Gas Chromatography Patents (Class 422/89)
  • Patent number: 10466224
    Abstract: A gas chromatography instrument comprising a first autoinjector in communication with a first column, a second autoinjector in communication with a second column, a first flame ionization detector in communication with the first column, a second flame ionization detector in communication with the second column, wherein the first column is housed in a first compartment and the second column is housed in a second compartment.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 5, 2019
    Assignee: SEPARATION SYSTEMS, INC.
    Inventors: Joaquin A. Lubkowitz, Claudio M. Ceccarelli, Roberto I. Meneghini
  • Patent number: 10338047
    Abstract: A mechanism is provided for detecting air-pollution anomalies. A historical air-pollution pattern is identified for each of a plurality of air-pollution monitoring stations. For each of the plurality of air-pollution monitoring stations, responsive to receiving real-time data from a particular air-pollution monitoring station, the real-time data is compared to the historical air-pollution pattern associated with the particular air-pollution monitoring station. A density difference value is generated based on the comparison of the real-time data to the historical air-pollution pattern associated with the particular air-pollution monitoring station and a determination is made as to whether the density difference value is greater than a predetermined confidence threshold.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: July 2, 2019
    Assignee: International Business Machines Corporation
    Inventors: Liang Liu, Junmei Qu, Wen J. Yin, Chao Q. Zhu, Wei Zhuang
  • Patent number: 10332735
    Abstract: A sample preparation apparatus for an elemental analysis system comprising a sample combustion and/or reduction and/or pyrolysis arrangement for receiving a sample of material to be analyzed, and producing therefrom a sample gas flow containing atoms, molecules and/or compounds; a gas chromatography (GC) column into which the sample gas flow is directed; a heater for heating at least a part of the GC column; and a controller for controlling the heater. The controller is configured to control the heater so as to increase the temperature of at least the part of the GC column while the sample gas flow in the GC column elutes.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: June 25, 2019
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Christopher Brodie, Oliver Kracht, Alexander Hartwig, Michael Krummen, Johannes Schwieters
  • Patent number: 10302605
    Abstract: A column assembly for gas chromatography, which is coolable by a fluid, includes a capillary column, a heating element for heating at least a portion of the capillary column, and a tube having a lumen and in contact with at least one of the capillary column and the heating element. When energized, the heating element raises the temperature of the capillary column. To lower the temperature of the capillary column, a fluid flows through the tube, and heat is transferred from the capillary column to the fluid in the tube.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: May 28, 2019
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Robert V. Mustacich
  • Patent number: 10215737
    Abstract: A method for preparing a sample for analysis includes separating a gas sample into at least one component sample in a separation unit. The output of the at least one component sample from the separation unit is detected, for example, using a thermal conductivity detector. A hydrocarbon in the component sample is combusted in a combustion unit to generate a combustion product. The at least one component sample is collected in a sample collector and supplied to an analysis unit. In some embodiments, the analysis unit may be used to determine an isotopic ratio of the at least one component sample.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: February 26, 2019
    Assignee: WEATHERFORD SWITZERLAND TRADING AND DEVELOPMENT GMBH
    Inventors: Dennis D. Coleman, John Boettcher, Gavin Atlas Steele, IV
  • Patent number: 10132163
    Abstract: Assorted apparatus and methods optimize the detection of gas entrapped in drilling fluid. A mudlogging injection system can have a processor that autonomously injects sample gas into a gas chromatograph with near atmospheric pressures to optimize sample gas testing time and accuracy. The processor can autonomously detect errors, such as gas chromatograph detector drift, and conduct chromatograph adjustments to ensure accurate detection of different constituent gases entrapped in the drilling fluid.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: November 20, 2018
    Assignee: IBALL INSTRUMENTS, LLC
    Inventor: Carl Bright
  • Patent number: 10018607
    Abstract: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: July 10, 2018
    Assignees: Temasek Polytechnic, AWAK TECHNOLOGIES PTE. LTD.
