Abstract: The present invention provides a method for preparing battery-grade anhydrous iron phosphate from liquid crude monoammonium phosphate, and belongs to the technical field of chemical industry production. In the present invention, ferrous sulfate solution and liquid crude monoammonium phosphate are used as raw materials, and ferrous iron is oxidized to ferric iron and separates out iron phosphate precipitate under the action of an oxidizing agent to obtain iron phosphate intermediate slurry; and then battery-grade anhydrous iron phosphate is finally obtained through solid-liquid separation, washing, aging, solid-liquid separation, washing, drying, dehydration and breaking up. The method provided by the present invention realizes the resource utilization of liquid crude monoammonium phosphate, has simple process and convenient operation and produces less waste water.

Abstract: The coatings of the invention provide potassium in a readily available form in combination with other nutrients that promote early plant growth and health. The potassium-based fertilizer product which comprises: potassium, zinc, manganese and iron. Calcium may also be added. The mixture is applied in a 325 MESH or finer powder to suitable agronomic carriers.

Abstract: The present invention relates to methods for preparing amorphous aluminum hydroxyphosphate. An aluminum salt and a phosphate solution are co-mixed at a constant ratio in the presence of a buffer. Preferably, an excess of the phosphate solution is used to act as a buffer. Due to the presence of a buffer, the pH is maintained constant during reaction (after initial rapid equilibration) without active adjustment. The methods are particularly applicable for the large scale manufacturing of aluminum phosphate adjuvant. Aluminum phosphate is used as an adjuvant in vaccine formulations, particularly those including a protein or saccharide antigen.

Abstract: The present disclosure is related to articles (e.g., containers, battery packs, etc.) including a lithium material (e.g., one or more lithium-containing batteries) housed therein. The articles include sulfur hexafluoride located within an interior compartment of the article to provide an inert atmosphere within the interior compartment. The present disclosure is also related to methods of inerting such articles (e.g., containers, battery packs, etc.) with sulfur hexafluoride. Additionally, the present disclosure is related to conveyed (e.g., pumped, blown, etc.) looped cooling apparatuses and systems.

Abstract: AlP composite materials comprise an AlP aggregate core, and a shell disposed partially or entirely over the core and formed from a pigment material, e.g., TiO2, having an index of refraction greater than the core, providing an overall index or refraction greater than the core and suited for use as a pigment replacement or extender. The AlP core comprises amorphous AlP, crystalline AlP, or a combination thereof, and can have an average particle size of less than about 30 microns. The TiO2 can have an average grain size less than about 10 microns. The shell can have a layer thickness that is at least about 0.0001 microns. The shell is bonded to the core by a reaction between functional groups of the shell and core. The AlP composite material can be engineered to provide properties in addition to brightness for use as a pigment such as anticorrosion and/or antimicrobial protection.

Abstract: High-purity crystalline ferric phosphate material with desirable characteristics for use in synthesis of nano-sized LFP cathode material are described. The ferric phosphate dihydrate material has as disclosed herein has a molar ratio of phosphorous to iron is from about 1.001 to about 1.05, a surface area of from about 25 m2/g to about 65 m2/g, and is substantially free of metallic or magnetic impurities. Methods of synthesizing high-purity crystalline ferric phosphate material with desirable characteristics for use in synthesis of nano-sized LFP cathode material are also described. In some embodiments, one or more magnetic traps are used during the reaction process and/or after the formation of the final product to remove magnetic impurities. In some embodiments, a synthetic method of ferric phosphate using multiple steps is described, wherein the intermediate of the synthesis is isolated and purified to improve the purity of the ferric phosphate material.

Abstract: The present invention relates to a process for the preparation of compounds of general formula (I) Lia-bMb1Fe1-cMc2Pd-eMe3Ox, wherein Fe has the oxidation state +2 and M1, M2, M3, a, b, c, d, e and x are: M1: Na, K, Rb and/or Cs, M2: Mn, Mg, Al, Ca, Ti, Co, Ni, Cr, V, M3: Si, S, F a: 0.8-1.9, b: 0-0.3, c: 0-0.9, d: 0.8-1.9, e: 0-0.5, x: 1.0-8, depending on the amount and oxidation state of Li, M1, M2, P, M3, wherein compounds of general formula (I) are neutrally charged, comprising the following steps (A) providing a mixture comprising at least one lithium-comprising compound, at least one iron-comprising compound, in which iron has the oxidation state 0, and at least one M1-comprising compound, if present, and/or at least one M2-comprising compound, if present, and/or least one M3-comprising compound, if present, and at least one compound comprising at least one phosphorous atom in oxidation state +5, and (B) heating the mixture obtained in step (A) at a temperature of 100 to 500° C.

