Analyzer, Structured Indicator, Or Manipulative Laboratory Device Patents (Class 422/50)
  • Patent number: 10292586
    Abstract: The present invention relates to a non-invasive health indicator monitoring system including a sensing module, an electric power storage module, and a circuit module to collect health indicator information by contacting with a subject. In addition, the present invention also relates to a method for monitoring health indicator continuously by using the health indicator monitoring system.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: May 21, 2019
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yong Won Song, Su Youn Lee, Ji Yeon Lee, Jung Ah Lim, Ji Won Choi, Byung Ki Cheong, Jin Seok Kim, Ho Seong Jang, Hyun Jung Yi
  • Patent number: 10279350
    Abstract: Methods of generating droplets. In an exemplary method, a device including a sample well, a carrier well, a droplet well, and a plurality of microfluidic channels is selected. The microfluidic channels include a first channel, a second channel, and a third channel. A discrete volume of sample-containing fluid is placed into the sample well, and a discrete volume of carrier fluid is placed into the carrier well. A pressure differential is created after placing the discrete volumes, to cause fluid flow. Sample-containing fluid flows from the sample well to a droplet-generation region of the device via the first channel. Carrier fluid flows from the carrier well to the droplet-generation region via the second channel. Sample-containing droplets and carrier fluid flow from the droplet-generation region to the droplet well via the third channel.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: May 7, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Benjamin J. Hindson, Kevin D. Ness, Billy W. Colston, Jr., Fred P. Milanovich, Donald A. Masquelier
  • Patent number: 10279343
    Abstract: A transfer device for the contamination free transfer of biological material from a sealed chamber to a recipient. The transfer device includes a support having a first docking area and a second docking area. The first docking area has at least one inlet port, each inlet port creating a fluid connection with one sealed chamber. The second docking area has at least one outlet port, each outlet port creating a fluid connection with a recipient. The first docking area further includes a piercing element designed for piercing a sealing element of a sealed chamber in order to allow, together with at least one inlet port, a fluid connection between a pierced sealed chamber and the inlet port, to allow a contamination free transfer of the biological material from the pierced sealed chamber to at least one recipient.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: May 7, 2019
    Assignee: Biocartis NV
    Inventors: Nicolas Vergauwe, Thierry Tollenboom
  • Patent number: 10261012
    Abstract: This disclosure concerns methods and apparatus for interferometric spectroscopic measurements of particles with higher signal to noise ratio utilizing an infrared light beam that is split into two beams. At least one beam may be directed through a measurement volume containing a sample including a medium. The two beams may then be recombined and measured by a detector. The phase differential between the two beams may be selected to provide destructive interference when no particle is present in the measurement volume. A sample including medium with a particle is introduced to the measurement volume and the detected change resulting from at least one of resonant mid-infrared absorption, non-resonant mid-infrared absorption, and scattering by the particle may be used to determine a property of the particle. A wide range of properties of particles may be determined, wherein the particles may include living cells.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: April 16, 2019
    Assignee: 1087 Systems, Inc.
