Automatic Analytical Monitor And Control Of Industrial Process Patents (Class 422/62)
  • Patent number: 5976464
    Abstract: An installation for monitoring an apparatus for generating atmospheres. The installation includes a measuring device for measuring at least one parameter representing the actual operation of the apparatus, an evaluator for evaluating the drift of each representative parameter over time and a trigger for triggering an intervention on the apparatus as a function of the drift before values of each representative parameter reach predetermined critical values.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: November 2, 1999
    Assignee: L'Air Liquide, Societe Anonyme pour l'Etude et l'Exploitation des Procedes Georges Claude
    Inventors: Pascale Pourtalet-McSweeny, Philippe Poynot
  • Patent number: 5968452
    Abstract: A system is provided in an exhaust emission sampling system for controlling a flow controller in order to compensate for the effects of changing water vapor content in a diluted sample having a predetermined dilution ratio. A water measuring device such as a relative humidity sensor generates a water vapor signal based on the amount of water vapor in the diluted sample. The water vapor signal is then processed within a control unit to obtain a value for the amount of water in the diluted sample. A control signal is generated by the control unit based on the amount of water vapor, flow rate of the exhaust emissions, and also, on the type of fuel used in the combustion process to control the flow controller which is, preferably, a mass flow controller. A second system is provided in an exhaust emission analyzing system for determining a final amount of pollutants also compensated for the effects of changing water vapor content in the exhaust emissions.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: October 19, 1999
    Inventor: William M. Silvis
  • Patent number: 5961934
    Abstract: A method and apparatus for dynamically controlling the crystallization of proteins including a crystallization chamber or chambers for holding a protein in a salt solution, one or more salt solution chambers, two communication passages respectively coupling the crystallization chamber with each of the salt solution chambers, and transfer mechanisms configured to respectively transfer salt solution between each of the salt solution chambers and the crystallization chamber. The transfer mechanisms are interlocked to maintain the volume of salt solution in the crystallization chamber substantially constant. Salt solution of different concentrations is transferred into and out of the crystallization chamber to adjust the salt concentration in the crystallization chamber to achieve precise control of the crystallization process.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: October 5, 1999
    Assignee: Biospace International Inc.
    Inventors: Leonard Arnowitz, Emanuel Steinberg
  • Patent number: 5958788
    Abstract: A polymer tagged with luminol is provided which enables the fluorescent or chemiluminescent detection of the tagged polymer at low concentrations. The chromophore may be covalently bonded to the polymer backbone without sacrificing the chromophore's fluorescent or chemiluminescent properties. The present invention has been found useful in the treatment and monitoring of industrial waters.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: September 28, 1999
    Assignee: Nalco Chemical Company
    Inventors: Brian S. Johnson, William J. Ward
  • Patent number: 5948368
    Abstract: One sigmoid calibration curve is split into three parts of low concentration region represented by a high degree function, intermediate concentration region represented by an exponential function and high concentration region represented by a high degree function according to the present invention. The boundary condition of the adjacent two functions is set so that the two functions have an equal slope at the boundary point; thereby, regression functions of the calibration curves in respective regions are found. The number of standard samples for finding a calibration curve can be reduced while the calibration curve found is of high accuracy.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: September 7, 1999
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kikuo Hirai, Yoshihiko Makino
  • Patent number: 5942188
    Abstract: An interactive control system for controlling the automatic consolidation of contact lenses in a contact lens product flow, the interactive control system comprises a product line having random variations in product flow. A consolidation buffer receives the products from the product line. A controller initiates consolidation of the random variations in the product flow. The consolidation is preferably performed by at least one stacking cylinder.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: August 24, 1999
    Assignee: Johnson & Johnson Vision Products, Inc.
    Inventors: John Mark Lepper, Russell James Edwards, Daniel Tsu-Fang Wang
  • Patent number: 5938939
    Abstract: Device for separating the liquid and solid constituents of a chemical reaction mixture (1), comprising a metal filtering needle (12) provided with lateral holes (5) and able to pass through polymeric- or rubber-type membranes (3) without the latter losing their gastightness (2), a suction source (7) capable of sucking out a liquid from a closed vessel (8), a liquid evacuation channel (6) and an end-piece (4).
