Test Package Or Kit Patents (Class 422/430)
  • Patent number: 11051641
    Abstract: The invention discloses portable beverage vessel for storing beverage to be consumed by a human, having a beverage container in which the beverage is stored; and an electronic device having a vessel controller, a transmitter and a receiver, said vessel controller being adapted to communicate with a beverage dispenser by exchanging messages using the transmitter and receiver of the electronic device; wherein the vessel controller is adapted to send an identification message to the beverage dispenser, by which the beverage dispenser can identify the portable beverage vessel. The invention also discloses a communicating between the portable beverage vessel and a fluid dispenser and a personal electronic device.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: July 6, 2021
    Inventors: Josef Schucker, Monique Bissen
  • Patent number: 11033903
    Abstract: Pipetting containers, such as reservoirs, reservoir liners, microplates, PCR plates, microtubes and PCR tubes, include anti-vacuum channels on the bottom wall of the receptacle to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels are located on the bottom surface facing upward into the basin that holds liquid samples or reagents. The anti-vacuum channels also lower the required working volume for pipetting and reduce liquid waste.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: June 15, 2021
    Assignee: Integra Biosciences AG
    Inventors: Terrence Kelly, Jonathan Harkins, George Kalmakis, Gary Nelson
  • Patent number: 10967378
    Abstract: The invention relates to a sample collection kit (100) for collecting plant samples, in particular algae samples for biomedical applications, which sample collection kit comprises at least one sample container for holding plant samples, a plurality of sensors, by means of which sample data can be captured, a data-recording apparatus for recording the sample data, an arrangement of tools, which has collection tools designed for harvesting the plant samples and processing tools designed for processing the plant samples, an arrangement of devices, which has auxiliary devices that can be used in the collection, transport, and processing of the plant samples, a container apparatus (70), which is designed to hold the arrangement of tools and the arrangement of devices in isolation from the environment, and identification markings (80), which contain identification data and are applied to the at least one sample container (70) to the collection tools, and to the processing tools.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: April 6, 2021
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e. V.
    Inventor: Heiko Zimmermann
  • Patent number: 10933419
    Abstract: A pipetting reservoir kit includes a base, a disposable liner, and a lid. The disposable liner includes anti-vacuum channels on the bottom wall to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels located on the bottom surface of the liner face upward into the basin that holds liquid samples or reagents. The groupings of anti-vacuum channels are spaced in an array 4.5 mm apart for a 384 pipetting head and 9 mm apart for a 96 pipetting head. The anti-vacuum channels also lower the required working volume for the liner and reduce liquid waste.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: March 2, 2021
    Assignee: Integra Biosciences AG
    Inventors: Terrence Kelly, Jonathan Harkins, George Kalmakis, Gary Nelson
  • Patent number: 10857534
    Abstract: Sample manipulating tools may comprise a handle portion and a tool portion. A sample spreading tool may comprise a head connected to the handle portion by a pivot connection permitting at least pivotal movement of the tool portion with respect to the handle portion. The head may comprise a perimeter section and a bridge section. Another sample spreading tool may comprise a central element and at least two loop segments connected to the central element with each loop segment having a substantially arcuate shape. A sample picking tool may have a loop section forming a reservoir for receiving a liquid sample and a hook portion fixed to the loop section, with a first end fixed to the loop portion and a second end being a free end. A sample scraping tool may comprise a mounting structure to receive a pipette and a scraper structure having a scraping edge.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: December 8, 2020
    Inventor: John L. Sternick
  • Patent number: 10823729
    Abstract: A cassette is disclosed that permits, with an instrument, quantitative analysis to be performed at the moment of sample testing without additional steps to the end user. The cassette includes a calibration strip and a sample strip. The calibration strip contains known quantities of analyte, from which a calibration curve can be created and applied to the analysis of the sample strip. The disclosed cassette can utilize light transmission or light reflectance techniques. The cassette may include a separate wash port for rapid washing of a high background sample. The disclosed cassette may perform diagnostic tests for humans, animals, environmental sample, and/or food samples. In some cases, the disclosed devices and techniques may be used to monitor efficacy of drug therapy and patient compliance with respect to physician-prescribed medication in a point of care setting.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: November 3, 2020
