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: April 28, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: James Winkelman, Milenko Tanasijevic, David Zahniser
  • Publication number: 20150102216
    Abstract: A method for classifier generation includes a step of obtaining data for classification of a multitude of samples, the data for each of the samples consisting of a multitude of physical measurement feature values and a class label. Individual mini-classifiers are generated using sets of features from the samples. The performance of the mini-classifiers is tested, and those that meet a performance threshold are retained. A master classifier is generated by conducting a regularized ensemble training of the retained/filtered set of mini-classifiers to the classification labels for the samples, e.g., by randomly selecting a small fraction of the filtered mini-classifiers (drop out regularization) and conducting logistical training on such selected mini-classifiers. The set of samples are randomly separated into a test set and a training set.
    Type: Application
    Filed: September 15, 2014
    Publication date: April 16, 2015
    Inventors: Heinrich Röder, Joanna Röder
  • Patent number: 8989466
    Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: March 24, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Kenton C. Hasson, Gregory A. Dale, John P Keady
  • Patent number: 8989476
    Abstract: A method for automatically rapidly analyzing biological cells includes continuously capturing a plurality of image frames of a suspension including a plurality of biological cells according to a predetermined time interval within a predetermined time using a low-magnification optical image amplification device of a image capture device; transmitting each of the plurality of image frames to an operation processing device; the operation processing device utilizing an image identification technology to detect a number of the plurality of biological cells in an image frame and a static data of each biological cell of the plurality of biological cells according to at least one parameter; and the operation processing device generating a dynamic data of each biological cell in the image frame according to the static data of each biological cell in the image frame and the static data of each biological cell of a previous image frame.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: March 24, 2015
    Inventors: Hsian-Chang Chen, Chun-Shui Huang
  • Patent number: 8983167
    Abstract: A variation of a method for estimating a quantity of a blood component in a fluid canister includes: within an image of a canister, identifying a reference marker on the canister; selecting an area of the image based on the reference marker; correlating a portion of the selected area with a fluid level within the canister; estimating a volume of fluid within the canister based on the fluid level; extracting a feature from the selected area; correlating the extracted featured with a concentration of a blood component within the canister; and estimating a quantity of the blood component within the canister based on the estimated volume and the concentration of the blood component within the canister.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: March 17, 2015
    Assignee: Gauss Surgical
    Inventors: Siddarth Satish, Ali Zandifar, Kevin J Miller
  • Patent number: 8977020
    Abstract: An image processing device 100 divides a hollow organ 50 extracted from a volume image 40 using a plurality of planes 20 including an arbitrary eye vector 23 or a plurality of planes along the centerline of the hollow organ 50, transforms the coordinates of a point inside the hollow organ 50 along a predetermined convex surface set outside the hollow organ 50 on each plane 20, and gives a pixel value of an original position to a corresponding point after the coordinate transformation. Then, a folded volume image is generated by combining the respective planes 20 in a reverse procedure of the division procedure, and a shaded folded three-dimensional image 90 is generated by projecting the folded volume image to a projection surface from the arbitrary viewing direction and is displayed on a display device 107.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: March 10, 2015
    Assignee: Hitachi Medical Corporation
    Inventor: Yoshihiro Goto
  • Patent number: 8977030
    Abstract: A blood cell image display apparatus comprising: a classifier for classifying blood cell images, which are obtained by imaging a blood smear prepared from a blood specimen, in accordance with types of blood cells in the blood cell images; an information receiver for receiving information relating to the blood specimen; a display section; and a display controller for determining a type of blood cell as a display object on the basis of the information relating to the blood specimen, and displaying a blood cell image classified as the determined type on the display section, is disclosed. A specimen analyzing system, a blood cell image display method, and a computer program product are also disclosed.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: March 10, 2015
    Assignee: Sysmex Corporation
    Inventor: Kazuhiro Yamada
  • Patent number: 8971600
    Abstract: An ultrasonic diagnostic apparatus is provided for displaying a color map on which a difference in blood flow dynamics is reflected. Setting a test subject who is administered a contrast agent is assumed as an imaging target, and a probe transmits and receives ultrasonic waves to and from the target for contrast imaging. Image data is constructed based on signals received by the probe and a time-intensity curve is generated from intensity values of the image data. According to the time-intensity curve, a value of a predetermined parameter is calculated for producing a distribution image of blood flow dynamics. The distribution image (color map) of the blood flow dynamics is produced from the parameter value. The color map is a two-dimensional or a three-dimensional image being color-coded according to the parameter value.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: March 3, 2015
