Spreading Patents (Class 422/423)
  • Patent number: 10866237
    Abstract: Disclosed is an ultrahigh-sensitivity two-dimensional chromatography-based biosensor, wherein cross-flow of high driving force across a narrow membrane is applied, thereby enabling the elimination of background noise, efficient supply of a large-sized polymeric or high-molecular-weight signal tracer, sequential material supply for increased reactivity, and simultaneous washing and signal generation when additional signal generation is required, as in an enzyme.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: December 15, 2020
    Assignee: Korea University Research and Business Foundation
    Inventor: Se-Hwan Paek
  • Patent number: 10613097
    Abstract: A method of quantitatively determining the concentration of at least one analyte in a sample by: (i) adding a portion of the sample to a first analyte assay formulation and to an analyte assay reference formulation to generate a first analyte sample and analyte reference sample and determining the concentration of the at least one analyte in the sample and/or (ii) adding a portion of the sample to a second analyte assay formulation and determining the concentration of the at least one analyte in the sample, as well as formulations, kits of parts, systems and computer implemented methods associated with the method.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 7, 2020
    Assignee: Nitto Denko Corporation
    Inventors: Xiaojun Chen, Yingsong Wang, Pei Shan Ho, Xi Er Yeo
  • Patent number: 10591477
    Abstract: Lateral flow devices, methods and kits for performing lateral flow western blot assays are provided.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: March 17, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: William Strong
  • Patent number: 10578615
    Abstract: Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of whole cells.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: March 3, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Rick Haselton, David Wright, Nick Adams, Keersten Ricks
  • Patent number: 10436782
    Abstract: A device for immunochromatographic assay includes a housing and a vessel body. The housing has an upwardly-extending hollow protrusion for housing the vessel body. The vessel body has a vessel body wall and a vessel body bottom. A raised tip and a fence surrounding the tip are arranged in the housing. The vessel body and the raised tip can be moved towards each other such that the raised tip can break the vessel body bottom to release liquid in the vessel body.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: October 8, 2019
    Inventor: Hai Zhu
  • Patent number: 10345294
    Abstract: The present invention intends to provide an immunochromatographic test piece that makes it possible to achieve both highly sensitive detection of a substance to be detected and a simple test piece structure, which are usually difficult to be made compatible with each other.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: July 9, 2019
    Assignee: Denka Seiken Co., Ltd.
    Inventors: Risa Kohiyama, Osamu Ishikawa, Takashi Miyazawa
  • Patent number: 10159711
    Abstract: The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: December 25, 2018
    Assignee: Salk Institute for Biological Studies
    Inventors: Johan W. Jonker, Michael Downes, Ronald M. Evans, Jae Myoung Suh
  • Patent number: 10151736
    Abstract: The present invention relates to a process for the detection and adsorption of arsenic from ground water and industrial waste water using lanthanide doped nanoparticles. More particularly, the present invention provides a process for the detection and adsorption arsenic in ppm level using Eu0.05Y0.95PO4 nanoparticles.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: December 11, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Meitram Niraj Luwang, Debasish Ghosh
  • Patent number: 10106832
    Abstract: The present invention provides a method for manufacturing a microbial detection device, microbial detection method, microbial detection kit and microbial detection device. The manufacturing method includes the following steps: defining a sampling portion and a reaction portion on a substrate. Fiber materials are disposed in the reaction portion and a surface of the reaction portion which contacts with the fiber materials comprises abundant hydroxyl groups. Reaction reagents are then added into the fiber materials. An acidic solution is applied to treat the fiber materials and the hydroxyl groups in the reaction portion.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 23, 2018
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Chen-Meng Kuan, Robert S. Langer, Chao-Min Cheng
  • Patent number: 10079073
    Abstract: The technology described in this document can be embodied in a test strip for use in measuring a level of an ST2 cardiac biomarker in a blood plasma sample. The test strip includes a base, and a plurality of conjugates, wherein each conjugate includes a reporter group bound to a first antibody that binds to ST2. A conjugate pad disposed along a length of the base and is configured to hold the plurality of conjugates that bind with ST2 to produce conjugate-ST2 complexes. The conjugate pad is further configured to receive the blood plasma sample. The test strip also includes a plurality of second and third antibodies that bind to ST2, and the conjugate-ST2 complexes, respectively. The plurality of second antibodies are bound to a membrane in a test location and the plurality of third antibodies are bound to the membrane in a control location.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: September 18, 2018
    Assignee: Critical Care Diagnostics, Inc.