    Assignee: OPTIMUM IMAGING DIAGNOSTICS LLC
    Inventors: Roger Piasio, Andrew Wheeler, Wesley Cowperthwaite
  • Patent number: 10813992
    Abstract: A method for delivering allergens to a pharmacist in a pre-diluted kit form, comprising providing a bulk container of base concentrate antigen containing at least one antigen at a predetermined concentrated level, creating a sequential and more diluted sequence of antigens, providing a plurality of end-use sealable containers that can receive a finite end amount of diluted antigens, dispensing from each of sequential bulk containers a finite end amount of diluted antigens into one of the plurality of end-use sealable containers, wherein the end-use seal containers filled from each of the sequential bulk containers comprises a group of end-use sealable containers associated with each of the sequential bulk containers, sealing each of the end-use containers after diluted antigens are disposed therein, and disposing a select number of the sealed end-use sealable containers from each of the groups of end-use sealable containers into a container comprising a kit.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: October 27, 2020
    Assignee: ROCA Medical Ltd.
    Inventors: James Strader, Jovan Hutton Pulitzer
  • Patent number: 10753951
    Abstract: Disclosed is a method for determining a blood specimen, comprising preparing a first measurement sample by mixing a blood specimen of a subject with a first coagulation time measurement reagent and measuring first coagulation time, preparing a second measurement sample by mixing the blood specimen with a second coagulation time measurement reagent and measuring second coagulation time, and acquiring a value based on the first coagulation time and the second coagulation time, wherein the second coagulation time measurement reagent contains a metal ion and/or normal plasma, and the value is used to determine whether the blood specimen of a subject is a blood specimen containing a lupus anticoagulant or a blood specimen containing a direct anticoagulant.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 25, 2020
    Assignee: SYSMEX CORPORATION
    Inventor: Osamu Kumano
  • Patent number: 10634664
    Abstract: A blood-glucose meter integrated with a biological test-piece tank includes a biological test-piece tank and a blood-glucose meter. The biological test-piece tank has internally a chamber for providing an accommodation room to store a plurality of biological test pieces, a tank opening located at a top thereof to pair a cover so as to form a sealed structure, and a tank bottom located by opposing to the cover. The blood-glucose meter, connected with the tank bottom, has an inserting hole for receiving a biological test piece that carries thereon a biological specimen to be examined for obtaining a corresponding blood-glucose value.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: April 28, 2020
    Assignee: OK BIOTECH CO. LTD.
    Inventors: Chia-Te Lai, An-Yuan Lee
  • Patent number: 10627412
    Abstract: The present invention provides an inhibitor of an autoimmune response to a periodontal bacterial enzymatic degradation product of keratin in gingival epithelium in a mammal having a periodontal bacterium in the oral cavity, containing a substance having affinity to the keratin or a degradation product thereof and/or a substance having affinity to an autoantibody to the degradation product, an agent for the prophylaxis and/or treatment of a periodontal disease and/or a complication thereof; a RANKL expression inhibitor containing a substance having affinity to the keratin or a degradation product thereof; and a method of diagnosing a periodontal disease including detecting the keratin or a degradation product thereof and/or an autoantibody thereto.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: April 21, 2020
    Assignee: KAGOSHIMA UNIVERSITY
    Inventors: Ikuro Maruyama, Teruto Hashiguchi, Salunya Tancharoen, Ko-ichi Kawahara, Kenji Tanaka, Lyang-ja Lee
  • Patent number: 10618907
    Abstract: Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 14, 2020
    Assignee: PROMEGA CORPORATION
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith V. Wood
  • Patent number: 10595768
    Abstract: A prick test kit comprises a bottom tray containing a plurality of wells disposed in an array, wherein each of the wells contains a vial of a small amount of a specific well associated antigen, with each well and associated vial having a different antigen disposed therein, each of the vials having a rubber cap disposed thereon that is sterile and able to be pricked by a needle such that the small amount of antigen can be removed therefrom. A penetrating plate is disposed above the wells and having on the lower surface thereof diametrically opposite from the vials in the wells a plurality of piercing needles, one associated with each of the wells and directed downward there to but not touching any of the files. A separating plate is disposed between the bottom tray and the penetrating plate. A sterile covering is provided for containing the entire assembly.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 24, 2020
    Assignee: ROCA MEDICAL LTD.