    Inventors: Christian Gert Bluchel, Yanmei Wang, Hua Zhang, Jui Pin Er, Kim Jyh Wong
  • Patent number: 9958423
    Abstract: The present invention relates to a method for simulating a chromatographic run on a chromatograph (5) with a computation device (3) comprising at least one processor (7) and an associated digital memory (9), wherein the chromatographic run uses a mobile phase (31) comprising a mixture of at least two eluent constituents having different chromatographic properties and forming an eluent profile (33). The invention also relates to a computer program for performing the method, and an apparatus comprising a computation device and a chromatograph for performing the method.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: May 1, 2018
    Assignee: BIOTAGE AB
    Inventor: Erik Hallin
  • Patent number: 9874513
    Abstract: An isotope ratio of a continuous sample is measured in an isotope ratio spectrometer. At least one sample isotope ratio is measured over a measurement time period tns, (n?1) and a sample concentration cns is measured over at least a part of the measurement time period tns. A reference gas concentration cnref for the spectrometer is selected for reference to the sample measured during the measurement time period tns, on the basis of the measured sample concentration cnref. An isotope ratio of the reference gas is measured at the selected reference gas concentration cnref in the spectrometer. The at least one isotope ratio of the sample measured during the measurement time period tns is calibrated using the measured isotope ratio of the reference gas at the corresponding reference gas concentration cnref and a plurality of calibrated isotope ratios and a plurality of sample gas concentration measurements are determined, each being for a different time.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: January 23, 2018
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Hans-Juergen Schlueter, Oliver Kracht, Jens Radke, Benno Strasser, Johannes Schwieters, Eric Wapelhorst
  • Patent number: 9791151
    Abstract: The invention relates to a controlled combustion system for the simultaneous analysis of the thermodynamic efficiency of combustion and total polluting emissions in solids with combustible potential, including: a pre-chamber, a combustion chamber, a heat transfer unit which includes a connection for a device that analyses combustion gases to determine the performance of combustion and burning, and a unit for storing the combustion emissions, which comprises a container for storing the sample and a means of collecting samples for the simultaneous collection of gases and particulate matter for analyzing the combustion emissions.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 17, 2017
    Inventors: Francisco Javier Cereceda Balic, Mario Gonzalo Toledo Torres
  • Patent number: 9696286
    Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 4, 2017
    Assignee: VUV Analytics, Inc.
    Inventors: Dale A. Harrison, Anthony T. Hayes, Phillip Walsh
  • Patent number: 9632064
    Abstract: An injection port for a gas chromatograph (GC) is operated such that, during an injection sequence, an inert gas is used for sample transfer to the analytical column while hydrogen is subsequently utilized for the majority of the analytical separation. This allows for a high degree of chromatographic efficiency, while also reducing unwanted chemical reactions involving hydrogen and/or reactive solvents in a hot injection port. Certain embodiments also provide an increased margin of safety when using hydrogen, since the total flow may be limited such that the concentration of hydrogen in the GC oven never exceeds a safety limit, such as the lower explosive limit.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: April 25, 2017
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Franco Ponciroli, Paolo Magni
  • Patent number: 9612228
    Abstract: An apparatus for detecting a presence of at least one analyte in a gas sample. The apparatus comprises a pump for drawing a gas sample from an ambient air, a passage having first and second ends, a chamber connected to the first end and containing a concentrating element for collecting at least one analyte from the gas sample, a chromatographic separator connected to a second end of the passage, and a gas source for streaming a carrier gas via the chamber to transfer the at least one analyte toward at least one chemical detector, via the chromatographic separator, in a first direction. The pump draws the gas sample via the chamber in a second direction and the first and second directions are substantially opposing to one another.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: April 4, 2017
    Assignee: S.T.I. Security Technology Integration Ltd.
