Filtering Layer Patents (Class 422/427)
  • Patent number: 10357774
    Abstract: A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 23, 2019
    Assignee: GenMark Diagnostics, Inc.
    Inventor: David Walter Wright
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Publication number: 20150110687
    Abstract: The invention relates to an optical sensor element, comprising indicators (2), selected from luminescence-active means that are of the same type or different, and indicator protectors (1), and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules.
    Type: Application
    Filed: May 29, 2013
    Publication date: April 23, 2015
    Inventors: Dirk Schoenfuss, Claudius-Michael Ortega Schulte
  • Patent number: 8986625
    Abstract: A method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of the hydrogen sulphide by forming a sulphur-containing solid product which is different in color from the solid reagent, and recovering the sulphur-containing solid product. The invention also relates to a device suitable for the implementation of this method.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: March 24, 2015
    Assignee: Total S.A.
    Inventors: Daniel Dessort, Robert Le Van Loï, Nadine Loubere
  • Patent number: 8968677
    Abstract: An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: March 3, 2015
    Assignee: Quantum Design International, Inc.
    Inventors: Ronald T. LaBorde, Nicholas J. Neild
  • Patent number: 8940237
    Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: January 27, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
  • Patent number: 8940234
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: January 27, 2015
    Assignee: Intel Corporation
    Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Patent number: 8916110
    Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 23, 2014
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Patent number: 8911681
    Abstract: A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous-based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 16, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Karen Meloy Goeders, Ning Wei
  • Patent number: 8858884
    Abstract: A sterilization indicator system and method of using the system to determine efficacy of a sterilization process. The system includes a vial having a first compartment containing spores of one or more species of microorganism; a second compartment containing a growth medium with a disaccharide, an oligosaccharide or a polysaccharide in which the vial is free of monosaccharide; an enzyme, capable of acting upon the monosaccharide to yield reaction products and electron transfer, disposed on two or more electrodes adapted to carry an electrical signal resulting from the electron transfer, the pair of electrodes positioned to contact the combined contents of the first compartment and the second compartment during incubation; and an apparatus linked or linkable to the electrodes and adapted to detect and measure the electrical signal resulting from electron transfer when the enzyme acts upon the monosaccharide.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 14, 2014
    Assignee: American Sterilizer Company
    Inventors: Phillip P. Franciskovich, Tricia A. Cregger
  • Patent number: 8747773
    Abstract: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 10, 2014
    Inventor: Maryse Thomas
  • Patent number: 8721990
    Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: May 13, 2014
    Assignee: Alere Switzerland GmbH
    Inventors: Balbir Raj, Saji Eapen, Ezra Linley
  • Patent number: 8722417
    Abstract: An apparatus is provided for sensing an analyte in a fluid.
    Type: Grant
    Filed: January 20, 2007
    Date of Patent: May 13, 2014
    Assignee: Invoy Technologies, L.L.C.
    Inventor: Lubna Ahmad
  • Patent number: 8703494
    Abstract: Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: April 22, 2014
    Assignee: Relia Diagnostic Systems, LLC
    Inventors: William J. Rutter, Jang H. Han, Taewoo Kwon
  • Patent number: 8685745
    Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: April 1, 2014
    Assignee: Polestar Technologies, Inc.