    Inventors: James Strader, Jovan Hutton Pulitzer
  • Patent number: 10598651
    Abstract: A sensing system for sensing degradation of a machine fluid is disclosed. The sensing system may comprise a capsule including a dissolvable element. The dissolvable element may be configured to at least partially dissolve when placed in contact with the machine fluid having an acid content indicative of degradation of the machine fluid. The sensing system may further comprise a tracer encapsulated by the capsule. The tracer may be at least partially released from the capsule when the dissolvable element at least partially dissolves.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 24, 2020
    Assignee: Caterpillar Inc.
    Inventors: Philip C. Spengler, Hind Abi-Akar, Jeffrey R. Ries
  • Patent number: 10501718
    Abstract: Provided is an observation apparatus including: a housing that has, in a top face thereof, a transmission window on which a container accommodating cells can be placed and through which light can pass; a camera portion that is accommodated in the housing and that captures observation light coming from the cells irradiated with illumination light emitted from an illumination portion and entering the housing by passing through a bottom face of the container and the transmission window of the housing; and a housing-interior heating portion that is accommodated in the housing and that heats the cells.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 10, 2019
    Assignee: OLYMPUS CORPORATION
    Inventors: Akira Matsushita, Shintaro Takahashi, Masaru Mizunaka, Shinichi Takimoto, Tadashi Hirata, Yohei Tanikawa
  • Patent number: 10488415
    Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 26, 2019
    Assignees: OY MEDIX BIOCHEMICA AB, DENTOGNOSTICS GMBH
    Inventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Päivi Mäntylä, Ismo Råman, Sinikka Tiisala
  • Patent number: 10379045
    Abstract: The present invention provides a label-free sensing chip for identifying a chemical substance, comprising: (a) a transparent substrate comprising a base and first periodic ridges; and (b) a metal layer covering said transparent substrate, comprising second periodic ridges and third periodic ridges, in which said second periodic ridges has a height equal to or greater than the height of the first periodic ridges, and each ridge of the second periodic ridges fits into the space between each ridge of the first periodic ridges, and said third periodic ridges correspondingly located on said first periodic ridges. The present invention also provides a method for identifying a chemical substance by using the foresaid label-free sensing chip.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: August 13, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Pei-Kuen Wei, Kuang-Li Lee
  • Patent number: 10369251
    Abstract: Disclosed is a medical device having a substrate having an exposed surface and a texture over at least part of the exposed surface. The texture includes a plurality of nanofeatures that inhibit bacterial adhesion on the surface and that also inhibit bacterial growth on the surface and have a size range between about 0.01 nanometers and about 1,000 nanometers. The texture can include a plurality of nanofeatures applied thereto such that the texture has a first particle size at a first location, a second particle size at a second location, and a gradient of particle size from the first particle size to the second particle size between the first location and the second location.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: August 6, 2019
    Assignee: Tyber Medical, LLC
    Inventors: Jeffrey Tyber, Rui J. Ferreira, Chris Faresich
  • Patent number: 10330681
    Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 25, 2019
    Assignees: OY MEDIX BIOCHEMICA AB, DENTOGNOSTICS GMBH
    Inventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Päivi Mäntylä, Ismo Råman, Sinikka Tiisala
  • Patent number: 10287618
    Abstract: A composition for monitoring the efficacy of a decontamination process is provided, the composition comprising a cellulose polymer and a predetermined quantity of an adenine nucleotide. A monitoring device comprising a test element with the composition disposed thereon is also provided. The composition and/or monitoring device can be used in a method. The method includes exposing the monitoring device to a decontamination process and subsequently measuring the residual tracer analyte on the monitoring device.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 14, 2019
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Francois Ahimou, RuthAnn R. Duda, G. Marco Bommarito, Timothy J. Nies, Kai Qiu
