Analyzer, Structured Indicator, Or Manipulative Laboratory Device Patents (Class 422/50)
  • Patent number: 11913966
    Abstract: When an automatic analysis apparatus has a mechanism that performs an operation of an arcuate trajectory to access a plurality of positions arranged on a straight line, an arc and a straight line cannot coincide with each other. Thus position adjustment is required to minimize the deviation between the arc and the straight line. An automatic analysis apparatus according to the invention includes a reagent disk which accommodates a plurality of reagent bottles in each of which a plurality of suction ports are arranged along a center line, and which rotates around a central axis to transport a reagent bottle to a desired position; and a reagent dispensing mechanism which rotates around a rotation axis to suck a reagent from the reagent bottle at a predetermined suction position on the reagent disk, in which the reagent disk is provided with, at least one mounting position of the reagent bottle on the reagent disk, first and second marks sandwiching the mounting position of the reagent bottle.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: February 27, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Susumu Sakairi, Takenori Okusa
  • Patent number: 11902896
    Abstract: The present disclosure provides a method for managing a sleep-mode of an electronic device that includes a processor, a memory and a communication interface configured to enable communication with a sleep-client device; the electronic device being arranged to enter the sleep-mode in predetermined circumstances to reduce power consumption; the method comprising the steps of: the electronic device modifying a value of a memory location associated with the communication interface; and the sleep-client device, reading a value of the memory location associated with the communication interface prior to transmitting data to the electronic device via the communication interface; wherein the memory location is representative of the availability of the electronic device to receive data via the communication interface.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: February 13, 2024
    Assignee: Morse Micro Pty. LTD.
    Inventor: Harith Hamed Mohammed Al-Haboubi
  • Patent number: 11899014
    Abstract: The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: February 13, 2024
    Inventors: Virginia Wood Cornish, Nili Ostrov, Miguel Jimenez, Sonja Billerbeck
  • Patent number: 11892811
    Abstract: An apparatus for aggregation of water condition at household appliances comprises a communication interface and a controller. The communication interface is configured to send a reporting message indicative of data collected by at least one appliance to a central server. The controller is configured to receive an analysis message from the central server. The analysis message indicates a condition of water from the at least one appliance or a condition of water in a geographic area associated with the at least one appliance. The controller is configured to provide an alert in response to the analysis message.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: February 6, 2024
    Assignee: Kohler Co.
    Inventors: Rafael Rexach, Nona Beining, Alyssa Wilterdink, Shawn Booth, Thomas E. Lilly, Doug Diemel, Jr., Leslie Petch
  • Patent number: 11892421
    Abstract: An electrical stability testing device includes a cup configured to receive a fluid sample. The testing device also includes a pair of electrodes positioned at least partially within the cup. The electrodes are spaced apart from one another by a predetermined gap. The electrodes are configured to have the fluid sample positioned within the predetermined gap while performing an ES test on the fluid sample in the cup. The testing device also includes a wiper positioned at least partially within the cup. The wiper is configured to pass between the electrodes after the ES test has concluded. A width of the wiper is greater than the predetermined gap between the electrodes. The wiper is configured to deform as the wiper passes through the predetermined gap such that the width becomes substantially equal to the predetermined gap and sides of the wiper contact ends of the electrodes to clean the electrodes.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: February 6, 2024
    Inventors: Timothy Lesko, Jerry Thomas Connaughton, Zakhar Chizhov, Kenneth Slater, Bojan Mitric, Mauricio Tassano
  • Patent number: 11875017