    Inventor: James A. Kane
  • Patent number: 8647589
    Abstract: An object of the invention is to provide various flow cells and a method for manufacturing the same, in which formation of a groove on a substrate and formation of components such as an electrode, auxiliary parts such as a pump are not necessary. The inventive flow cells are capable of realize complicated chemical analysis or synthesis or the like. A channel of a porous member provided on a sample-incompatible substrate is formed; the porous member is composed of an air non-contact region having a network structure and an air contact region covering the air non-contact region and having a lower pore density than the air non-contact region; in which a capillary force to be generated within the porous member is a drive force for pumping a liquid.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 11, 2014
    Assignee: Nippon Telegraph and Telephone Corporation
    Inventors: Tsutomu Horiuchi, Toru Miura, Yuzuru Iwasaki, Jyunichi Takahashi, Katsuyoshi Hayashi, Tsuneyuki Haga, Michiko Seyama, Serge Camou
  • Patent number: 8647575
    Abstract: A blood glucose meter includes a front attachment part to which a test piece is attached, a measurement part for measuring a component of blood collected via a blood guide passage in the test piece, and a monitor for displaying the measurement results obtained by the measurement part. When the device is placed on a horizontal plane by referring to the display face of the monitor as the upper side and the opposite side as the lower side and placing the display face of the monitor upward, the central axis of the test piece extends obliquely downward toward the front side. The blood glucose meter comprises a main part provided with the monitor and a linking part between the main part and the front attachment part. The top face of the linking part is placed roughly parallel to the central axis line and is provided with an ejector lever.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: February 11, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Hirotaka Ohashi
  • Patent number: 8632730
    Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: January 21, 2014
    Assignee: Alverix, Inc.
    Inventors: John F. Petrilla, Daniel B. Roitman
  • Patent number: 8586377
    Abstract: An analytical test element is provided having a surface comprising a chemical detection layer on which a spreading net is disposed, the spreading net being configured to provide for the planar distribution of a liquid sample on the detection layer. The spreading net generally comprises a filament structure coated with a metallic layer that is oxidized at least on one or more surface portions thereof facing the detection layer.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: November 19, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Otto Fuerst, Hans-Peter Haar
  • Patent number: 8557195
    Abstract: A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 15, 2013
    Assignee: Panasonic Corporation
    Inventors: Masaya Nakatani, Makoto Takahashi, Takuya Oka
  • Patent number: 8557198
    Abstract: The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: October 15, 2013
    Assignee: Micronics, Inc.
    Inventors: Patrick Saltsman, Mingchao Shen, Jeffrey M. Houkal, Christy A. Lancaster, C. Frederick Battrell, Bernhard H. Weigl
  • Patent number: 8518342
    Abstract: The present invention relates generally to the field of analysis, for example biological analysis.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: August 27, 2013
    Assignee: Biomerieux
    Inventors: David Mosticone, Pascal Montes, Jean-Claude Raymond, Bruno Colin, Cecile Paris
  • Patent number: 8506903
    Abstract: According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: August 13, 2013
    Assignee: Bayer HealthCare LLC
    Inventor: Rex J. Kuriger
  • Patent number: 8491851
    Abstract: A detection system in a portable assay reader device is enabled or activated after a user applies a manual force to a portion of the reader device, to an object supporting the assay test strip, or to the assay test strip itself. The movement moves a switch from an open state to a closed state. The closed state enables a detection system to monitor one or more test regions in the assay test strip for a reaction. The detection system can include one or more imagers, one or more electrical detectors, one or more magnetic detectors, or one or more optical detectors that monitor the one or more test regions for applicable visible, electrical, magnetic, or optical reactions, respectively. The one or more imagers or detectors transmit data to a processing device to determine the results of a test.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: July 23, 2013
    Assignee: Alverix, Inc.
