Abstract: Disclosed are methods for treating platelet compositions (e.g. platelet concentrates and/or platelet lysates) with electron beam radiation, where the compositions are in a frozen state during irradiation with the e-beam radiation. The methods can be conducted using e-beam radiation at doses effective to reduce the pathogen content of the compositions while retaining highly beneficial bioactivities of the compositions. Also disclosed are compositions preparable by the methods, and methods and compositions involving the use of the e-beam treated materials.

Abstract: A method of processing products in a retort having a length includes arranging products in at least one product carrier for movement along at least a portion of the length of the retort and reciprocating the at least one product carrier along at least a portion of the length of retort in a non-sinusoidal pattern of movement.

Abstract: An apparatus and method for sterilization of an article which has a first open end, a second open end and a lumen extending therebetween. The apparatus comprises a first chamber for receiving the article. The first chamber has an outlet fluidly connectable to a pump for adjusting an internal pressure in the first chamber; and an inlet fluidly connectable to a sterilant source for supplying sterilant to the first chamber. The apparatus includes a second chamber fluidly connectable to the first chamber by a chamber connector fluidly sealable to isolate the first and the second chamber; and an article connector for fluidly connecting the second open end of the article to the second chamber to form a fluid path from the first to the second chamber through the lumen. Also included is an article connector for connecting an open end of an article to be sterilized to a sterilization apparatus.

Abstract: A fluid cleaning system for cleaning contaminated water sources via at least one cleaning process. The system includes at least one solids dissociation apparatus that includes a housing, at least one insert operably engaged with the housing and is adapted to receive a continuous fluid stream, and a transducer operably engaged with the housing and is disposed about the at least one insert at a distance away from said at least one insert inside of the housing. The transducer is configured to create cavitation, via sonic waves, to eviscerate contaminants in the continuous fluid stream. The system also includes at least one solids separation apparatus operably connected with the at least one fluid treatment apparatus for receiving the eviscerated contaminants provided in the fluid stream. The at least one solids separation apparatus is adapted to separate the eviscerate contaminants from the fluid stream for at least one separation process.

Abstract: A disinfection chamber for disinfecting probe and probe cord may include a housing, a probe chamber portion defined by the housing, a cord chamber portion defined by the housing, one or more disinfecting portions in operable communication with the probe chamber portion and the cord chamber portion, and a disinfectant composition in operable communication with the one or more disinfecting portions. The one or more disinfecting portions may expel the disinfectant composition within the probe chamber portion and the cord chamber portion to disinfect the probe and at least a portion of the probe cord.

Abstract: There is provided a system and method of cleaning surfaces of an enclosable environment of a contamination comprising a microbial and viral load. The method includes the steps of sealing the enclosable environment and placing water, and a solid or gel pack, into a container and generating a vortex the container by rotating an impeller. The agitation causes the solid or gel pack to release a gaseous cleaning agent. An air-borne spray exiting from the container spreads throughout the enclosable environment to contact the surfaces to be cleaned within the enclosable environment. The enclosable environment is maintained closed for an effective time period while the air-borne spray dwells on the surfaces to eliminate or substantially reduce the load of the contamination.

Abstract: A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP <660>. The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

Abstract: The invention relates to an apparatus for preparing ready-to-use solutions for peritoneal dialysis that has a sterilization compartment; a filling line leading to the sterilization compartment and having a connector arranged at its end at the compartment side for connecting a disposable; a water treatment system arranged in the filling line; and a sealing system. The invention further relates to a disposable for preparing ready-to-use solutions for peritoneal dialysis in such an apparatus and to a method of preparing ready-to-use solutions for peritoneal dialysis using such an apparatus and such a disposable.

Abstract: An applicator for dispensing a solution having two or more components includes a hollow body having a head provided at one end of the hollow body for dispersion of the solution and a breaking mechanism attached to the hollow body. The breaking mechanism includes at least one projection extendable into an interior of the hollow body. The applicator further includes a plurality of ampoules placed in the interior of the hollow body. The plurality of ampoules contains the two or more components. Upon activation of the breaking mechanism, the at least one projection applies a force to the plurality of ampoules such that the plurality of ampoules break and release the two or more components to form the solution.