    Type: Grant
    Filed: December 26, 1996
    Date of Patent: August 17, 1999
    Assignee: Rhone-Poulenc Agrochimie
    Inventors: Jean Vial, Jean-Yves Ortholand, Marcel Calleja
  • Patent number: 5939330
    Abstract: The apparatus gathers and prepares liquid samples for analysis for elements or compounds within the liquid samples such as water samples for tritium analysis. This disclosure is further directed toward apparatus and methods for the gathering or collecting of water samples from underground formations penetrated by a borehole, or collecting water samples at varying depths in surface canals, ponds, and the like. The invention is particularly suited for monitoring water in the vicinity of nuclear manufacturing, fabrication and disposal facilities for tritium contamination of ground waters.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: August 17, 1999
    Inventor: Roger Peterson
  • Patent number: 5935863
    Abstract: A method of determining or predicting a value P.sub.x of a property of a feed X to a steam cracking process or yield of said process, which method comprises measuring the absorption D.sub.ix of said material at more than one wavelength in the region 600-2600 nm, comparing signals indicative of said adsorptions or a mathematical function thereof with signals indicative of absorptions D.sub.im or mathematical function thereof at the same wavelength for a number of standards S in a bank for which the said property or yield P is known, and choosing from the bank at least one standard S.sub.m with property P.sub.m said standard having the smallest average value of the absolute difference at each wavelength i between the signal for the material and the signal for the standard S.sub.m to obtain P.sub.x, with averaging of said properties or yields P.sub.m when more than one standard S.sub.m is chosen. If desired the method can be used as such to control the steam cracking process by comparison of P.sub.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: August 10, 1999
    Assignees: BP Chemicals Limited, Naphtachimie S.A.
    Inventors: Bernard Descales, Didier Lambert, Jean-Richard Llinas, Andre Martens, Claude Granzotto
  • Patent number: 5929208
    Abstract: A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: July 27, 1999
    Assignee: Nanogen, Inc.
    Inventors: Michael J. Heller, Eugene Tu
  • Patent number: 5922605
    Abstract: A polymerization apparatus includes a support plate for supporting a workpiece to be polymerized and a hood comprising a light source for guiding light to the workpiece such that the light impinges on at least two sides of the workpiece. The hood is liftable relative to the support plate so as to allow access to the workpiece when in a lifted position. A heat source for heating the workpiece is provided. A control device controls the function of the polymerization apparatus. A method for operating the polymerization apparatus includes the steps of heating the workpiece to a desired temperature after switching on the light source, maintaining the desired temperature for a desired polymerization cycle time period, and subsequently shutting down the light source and the heat source for a final polymerization cycle time period.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: July 13, 1999
    Assignee: Ivoclar AG
    Inventors: Markus Feurstein, Jurgen Mertins
  • Patent number: 5922286
    Abstract: A device for delivering one of a plurality of gases to an apparatus includes at least two valves. Each valve includes a first conduit permanently connected by one end thereof to an associated sampling line and, by another end thereof, to an associated purge line. Each valve includes a second conduit and an actuator which can be switched between bringing the first conduit into communication with the second conduit and a position for isolating the first conduit from the second conduit. At least the second conduit is free of flow-stagnation volumes. The second conduits of the valves are placed in series in a common gas delivery line for delivering gas to the apparatus. The end of the common gas delivery line opposite the apparatus emerges in an associated purge line. Each purge line passes through an element for creating a pressure drop. A use of the device is as a feed for trace impurities analyzer an atmospheric pressure ionization mass spectrometer or a particles analyzer.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: July 13, 1999
    Assignee: L'Air Liquide, Societe Anonyme Pour L'Atude Et L'Exploitation Des Procedes Georges Claude
    Inventors: Jean-Marc Girard, Alain Mail, Yves Marot
  • Patent number: 5900214
    Abstract: A device for delivering one of a plurality of gases to an apparatus includes at least two valves. Each valve includes a first conduit permanently connected by one end thereof to an associated sampling line and, by another end thereof, to an associated purge line. Each valve includes a second conduit and an actuator which can be switched between bringing the first conduit into communication with the second conduit and a position for isolating the first conduit from the second conduit. At least the second conduit is free of flow-stagnation volumes. The second conduits of the valves are placed in series in a common line for delivering gas to the apparatus. The end of the common line opposite the apparatus emerges in an associated purge line. Each purge line passes through an element for creating a pressure drop. A use of the device is as a feed for an ionization mass spectrometer.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: May 4, 1999
    Assignee: L'Air Liquide, Societe Anonyme pour l'Etude et l'Exploitation des Procedes Georges Claude
    Inventors: Jean-Marc Girard, Alain Mail, Yves Marot
  • Patent number: 5891497
    Abstract: An on-line method for the continuous generation of alkali metal salts includes continuously reacting a source of acidity, a liquid having a low pH value, with a source of alkalinity, a liquid having a high pH value, while continuously monitoring an electrical parameter of the resultant in salt which is indicative of its pH value. The monitored value is used to adjust the relative flow rates of the input liquids so as to dynamically maintain the pH value of the resultant salt within a predetermined range. In the apparatus, the input liquids can be continuously supplied to a reacting element and the conductance of the resultant salt monitored for purposes of providing feedback control signals to adjust one or more flow rates.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: April 6, 1999
    Assignee: FBC Industries, Inc.
