Abstract: The present invention relates to the field of sterilization of items that are sensitive to e.g. temperature, pH, positive or negative pressure, radiation or oxidation. More particularly, the invention concerns a method, the use of this method and an apparatus for sterilization or disinfection, comprising the steps of contacting one or more item or part of an item with (a) a water-based fluid containing at least one enzyme, and (b) a substantially water-free environment with a gas having oxidative properties, where said step (a) precedes said step (b). According to the invention, items can be sterilized that are otherwise impaired by conventional sterilization procedures, such as laboratory items, medical items, dental items, military items, biological items, and food processing-related items.

Abstract: A method and apparatus provides for sterilizing a device in a container. The method comprising the steps of: a) placing the device into the container; b) processing the device, the container and a lid for the container in a sterilization process with the lid separated from the container; and c) after sterilizing a contact surface on the container where the lid meets the container, and while maintaining the container and the lid in a sterile environment, placing the lid onto the container, whereby to prevent contamination of the device upon its removal from the container via contact with the contact surface.

Abstract: A method and composition for generation of a microbubble from a nanoparticle through a non-thermal method, preferably featuring nucleation.

Abstract: The invention relates to a supersonic bactericidal method and facilities containing chitosan, consisting of a bactericidal liquid and a supersonic atomizer. The bactericidal liquid is composed of water (X) and chitosan (Y), with a preferable ratio, X: Y=500:1. However, other ratios are available, too. The supersonic atomizer is preferably operated under a catalysis frequency between 2.4˜3.6 MHZ. So, when the bactericidal liquid is atomized through the supersonic atomizer, it is to be atomized having a diameter ranging from 300 nm to 150 nm, experimentally approved to have a significant bactericidal effect and be able to relatively save energy.

Abstract: An exemplary dust removing apparatus applicable for removing dust or dirt from a surface of an optical lens is provided. The dust removing apparatus includes an ultrasonic oscillation device, at least a dust removing device, and a tray. The ultrasonic oscillation device is configured for causing an ultrasonic vibration of the optical lens so as to weaken an adhesive force between the optical lens and the dust on the surface thereof. The dust removing device is configured for removing the dust from the surface of the optical lens. The tray is disposed on the ultrasonic oscillation device and located between the ultrasonic oscillation device and the dust removing device. The tray is configured for supporting the optical lens. A dust removing method is also provided.

Abstract: The invention is an apparatus and methods for optimizing the performance and protecting one or more aerosol generating transducers from deterioration while operating in a chemically reactive aqueous solution by utilizing one or more protective barrier techniques to eliminate chemical interaction between the aqueous solution and the transducers, among other features of the generator including these transducers. The method of the present invention produces an aerosol producing transducer with the transducer housing and assembly to be constructed in such a way as to assure its efficient and effective long-term and problem free operation in an aqueous solution that is chemically reactive.

Abstract: The invention relates to a extensional flow layer-separating reactor comprising a channel, in which at least two educt products and at least one separation fluid for spatially separating said two products are introduced, an extension area which is adjacent to the channel in such a way that the educt product and the separation fluid which are drawn in substantially laminar layers, flow at a greater speed and a turbulence generating device for generating the turbulent micro mixture of the educt products.

Abstract: A device for sanitizing and disinfecting a space includes a tank having an interior space for holding an aqueous sanitizing, disinfecting, and/or sterilizing liquid, a bottom sector, an air inlet sector, and an exhaust sector, inner walls of the exhaust sector and the air inlet sector forming a substantially “V”-shaped air pathway within the interior space. A liquid cascading reactor vessel is positioned within the bottom sector of the tank, a top edge of the reactor vessel in adjustably spaced relation from a notch in the “V”-shaped air pathway. A vibratable ultrasonic head array is positionable within and beneath a top edge of the reactor vessel and is submergable within the reactor vessel for vibrating the disc to form atomized micro-particles from the liquid. Air can be drawn into the air inlet, and the formed atomized micro-particles can be exhausted from the exhaust outlet.

Abstract: An autoclave reactor for treating municipal solid waste (MSW) including agricultural waste and medical waste wherein the MSW may be encapsulated in plastic bags. The reactor is equipped with a loading internal guiding means for treating the waste in such a manner as to decompose the organic fraction into a pulp which acts as a fluid whereby rigid, material such as metal and glass may be removed by known means. The reactor may also be equipped with: (a) piercing and cutting devices for rupturing the encapsulating material thereby expelling air and releasing the contents, (b) means for collecting vapours and emissions for treatment before they are released into the environment, (c) a vacuum means for removing vapours and drying the resulting products, (d) a sensing means which determines the viscosity of the reactor contents and this information is fed into a computer which determines when the desirable decomposition has been reached.

