Abstract: The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow.

Abstract: The present invention has an object to provide a highly stable cleaning solution that generates a high concentration of hypochlorous acid during cleaning, and has sterilizing and washing out activity on bacteria and viruses. As means for achieving this object, a cleaning solution has been developed which is an aqueous solution containing hypochlorous acid and hypochlorite ions produced using a diaphragm-free electrolysis process. The effective residual chlorine concentration thereof and the hydrogen ion concentration exponent thereof are adjusted to a value from 500 ppm to 2000 ppm and to a value from pH 8.5 to pH 9.5, respectively. Thus, the cleaning solution remains stable for a prolonged period of time, and exhibits high sterilizing and wash-out activity during use.

Abstract: The present invention relates to a long-acting human growth hormone NexP-hGH protein and its production method. More specifically, it relates to a specific isoform of long-acting human growth hormone NexP-hGH protein in which human growth hormone is fused with a highly glycosylated alpha-1 antitrypsin mutant whereby long-acting properties in vivo are increased.

Abstract: Pharmaceutical composition for relieving fatigue and preparation method thereof. A pharmaceutical composition for relieving fatigue and preparation method thereof are provided. The pharmaceutical composition is prepared by mixing ethanol extract of ginseng, ethanol extract of astragalus, ethanol extract of epimedium, ethanol extract of yam, ethanol extract of polygonatum, ethanol extract of dodder, aqueous extract of wolfberry and a fermentation conversion solution of fruits and vegetables.

Abstract: A pharmaceutical composition for treating melasma is provided. The pharmaceutical composition is prepared from ginseng, salvia, mint, orange peel, peony, poria, licorice, peach seed, yam, penthorum chinense and a fermentation conversion solution of fruits and vegetables. A preparation method of the pharmaceutical composition is also provided.

Abstract: A delivery system for various functional compounds is disclosed. The delivery system incorporates a composition containing alumina. Various functional materials containing particular moieties may be adsorbed onto the alumina and used as desired. The functional compounds can be, for instance, pharmaceuticals, xenobiotics, anti-microbial agents, anti-viral agents, UV absorbers, odor control agents, fragrances, and the like. In one particular embodiment, for instance, certain dyes can be adsorbed onto the alumina surfaces. Once the dye is adsorbed onto the alumina surface, the resulting particles can be combined with a liquid vehicle for use in any suitable printing process.

Abstract: Biologically active substances and fractions of wheat germ ferment/fermented wheat germ extract (FWGE), including formulation A250, the processes for their production, the pharmaceutical preparations containing them, and their uses.

Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

Abstract: The invention concerns wheat germ ferment, its biologically active fractions, the process for their production, the pharmaceutical preparations containing them and their uses.

Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.

Abstract: A delivery system for various functional compounds is disclosed. The delivery system incorporates a composition containing alumina. Various functional materials containing particular moieties may be adsorbed onto the alumina and used as desired. The functional compounds can be, for instance, pharmaceuticals, xenobiotics, anti-microbial agents, anti-viral agents, UV absorbers, odor control agents, fragrances, and the like. In one particular embodiment, for instance, certain dyes can be adsorbed onto the alumina surfaces. Once the dye is adsorbed onto the alumina surface, the resulting particles can be combined with a liquid vehicle for use in any suitable printing process.

Abstract: The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors that are crucial for cell attachment, proliferation and functions. Biofunctional fibers could be fabricated into three-dimensional scaffolds. Polymer fibers described here comprise of biocompatible polymers that are either biodegradable ornon-biodegradable. This patent also describes a series of new biodegradable polyphosphoramidates for the processing of biodegradable fibers. Scaffolds made of non-biodegradable functional fibers could be used for in vitro cell culture (for example, ex vivo cell expansion), while biodegradable functional fibers could be fabricated into tissue engineering scaffolds.

Abstract: An anti-fouling agent derived by culturing Vibrio alginolyticus in a suitable aqueous solution as well as a newly isolated strain of V. alginolyticus (DSM 15590) for producing the anti-fouting agent. The anti-fouling agent can be used as a component to produce other anti-fouling compositions, Depending on the use, the anti-fouling agent derived from V. alginolyricus may be use directly, or subject to further purification.