    Inventors: James E. Bartasis, Barry Edward Carter Williams
  • Patent number: 5888834
    Abstract: An immunoassay plate for an immune complex transfer immunoassay, comprising a well type solid phase and a dip stick type solid phase which can be inserted into said well type solid phase, wherein the dip stick type solid phase is coated with either substance (A) or (B) to be mentioned below and the well type solid phase is coated with the other, remaining substance, and these solid phases are used as the two solid phases to be used for an immune complex transfer immunoassay:(A): a substance having a reactive group which specifically binds to a functional group previously introduced onto a substance, which specifically forms an immune complex with a test substance(B): a substance having a reactive group capable of specifically binding to the test substance in the immune complex, a substance which specifically forms an immune complex with the test substance, or a functional group conjugated in advance with said substance, provided that the moiety which binds to the reactive group of (A) does not bind to the rea
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: March 30, 1999
    Assignees: Sumitomo Pharmaceuticals Company, Limited., Eiji Ishikawa
    Inventors: Eiji Ishikawa, Hidetaka Nakamoto, Satoshi Tanaka
  • Patent number: 5882938
    Abstract: Apparatus and a method for evaluating the contamination over the surface of a substrate for use in manufacturing semiconductor devices, liquid crystal devices and so on, said contamination being caused by contaminants, for instance airborne organic substances or the equivalent in the clean room atmosphere. For evaluation, there is measured with passage of time in the atmosphere having a substantially constant relative humidity the surface resistivity (R) of the substrate 104 by bringing electrodes 106 into close contact with an insulating film as formed on said substrate surface, or a contact angle (.alpha.) of a liquid-drop 207 dropped on the substrate 206. From this measurement, the degree of said contamination is judged by comparing the value of the surface resistivity or contact angle as measured immediately after rinsing the substrate, with the values of the same as measured after exposing the substrate to the objective atmosphere to be evaluated.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: March 16, 1999
    Assignee: Takasago Thermal Engineering Co., Ltd.
    Inventors: Hideto Takahashi, Soichiro Sakata, Katsumi Sato
  • Patent number: 5882598
    Abstract: A conductivity cell for use in determining ionic concentrations in the gap between two semiconductor substrates or wafers. The wafer gap conductivity cell is composed of two flat electrodes separated by a fixed gap. The electrodes are fabricated from wafers of the same type and dimensions used as semiconductor device substrates. All or a portion of the surfaces of the wafer electrodes are coated with a conductive material. The wafer gap conductivity cell is placed in a wafer cassette or other suitable wafer holder, whose other slots are filled with wafers which are to be cleaned or subjected to another fabrication process. The cell can be used to characterize the processes used during the fabrication of semiconductor devices and assist in investigating the effect on the processes of different process vessel designs.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: March 16, 1999
    Assignee: SCP Global Technologies
    Inventors: Paul George Lindquist, Robert Newell Walters
  • Patent number: 5879626
    Abstract: A photoelectric sensor has its own cleaning system which accommodates different possibilities for mounting the photoelectric sensor, so that it is no longer necessary to custom design cleaning systems. The photoelectric sensor includes an optical lens and a cleaning device which cleans the optical lens. The cleaning device further includes a fluid chamber coupled to a source of fluid, and a fluid dispenser in fluid communication with the fluid chamber and disposed adjacent the optical lens. The fluid dispenser is operative to dispense fluid on the optical lens to clean the optical lens. In a preferred embodiment, the cleaning system uses a pulse of air to remove dust from the optical lens of the photoelectric sensor.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: March 9, 1999
    Assignee: Allen-Bradley Company, LLC
    Inventors: Richard L. Watterson, David R. Hagemeier, James J. Boschuetz, Jr.