Abstract: A solution reactor allows the solution L to contact with the reactant gas G, and the component contained in the solution L is chemically changed by means of the reactant gas G. The reactor includes a nozzle 41 for spraying the solution L into a state of mists M, and a pressure feed unit 42 for feeding the reactant gas G, which is pressurized, into the nozzle 41. Further, in the reactor, the pressure feed unit 42 feeds such pressurized reactant gas G to the nozzle 41 to be flown fast, so that the nozzle 41 allows the fast flowing reactant gas G to contact with the solution and the solution L is broken into the state of mists M to be jetted out, and thus the component contained in the solution L is chemically changed by means of the reactant gas G.

Abstract: A one-quarter wave separation chamber of an ultrasound resonator is effective at particle/fluid/living cell separation, and can integrate with a sterile-disposable kit. Resonator is part of a continuous flow closed system, and can replace the centrifuge for blood separation into constituents. Resonator is optically monitored for cell type/volume near each exit port to control outlet valves maintaining collection purity. Uncollected cells/plasma can return to donor patient. Apheresis benefits: less extra corporeal blood volume, decreased processing time, smaller system size, lower instrument cost, reduced haemolysis, and lower cost kits. The separation chamber of the kit can be efficiently coupled acoustically to the resonator body using evacuating sealing gaskets surrounding the interface. Cooling medium can flow through resonator counteracting temperature increase tendency with higher power applications.

Abstract: Devices and methods for treating, preventing from growth, and neutralizing microorganisms in cutting fluids using high-frequency, low-energy ultrasound.

Abstract: In the present invention, petroleum is separated into hydrocarbon mixtures having different components at an atomizing step and a collecting step. At the atomizing step, the petroleum is ultrasonically vibrated and is discharged and atomized in a state of an atomized fine particle floating in a carrier gas. At this step, the petroleum is separated into a mixed fluid containing the atomized fine particle and the carrier gas and residual petroleum which is not atomized. At the collecting step, the hydrocarbon mixture is separated and collected from the mixed fluid obtained at the collecting step. In the separating method, the petroleum is separated into the residual petroleum and the mixed fluid at the atomizing step, and the mixed fluid is collected at the collecting step so that the petroleum is separated into hydrocarbon mixtures having different components.

Abstract: An ultrasonic treatment chamber and a process for ultrasonically treating a liquid in an ultrasonic treatment chamber include an elongate, generally tubular housing having an inlet and an outlet spaced longitudinally from the inlet. Liquid is directed into the housing at the housing inlet for longitudinal flow within the housing to the housing outlet. Mechanical ultrasonic vibration is generated within the housing in direct contact with the liquid flowing within the housing, with the direct contact being upstream of the housing outlet. A standing acoustic wave is produced within the housing with the standing acoustic wave having a node spaced longitudinally from the housing outlet.

Abstract: An apparatus, system and method for preventing or treating biofilm associated with catheters. A piezo-ceramic element may be attached to a catheter, and a vibration processor may be connected to the piezo-ceramic element. The vibration processor may provide electric signals that generate acoustic vibrations in the piezo-ceramic element, causing vibrations in or around the catheter. These vibrations may be particularly administered to disperse microbe colonies, thereby preventing or inhibiting formation of biofilm that may lead to infections. Vibrations may be amplified significantly due to resonance conditions in the catheter balloon, which may be powerful enough to be used to disperse microbe colonies that have grouped around the catheter or are attempting to do so.

Abstract: A method for treating electrocoating fluids involves exposing the electrocoating fluid to high-frequency ultrasound while emitting microbubbles into the electrocoating fluid. In further embodiments, the method includes emitting electromagnetic radiation into the fluid. In other embodiment, the method includes routing electrocoating fluid into a compartment. An apparatus for treating electrocoating fluids comprises a compartment (2) configured to hold electrocoating fluid, at least one ultrasound emitter (1) configured to emit high-frequency ultrasound (4) into the compartment (2), and a microbubble emitter (3) configured to emit microbubbles (5) into the compartment (2). In further embodiments, the apparatus may be in fluid communication with an external electrocoating bath. In other embodiments, the apparatus may include an electromagnetic radiation emitter (12), which may emit visible light into the compartment.