    Inventor: Matthias Wagner
  • Patent number: 10260168
    Abstract: Contemplated microfluidic devices and methods are drawn to protein arrays in which distinct and detergent-containing antigen preparations are deposited onto an optical contrast layer in a non-specific and non-covalent manner. Detection of binding a is carried out using a dye that precipitates or agglomerates to so form a visually detectable signal at a dynamic range of at least three orders of magnitude.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: April 16, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Abraham Lee, Philip Felgner, Armando Tovar, Uland Liao
  • Patent number: 10252266
    Abstract: In some aspects, the present disclose provides methods for amplifying and quantifying nucleic acids. Methods for amplifying and quantifying nucleic acids comprise isolating a sample comprising nucleic acid molecules into a plurality of microchambers, performing a polymerase chain reaction on the plurality of microchambers, and analyzing the results of the polymerase chain reaction. In some aspects, the present disclosure provides devices consistent with the methods herein.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: April 9, 2019
    Assignee: COMBINATI INCORPORATED
    Inventors: Ju-Sung Hung, Andrew Zayac, Megan Dueck
  • Patent number: 10227634
    Abstract: The present disclosure relates generally to the integration of isotachophoresis (ITP) and isothermal nucleic acid amplification methods such as recombinase polymerase amplification (RPA). One aspect of the disclosure relates to a method for concentrating and amplifying a nucleic acid, the method including an isotachophoresis device, the isotachophoresis device including a porous matrix, and first and second electrodes, having a leading electrolyte, a trailing electrolyte and a set of isothermal nucleic acid amplification reaction reagents disposed in the porous matrix as described herein, and applying a voltage across the first electrode and the second electrode for a time sufficient to provide a first isotachophoresis (ITP) plug comprising an amplification product of the nucleic acid, wherein the concentration of the nucleic acid is substantially higher in the first FTP plug than in the first and/or second fluids outside of the first ITP plug.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 12, 2019
    Assignee: University of Washington
    Inventors: Jonathan D. Posner, Mark D. Borysiak, Kevin Kimura
  • Patent number: 10229564
    Abstract: An apparatus provides tactile stimulus to a human user using a tri-layer actuator comprising: first and second polymer layers which are electronically and ionically conductive and have one or more dimensions which vary in dependence on insertion of ions therein and withdrawal of ions therefrom; and a deformable layer located between the first and second polymer layers to physically separate the first and second polymer layers from one another, the deformable layer electronically insulating and ionically conductive. Application of first and second voltages between the first and second polymer layers creates corresponding first and second distributions of ions within the first and second polymer layers. Changing between application of the first and second voltages causes corresponding deformation of the tri-layer actuator between corresponding first and second shapes, a difference or transition between the first and second shapes detectable by a sense of touch of a human user.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 12, 2019
    Assignee: The University of British Columbia
    Inventors: Saeedeh Ebrahimi Takalloo, John D. W. Madden, Shahriar Mirabbasi, Meisam Farajollahi
  • Patent number: 10222254
    Abstract: A sample analyzing apparatus for performing an optical-based measurement on a sample includes a housing, a first light source, excitation optics, a first light detector, emission optics, and a monitoring system, all of which are disposed in the housing. The monitoring system is configured for monitoring a movable component disposed in the housing. The monitoring system includes one or more light sources for illuminating the movable component, and one or more light detectors for detecting light reflected from the movable component in response to being illuminated.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: March 5, 2019
    Assignee: Molecular Devices (Austria) GmbH
    Inventors: Michael Katzlinger, Georg Kronberger, Bernhard Schinwald
  • Patent number: 10208334
    Abstract: Systems, methods and compositions of matter according to the present invention, can be used in capture/enrichment, gene expression profiling and targeted sequencing. Provided are systems, methods and compositions concerning the enhancement of nucleic acid hybridization specificity and controlling the shapes of melting curves revealed by nucleic acid hybrid pairs to optimize nucleic acid analysis. These systems, methods and compositions comprise producing a positively charged surface or surface coating, on the surface of microarray slides or other types of surfaces similarly purposed, which enhances melting curve analysis to the point of allowing detection or differentiation of small changes in sequences between nucleic acid binding partners. The accuracy or resolution of melting curve analysis was to be sufficient to distinguish between the melting of perfect matched dsDNA and dsDNA with the smallest possible change in sequence, a one base pair mismatch.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 19, 2019
    Inventor: Michael D. Okura
  • Patent number: 10188340
    Abstract: A handheld, conforming capacitive sensing apparatus configured to measure Sub-Epidermal Moisture (SEM) as a mean to detect and monitor the formation of pressure ulcers. The device incorporates an array of electrodes which are excited to measure and scan SEM in a programmable and multiplexed manner by a battery-less RF-powered chip. The scanning operation is initiated by an interrogator which excites a coil embedded in the apparatus and provides the needed energy burst to support the scanning/reading operation. Each electrode measures the equivalent sub-epidermal capacitance corresponding and representing the moisture content.
