Abstract: Disclosed is an ex vivo model for subcutaneous injection and aims at providing an in vitro method including the steps of i) immersing a skin explant in a solidifiable liquid matrix such that the upper face of the epidermis is not covered, which matrix is itself contained in a cell culture insert, the bottom of which consists of a porous membrane, and (ii) solidifying this matrix so as to trap the immersed portion of this skin explant, wherein the upper face of the epidermis is not covered, and adhering this same matrix to the side walls and the porous membrane of the insert, wherein the skin explant includes a thickness of at least 5 mm of hypodermis.

Abstract: Methods and compositions for rapid and efficient assembly of substrates (e.g., fibers) coated with lamellar vesicles are provided, wherein the vesicles are more strongly attached to the substrate than those made using other methods.

Abstract: Disclosed is a callus lysate containing a callus metabolite without a loss of callus metabolite and its preparation method, a capsule containing a callus lysate prepared through encapsulation by coating the callus lysate with a natural polymer material and its preparation method, and composition for external skin application and a cosmetic composition that includes the callus lysate or the capsule containing the callus lysate as an active ingredient, wherein the callus lysate of the present invention contains a large amount of a callus metabolite without a loss of callus metabolite and thus allows penetration or absorption of callus metabolite directly into the skin, thereby providing effects of the callus metabolite to prevent and improve various skin diseases and symptoms.

Abstract: Provided is a composition for oral administration, the composition including: a dispersion medium including: an aqueous solution; and a dispersed phase including: a population of particles, each particle including: a core including: a first active ingredient; and an aqueous solution; a shell, substantially surrounding the core, the shell including: a lipophilic carrier; and a plurality of emulsifying agents; wherein the particle retards the release of the first active ingredient after consumption.

Abstract: In some embodiments, an anti-aging composition includes hyaluronic acid, at least one anti-aging peptide, at least one skin penetration enhancer, and water. In some embodiments, an anti-aging composition includes hyaluronic acid, at least one anti-aging peptide, at least one tensing polymer, and water. An anti-aging product includes a skin mask patch and an anti-aging composition loaded into the skin mask patch. A method of forming an anti-aging product includes forming an anti-aging composition and loading the anti-aging composition into a skin mask patch.

Abstract: Various embodiments disclosed relate to water-based nail-treatment compositions including a first film-forming copolymer that is a copolymer of a (C1-C5)alkyl ester of methacrylic acid, of a (C1-C5)alkyl ester of acrylic acid, or a combination thereof, and of methacrylic acid. The nail-treatment compositions also include a second film-forming copolymer that is a copolymer of isophorone diisocyanate, a poly((C2-C3)alkylene oxide), and 2,2-bis(methylol)propionic acid. Methods of using the nail-treatment compositions and cured products of the same are also provided. A cured product of the nail-treatment composition can be monolithically peelable from the nail.

Abstract: Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for improving sallow-looking skin by enhancing bilirubin degradation in skin. The methods and compositions herein utilize one or more sucrose esters, which demonstrate a surprising ability to reduce bilirubin levels. The method involves applying a skin care composition containing an effective amount of a sucrose ester to a target portion of skin where a reduction in bilirubin level is desired.

Abstract: Disclosed herein are formulations, methods, and kits of formulations for inhibiting, ameliorating, delaying the onset of, reducing the likelihood of, treating, and/or preventing metabolic syndrome, and/or increasing energy levels. The formulations have at least one extract from a tart cherry, at least one antioxidant vitamin, at least one polyphenolic compound, and at least one prebiotic. Also disclosed are methods of making the formulations.

Abstract: Dental compositions that comprise algae are disclosed. Methods of use of the dental compositions, including methods of reducing plaque on at least one tooth of an animal using the dental compositions, are also disclosed.

Abstract: A method of treating skin is disclosed. The method can include topically applying to skin an effective amount of a composition that includes water, a Crithmum maritimum extract, and an Ulva lactuca extract.

Abstract: The invention pertains to a method for synthesizing a product of interest by culturing a microalgal cell obtained from a subterranean habitat for producing the product of interest. The microalgal cell obtained from a subterranean habitat can be cultured in the dark, in light, in low nutrition, or nutrient rich conditions for at least a portion of production cycle. A combination of these conditions can be used to specifically manipulate a microalgal cell culture to produce a product of interest. The product of interest can be a water-soluble carotenoid, for example, a water-soluble carotenoid produced by culturing an algae belonging to the genus Haematococcus or a capsular exopolysaccharide produced by culturing an algae belonging to the genus Parachlorella. Compositions containing the water-soluble carotenoid, for example, as sunscreen and compositions containing the exopolysaccharide, for example, as moisturizing cream are also described.