  • Patent number: 5879948
    Abstract: The present invention relates to a system, apparatus, and process to reduce the oxidized mercury in an exhaust gas to elemental mercury and to prevent its reoxidation by congeneric components in the exhaust gas prior to the photometric measurement of said elemental mercury. In the process, the sample stream flows through a reactor heated to preferably about 800.degree. C. in which a stream of hydrogen is introduced directly into a hot portion thereof. The congeneric oxidized mercury species, i.e, HgCl.sub.2, and HgO are thermally reduced quantitatively to elemental mercury. The hydrogen reacts in situ with oxygen to form water vapor and with chlorine to form hydrochloride gas. The hydrochloride gas is effectively absorbed by the water vapor and consequently prevents the reoxidation of elemental mercury. The concentration of total mercury in a stream can then be determined by the intensity of radiation absorbed by a UV spectrometer.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: March 9, 1999
    Assignee: Tennessee Valley Authority
    Inventors: Vincent J. Van Pelt, Sandra J. Meischen
  • Patent number: 5874046
    Abstract: A sensor system and method are provided that are capable of the real-time detection of target live microorganisms, such as biological warfare agents. The sensor system includes a highly-sensitive, highly-selective sensor cell that comprises a single-stranded oligonucleic acid sequence that is complementary to a portion of the DNA of a target live microorganism, the oligonucleic acid having been modified with the covalent attachment of electron donor and acceptor moieties. In the presence of the targeted microorganism, hybridization occurs between the modified oligonucleic acid and the microorganism's DNA, such that the electron conductance between the electron transfer moieties greatly increases, thereby providing a means of detecting the presence of the target live microorganism.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: February 23, 1999
    Assignee: Raytheon Company
    Inventor: Clifford A. Megerle
  • Patent number: 5874213
    Abstract: Methods are provided for detection and quantitation of mixtures containing target nucleobase sequences using capillary electrophoresis. Peptide nucleic acid oligomers, complementary to the target sequences and preferably having appended detectable labels, are hybridized to the targets. Capillary electrophoresis is then performed, and the detectable label is detected and quantitated.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 23, 1999
    Assignee: Isis Pharmacueticals, Inc.
    Inventors: Lendell L. Cummins, Susan M. Freier, Richard Griffey, G. Susan Srivatsa
  • Patent number: 5869342
    Abstract: A method for determining the amount of residual disinfectant removing agent in a process stream to which the disinfectant removing agent has been added to completely remove a disinfectant residual, comprising the steps of: (a) drawing off a sample of the process stream; (b) mixing an acidic iodate solution and an iodide solution to produce an iodine analyzing agent; (c) adding to the sample the iodine analyzing agent in an amount sufficient to react with the residual disinfectant removing agent and leave an unreacted amount of residual iodine; (d) allowing sufficient time for the iodine to react with the residual disinfectant removing agent; (e) analyzing the sample to determine the amount of residual iodine remaining in the sample, and (f) determining the amount of residual disinfectant removing agent in the sample based on the amount of iodine analyzing agent added and the amount of residual iodine remaining in the sample after reaction.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: February 9, 1999
    Assignee: Wallace & Tiernan
    Inventors: James W. Stannard, Jared K. Bryan, Albert Van Grouw, III
  • Patent number: 5869006
    Abstract: An automatic sample testing machine for testing samples stored in test cards. The machine has a test sample positioning system for moving a tray containing a plurality of test sample cards and fluid receptacles among various stations in the machine. The machine has a diluting station for adding a predetermined quantity of diluent to the receptacles as needed. A pipetting station transfers fluid from one receptacle to another. A vacuum station is provided having a vacuum chamber moveable relative to the tray between upper and lower positions. The chamber cooperates with the tray to make a sealing engagement with the top surface of the tray when it is lowered to the lower position. A vacuum generator supplies vacuum to the chamber. When the vacuum is released from the chamber, the fluid samples are loaded into the cards from the receptacles.
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: February 9, 1999
    Assignee: bio Merieux Vitek, Inc.
    Inventors: Mark Joseph Fanning, Roger James Morris, Ron Robinson, William Ernest Seaton, Daniel Ray Williams, Craig Drager
  • Patent number: 5869240
    Abstract: Integrated methods and apparatus for sequencing or identifying polymers by mass spectrometry with a statistical certainty. The methods involve integrating data obtained by mass spectrometry analysis of a series of polymer fragments and statistically comparing said data with hypothetical data corresponding to known sequences or identities.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: February 9, 1999
    Assignee: PerSeptive Biosystems, Inc.