    Abstract: Provided are a system and method that use machine learning to recommend adjustments to digital documents that are included within a report managed by a software application. The system may also provide a trend analysis as part of the recommendation. In one example, the method may include detecting a request to open a digital document from a user via a user interface, populating the user interface with content from the digital document and executing a machine learning model on values within the digital document to identify a value among the values that is to be adjusted to a different value based on previous adjustments by the user to previous reports, activating a user interface element associated with the identified value within the user interface, and in response to a selection of the user interface element, instantiating a display of the different value on the user interface.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: January 16, 2024
    Assignee: SAP SE
    Inventors: Mohd Danish Imam, Ajay Krishna Uniyal, Shivendra Kumar Mathur, Kumar Priyam, Harish Sivakumaran
  • Patent number: 11846281
    Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: December 19, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventor: Robert A Yuan
  • Patent number: 11808646
    Abstract: Sensors that include carbon nanotubes, and articles that include the sensors. The sensors may include a buckypaper. The sensors may be flexible. Methods of making sensors, which may include printing an electrode on a substrate. The printing of an electrode may be achieved with an inkjet printer.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: November 7, 2023
    Assignees: The Florida State University Research Foundation, Inc., Institut National Des Sciences Appliquees De Lyon
    Inventors: Joshua H. Degraff, Pierre-Jean Cottinet, Zhiyong Liang
  • Patent number: 11802882
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 31, 2023
    Assignee: Labrador Diagnostics LLC
    Inventors: Ian Gibbons, Shaunak Roy, Edmond Ku
  • Patent number: 11801506
    Abstract: A fluid ejection system, in an example, includes at least one nozzle of at least one die from which a fluid is ejected and at least one nanowell at which the at least one nozzle ejects an amount of fluid. A method of dispensing a fluid, in an example, includes addressing at least one nanowell with at least one nozzle of at least one die, and depositing a fluid in the nanowell with the at least one nozzle.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: October 31, 2023
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Jeffrey A. Nielsen, Christie Dudenhoefer, Kenneth Ward
  • Patent number: 11779248
    Abstract: Methods and devices to detect analyte in body fluid are provided. Embodiments include positioning an analyte sensor in fluid contact with an analyte, detecting an attenuation in a signal from an analyte sensor after positioning during a predetermined time period, categorizing the detected attenuation in the analyte sensor signal based, at least in part, on one or more characteristics of the signal, performing signal processing to generate a reportable data associated with the detected analyte sensor signal during the predetermined time period, managing if and when to request additional reference signal measurements, and managing if and when to temporarily not display results.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: October 10, 2023
    Inventors: Wesley Scott Harper, Timothy Christian Dunn, Erwin Satrya Budiman, Kenneth J. Doniger, Gary Alan Hayter
  • Patent number: 11761940
    Abstract: A computer system including sensor technology for detecting environmental pollution levels in a water source and alerting users in real-time of the environmental pollution levels within the water source is provided. The computer system may be configured to receive pollution data from at least one sensor, analyze the received pollution data, and determine a level of environmental pollution in the water source based upon the analysis. The computer system may be also configured to determine, based upon the analysis of the pollution data, whether the water source is polluted, and generate an alert including information of the polluted water source. The computer system is further configured to generate a user list including at least one user of the water source, and transmit the alert to one or more client devices associated with the at least one user to notify the at least one user that the water source is polluted.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: September 19, 2023
    Assignee: State Farm Mutual Automobile Insurance Company
    Inventors: Matthew Megyese, Sarah Ann Lockenvitz, Paul Bates, Nicholas Carmelo Marotta, Cathy Jo Roth, Austin Rowley, Jared Wheet
  • Patent number: 11754574
    Abstract: The present disclosure relates to a red blood cell (RBC) solution comprising ethylenediaminetetraacetic acid (EDTA) and methods for making and using the same. The solution can comprise EDTA at a concentration from 3-5 g/L, including 4 g/L. Well plates prepared using the solution can provide a decreased rate of false positive results in automated immunoassays for detecting RBC antibodies in a patient sample.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: September 12, 2023
    Assignee: IMMUCOR, INC.