Abstract: A method of assembling multiple port assemblies in a cavitation chamber is provided. The method is comprised of boring at least two ports of different sizes in a cavitation chamber wall of the cavitation chamber. The external port diameter of the smaller port is smaller than that port's internal port diameter. A member selected from the group consisting of windows, plugs, feed-throughs, sensors, transducers and couplers is inserted into the chamber through the larger port and positioned within the smaller port. The member can be secured within the smaller port with an adhesive. A mounting ring/retaining ring, retaining coupler or port cover seals the second, larger port. A second member selected from the group consisting of windows, plugs, feed-throughs, sensors, transducers and couplers can be positioned within a cone-shaped port within the mounting ring or retaining coupler. A feed-thru, sensor, transducer or coupler can be integrated into the port cover.

Abstract: Fluids in a vessel are subjected to a high ultrasonic intensity, by means of several ultrasonic transducers attached to a wall of the vessel, each transducer (14) radiating no more than 3 W/cm2, the transducers being sufficiently close to each other, and the number of transducers being sufficiently high, that the power dissipation within the vessel is at least 25 W/liter. The number of transducers, the power of the transducers, and the volume of the vessel may be such that the power density is between 40 and 80 W/liter. The vessel may be double walled, and the space between the two walls be filled by a low attenuation buffer liquid (36) whose cavitation threshold is above that of the liquid being treated.

Abstract: A device for reducing microorganisms comprising: an outer cylinder which liquid to be processed flows into; a mesh inner cylinder which is disposed inside the outer cylinder; and an ultrasonic oscillator which is disposed inside the mesh inner cylinder.

Abstract: Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.

Abstract: An acoustic system for applying vibratory energy including a horn connected to an ultrasonic energy source. The horn defines an overall length and wavelength, and at least a leading section thereof is comprised of a ceramic material. The leading section has a length of at least ? the horn wavelength. In one preferred embodiment, an entirety of the horn is a ceramic material, and is mounted to a separate component, such as a waveguide, via an interference fit. Regardless, by utilizing a ceramic material for at least a significant portion of the horn, the ultrasonic system of the present invention facilitates long-term operation in extreme environments such as high temperature and/or corrosive fluid mediums. The present invention is useful for fabrication of metal matrix composite wires.

Abstract: Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1-50 MHz is used and the sample or tissue receives 0.1-200 W/cm2 of ultrasound intensity. The use of ultrasound allows much shorter times in the methods. Also presented are apparati comprising transducers of one or of multiple heads for producing the ultrasound radiation and further comprising a central processing unit and optionally comprising one or more sensors. Sensors can include those to measure and monitor ultrasound and temperature. This monitoring system allows one to achieve accurate and optimum tissue fixation and processing without overfixation and tissue damage. The system also allows the performance of antigen-antibody reactions or nucleic acid hybridizations to be completed in a very short time while being highly specific and with a very low or no background.

Abstract: A system for treating meat by the application of a shock wave to the meat while the meat is in contact with a diaphragm which is substantially transparent to the shockwave, confines the meat within a tunnel. In addition, the diaphragm and shock wave generating chamber are preferably disposed above the meat.

Abstract: Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts and methods for determining microbial contamination using the apparatus.

Abstract: A flow cell for the ultrasonic treatment of a liquid includes a housing with a wall at least partially defining a flow chamber therein. The housing includes a first liquid passage and a second liquid passage for flowing the liquid into and out of the flow chamber. An ultrasonic horn extends into the flow chamber for imparting ultrasonic energy to liquid in the flow chamber, the ultrasonic horn having an outer surface and an end surface, and having a recess formed in the end surface. A tubular member having a first end in fluid communication with a second end, is arranged such that the first end is in fluid communication with the second liquid passage, and the second end extends into the recess in the ultrasonic horn.

Abstract: Ultrasound device having a reaction chamber, which includes a magnetostrictive transducer and a horn transmitting ultrasound radiation substantially uniformly throughout the reaction chamber. The horn is hollow and is constituted by a cylinder having an empty inner chamber at its core defining a resonance chamber, which may be cylindrical and may comprise a plurality of sections of cylindrical shape or a central section of larger diameter and two terminal sections of smaller diameter.

Abstract: A device for producing hydrogen includes a container housing a water-based solution and a metal constituent. A generator ultrasonically irradiates the water-based solution in the presence of the metal constituent to produce hydrogen gas.

