By Sudden Release Of Pressure Patents (Class 422/39)
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Patent number: 11779666Abstract: A continuous differential-pressure steam sterilization system for a powder, and belongs to the field of material sterilization includes: a superheated steam generation system, a steam pressure and flow rate control system, a quantitative feeding system, an instantaneous differential-pressure sterilization system, a dust explosion suppression system, a sterile cooling system, a primary gas-solid separation system, a secondary gas-solid separation system, a sterile storage system, a steam recovery and reheating system, and a condensate recovery system. The continuous differential-pressure steam sterilization system shortens the thermal contact time and mainly accumulates the heat on the surface of the powder, rather than in the center of the powder, which reduces the damage to the nutritional quality of the powder.Type: GrantFiled: March 22, 2023Date of Patent: October 10, 2023Assignee: INSTITUTE OF FOOD SCIENCE AND TECHNOLOGY, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Fengzhong Wang, Litao Tong, Zhiying Chen, Bei Fan, Lili Wang, Long Li
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Patent number: 9060926Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: October 31, 2008Date of Patent: June 23, 2015Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Patent number: 8709263Abstract: A method of removing contaminants from slurry samples is set forth. The method includes the utilization of repeated pressurizing and depressurizing steps to disrupt solidified particles in solid-containing slurries thereby increasing decontamination efficiency. An expansion fluid is injected into the slurry sample sufficient to create microbubbles when the slurry sample is depressurized. The micro bubbles mechanically disrupt the solidified particles increasing contaminant exposure. The microbubbles also provide for increased interfacial regions where contaminants can accumulate at gas-liquid thin films that are in close proximity to and can be effectively removed using a suitable expansion fluid and optional decontamination agents.Type: GrantFiled: April 11, 2007Date of Patent: April 29, 2014Assignee: University of Utah Research FoundationInventor: P. K. Andy Hong
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Publication number: 20140065187Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.Type: ApplicationFiled: August 30, 2013Publication date: March 6, 2014Applicants: TOP INDUSTRIE S.A.S., MERIAL LIMITEDInventors: Nicolas Pierre Yves Carboulec, Gildas Merian, Rene Labatut, Lionel Gerentes
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Patent number: 8663556Abstract: [Problem to be solved] To provide a method for sterilizing powder or grain by which the heating time is a minimum required time to reduce thermal degradation of the quality of the powder or grain while securing sufficient sterilization effect, and a sterilizing apparatus employing the method. [Means to solve the problem] The problem is solved by a method for sterilizing powder or grain, and a sterilizing apparatus employing the method, and the method includes applying heat and pressure in which powder or grain is supplied into a heated gas flow pipe kept under heated and pressurized conditions, and the powder or grain is transferred while coming into direct contact with a heated condensable gas in the heated gas flow pipe for 0.Type: GrantFiled: May 26, 2009Date of Patent: March 4, 2014Assignee: Fujiwara Techno-Art Co., Ltd.Inventors: Masahiro Kariyama, Toshio Hirata, Fumihiro Sato, Akira Mori, Hidehi Takebe
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High-pressure sterilization to terminally sterilize pharmaceutical preparations and medical products
Patent number: 8617467Abstract: The present invention provides a process for sterilizing a system, preferably a pharmaceutical preparation such as a dispersion of small particles or droplets of a pharmaceutically active compound using high pressure terminal sterilization techniques and products therefrom.Type: GrantFiled: September 22, 2004Date of Patent: December 31, 2013Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Alfredo Rodriguez, Barrett E. Rabinow, Mark Doty, Jamie Konkel -
Publication number: 20130302211Abstract: A method and device related to a liquid product pressure and (optionally) temperature treatment method reduces the level of microorganisms in the liquid product to a preselected level. Utilizing the method, liquid product is diffused in a chamber with the speed of pressure variation of liquid product in one embodiment of about 109 Pa/sec. The preferred speed of the diffused drops is about 10 m/sec. The liquid product can optionally be heated before or during diffusion, and is preferably heated as a diffused liquid product by mixing it with superheated steam.Type: ApplicationFiled: March 14, 2013Publication date: November 14, 2013Inventors: Andrei Alexandrovich Volkov, Nikolay Vladislavovich Arofikin, Alexander Yurievich Kolesnov