Abstract: Metal silicates or phosphates are deposited on a heated substrate by the reaction of vapors of alkoxysilanols or alkylphosphates along with reactive metal amides, alkyls or alkoxides. For example, vapors of tris(tert-butoxy)silanol react with vapors of tetrakis(ethylmethylamido)hafnium to deposit hafnium silicate on surfaces heated to 300° C. The product film has a very uniform stoichiometry throughout the reactor. Similarly, vapors of diisopropylphosphate react with vapors of lithium bis(ethyldimethylsilyl)amide to deposit lithium phosphate films on substrates heated to 250° C. Supplying the vapors in alternating pulses produces these same compositions with a very uniform distribution of thickness and excellent step coverage.

Abstract: A method of producing an ethylenically unsaturated, typically, an ?, ? ethylenically unsaturated carboxylic acid or ester is described. The method comprises the steps of contacting formaldehyde, or a source of formaldehyde, with a carboxylic acid or ester in the presence of a catalyst and optionally in the presence of an alcohol. The catalyst comprises barium phosphate leaf or plate shaped/like crystals, or a source thereof. A catalyst system is also described. The catalyst system comprises a crystalline barium phosphate catalyst and optionally a catalyst support.

Abstract: The invention relates to a synthetic bone material and a process for making the same. The synthetic bone material may comprise multiple phases of calcium phosphate. Another aspect of the invention is a porous filter, and the method of making the same, and wherein the porous filter is substantially similar to the process for forming the synthetic bone material.

Abstract: The present invention provides white pigments of crystalline aluminum orthophosphate dihydrate, their use as white pigment in paints and also processes for their production.

Abstract: A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.

Abstract: The present invention relates to methods for preparing amorphous aluminum hydroxyphosphate. An aluminum salt and a phosphate solution are co-mixed at a constant ratio in the presence of a buffer. Preferably, an excess of the phosphate solution is used to act as a buffer. Due to the presence of a buffer, the pH is maintained constant during reaction (after initial rapid equilibration) without active adjustment. The methods are particularly applicable for the large scale manufacturing of aluminum phosphate adjuvant. Aluminum phosphate is used as an adjuvant in vaccine formulations, particularly those including a protein or saccharide antigen.

Abstract: There is provide a solid cement reactant comprising a dehydrated magnesium phosphate, and/or an amorphous or partially amorphous magnesium phosphate, and/or Farringtonite.

Abstract: A process for the synthesis of a bioceramic composition comprising calcium phosphosilicate (CPS, Ca10(PO4)4(SiO4)2), the process comprising: providing calcium or a calcium-containing compound, a phosphorus-containing compound and a silicon-containing compound; and forming a precipitate by reacting the compounds in an aqueous phase at an alkali pH.

Abstract: Proliferation of cancer cells is effectively inhibited. Provided is a cancer cell-inhibiting ceramic containing a ?-tricalcium phosphate porous granule with a particle size of 1 to 10 ?m. The ?-tricalcium phosphate porous granule is taken up into cancer cells at an affected area and have an effect of inhibiting proliferation of a cancer tissue. The ?-tricalcium phosphate porous granule with a particle size of 1 to 10 ?m can be used to more effectively inhibit the proliferation of the cancer cells.

Abstract: The present invention relates to a method for recycling LiFePO4, which is an olivine-based cathode material for a lithium secondary battery. The present invention is characterized in that a cathode material including LiFePO4 is synthesized using, as precursors, amorphous FePO4.XH2O and crystalline FePO4.2H2O (metastrengite) obtained by chemically treating LiFePO4 as an olivine-based cathode material for a lithium secondary battery, which is produced from a waste battery. Since a cathode fabricated from the LiFePO4 cathode material synthesized according to the present invention does not deteriorate the capacity, output characteristics, cycle efficiency and performance of the secondary battery and the cathode material of the lithium secondary battery may be recycled, the secondary battery is economically efficient.

Abstract: Disclosed is an exhaust gas purification catalyst carrier which includes a phosphate salt represented by formula: MPO4 (wherein M represents Y, La, or Al) or a zirconium phosphate represented by formula ZrP2O7; an exhaust gas purification catalyst containing a noble metal at least containing Rh and supported on the carrier; and an exhaust gas purification catalyst product having a catalyst support made of a ceramic or metallic material, and a layer of the exhaust gas purification catalyst, the layer being supported on the catalyst support.

Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.