    Assignee: Hitachi Medical Corporation
    Inventors: Hideki Yoshikawa, Takashi Azuma
  • Patent number: 8964171
    Abstract: Methods and systems for identifying reticulocytes in a blood sample deposited on a substrate include: illuminating the sample with incident light at two different wavelengths, obtaining a two-dimensional image of the sample corresponding to a first one of the wavelengths, and obtaining a two-dimensional image of the sample corresponding to a second one of the wavelengths; analyzing the images to identify a set of representative red blood cells; determining an area of each of the red blood cells in the set; determining a color value of each of the red blood cells in the set; and, for each one of the red blood cells in the set, identifying the red blood cell as a reticulocyte if the area of the red blood cell exceeds an area cutoff value and the color value of the red blood cell is less than a color cutoff value.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 24, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Michael Zahniser, Russell Zahniser
  • Patent number: 8958618
    Abstract: A computer implemented method identifying calcification in a patient image data set including blood vessels.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: February 17, 2015
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventors: Saad Masood, Brian Mohr, Costas Plakas
  • Patent number: 8942423
    Abstract: In one embodiment, a method of detecting centerline of a vessel is provided. The method comprises steps of acquiring a 3D image volume, initializing a centerline, initializing a Kalman filter, predicting a next center point using the Kalman filter, checking validity of the prediction made using the Kalman filter, performing template matching, updating the Kalman filter based on the template matching and repeating the steps of predicting, checking, performing, and updating for a predetermined number of times. Methods of automatic vessel segmentation and temporal tracking of the segmented vessel is further described with reference to the method of detecting centerline.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: January 27, 2015
    Assignee: General Electric Company
    Inventors: Kedar Anil Patwardhan, Sandeep N. Gupta, David M. Mills, Aaron M. Dentinger, Yongjian Yu
  • Patent number: 8942458
    Abstract: A method for distinguishing and sorting cells characterized by comprising distinguishing and sorting a specific cell mass or a part of the cells in the cell mass with the use of transmitted light data reflecting the morphological characteristics of the cells such as size and shape optionally together with side-scattering light data reflecting the characteristics of the internal structure of the cells. The part of the cells in the specific cell mass as described above are at the G1 stage or at a part of the M stage in the cell cycle. A part of the cells at the G1 stage are referred to as the left bottom line in an analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data, while a part of the cells at the M stage are referred to as the right bottom line in the analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: January 27, 2015
    Assignee: Furukawa Electric Co., Ltd.
    Inventors: Toru Takahashi, Ken Tsukii, Jie Xu
  • Patent number: 8929639
    Abstract: Provided is an image processing apparatus capable of analyzing a target sample image with high accuracy in line with a phenomenon occurring in the target sample. The image processing device includes: a dye spectrum storage portion (233) for storing a dye spectrum of a dye used in staining the stained sample; and an arithmetic portion (250) including: a variation characteristic calculating portion (2501) for calculating, based on the stored dye spectrum, a variation characteristic representing either a sharp or gradual change of the dye spectrum in the wavelength direction; and a dye-amount/variation-amount estimating portion (2503) for estimating, based on the stored dye spectrum and the calculated variation characteristic, a variation amount from a pixel value of each pixel forming the stained sample image based on the dye-amount and the variation characteristic, the arithmetic portion analyzing the stained sample image at least based on the variation amount.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: January 6, 2015
    Assignee: Olympus Corporation
    Inventor: Takeshi Otsuka
  • Patent number: 8922342
    Abstract: Systems, apparatus, and methods for continuously authenticating individuals are provided. A continuous authentication system receives first biometric authentication information from an individual. The system compares the first biometric authentication information to stored first biometric information to identify the individual and links the identified individual to a device for obtaining second biometric authentication information. The device for obtaining second biometric authentication information continuously receives second biometric authentication information. The continuous authentication system compares the received second biometric authentication information to stored second biometric information that corresponds to the individual to determine if the received second biometric authentication information corresponds to the individual.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: December 30, 2014
    Assignee: Noblis, Inc.