    Inventor: Dale H. Patterson
  • Patent number: 5866426
    Abstract: A sensor detects when a probe contacts liquid in a container due to a change in frequency of a probe oscillator. The sensor can have its output compared to a reference level to determine the presence or absence of liquid wherein the reference level is changed to follow the output of the detector. In one embodiment, it can be determined that liquid has been contacted when a count has been reached several times in a row (the count being a function of the probe output and changeable). In another embodiment of the invention, it can be determined that liquid has been contacted when a count has been reached within a certain threshold several times in a row, while still having the reference count change to follow the probe output (regardless of the threshold). A digital counter can be provided to determine the frequency of the probe oscillator. A reference counter can also be provided to tune the count (frequency) from the probe oscillator counter to thereby compensate for drift.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: February 2, 1999
    Assignee: Akzo Nobel N.V.
    Inventor: Stuart R. Ball
  • Patent number: 5861228
    Abstract: An apparatus for on-line measuring physical property data of hydrocarbon products such as octane number, cetane number, density, vapour pressure and the like or gasoline/alcohol ratio, comprising means for providing (N)IR radiation in a predetermined spectral range; means for transmitting light at selected wavelengths in the (N)IR spectral region; means for delivering light from said transmitting means to a hydrocarbon product line; means for allowing an optical path length in the hydrocarbon product line; means for detecting the light transmitted through the said optical path; means for providing the obtained signal to be input to processing equipment for spectral analysis and correlating the spectral data to the physical property data of hydrocarbon products such as octane number, cetane number, density, vapour pressure and the like or gasoline/alcohol ratio.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 19, 1999
    Assignees: BP Chemicals Limited, Naphtachimie S.A.
    Inventors: Bernard Descales, Claude Granzotto, Didier Lambert, Jean-Richard Llinas, Andre Martens
  • Patent number: 5853665
    Abstract: An apparatus for automatically drawing a blood sample from a sealed container having an internal pressure below that of atmospheric pressure comprises an aspirating needle which serves to pierce the sealed container to aspirate liquid from the container, and to vent the interior of the container to the surrounding atmosphere through a suitable vent line connected to the needle. Such apparatus further comprises a vacuum pump connected to the needle through an aspiration line for aspirating blood from the sealed container. To warn the user of the possibility that fluid (e.g. cleansing diluent) in the aspirating needle has been drawn into the sealed container in the event of a vent line failure, apparatus is provided for detecting the pressure in the container immediately after the aspirating needle has pierced the container seal, and for comparing this pressure with a predetermined nominal value (typically, the negative pressure rating of the vacuum pump).
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: December 29, 1998
    Assignee: Coulter International Corp.
    Inventors: Rodrigue Ade, Robert Autrey, Santiago Galvez, Pedro E. Leon, Michael A. Krou
  • Patent number: 5846831
    Abstract: In a first embodiment of the present invention, a control method and system are provided in an exhaust emission sampling system for controlling a flow controller in order to compensate for the effects of changing water vapor content in a diluted sample having a predetermined dilution ratio. A water measuring device such as a relative humidity sensor generates a water vapor signal based on the amount of water vapor in the diluted sample. The water vapor signal is then processed within a control unit to obtain a value for the amount of water in the diluted sample. A control signal is generated by the control unit based on the amount of water vapor, flow rate of the exhaust emissions, and also, on the type of fuel used in the combustion process to control the flow controller which is, preferably, a mass flow controller.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: December 8, 1998
    Assignee: Horiba Instuments, Inc.
    Inventor: William M. Silvis
  • Patent number: 5827480
    Abstract: Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: October 27, 1998
    Assignee: The Perkin-Elmer Corporation
    Inventors: Lawrence A. Haff, Enrico Picozza, Will Bloch, Timothy M. Woudenberg
  • Patent number: 5824270
    Abstract: An ultra high sensitive on-line water monitor is disclosed. The on-line water monitor can determine the concentration of a wide range of inorganic contaminants in water at parts per trillion level in real time. The list of inorganic elements detectable by the instrument is as follows: Be, Mg, Ca, Th, V, Ti, Cr, W, Mn, Fe, Co, Ni, Cu, Au, Zn, Cd, Al, Pb, Sb, Bi, Hg, and other elements which are suitable for detection and assaying with spectrophotometric (also known as colorimetric) technique. The on-line water monitor described herein surpasses the currently available analytical instruments (such as inductively coupled mass spectrometers (ICP-MS), atomic absorption spectrometers, and atomic emission spectrometers) in a number of factors: cost, on-line operation, speed, ease of automation, low power requirements, sensitivity, and selectivity.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: October 20, 1998
    Inventor: Tenneti V. Rao
  • Patent number: 5817927
    Abstract: Methods and apparatus are provided for detection of leaks in boilers containing a temperature control liquid which is supplemented with feedwater and removed as blowdown and steam. The methods include measuring rates associated with the feedwater supplementation and blowdown and steam removal means, adding a tracer in a manner to ensure a non-constant concentration in the temperature control liquid, determining the concentration of the tracer in the blowdown, calculating the mass of the temperature control liquid, calculating the unaccounted for water rate and comparing this rate with zero to determine if a leak condition is present.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: October 6, 1998
    Assignee: BetzDearborn Inc.