Abstract: An LED UV sterilization device, including a lens assembly and a light source assembly; the lens assembly includes a plurality of lenses of different materials suitable for light of different wavelengths; the light source assembly includes a visible light source assembly and an ultraviolet light source assembly. Visible light irradiated by the visible light source assembly and invisible ultraviolet light irradiated by the ultraviolet light source assembly pass through lenses of corresponding materials and form an overlapped light spot, so that an irradiation location of the invisible ultraviolet light is indicated by the visible light. The LED UV sterilization device not only realizes safe disinfection and sterilization, but also visualizes the sterilization process. The sterilization process is safer and more reliable, and the sterilization area is more accurate.

Abstract: Disclosed is a system for reducing or eliminating interference during communication. Disclosed is a system to position an implantable medical device at an orientation or position to reduce or eliminate interference. Therefore, a communication may be maintained with the IMD over a selected period of time.

Abstract: Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.

Abstract: A method of cleaning and sterilizing a drink filling apparatus that includes drink supply piping that feeds a drink sterilized in a heating sterilization part into a filling machine includes performing a cleaning in place (CIP), in which a cleaner is circulated in the drink supply piping to remove a drink residue or the like on an interior of the drink supply piping, raising a temperature of the cleaner to a temperature required for a sterilizing in place (SIP), which is performed in succession to the CIP to sterilize the interior of the drink supply piping, from an early stage or middle stage of the CIP, then performing the SIP for the interior of the drink supply piping, and washing the cleaner away with aseptic water heated and sterilized in the heating sterilization part.

Abstract: A method of cleaning and sterilizing a drink filling apparatus including a CIP process of circulating a cleaner in a drink supply piping to remove foreign matter on an interior of the drink supply piping, and an SIP process of sterilizing the interior of the drink supply piping. The processes are performed at the same time or in sequence without an interruption between the two. The SIP process uses the cleaner to sterilize the interior of the drink supply piping. After the SIP process, while the cleaner is kept circulating, a temperature condition at a predetermined position in the drink supply piping is adjusted to a temperature setting for manufacture, after which the cleaner in the drink supply piping is removed.

Abstract: A method for targeted delivery of cargo to a target locus in a subject and components of the system. Generally, the method includes administering to the subject a cell that has an artificial saccharide-derived target presented on the surface of the cell, allowing the cell to localize to a target locus in the subject, then administering to the subject an agent that specifically binds to the artificial target. In some embodiments, the agent can include a therapeutic compound. In some embodiments, the agent can include a detectable label. In some of these embodiments, that method can further include detecting the detectable label.

Abstract: The invention provides an aroma device for self-generating water vapor. The aroma device comprises a water vapor generator and an aroma body bearing portion. The water vapor generator is internally provided with a self-heating bag that is chemically reacted with water to generate high-temperature water vapor. Generated water vapor with aroma escapes outwards through an aroma carrier. The aroma device is convenient to carry and wide in diffusion range without a power supply. The high-temperature water vapor directly gasifies essence in a medium without generating other harmful dust and smog, and the aroma effect is remarkably enhanced.

Abstract: The subject matter of the invention is a therapeutic device in the form of a cylindrical chamber which comprises a hyperbaric chamber, LED matrices (5) and inductive coil rings (10, 11, 12, 13), constructed in one inseparable set in the form of a chamber of 200-280 cm in length and diameter of the round cylinder (70-130 cm).

Abstract: A surgical instrument comprises a handle assembly including an actuator mounted for manipulation through an actuation stroke. An elongate shaft extends distally from the handle assembly and defines a longitudinal axis. A reciprocating member extends at least partially through the elongate shaft, and is mounted for longitudinal motion through the elongate shaft in response to manipulation of the actuator through the actuation stroke. A drive mechanism includes a first rotating component coupled to the actuator about a first circumference to induce rotational motion in the first rotating component. A second rotating component is coupled to the first rotating component such that rotational motion in the first rotating component induces rotational motion in the second rotating component. The second rotating component is coupled to the reciprocating member about a second circumference such that rotational motion of the second rotating component induces longitudinal motion in the reciprocating member.

Abstract: This disclosure describes substrate(s) formed with a three-dimensional (3D) feature thereon, and method(s) of printing the same. One method includes identifying a plurality of locations on a substrate surface where the three-dimensional feature will be formed, determining a height value of the three-dimensional feature at each location, assigning a grayscale value to each location based on the height value, and applying ink to the substrate surface at each location according to the assigned grayscale value.