    Inventors: James V. Snider, Jillian Elizabeth Bender, Shrin P. Kuo, Roy A. Chung
  • Patent number: 9950280
    Abstract: The invention provides methods and devices for isolating chromatin from liquid samples. The devices have a rigid porous matrix on which a ligand is immobilized, with the ligand binding to a protein associated with the chromatin.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 24, 2018
    Assignee: Porvair Filtration Group Limited
    Inventors: Igor Chernukhin, Elena Klenova, David Cowieson, Samantha Brown
  • Patent number: 9921220
    Abstract: Disclosed is a cell wall C-polysaccharide antigen of Streptococcus pneumoniae which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1N Na OH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against Streptococcus pneumoniae which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 20, 2018
    Assignee: Alere Scarborough, Inc.
    Inventors: Norman J. Moore, Mary K. Konstantin, Vladimir A. Koulchin, Elena V. Molokova
  • Patent number: 9797898
    Abstract: Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: October 24, 2017
    Assignee: RAPID PATHOGEN SCREENING, INC.
    Inventors: Uma Mahesh Babu, Robert P. Sambursky
  • Patent number: 9784734
    Abstract: Systems include test cells with sorbent material in a T-shape and defining a first flow path for a solution and a second flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules located at the junction of the T. A housing houses the sorbent material and defines a first hole adjacent an end of the first flow path for receiving the solution and a second hole adjacent an end of the second flow path for receiving the sample.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: October 10, 2017
    Assignee: CHEMBIO DIAGNOSTIC SYSTEMS, INC.
    Inventor: Javanbakhsh Esfandiari
  • Patent number: 9745541
    Abstract: Provided are methods, processes and systems for treating a soapstock. In alternative embodiments, provided are systems and methods for treating a soapstock to generate free fatty acids and/or fatty acid derivatives, e.g. fatty acid alkyl esters. In alternative embodiments, provided are systems and methods for realizing the full fatty acid yield of a soapstock by first converting substantially all of the saponifiable material in a soapstock to salts of fatty acids (soaps) and acidulating the soaps to generate free fatty acids and/or fatty acid derivatives, e.g. fatty acid alkyl esters, wherein the soapstock comprises soaps and saponifiable lipids, e.g. glycerides and/or phospholipids, and the generating of free fatty acids and/or fatty acid is achieved.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 29, 2017
    Assignee: INVENTURE RENEWABLES, INC.
    Inventors: William Rusty Sutterlin, Ryan Alexander Long, Cory Oneil Blanchard, John Brown
  • Patent number: 9702872
    Abstract: A rapid diagnostic test device uses driven flow technology to significantly expedite the testing time of a sample. The rapid diagnostic test device can be used to analyze liquids, such as some body fluids, by using labeled molecular affinity binding, such as immunochromatography. The test device can detect an analyte, such as an antibody or antigen, which may indicate a particular condition, the presence of a particular drug, or the like. The device includes a cover and base that combine to form an internal cavity for receiving a test strip. Compression bars in the cover and a compression cushion in the base sandwich a conjugate pad of the test strip to accelerate chemical mixtures to flow from the conjugate pad of the test strip toward fixed sites along the strip from which readings are taken.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: July 11, 2017
    Assignee: DNT SCIENTIFIC RESEARCH, LLC
    Inventors: Naishu Wang, Michael Chang Chien
  • Patent number: 9670524
    Abstract: Test elements are disclosed for detecting at least one analyte concentration in a sample. The test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of at least one diffusable label.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: June 6, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Carina Horn, Volker Unkrig
  • Patent number: 9645173
    Abstract: A test carrier includes a base member and a cover member. The base member includes a multi-layer board including a wiring line that is electrically connected to a die and a base film that supports the multi-layer board. The cover member includes a frame-shaped cover frame having an opening formed therein. The size of the multi-layer board is larger than the size of the die and is smaller than the size of the opening in a direction along a surface that is opposite to the die.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: May 9, 2017
    Assignee: ADVANTEST CORPORATION
    Inventor: Kiyoto Nakamura
  • Patent number: 9632083
