Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.

Abstract: Methods for the gas-phase delivery of gases, such as process gases, from the gas phase of a multicomponent source liquid are provided. The methods are generally directed to the generation of process gases having mass flow rates which are proportional to the input power delivered to the multicomponent source liquid containers. The methods may be used to deliver process gases to critical process applications.

Abstract: The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.

Abstract: The present disclosure generally relates to an ozone sanitizing system and method. In one embodiment, a system for sanitizing various objects using ozone gas is disclosed. The system comprises an ozone generating device configured to generate ozone gas for sanitizing one or more objects, and a vessel configured to couple with the ozone generating device for receiving the ozone gas to sanitize the one or more objects stored inside the vessel during an ozone sanitizing cycle. The system is configured to recirculate at least a gas mixture generated during the ozone sanitizing cycle to increase an ozone concentration inside the vessel.

Abstract: Systems and methods are provided for the removal of endotoxins from fluids. The methods can include the use of polymeric nanoparticles for binding endotoxins present in a fluid. The polymeric nanoparticles can be associated with a support member. The polymeric nanoparticles can have an endotoxin removal capacity of at least 1×109 endotoxin units per gram of polymeric nanoparticle (EU/g) and/or a removal efficacy per unit surface area of the polymeric nanoparticles of at least 1×106 EU/cm2.

Abstract: The present disclosure relates to a multi-step method for processing peroxygen solutions for reuse or disposal. The method uses an enzyme and a reducing agent.

Abstract: An incubator includes filters in supply passages for supplying an environment-adjusting-medium. Divergent passages are connected to portions of the supply passages upstream from the filters. The divergent passages converge to a single supply/exhaust passage, which is provided with a pump. By driving the pump in a forward or reverse direction, decontamination gas is pumped from a culture space and discharged outside, and open air is introduced into the culture space. After sucking the contamination gas to adsorb it on the filter, open air is introduced so that the contamination gas is discharged into the culture space 6.

Abstract: The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.

Abstract: Fumigation systems and processes that are especially applicable for the fumigation of perishable (or otherwise sensitive to temperature) agricultural products as the temperature conditions under which the product is being treated are closely controlled to advantageously prevent the product from being exposed to temperature drops and/or spikes during the fumigation cycle. In addition, the present invention incorporates an air filtration system as a part of the fumigation system to substantially remove the toxic fumigant residuals from the air before it is exhausted into the open atmosphere, which typically occurs at the completion of a fumigation cycle. As such, the harmful effect of the fumigant on the products and the surrounding environment and work areas is greatly minimized. In summary, the systems and processes of the present invention provide the ability to conduct fumigations in a well-controlled environment.

Abstract: A system for decontaminating a medical device includes a decontamination chamber configured to retain the medical device and a chemical dispersion assembly configured to deliver a decontaminating fluid to the decontamination chamber. A pressure control assembly is connected to the decontamination chamber and configured to control the pressure in the decontamination chamber. The system also includes a system controller configured to control the decontamination chamber, chemical dispersion assembly, and pressure control assembly. A pressure in the decontamination chamber is reduced to within a sub-atmospheric pressure range in a first evacuation step and add a decontaminating fluid into the decontamination chamber at a first rate while increasing the pressure in the decontamination chamber. Adding the decontaminating fluid increases a relative humidity in the decontamination chamber to a level that improves the efficacy of the decontaminating fluid.

Abstract: The disclosure relates to an apparatus (10) for decontaminating an enclosure that includes a passage having an inlet (18) to receive a carrier gas from the enclosure, an outlet (31) to discharge the carrier gas to the enclosure, a fan (21) for causing a low of carrier gas through the passage from the inlet to the outlet, and a vapour generator (19) where a decontaminant vapour is introduced into the flow of carrier gas to be discharged with the flow at the outlet to decontaminate the enclosed space. A further fan (33) delivers a separate flow of gas from the enclosure bypassing the passageway in which the decontaminant vapour is introduced to be delivered into the enclosure from outlet vents (32) adjacent the vapour outlets (31) to assist in dispersing the carrier gas containing decontaminant vapour throughout the enclosure.

Abstract: Nanoparticles as described herein are configured to bind to bacterial contaminants, such as Gram positive bacteria, Gram negative bacteria, and endotoxins. The nanoparticles include a core comprising a magnetic material; and a plurality of ligands attached to the core. The ligands include, for example, bis(dipicolylamine) (“DPA”) coordinated with a metal ion, e.g., Zn2+ or Cu2+, to form, e.g., bis-Zn-DPA or bis-Cu-DPA, which can bind to the bacterial contaminants. The nanoparticles can be included in compositions for use in methods and systems to separate bacterial contaminants from liquids, such as liquids, such as blood, e.g., whole or diluted blood, buffer solutions, albumin solutions, beverages for human and/or animal consumption, e.g., drinking water, liquid medications for humans and/or animals, or other liquids.