Abstract: Ozone-based methods and systems for treatment of solid waste that contains pathogens, and requires apparent volume reduction, include using dual treatment chambers, lift transporters that cascade the preliminarily treated solid waste, and agitation within the second (high ozone concentration) treatment chamber. The steps include feeding solid waste into a shredder chamber to reduce its apparent volume; and then to a first treatment chamber for preliminary ozone molecular interaction with the solid waste, and to a second treatment chamber with an agitator, via at least one lift transporter, to both cascade and agitate to enhance efficacy.

Abstract: The invention relates to a facility which has a dirty facility area and an adjacent clean facility area, baskets for receiving the dirty articles, and a wall separating the dirty area from the clean area, the dirty area including an entry door for receiving the dirty articles, pre-processing stations with tables for the pre-washing and/or sorting by a human operator, or even by a robotic operator, of the dirty articles and for arranging the pre-washed and/or sorted articles in the baskets, pick-up points at the pre-processing stations for pick-up of the baskets with the pre-washed and/or sorted articles, a plurality of washers, eg.

Abstract: Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture.

Abstract: A method of treatment with at least one biocidal and/or safener product with a boiling temperature between 60 and 280° C., wherein the method comprises a treatment step duration greater than or equal to 3 days, wherein the treatment step comprises at least one injection phase of a duration greater than or equal to 3 days during which a liquid containing the, or each, product is evaporated and injected inside an enclosure, wherein the liquid is evaporated and injected with a period of less than or equal to two days during the injection phase, wherein the liquid is evaporated at a temperature below 50° C.

Abstract: A disinfectant device includes a housing, a UV source disposed within the housing, a reflector for directing rays from the UV source downward through a bottom of the housing, a motion detector, a frequency detector, and an indicator light, said UV source specific to a non-visible light spectrum in a range of 200 nm to 222 nm. The bottom can be an open bottom or may include a glass covering. A timer can be included to display a duration for the UV source to be turned on. The device can include a protective curtain about a perimeter of the bottom of the housing. The reflector can be ellipsoidal in shape to direct the rays from the UV source downward through the bottom of the housing.

Abstract: Devices having user-interactive guided control interfaces. The devices are for washing, disinfecting and/or sterilizing medical, dental, laboratory and/or pharmaceutical goods. Devices may include sterilizers, washer-disinfectors, autoclaves, and washers. Users are only presented with user interface objects which are appropriate at each step or process state of the guided process. Devices may include a touch screen, a chamber for goods to be processed, and a door to the chamber. Different sets of user interface objects are presented on a display for different respective states of the device.

Abstract: Provided herein are portable ultraviolet (UV) devices, systems, and methods of use and manufacturing same. Methods of use include methods for UV disinfection and sterilization, more specifically, methods for UV disinfection and sterilization of a container, a room, a space or a defined environment. The portable UV devices, systems and methods are particularly useful for the UV disinfection and sterilization of a container, a room, a space or defined environment used in various industries. Provided are also portable UV devices, systems, and methods for inhibiting the growth of one or more species of microorganisms present in a container, a room, a space or a defined environment, preferably for inhibiting the growth of one or more species of microorganisms present on an interior surface of a container, a room, a space or a defined environment.

Abstract: A system for producing biomass pellets comprising a pan mill for comminuting a biomass material, a treatment means in which the comminuted biomass material is treated with an oxidizing reactant and a pellet press for pressing pellets from the treated biomass material. The invention further relates to an associated process. The intention is to initiate during pellet production oxidation reactions which can otherwise result in autoignition of the pellets in pellet heaps.

Abstract: A treatment apparatus and method of treating an inside volume of a mobile vehicle using the apparatus. The method includes the steps of: a) placing a treatment unit in an operative position with respect to the mobile vehicle, the treatment unit having: i) a frame; ii) a source of UV light; and iii) an air mover for controllably directing air within the inside volume to be exposed to UV rays generated by the UV light source; and b) operating the treatment unit and thereby causing air within the inside volume to be disinfected by UV light rays from the UV light source and circulated within the inside volume.

Abstract: Systems and methods of producing a solid fuel composition are disclosed. In particular, systems and methods for producing a solid fuel composition by heating and mixing a solid waste mixture below atmospheric pressure to a maximum temperature sufficient to melt the mixed plastics within the solid waste mixture is disclosed.

Abstract: The invention relates to a facility which has a dirty facility area and an adjacent clean facility area, baskets for receiving the dirty articles, and a wall separating the dirty area from the clean area, the dirty area including an entry door for receiving the dirty articles, pre-processing stations with tables for the pre-washing and/or sorting by a human operator, or even by a robotic operator, of the dirty articles and for arranging the pre-washed and/or sorted articles in the baskets, pick-up points at the pre-processing stations for pick-up of the baskets with the pre-washed and/or sorted articles, a plurality of washers, eg.

Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.

Abstract: Disinfection apparatus having submersible disinfection devices for disinfecting fluid. The disinfection apparatus includes: a pipe having one or more linear segments; one or more disinfection devices installed on the pipe, each of the one or more disinfection devices generating light for disinfecting fluid in a linear segment of the pipe; and a controller electrically coupled to the one or more disinfection devices and controlling the one or more disinfection devices. Another embodiment of the disinfecting apparatus includes; side and bottom walls and a lid that define an enclosed chamber; an inlet and outlet for communicating fluid to the enclosed chamber; a plurality of disinfection devices disposed on the side wall, each of the plurality of disinfection devices generating light for disinfecting fluid inside the enclosed chamber; and a controller electrically coupled to the plurality of disinfection devices and controlling the plurality of disinfection devices.

Abstract: A cleansing and packaging system for pipeline preparation of specialty medical instruments and method for cleansing and packaging instruments are provided herein. The cleansing and packaging system includes a first sealable cleansing compartment and a second sealable packaging compartment. A conveyor device transports medical instruments to be cleansed through a sealing entry door to the cleansing compartment, then to the packaging compartment through a sealing joining door, and then out of the packaging compartment through a sealing exit door. The cleansing compartment includes a sanitation system and a sterilization system, each which includes its own inspection devices that operate continuously to confirm the success of sanitation and sterilization operations. The packaging compartment includes a packaging system, which may include its own inspection devices that operate continuously to confirm the quality of the packaging of medical instruments.

Abstract: Provided herein are portable ultraviolet (UV) devices, systems, and methods of use and manufacturing same. Methods of use include methods for UV disinfection and sterilization, more specifically, methods for UV disinfection and sterilization of a container, a room, a space or a defined environment. The portable UV devices, systems and methods are particularly useful for the UV disinfection and sterilization of a container, a room, a space or defined environment used in the food, beverage and dairy industry and in the process of fermentation for an alcoholic beverage. Provided are also portable UV devices, systems, and methods for inhibiting the growth of one or more species of microorganisms present in a container, a room, a space or a defined environment, preferably for inhibiting the growth of one or more species of microorganisms present on an interior surface of a container, a room, a space or a defined environment.

Abstract: A communication hub provides communication between a number of medical device processing components within a network. A user may access the communication hub via a user device such as a smartphone or computer and monitor and manage configurations and information relating to the medical device processing components. Features include the ability to view current status of medical device processing components in order to identify a device that is available for current use, to receive notifications of failed or completed tasks on devices, to disable or enable devices remotely, to view statistics and data visualizations of the performance and use of devices, and other similar features.

Abstract: The present invention relates to novel compounds and their use as malodor counteractant materials.

Abstract: The present invention relates to a method for sterilizing a chromatography material, more particularly microporous polymer membranes, to a chromatography material which has been sterilized by the method according to the invention, to the use of the chromatography material sterilized according to the invention for the chromatographic removal of contaminants from a fluid, and to a closed chromatographic filtration system comprising a chromatography material sterilized according to the invention.

Abstract: A pulsed UV disinfection system includes a xenon UV lamp mounted in an articulated head assembly and a chassis housing a high voltage power supply for driving the lamp and a pulse configuration control unit for configuring the output of the power supply. The head assembly and the chassis are positioned on a mobile carriage. The pulse configuration control unit is programmed for driving the UV lamp at a rate of between 20 and 50 pulses per second, with each pulse emitting between 30 and 150 joules of UV radiant energy. The system also features remote video imaging of a target area, remote control of the carriage and head assembly as well as a remote emergency shutdown.

Abstract: Provided is a system for supplying a liquid (such as an irritative chemical solution) safely. This liquid supplying system comprises: (a) a means that creates a negative pressure in a treatment chamber by driving a first depressurizing means and depressurizing the treatment chamber; (b) a means that introduces the negative pressure of the treatment chamber to a measurement chamber; (c) a means that maintains the negative pressure introduced to the measurement chamber; (d) a means that sucks a liquid from a container into the measurement chamber by employing the negative pressure of the measurement chamber; and (e) a means that sucks the liquid of the measurement chamber into the treatment chamber by employing a vacuum in the treatment chamber.