  • Patent number: 10254289
    Abstract: The invention relates to a method for risk stratification for acute coronary syndrome (ACS), in particular acute myocardial infarction (AMI) and angina pectoris (AP), wherein provasopressin (proAVP) or fragments and partial peptides thereof, in particular copeptin or neurophysin II, is determined by an in vitro diagnosis.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: April 9, 2019
    Assignee: B.R.A.H.M.S. GmbH
    Inventors: Andreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Leong L. Ng
  • Patent number: 10220329
    Abstract: An acid purifier, comprising: a container (1) for an acid to be purified; a heater (2); a condenser (3) including a Peltier semiconductor cooler, a condenser body (600) and a refrigerant temperature sensor; a purified acid liquid collection bottle (4) connected with the condenser; a controller; an integrated liquid level control component (300) for the acid to be purified, connected with the container (1) for the acid to be purified, and arranged in such a way that a liquid level pipe (320), a liquid adding funnel (310) and a waste liquid discharge valve (330) are integrated; and an acid liquid temperature sensor (400, 500) arranged in the acid to be purified.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 5, 2019
    Assignee: AMERLAB SCIENTIFIC LLC
    Inventor: Donghui Hao
  • Patent number: 10221449
    Abstract: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: March 5, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Linda Lee, Sam Woo, Peter Nien-Tung Ma
  • Patent number: 10215760
    Abstract: The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic assays using such biomarkers.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 26, 2019
    Assignee: Hologic, Inc.
    Inventor: Thomas H. Grove
  • Patent number: 10155810
    Abstract: Provided herein are pro-VP antagonists, such as antibodies and antigen-binding portions thereof specific for pro-VP, for identifying and targeting expressing cancer cells. Applicants additionally provide methods of using said compositions, for example to image cancer cells in vivo and in biological samples. The compositions may also be used for treating patients suffering from a provasopressin-expressing cancer. Provasopressin-expressing cancers include neuroendocrine cancer, pancreatic cancer, and prostate cancer.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: December 18, 2018
    Assignee: Woomera Therapeutics
    Inventors: William G. North, Roy H. L. Pang
  • Patent number: 10144967
    Abstract: The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: December 4, 2018
    Assignee: Illumina Cambridge Limited
    Inventor: Nikolai Nikolaevich Romanov
  • Patent number: 10067104
    Abstract: The present invention relates to a hydrogel bead for detecting hydrofluoric acid and a kit comprising the same, and more particularly, to a hydrogel bead capable of detecting hydrofluoric acid using an organometallic ligand compound that reversibly changes color depending on the concentration of hydrofluoric acid when coming into contact with hydrofluoric acid, and to a kit for detecting hydrofluoric acid comprising the same. In an embodiment, a method for preparing a hydrogel bead for detecting hydrofluoric acid comprises the steps of: mixing an organic compound, which contains an aromatic functional group having at least one hydroxyl group bonded thereto, with a solution of a metal-ligand compound that bonds with the organic compound, thereby preparing a mixed solution; dropping the mixed solution onto a gelling agent; and adding coagulating agent to the mixture resulting from the dropping step to form a porous bead.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: September 4, 2018
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY
    Inventors: Sang Yup Lee, Chaemyeong Lee, Min Chul Kim, Jin Young Kwak, Sang Woo Park, Young Jun Lim, Chang Joon Keum
  • Patent number: 9988666
    Abstract: Methods for the identification of inhibitors of botulinum neurotoxins are described. Cells are provided that are genetically engineered to express peptides that act as a substrate for a botulinum neurotoxin and the provide reporting groups. Spacer sequences between the reporting groups serve to optimize energy transfer between the reporting groups. Characterization of the energy transfer-dependent signal prior to and following exposure to a botulinum neurotoxin in the presence of a candidate inhibitor provides a measure of the effectiveness of the candidate inhibitor.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: June 5, 2018
    Assignee: BIOMADISON, INC.