    Inventors: Mortimer Alzona, Bryan Marshall, Elizabeth Cope, Margot Borgel, Teresa Welch
  • Patent number: 11738341
    Abstract: The present disclosure is directed to a dispensing system for providing a preset small volume of liquid ?200 ?l into a filling area of a microfluidic sample carrier comprising at least one flow channel, the system including, inter alia, at least one interface unit provided for each flow channel of the microfluidic sample carrier, with each interface unit comprising an injector with an injection channel, wherein the cross section of an outlet part of the injection channel is larger than a cross section of an inlet part of the injection channel and of the middle part of the injection channel. Furthermore, the present disclosure relates to a respective microfluidic sample carrier sealing system and to a respective method of dispensing sealing liquid into a microfluidic sample carrier.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: August 29, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jenny Dittus, Tobias Walz, Andreas Hecht, Jubin Kashef, Volker Barenthin
  • Patent number: 11733258
    Abstract: A nucleic acid extracting device includes a reagent containing unit, a mixing unit, and a flow channel unit. The reagent containing unit contains a specimen, a magnetic bead, and a reagent for extracting. The mixing unit includes a mixing chamber and a stirring assembly. The mixing chamber includes a chamber portion and a tube portion. The stirring assembly includes a main body and an extension. The main body is provided in the chamber portion. The tube portion connects the chamber portion. And the extension connects the main body and extends into the tube portion. The extension and an inner wall of the tube portion have first and second gaps therebetween respectively along first and second directions of the tube portion. The first gap is less than the second gap. The flow channel unit is connected between the reagent containing unit and the mixing unit.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: August 22, 2023
    Assignee: Industrial Technology Research Institute
    Inventors: Chih-Wen Yang, Ruey-Shyan Hong, Tzu-Hui Wu, Ting-Hsuan Chen
  • Patent number: 11714798
    Abstract: A data analysis system is provided in the invention. The data analysis system includes a storage device, a field-data-description-file generating module, and a general data readiness analysis module. The storage device stores a plurality of raw data. The field-data-description-file generating module generates the field-data-description files corresponding to the raw data. The general data readiness analysis module obtains a score of the consistency indicator of the raw data according to the field-data-description files. The general data readiness analysis module obtains the data of the category which needs to be analyzed from the raw data according to the category of each field-data-description file. The general data analysis module obtains the score of the completeness indicator, the score of the accuracy indicator, the score of the validity indicator, and the score of the compaction indicator which all correspond to the data of the category which needs to be analyzed.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: August 1, 2023
    Inventors: Ju-Hsin Kung, Chin-Wei Chang, Sheng-Hua Chen
  • Patent number: 11713479
    Abstract: A method for determining whether a test sample contains a phytopathogenic fungus, which includes (a) putting the test sample on a front surface of a substrate having a through hole; the substrate having a cellulose film on the back surface thereof; the through hole has a cross-sectional area of not less than 7.065 square micrometers and not more than 19.625 square micrometers; and the cellulose film has a thickness of not less than 0.5 micrometers and not more than 3.7 micrometers; (b) leaving the test sample at rest after the step (a); (c) irradiating the cellulose film with ultraviolet light after the step (b); (d) bringing a back surface of the cellulose film into contact with a fungus color reaction reagent after the step (c); and (e) determining that the test sample contains the phytopathogenic fungus, if a color is given to the fungus color reaction reagent.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: August 1, 2023
    Inventors: Yuki Kushida, Yoshitsugu Uriu, Yosifumi Kariatumari
  • Patent number: 11690680
    Abstract: Protective packaging, surgical kits, systems, and methods are described herein for assisting in determining whether a tool is properly installed on a surgical device. The protective packaging retains the tool and has trackable features defined relative to a tool center point of the tool. The trackable features have a predetermined state defined relative to the tool center point and the trackable features are configured to be detectable by a localizer to locate the tool center point. One or more controllers can compare the actual state of the tool center point with an expected state of the tool center point, which is based on an expected condition in which the tool is properly mounted to the surgical device. Based on the comparison, the one or more controllers can determine whether the tool is properly mounted to the surgical device.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: July 4, 2023
    Assignee: MAKO Surgical Corp.