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Patent number: 8465652Abstract: The invention relates to a technique of disinfecting household and industrial waste water used as the basis of organo-mineral fertilizers. The present method of disinfection is carried out by means of quick vacuum-pulse actions on sewage sludge using a receiver and quick response valves, with a pulse duration of less than 1.0 seconds at a pressure of not more than 20 mmHg to achieve the required degree of disinfection. Technical result of the use of the invention is to accelerate and simplify the process of disinfection method.Type: GrantFiled: December 16, 2010Date of Patent: June 18, 2013Assignee: Twin Trading CompanyInventors: Yakov Kuzmich Abramov, Vladimir Mihailovich Veselov, Viktor Mihailovich Zalevsky, Vitaly Grigorevich Tamurka, Nikolay Dmitrievich Argunov, Ljubov′ Viktorovna Motovilova, Nikolay Vladimirovich Dvoryaninov, Lidija Petrovna Bogdanova
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Patent number: 8449820Abstract: A method and device related to a liquid product pressure and (optionally) temperature treatment method reduces the level of microorganisms in the liquid product to a preselected level. Utilizing the method, liquid product is diffused in a chamber with the speed of pressure variation of liquid product in one embodiment of about 109 Pa/sec. The preferred speed of the diffused drops is about 10 m/sec. The liquid product can optionally be heated before or during diffusion, and is preferably heated as a diffused liquid product by mixing it with superheated steam. The device includes a chamber and a diffuser in communication with the chamber.Type: GrantFiled: May 3, 2010Date of Patent: May 28, 2013Assignee: Millisecond Technologies Corp.Inventors: Andrei Alexandrovich Volkov, Nikolay Vladislavovich Arofikin, Alexander Yurievich Kolesnov
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Patent number: 8241576Abstract: A process and apparatus wherein multiple instantaneous pressure pulsations with a regulated frequency and amplitude are applied to various biological substances in order to eliminate the undesired microorganisms in these substances with minimal negative effect on the quality of these substances, and, further, to use these in mass production of foodstuffs pharmaceuticals for treatment of human blood or plasma, and for research to establish a specific frequency of pressure pulsations at which a particular type of bacteria could be selectively destroyed while other components of the substance remain intact.Type: GrantFiled: July 13, 2007Date of Patent: August 14, 2012Inventor: Oleg Rozenberg
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Patent number: 8088938Abstract: Methods of storing a precursor which decreases the precursor decomposition rate. A vessel is provided, where the vessel has an outer surface made of a first material, and an inner surface made of a second material. The first and second materials are different. A tantalum containing precursor is placed inside the vessel, and the vessel is heated to a temperature between 60° C. and 150° C. At least part of the precursor is withdrawn from the vessel.Type: GrantFiled: December 22, 2008Date of Patent: January 3, 2012Assignees: Air Liquide Electronics U.S. LP, American Air Liquide, Inc.Inventors: Nathan Stafford, Christian Dussarrat, Olivier Letessier, Ravi K. Laxman
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Publication number: 20110104006Abstract: [Problem to be solved] To provide a method for sterilizing powder or grain by which the heating time is a minimum required time to reduce thermal degradation of the quality of the powder or grain while securing sufficient sterilization effect, and a sterilizing apparatus employing the method. [Means to solve the problem] The problem is solved by a method for sterilizing powder or grain, and a sterilizing apparatus employing the method, and the method includes applying heat and pressure in which powder or grain is supplied into a heated gas flow pipe kept under heated and pressurized conditions, and the powder or grain is transferred while coming into direct contact with a heated condensable gas in the heated gas flow pipe for 0.Type: ApplicationFiled: May 26, 2009Publication date: May 5, 2011Applicant: FUJIWARA TECHNO-ART CO., LTD.Inventors: Masahiro Kariyama, Toshio Hirata, Fumihiro Sato, Akira Mori, Hidehi Takebe
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Publication number: 20110064611Abstract: Shock waves are applied to clean and sterilize fluids in containers and conveyances. Shock waves destroy pathogens and pollutants in blood, water, food liquids and other fluids.Type: ApplicationFiled: September 17, 2010Publication date: March 17, 2011Inventors: Iulian Cioanta, Yannick Spenninck
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Publication number: 20100322821Abstract: A method and device related to a liquid product pressure and (optionally) temperature treatment method reduces the level of microorganisms in the liquid product to a preselected level. Utilizing the method, liquid product is diffused in a chamber with the speed of pressure variation of liquid product in one embodiment of about 109 Pa/sec. The preferred speed of the diffused drops is about 10 m/sec. The liquid product can optionally be heated before or during diffusion, and is preferably heated as a diffused liquid product by mixing it with superheated steam. The device includes a chamber and a diffuser in communication with the chamber.Type: ApplicationFiled: May 3, 2010Publication date: December 23, 2010Inventors: Andrie Alexandrovich Volkov, Nikolay Vladislavovich Arofikin, Alexander Yurievich Kolesnov