    Inventors: Robert D. Fish, Min Dong
  • Patent number: 9989473
    Abstract: A system is provided for identifying the presence of a target molecule or ion. The system comprises a solid support, and at least one chemical reagent applied to the solid support. Each chemical reagent produces a presumptive color indication that identifies or excludes the presence of a target molecule or ion.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: June 5, 2018
    Inventor: Michael Callahan
  • Patent number: 9968336
    Abstract: A device for capturing a predetermined volume of a predefined portion (e.g. first void) of a liquid flow, comprises an inlet, an outlet, and a guide with an element displaceable in a first position for capturing the first liquid portion in a reservoir, and in a second position for blocking access to the reservoir, and for passing the liquid to the outlet. The displaceable element moves in transverse direction to the liquid flow, and has lifting means. The element may be substantially flat, or tubular with an elliptical cross section. A kit of parts and a method of assembly are also claimed.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: May 15, 2018
    Assignee: NOVOSANIS NV
    Inventors: Pierre Van Damme, Alex Vorsters, Vanessa Vankerckhoven, Stijn Verwulgen, Christiaan Baelus, Lara Biekens, Koen Beyers, Kristof Sorgeloos, Hanne De Bauw
  • Patent number: 9950304
    Abstract: A system for operating parallel reactors includes a plurality of reactor assemblies, each reactor assembly including: a flow-through reactor, a reactor feed line, a reactor effluent line, a primary fluid source, and a flow splitter which is arranged downstream of the primary fluid source and upstream of the reactor assemblies. All passive flow restrictors have an substantially equal resistance to fluid flow. A feed line pressure measurement device and a pressure control arrangement controls backpressure regulators such that the measured feed line pressure becomes substantially the same as a feed line pressure setpoint in the reactor assemblies.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: April 24, 2018
    Assignee: Avantium Technologies B.V.
    Inventor: Roelandus Hendrikus Wilhelmus Moonen
  • Patent number: 9952229
    Abstract: Subject of the present invention are assays and in vitro methods for the prediction of the risk of a subject for contracting metabolic syndrome and/or diabetes mellitus and for diagnosing metabolic syndrome, comprising determining the level of arginine vasopressin pro-hormone or fragments thereof in a sample of a subject.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: April 24, 2018
    Assignees: B.R.A.H.M.S. GmbH, The General Hospital Corporation
    Inventors: Joachim Struck, Andreas Bergmann, Olle Melander, Christopher Newton-Cheh, Thomas Wang
  • Patent number: 9810703
    Abstract: An improved calibration process for a medical testing machine. The machine automatically recognizes that a package of calibration material has been inserted into it, and performs a calibration sequence to ascertain a calibration parameter to be used in performing future tests with the medical testing machine. The calibration package may include machine-readable indicators that the package is to be used for calibration, and of a calibration setpoint of a calibration material in the package. A calibration material may be stored in a lyophilized state in the package, and the medical testing machine may automatically reconstitute the lyophilized material.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: November 7, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Adam Darmstadt, Michael Waite, Theresa Forni
  • Patent number: 9804141
    Abstract: Methods, devices, and systems are disclosed for releasing a sample from a carrier medium. A method of releasing a sample from a carrier medium comprises treating a sample on a carrier medium with a first organic reagent, wherein when the sample contains at least one inorganic salt, the first organic reagent binds to a cation of the inorganic salt to produce both a first volatile compound and an isolated anion of the inorganic salt; treating the sample on the carrier medium with a second organic reagent, wherein the second organic reagent reacts with the isolated anion to produce a second volatile compound; and releasing the treated sample from the carrier medium, wherein when the first and the second volatile compounds are produced, the releasing step releases at least one of the first and second volatile compounds from the carrier medium.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: October 31, 2017