    Inventors: Brenton A. Baugh, Robert Sean Murphy
  • Patent number: 8449832
    Abstract: A test sensor includes a base, a lid and a channel for receiving a fluid sample. The channel includes a reagent. The test sensor also includes a tip portion extending from at least one of the base and lid. The tip portion prevents or inhibits moisture or contaminants from entering the channel and affecting the reagent. The test sensor further includes a detachable area located adjacent the tip portion. The detachable area is formed so as to assist movement of the tip portion or removal of the tip portion from the remainder of the test sensor. The movement or removal of the tip portion exposes the channel for receiving the fluid sample.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: May 28, 2013
    Assignee: Bayer HealthCare, LLC
    Inventor: Simin Yao
  • Patent number: 8449834
    Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: May 28, 2013
    Assignee: Covidien LP
    Inventors: Rafael Ostrowski, Martin Debreczeny
  • Patent number: 8431087
    Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: April 30, 2013
    Assignee: Covidien LP
    Inventors: Rafael Ostrowski, Martin Debreczeny
  • Patent number: 8431088
    Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: April 30, 2013
    Assignee: Covidien LP
    Inventors: Rafael Ostrowski, Martin Debreczeny
  • Patent number: 8420405
    Abstract: The present disclosure relates to a carbon dioxide detector having a borosilicate substrate. It may also have a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. The carbon dioxide detector may be part of a carbon dioxide detector system also including an air intake operably connected to the housing to allow air to reach the carbon dioxide detector. The carbon dioxide detector may include a borosilicate substrate and a carbon dioxide responsive indicator solution disposed on the borosilicate substrate. This detector may be part of a further system, such as a resuscitation system. The detector may be made by wetting a borosilicate substrate with a carbon dioxide responsive indicator solution and drying the indicator solution to immobilize it and form a dried carbon dioxide detector. It may be used to detect the concentration of carbon dioxide in an air sample by exposing the detector to the sample.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: April 16, 2013
    Assignee: Covidien LP
    Inventors: Rafael Ostrowski, Martin Debreczeny
  • Patent number: 8404479
    Abstract: A simple membrane assay method for detecting or quantitating an analyte in a specimen sample using an assay device equipped with a membrane bound with a capture-substance to capture the analyte, including the steps of filtering a specimen sample using a filter, dropping the filtrate onto said membrane and detecting the presence of the analyte in said specimen sample, as well as a simple membrane assay kit for detecting the presence of an analyte in a specimen sample, including (1) a filter tube, and (2) an assay device equipped with a membrane bound with a capture-substance to capture the analyte. The method or the kit can decrease the occurrence of false positivity and can provide a highly accurate detection of the analyte such as pathogen and antibody in a specimen collected in a medical scene or by an individual.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: March 26, 2013
    Assignee: Denka Seiken Co., Ltd
    Inventors: Hideharu Shimizu, Takeshi Watanabe, Kazuyuki Takizawa, Junji Matsuda, Toshinori Sato
  • Patent number: 8399261
    Abstract: A lateral flow test system together with methods for its use in the detection of one or more analytes, or components, of interest within a sample, such as a biological sample, is provided. The system comprises a liquid formulation of a gold conjugate and a lateral flow assay device that does not include a conjugate pad having conjugate dried thereon.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: March 19, 2013
    Assignee: Inbios International, Inc.
    Inventors: Mazbahul Kabir, Syamal Raychaudhuri, James William Needham, Stanislaw Morkowski
  • Patent number: 8383414
    Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: February 26, 2013
    Assignee: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
  • Patent number: 8377398
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: February 19, 2013
    Assignees: The Board of Regents of The University of Texas System, LabNow, Inc.
    Inventors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas, Patrick E. Rogers
  • Patent number: 8313710
    Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: November 20, 2012
    Assignee: Polestar Technologies, Inc.
    Inventor: James A Kane
  • Patent number: 8313699
    Abstract: The invention relates to a sterilization testing device comprised of a housing with a test chamber, an indicator placed therein, and with a supply for supplying the sterilization medium. According to the invention, the sterilization testing device consists of at least two housing parts that are matched to one another. A supply channel is made inside the housing part and serves to supply the sterilization medium. The supply channel is configured in such a manner that it forms the base body of the test chamber. The test chamber accommodates the indicator that indicates the completion of the sterilization process. Alternatively to this solution, the invention provides a variant, which is very effective with regard to manufacturing and which permits a quantitative statement regarding the sterilization. Webs are formed inside the housing in the at least partially meandering and/or spiral configuration of the supply channel.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: November 20, 2012
    Inventors: Harald Kretschmann, Andreas Rauch
  • Patent number: 8287817
    Abstract: A rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit for receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The delivery unit comprises a label zone permeated with a dried indicator reagent which can be placed in transient fluid communication with the reaction zone of the test unit during the assay procedure. The rapid diagnostic assay system reduces the number of assay reagents, method steps and time required for performance compared to other conventional assays.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: October 16, 2012
    Assignee: Medmira, Inc.