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Patent number: 7815810Abstract: The invention disclosed provides an apparatus and method for disinfection of ship's ballast water, such as sea water, based on hydrodynamic cavitation. The apparatus comprises a cavitating chamber of cross section such as circular or non circular shape housing a single or multiple cavitating element(s) in the form of plates of metallic, ceramic, plastic materials of varying thicknesses placed perpendicular to the direction of flow of liquid and positioned at uniform or non-uniform spacing. The cavitating elements are provided with single or multiple orifices of different cross sections, circular or non-circular, with or without sharp edges and with a fraction of cross-sectional open area of the passage. The disinfected water may be re-circulated through the system for additional disinfection or released from the tank into the surrounding waterways.Type: GrantFiled: March 15, 2006Date of Patent: October 19, 2010Assignees: Council of Scientific and Industrial Research, Mumbai University Institute of Chemical TechnologyInventors: Pandit A. Bhalchandra, Ranade V. Vinayak, Anil A. Chandrashekar, Sawant S. Shivram, Ilangovan Dandayudapani, Madhan Rajachandran, Pilarisetty V. Krishnamurthy
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Publication number: 20100221147Abstract: An aqueous solution of electrolytes, a sugar osmotic agent and a physiologically safe salt of a reductive sulfur oxy-acid. Alternatively, the dialysate comprises an aqueous solution of electrolytes, a salt of a reductive sulfur oxy-acid, and osmotic agents which contain an oncotic agent other than a sugar osmotic agent.Type: ApplicationFiled: May 11, 2010Publication date: September 2, 2010Inventors: Asahi Sakai, Masaaki Nakayama
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Patent number: 7718119Abstract: An apparatus and method for generating a desired smell by processing smell information through a combination of a computer system and a perfume generating means. In order to generate a desired smell under control of a computer, preset perfume information concerning a smell classification table, kinds of preset perfume corresponding to the items of smell in the smell classification table, the amount of smell to be generated and the variation with time of the amount is registered, the item of a specific smell is selected from the smell classification table, and relevant pieces of the preset perfume information corresponding to the item of the specific smell is extracted. A deodorant may be combined or various smells may be combined with an image.Type: GrantFiled: May 28, 2001Date of Patent: May 18, 2010Inventors: Yukinobu Tajima, Hideki Tanemura, Naoki Urushihata
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Patent number: 7708941Abstract: A method and device related to a liquid product pressure and (optionally) temperature treatment method reduces the level of microorganisms in the liquid product to a preselected level. Utilizing the method, liquid product is diffused in a chamber with the speed of pressure variation of liquid product in one embodiment of about 109 Pa/sec. The preferred speed of the diffused drops is about 10 m/sec. The liquid product can optionally be heated before or during diffusion, and is preferably heated as a diffused liquid product by mixing it with superheated steam. The device includes a chamber and a diffuser in communication with the chamber.Type: GrantFiled: June 22, 2007Date of Patent: May 4, 2010Assignee: Millisecond Technologies Corp.Inventor: Nikolay Vladislavovich Arofikin
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Publication number: 20080292494Abstract: A method for reducing biological and/or chemical contaminants within a feed fluid stream includes in one embodiment the following steps: a) introducing the fluid stream into a cold pass of at least one recuperator; b) optionally heating the feed fluid stream using a heater; and c) introducing the feed fluid stream into a compressor, and compressing the fluid stream to an elevated pressure, resulting in heating of the fluid stream to an elevated temperature, thereby producing a decontaminated fluid stream.Type: ApplicationFiled: May 16, 2008Publication date: November 27, 2008Inventors: James F. Garvey, John A. Lordi, James Wulf
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Publication number: 20080014114Abstract: The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation.Type: ApplicationFiled: July 13, 2006Publication date: January 17, 2008Inventors: Reuel Van Atta, Dias Lourenco Francisco
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Patent number: 7189350Abstract: A pressure cleaning vessel is connected to a vacuum chamber by way of a connecting pipe in the sterilizing and cleaning equipment that utilizes a supercritical fluid. The objects to be treated are impregnated, for a given period, in the supercritical fluid with which the pressure cleaning vessel has been filled. Thereafter, the connection between the pressure vessel and the vacuum chamber is opened so as to generate sudden bubbling within the vessel as a result of a large pressure difference. Thorough sterilization is achieved at the time when the supercritical fluid having penetrated into bacteria and viruses suddenly explodes and destroys these organisms instantly by vaporization and expansion.Type: GrantFiled: September 3, 2003Date of Patent: March 13, 2007Assignee: Kabushiki Kaisha SR KaihatsuInventor: Masayuki Kanno