    Inventors: Yuval Ovadia, Amos Linenberg
  • Patent number: 9506863
    Abstract: Processes and apparatuses are provided for the liberation of one or more volatile organic compounds from a test sample. The processes include exposing a sample to light of a wavelength less than 400 nm, subjecting the sample to heat, and collecting one or more volatile organic compounds produced from the sample. The volatile organic compounds are detected by any of various methods, and are optionally identified by methods such as FTIR. The processes and apparatus provide for improved detection of relevant volatile organic compounds that are otherwise undetectable by traditional processes.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: November 29, 2016
    Assignee: Toyota Motor Engineering & Manufacturing North America, Inc.
    Inventors: David Lee Hicks, Mark Timothy Bacchus
  • Patent number: 9285344
    Abstract: To provide a discharge ionization current detector 3, where a partition 13a in which a through hole for penetrating a tubule 24 for introducing a sample gas is created is provided between a collector electrode 20 and an outlet for discharging a gas 26 so that a gas for generating plasma that has been generated by electrodes for discharge 15, 16 and 17 passes through a gap between the through hole and the tubule 24 so as to be directed towards the outlet for discharging a gas, and thus, the air that has entered from the other side 25 of the partition cannot pass through the through hole in the opposite direction.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: March 15, 2016
    Assignee: SHIMADZU CORPORATION
    Inventors: Shinji Uchiyama, Yasunori Terai
  • Patent number: 9222920
    Abstract: In order to provide an elemental analyzer that, without providing a buffer tank, can cope with measurements of a low concentration sample to a high concentration sample on the basis of a simple configuration, the elemental analyzer is provided with: an extraction furnace 1 adapted to heat a sample contained in a crucible R, and gasify an element contained in the sample into sample gas; an introduction flow path L1 adapted to introduce carrier gas into the extraction furnace 1; a lead-out flow path L2 adapted to, from the extraction furnace, lead out mixed gas in which the sample gas and the carrier gas are mixed; an elemental analysis part 3 that is provided in the lead-out flow path L2 and analyzes elements contained in the mixed gas; a bypass flow path L3 that branches from the introduction flow path L1 and joins the lead-out flow path L2; and a valve 4 that is provided in the bypass flow path L3 and can adjust an opening level.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: December 29, 2015
    Assignee: HORIBA, LTD.
    Inventors: Akihiro Hirano, Takahiro Yamada
  • Patent number: 9214327
    Abstract: A vacuum analyzer including a vacuum reaction chamber; a gas source; a flow rate-restricting resistance tube connected to the reaction chamber; a pressure detection device disposed upstream from the flow rate-restricting resistance tube; a flow rate adjustment for adjusting the amount of gas exiting the flow rate-restricting resistance tube so that the detected value from the pressure detection device reaches a prescribed value; a split flow path that is provided with a splitter resistance tube and divides the gas at a location between the flow rate adjustment and the pressure detection device; a passage open to the atmosphere which divides the gas flowing from upstream at a location between the flow rate adjustment and the pressure detection device and releases the divided gas to the atmosphere; and a valve provided in the passage open to the atmosphere. Therein, the split flow path is connected immediately downstream from the valve.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: December 15, 2015
    Assignee: SHIMADZU CORPORATION
    Inventor: Tomohito Nakano
  • Patent number: 8999245
    Abstract: The disclosure describes a cascaded gas chromatograph including a first gas chromatograph having a first temperature control and a second gas chromatograph coupled to the first gas chromatograph. The first and second chromatographs have individual temperature controls that can be controlled independently of each other. Other embodiments are disclosed and claimed.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: April 7, 2015
    Assignee: Tricorn Tech Corporation
    Inventors: Li-Peng Wang, Chien-Lin Huang, Tsung-Kuan A. Chou
  • Patent number: 8968560
    Abstract: Methods and related apparatuses and mixtures are described for chromatographic analysis. The described system includes a pressurized source of a mobile phase and a flow path in fluid communication with the pressurized source such that the mobile phase flows through the flow path. The system also includes an injector in fluid communication with the flow path and downstream of the pressurized source, the injector being configured to inject a sample into the flow path. A first column located downstream of the injector, contains a stationary phase, and forms part of the flow path. A first detector is positioned to detect properties of fluid in the flow path at a location downstream of the injector and upstream from the first column. A second detector is positioned to detect properties of fluid in the flow path at a location downstream of the first column.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 3, 2015
    Assignee: Schlumberger Technology Corporation
    Inventor: William H. Steinecker
  • Patent number: 8951471
    Abstract: Certain embodiments described herein are directed to jet assemblies that include a substantially inert fluid flow path. In some examples, a jet assembly includes a fluid flow path comprising a substantially inert metal in a fluid flow path. Devices and systems using the jet assembly are also described. In other embodiments, a brazeless or weldless jet assembly is provided. In some embodiments, the brazeless jet assembly may include an inert material or coating, e.g., a silica coating, in a fluid flow path.