    Abstract: A rapid diagnostic test device uses driven flow technology to significantly expedite the testing time of a sample. The rapid diagnostic test device can be used to analyze liquids, such as some body fluids, by using labeled molecular affinity binding, such as immunochromatography. The test device can detect an analyte, such as an antibody or antigen, which may indicate a particular condition, the presence of a particular drug, or the like. The device includes a top and bottom that combine to form a fluid channel through which a fluid is forced from a fluid collector. A press pad in the device may press against a press pad on a test strip to accelerate chemical mixtures to flow from the conjugate color pad of the test strip toward fixed sites along the strip from which readings are taken.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: April 25, 2017
    Assignee: DNT Scientific Research, LLC
    Inventors: Naishu Wang, Michael Chang Chien
  • Patent number: 9581551
    Abstract: The following description relates to a composite for a harmful material-detecting sensor, which includes a dye having a color-change function by reaction with acid or base and a polymer material, a method for producing the composite for the harmful material-detecting sensor, and a low-cost film-type color change harmful material sensor, which includes the composite for the harmful material-detecting sensor so as to quickly detect a harmful material and can be carried by an individual.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: February 28, 2017
    Assignee: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
    Inventors: Jeong Ho An, Dong Jun Chung
  • Patent number: 9538944
    Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: January 10, 2017
    Assignee: University of Maryland Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Xudong Ge, Leah Tolosa, Hyung Woo, Rose Viscardi
  • Patent number: 9442106
    Abstract: The system includes a simple system for CD4 and CD8 counting in point-of-care HIV staging within resource poor countries. Unlike previous approaches, no sample preparation is required with the sample added directly to a chip containing dried reagents by capillary flow. A large area image cytometer consisting of an LED module is used to excite the fluorochromes PerCP and APC labeled targets and a monochrome CCD camera with a combination of two macro lenses captures images of 40 mm2 of blood (approximately 1 micro liter). CD4 and CD8-T-lymphocyte counts correlate well with those obtained by flow cytometry. The cytometer system described in the present invention provides an affordable and easy-to-use technique for use in remote locations.
    Type: Grant
    Filed: May 8, 2011
    Date of Patent: September 13, 2016
    Assignee: Universiteit Twente
    Inventors: Markus Beck, Leon L. W. M. M. Terstappen
  • Patent number: 9377457
    Abstract: A cartridge and method for conducting a labeled molecular affinity binding test such as antibody/antigen, ligand/receptor, and colorometric reactions, and other chemical reactions for which one or more analytes is present in a liquid sample formate. A progressive compression structure progressively forces a liquid flow out of a conjugate pad toward a reaction region to more thoroughly and rapidly mix the liquid, encouraging specific first affinity binding to the analytes in question. A specially dimensioned constricting passageway surrounding the reaction region including the result zones provides an additional siphoning force to the flow. These combined forces rapidly and more evenly guide the flow of liquid through the reaction region so that the rushed rate of uptake of analytes at the strip lines are more evenly distributed, adhesive attachment of non-specific molecules is largely avoided, vastly improving sensitivity and specificity, and providing quantitative results in some tests.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: June 28, 2016
    Inventors: Naishu Wang, David F. Zhou
  • Patent number: 9205375
    Abstract: Apparatuses and methods for removing carbon dioxide and other pollutants including heavy metals from a gas stream are provided. The methods include obtaining a water-condensate from the flue-gas stream; obtaining a chloride salt; admixing the salt with water, steam, or both to produce a solution; electrolyzing the solution to produce a hydroxide and chlorine gas; admixing a portion of the hydroxide with the flue-gas stream to produce carbonate products, bicarbonate products, or a mixture of carbonate and bicarbonate products in an admixture; separating said carbonate and/or bicarbonate products from the admixture, thereby removing carbon dioxide from the flue-gas stream; adding a portion of the hydroxide to the water-condensate to change the pH of the water-condensate from acidic to basic, resulting in precipitation of the heavy metals; and passing the water-condensate through a filtering medium.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: December 8, 2015
    Assignee: SKYONIC CORPORATION
    Inventors: Joe David Jones, David St. Angelo
  • Patent number: 9074945