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Patent number: 6939444Abstract: A sulfur-bearing residue treatment system is provided for the recovery of valuable organic components and the reduction of capital costs and operating costs. The treatment system involves the use of a stripping vessel in conjunction with a heating apparatus. All elements of the treatment system may be coupled together to form one integral piece of equipment.Type: GrantFiled: June 7, 2002Date of Patent: September 6, 2005Assignee: Rohm and Haas CompanyInventors: Curtis Instad Carlson, Jr., Michael Stanley DeCourcy, Jamie Jerrick John Juliette, Thomas Albert Kaminski, Nicole Rendon Koegel, Nelson Ivan Quiros, Paul Benjamin Schladenhauffen, Peter John Schmeidler, Robert R. Maven, William Harry Engle, Jr., Arthur Meisch
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Patent number: 6939510Abstract: The present invention provides a sustained-releasing anti-protista preparation, including using a water-insoluble or difficulty water soluble and water-wettable polymer compound which is solid at room temperature as a sustained-releasing substrate material, a method for a preparation of the sustained-releasing anti-protista preparation, including kneading a water-insoluble or difficulty water soluble and water-wettable polymer compound which is solid at room temperature with an anti-protista substrate, and a sustained-releasing anti-protista preparation for a waterway, including using a water insoluble or difficulty water soluble and water-wettable polymer compound which is solid at room temperature as a sustained-releasing substrate material.Type: GrantFiled: April 23, 2001Date of Patent: September 6, 2005Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Hiroyuki Kato, Tadayoshi Yazaki, Tokihiko Maruyama
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Patent number: 6824751Abstract: A device for cleaning and sterilizing the inside of a chamber, including a supply of sterilizing liquid for said chamber and a device for inducing variations in the pressure, amplitude, frequency and the gradient of said variations in the sterilizing liquid, whereby said device is adapted in such a way that cavitation occurs inside the liquid, the device inducing said pressure variations include a liquid column between the chamber and a switching organ, whereby the chamber can be cyclically connected to a depression, whereby the value thereof is related to the amplitude or respectively to the atmospheric pressure.Type: GrantFiled: August 2, 2001Date of Patent: November 30, 2004Assignee: Meditecnic Inc.Inventor: Jordi Rossell
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Publication number: 20040234437Abstract: Apparatus for the treatment of material comprises a confined volume for receiving the material, and a source of gas at elevated pressure communicable with the interior of the volume. A suitable source of gas is an airgun, or other apparatus capable of releasing a volume of gas at elevated pressure such as at least 1000 psi. It is preferred that the source of gas is located within the confined volume. It is also preferred that the confined volume is a pressure vessel. Inlet an outlet valves will assist in loading and unloading material for treatment. Gate valves will further assist by closing when the volume is full. The invention is thus particularly useful in the destruction of chemical and biological agents, for the purification of contaminated water, and for the destruction of tropical and other larvae previously leading to diseases such as Nile Disease, malaria and the like.Type: ApplicationFiled: December 23, 2003Publication date: November 25, 2004Applicant: Flute Developments LimitedInventor: Alan Colin McGowan
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Publication number: 20040151620Abstract: The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about −40° C. to about 95° C., or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.Type: ApplicationFiled: February 2, 2004Publication date: August 5, 2004Applicant: BBI BioSeq, Inc., a Massachusetts corporationInventors: James A. Laugharn, David W. Bradley, Robert A. Hess
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Patent number: 6767568Abstract: A method and apparatus for processing meat is provided. According to the method, a meat product is positioned within an interior volume of a decompression chamber. A pressure differential is created across a gas output in communication with the interior volume of the decompression chamber. The decompression chamber is then rapidly decompressed by transferring gas from the interior volume of the decompression chamber through the gas output. The pressure differential and the rate of the rapid decompression are selected to be suitable for processing the meat product positioned within the interior volume of the decompression chamber. Typically, the pressure differential and the rate of rapid decompression are selected to be suitable for tenderizing the meat product, killing microorganisms in the meat product, or both.Type: GrantFiled: May 25, 2001Date of Patent: July 27, 2004Assignee: Spectra Research, Inc.Inventors: Stanley Eugene Tate, John William Sellers, Jr., Morse Bartt Solomon, Bradford William Berry