    Type: Grant
    Filed: April 9, 2016
    Date of Patent: January 29, 2019
    Assignees: Bruin Biometrics, LLC, The Regents of the University of California
    Inventors: Majid Sarrafzadeh, William Kaiser, Alireza Mehrnia, Barbara M. Bates-Jensen, Frank Wang, Michael Flesch, Joseph Boystak, Yeung Lam
  • Patent number: 10184934
    Abstract: Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: January 22, 2019
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Jack Coleman, Maciej Szczepanik, Richard Jin
  • Patent number: 10180567
    Abstract: An optical modulator element includes a plurality of hole structure, a first liquid reservoir that stores a liquid to be propelled into the plurality of hole structure, a plurality of second liquid reservoirs that store the liquid to be propelled into the plurality of hole structure, and a movement control part that is arranged at at least one end of the second liquid reservoir that is closest to the first liquid reservoir and controls a movement of the liquid from the first liquid reservoir.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: January 15, 2019
    Assignee: RICOH COMPANY, LTD.
    Inventor: Suguru Sangu
  • Patent number: 10174305
    Abstract: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: January 8, 2019
    Assignee: The General Hospital Corporation
    Inventors: Jon F. Edd, Mehmet Toner, Dino DiCarlo, Daniel Irimia
  • Patent number: 10156555
    Abstract: The invention relates to a device and a method for determining at least one physical, chemical and/or biological characteristic of a liquid medium that has been introduced into a sealable container, said device comprising at least: one measuring head system comprising at least one pressure measuring unit for measuring the pressure of a gaseous medium and/or of the liquid medium present in the container and a temperature measuring unit for measuring the temperature of the gaseous medium and/or of the liquid medium; one movement system, at least for moving the container; and one determination system, at least for determining the physical, chemical and/or biological characteristic of the liquid medium from at least one of the individual values relating to the measured pressure and the measured temperature of the medium.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: December 18, 2018
    Assignee: Steinfurth Mess-Systeme GmbH
    Inventor: Martin Falkenstein
  • Patent number: 10147976
    Abstract: A battery assembly heat insulating container includes a box body and a lid body. The box body has an opening on its upper surface, and contains a battery module formed by connecting a plurality of battery cells in series or in parallel. The lid body is placed on the upper surface of the box body. The battery assembly heat insulating container is adapted to provide heat insulation between an external space and an internal space formed by the box body and the lid body and configured to contain the battery module. A circuit member configured to detect leakage of active material from the battery module is provided at the bottom of the box body.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: December 4, 2018
    Assignee: NGK Insulators, Ltd.
    Inventor: Motohiro Fukuhara
  • Patent number: 10139407
    Abstract: A method for characterizing bacteria includes passing a liquid containing an analyte comprising a first bacteria and a second bacteria over and in contact with a polymer material on a substrate. The polymer material is formulated to bind to the first bacteria, and the first bacteria binds to the polymer material with a higher affinity than the second bacteria. A heat transfer property of the polymer material varies based on an amount of the analyte bound thereto. The method further includes binding a portion of the first bacteria and the second bacteria of the analyte to the polymer material, removing at least a portion of the second bacteria from the polymer material, detecting a temperature of the substrate, and calculating a concentration of the first bacteria in the liquid based at least in part on the temperature of the substrate.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: November 27, 2018
    Assignees: Universiteit Maastricht, Academisch Ziekenhuis Maastricht
    Inventors: Bart Robert Nicolaas Van Grinsven, Thomas Jan Cleij
  • Patent number: 10131934
    Abstract: A method for carrying out nucleic acid amplification reactions using a microfluidic device is described. Amplification primers and other amplification reagents are deposited at a plurality of reaction sites in the device, a sample solution containing amplifiable polynucleotides is introduced into the reaction sites, and amplification is carried out.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: November 20, 2018
    Assignee: Fluidigm Corporation
    Inventors: Marc Unger, Ian D. Manger, Michael Lucero, Yong Yi, Emily Miyashita-Lin, Anja Wienecke, Geoffrey Facer
  • Patent number: 10132791
    Abstract: A device and system for automatic handling of a sensor strip by a part of a meter that includes a sensor strip having a first section, a second section, and an intermediate section. The sensor strip includes at least a first opening about a first end thereof and a second opening about a second end thereof. A meter part includes a pair of pivoting catches configured to engage and grasp a sensor strip from a container containing a plurality of sensor strips. The sensor strip may thus be removed from a container for testing without need for manual handling of the strip by a user.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: November 20, 2018
    Assignee: Ascensia Diagnostics Care Holdings AG
    Inventor: Steven C. Charlton
  • Patent number: 10126296
    Abstract: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: November 13, 2018
    Assignee: Abbott Point of Care Inc.