Abstract: The present invention relates to a process of extracting haw pits by dry distillation and the device used therein. The process includes the following steps: removing the impurities of haw pits and drying them; immersing haw pits in water and then dripping and charging the dried pit into the furnace for dry distillation; gradually raising the temperature and dry distilling the haw pits at two temperature ranges of 105-195° C. and 305-380° C. respectively and collecting the distillate; mixing together the distillate, allowing them to separate into layers by specific gravity difference and separating out the final brownish red transparent liquor by siphon. The method of the present invention can provide high yield of extraction and the present device is simple in structure. Further, the present invention is easy to be employed on the industrial scale.

Abstract: The present invention relates to a method for the production of a dye preparation from madder root, comprising extraction of madder root in water at a temperature below 70-75° C., preferably below 65° C., while providing oxygen to the reaction mixture of madder root in water to obtain the dye preparation and to the dye preparation thus obtained.

Abstract: The invention relates to low-molecular weight, metabolism-activating mixtures of active ingredients from yeast fungi of the order Saccharomycetes and is characterized in that they are obtained from yeasts of the said order of Saccharomycetes, which are cultivated for some hours at temperatures starting at 37° C., are heated to a maximum of 45° C. and, following cooling, are subsequently processed in a manner known per se.

Abstract: A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

Abstract: A kit containing a plurality of sheets impregnated with a hydrating, non-ionic cleanser in a microwave-heatable container for use in bathing a patient or for personal bathing. In one embodiment, the sheets are preferably 9″×9″ in dimension, and made of a non-woven cotton or polyester/cotton blend. Alternatively, the sheets can be made in the form of mittens by joining the material so that one side remains open for the insertion of the hand of the user, and have an outer, absorbent layer and an inner, moisture-proof layer. The cleanser preferably is a mixture of de-ionized water, at least one non-ionic surfactant, a humectant and/or a hydrating emollient, and vitamin E that is intended to remain on the skin rather than be rinsed. The solution may also contain a preservative such as biguanide or be sterilized. In use, the kit is heated and then each sheet or mitten is applied to a separate portion of the body, to limit the risk of cross contamination.

Abstract: The present invention relates to the use of natural extracts of algae for the preparation of a product meant to prevent and to treat skin diseases. The invention also relates to natural extracts of algae meant to prevent and to treat these diseases. Said use of natural extracts of algae consists in using concentrated extracts of algae of the chlorella type. The invention especially applies to diseases such as skin rashes or allergic reactions to cosmetic compositions.

Abstract: The invention relates to low-molecular, metabolism-activating mixtures of active ingredients from yeast fungi of the order Saccharomycetes and is characterized in that they are obtained from yeasts of the said order of Saccharomycetes, which are cultivated for some hours at temperatures starting at 37.degree. C., are heated to a maximum of 45.degree. C. and, following cooling, are subsequently processed in a manner known per se.

Abstract: The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant of this novel strain contains effective insecticidal, antifungal and antibacterial agents. Also included in the invention is a solvent extractable, small molecular weight (<10,000 daltons) corn rootworm-active metabolite produced in the supernatant. Also included in the invention are methods of protecting or treating plants from fungal and bacterial infections and corn rootworm infestations comprising the step of applying to the plant an effective amount of the antibiotic/metabolite-producing novel Bacillus subtilis strain, the antibiotic/metabolite produced by the novel Bacillus subtilis strain or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide.

Abstract: The present invention relates to a novel antibiotic-producing and metabolite-producing Bacillus subtilis strain that exhibits insecticidal, antifungal and antibacterial activity. The supernatant of this novel strain contains effective insecticidal, antifungal and antibacterial agents. Also included in the invention is a solvent extractable, small molecular weight (<10,000 daltons) corn rootworm-active metabolite produced in the supernatant. Also included in the invention are methods of protecting or treating plants from fungal and bacterial infections and corn rootworm infestations comprising the step of applying to the plant an effective amount of the antibiotic/metabolite-producing novel Bacillus subtilis strain, the antibiotic/metabolite produced by the novel Bacillus subtilis strain or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide.