    Inventors: Haiwen Chen, Ke Hong
  • Patent number: 5807525
    Abstract: An apparatus and process are disclosed for optimizing the repetitive steps in a solid-phase oligonucleotide synthesis by continuous optical scanning of the effluent stream from the reaction module and by computerized processing and implementation of the scanning data.
    Type: Grant
    Filed: February 29, 1996
    Date of Patent: September 15, 1998
    Assignee: Hybridon, Inc.
    Inventors: Stephen Allen, Hubert Koster, Edward Ashare, Donald W. Euwart, Jennifer Fernandes
  • Patent number: 5804405
    Abstract: A method is taught by which a sample can be analyzed for the selective determination of the total concentration of bilirubin (B.sub.t), the concentration of conjugated bilirubin (B.sub.c), the concentration of unconjugated bilirubin (B.sub.u), the concentration of unbound bilirubin (b), the concentration of unbound, unconjugated bilirubin (b.sub.u) using a unique combination of enzymatic and colorimetric methods in a single assay, so that the potentially neurotoxic, non-albumin bound, unconjugated fraction of total bilirubin in the sample (i.e., b.sub.u) can be measured in a simple, quick and accurate manner. A kit utilizing the same assay is also described. Both kit and methods will be of use to the clinician and general researcher. The B.sub.t, B.sup.c, B.sub.u, b and b.sub.u are determined using spectra, absorption or emission characteristics in combination with kinetic measurements of rates of reaction of chemical processes.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: September 8, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Charles E. Ahlfors
  • Patent number: 5798268
    Abstract: A device for measuring free acid concentrations in a solution bearing an ionic constituent therein, forms a test sample of the solution and measures the concentration of the ionic constituent in solution in the test sample. The device measures conductivity of the test sample and calculates the concentration of free acid in the test sample based on the conductivity and the concentration of the ionic constituent in solution.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: August 25, 1998
    Assignee: Lakefield Research Ltd.
    Inventors: Richard C. Swider, Steven A. Webster
  • Patent number: 5795996
    Abstract: A method for monitoring water quality including deriving calcium hardness and M alkalinity from the linear functional relation between calcium hardness and specific conductivity, and that between log value of M alkalinity and pH value, simplifying the temperature curve into a formula, and calculating directly the saturation index. A multipurpose and inexpensive automatic water quality monitoring apparatus that can be adapted for use in cooling towers, swimming pools, and boilers may be made from a combination of an conductivity meter, pH meter, and oxidation reduction potential meter commonly used in testing, and a simple algorithm of a central processing unit.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: August 18, 1998
    Assignee: Industrial Technology Research Institute
    Inventors: Chen-Chang Chang, Shu-Fei Chan, Dong-Yuan Lin, Jen-Chung Chen, Guo Chen Chen, Don H. C. Chen
  • Patent number: 5779977
    Abstract: Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: July 14, 1998
    Assignee: The Perkin-Elmer Corporation
    Inventors: Lawrence A. Haff, Enrico Picozza, Will Bloch, Timothy M. Woudenberg
  • Patent number: 5774875
    Abstract: A recordkeeping method comprises assigning serialized portable memory devices to individual lots of material and manufacturing process batches, writing identification and requirements data into the portable memory devices, writing manufacturing and test data into the portable memory devices during the process and writing the manufacturing and test data from one portable memory device into another by first reading the identification data from the both portable memory devices, comparing the identification data read from the two portable memory devices and writing the manufacturing and test data into the other portable memory device if the comparison is favorable.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: June 30, 1998
    Assignee: Base Ten Systems, Inc.