    Inventor: Cary James Miller
  • Patent number: 10119643
    Abstract: A fuel piping structure includes a fuel pipe, a pressure sensor in communication with the fuel pipe through a communication channel, and a sensor holding part including a projecting part projecting to an outer-peripheral side, being connected to the fuel pipe, and holding the pressure sensor disposed therein. A ring-shaped elastic member is provided between an underside of the projecting part and the fuel pipe, the projecting part being pressed against the fuel pipe. The tip side of the sensor holding part on which a ring-shaped seal member is provided is inserted into a recessed part of the fuel pipe and in communication with the inside of the fuel pipe, and the communication channel is in communication with the recessed part. In the sensor holding part, a conduction channel for a seal test is formed from an end face of the projecting part to the seal member.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: November 6, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Tasuku Yanagimoto, Masaharu Ichise
  • Patent number: 10078054
    Abstract: A system and method is provided for detection at least one of nitrite (NO2), nitric oxide (NO), nitrogen dioxide (NO2), and other nitrogen oxides (NOx) on a substrate, such as skin. According to one aspect, a diagnostic device for measuring a concentration of at least one of nitrite (NO2), nitrogen dioxide (NO2), nitric oxide (NO), and other nitrogen oxides (NOx) on a substrate comprises a patch comprising at least one chemical compound capable of reacting with the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides to provide an indicator.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: September 18, 2018
    Assignee: AOBIOME LLC
    Inventors: James Heywood, David R. Whitlock
  • Patent number: 10078078
    Abstract: The invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. Also provided are methods for washing magnetically responsive beads using shape-assisted merging of droplets. Also provided are methods for shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magnetically responsive beads. The apparatuses and methods of the invention provide for rapid time to result and optimum detection of an analyte in an immunoassay.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: September 18, 2018
    Assignee: ADVANCED LIQUID LOGIC, INC.
    Inventors: Vamsee K. Pamula, Michael G. Pollack, Ramakrishna Sista, Arjun Sudarsan
  • Patent number: 10077462
    Abstract: A method and microfluidic device useful for isolating microbes from a blood sample which includes introducing the blood sample into the sample inlet of a spiral microfluidic device; and introducing a second fluid into the sheath inlet of the microfluidic device, wherein the spiral channel terminates in a microbe outlet and a waste outlet, and wherein the spiral channel includes a length, height, and a width that define an aspect ratio adapted to isolate any microbes present in the sample along a first portion of the spiral channel terminating at the microbe outlet, and to isolate red blood cells and leukocytes along a second portion of the spiral channel terminating at the waste outlet; and collecting the microbes from the microbe outlet, thereby isolating the microbes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 18, 2018
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Han Wei Hou, Jongyoon Han, Roby Bhattacharyya, Deb Hung
  • Patent number: 10058864
    Abstract: A microfluidic structure in which a plurality of chambers arranged at different positions are connected in parallel and into which a fixed amount of fluid may be efficiently distributed without using a separate driving source, and a microfluidic device having the same. The microfluidic device includes a platform having a center of rotation and including at least one microfluidic structure. The microfluidic structure includes a sample supply chamber configured to accommodate a sample, a plurality of first chambers arranged in a circumferential direction of the platform at different distances from the center of rotation of the platform, and a plurality of siphon channels, each of the siphon channels being connected to a corresponding one of the first chambers.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: August 28, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: Beom Seok Lee
  • Patent number: 10058861
    Abstract: A technique relates to a fluidic cell configured to hold a nanofluidic chip. A first plate is configured to hold the nanofluidic chip. A second plate is configured to fit on top of the first plate, such that the nanofluidic chip is held in place. The second plate has at least one first port and at least one second port. The second plate has an entrance hole configured to communicate with an inlet hole of the nanofluidic chip. The second port is angled above the first port, such that the first port and second port intersect to form a junction. The second port is formed to have a line-of-sight to the entrance hole, such that the second port is configured to receive input for extracting air trapped at a vicinity of the entrance hole.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: August 28, 2018
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Michael A. Pereira, Joshua T. Smith, Benjamin H. Wunsch
  • Patent number: 10048248
    Abstract: A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: August 14, 2018
    Assignee: Abbott Point of Care, Inc.