    Assignee: 1st Detect Corporation
    Inventors: Guido Fridolin Verbeck, IV, David Rafferty, James Wylde, Michael Spencer
  • Patent number: 9737549
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: August 22, 2017
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • Patent number: 9714887
    Abstract: A detection method for a substance and a system thereof are provided. The detection method for a substance contained in a sample includes providing a reagent in reaction with the substance to form a chelate; and pressurizing the substance to accumulate the chelate.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: July 25, 2017
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Chi-Wen Kuo, Yu-Kun Hung, Tzu-Sou Chuang
  • Patent number: 9689794
    Abstract: To provide to a method for measuring and examining lithium ions in an aqueous solution of a specimen such as biomaterials or environment samples, by using a lithium reagent composition as a coloration reaction reagent and by visual observing or a simple a colorimeter. The lithium ions measuring method is characterized by contacting the specimen including serum and plasma test sample with an aqueous solution of a lithium reagent composition comprising a tetraphenyl porphyrin compound, a pH regulator and a pH buffer, by irradiating or expose the resulting solution with white light, and by detecting change in color tone by a visual observation or by detecting the sensitivity by a colorimeter.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: June 27, 2017
    Assignee: METALLOGENICS Co., Ltd
    Inventors: Takuya Iwabuchi, Tsugikatsu Odashima, Hiroko Suzuki
  • Patent number: 9642858
    Abstract: A method for treating infection by bacteria in a subject, comprising administering to the subject a therapeutically effective amount of resazurin or a resazurin analog, or a pharmaceutically acceptable salt or ester thereof, wherein the bacteria is selected from at least one of Francisella sp. or Neisseria sp.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: May 9, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Joseph Andrew Horzempa, Dawn Marie Henson, Gerard Joseph Nau
  • Patent number: 9631913
    Abstract: A calibration control device for being coupled to a measuring device such as a caliper, micrometer, or gauge is provided. The calibration control device includes a circuit portion and couples to a coupling feature on the measuring device. A calibration limit portion defines a parameter limit as related to a usage limit for which the measuring device is certified as calibrated. A controller operates a host-side data connection portion of the calibration control device to output measuring data in a first mode when the usage limit is not exceeded, and operates the calibration control device to perform a calibration limit function when the usage limit is exceeded. The calibration limit function may include stopping the output of the measuring data through the host-side data connection or providing an out-of-calibration warning to the host, or the like.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: April 25, 2017
    Assignee: Mitutoyo Corporation
    Inventors: Bruno Lefebvre, Michael Nahum, Kim W. Atherton
  • Patent number: 9588128
    Abstract: The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: March 7, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Jon Klein, Michael L. Merchant, Rosemary Ouseph, Richard A. Ward
  • Patent number: 9528992
    Abstract: Various embodiments of methods and kits are disclosed for detection and/or diagnosis of cancer (e.g., active malignancy) in a subject patient by analyzing a first sample of the subject patient's albumin-containing extracellular fluid (e.g., blood serum). Some embodiments comprise analyzing a second sample of the subject patient's albumin-containing extracellular fluid obtained between 2 and 90 days (e.g., between 5 and 30 days) after the first sample.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: December 27, 2016
    Inventor: Uladzimir A. Murauski
  • Patent number: 9459261
    Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock 70 kDa protein 1, Alpha-1-antitrypsin Neutrophil elastase complex, Stromelysin-1:Metalloproteinase inhibitor 2 complex, 72 kDa type IV collagenase:Metalloproteinase inhibitor 2 complex, Insulin-like growth factor 1 receptor, Myeloid differentiation primary response protein MyD88, Neuronal cell adhesion molecule, and Tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: October 4, 2016
    Assignee: ASTUTE MEDICAL, INC.