    Type: Grant
    Filed: February 26, 2011
    Date of Patent: February 10, 2015
    Assignee: Perkinelmer Health Sciences, Inc.
    Inventor: Rosario Mannino
  • Patent number: 8883508
    Abstract: In some embodiments, apparatus and systems, as well as methods, may operate to draw a formation fluid sample into a sampling port included in a down hole tool, to vaporize some part of the fluid sample to substantially fill an injection port with a gas phase, to differentiate gas components in the gas phase to provide differentiated gas components along a concentration gradient, to detect the differentiated gas components, and to determine a fingerprint of the differentiated gas components. Other apparatus, systems, and methods are disclosed.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: November 11, 2014
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Christopher M. Jones, Michael T. Pelletier
  • Patent number: 8871149
    Abstract: This invention is related to a gas chromatograph wherein more substitutable modules are foreseen, in particular injector modules and/or detector modules, as well as one embodiment in an oven module. Each module is insertable in a seat of the gas chromatograph mainframe with fast connections of its electronic and pneumatic means to corresponding outlets on said mainframe. Each module has its own heating element.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: October 28, 2014
    Assignee: Thermo Fisher Scientific S.p.A.
    Inventors: Giacinto Zilioli, Stefano Pelagatti, Paolo Magni
  • Patent number: 8808629
    Abstract: The invention relates to a transfer unit for analysis devices, containing a tube-shaped assembly which can be heated by an electric heater in a programmed manner, a tube (6) which is arranged in the sample chamber (18) and into which the end of a gas chromatographic separating column can be inserted at the end of said tube, and means for introducing carrier gas into the tube (6), said transfer unit being characterized in that a temperature sensor (8) is arranged in the ring chamber (5) between the inner wall of the assembly and the evaporator tube (6). The transfer unit can be a sample introduction device for a gas chromatograph having a sample introduction head (18), and the assembly can be a sample introduction chamber in which an evaporator tube is provided, wherein the end of a gas chromatographic separating column can be inserted into the end facing away from the sample introduction head (18).
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: August 19, 2014
    Assignee: Joint Analytical Systems GmbH
    Inventor: Joachim Gerstel
  • Patent number: 8778059
    Abstract: Methods and related systems are described for improving component separations in chromatography through novel techniques. The improvements in separation is due primarily to the provision of differential acceleration of the components being separated. Various systems and methods for providing differential acceleration are described including: increasing the cross section of the column towards the column outlet, changing the thickness or other composition of stationary phase within the column, and providing a temperature and/or mobile phase velocity gradient along the column.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 15, 2014
    Assignee: Schlumberger Technology Corporation
    Inventors: William H. Steinecker, Jagdish Shah, Oleg Zhdaneev, Gordon R. Lambertus, Hua Chen
  • Patent number: 8771597
    Abstract: The invention relates to an apparatus for the determination of a concentration of a component to be measured in a gas, comprising a light source, a wavelength selection unit, a measurement cuvette, a reference cuvette arranged in the optical beam path in parallel thereto, at least one light receiver and an evaluation unit which determines the concentration from the signals of the light receiver, wherein the gas to be analyzed is supplied to the measurement cuvette, on the one hand, and, on the other hand, to the reference cuvette via an absorption apparatus which includes a substance which completely absorbs the component to be measured. Further, the component to be measured is H2S and a wavelength selection unit is provided for the selection of an absorption wavelength.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: July 8, 2014
    Assignee: SICK AG
    Inventors: Michael Zochbauer, Carsten Rogge, Dominikus Huttner
  • Patent number: 8722417
    Abstract: An apparatus is provided for sensing an analyte in a fluid.