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Publication number: 20040120852Abstract: A pressure cleaning vessel 1 is connected to a vacuum chamber P by way of a connecting pipe in the sterilizing and cleaning equipment which utilizes a supercritical fluid. The objects to be treated is impregnated, for a given period, in the supercritical fluid with which the pressure cleaning vessel 1 has been filled. Thereafter, the connection between the pressure vessel 1 and the vacuum chamber P is opened so as to generate sudden bubbling within the vessel 1 as a result of a large pressure difference. Thorough sterilization is achieved at the time when the supercritical fluid having penetrated into bacteria and viruses suddenly explodes and destroys these organisms instantly by its power of vaporization and expansion.Type: ApplicationFiled: September 3, 2003Publication date: June 24, 2004Applicant: KABUSHIKI KAISHA SR KAIHATSUInventor: Masayuki Kanno
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Patent number: 6749809Abstract: A clustered creature exterminating method efficiently exterminates clustered creature such as cyanobacteria in large quantity with use of a pressure which is substantially lower than that of the conventional method. The exterminating method includes the steps of: pressurizing a fluid containing a clustered creature such as cyanobacteria through a pump; suddenly lowering the pressure applied to the fluid by injecting the fluid from nozzle groups; and destroying a bonding in the clustered creature by a cavitation caused by the pressure drop. The nozzle groups may be arranged to oppose to one another to collide the injected fluids with each other, which divides the cyanobacteria into many small pieces. As a result, the cyanobacteria lose the ability to rise, and sink at the bottom of water, therefore, die because they cannot photosynthesize.Type: GrantFiled: September 17, 2001Date of Patent: June 15, 2004Assignee: Karasawa Fine, Ltd.Inventor: Yukihiko Karasawa
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Patent number: 6696019Abstract: The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about −40° C. to about 95° C., or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.Type: GrantFiled: August 7, 2001Date of Patent: February 24, 2004Assignee: BBI BioSeq, Inc.Inventors: James A. Laugharn, Jr., David W. Bradley, Robert A. Hess
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Patent number: 6673311Abstract: A method for continuous heat sterilization of liquid includes a continuous pre-heating step of preheating the liquid, a final heating step of heating the preheated liquid to reach a predetermined sterilizing temperature, a holding step of holding the liquid which has reached the predetermined sterilizing temperature for a predetermined period of time, and a cooling step of cooling the held liquid. The final heating step comprises the following steps (a) and (b): (a) a step of continuously pressurizing the liquid by a high pressure pump; and (b) a step of releasing the liquid continuously to a normal pressure within a time period of less than 10 seconds after the pressurizing step to thereby make the liquid reach the predetermined sterilizing temperature. An apparatus for automatically carrying out the method is provided. According to the continuous heat sterilization method and apparatus, scorch during the final heating step is dispensed with and accordingly, a long period of continuous operation is feasible.Type: GrantFiled: June 26, 2000Date of Patent: January 6, 2004Assignee: Morinaga Milk Industry Co., Ltd.Inventors: Kazuyoshi Sotoyama, Keiji Iwatsuki, Teruhiko Mizota, Yuzo Asano, Yasutatsu Mizota, Hiroaki Matsui, Tetsushi Mori
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Publication number: 20030228239Abstract: A method for inactivating prions comprises subjecting a substrate containing prions to one or more pulses of ultra high pressures for a predetermined period of time. The pressures is preferably at least 480 MPa for at least one second. The substrate and the prions are adiabatically heated to elevated temperatures at which the prions are inactivated.Type: ApplicationFiled: June 10, 2002Publication date: December 11, 2003Applicant: Prion Inactivation PartnersInventors: Richard S. Meyer, Paul Brown
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Patent number: 6635223Abstract: This invention is related to methods for inactivating micro-organisms using high pressure processing. A method is described for inactivating micro-organisms in a product using high pressure processing including the steps of packing said product in a flexible container, heating said product to a pre-pressurized temperature, subjecting said product to a pressure at a pressurized temperature for a time period; and reducing the pressure after said time period. The method of the present invention could further comprise an additional step of subjecting said product to a predetermined amount of oxygen for a time interval. The methods of the present invention may be applied preferably to food, cosmetic or pharmaceutical products.Type: GrantFiled: April 30, 2001Date of Patent: October 21, 2003Inventor: Andreas Maerz