    Inventors: Roberto Montane, Brandt Williams, Seamus Gilhooley, Jonathan Mark Morgan, Mark Palm, Michael Vu
  • Patent number: 11691762
    Abstract: A method and a system for monitoring a mechanical system, the mechanical system including a lubrication system provided with a reservoir containing a lubricating liquid, with a lubrication circuit designed to lubricate the mechanical system, as well as with a particle detection device arranged in the lubrication circuit. The detection device makes it possible, in particular, to count the number of particles flowing through the lubrication circuit and/or the flow rate of the particles. Comparing that number or that flow rate with a first threshold makes it possible to determine a risk of damage affecting the mechanical system and to anticipate the maintenance or reinforced monitoring operations that possibly need to be performed.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: July 4, 2023
    Inventor: Gilles Belhabib
  • Patent number: 11685894
    Abstract: System, including methods and apparatus, for identifying and picking spectrally distinct colonies. In an exemplary method, a filter may be received in an optical path extending from a light source to a grayscale image detector. The filter may be configured to increase an intensity difference between a first type of colony and a spectrally distinct second type of colony. Colonies including both types may be received in the optical path. An image of the colonies may be obtained with the grayscale image detector. At least one of the types of colony may be identified in the image. One or more colonies of the at least one type may be picked robotically.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: June 27, 2023
    Assignee: Molecular Devices, LLC
    Inventors: Timothy Arthur Floto, Alison Amy Glaser, Michael George Youngquist, Fiona Lucy Plows
  • Patent number: 11680954
    Abstract: An automatic assaying system having a multiplex pipette cartridge section in which pipette cartridges are docked. At least one pipette cartridge has a different pipetting characteristic from another corresponding pipette cartridge, the different pipetting characteristic being selectable from a number of different pipetting characteristics. A multiplexing work item holder has an array of work item holder docks that dock corresponding work item holders selectable from pipette trays and pipette tip set racks that define the selectable different pipetting characteristic. One or more of the work item holder docks are indexed to selectably multiplex both the different interchangeable pipette trays and the at least one pipette set rack. A carrier moves the pipette cartridge or a work item holder carriage and a controller selects the at least one pipette tip set rack corresponding to a work item holder dock so as to effect automatic selection of the different pipetting characteristic.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: June 20, 2023
    Assignee: HighRes Biosolutions, Inc.
    Inventor: Ulysses Gilchrist
  • Patent number: 11648559
    Abstract: A variety of devices and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least (i) a filtering stage, (ii) a sheath flow stage for ferrohydrodynamic separation of magnetically labelled white blood cells, and (iii) a focusing stage for marker-independent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (>95%) of the unlabeled rare cells.
    Type: Grant
    Filed: August 4, 2018
    Date of Patent: May 16, 2023
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Leidong Mao
  • Patent number: 11610754
    Abstract: An object of the invention is to provide a charged particle beam device capable of specifying an irradiation position of light on a sample when there is no mechanism for forming an image of backscattered electrons. The charged particle beam device according to the invention determines whether an irradiation position of a primary charged particle beam and an irradiation position of light match based on a difference between a first observation image acquired when the sample is irradiated with only the primary charged particle beam and a second observation image acquired when sample is irradiated with the light in addition to the primary charged particle beam. It is determined whether the irradiation position of the primary charged particle beam and the irradiation position of the light match using the first observation image and a measurement result by a light amount measuring device.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: March 21, 2023
    Inventors: Katsura Takaguchi, Yohei Nakamura, Masahiro Sasajima, Toshihide Agemura, Natsuki Tsuno
  • Patent number: 11604195
    Abstract: A method of analyzing and/or sorting selected cells or other biological components, for example for cell-based therapy, includes sampling a sample with an open end of a probe to obtain a fluid stream with the sample in it. The probe with the open end also has a fluid supply to convey fluid to the open end, and a fluid exhaust to convey the fluid stream away from the open end. The method then includes conveying the fluid stream to a flow cytometer and analyzing the fluid stream by flow cytometry; and/or separating it into at least two components. An apparatus with the probe connected to the flow cytometer may support this method. The method can provide for sampling of multiple samples efficiently, in particular to select cells for cell-based therapies.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: March 14, 2023
    Inventor: Michael Iannotti
  • Patent number: 11604189