    Type: Grant
    Filed: January 20, 2007
    Date of Patent: May 13, 2014
    Assignee: Invoy Technologies, L.L.C.
    Inventor: Lubna Ahmad
  • Patent number: 8695401
    Abstract: The disclosure describes a substrate with a fluid-handling assembly coupled to the substrate, the fluid-handling assembly including a plurality of fluid-handling components removably coupled to the substrate and removably coupled to each other. The plurality of fluid handling components includes a gas chromatograph having a fluid inlet and a fluid outlet, and a detector array having a fluid inlet and a fluid outlet, wherein the fluid inlet of the detector array is fluidly coupled to the fluid outlet of the gas chromatograph. A control circuit is communicatively coupled to at least one of the plurality of fluid-handling components, and a readout circuit communicatively coupled to the detector array and to the control circuit. Other embodiments are disclosed and claimed.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: April 15, 2014
    Assignee: TricornTech Corporation
    Inventors: Li-Peng Wang, Chien-Lin Huang, Tsung-Kuan A. Chou
  • Patent number: 8642351
    Abstract: The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 ?l/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: February 4, 2014
    Assignee: Waters Technologies Corporation
    Inventors: Hongji Liu, Jeffrey W. Finch
  • Patent number: 8641882
    Abstract: Described is a capillary column cartridge. The cartridge can be used to perform separations according to various techniques such as capillary gas chromatography, capillary electrophoresis and capillary liquid chromatography. The cartridge includes a capillary column secured in a cartridge body. The capillary column includes an inlet port and an outlet port that, in some embodiments, are disposed on a planar surface of the body. When the body is engaged to a separation system module, the inlet port is aligned to receive a sample to be separated and the outlet port is aligned to provide the separated sample to the separation system module. The path of the capillary through the body has a non-planar path shape such as a coil shape. Consequently, longer column lengths can be accommodated, leading to an improvement in separation resolution. The body can include a material having a high thermal conductivity to achieve improved thermal performance.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: February 4, 2014
    Assignee: Waters Technologies Corporation
    Inventors: Joseph A. Jarrell, Keith Edward Fadgen
  • Publication number: 20140030818
    Abstract: In a method for performing a solid-phase micro-extraction, a holding device connected to an extraction device and secured on an adapter is held, while an actuating device connected to a guide device is moved. A device for performing a solid-phase microextraction comprises an actuating device connected to a guide device, and a holding device connected to an extraction device, wherein the extraction device is guided at least partially in the guide device, and wherein the extraction device is movable relative to the guide device by means of an actuation of the actuating device.
    Type: Application
    Filed: July 29, 2013
    Publication date: January 30, 2014
    Applicant: CTC Analytics AG
    Inventors: Kai Heinrich SCHUELER, Melchior ZUMBACH
  • Patent number: 8636957
    Abstract: The present disclosure relates to a spirally wrapped chromatographic structure, a system incorporating such structure and a method of providing such structure. The structure may include an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in the first surface. The structure may also include a support layer having a first surface and a second surface, the first surface of the support layer disposed on the second surface of the absorber layer, wherein the absorber layer and the support layer comprise a spiral configuration such that at least a portion of the first surface of the absorber layer contacts at least a portion of the second surface of the support layer.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: January 28, 2014
    Assignee: Southwest Research Institute
    Inventors: Stephen Thomas Wellinghoff, Kent Edward Coulter
  • Publication number: 20140024129
    Abstract: A system for determining the content of sulfur in a first fluid mixture includes a gas chromatograph including a sample valve, a first column coupled to the sample valve, and a second column coupled to the sample valve. In addition, the system includes a pyrolizer configured to subject the first fluid mixture to pyrolysis to produce a second fluid mixture that includes hydrogen sulfide. The first column is configured to separate at least a first constituent of the second fluid mixture from the hydrogen sulfide in the second fluid mixture and output a third fluid mixture including the hydrogen sulfide. The second column is configured to separate at least a second constituent in the third fluid mixture from the hydrogen sulfide in the third fluid mixture and output a fourth fluid mixture including the hydrogen sulfide. Further, the system includes a detector in fluid communication with the second column.