    Inventors: Timothy Patrick Ashenfelter, George Ihor Kiebuzinski, John R. Mercier, Matthew K. Monaco, Lawrence Dennis Nadel, Jonathan Mark Phillips, Daniel Farlow Uyesugi
  • Patent number: 8923595
    Abstract: A method is described for distinguishing between cancerous and normal human cells. The method includes collecting cells; preparing cells for scanning; scanning of the prepared cells by means of atomic force microscopy; processing of the obtained images through specific algorithms; wherein the algorithms allowing one to identify whether the cell is cancerous or normal.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: December 30, 2014
    Assignee: Clarkson University
    Inventors: Igor Sokolov, Maxim Dokukin
  • Patent number: 8922761
    Abstract: A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: December 30, 2014
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Michael Zahniser, Russell Zahniser
  • Publication number: 20140376816
    Abstract: A device (1) for sorting objects immersed in a flowing medium is described. The device comprises a holographic imaging unit comprising a plurality of holographic imaging elements (2), a fluid handling unit comprising a plurality of microfluidic channels (3) for conducting flowing medium along a corresponding holographic imaging element (2) and comprising a microfluidic switch (5) arranged downstream of an imaging region in the microfluidic channel for controllably directing each object in the flowing medium into a selected one of a plurality of outlets (6). The device also comprises a processing unit (7) adapted for real-time characterization of the holographic diffraction image obtained for each of the objects thereby taking into account at least one predetermined object type signature. The processing unit (7) furthermore is adapted for controlling the microfluidic switch (5) in response to the characterization.
    Type: Application
    Filed: December 7, 2012
    Publication date: December 25, 2014
    Applicants: Katholieke Universiteit Leuven, KU LEUVEN R&D, IMEC
    Inventors: Liesbet Lagae, Peter Peumans, Kris Verstreken, Dries Vercruysse, Chengxun Liu
  • Publication number: 20140369589
    Abstract: A diagnosis assistance apparatus for assisting a diagnosis using schemas includes a storage section that stores a plurality of different schemas each configured by a figure representing a body region, an acquiring section that acquires results of a plurality of examinations that are performed on an examination target, a schema refining section that refines a schema of a body region related to a disease that is predicted from the acquired examination results, from the schemas step-by-step in accordance with progress of the examinations, and a displaying section that displays the schema refined by the schema refining section.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 18, 2014
    Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, Nihon Kohden Corporation
    Inventors: Kazuo NAKAZAWA, Michiaki IWATA, Miyuki HAYASHI, Tatsuo YOSHIDA, Tatsuo NISHIHARA, Koji TAKIZAWA
  • Publication number: 20140355863
    Abstract: An image processing apparatus according to an embodiment includes an input extraction unit, and a parameter estimation unit. The input extraction unit configured to extract, from time sequence images of medical images obtained by performing a blood perfusion imaging scan on a tissue, a region where a main vessel supplying blood input to the tissue is located as an input part and obtain, based on the input part, a time-density sequence of the blood input as an input time sequence. The parameter estimation unit configured to estimate parameters in a model representing the change of the blood flow at each point in the tissue with the input time sequence, based on the input time sequence, the model and the time sequence images, wherein the parameters include a delay undergone by the blood when flowing from the input part to each point in the tissue.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 4, 2014
    Applicants: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventors: Cui XU, Heng Hu, Shigeharu Ohyu
  • Publication number: 20140348412
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Application
    Filed: August 12, 2014
    Publication date: November 27, 2014
    Inventor: Charles A. TAYLOR
  • Patent number: 8891850
    Abstract: Digital evaluation of cellblock preparations to determine the type and extent of disease in order to identify the best approach for treatment without the need for additional testing or sampling.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: November 18, 2014
    Assignee: The University of Kansas
    Inventors: Ossama Tawfik, Brian Potetz
  • Patent number: 8891851