Abstract: A method and apparatus for treating fluids by transmitting ultrasonic energy into the fluids to produce high intensity cavitations in the fluids as the fluids pass through the apparatus. The fluids are retained in the apparatus for a sufficient period of time to destroy contaminates in the fluids, neutralize acids or bases in the fluids and dissociate other chemical compounds.

Abstract: A method of constructing a port assembly for use with a single piece cavitation chamber, typically a spherical chamber, is provided. The port assembly includes a cone-shaped port, a cone-shaped mounting ring and a central member mounted within the mounting ring. The mounting ring is located within the chamber prior to the final assembly of the chamber itself, i.e., at a time in which the chamber is comprised of multiple pieces. After the final assembly of the chamber is complete, a central member such as a window, plug, gas feed-thru, liquid feed-thru, mechanical feed-thru or sensor assembly is placed within the chamber. The mounting ring is then pulled into place within the cone-shaped port, followed by the central member. To expedite assembly, specialized tools can be used to pull the mounting ring and the central member into place.

Abstract: Devices and methods for treating, preventing from growth, and neutralizing microorganisms in cutting fluids using high-frequency, low-energy ultrasound.

Abstract: A lid for a well plate is provided. Pins penetrate the lid and project downwardly into the wells of the well plate. Thermal energy is applied to the upper end of the pin to regulate the temperature of liquid samples in the well plate. Ultrasonic energy is applied to the upper end of the pin to sonicate the liquid sample. An electrical charge is applied to the upper end of the pin to attract charged materials, such as DNA, and to selectably segregate charged materials from the liquid sample.

Abstract: An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.

Abstract: An ultrasonic horn in accordance with the present invention comprises a horn body having a longitudinal transmission axis, a proximal end attachable at least indirectly to a source of ultrasonic vibrations, and a distal end with an active end face. The end face is provided with a plurality of fingers projecting parallel to one another and to the axis.

Abstract: Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.

Abstract: The present invention provides a device and a method for separating particles from fluids using ultrasound, laminar flow, and stationary wave effects comprising a micro-technology channel system with an integrated branching point or branching fork, and a single ultrasound source. One of the characteristics of the invention is that the single ultrasound source, which generates the standing waves, excites the complete structure including the channel system. No special reflectors or the like are needed. Extremely thin dividers can separate the flow, thereby enhancing the effectiveness of the device. The device could be manufactured in silicon and the ultrasound energy could preferably be delivered by a piezoelectric element.

Abstract: According to the present invention, a pre-cleaning process is performed for removing a physical substance such as blood, mucus or tiny pieces of tissue that are attached to the exterior of the medical device and are inside a duct or a hollow portion. Then, the pre-cleaned medical device is immersed in a chlorine dioxide solution and/or a chlorine dioxide solution is passed through the duct or the hollow portion. Thereafter, the medical device is placed in a chlorine dioxide gas atmosphere and/or a chlorine dioxide gas is passed through the duct or the hollow portion. In this manner, the exterior of the medical device and the interiors of the duct and the hollow portion are deodorized, disinfected and sterilized.

Abstract: A new method of producing liposomes is described using an in-line mixing system. The liposomes produced by this method find utility in numerous therapeutic applications.

Abstract: A new method of producing liposomes is described using an in-line mixing system. The liposomes produced by this method find utility in numerous therapeutic applications.

Abstract: The present invention provides a method and a device, by which it is possible to decompose and treat a large amount of organic halogen compounds, etc. which are environmental pollutants, to a low concentration range at which it is dischargeable as waste liquor to sewage in a short time, and it is also possible to decompose organic substances and nitrogen or phosphorus compounds which are hardly decomposable by oxidation.

Abstract: An apparatus for the ultrasonic destruction of microbiological contamination of fluids. The process involves subjecting contaminated fluids to ultrasonic vibration so as to cause cavitation within the fluids. The cavitation results in the destruction of microbial cells and mats of microbial colonies. To create cavitation in the fluids a number of piezoelectric ceramic rings surround a metal tube through which the fluids flows. Those piezoelectric rings are immersed in a transmission medium which is pressurized sufficiently to prevent cavitation occurring in it and causing damage to the piezoelectric rings electrodes. This process is applicable to many liquids such as fuels, lubricating fluids, potable and marine ballast waters, dairy products, pharmaceuticals, liquid food products and beverages.