Abstract: A cleaning device includes a flushing chamber having opposite proximal and distal ends, and a length extending between the proximal and distal ends. An inlet port of the cleaning device is in fluid communication with the flushing chamber and configured for fluid connection to a source of fluid. The flushing chamber is selectively openable along its length to an open position, in which the distal end portion of the medical instrument is insertable into the flushing chamber, and selectively closable along its length to a closed position, in which the distal end portion of the medical instrument is enclosed and fluidly sealed within the flushing chamber.

Abstract: A virus inactivation and sampling apparatus for use in a process of purifying a liquid drug substance. A closed circulation line is formed by an outlet port 11 of a bag 10 containing a liquid drug substance, a first line 41, sampling means 20, a second line 42 (pH meter 30) and an inlet port 12 of the bag 10, and an acidic aqueous solution is fed through an acidic aqueous solution line 45 and circulated to inactivate viruses in the liquid drug substance.

Abstract: A method and apparatus for disinfecting a lavatory inside a vehicle in response to a set of criteria being met. A determination is made as to whether a set of criteria for activation of a disinfection system that emits far-ultraviolet radiation to perform a disinfection process inside a lavatory has been met. In response to a determination that the set of criteria has been met, the disinfection system is activated to perform the disinfection process inside the lavatory using the far-ultraviolet radiation.

Abstract: The invention provides an air purifier (1) comprising a catalytic converter (100), the catalytic converter (100) comprising (i) a catalytically active material (120) and (ii) a heatable material (130) in thermal contact with said catalytically active material (120), wherein the heatable material (130) is heatable by one or more of an alternating electrical field and an alternating magnetic field, the air purifier (1) further comprising a field generator (140), configured free from electrical contact with the heatable material (130) and configured to heat during operation of the air purifier (1) the heatable material (130) by one or more of the alternating electrical field and the alternating magnetic field.

Abstract: A ventilation system comprising a conveying unit for conveying a supply airstream into an interior space through at least one air outlet channel, and at least one exhaust air opening which may have an adjustable opening width. The at least one air outlet channel arranged at a distance from the at least one exhaust air opening, such that an airstream is established during operation therebetween in the interior space. The ventilation system is paired with a humidifying device to supply humidity into the interior space, said humidifying device comprising a generator for generating an aerosol from a liquid with droplets sized to be carried by the airstream, and at least one aerosol outlet channel arranged in the interior space such that the aerosol is captured by the airstream. A method for conditioning an interior space using at least one or more such ventilation systems is further described.

Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

Abstract: The present disclosure relates to methods and systems for processing isolated mammalian tissue for use in surgical grafting, implantation, or transplantation procedures. The method employs electron beam sterilization, the collagen tissue is partially submerged in rHSA (Recombinant Human Serum Albumin), the tissue is stored in specially designed packaging, and the tissue is stored at ambient temperatures without requiring refrigeration. The terminal sterilization using electronic beams takes place in the special packaging. This inventive technology offers advantages including being biologically safe, maintaining tissue integrity while minimizing size, increasing scalability, increasing shelf life, increasing the amount of tissue usable for transplantation, and reducing of costs associated with processing and storing tissue for long periods of time.

Abstract: A system for decontamination of a medical device comprising a decontamination chamber configured to withstand pressure changes; a vacuum pump configured to adjust the pressure within the decontamination chamber; and a source of decontaminating substance positioned within the decontamination chamber. The system also includes a container within the decontamination chamber to enclose a medical device and provide fluid communication between the medical device and the source of decontaminating substance; and a vaporizer positioned within the decontamination chamber to vaporize the decontaminating substance.

Abstract: The present invention relates to a solid pressed air freshener and odor neutralizer composition which can include greater than 10% fragrance. The air freshener comprises a fragrance; preferably the fragrance is impregnated within a water soluble substrate made from a foamed vegetable starch, a surfactant and a solidifier. The solid formulations break down easily in the presence of water and may be sprayed, within the area to be freshened.

Abstract: An electrospinning approach is disclosed for generating a dissolvable formulation of a reagent of interest in a nanoscale fiber medium. In one embodiment, the nanoscale fibers can incorporate and stabilize biological agents of interest, such as for storage at room temperature for extended periods. In one implementation, the fibers can be produced in a continuous manner and dissolve rapidly.

Abstract: Methods and delivery systems for providing a gas phase of a multi-component liquid source for delivery to a critical process application are provided. The methods include concentration of a component of the liquid source which is less volatile than water for delivery of a gas stream comprising the less volatile component to a critical process application. Critical process applications include decontamination and microelectronic processing applications.