    Type: Application
    Filed: July 20, 2012
    Publication date: January 23, 2014
    Applicant: CAMERON INTERNATIONAL CORPORATION
    Inventors: Shirley Ann Meyer, Randy James Meyer, Stevie Horton Smith
  • Publication number: 20140017130
    Abstract: A sensor for high explosives, comprising a thin layer of fluorescent polymer covalently linked to a silica support with an oxide surface. The support preferably is a silica support, and in a preferred embodiment is a silica chromatographic support. In preferred embodiments, the fluorescent polymer is one or a few monolayers. A preferred embodiment sensor for high explosives is fluorescent polymer within or upon a porous nanostructure. In preferred embodiments the nanostructure is a porous silica nanoparticle. Embodiments of the invention provide methods, sensors, sensor kits, and sensor fabrication processes that enable detecting traces of high explosives by fluorescence quenching in combination with a chromatographic separation. A method for forming a sensor for high explosives includes preparing a fluorescent polymer, capping the reactive polymer with a reactive capping group that covalently reacts with hydroxide groups, and reacting the reactive capping group with surface hydroxides of an oxide support.
    Type: Application
    Filed: March 21, 2012
    Publication date: January 16, 2014
    Applicant: The Regents of the University of California
    Inventors: William C. Trogler, H. Paul Martinez
  • Patent number: 8623279
    Abstract: Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. A method was developed which provides phosphonium-based, pyridinium-based, and imidazolium-based IL-mediated advanced sol-gel organic-inorganic hybrid materials for capillary microextraction. Scanning electron microscopy results demonstrate that ILs can serve as porogenic agents in sol-gel reactions. IL-mediated sol-gel coatings prepared with silanol-terminated polymers provided up to 28 times higher extractions compared to analogous sol-gel coatings prepared without any IL in the sol solution.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: January 7, 2014
    Assignee: University of South Florida
    Inventors: Abdul Malik, Anne M. Shearrow
  • Publication number: 20130316388
    Abstract: This invention relates to an apparatus and a process for rapid, high-throughput analysis of fatty acids in a plurality of samples. The apparatus comprises at least one multi-vessel plate, wherein each vessel is a unit for holding a sample, or mixing and/or reacting a sample with one or more solvents or reagents; at least one matching multi-cap mat capable of sealing the vessels of the multi-vessel plate during the holding, mixing and/or reacting the sample; at least one multi-vessel plate holder having sealing units, whereby the multi-vessel plate holder, when the sealing units are engaged, presses the matching multi-cap mat onto the tops of the vessels in the multi-vessel plate sealing the vessels, so as to withstand high pressure and high temperature conditions. The process employs the apparatus that enables automated, high-throughput analysis of twenty-four fatty acid from a plurality of samples by gas chromatography flame ionization detection.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 28, 2013
    Applicant: HEALTH DIAGNOSTIC LABORATORY, INC.
    Inventors: James BOROWSKI, Alexandra SHERMAN, Jennifer WARD, Joseph P. McCONNELL
  • Patent number: 8592222
    Abstract: A method for analyzing molecular pollutants of a fluid. From a calibrated flow of fluid, a combination of a measurement of a total amount of molecular pollutants and a determination of chemical compositions and relative amounts of the molecular pollutants by adsorption on materials is carried out. The determination of the chemical compositions and relative amounts advantageously occur after a threshold value for the total measured amount is exceeded.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: November 26, 2013
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventor: Isabelle Tovena-Pecault
  • Patent number: 8592220
    Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 26, 2013
    Assignee: Intermolecular, Inc.