    Abstract: A home healthcare management system wherein a patient conducts self diagnoses and self testing, and manages their own medical records at home. A digital microscope is utilized as part of the system that is smaller, of lower cost, faster, of a higher dynamic range, and has a higher resolution than conventional microscopes. The microscope consists of an illumination source, a spatial sub-sampling device and a detector device. The digital microscope provides a vectored method of collecting images from a digital microscope that is independent of the optical resolution, and a slide based coordinate system, and a method of displaying images and communicating such images over the Internet in a file format that does not require a header or prior knowledge of magnification, coordinate system, or tiling structure. The system further includes an interface for physiological monitoring devices and a connection to the Internet for more comprehensive services.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: November 18, 2014
    Inventor: Glenn F. Spaulding
  • Publication number: 20140334712
    Abstract: A method and apparatus for determining hemoglobin concentration is provided. A method aspect includes the steps of: a) depositing an unlysed, substantially undiluted blood sample into an analysis chamber adapted to quiescently hold the sample for analysis; b) imaging the sample in a region of the analysis chamber where the height of the chamber is no more than about twenty microns (20?) or no less than about two microns (2?), to produce image signals representative of the optical density of the imaged region; c) determining a sample representative optical density value using the image signals representative of the optical density of the imaged region; and d) determining the hemoglobin concentration of the sample using the sample representative optical density value.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 13, 2014
    Applicant: Abbott Point of Care, Inc.
    Inventor: Darryn W. Unfricht
  • Patent number: 8885912
    Abstract: A computer implemented method of analyzing tissue features based on multiplexed biometric images includes storing a data set including cell profile data and an assessment associated with a field of view or a patient. The cell profile data includes biomarker expression intensity data for at least one cell feature. The method includes normalizing the biomarker expression intensity data for each field of view. The method includes determining a plurality of positive cell percentages for a first cell feature for each field of view or for each patient based on a plurality of normalized expression cutoffs for all fields of view. The method further includes correlating positive cell percentages with assessments for each field of view or each patient. The method also includes identifying a combination of a cell feature for expression of a biomarker and a normalized expression cutoff that most closely correlate the positive cell percentage with the assessment.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: November 11, 2014
    Assignee: General Electric Company
    Inventor: Yunxia Sui
  • Patent number: 8873827
    Abstract: Exemplary embodiments enable determination of spatial proximity between two or more features in biological tissue. An exemplary method includes identifying a morphological feature in an image of the biological tissue based on expression levels of a first biomarker indicative of the morphological feature, and receiving a result of a segmentation analysis performed on the image of the biological tissue identifying a set of morphological units in the image external to the morphological feature. An exemplary method includes determining an expression level of a second biomarker corresponding to each unit in the set of morphological units in the image of the biological tissue, and determining a spatial distance between the morphological feature and each unit in the set of morphological units.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: October 28, 2014
    Assignee: General Electric Company
    Inventors: Colin Craig McCulloch, Christopher James Sevinsky, Jingyu Zhang
  • Publication number: 20140309795
    Abstract: Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 16, 2014
    Inventors: Pierce O. Norton, Vladimir Azersky
  • Publication number: 20140307940
    Abstract: Apparatus and methods are described for automatically performing set-up steps for flow cytometry operations. The invention provides for the spatial determination of a flow stream and the subsequent automatic alignment of analysis devices and/or collection vessels. The automatic determination of flow stream properties provides for the automatic configuration flow cytometer parameters.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 16, 2014
    Inventors: Pierce O. Norton, Vladimir Azersky