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Patent number: 6613278Abstract: This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation.Type: GrantFiled: September 7, 1999Date of Patent: September 2, 2003Assignee: Regeneration Technologies, Inc.Inventors: C. Randal Mills, John F. Wironen, Sean Hanstke, Russell S. Donda, Jamie M. Grooms, John Bianchi
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Patent number: 6610251Abstract: A pressure cleaning vessel 1 is connected to a vacuum chamber P by way of a connecting pipe in the sterilizing and cleaning equipment which utilizes a supercritical fluid. The objects to be treated is impregnated, for a given period, in the supercritical fluid with which the pressure cleaning vessel 1 has been filled. Thereafter, the connection between the pressure vessel 1 and the vacuum chamber P is opened so as to generate sudden bubbling within the vessel 1 as a result of a large pressure difference. Thorough sterilization is achieved at the time when the supercritical fluid having penetrated into bacteria and viruses suddenly explodes and destroys these organisms instantly by its power of vaporization and expansion.Type: GrantFiled: November 16, 2000Date of Patent: August 26, 2003Assignee: Kabushiki Kaisha SR KaihatsuInventor: Masayuki Kanno
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Publication number: 20030103863Abstract: The invention concerns a method for sterilising at least a sensitive active principle, characterised in that said at least active principle is treated at pressure levels ranging between 3000 and 6000 bars and at temperatures ranging between −30° C. and +25° C. The method consists in treating directly the active principle in the pulverulent medium wherein it is contained.Type: ApplicationFiled: November 4, 2002Publication date: June 5, 2003Inventors: Luc Grislain, Bruno Vallayer, Gerard Demazeau, Alain Largeteau, Gilles Lemagnen, Yohan Rigaldie
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Publication number: 20020182107Abstract: The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about −40° C. to about 95° C., or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.Type: ApplicationFiled: August 7, 2001Publication date: December 5, 2002Inventors: James A. Laugharn, David W. Bradley, Robert A. Hess
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Patent number: 6471914Abstract: A process for sterilization of a liquid in a continuous system comprising a series of steps. First the liquid is continuously pumped into a pressurized system. Second, the pressure on the liquid is increased in a first pressurization stage. Next, the liquid is increased in pressure in a second pressurization stage. Fourth, the liquid is held at an elevated pressure for a predetermined period of time to kill off microorganisms within the liquid. The liquid is then rapidly depressurized to fracture microorganisms with the liquid. The apparatus for producing this process includes a continuous liquid treatment system with a pump, a first stage intensifier, a surge drum, a second stage intensifier, a pressure receiver and a pressure reducer. A particulate treatment system may also be included which comprises a pressure receiver, an intensifier, and a recoverer for blending a particulate component with the liquid component.Type: GrantFiled: December 18, 2000Date of Patent: October 29, 2002Assignee: The Coca-Cola CompanyInventors: Gerald M. Platz, N. Wayne Walkup, Howard L. Grimmett
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Patent number: 6426103Abstract: The invention relates to a process for eliminating pathogenic organisms and other bacteria from raw food products, such as raw shellfish, whereby the molluscan shellfish is exposed to hydrostatic pressure of relatively high value, for example between 20,000 p.s.i. to 150,000 p.s.i. for 1-15 minutes. The process is conducted at minimal elevated temperatures, in the range of above ambient temperature to 150° F., leaving the raw shellfish substantially unaffected, in its desired raw state, such that the pathogenic organisms are destroyed, while sensory characteristics of the raw shellfish remain high. The same process can be used for shucking bivalve mollusks without any mechanical force, with the pressure ranging from 10,000 p.s.i. to 100,000 p.s.i. Taste of raw seafood is enhanced by adding flavor enhancing agents to the pressure vessel before application of pressure.Type: GrantFiled: December 15, 2000Date of Patent: July 30, 2002Assignee: Innovatit Seafood Systems LLCInventor: Ernest A. Voisin
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Publication number: 20020076347Abstract: This invention is related to methods for inactivating micro-organisms using high pressure processing. A method is described for inactivating micro-organisms in a product using high pressure processing comprising the steps of packing said product in a flexible container, heating said product to a pre-pressurized temperature, subjecting said product to a pressure at a pressurized temperature for a time period; and reducing the pressure after said time period. The method of the present invention could further comprise an additional step of subjecting said product to a predetermined amount of oxygen for a time interval. The methods of the present invention may be applied preferably to food, cosmetic or pharmaceutical products.Type: ApplicationFiled: April 30, 2001Publication date: June 20, 2002Inventor: Andreas Maerz