Abstract: An ultrasonic energy source is used to provide a variable force for measuring the binding forces between molecular entities and for sensing the presence of an analyte in a test sample. The device includes a surface that has a first binding member attached thereto and one or more particles that have a second binding member attached thereto. A reaction vessel is provided for exposing the surface to the particles whereby, if the first binding member has a binding affinity for the second binding member, a complex is formed between individual first binding members and individual second binding members and the particles thereby become immobilized with respect to the surface. The ultrasonic energy source is positioned for applying a variable ultrasonic force onto the surface, and the position of the particles is monitored as the intensity of the ultrasonic force is varied.

Abstract: A method and an apparatus in form of a disinfecting apparatus comprising a steam device for combatting germs on the surface of products, in particular of food products. The apparatus employs a combination of steam and ultrasound to kill germs on the surface of a product which is conveyed past the steam device. Pressurized steam is fed through a steam passage to an opening conveying the steam to a cavity, in which the steam is made to oscillate at a ultrasonic frequency. The oscillations in the steam prevent the steam from heating the products excessively, while germs presents on the surface of the products are heated and killed.

Abstract: A method and apparatus (10) for treating a fluid or materials therein with acoustic energy has a vessel (14) for receiving the fluid with inner walls shaped to focus acoustic energy to a target zone within the vessel. One or more nozzles (26) are directed into the vessel (14) for injecting a condensable vapor, such as steam, into the vessel (14). The system may include a steam source (18) for providing steam as the condensable vapor from an industrial waste heat source. Steam drums (88) are disposed between the steam source (18) and nozzles (26) to equalize and distribute the vapor pressure. A cooling source (30) provides a secondary fluid for maintaining the liquid in the vessel (14) in subcooled conditions. A heating jacket (32) surrounds the vessel (14) to heat the walls of the vessel (14) and prevent biological growth thereon. A pressurizer (33) may operate the system at elevated pressures.

Abstract: Fluids in a vessel are subjected to a high ultrasonic intensity, by means of several ultrasonic transducers attached to a wall of the vessel, each transducer (14) radiating no more than 3 W/cm2, the transducers being sufficiently close to each other, and the number of transducers being sufficiently high, that the power dissipation within the vessel is at least 25 W/litre. The number of transducers, the power of the transducers, and the volume of the vessel may be such that the power density is between 40 and 80 W/litre. The vessel may be double walled, and the space between the two walls be filled by a low attenuation buffer liquid (36) whose cavitation threshold is above that of the liquid being treated.

Abstract: Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.

Abstract: Apparatus and method for sterilization of liquid includes a liquid container containing a liquid and having a piezoceramic ring that is connected to a power supply system. Power supply system supplies electric signals to the piezoceramic ring that are transformed into mechanical waves and cause vibrations in the liquid.

Abstract: The cross-wave sonicator has a simple structure and yet can achieve disintegration of cells or tissues so as to remove DNA, RNA or other substances therefrom. The sonicator has a processing tank provided with side walls, the lower portions of which are bent inward to form inclined walls respectively. Ultrasonic wave transducers are attached on external surfaces of the inclined walls to radiate ultrasonic waves such that they intersect orthogonally with each other within the processing tank to generate high energy around samples to be treated, thus achieving sonication of the samples.

Abstract: A flow cell for the ultrasonic treatment of a liquid includes a housing with a wall at least partially defining a flow chamber therein. The housing includes a first liquid passage and a second liquid passage for flowing the liquid into and out of the flow chamber. An ultrasonic horn extends into the flow chamber for imparting ultrasonic energy to liquid in the flow chamber, the ultrasonic horn having an outer surface and an end surface, and having a recess formed in the end surface. A tubular member having a first end in fluid communication with a second end, is arranged such that the first end is in fluid communication with the second liquid passage, and the second end extends into the recess in the ultrasonic horn.

Abstract: Active acoustic piping that allows treatment of material flowing in a piping system is disclosed. Treatment of waste water and other fluids is enabled, where acoustic radiation operates on the flow material. An inner pipe has a plurality of transducer elements disposed on its external perimeter. A buffer zone around the transducer elements provides an acoustic impedance mismatch, which concentrates the acoustic energy into the flow material traveling in the inner pipe. Processes such as decontamination, flow unclogging, fluid and particulate mixing, particulate size reduction, and particulate separation are enabled. No pressure compensation scheme is required.

Abstract: A new method of producing liposomes is described using an in-line mixing system. The liposomes produced by this method find utility in numerous therapeutic applications.