Abstract: An element having an immersible portion for contact with an aqueous liquid, the immersible portion having a contact surface for contact with the aqueous liquid, the contact surface configured to have strong acidity, a radiation (e.g., ultraviolet radiation) source assembly, a radiation (e.g., ultraviolet radiation) source module and a fluid (e.g., water) treatment system incorporating this element applicable to any surface in contact with fluid that is susceptible to build-up of fouling materials. The embodiments obviates or mitigates the rate of accumulation of fouling on surfaces in contact with aqueous solution, such as the protective (e.g., quartz) sleeves in an ultraviolet radiation fluid treatment system, by modifying at least a portion of the surface of those sleeves in contact with fluid (e.g., water) to have an inherent strong surface acidity.

Abstract: Described is a method for the production of metal salts, wherein the cationic metal is preferably selected from Group I to IV metals and mixtures thereof and the anionic group is selected from phosphates, silicates, sulfates, carbonates, hydroxides, fluorides and mixtures thereof, and wherein said method comprises forming a mixture of at least one metal source that is a metal carboxylate with a mean carbon value per carboxylate group of at least 3 and at least one anion source into droplets and oxiding said droplets in a high temperature environment, preferably a flame. This method is especially suited for the production of calcium phosphate biomaterials such as hydroxyapatite (HAp,Ca10(PO4)6(OH)2) and tricalcium phosphate (TCP,Ca3(PO4)2) that exhibit excellent biocompatibility and osteoconductivity and therefore are widely used for reparation of bony or periodontal defects, coating of metallic implants and bone space fillers.

Abstract: The purpose of the present invention is to provide calcium phosphate porous material with small amount of the remaining polycyclic aromatic hydrocarbons that are toxic substances. The present invention relates to a method for the production of calcium phosphate porous material of ?-tricalcium phosphate comprising calcining micronized ?-tricalcium phosphate wherein a temperature in a furnace is retained at a temperature in a range of 250-550° C. for a certain period of time, or wherein a temperature-rising rate in the furnace while in said range is decreased to one thirds or less of that during ranges before or after said range in said calcining step.

Abstract: A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.

Abstract: A method for producing phosphates and/or compounds containing phosphates is provided, in particular alkaline-earth phosphates, alkaline-earth silicophosphates, and alkaline-earth oxides, comprising the following steps: (a) heating bones and/or fish bones or a composition of said components in a pyrolysis process in the absence of oxygen and under reductive conditions at temperatures between 500 and 1100° C., wherein among other things high-energy gases, vapors, and carbon are produced, (b) subsequently combusting the carbon produced in step (a) under oxidative conditions in an oxidation step, wherein an inorganic radical of alkaline-earth carbonates, alkaline-earth oxides, and alkaline-earth phosphates is produced.

Abstract: The present invention relates to a Process for the preparation of compounds of general formula (I), Lia-bM1bFe1-cM2cPd-eM3eOx, wherein M1, M2, M3, a, b, c, d and e: M1: Na, K, Rb and/or Cs, M2: Mn, Mg, Ca, Ti, Co, Ni, Cr, V, M3: Si, S, a: 0.8-1.9, b: 0-0.3, c: 0-0.9, d: 0.8-1.9, e: 0-0.5, x: 1.

Abstract: Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.

Abstract: Iron(III) orthophosphate of the general formula FePO4×nH2O (n?2.5), prepared by a process in which iron(II)-, iron(III)- or mixed iron(II, III) compounds selected from among hydroxides, oxides, oxidehydroxides, oxide hydrates, carbonates and hydroxidecarbonates are reacted with phosphoric acid having a concentration in the range from 5% to 50%, any iron(II) present after the reaction is converted into iron(III) by addition of an oxidant and solid iron(III) orthophosphate is separated off from the reaction mixture.

Abstract: An ultrathin film of calcium phosphate crystals having a thickness of 200 nm or less on a surface of a solid substrate, and a method for preparing the same are disclosed. Further, an amorphous dendritic extension used as an intermediate material in preparation of the ultrathin film of calcium phosphate and a method for forming the same are disclosed. The ultrathin film of calcium phosphate crystals can be coated on the surface of the solid substrate while substantially maintaining surface roughness of the solid substrate. The method employs calcium phosphate ion solutions at low temperature.

Abstract: Methods for the synthesis of tricalcium phosphates are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the tricalcium phosphate precursor precipitate. Particulate tricalcium phosphate compositions having an average crystal size of about 250 nm or less are provided. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.