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Publication number: 20020054826Abstract: In a process for sterilizing objects, the surfaces of the objects are dampened by condensating a steam compound of water and hydrogen peroxide. The steam compound reaches hereby the objects to be sterilized without any additional transport gas flow. Subsequent drying occurs by means of evacuation at a pressure below the boiling points of water and hydrogen peroxide.Type: ApplicationFiled: August 30, 2001Publication date: May 9, 2002Inventors: Robert Frost, Peter Awakowicz
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Publication number: 20010038806Abstract: A process for sterilization of a liquid in a continuous system comprising a series of steps. First the liquid is continuously pumped into a pressurized system. Second, the pressure on the liquid is increased in a first pressurization stage. Next, the liquid is increased in pressure in a second pressurization stage. Fourth, the liquid is held at an elevated pressure for a predetermined period of time to kill off microorganisms within the liquid. The liquid is then rapidly depressurized to fracture microorganisms within the liquid. The apparatus for producing this process includes a continuous liquid treatment system with a pump, a first stage intensifier, a surge drum, a second stage intensifier, a pressure receiver and a pressure reducer. A particulate treatment system may also be included which comprises a pressure receiver, an intensifier, and a recoverer for blending a particulate component with the liquid component.Type: ApplicationFiled: December 18, 2000Publication date: November 8, 2001Inventors: Gerald M. Platz, N. Wayne Walkup, Howard L. Grimmett
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Patent number: 6270723Abstract: The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about −20° C. to about 95° C.). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, the decontamination of military devices, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.Type: GrantFiled: October 2, 1998Date of Patent: August 7, 2001Assignee: BBI Bioseq, Inc.Inventors: James A. Laugharn, Jr., David W. Bradley, Robert A. Hess
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Patent number: 6162392Abstract: A process for sterilization of a liquid in a continuous system comprising a series of steps. First the liquid is continuously pumped into a pressurized system. A process for sterilization of a liquid in a continuous system where, in the first step, the liquid is continuously pumped into a pressurized system. Second, the pressure on the liquid is increased in a first pressurization stage. Next, the liquid is increased in pressure in a second pressurization stage. Fourth, the liquid is held at an elevated pressure for a predetermined period of time to kill off microorganisms within the liquid. The liquid is then rapidly depressurized to fracture microorganisms within the liquid. The apparatus for producing this process includes a continuous liquid treatment system with a pump, a first stage intensifier, a surge drum, a second stage intensifier, a pressure receiver and a pressure reducer.Type: GrantFiled: December 6, 1999Date of Patent: December 19, 2000Assignee: The Coca-Cola CompanyInventors: Gerald M. Platz, N. Wayne Walkup, Howard L. Grimmett
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Patent number: 6136609Abstract: An apparatus for processing a high-pressure liquid material has a high-pressure vessel, a pressurizing assembly for supplying a liquid material to the high-pressure vessel in order to allow the high-pressure vessel to process the liquid material under a high pressure therein, a depressurizing assembly for receiving and depressurizing the processed liquid material supplied under a high pressure from the high-pressure vessel, and a working fluid control system for controlling the depressurizing assembly. The depressurizing assembly has a plurality of cylinder device comprising respective pairs of interlinked pistons which define, in the cylinder devices, respective processing pressure chambers for selectively receiving the liquid material from the high-pressure vessel, and respective working pressure chambers for selectively receiving a working fluid from the working fluid control system.Type: GrantFiled: August 21, 1995Date of Patent: October 24, 2000Assignee: Kagome Kabushiki KaishaInventors: Tetsu Sato, Takahiro Inakuma, Yukio Ishiguro, Naoji Komeya, Masami Shibamoto, Yukio Matsuda
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Patent number: 6120732Abstract: Processes and apparati for inactivating microorganisms in flowing or pulsed liquids are provided. The processes consist of pressurizing the liquid and then depressurizing the liquid by directing it through one or more constrictions into an area of reduced pressure. The apparati comprise two fluid containing vessels, one of which is capable of being pressurized, the two vessels being in fluid communication through one or more constrictions, one or more of which may be adjustable, and a means for increasing pressure in one vessel. Specific embodiments include the use of a pressure intensifer to pressurize the liquid and an adjustable orifice, such as a micrometering valve, to form the constriction(s).Type: GrantFiled: June 23, 1998Date of Patent: September 19, 2000Assignee: University of Georgia Research Foundation, Inc.Inventors: Romeo T. Toledo, Joe Edgar Moorman, Jr.