    Abstract: A temperature measuring insert composed of ceramic or sintered materials of magnesium oxide or aluminum oxide accomodates, on its end facing the measured medium, temperature sensor elements, such as thermocouples and temperature measuring resistors, as a measuring tip, installable singly or with others in metal or ceramic protective tubes. The site of the measuring tip, a water adsorption behavior differing from the remaining measuring insert material is present, in order to protect the temperature sensor elements in the case of rapid process related temperature changes, in order to prevent, in the case of heating, effects due to superheated steam.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: July 7, 2015
    Assignee: ENDRESS + HAUSER WETZER GMBH + CO. KG
    Inventors: Wilfried Meissner, Helmut Kalteis, Peter Seefeld
  • Patent number: 9028771
    Abstract: The invention provides a modified form of saturation assay, which is based on the measurement of a free or unbound labelled reagent fraction (such that there is an increase in signal in the presence of analyte) and employs trapping zones to concentrate said unbound or free labelled fraction to avoid loss of sensitivity. Preferably, the assay is a membrane assay.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: May 12, 2015
    Assignee: Platform Diagnostics Limited
    Inventors: Douglas Robert Evans, Gerald John Allen, Carolyn Jennifer Ruddell
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Publication number: 20150086974
    Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.
    Type: Application
    Filed: April 1, 2013
    Publication date: March 26, 2015
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
  • Patent number: 8986625
    Abstract: A method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of the hydrogen sulphide by forming a sulphur-containing solid product which is different in color from the solid reagent, and recovering the sulphur-containing solid product. The invention also relates to a device suitable for the implementation of this method.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: March 24, 2015
    Assignee: Total S.A.
    Inventors: Daniel Dessort, Robert Le Van Loï, Nadine Loubere
  • Patent number: 8980572
    Abstract: A method for generating and localizing a signal in a solid phase substrate detection system comprises applying a solution of target material to a substrate; binding the target with a specific affinity molecule having an attached label, the label comprising multiple signal precursor molecules; applying a carrier to the substrate, and treating the label to convert the signal precursor molecules to signal generating molecules. The carrier comprises solvent for the label and thickener for localizing the signal. The carrier may include developer that converts signal precursor molecules to signal generating molecules. Developer is not necessary if the signal precursor molecules are converted to signal generating molecules by e.g. temperature change, pH change, sonication, light irradiation, microwave heating. A test device for detecting target in a fluid sample, and a kit of parts for determining the presence of target in a fluid sample are also disclosed.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: March 17, 2015
    Assignee: Supernova Diagnostics, Inc.
    Inventors: Ling Wai Wong, Pui Yee Cangel Chan, Wing Cheung Mak, King Keung Sin, Reinhard Renneberg
  • Publication number: 20150064692
    Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.
    Type: Application
    Filed: April 1, 2013
    Publication date: March 5, 2015
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
  • Patent number: 8968677
    Abstract: An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: March 3, 2015
    Assignee: Quantum Design International, Inc.
    Inventors: Ronald T. LaBorde, Nicholas J. Neild
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Patent number: 8940234
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: January 27, 2015
    Assignee: Intel Corporation
    Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Patent number: 8940237
    Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: January 27, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
  • Patent number: 8936804
    Abstract: This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: January 20, 2015
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Sheldon Suton Lin, David Naisby Paglia, James Patrick O'Connor, Eric Breitbart, Joseph Benevenia
  • Patent number: 8932537
    Abstract: A portable tester to detect one or more analytes from explosives, drugs, or household chemicals, comprising: a plurality of chemical disposable, detachable reagent reservoirs storing reagents to induce a series of color reactions, wherein developed color depends on sequences of applied reagents to respective pads on a support base, reaction times and temperatures on said pad to create one or more color bar codes for a specific analyte. The tester comprises a piezoelectric dispenser coupled to each respective reservoir to dispense a mist of reagent onto respective test pads to increase sensitivity and reduce reaction heat and time; wherein piezoelectric dispenser is processor controlled to control dispensing time and volume in each step.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: January 13, 2015
    Assignee: Chemspectra, Inc.