    Inventor: Hermes K. W. Chan
  • Patent number: 8263020
    Abstract: An analytical test element is provided having a surface comprising a chemical detection layer on which a spreading net is disposed, the spreading net being configured to provide for the planar distribution of a liquid sample on the detection layer. The spreading net generally comprises a filament structure coated with a metallic layer that is oxidized at least on one or more surface portions thereof facing the detection layer.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: September 11, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Otto Fuerst, Hans-Peter Haar
  • Patent number: 8252248
    Abstract: The invention relates to an analytical test element for analysis of a liquid sample. The analytical test element may contain a channel which is suitable for capillary transport of the liquid sample and which is provided with an inlet opening for the liquid sample and with an air outlet opening. At least one test field may be arranged in the channel, spaced apart from the inlet opening. The test element comprises a sample application site which is closed with a seal and which is designed in such a way that, when the seal is opened, the sample application site and the inlet opening of the channel are simultaneously open to the outside environment of the test element. The test element can then receive the liquid sample inside the channel via the sample application site and inlet opening, for analysis in the test field. The invention also relates to a test element magazine and to a system for analysis of liquid samples with at least one test element.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: August 28, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Peter Krämer
  • Patent number: 8227258
    Abstract: A liquid delivery apparatus is provided for depositing liquid materials onto prescribed areas. The apparatus includes a sensing and delivery pin and a photo sensor. The apparatus is sized to deliver a droplet of liquid material to the surface of a target area without coming into contact with the target surface. The apparatus is also capable of drawing geometric features, such as lines and grids of liquid material. The photo sensor measures the intensity of light during a processing cycle. Measured reflected-light intensity can be compared in real-time to a reference curve which is based on test process cycles representing the light intensity expected when the process proceeds in the preferred fashion to produce a normal spot having an expected droplet size. The light intensity measurements can also be fitted with a mathematical function such as an asymmetric double sigmoidal curve.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: New Jersey Institute of Technology
    Inventors: Timothy N. Chang, Qiong Shen
  • Patent number: 8211208
    Abstract: A method for purifying polluted air having particle phase pollutants and gaseous phase pollutants is provided. The method comprising: separately purifying and treating particle phase and gaseous phase pollutants present in the air; providing a dust cleaning apparatus, a catalytic filter core and a valve for controlling an airflow path within an air purification apparatus; controlling the airflow path for the air to bypass the catalytic filter core in a way that: if the amount of particle phase pollutants is above a predetermined value, the valve is moved to the open position to enable the air to bypass the catalyst filtering core; if the amount of particle phase pollutants is less than a predetermined value, the valve is moved to the closed position to force the air to pass through the catalyst filtering core.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: July 3, 2012
    Assignee: Akos Advanced Technology Ltd.
    Inventors: Yiu Wai Chan, Sui Chun Law
  • Patent number: 8129195
    Abstract: A method is provided for producing an analytical element comprising at least one test field for analyzing a liquid sample, wherein provision is made for a carrier on which a polymer fabric is arranged. At least one portion of the polymer fabric is irradiated with UV laser light and thereby hydrophobized.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: March 6, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Josef Roeper, Werner Finke, Beate Koschorreck
  • Patent number: 8124025
    Abstract: Articles for testing a coagulation process in whole blood.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: February 28, 2012
    Assignee: Medtronic, Inc.