Abstract: The present invention relates to a process for the preparation of compounds of general Formula (I) La-bM1bFe1-cM2cPd-eM3eOx (I), wherein Fe has the oxidation state +2 and M1, M2, M3, a, b, c, d, e and x are: M1: Na, K, Rb and/or Cs, M2: Mn, Mg, Al, Ca, Ti, Co, Ni, Cr, V, M3: Si, S, F a: 0.8-1.9, b: 0-0.3, c: 0-0.9, 15 d: 0.8-1.9, e: 0-0.5, x: 1.

Abstract: A process for the production of iron (III) orthophosphate of the general formula FePO4×nH2O (n?2.5) comprising: a) producing an aqueous solution containing Fe2+ ions by introducing, iron (II), iron (III) or mixed iron (II, III) compounds selected from hydroxides, oxides, oxide hydroxides, oxide hydrates, carbonates and hydroxide carbonates, together with elementary iron, into a phosphoric acid-bearing aqueous medium, to dissolve Fe2+ ions and to react Fe3+ with elementary Fe in a comproportionation reaction to give Fe2+; b) separating solids from the phosphoric-acid aqueous Fe2+ solution, and c) adding an oxidation agent to the phosphoric-acid aqueous Fe2+ solution to oxidize iron (II) in the solution to precipitate iron (III) orthophosphate of the general formula FePO4×nH2O. The invention includes the product of the process and its use to make LiFePO4 for batteries.

Abstract: APs are made by binary condensation via base-to-acid or acid-to-base routes. In the base-to-acid route, an aluminum hydroxide slurry is added to phosphoric acid that reacts to produce an aluminum phosphate condensate. In the acid-to-base route, phosphoric acid is added to an aluminum hydroxide slurry that reacts to produce an aluminum phosphate condensate. In an alternative base-to-acid route, an acidic aluminum phosphate is first made by adding phosphoric acid to a first amount of aluminum hydroxide slurry, and such acidic aluminum phosphate is added to a remaining amount of aluminum hydroxide slurry to react and produce an aluminum phosphate condensate. The reactions can be controlled to form an in-situ layered aluminum phosphate. So-formed APs can be amorphous, crystalline, or a combination thereof, and have low oil absorption and surface area, making them particularly useful in such end-use applications as extender pigments in coating compositions, replacing up to 70 wt % of TiO2.

Abstract: An air cathode for a metal-air battery is disclosed which contains a catalyst chosen to make the metal air battery more easily rechargeable. This catalyst is based on cobalt phosphate, cobalt borate mixed metal cobalt phosphates, mixed metal cobalt borates, or mixed metal cobalt phosphate borates.

Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.

Abstract: The present invention provides a method of crystallizing Yb:C-FAP [Yb3+:Ca5(PO4)3F], by dissolving the Yb:C-FAP in an acidic solution, following by neutralizing the solution. The present invention also provides a method of forming crystalline Yb:C-FAP by dissolving the component ingredients in an acidic solution, followed by forming a supersaturated solution.

Abstract: Salts of mineral nutrients stabilized with amino acids and/or ammonium salt, product and food supplement in which they are included and procedures of obtention, where the salts are obtained with anions of organic acids or inorganic anions and metallic cations associated with amino acids and/or ammonium salt, in which the invention introduces its general structure: {[Ac]n?·Men+?n[Amino acid and/or ammonium salt]}·xH2O Where ? represents a covalent dative bond, These new compounds have better taste and more solubility in water, making them more bioavailable.

Abstract: The present invention relates to the synthesis of bioceramics, in particular, of amorphous or cryptocrystalline calcium phosphates.

Abstract: A mixed aqueous solution is prepared in which a phosphorus source, a divalent Fe compound, and an oxidant are mixed at a predetermined ratio. Then, this mixed aqueous solution is dropwise added into a buffer solution having a pH value of 1.5 to 9, thereby to produce a precipitated powder of FePO4. This FePO4 is synthesized with a lithium compound to obtain LiFePO4. An electrode active substance containing this LiFePO4 as a major component is used as a positive electrode material of a secondary battery.

Abstract: Bone graft compositions for repairing bone defects, which are characterized by a chemical composition of cementitious, non-cementitious, highly-resorbable and poorly-resorbable particulate substances, and further characterized by a specific particle size distribution that includes two or more different ranges of particle size, are disclosed. Further disclosed are articles of manufacturing and unit dosage forms containing the bone graft compositions, methods of repairing bone defects utilizing the bone graft compositions, and processes of preparing the same. Also provided are applicators for applying flowable mixtures formed by mixing a dry composition and a liquid carrier, which are particularly useful for preparing and applying bone graft compositions, as well as methods of using same.