    Inventors: Jeffrey Haas, Douglas Haas
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8916110
    Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 23, 2014
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Patent number: 8911681
    Abstract: A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous-based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 16, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Karen Meloy Goeders, Ning Wei
  • Publication number: 20140356253
    Abstract: The present invention provides a biomedical device comprising a porous hydrophilic substrate; a hydrophobic material; a fluid inlet; two or more test zones, wherein fluid vertically flows through the porous hydrophilic substrate and then distributes into the test zones. The present invention further provides a method for making a biomedical device.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 4, 2014
    Applicant: ETERNAL CHEMICAL CO., LTD.
    Inventors: Tu-Yi Wu, Chao-Min Cheng, Hsi-Kai Wang, Yen-Ting Yeh, Wei-Ming Tu
  • Patent number: 8865089
    Abstract: Described here are systems, devices, cartridges, methods, and kits for detecting or quantifying at least two different analytes using at least two different techniques, in a single sample. The cartridges typically comprise at least two test sites and the location of at least one test site is not dependent on a corresponding measurement device. The systems generally comprise a device, memory, and a processing module. The device comprises a light source, an array detector, and a port configured to accept at least a portion of a cartridge. The processing module is configured to perform an image analysis of the cartridge. The methods comprise the steps of acquiring calibration information, acquiring an image of the cartridge, performing an image analysis, and cycling through specific detection or quantification techniques corresponding to the techniques required by the test sites. Computer readable media are also described.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: October 21, 2014
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Joel M. Blatt, Carole R. Stivers
  • Patent number: 8858884
    Abstract: A sterilization indicator system and method of using the system to determine efficacy of a sterilization process. The system includes a vial having a first compartment containing spores of one or more species of microorganism; a second compartment containing a growth medium with a disaccharide, an oligosaccharide or a polysaccharide in which the vial is free of monosaccharide; an enzyme, capable of acting upon the monosaccharide to yield reaction products and electron transfer, disposed on two or more electrodes adapted to carry an electrical signal resulting from the electron transfer, the pair of electrodes positioned to contact the combined contents of the first compartment and the second compartment during incubation; and an apparatus linked or linkable to the electrodes and adapted to detect and measure the electrical signal resulting from electron transfer when the enzyme acts upon the monosaccharide.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 14, 2014
    Assignee: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Patent number: 8852515
    Abstract: The problem is to provide a multilayer analysis element for analyzing liquid samples, having improved adhesive force between a transparent support and a detection layer even by handling at the time of processing, while maintaining basic performances such as sensitivity and storage performance. The multilayer analysis element for analyzing liquid samples is characterized in that at least a detection layer containing a substance that generates a detectable change by a gaseous substance, a liquid blocking layer that selectively permeates the gaseous substance, and a spreading layer are integrally adhesion laminated in this order on a transparent support, and the detection layer contains an adhesive polymer and a water-insoluble vinyl polymer.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: October 7, 2014
    Assignee: FUJIFILM Corporation
    Inventor: Hideaki Tanaka
  • Patent number: 8747773
    Abstract: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 10, 2014
    Inventor: Maryse Thomas
  • Patent number: 8748193
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: June 10, 2014
    Assignee: Baylor College of Medicine
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Patent number: 8722417
    Abstract: An apparatus is provided for sensing an analyte in a fluid.
    Type: Grant
    Filed: January 20, 2007
    Date of Patent: May 13, 2014
    Assignee: Invoy Technologies, L.L.C.
    Inventor: Lubna Ahmad
  • Patent number: 8721990
    Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: May 13, 2014
    Assignee: Alere Switzerland GmbH
    Inventors: Balbir Raj, Saji Eapen, Ezra Linley
  • Patent number: 8716028
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: May 6, 2014
    Assignee: Nalco Company
    Inventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8697006
    Abstract: A reagent or particles having reagent supported thereon are applied to a matrix material by a contact printing process for example in which the matrix material is brought into contact with a rotating contact roll having the reagent or particles having reagent supported thereon disposed thereon so as to transfer the reagent or particles having reagent supported thereon to the matrix material. Such a contact printing processes allow high speed and high volume production of an assay device.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: April 15, 2014
    Assignee: Orion Diagnostica Oy
    Inventors: Veli-Mies Häivä, Anna Kaisa Kylmä, Juhani Luotola