    Inventors: Min Xie, Stephen C. Wardlaw
  • Patent number: 10048281
    Abstract: The present invention relates to analytical testing devices comprising segmented fluidics and methods for assaying coagulation in a fluid sample received within the segmented fluidics. For example, the present invention may be directed to sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region. The sample analysis cartridge further includes a pump configured to independently mix the first segment in the second conduit and the second segment in the third conduit, and independently position the first segment over the first sensor region and position the second segment over the second sensor region.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: August 14, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Katrina Petronilla Di Tullio, Jay Kendall Taylor, John Lewis Emerson Campbell, Caglar Elbuken, Shelia Diane Ball, Noam Saul Lightstone
  • Patent number: 10048282
    Abstract: The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: August 14, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Katrina Petronilla Di Tullio, Jay Kendall Taylor, Niko Daniel Lee-Yow, Sheila Diane Ball, John Lewis Emerson Campbell
  • Patent number: 10031115
    Abstract: In this system, the carbon component of atmospheric particulate matter (PM2.5) is measured by: heating a sample in a first oven under such conditions as to fractionate the carbon component into carbon fractions; completely converting each carbon fraction into carbon dioxide gas in a second oven; and then measuring the amount of carbon dioxide gas in the carbon fraction precisely. In the system, the problem that a TCD detector cannot measure a low-concentration fraction is solved by using a combustion gas in a non-diluted state, though a combustion gas diluted 150-fold is used in a conventional elemental analyzer. Thus, the present invention develops an international standard instrument in which one standard sample is used and which enables simple standardized measuring acceptable to The International System of Units (SI).
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: July 24, 2018
    Inventor: Ayako Sato
  • Patent number: 10019694
    Abstract: An inventory tracking system to determine the location of an article labeled with an RFID tag in a pocket of a container having a plurality of pockets. The system includes an antenna device that transmits a radiation beam into a pocket to read data from tagged articles. The antenna device includes a first antenna that transmits a beam at the pocket and a second antenna co-located with the first antenna. The second antenna transmits a beam with a predetermined null area oriented to overlap the first antenna's beam at the pocket. In another embodiment, the antenna device includes an antenna that transmits a beam through an antenna gateway device having openings switchable to operable or inoperable states aligned with each pocket. An RFID reader receives the read data from responding tagged articles, and a processor uses the read data to determine whether an article is in a particular pocket.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: July 10, 2018
    Assignee: MEPS Real-Time, Inc.
    Inventor: Paul M. Elizondo, II
  • Patent number: 10004401
    Abstract: A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: June 26, 2018
    Assignee: CELLVIEW IMAGING INC.
    Inventor: Ivana Ledesma
  • Patent number: 10004435
    Abstract: “Zero-click” viewing of sensor data without any user input is provided. A display with sensor data may be “always on,” and may enable discrete viewing of sensor data without significant user hassle. Also, a system may be configured to display only current data, and/or to display the most current data for only a set interval. Also, one device in a continuous analyte monitoring system may be designated as a primary device, or hub, for receiving sensor data, and may control the flow of information and/or alerts to other devices in the system. Sensor data and/or alerts may be sent to a hierarchy of devices and/or persons in a designated order.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: June 26, 2018
    Assignee: DexCom, Inc.
    Inventors: Shawn Larvenz, Katherine Yerre Koehler, Apurv Ullas Kamath, Rian Draeger, Subrai G. Pai
  • Patent number: 10006926
    Abstract: A specimen inspection apparatus into which a specimen transporting apparatus is inserted, the specimen inspection apparatus including: a platform including an upper plate and a lower plate disposed to face each other and to be spaced apart from each other by a predetermined distance; an injection part provided in the upper plate, a front end of the specimen transporting apparatus being inserted into the injection part; an introduction part connected to the injection part and provided between the upper and lower plate; and a plurality of stepped parts provided in the introduction part.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: June 26, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Young-goun Lee, Jung-ki Min, Jong-gun Lee, Hyun-ju Jung
  • Patent number: 10001456
    Abstract: Methods and systems for separating and/or quantifying peptides using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of one or more peptides, for example, peptides that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), by complexing the peptides with a metal cation (e.g., Ca2+) prior to DMS. In some aspects, the present teachings can prevent proton stripping from ionized peptides that can occur in DMS to prevent unintended and/or undesirable alterations to the peptide's charge state distribution.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: June 19, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: John L Campbell, Yves LeBlanc, Chang Liu
  • Patent number: 9989545
    Abstract: There is described an apparatus for depositing and retrieving large volumes of test tubes in/from a warehouse, comprising an input/output module of a first and a second container with a plurality of test tubes, a multiple pick up device of test tubes, a single pick up device of test tubes, a first and second station for the provisional allocation of said containers and a motorized traveling lift able to carry said first and second container simultaneously on two distinct coplanar locations.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: June 5, 2018
    Assignee: INPECO HOLDING LTD.