    Abstract: A detection device (10), comprising a sample detection layer (1) provided thereon with a detection reagent reacted with an analyte and a result display region (18), wherein the device further comprises a symbol display layer (2) on which an indicator (21) is processed; after the indicator contacts with a gas which can change the color of the indicator, the indicator changes from a first color to a second color.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 14, 2023
    Assignee: LEADWAY (HK) LIMITED
    Inventors: Feng qin Fei, Chunxia Zhang, Tao Shang
  • Patent number: 11559806
    Abstract: The present invention generally relates to the manipulation of species using acoustic waves such as surface acoustic waves. In some aspects, a channel such as a microfluidic channel may be provided having two or more outlets, and acoustic waves applied to species within the channel to determine which outlet the species is directed to. For instance, surface acoustic waves may be applied to a species such as a cell or a particle to deflect it from the channel into a groove or other portion that directs it to a different outlet. In some cases, surprisingly, this deflection of species may be in a different direction than the incident acoustic waves on the channel. Other embodiments of the present invention are generally directed to kits including such systems, techniques for producing such systems, or the like.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: January 24, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Weitz, Warren Lloyd Ung, Thomas Franke
  • Patent number: 11543422
    Abstract: The automatic analysis system comprises an analysis device which introduces sample containers which have been placed at a predetermined placement location into an analysis unit to perform analysis on the samples, and a management device which has a function of transmitting identification information for a sample to said analysis device when an analysis request has been made for that sample. The analysis device comprises a sample information management unit which retains sample identification information transmitted from the management device as analysis-requested sample information and retains identification information for samples which have been analyzed by the analysis unit as analysis-completed sample information.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: January 3, 2023
    Inventor: Kiyohiro Sugiyama
  • Patent number: 11521843
    Abstract: A sample support is a sample support for sample ionization, including: a substrate formed with a plurality of through holes opening to a first surface and a second surface on a side opposite to the first surface; a conductive layer provided not to block the through hole in the first surface; and a reinforcement member disposed inside a part of the plurality of through holes.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: December 6, 2022
    Inventors: Miu Takimoto, Takayuki Ohmura, Masahiro Kotani
  • Patent number: 11517292
    Abstract: An electronic system for non-invasive monitoring of estrogen of a female human comprises a wearable device (1) and a processor (13, 30, 40). The wearable device (1) includes a first sensor system (101) configured to be worn in contact with the skin of the female human and to determine a level of perfusion of the female human. The processor (13, 30, 40) is configured to receive and store the level of perfusion of the female human from the first sensor system (101) for a respective point in time. The processor (13, 30, 40) is further configured to determine a change in the level of perfusion of the female human, using the levels of perfusion of the female human stored for a plurality of respective points in time. Furthermore, the processor (13, 30, 40) is configured to detect a change in estrogen level of the female human based on the change in the level of perfusion of the female human.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: December 6, 2022
    Assignee: FEMTEC HEALTH, INC.
    Inventors: Peter Stein, Brigitte Leeners
  • Patent number: 11506881
    Abstract: A system and method of imaging an object uses a plasmonic layer as a sample holder defining a periodic array of sub-micron structures adjacent the object. The sample holder is exposed to a first portion of light that is transmitted through either the plasmonic layer but not the object, or the plasmonic layer and a first section of the object, and a second portion of the light that is transmitted through the plasmonic layer and at least a second section of the object. The light interacts with at least the plasmonic layer and the first portion of the transmitted light characterizes one or more first surface plasmon resonance peaks and the second portion of the transmitted light characterizes one or more second surface plasmon resonance peaks that are wavelength shifted from the first surface plasmon resonance peaks by the object affecting plasmons propagating within the plasmonic layer.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: November 22, 2022
    Assignee: La Trobe University
    Inventors: Eugeniu Balaur, Brian Abbey
  • Patent number: 11499176
    Abstract: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: November 15, 2022
    Inventor: Don Straus
  • Patent number: 11485877
    Abstract: A structure body includes a base material and a siloxane based molecular membrane formed on the base material by use of an organic compound represented by Formula (1) or Formula (2): wherein any one of R1 to R5 is an amino group, others of R1 to R5 are each independently hydrogen or an alkyl group, R7 to R9 are each independently any one of hydroxy group, alkoxy group, alkyl group, and phenyl group on condition that one or more of R7 to R9 are each independently a hydroxy group or an alkoxy group, and R6 is an alkyl group.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: November 1, 2022
    Inventors: Kei Hayakawa, Hajime Shingai, Akira Nukazuka, Hitoshi Kuno