Abstract: Methods for degrading contaminant nucleic acid. The methods use combinations of metal ions and peroxide ions to produce a variety of oxidative species that degrade nucleic acid. Methods of the invention are useful for decontaminating laboratory equipment or solutions. After the equipment or solutions have been decontaminated, the metal ion and peroxide ion solution can be deactivated by raising the temperature to dissociate the peroxide or by binding the metal ions, e.g., with a chelating agent.

Abstract: Contaminants are filtered from a fluid flow stream and the filter is regenerated by a process including steps of: providing a filter material comprising both carbon and potassium iodide; passing a contaminated fluid stream in contact with the filter material; adsorbing contaminants from the fluid stream onto surfaces in the filter material; passing an electric current through the filter material with adsorbed contaminant thereon; disassociating contaminant from the surfaces of the filter material; and removing disassociated contaminant from the filter material by carrying away the disassociated contaminant in a fluid flow mass. Separately, a stable, active iodine solution is also provided for numerous deodorizing and disinfecting applications.

Abstract: Treating absorbable sutures that have been sterilized using ethylene oxide with carbon dioxide at or near its supercritical pressure and temperature conditions to remove any residual ethylene oxide.

Abstract: A method for sterilization according to the present invention comprises: a first sterilization step of providing a sterilization subject in a sealed sterilization chamber and sterilizing the sterilization subject by providing ozone inside the sterilization chamber; a first decomposition step of decomposing the ozone inside the sterilization chamber; a first vacuumization step discharging the gas inside the sterilization chamber and reducing the pressure inside the sterilization chamber; a second sterilization step of providing hydrogen peroxide into the vacuumized sterilization chamber to sterilize the sterilization subject; a third sterilization step of providing ozone into the sterilization chamber; a second decomposition step of decomposing the hydrogen peroxide and ozone inside the sterilization chamber; and a second vacuumization step of discharging the gas inside the sterilization chamber and reducing the pressure inside the sterilization chamber.

Abstract: A system includes a portable source of gaseous chlorine dioxide (CD). The source has first source and return couplings for sealingly connecting to a CD generation flow path comprising at least one gas conduit. The CD generation flow path comprises second source and return couplings for sealingly connecting the source to a device to be treated with the CD generation flow path, or a tent structure enclosing the device to be treated. A portable scrubber has third couplings for sealingly connecting to a scrubbing flow path comprising at least one gas conduit for removing the CD from the device or tent structure. The gas conduit has fourth couplings for connecting the device or tent structure to the scrubbing flow path.

Abstract: An installation which includes an input station, a sterilization station which includes a sterilization chamber, a desorption station which includes a desorption chamber, and an output station. The installation includes a transporting element which is for transporting multiple objects and which is capable of successively moving the objects from the input station into the sterilization station and into the desorption station as far as the discharge station. The transporting element includes a continuous guiding path, a guide device which is guided by the guiding path. The guided device includes a movement mechanism which is capable of moving the objects between a position for movement along the guiding path and a position for insertion of the objects in the sterilization chamber and the desorption chamber.

Abstract: Multifunctional organic peroxides are used as microbiological inactivators and/or for degrading nucleic acids. These include at least one carbon atom and at least two organic peroxide groups. The inactivator is ideally a hydroperoxide. The invention is particularly useful during preparation of viral vaccines.

Abstract: The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.

Abstract: A method of sterilizing a closed environment is provided in which a disinfection apparatus is placed into the closed environment; it then generates ozone to a predetermined ozone concentration, following which the humidity of the closed environment is rapidly increased. A catalytic converter then reduces the ozone concentration to safe levels. When the ozone concentration is reduced to a predetermined safe level, the disinfection apparatus signals.

Abstract: A system includes a portable source of gaseous chlorine dioxide (CD) to be generated within an isolated chamber or tent structure enclosing the device to be treated. A portable scrubber has first sourced couplings for sealingly connecting to a scrubbing flow path comprising at least one gas conduit for removing the CD from the device enclosed within an isolated chamber or tent structure. The gas conduit may have second couplings for connecting the device or isolated chamber or tent structure to the scrubbing flow path by way of a connection panel to complete a closed, filtered gas loop.