    Inventors: H. Sam Bergh, Jason Wells, Victor Wong, John Gallipeo, Lynn Van Erden, Anthony F. Volpe, Jeffrey Maag
  • Patent number: 8591814
    Abstract: Equipment for analyzing a fluid selected from a hydrocarbon fluid, a refinery feedstock, a refinery intermediate, a product of a refinery process, or a component or reaction product thereof, having a portable apparatus containing at least two different analytical devices, each device being able to analyze the fluid. A sample plate is provided in association with the portable apparatus which has a receiver for a fluid to be analyzed, at least two fluidic channels, at least one sensor capable of responding to a physical or chemical property of the fluid, and/or at least one sample cell, and at least one additional fluidic channel for transferring a portion of the fluid or a component or reaction product thereof from the receiver to the at least one sensor and/or sample cell.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: November 26, 2013
    Assignee: BP Oil International Limited
    Inventor: Michael Graham Hodges
  • Patent number: 8569070
    Abstract: A fitting assembly having a nut, a ferrule, and a ferrule tip that may be assembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive the first end of a ferrule, and a ferrule tip with a first end having an externally tapered portion adapted to abut the second end of the ferrule and a second end adapted to be received in a component or fitting of a liquid chromatography system. The nut, ferrule and ferrule tip of the fitting assembly have passageways therethrough for receiving and removably holding tubing.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: October 29, 2013
    Assignee: IDEX Health & Science LLC
    Inventors: Scott J. Ellis, Eric Beemer, Nathaniel Nienhuis, Craig W. Graham, Troy N. Sanders
  • Publication number: 20130259750
    Abstract: A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 3, 2013
    Inventors: Yan LIU, Kannan SRINIVASAN, Christopher A. POHL, Sheetal BHARDWAJ, Zhongqing LU
  • Patent number: 8492152
    Abstract: Apparatus and systems, as well as methods, may operate to draw a formation fluid sample into a sampling port included in a down hole tool or tool body, to vaporize some part of the fluid sample to substantially fill an injection port with a gas phase, to differentiate gas components in the gas phase to provide differentiated gas components along a concentration gradient in a receiving section, to detect the differentiated gas components with a detector, and to determine a fingerprint of the differentiated gas components. A reaction section and a vacuum section may be used for waste consumption and/or absorption.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: July 23, 2013
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Christopher M. Jones, Michael T. Pelletier
  • Patent number: 8470248
    Abstract: A detector detects the color of a medium after a gas to be identified and a reagent have chemically reacted with each other on the medium. A controller identifies color information, which is most similar to the color detected by the detector, from color information stored in a spectral database, and reads gas identifying information related to the identified color information, as gas identifying information representing the gas to be identified, from the spectral database.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: June 25, 2013
    Assignee: NEC Corporation
    Inventor: Naoki Oda
  • Patent number: 8414832
    Abstract: The invention is a chromatography apparatus which comprises at least one capillary column, which has a coil assembly of column material and a small diameter wire coated with an electrically insulating high temperature material encased within a high temperature sheath. The small diameter wire is at least one electrically conductive element co-linear with the column material. Also provided is means for directly resistively heating the at least one capillary column, and means for controlling the temperature of the capillary column. Additionally, the apparatus includes an oxygen gas containing inlet, a hydrogen inlet, an analyte port and a flame region, oxygen delivery means for delivering oxygen through the oxygen inlet to the flame region, a hydrogen and analyte delivery system for delivering hydrogen and analyte to the flame region, and a detector arranged to detect flame emission.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: April 9, 2013
    Inventors: Ned Roques, John Crandall
  • Patent number: 8408044
    Abstract: Automated systems and methods for processing liquid test samples are generally provided. Automated systems generally include a gas and liquid separator configured for removing at least one volatile component from the test sample, a first trapping vessel in fluid communication with the gas and liquid separator, wherein the first trapping vessel contains a trapping material capable of adsorbing at least one of the at least one volatile component to provide at least one adsorbed component, and a heat source configured to heat the trapping material to a temperature sufficient to release at least one of the at least one adsorbed component from the trapping material to provide at least one released component.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: April 2, 2013
    Assignee: Brooks Rand Inc
    Inventor: Paul Danilchik
  • Patent number: 8409510
    Abstract: In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: April 2, 2013
    Assignees: The United States of America as represented by the Secretary of the Navy, University of Louisville Research Foundation, Inc.