  • Patent number: 11480567
    Abstract: An apparatus and method to detect disease-specific antigens assists in disease diagnosis. Point-of-care (POC) micro biochip incorporates at least one hydrophilic microchannel for controlled and self-driven flow of body fluid. Metallic nano-interdigitated electrodes disposed within the channels give enhanced sensitivity detection. Microchannel controls flow and amplifies a capillary effect. Electrodes are fabricated on microchannel surface to detect biomolecular interactions. When a sample flows through microchannel, disease-specific antigens from the sample form antigen-antibody complex with antibodies immobilized on electrodes. Antigen-antibody interaction is detected via an electrical change in the biochip's nano circuit. Each electrode may include a different antibody to detect different antigens. Capacitance during antigen-antibody interaction without microfluidic flow is higher than with microfluidic flow due to immobilized antibodies instability on sensing surface caused by shear stress.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: October 25, 2022
    Assignee: New Jersey Institute of Technology
    Inventors: Eon Soo Lee, Bharath Babu Nunna
  • Patent number: 11412961
    Abstract: Provided is a blood glucose measurement device and method. The blood glucose measurement device may determine a blood glucose unit to be provided to a user based on a user input and a region in which the device is positioned, and provide blood glucose data to the user using the determined blood glucose unit through a display.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: August 16, 2022
    Assignee: PHILOSYS CO., LTD.
    Inventor: Young Wook Lee
  • Patent number: 11413355
    Abstract: Disclosed is the use of a gold cluster or a gold cluster-containing substance in the preparation of a drug for preventing and/or treating glaucoma.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: August 16, 2022
    Assignee: Shenzhen Profound-View Pharma Tech Co., Ltd
    Inventor: Taolei Sun
  • Patent number: 11407785
    Abstract: Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: August 9, 2022
    Assignee: Unchained Labs
    Inventors: John Varni, Stephen Lambert, Robert Busacca, Russell Burge
  • Patent number: 11366061
    Abstract: An approach is described that combines distinct properties of a specialized porous nitrocellulose film (PNC) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of PNC that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light. Quantum nanoparticles complement these PNC properties by providing a higher level of emitted light than the fluorescent dyes in common microarray use. Overall, the approach allows for instrument cost savings, reduced imaging time, and the ability to remotely image.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: June 21, 2022
    Assignee: Grace Bio-Labs, Inc.
    Inventors: Jennipher Lyn Grudzien, Michael Albert Shultz, Florian Gene Bell, Charles M. McGrath
  • Patent number: 11360014
    Abstract: A method is disclosed comprising determining a concentration of one or more compounds of a fluid in an industrial water operation in real time. The determining of the concentration of the one or more components comprises contacting an array of sensors of a microelectromechanical system (MEMS) device with a sample of the fluid to provide a sample response indicative of the concentration of the one or more components. The method further provides adjusting or maintaining at least one operating parameter of the industrial water operation based on the concentration of the one or more components of the fluid.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: June 14, 2022
    Assignee: Multi-Chem Group, LLC
    Inventors: Dale E. Jamison, William Walter Shumway, Preston Andrew May, Jay Paul Deville, Troy Francis Davis, Frederick Thomas Brown
  • Patent number: 11325110
    Abstract: The present invention provides a magnetic Fe2O3 nanosphere with PNH surface modification and application thereof in water treatment. First, 2,2-bipyridyl-5,5?-dicarboxylic acid is reacted with thionyl chloride to obtain 2,2-bipyridyl-5,5?-diacid chloride; then 2,2-bipyridyl-5,5?-diacid chloride and 1,4,8,11-tetraazacyclotetradecane react in the presence of triethylamine to obtain a polynitrogen heterocyclic polymer; the polynitrogen heterocyclic polymer is added into an aqueous solution with iron salt to obtain a magnetic Fe2O3 nanosphere with PNH surface modification which has strong light absorption ability, which improves its ability to catalyze in degradation of tetracycline under visible light, so that the pollutants are removed from water.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: May 10, 2022
    Inventors: Jianmei Lu, Qingfeng Xu
  • Patent number: 11300571
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 12, 2022
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
  • Patent number: 11191464
    Abstract: A system and method for preparing a diagnostic fluid sample for use with a fluid assay system. The method comprises the steps of: amplifying the fluid sample to increase the number of cells subject to being tested; drawing a first volume of the fluid sample into a first syringe of a dual-barrel syringe and dispensing the first volume of the fluid sample through a media filter. The method further comprises the steps of placing the bacteria-laced filter into a lysis module; dispensing a first portion of a lysis buffer into the lysis module from the second syringe of the dual-barrel syringe; and dispensing a second portion of the lysis buffer through the media filter into a disposable cartridge of a fluid assay system.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: December 7, 2021
    Assignee: Integrated Nano-Technologies, Inc.