Abstract: Secretion of gastric acid and development of ulcers can be inhibited by administering to a patient in need thereof an effective amount of a hot water extract of the cultivated mycelia of Cordyceps sinensis.

Abstract: The present invention is directed to a unique strain of Bacillus subtilis for inhibiting growth of plant pathogenic fungi and bacteria and methods for treating or protecting plants from fingal and bacterial infections.

Abstract: This invention is a healthful composition comprising a hot-water extract of the cultivated mycelia of Cordyceps sinensis.The healthful composition of the invention is an oral healthful composition which is highly safe and has excellent cardiotonic, hypotensive, antitussive and anti-fatigue effects.

Abstract: Fucans with low molecular weight having anticoagulant, antithrombinic and antithrombotic activity.Fucan sulfates having molecular weight between 14000 and 29000 Dalton show a remarkable anticoagulant activity both in the global coagulation mechanism (APTT) and in the last phase of coagulation (antithrombinic activity). These compounds are useful also as antithrombotic drugs.

Abstract: Small particles and fines included along with larger subdivided solids are treated with water base liquid extraction medium to extract soluble solids therein in a process using milli-screens with milli-sized openings of less than about 0.095 inches across. The milli-screen openings may be kept open for the passage of liquids with specially-designed wipers and/or back-flushing from a liquid compartment and/or rotation of the milli-screen past the matrix of subdivided solids, the subdivided solids themselves acting as a screen cleaner. The invention is useful in batch or continuous diffusers for extracting soluble solids from subdivided solids containing small particles and fines.

Abstract: This invention relates to the extraction of biological compounds from plants and animals and to the preparation and tinctures and essences from the extracted materials. The materials are extracted using alcoholic and/or phosphate buffered saline solutions. The extraction step can be performed repeatedly on the residue from the previous step. The rich solution resulting from the extraction can be freeze dried for further use or employed as a fermentation feed. The fermenter product can be freeze dried for further use. The invention also makes use of the residues resulting from the extraction and fermentation reactions.

Abstract: The invention describes utilization of a cell culture of the strain of fungus Fusarium sambucinum Fuckel var. ossicolum (Berk. et Curt.) Bulai VSB-917 (All-Union Collection of Industrial Microorganisms of the VNIIgenetika Institute, collection code VKPM F-168) for application in the capacity of a producer of physiologically active substances for prophylactic and curative purposes.

Abstract: The present invention relates to a novel strain antibiotic-producing Bacillus subtilis which is effective against plant fungal and bacterial infections. The invention also includes methods of protecting plants from fungal and bacterial infections comprising the step of applying to the plant an effective amount of the antibiotic-producing Bacillus subtilis, the antibiotic produced by the antibiotic-producing Bacillus subtilis or a combination thereof, optionally further comprising another antibiotic-producing bacterial strain and/or a chemical pesticide. The invention includes methods of treating fungal and bacterial infections using whole broth cultures or supernatants obtained from cultures of antibiotic-producing Bacillus subtilis cultures. The invention also includes treating plant infections using a combination of whole broth and/or supernatant obtained from the antibiotic-producing strain of Bacillus subtilis optionally in combination with chemical pesticides.

Abstract: A skin whitening composition includes acerola cherry fermentate. The composition can be topically applied to the human skin and can include one or more whitening agents in combination with acerola cherry fermentate to achieve enhanced whitening effect. A method of whitening human skin includes topically applying to the skin acerola cherry fermentate in an amount and for a period of time sufficient to visibly whiten the skin. The method includes incorporating acerola cherry fermentate with known whitening agents and applying to the skin in an amount and for a period of time sufficient to visibly whiten the skin.

Abstract: Small particles and fines included along with larger subdivided solids are treated with liquid to extract soluble solids therein in a process using milli-screens with milli-sized openings of less than about 0.095 inches across. The milli-screen openings may be kept open for the passage of liquids with specially-designed wipers and/or back-flushing from a liquid compartment and/or rotation of the milli-screen past the matrix of subdivided solids, the subdivided solids themselves acting as a screen cleaner. The invention is useful in batch or continuous diffusers for extracting soluble solids from subdivided solids containing small particles and fines.

Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections containing an electrolyzed saline solution having a content of regulated amounts of ozone and active chlorine species. The ozone content is 5 to 100 mg/L (milligram per liter) and the chlorine species content is 5 to 300 parts per million (ppm). The active chlorine species comprises free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the active ingredients. The solution is used at an isotonic saline concentration and my be adjusted with hypertonic saline. The solution is used in vitro treatments of infected whole blood, blood cells or plasma to reduce contamination. The solution may also be administered to warm blooded animals, including humans by intravenous injection.

Abstract: The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.

Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors A.sub.1, A.sub.2, A.sub.3 and H, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.

Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.

Abstract: By irradiating a polyene antibiotic having a cis-type polyene structure with long wavelength ultraviolet light, it is possible to prepare the corresponding antibiotic having a trans-type polyene structure in high yield in a simple manner. Such antibiotics having a trans-type polyene structure exhibit strong antimicrobial activities and are useful as drugs for humans or animals.

Abstract: The invention is an improvement in isolating vancomycin from an aqueous solution of pH 5 to 9 which comprises separating the vancomycin from the solution by adding an alkali or alkaline earth metal inorganic salt to the solution.

Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors A.sub.1, A.sub.2, A.sub.3 and H, the additional salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.

Abstract: An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.

Abstract: This invention provides an improvement in the large scale processing of vancomycin which comprises the quiescent precipitation of vancomycin base from an aqueous solution of a pH of at least about 7.8.

Abstract: An antimycotic agent having a high degree of antimicrobial activity towards Eumycetes and with a level of toxicity lower than that of heptaene antibiotic V-28-3 is disclosed. This compound is a methyl ester derivative of heptaene antibiotic V-28-3.

Abstract: A method for resolving emulsions produced in preparation of pharmaceuticals by fermentation and in other such bioprocesses is disclosed. The method comprises adding an effective amount of a demulsifier to an emulsion containing fermentation product that includes a pharmaceutical which is desired to be extracted from the emulsion.

Abstract: A method for producing a novel antifungal product from a Pediococcus species is described. The preferred product (AFP) comprises a compound which contains valine and lactic acid and has a molecular weight of less than about 500 daltons. The product (AFP) is particularly useful in retarding fungal growth in foods and other materials in need thereof.

Abstract: A unique four-solvent system comprising methanol, dimethylformamide, methylene chloride and water is employed to provide an improved process for the purification and crystallization of amphotericin B.

Abstract: A water-soluble complex which is isolable from acid-precipitable material recovered from cultures of the bacterium, Achromobacter xerosis, and which is effective in inducing a variety of therapeutic responses commonly associated with biological responses modifiers and anti-inflammatory agents and which exhibits significant therapeutic activity in higher vertebrates at a dosage ranging from about 0.1 to about 25.0 mg/kg of body weight. Also disclosed are compositions containing such complexes, methods of preparation with such complexes and methods of treatment with compositions having such complexes.

Abstract: A process for purifying lysocellin which comprises mixing lysocellin solids with sufficient halogen acid to convert fatty acid ester salt impurities into water-soluble metal halogen salts and water-insoluble free fatty acids and to convert lysocellin salts into water-soluble metal halogen salts and water-insoluble lysocellin acid, separating the halogen salts from the lysocellin acid and fatty acid solids, mixing the lysocellin acid and fatty acid solids with sufficient caustic reagent to convert free fatty acids into water-soluble alkali metal salts and to convert lysocellin acid into a water-insoluble alkali metal lysocellin salts, and separating the water-soluble fatty acid alkali metal salts from the alkali metal lysocellin solids.

Abstract: Imidazole/vancomycin complexes are prepared by containing an imidazole, preferably imidazole or N-methylimidazole, with a member of the vancomycin family, preferably Vancomycin itself.The complexes are useful in the purification of vancomycin.

Abstract: The invention relates to high potency biomass-free avoparcin and a method for its preparation.

Abstract: Teichomycin A.sub.2 is recovered from whole culture fermentation broth of Actinoplanes teichomyceticus sp. or any similar microorganism producing Teichomycin A.sub.2 by extracting the broth with a water miscible solvent, such as acetone, acetonitrile, dimethylsulfoxide, n-propanol, methyl ethyl ketone or mixtures thereof.