    Inventors: Joel E. Medeiros, Louis M. Gaburo, Stewart E. Hartkopf
  • Patent number: 5757659
    Abstract: An automatic analysis system comprising analytical equipment and a host computer connected to the analytical equipment. The host computer assigns identification numbers to pieces of analysis information, respectively, further assigns identification numbers to the pieces of analysis information respectively, to relate the pieces of analysis information to each other, groups a predetermined number of the pieces of analysis information to form pieces of group information, assigns identification numbers to the pieces of group information, respectively, further groups a predetermined number of the pieces of group information to form pieces of group information, and then assigns identification numbers to the pieces of group information, respectively. A storage device is provided for storing the pieces of analysis information and group information to which the identification numbers are given by the host computer.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: May 26, 1998
    Assignee: NGK Insulators, Ltd.
    Inventors: Toyofumi Arai, Akira Narukawa
  • Patent number: 5757660
    Abstract: A wet scrubber control system is configured with a pH sensor and a conductivity sensor in the return solution, and with a conductivity sensor in the feed solution. Concentration of the scrubbing agent within the feed solution is determined using the conductivity of the feed solution, corrected by subtracting a bias therefrom. The bias is established by first measuring the concentration of scrubbing agent in the return solution using the pH sensor. An expected conductivity of the return solution is then looked-up. The bias is set as the difference between the expected conductivity of the return solution and a measured conductivity of the return solution.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: May 26, 1998
    Assignee: The Foxboro Company
    Inventor: Wolf Musow
  • Patent number: 5753508
    Abstract: In a method of testing a function of at least one detector at an inspection station (S) for containers, particularly in an inspection unit (R) for multi-trip bottles, a test gas is fed from a source (10) to the inspection station, or as the case may be to the detector(s), at periodic intervals.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: May 19, 1998
    Assignee: Elpatronic AG
    Inventors: Peter Murday Robertson, Martin Rosatzin
  • Patent number: 5750186
    Abstract: The present invention relates to coating and printing methods for the deposition of aqueous compositions. The composition may be adapted to any method without the need to change its chemical content. Viscosity is determined and adjusted by raising and lowering the temperature. High gloss value, increased film integrity and enhanced mar resistance result.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: May 12, 1998
    Inventor: Joseph Frazzitta
  • Patent number: 5746976
    Abstract: A detachable gas analyzing apparatus has a plurality of gas analyzer units insertable into and removable from a the front side of a container case. Complementary electrical and gas connectors are disposed on the rear side of the gas analyzer units and the container case. Guides and engaging rails guide the gas analyzer units as they are inserted into the container case. The gas connectors are substantially self-aligning by the provision of complementary tapered portions formed on gas sockets and plugs. The gas connectors also align the electrical connectors and provide compensation for linear misalignment. A plurality of gas connectors may also be employed, forming a number of inward and outward gas passages.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: May 5, 1998
    Assignee: Horiba Ltd.
    Inventors: Shinsaku Yamada, Hideki Ohashi, Sumio Shimizu, Takao Imaki
  • Patent number: 5747342
    Abstract: Methods and apparatus for monitoring and controlling pH, phosphate, and sodium to phosphate ratio in boiler systems operating with captive alkalinity chemistry are described. The methods for monitoring and controlling these parameters include the steps of determining the phosphate concentration via FIA, determining the pH, and using these values to determine the sodium to phosphate ratio. These values are then compared to the optimum values for the boiler system being treated; on the basis of this comparison, adjustments to the feed rate of water treatment chemicals being added to the system are then made. The apparatus includes a device for determining phosphate concentration via FIA, a device for determining pH, a means for determining sodium to phosphate ratio and a device for adjusting the feed rate of water treatment chemicals being added to the system. The device for adjusting the chemical feed rate is computer controlled.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: May 5, 1998
    Assignee: Calgon Corporation
    Inventor: John D. Zupanovich
  • Patent number: 5746977
    Abstract: An automatic analyzer in which a suitable transmission destination remote from a body of the automatic analyzer is selected in accordance with the contents of to be transmitted and the contents are transmitted to the transmission destination; a suitable operation control instruction is received from a suitable person on duty; and a suitable process is carried out to make it possible to improve analysis efficiency.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: May 5, 1998
    Assignee: Hitachi, Ltd.