    Inventor: Gianandrea Pedrazzini
  • Patent number: 9958466
    Abstract: Embodiments disclosed herein relate to methods and systems for performing automated assays, and particularly to performing sequential assays on a sample on an automated instrument.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: May 1, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Celine Roger Dalbert, Joel Daniel Krayer, Adam Bruce Steel, Denis Roy
  • Patent number: 9937492
    Abstract: A method of processing a liquid sample containing an initial quantity of nucleic acids that involves providing a plastic, disposable laboratory implement having at least one transparent wall segment made of a polypropylene mixed with an amount of a clarifier additive that is at least twice as high as is necessary to obtain transparency in the polypropylene, wherein the transparent wall segment exhibits a surface gloss greater than 160 as measured per DIN 67530 at an angle of 60°, bringing the liquid sample into contact with the at least one transparent wall segment and removing the liquid sample from the at least transparent wall segment, wherein the nucleic acid adsorption ratio for the transparent wall segment is less than 3 (wt/wt) relative to relative to the initial quantity of nucleic acids in the liquid sample.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: April 10, 2018
    Assignee: EPPENDORF AG
    Inventor: Christian Taesler
  • Patent number: 9933340
    Abstract: A method for controlled movement of magnetic carriers in a sample volume for performing immunoassays under weightless or reduced-weight conditions, wherein the magnetic carriers are moved inside the sample volume by means of permanent magnets movably arranged relative to at least one spatial axis of the sample volume.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: April 3, 2018
    Assignee: Airbus DS GmbH
    Inventors: Peter Kern, Herbert Backes
  • Patent number: 9927452
    Abstract: The present invention provides a pipette assembly and a liquid handling element employing such a pipette assembly for filling containers. The pipette assembly comprises a biasing member that prevents the containers from being displaced vertically upon withdrawal of the pipette assembly from the containers.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: March 27, 2018
    Assignee: RAI Strategic Holdings, Inc.
    Inventors: Nicholas Harrison Watson, Van Edward Key
  • Patent number: 9909975
    Abstract: A device configured for rotation about an axis of rotation to drive liquid flow within the device. The device includes a detection chamber having opposed first second ends and two optical features defining an optical path through the detection chamber, between the first and second ends. The detection chamber includes a first liquid inlet disposed at the first end on a first side of the optical path, a first liquid outlet disposed at the second end of the detection chamber on the first side of the optical path and a second liquid outlet disposed at the second end of the detection chamber on a second side of the optical path. The first side of the optical path is radially outwards of the second side of the optical path.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: March 6, 2018
    Assignee: Biosurfit, S.A.
    Inventors: Nuno Alexandre Esteves Reis, Tania Moura Pires De Andrade Tenreiro, Miguel Joao Marques Barreiros
  • Patent number: 9896725
    Abstract: A method for detecting presence of a macromolecule of interest in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical characteristics (e.g., impedance) of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing the macromolecule of interest or free of the macromolecule at the first frequency. The presence of the macromolecule in the test droplet is thus determined based on the comparison.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: February 20, 2018
    Assignee: The Regents of the University of California Corporation
    Inventors: Abraham P. Lee, Javier Lopez-Prieto, Robert Lin, Melinda Simon
  • Patent number: 9885701
    Abstract: A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: February 6, 2018
    Assignee: Abbott Point of Care, Inc.