Abstract: A method which enhances a disinfection process by obtaining an additive effect from energy and byproducts of the decomposition process. Also disclosed are contact lens disinfecting systems, wherein the systems are configured to create the desirable elevated pressure, oxygen saturation and sustained peroxide concentration conditions within a contact lens holding and reaction chamber, in order to enhance disinfection by additive effect. The systems are configured to provide that an elevated pressure is maintained in the reaction chamber before venting occurs.

Abstract: The present invention provides with a method of purifying air with significant content of ethylene gas. Bacteria, pathogens, molds, fungus and ethylene gas are removed by using ozone and air filtration technology. This process is useful for storages and production facilities where ethylene might be harmful for perishable products.

Abstract: A free radical decontamination method and system. The system is comprised of a chamber defining a region, and a generator for generating free radical reach effluent from a free radical electric generator and hydrogen peroxide solution with water. A closed loop circulating system is provided for supplying the mixture of free radicals from the electric generator mixed with the hydrogen peroxide solution in the form of the effluent to the chamber.

Abstract: The disclosed invention relates to a decontamination unit that employs a collapsible decontamination enclosure and a decontaminant air stream generator that uses catalytic discharge. The invention also relates to a decontamination process using the decontamination unit. The decontamination unit may be carried by an individual person, for example, in the form of a backpack. The decontamination unit may be ruggedized for use in hostile environments such as those that may be anticipated for military applications.

Abstract: A method of fabricating silicone composite with a layer of antimicrobial coating, the method includes forming an antimicrobial mixture by adding a calculated amount of antimicrobial agent to a solution of water and alcohol, depositing the antimicrobial mixture in a container with a thickness of 0.1 ?m to 10 ?m, evaporating the water and alcohol of the antimicrobial mixture to form the layer of antimicrobial coating, adding silicone resin on top of the layer of antimicrobial coating and allow the silicone resin to permeate and crosslink with the layer of antimicrobial coating and removing the silicone composite with the layer of antimicrobial coating from the container.

Abstract: Aeration drying and disinfecting grain crops in bulk and pretreating seeds includes passing through a bulk of grain crops and seeds disinfecting and drying agents including an ozone and air mixture and surrounding air, subdividing the disinfecting and drying agents into a plurality of streams spaced from one another in a vertical direction, and passing the streams at different heights through levels located at corresponding heights of the bulk of grain crops and seeds transversely in a substantially horizontal direction.

Abstract: There is provided a sterilizing apparatus which is capable of sterilizing articles, such as test tubes, flasks, beakers, scalpels, forceps and so on, with high efficiency in a short time. The sterilizing apparatus includes a sterilizing gas generator 42 that supplies sterilizing gas into a chamber 4. The sterilizing gas generator 42 atomizes a sterilizer solution (oxygenated water) by means of an ultrasonic vibrator 46. The sterilizing apparatus further includes an ultraviolet generator (ultraviolet lamp 50) that irradiates gas in the chamber 4 with an ultraviolet ray. The sterilizing apparatus further includes a door 14 for blocking an opening 2A of the chamber 4 in a free-opening/closing manner and a locking device 52 for prohibiting the door 14 from being opened. The sterilizing apparatus further includes a controller 60 for controlling the locking device 52 to prevent the door 14 from being opened from start of the sterilization process to end of the decomposition process.

Abstract: A method of decontaminating articles, comprising the steps of: (a) moving a plurality of articles having a known temperature along a first path; (b) conveying a carrier gas along a second path that includes an elongated plenum, the second path intersecting the first path downstream from the plenum; (c) heating the carrier gas to a temperature of at least about 105° C. at a location upstream of the plenum; (d) introducing into the carrier gas in the plenum an atomized mist of a liquid hydrogen peroxide of known concentration; and (e) controlling the following: (1) the volumetric flow of carrier gas along the second path; (2) the volume of hydrogen peroxide introduced into the carrier gas; and (3) the temperature of the carrier gas introduced into the plenum, such that the concentration of the vaporized hydrogen peroxide in the carrier gas where the first path intersects the second path has a dew point temperature below the known temperature of the articles.

Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.

Abstract: An exhaust system is provided for exhausting an exhaust gas used for sterilizing an item to be sterilized by using a high concentration NO2 gas, including an ozone generator, a gas treatment means for adsorbing ozone generated by the ozone generator and NO2 in the exhaust gas and accelerating generation of dinitrogen pentoxide or nitric acid by a reaction of the ozone and NO2 to retain the resultant, and an exhaust apparatus for exhausting the exhaust gas. The exhaust system can effectively and ably purify a high concentration NO2 exhaust gas having a concentration beyond the normal level.