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Patent number: 6086723Abstract: A process for deodorizing and subsequently cooling dispersions or liquids comprisinga) passing steam through the dispersion or liquid to be cooled and held in a vessel (1), said dispersion or liquid being caused to foam up as a result,b) discharging the foam from the top section of the vessel via a nozzle (5) into an evacuated separation vessel (4), the foam being broken in the process,c) condensing the water vapor formed from the foam in a heat exchanger (8) and removing volatile organic components at the same time, andd) returning the broken foam to the vessel (1),in which the steps a) to d) are performed until the dispersion or liquid has been deodorized to the desired extent, wherein, after completion of the deodorization (in accordance with steps a) to d)), the hot dispersion or liquid is discharged from the bottom section of the vessel (1) through the nozzle (5) into the evacuated separation vessel (4), so that the dispersion or the liquid is cooled, the nozzle (5) and the evacuated separation vessel (4Type: GrantFiled: August 17, 1998Date of Patent: July 11, 2000Assignee: BASF AktiengesellschaftInventors: Wolfgang Hubinger, Rainer Wunder, Gerhard Bauer, Johannes Dobbelaar, Sven Lawrenz, Franz-Josef Mueseler, Jurgen Nahstoll, Robert Rupaner, Christian-Ulrich Schmidt
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Patent number: 6004508Abstract: A process for sterilization of a liquid in a continuous system including a series of steps. First the liquid is continuously pumped into a pressurized system. Second, the pressure on the liquid is increased in a first pressurization stage. Next, the liquid is increased in pressure in a second pressurization stage. Fourth, the liquid is held at an elevated pressure for a predetermined period of time to kill off microorganisms within the liquid. The liquid is then rapidly depressurized to fracture microorganisms within the liquid. The apparatus for producing this process includes a continuous liquid treatment system with a pump, a first stage intensifier, a surge drum, a second stage intensifier, a pressure receiver and a pressure reducer. A particulate treatment system may also be included which includes a pressure receiver, an intensifier, and a recoverer for blending a particulate component with the liquid component.Type: GrantFiled: August 1, 1997Date of Patent: December 21, 1999Assignee: The Coca-Cola CompanyInventors: Gerald M. Platz, N. Wayne Walkup, Howard L. Grimmett
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Patent number: 5996478Abstract: An improved method and apparatus for pressure processing a pumpable substance are shown and described. In a preferred embodiment, a valve is coupled to a source of a pumpable food substance and a pressure vessel, the valve being movable to a first, second and third position. When the valve is in a first position, an inlet port in the valve is aligned with a passageway that is open to the pressure vessel. When the valve is in the second position, the valve body seals the passageway, and when the valve is in the third position, an outlet port provided in the valve is aligned with the passageway.Type: GrantFiled: January 23, 1996Date of Patent: December 7, 1999Assignee: Flow International CorporationInventors: Bruce M. Schuman, Edmund Y. Ting
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Patent number: 5948356Abstract: A semi-continuous process for high-pressure sterilization of a liquid or solid product, in which the sterilization of successive volumes of the product is performed by compressing the product at high pressure in a variable treatment chamber of generally tubular shape and of circular cross-section.Type: GrantFiled: December 19, 1997Date of Patent: September 7, 1999Assignee: FramatomeInventors: Bernard Lhenry, Plantadis Remy