    Inventors: Min Xie, Stephen C. Wardlaw
  • Patent number: 9823196
    Abstract: The present invention relates to DNA sequencing with reagent cycling on the wiregrid. The sequencing approach suggested with which allows to use a single fluid with no washing steps. Based on strong optical confinement and of excitation light and of cleavage light, the sequencing reaction can be read-out without washing the surface. Stepwise sequencing is achieved by using nucleotides with optically cleavable blocking moietys. After read-out the built in nucleotide is deblocked by cleavage light through the same substrate. This ensures that only bound nucleotides will be unblocked.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: November 21, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Reinhold Wimberger-Friedl, Johan Lub, Pieter Jan Van Der Zaag
  • Patent number: 9809904
    Abstract: In some embodiments, methods of recovering a sequence-verified target nucleic acid are provided. In some embodiments, such methods may include tagging each member of a nucleic acid library with a set of adaptor sequences; sequencing the tagged members of the nucleic acid library; and recovering the sequence-verified target nucleic acid from the tagged and sequenced members of the nucleic acid library using a dial-out selection method. In certain embodiments, the members of the nucleic acid library may be tagged with a second set of adaptor sequences.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jay Shendure, Jerrod Schwartz, Jacob Kitzman, Rupali Patwardhan, Joseph Hiatt
  • Patent number: 9733238
    Abstract: A measurement chip (100) is disclosed for use with a microfluidic resistance network (20) comprising a microfluidic sample preparation stage (34, 38), a sample outlet (42) and a waste outlet (44) both in fluidic communication with said preparation stage. The measurement chip comprises a sample channel (104) for receiving a sample from said sample outlet (42), the sample channel comprising measurement means (120, 130) and having a first fluidic resistance; and a waste channel (114) for receiving a waste stream from said waste outlet (44) and having a second fluidic resistance.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: August 15, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Steven Charles Deane
  • Patent number: 9726605
    Abstract: The invention is directed to a fluorescence immunochromatography method carried out by illuminating a fluorescent substance in a membrane with excitation light and detecting fluorescence emitted from the fluorescent substance, by applying a sample to a test strip having a membrane and a transparent film attached to the surface of the membrane, wherein the transparent film satisfies Formula (1) Formula (1) nFf>nWf (nFf: refractive index of transparent film at wavelength ?f of the fluorescence) (nWf: refractive index of analyte liquid at wavelength ?f of the fluorescence), and wherein the membrane contains a fluorescent labeling reagent which binds to target substance contained in the sample; binding the fluorescent labeling reagent to the target substance; immobilizing the fluorescent labeling reagent bound to the target substance in the membrane; detecting the presence of target substance.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 8, 2017
    Assignee: FURUKAWA ELECTRIC CO., LTD.
    Inventors: Hideki Aizawa, Michio Ohkubo
  • Patent number: 9708180
    Abstract: A MEMS device, a method of making a MEMS device and a system of a MEMS device are shown. In one embodiment, a MEMS device includes a first polymer layer, a MEMS substrate disposed on the first polymer layer and a MEMS structure supported by the MEMS substrate. The MEMS device further includes a first opening disposed in the MEMS substrate and a second opening disposed in the first polymer layer.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: July 18, 2017
    Assignee: Infineon Technologies AG
    Inventor: Alfons Dehe
  • Patent number: 9707557
    Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: July 18, 2017
    Assignee: Cambridge Enterprise Limited
    Inventors: Wolfgang Andreas Bauer, Wilhelm T. S. Huck, Martin Fischlechner
  • Patent number: 9683937
    Abstract: An imager may include an array of pixels formed on a substrate. A chemisorption layer such as a planar chemisorption layer may be deposited over the array of pixels. The chemisorption layer may include active sites that bond with anchoring molecules. The anchoring molecules may be bonded to the planar chemisorption layer in only localized regions each covering a respective pixel of the array of pixels. The image sensor may include a photoresist layer that covers the chemisorption layer. Openings in the photoresist layer may define the boundaries of the localized regions. The anchoring molecules may be bonded only with the chemisorption layer without bonding to the photoresist layer. The anchoring molecules may serve to bond with analyte molecules. By forming the anchoring molecules within only localized regions centered over respective pixels, spatial resolution of the imager when imaging the analyte molecules may be improved.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: June 20, 2017
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventor: Brian Vaartstra