    Inventors: Robert Andrew McGill, Michael Martin, Mark Crain, Kevin Walsh, Eric Houser, Stanley Vincent Stepnowski, Viet Nguyen
  • Patent number: 8404185
    Abstract: A system for pre-concentrating analytes in a sample prior to introduction into a chromatographic column is generally disclosed comprising a housing, an adsorbent disposed in the housing, and first and second conduits having an inlet and an outlet, respectively, for transferring fluid out of and into the housing during adsorption/dry purge and desorption stages, respectively. In some embodiments, the inlet of the first conduit and the outlet of the second conduit are both disposed in one end of the housing and are offset from each other with respect to the adsorbent.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: March 26, 2013
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Andrew Tipler, Richard G Edwards, James E. Botelho
  • Publication number: 20130058830
    Abstract: The present application provides a method for determining one or two parameters of a sensor system for detecting a gaseous sample. The sensor system comprises a light source to generate a light beam, a hollow waveguide to receive the light beam and the gaseous sample, and a detector to detect an absorption peak of the gaseous sample, where the length and inner diameter of the hollow waveguide satisfy relationships as disclosed herein.
    Type: Application
    Filed: November 5, 2012
    Publication date: March 7, 2013
    Applicant: GEOISOCHEM CORPORATION
    Inventor: GEOISOCHEM CORPORATION
  • Patent number: 8389289
    Abstract: A gas chromatograph (GC) apparatus capable of detecting abnormality, in which a reference retention index is obtained from a result obtained by analyzing a given substance and a retention-index reference substance under adequate analysis conditions using a normal column, and stored in a storage section. Further, under a condition that the apparatus can perform normal analysis, the given substance is subjected to GC analysis to obtain a reference retention time, and the obtained reference retention time is stored in the storage section. A diagnosis processing section is operable to compare each of an actual retention time and an actual retention index with a respective one of the reference retention time and the reference retention index. If a deviation therebetween or abnormality is detected, the diagnosis processing section is operable to estimate a causal factor of the abnormality.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: March 5, 2013
    Assignee: Shimadzu Corporation
    Inventor: Shuichi Kawana
  • Publication number: 20120329166
    Abstract: A flow regulating system for maintaining a stable air flow comprising at least one pump, a mass flow sensor, an ambient temperature sensor, an ambient pressure sensor, a temperature compensation sensor measuring the temperature of said mass flow sensor, and a control system is disclosed, as well as a method for measuring a flow using said flow regulating system, a device for the monitoring of air-borne compounds present in air in both a gas phase and a particle phase, wherein it comprises a sampling device, an enrichment trap 1, a calibration and tuning module, a blank module, said flow regulating system, a chromatography unit, and a detection unit, and a method for the detection of air-born compounds in an air flow by using said monitoring device.
    Type: Application
    Filed: March 1, 2011
    Publication date: December 27, 2012
    Inventors: Gunnar Skarping, Marianne Dalene
  • Patent number: 8323488
    Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: December 4, 2012
    Assignees: California Institute of Technology, City of Hope
    Inventors: Yu-Chong Tai, Qing He, Jun Xie, Changlin Pang, Terry D. Lee, Damien Rodger, Matthieu Liger