Abstract: A material C-AxM(XO4)y that is of particles of a compound of the formula AxM(XO4)y, wherein said particles include a carbon deposit deposited by means of pyrolysis on at least a portion of the surface thereof, and where: A is Li alone or partially replaced by at most 10 atomic % of Na or K; M is Fe(II), or Mn(II), or mixtures thereof alone or partially replaced by at most 30 atomic % of one or more metals selected from Mn, Ni and Co and/or at most 5% of Fe(III); XO4 is PO4 alone or partially replaced by at most 10 molar % of at least one group selected from SO4, SiO4 and MoO4; and where said material has a calcium impurity content of lower than about 1000 ppm.

Abstract: Disclosed here are methods for the preparation of optionally activated nanocrystalline rare earth phosphates. The optionally activated nanocrystalline rare earth phosphates may be used as one or more of quantum-splitting phosphor, visible-light emitting phosphor, vacuum-UV absorbing phosphor, and UV-emitting phosphor. Also disclosed herein are discharge lamps comprising the optionally activated nanocrystalline rare earth phosphates provided by these methods.

Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.

Abstract: This invention relates generally to electrode materials, electrochemical cells employing such materials, and methods of synthesizing such materials. The electrode materials have a crystal structure with a high ratio of Li to metal M, which is found to improve capacity by enabling the transfer of a greater amount of lithium per metal, and which is also found to improve stability by retaining a sufficient amount of lithium after charging. Furthermore, synthesis techniques are presented which result in improved charge and discharge capacities and reduced particle sizes of the electrode materials.

Abstract: Ferrous phosphate (II) (Fe3(PO4)2) powders, lithium iron phosphate (LiFePO4) powders for a Li-ion battery and methods for manufacturing the same are provided. The ferrous phosphate (II) powders are represented by the following formula (I): Fe(3-x)Mx(PO4)2.yH2O??(I) wherein, M, x, and y are defined in the specification, the ferrous phosphate (II) powders are composed of plural flake powders, and the length of each of the flake powders is 0.5-10 ?m.

Abstract: A process for the treatment of gas phase alkaline chlorides in a combustion plant that is arranged for combustion of solid fuel and which includes a combustion chamber from which a flue-gas flow is directed to pass a heat transfer device. A phosphorous substance is added to the flue-gas flow, separate from the fuel, the substance chosen from a group of substances that form phosphorous oxide at combustion temperatures of approx. 500° C. or above, wherein the phosphorous substance is distributed in the flue-gas at a location upstream of the heat transfer device. The phosphorous substance is added to an amount which results in phosphatising of gas phase alkaline chlorides included in the flue-gas flow before the chlorides reach the heat transfer device. A corresponding combustion plant is disclosed, as well as the use of a phosphorous substance for phosphatising alkaline chloride in gaseous phase in a flue-gas flow.

Abstract: A method for producing phosphates and/or compounds containing phosphates is provided, in particular alkaline-earth phosphates, alkaline-earth silicophosphates, and alkaline-earth oxides, comprising the following steps: (a) heating bones and/or fish bones or a composition of said components in a pyrolysis process in the absence of oxygen and under reductive conditions at temperatures between 500 and 1100° C., wherein among other things high-energy gases, vapors, and carbon are produced, (b) subsequently combusting the carbon produced in step (a) under oxidative conditions in an oxidation step, wherein an inorganic radical of alkaline-earth carbonates, alkaline-earth oxides, and alkaline-earth phosphates is produced.

Abstract: This study reports in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). Experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it biocompatible and bioinert CPC. These bioinert CPCs are candidates for use in useful applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

Abstract: A method for sintering lithium contained electrode material includes: depositing a mixture of a particle like lithium compound and a substance M in a metal container, where M is a chemical element selected from a group consisting of iron (Fe), phosphor (P), cobalt (Co), nickel (Ni), manganese (Mn), vanadium (V), and carbon (C), or an oxide or compound thereof; subjecting the mixture deposited in the metal container to heat treatment by heating the metal container in two phases of which temperature ranges for heating are respectively 300-700° C. and 500-900° C.; and grinding the heat-treated mixture to obtain a powder like lithium contained electrode material. According to the method of the present invention, in the process of sintering and synthesis, it is not necessary to supply an external (or a great amount of) protective gas, so that substantial reduction of processing cost and time is realized.

Abstract: A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.

Abstract: The present invention provides novel calcium phosphate nanoparticles suitable for efficient encapsulation of biologically active molecules. The invention further provides pharmaceutical compositions comprising these nanoparticles, as well as methods of making such nanoparticles and using them as carriers for therapeutic delivery of biologically active macromolecules.