    Inventors: Kyoko Imai, Kazumichi Imai, Yasushi Nomura
  • Patent number: 5730937
    Abstract: A polymer processing system has a polymer input and an electrolyte input which may be varied independently of each other. The polymer and electrolyte are combined and mixed to provide an out flowing solution which flows through a sensor cell that gives an output signal indicating the concentration of polymer in the solution leaving the processing system. The user repeatedly and incrementally sets the inflows of polymer and electrolyte to provide a preselected variety of concentrations of polymer in the out flowing solution. On each incremental setting, a memory stores information relating the concentration to the output signal. Thereafter, the processing system automatically maintains any desired polymer concentration in joint response to the output signal and the stored information.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: March 24, 1998
    Inventor: Dennis G. Pardikes
  • Patent number: 5730866
    Abstract: An automatic ion residue monitoring and testing system that has a particular application to quantify ionic residue on a printed circuit board. The monitoring system is a stand-alone unit that includes a purification system for providing deionized water. Deionized water from purification system is heated and sent to an extraction tank where it is held in a controlled quantity. A printed circuit board is placed in the extraction tank and the heated deionized water is caused to circulate through the extraction tank so as to remove ionic contamination on the circuit board. The system then automatically extracts a controlled quantity of now ionized water from the extraction tank and sends it to an ion chromatograph. The ion chromatograph tests the contaminated water, and provides a readout of the level of ionic contamination in the water.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: March 24, 1998
    Assignee: Delco Electronics Corporation
    Inventors: David A. Cavotta, Michael C. Huggins, Kristine R. Bewley
  • Patent number: 5723337
    Abstract: A method for measuring and controlling the oxygen concentration in silicon melts which are contained in a silica glass crucible or which can be touched by a silica glass surface can especially be used for achieving a defined, uniform axial and radial oxygen concentration in a growing silicon crystal. The measurement of the oxygen concentration is realized by an electrochemical solid ionic sensor dipped into the melt; the voltage is measured between the sensor and the growing silicon crystal. The oxygen concentration in the melt is controlled by applying a voltage between crystal and silica glass crucible. The apparatus for putting the method into practice includes an electrochemical solid ionic sensor formed of a silica glass tube which encloses a metal/metal oxide mixture, contacted by a metal wire.
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: March 3, 1998
    Assignee: Georg Muller
    Inventors: Georg Muller, Rainer Marten, Albrecht Seidl
  • Patent number: 5720889
    Abstract: A method for treating waste water streams by introducing a mixture of pre-heated waste water and an amount of oxidant lower than that required to oxidize all the organic matter in the waste stream into the front port of an elongate tubular reaction chamber. The amount of oxidant is preferably high enough, however, to raise the temperature of the stream in the reaction chamber to 750.degree.-1,200.degree. F. A first injection side port is preferably located downstream from the front port of the reaction chamber at a distance at which the temperature has reached a maximum value, and 90-100% of the available oxidant has been consumed. Oxidant and water may be simultaneously injected through the first port, in a manner that the amount of oxidant is adequate to oxidize a specified amount of organic matter, and the amount of water is effective to counterbalance the heat produced by the reaction of the co-injected oxidant with the respective organic matter.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: February 24, 1998
    Assignee: RPC Waste Management Services, Inc.
    Inventors: Roy Nelson McBrayer, Jr., James Murray Eller, Jimmy Glen Swan, James Edward Deaton, Robert Ray Gloyna, Jerry Franklin Blagg
  • Patent number: 5720923
    Abstract: Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: February 24, 1998
    Assignee: The Perkin-Elmer Corporation
    Inventors: Lawrence A. Haff, Enrico Picozza, Will Bloch, Robert Ragusa, Joseph DiCesare, David Tracy, Paul Saviano, Timothy M. Woudenberg
  • Patent number: 5706455
    Abstract: A networked control system includes graphical representations of actual devices coupled to a network. The graphical representations include symbols that provide an actual picture of the devices and means for displaying values and status of the devices. A controller uses a system database to create an application database that is used for controlling and monitoring the devices. The system database and application database combine to form a real-time distributed database for controlling devices on the network. The system database includes templates for the physical devices with a control structure that has prelinked parameters that relate to the representation. A graphic editor allows a user to create the database from templates in the system database. Data and other device parameters are automatically linked to a device symbol when creating the graphical representations. A process controller couples the devices to the network and provides the data and status of the networked device to the system.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: January 6, 1998
    Assignee: Square D Company
    Inventors: Allen D. Benton, Leon J. Hochstedler, Kevin A. Hughes, Paul H. Knapke, Michael J. Monteiro, Christopher J. Protopapas, Fred Van Eijk, Frank J. Donnelly, A. Donald Hale, Jr., Keith E. Sarbaugh, Winthrop G. Worcester