    Inventors: Jyotsna Ghai, Charlene X. Yuan, Wei Qin, Mark A. Thompson
  • Patent number: 8071048
    Abstract: The invention concerns test elements, in particular diagnostic test elements, for determining the presence or concentration of biological, medical or biologically or medically effective substances including nucleic acids, proteins, viruses, microorganisms and cells, characterized in that these test elements contain nanofibers.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: December 6, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Herbert Harttig
  • Patent number: 8057755
    Abstract: The present application is about a new construction disposition applied to sample collector for the purposes of feces parasitological exams, more precisely to one new construction form which is manufactured with a reduced number of parts, helping with its low cost, since it is a product discharged after its utilization; collector which includes a container which receives the attachment of a cover which contemplates a central conic sector from whose top a cylindrical duct is developed which can be closed by an over-cover or cap; it is predicted a concave filtering element, formed by polyester net or mesh in the order of 220 to 280?, preferably 266?, which represents the same radius of internal bending of the conic portion of the cover, affixed to it by means of fitting or another equivalent mean.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: November 15, 2011
    Inventor: José Carlos Lapenna
  • Patent number: 8038778
    Abstract: An apparatus (10) for purifying polluted air consisting of particle phase pollutants and gaseous phase pollutants, the apparatus (10) comprising: a dust level sensor (23) to measure the amount of particle phase pollutants in the polluted air; a dust removal component (14) to remove the particle phase pollutants from the polluted air; a catalyst filtering core (17) to decompose the gaseous phase pollutants by chemical reaction; a valve (22) for selectively controlling a path of air flow within the apparatus (10) and is movable between an open position and closed position, the valve (22) being positioned downstream from the dust removal component (14); wherein if the amount of particle phase pollutants measured by the dust level sensor (23) is above a predetermined value, the valve (22) is moved to the open position to enable the air to bypass the catalyst filtering core (17); and if the amount of particle phase pollutants measured by the dust level sensor (23) is less than a predetermined value, the valve (22)
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: October 18, 2011
    Assignee: Akos Advanced Technology Ltd.
    Inventors: Yiu Wai Chan, Sui Chun Law
  • Patent number: 8025850
    Abstract: An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can specifically bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The dried indicator reagent delivery unit comprises a label zone permeated with a dried indicator reagent which is capable of being placed in transient fluid communication with the reaction zone of the test unit during the assay procedure.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: September 27, 2011
    Assignee: Medmira Inc.
    Inventor: Hermes K. W. Chan
  • Patent number: 8003407
    Abstract: The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least one analyte in a sample comprises: (1) a chromatographic strip, a sample filter, a fluid-impermeable barrier, and means for providing a mobilizable detectable agent that is capable of binding to the at least one analyte or to the capture agent after capturing the analyte to the chromatographic strip such that the mobilizable detectable agent migrates through the chromatographic strip and contacts sample that has passed through the sample filter and also has migrated through the chromatographic strip. The test strip allows detection with or without quantitation of an analyte in a sample containing whole cells.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: August 23, 2011
    Assignee: Relia Diagnostic Systems, LLC
    Inventors: Siliang Zhou, William Rutter, Ning Liu
  • Patent number: 7972872
    Abstract: This invention provides an immunochromatography detection apparatus exhibiting excellent convenience, sensitivity, and specificity, a detection method therefore, a kit using the same, and a method for producing such apparatus and kit, by constructing a solid-phase support, on which the conditions for the reaction wherein an analyte specifically binds to a labeled reagent containing a ligand that specifically binds to the analyte and those for the reaction wherein a capture reagent specifically binds to a complex of the analyte and the labeled reagent in the immunochromatography detection method are continuously optimized, and the pretreated specimens are optimized for such reactions.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: July 5, 2011
    Assignee: Denka Seiken Co., Ltd.
    Inventors: Ryo Shida, Hiromi Ito
  • Patent number: 6627265
    Abstract: The present invention is directed to a method of and apparatus for forming a coating having at least one fade zone over a substrate. The method and apparatus include positioning a coating composition dispenser above a surface of a substrate with the coating composition dispenser oriented to dispense a coating composition spray generally normal to the surface of the substrate. A gas dispenser is also positioned above the surface of the substrate and adjacent the coating composition dispenser with the gas dispenser oriented to dispense a gas stream generally normal to the surface of the substrate. The coating composition spray and the gas stream are spaced from each other so as to develop an interference effect therebetween adjacent the surface of the substrate. Preferably the substrate is maintained at a temperature which pyrolyzes the coating composition. The interference effect directs the coating composition to deposit over the substrate as a coating having a fade zone.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: September 30, 2003
    Assignee: PPG Industries Ohio, Inc.
    Inventor: Luke A. Kutilek