Abstract: The present invention provides with a method of purifying air with significant content of ethylene gas. Bacteria, pathogens, molds, fungus and ethylene gas are removed by using ozone and air filtration technology. This process is useful for storages and production facilities where ethylene might be harmful for perishable products.

Abstract: A method which enhances a disinfection process by using a catalyst which increases in effective surface area during the process. Also disclosed are contact lens disinfecting systems which are designed to maintain a high concentration of hydrogen peroxide solution for a longer period of time before increasing the overall surface area of catalyst exposed to the hydrogen peroxide solution. The devices utilize pressure from expanding oxygen generated within the system through use of a small catalyst, or through exposure of only a small portion of a large catalyst, to control deployment of the large catalyst for completing disproportionation of the hydrogen peroxide.

Abstract: A method which enhances a disinfection process by using a catalyst which increases in effective surface area during the process. Also disclosed are contact lens disinfecting systems which are designed to maintain a high concentration of hydrogen peroxide solution for a longer period of time before increasing the overall surface area of catalyst exposed to the hydrogen peroxide solution. The devices utilize pressure from expanding oxygen generated within the system through use of a small catalyst, or through exposure of only a small portion of a large catalyst, to control deployment of the large catalyst for completing disproportionation of the hydrogen peroxide.

Abstract: A device and a method for disinfecting a microtome cryostat with introduction of a disinfection agent (3) into the cryostat chamber (2), action of the disinfection agent on the cryostat chamber, removal of the disinfection agent (3) by precipitation in a colder area (6) and drainage away from there. To enable such a microtome cryostat (1) to be disinfected several times per day without prolonged interruption of operation, a disinfection agent is used (3) that is effective below 0° C. and is introduced as a mist into the cryostat chamber (2) at below 0° C., the disinfection agent (3) being effective as a frost deposit in the cryostat chamber, wherein the frost deposit is displaced into a colder area (6) by sublimation and is converted to liquid by sporadic defrosting phases of this area (6) and thus removed.

Abstract: An electrochemically activated fluid is provided, which has an anolyte and a catholyte. For example, a sparged anolyte and a sparged catholyte are provided. In another example, a combined anolyte and catholyte is provided.

Abstract: A method and apparatus for aerating a region exposed to a gaseous/vaporous sterilant. A catalytic destroyer and a reactive chemical unit are used to reduce the concentration of the gaseous/vaporous sterilant within the region. The reactive chemical unit includes a chemistry that is chemically reactive with the gaseous/vaporous sterilant. In one embodiment, the gaseous/vaporous sterilant is vaporized hydrogen peroxide and the chemistry of the reactive chemical unit includes thiosulfate and iodide.

Abstract: A method and apparatus for aerating a region exposed to a gaseous/vaporous sterilant. A catalytic destroyer and a reactive chemical unit are used to reduce the concentration of the gaseous/vaporous sterilant within the region. The reactive chemical unit includes a chemistry that is chemically reactive with the gaseous/vaporous sterilant. In one embodiment, the gaseous/vaporous sterilant is vaporized hydrogen peroxide and the chemistry of the reactive chemical unit includes thiosulfate and iodide.

Abstract: A method of sanitizing hard and soft goods comprising placing the goods within an a sealable enclosure; sealing the enclosure; producing ozone within the sealed enclosure; circulating the ozone within the sealed enclosure to sanitize the goods; adjusting the environment within the enclosure to optimize the sanitizing properties of and reduce the potential for the ozone to leak to the surrounding environment; removing the ozone to a prescribed safe concentration level; and maintaining the seal of the enclosure until the ozone concentration reaches the prescribed safe concentration level. The enclosure includes an open side; a sealing door for sealing the sealable enclosure; a locking mechanism; a circulation device, a fresh air heater; a vacuum pump, an ozone generator; an ozone destructor, wherein the ozone generator and ozone destructor are disposed within the sealable enclosure; and a humidification device to adjust the relative humidity inside the sealed enclosure.

Abstract: A method of fabricating silicone composite with a layer of antimicrobial coating, the method includes forming an antimicrobial mixture by adding a calculated amount of antimicrobial agent to a solution of water and alcohol, depositing the antimicrobial mixture in a container with a thickness of 0.1 ?m to 10 ?m, evaporating the water and alcohol of the antimicrobial mixture to form the layer of antimicrobial coating, adding silicone resin on top of the layer of antimicrobial coating and allow the silicone resin to permeate and crosslink with the layer of antimicrobial coating and removing the silicone composite with the layer of antimicrobial coating from the container.