    Inventors: Joseph Anderberg, Jeff Gray, Paul McPherson, Kevin Nakamura, James Patrick Kampf
  • Patent number: 9448224
    Abstract: A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: September 20, 2016
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Mohammad A. Kheiri, D. Glenn Purcell
  • Patent number: 9441220
    Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 13, 2016
    Assignee: General Electric Company
    Inventors: Lin Chen, Bing Shang, Klaus Hochleitner, Rong Hou, Yanju Wang
  • Patent number: 9435744
    Abstract: An analyte detection system and method for the detection of one or more analytes in a sample, the analytes selected from the group consisting of explosives, narcotics, gunshot residue, organophosphate reagents, and toxic industrial chemicals, based on a capillary action in a sample card. The sample card includes a housing with at least one cavity made of flexible material, a sample substrate for collecting the sample with a portion of the substrate exposed from outside the housing, at least one test capsule in the cavity and an absorbent pad. The test capsule(s), the sample substrate, and the absorbent pad comprise at least one or more reagents. The test capsule(s) is ruptured with a rupture mechanism upon inserting the sample card into a reader device. The absorbent pad absorbs a liquid from the test capsule and delivers the same to the sample substrate.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: September 6, 2016
    Assignee: RedXDefense, LLC
    Inventors: Arman Ghodousi, Sarah Josepha Toal, Gregory Scott Ericksen, Daniel Douglas Montgomery, Thomas Emory McVeigh, Jacek Kotowicz
  • Patent number: 9435795
    Abstract: This disclosure relates to compositions that enhance the deposition of detectable moieties on tissue samples, methods utilizing these compositions and kits including these compositions. The compositions include a deposition enhancer having a formula where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other than sulfur, and any combination thereof; n is 1-5, an enzyme, a specific binding moiety and a detectable moiety.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: September 6, 2016
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Eric J. May, Adrian E. Murillo, Jerome W. Kosmeder, II
  • Patent number: 9417245
    Abstract: The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A?-Z—B?—B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A? is a linker group or covalent bond; B? is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: August 16, 2016
    Assignee: North Carolina State University
    Inventor: Jonathan S. Lindsey
  • Patent number: 9410185
    Abstract: A method includes providing a container, introducing a substance into the container, and introducing a readily dissolvable film into the container such that the dissolvable film overlies the substance within the container. An alternative method includes providing a container, providing a readily dissolvable film, the film comprising a substance carried by the film, and introducing the film into the container.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: August 9, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: Michael Lizzi, Donald Copertino
  • Patent number: 9395372
    Abstract: The invention relates to methods for coating nanoparticles with a limited amount of a binding partner and nanoparticles obtainable by the methods disclosed. In particular, the invention is of interest, when coating with only a limited amount of protein is desirable.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: July 19, 2016
    Assignee: PHARMADIAGNOSTICS NV
    Inventors: Anne Van Hoonacker, Meike Roskamp, Patrick Englebienne
  • Patent number: 9260739
    Abstract: The present invention relates to a method for the semi-quantitative determination of cariogenic bacteria in a sample of saliva and/or plaque, in which the microorganisms contained in a sample of plaque or saliva are brought into contact with a carbon source that is fermented to acid by the cariogenic bacteria. The microorganisms are then incubated under conditions which make possible selective acid formation by the cariogenic bacteria. The acid formation is then detected by determining the pH at least once within a period of 12 hours after adding the carbon source, wherein the cariogenic bacteria are determined semi-quantitatively in the sample by comparison of the pH with at least one reference value. In addition, the invention provides kits for carrying out such methods.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: February 16, 2016
    Assignee: Ivoclar Vivadent AG
    Inventors: Manuela Bischof, Carlo Bolis, Urs Lendenmann, Volker Rheinberger
  • Patent number: 9164092
    Abstract: The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic assays using such biomarkers.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: October 20, 2015
    Assignee: Hologic, Inc.
    Inventor: Thomas H. Grove