    Inventors: Dennis M. Connolly, Richard S. Murante, Nathaniel E. Wescott
  • Patent number: 11187707
    Abstract: A method for characterizing or quantifying one or more proteins in visible and/or sub-visible particles formed in a sample by detecting the at least one visible or sub-visible particle in the sample, isolating and capturing the at least one visible or sub-visible particle to identify a presence of a protein, and using a mass spectrometer to characterize the protein.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: November 30, 2021
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Xiaobin Xu
  • Patent number: 11169167
    Abstract: A sample analysis substrate rotatable to transfer a liquid includes a substrate including a rotation shaft, a first holding chamber, a second holding chamber holding a first liquid discharged from the first holding chamber, a main chamber holding the first liquid discharged from the second holding chamber, a first flow path with the first holding chamber and the second holding chamber, and a second flow path having a third opening and a fourth opening respectively connected with the second holding chamber and the main chamber. The first holding chamber includes a portion farther from the rotation shaft than a position thereof connected with the first opening. The second holding chamber includes a portion farther from the rotation shaft than a position thereof connected with the second opening. In the second flow path, the third opening is closer to the rotation shaft than the fourth opening.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 9, 2021
    Inventors: Fusatoshi Okamoto, Masahiro Johno
  • Patent number: 11141729
    Abstract: An object focuser may include a substrate, a sample fluid passage supported by the substrate, a first inertial pump supported by the substrate to pump a sample fluid entraining an object through the sample fluid passage, a first sheath fluid passage, a second inertial pump supported by the substrate to pump a first sheath fluid through the first sheath fluid passage, a second sheath fluid passage and a second inertial pump supported by the substrate to pump a second sheath fluid through the second sheath fluid passage. The first sheath fluid passage and the second sheath fluid passage are connected to the sample fluid passage at a convergence on opposite sides of the sample fluid passage.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: October 12, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Viktor Shkolnikov, Alexander N. Govyadinov, Pavel Kornilovich
  • Patent number: 11133516
    Abstract: The present teachings provide multi-reformable fuel delivery systems and methods that can deliver, without the use of a liquid pump, any hydrocarbon fuel, i.e., a liquid or gaseous reformable fuel, for example, to at least one of a reformer, a vaporizer, a fuel cell stack, an afterburner and other assemblies and components of a fuel cell unit or system, More specifically, gas pressure can be used to control and deliver gaseous reformable fuels and/or liquid reformable fuels in the delivery systems and methods of the present teachings. The delivery systems and methods also can apply to the delivery of a liquid reactant such as water and gaseous reactants such as an oxygen-containing gas (e.g., air) and steam.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: September 28, 2021
    Assignee: WATT Fuel Cell Corp.
    Inventors: Paul DeWald, Caine Finnerty
  • Patent number: 11112233
    Abstract: Aspects of the subject technology relate to an apparatus for self-mixing particulate-matter sensing using a vertical-cavity surface-emitting laser (VCSEL) with extrinsic photodiodes. The apparatus includes a dual-emitting light source disposed on a first chip and to generate a first light beam and a second light beam. The first light beam illuminates a particulate matter (PM), and a light detector extrinsic to the first chip measures the second light beam and variations of the second light beam and generates a self-mixing signal. The variations of the second light beam are caused by a back-scattered light resulting from back-scattering of the first light beam from the PM. The light detector is coupled to the dual-emitting light source. The direction of the second light beam is opposite to the direction of the first light beam, and the second light beam is directed to a sensitive area of the light detector.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: September 7, 2021
    Assignee: Apple Inc.