Abstract: A method and apparatus for aerating a region exposed to a gaseous/vaporous sterilant. A catalytic destroyer and a reactive chemical unit are used to reduce the concentration of the gaseous/vaporous sterilant within the region. The reactive chemical unit includes a chemistry that is chemically reactive with the gaseous/vaporous sterilant. In one embodiment, the gaseous/vaporous sterilant is vaporized hydrogen peroxide and the chemistry of the reactive chemical unit includes thiosulfate and iodide.

Abstract: A cooking apparatus includes a case in which a cooking chamber for cooking food is provided, a heating source provided in the case, a fan configured to circulate air in the cooking chamber; and a plasma discharger provided in the case and configured to generate plasma in order to remove residue from a surface of the case.

Abstract: This installation comprises an input station (20), a sterilisation station (24) which comprises a sterilisation chamber (90), a desorption station (26) which comprises a desorption chamber (110) and an output station (28). It comprises means (32) which are for transporting the plurality of objects and which are capable of successively moving the plurality of objects from the input station (20) into the sterilisation station (24) and into the desorption station (26) as far as the discharge station (28). The transport means (32) comprise a continuous guiding path (152), a device (154) which is guided by the guiding path (152), the guided device (154) comprising movement means (176) which are capable of moving the plurality of objects between a position for movement along the guiding path (152) and a position for insertion of the plurality of objects in the sterilisation chamber (90) and the desorption chamber (110).

Abstract: An apparatus for sterilizing a sealable enclosure includes a circuit for flow of a sterilizing gas or gasses. The circuit is connected to the enclosure to be sterilized to form a closed circuit and pumps to circulate gas through the circuit and enclosure. The circuit has parallel branches one of which contains apparatus to deactivate a sterilant to be added to the carrier gas flowing through the circuit and apparatus to dehumidify the gas. The other branch contains apparatus to heat the gas and apparatus to supply a sterilant vapor or vapors to the gas. Control apparatus determines which of the parallel branches the gas flows through. The control apparatus maintains flow through one branch passage until the relative humidity falls below a predetermined level. The flow through that branch is then terminated and flow through the other branch initiated.

Abstract: A method and apparatus for aerating a region exposed to a gaseous/vaporous sterilant. A catalytic destroyer and a reactive chemical unit are used to reduce the concentration of the gaseous/vaporous sterilant within the region. The reactive chemical unit includes a chemistry that is chemically reactive with the gaseous/vaporous sterilant. In one embodiment, the gaseous/vaporous sterilant is vaporized hydrogen peroxide and the chemistry of the reactive chemical unit includes thiosulfate and iodide.

Abstract: Disclosed is a plasma treatment module-equipped sterilization apparatus which can easily sterilize thin, long lumens without the aid of boosters. The sterilization apparatus comprises a sterilization chamber, a sterilizing agent feeding line, hydrogen peroxide solution acting as a sterilizing agent, an injection heater, a mass flow controller, a vacuum pump, and an exhaust line. A plasma treatment module is provided on the exhaust line to decompose the hydrogen peroxide vapor exhausted from the sterilization chamber with plasma. Also, disclosed is the sterilization method using the plasma treatment module-equipped sterilization apparatus.

Abstract: A chemical vapor sterilization process is enhanced by concentrating a germicide via condensation and re-vaporization thereof, exploiting the difference between the vapor pressures of the germicide and its solvent to extract some of the solvent during the condensation process.

Abstract: A method which enhances a disinfection process by obtaining an additive effect from energy and byproducts of the decomposition process. Also disclosed are contact lens disinfecting systems, wherein the systems are configured to create the desirable elevated pressure, oxygen saturation and sustained peroxide concentration conditions within a contact lens holding and reaction chamber, in order to enhance disinfection by additive effect. The systems are configured to provide that an elevated pressure is maintained in the reaction chamber before venting occurs.

Abstract: The disclosure relates to an apparatus (10) for decontaminating an enclosure that includes a passage having an inlet (18) to receive a carrier gas from the enclosure, an outlet (31) to discharge the carrier gas to the enclosure, a fan (21) for causing a low of carrier gas through the passage from the inlet to the outlet, and a vapour generator (19) where a decontaminant vapour is introduced into the flow of carrier gas to be discharged with the flow at the outlet to decontaminate the enclosed space. A further fan (33) delivers a separate flow of gas from the enclosure bypassing the passageway in which the decontaminant vapour is introduced to be delivered into the enclosure from outlet vents (32) adjacent the vapour outlets (31) to assist in dispersing the carrier gas containing decontaminant vapour throughout the enclosure.