    Inventors: Mehmet Mutlu, Michael K. Brown, Wesley S. Smith, Orit A. Shamir, Richard T. Chen, Mark T. Winkler, Miaolei Yan, Richard Yeh
  • Patent number: 11103870
    Abstract: Methods are described herein for isolating clonal populations of cells having a defined genetic modification. The methods are performed, at least in part, in a microfluidic device comprising one or more sequestration pens. The methods include the steps of: maintaining individual cells (or precursors thereof) that have undergone a genomic editing process in corresponding sequestration pens of a microfluidic device; expanding the individual cells into respective clonal populations of cells; and detecting, in one or more cells of each clonal population, the presence of a first nucleic acid sequence that is indicative of the presence of an on-target genome edit in the clonal population of cells. Also described are methods of performing genome editing within a microfluidic device, and compositions comprising one or more clonal populations of cells generated according to the methods disclosed herein.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: August 31, 2021
    Assignee: Berkeley Lights, Inc.
    Inventors: Gregory G. Lavieu, Annamaria Mocciaro, Xiao Guan Radstrom, Jason M. McEwen, Magali Soumillon, J. Tanner Nevill, Volker L. S. Kurz, Patricia A. Dyck, Ravi K. Ramenani
  • Patent number: 11073530
    Abstract: A sample distribution system 1 has a regulator 4 for receiving a pipetting unit 2 that has at least one exchangeable pipette tip 3, wherein the regulator 4 is configured to change the position of the pipetting unit 2 in relation to a base plate 5, and to detect the presence or absence of pipette tips 3 with a sensor unit 12. According to the invention, the sensor unit 12 is a photoelectric sensor, in particular a reflection photoelectric sensor, with a detection range. The sensor unit 12 and the pipetting unit 2 can also move in relation to one another, in order to determine the presence of a pipette tip 3, if the pipette tip is in the detection range of the sensor unit 12.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: July 27, 2021
    Assignee: Integra Biosciences AG
    Inventors: Garry Müller, Andreas Städler
  • Patent number: 11002733
    Abstract: The invention relates to a lateral flow device (10) for taking at least one analyte of interest in a fluid, comprising: a fluid receiving zone (100) for receiving the fluid, comprising a first absorbent material (111) that is capable of collecting the fluid; at least one zone of migration (201) for migration of the fluid, extending between a first end and a second end, each zone of migration including a draining material (211) in fluid continuity with the first absorbent material; at least one fluid reservoir (storage) zone (301) comprising a second absorbent material (311) in contact with the draining material at the level of the second end of each fluid migration zone; the detection means between the receiving zone and the reservoir zone, that provide the ability to determine the presence or absence of the said one or more analyte(s) of interest in the sample; characterised in that at least the one of the said zones of migration further also comprises at least one capture zone (400) that is capable of re
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 11, 2021
    Inventors: Adrien Mombrun, François Berger, Mohamed-Ali Bouamrani, Gary Brandam, Clarence Deffaud, Julien Roux
  • Patent number: 10955380
    Abstract: A nanoscale protein-sensing platform with a non-equilibrium on-off switch that employs dielectrophoretic and hydrodynamic shear forces to overcome these thermodynamic limitations with irreversible kinetics. The detection sensitivity is achieved with complete association of the antibody-antigen-antibody (Ab-Ag-Ab) complex by precisely and rapidly assembling carbon nanotubes (CNT) across two parallel electrodes via sequential DC electrophoresis and dielectrophoresis (DEP), and with single-CNT electron tunneling conductance. The high selectivity is achieved with a critical hydrodynamic shear rate between the activated dissociation shear rates of target and non-target linkers of the aligned CNTs.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 23, 2021
    Assignee: University of Notre Dame du Lac
    Inventors: Hsueh-Chia Chang, Diya Li, Satyajyoti Senapati