Abstract: Provided is a composition for oral administration, the composition including: a dispersion medium including: an aqueous solution; and a dispersed phase including: a population of particles, each particle including: a core including: a first active ingredient; and an aqueous solution; a shell, substantially surrounding the core, the shell including: a lipophilic carrier; and a plurality of emulsifying agents; wherein the particle retards the release of the first active ingredient after consumption.

Abstract: Provided is a composition for oral administration, the composition including: a dispersion medium including: an aqueous solution; and a dispersed phase including: a population of particles, each particle including: a core including: a first active ingredient; and an aqueous solution; a shell, substantially surrounding the core, the shell including: a lipophilic carrier; and a plurality of emulsifying agents; wherein the particle retards the release of the first active ingredient after consumption.

Abstract: A pharmaceutical composition includes a hot-water extract of Codium fragile as an effective ingredient for treating or preventing arthritis, which is a highly effective natural product-derived composition available for cosmetics, beverages, functional foods, etc. which are expected for the alleviation of arthritis.

Abstract: Compositions for reducing skin aging are disclosed herein. The compositions can be topically applied to a skin region to reduce or prevent skin wrinkles, fine lines, thinning skin, sagging skin, skin dryness, and skin itchiness.

Abstract: A method of treating a vulnerable atherosclerotic plaque can include identifying the vulnerable atherosclerotic plaque and administering a sulfated polysaccharide, or a pharmaceutically acceptable salt thereof, to a subject in an amount and at a frequency sufficient to stabilize and reverse a vulnerable atherosclerotic plaque.

Abstract: Nutraceutical compositions and the methods for preventing and/or mitigating veisalgia by the administration thereof. The nutraceutical compositions address the challenged state of the individual and potentiate their ability to be compliant with treatment when the metabolic functions of the liver are overwhelmed as alcohol metabolism depletes hepatic supplies of needed molecules. The methods provide the nutraceutical composition directly to the end organs where alcohol and toxin infused blood is also metabolized and neutralized.

Abstract: The present invention provides a composition for treating skin damage, comprising Halobacteria extracts and Dunaliella extracts. The aforementioned extracts further comprising strong antioxidants with high redox potential when dissolved in oil and in water. The strong antioxidants inhibiting in a known oxidative mechanisms which are further correlated with skin damage, wherein the Halobacteria extract is Archaebacteria DN-1 having a wide range impact on rehabilitation of the skin tissue after radiation, and wherein said Halobacteria extracts and Dunaliella extracts combination promotes rehabilitation of the skin tissue after radiation, and provides a synergistic effect on a mammalian skin. Furthermore, the composition is preferably adapted for topical delivery.

Abstract: There is provided the use of a functional thylakoid extract, particularly in admixture with a physiologically acceptable carrier, in pharmaceutical application, in the treatment of cardiovascular diseases, and method for the treatment thereof. The cardiovascular diseases (CVD) may comprise several diseases associated with inflammation of the heart or arteries and include coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack), atherosclerosis, stroke, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, heart arrhythmia, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, and venous thrombosis.

Abstract: The present invention relates to an extract of algae from the order of ulvales, in particular an extract of green algae of the Ulva type, for its use for modulating the immune response in a human being or an animal, in particular for stimulating the immune response with view to infections. It also relates to the non-therapeutic use of an extract of green algae of the Ulva type for modulating the immune response.

Abstract: The present invention provides a novel lactic acid bacterium having antioxidant and anti-aging functions and a dementia alleviation effect, and more specifically, provides Lactobacillus pentosus var. plantarum C29 KCCM11291P and Lactobacillus curvatus C3 KCCM430009. In addition, the present invention provides an antioxidant and anti-aging pharmaceutical composition and a dietary supplement containing the Lactobacillus pentosus var. plantarum C29 KCCM11291P or Lactobacillus curvatus C3 KCCM430009 of the present invention as an active ingredient, and a composition for preventing or treating dementia and a dietary supplement for preventing or alleviating dementia, containing Lactobacillus pentosus var. plantarum C29 KCCM11291P or Lactobacillus curvatus C3 KCCM430009 as an active ingredient. Additionally, the present invention provides a composition for preventing or treating dementia, containing a fermentation composition, as an active ingredient, fermented by Lactobacillus pentosus var.

Abstract: Provided is a technique for enhancing the absorption of fucoidan into the body and elevate various effects of fucoidan by using a fucoidan preparation that is characterized by containing fucoidan and zinc and the ratio of zinc to fucoidan being 0.005% or greater.

Abstract: The present invention relates to an algal extract comprising sulphated and non-sulphated polyanionic polysaccharides, to a method for preparing an algal extract as well as to its therapeutic and prophylactic applications.

Abstract: A medicament for use in treating tuberculosis, the medicament is a glycoprotein, a mixture of polysaccharide and protein, a polypeptide or a protein.

Abstract: A system and method for separating nutrients, such as phosphorus and protein, from biological materials may be disclosed. Biological material, for example in the form of wet solids from raw manure, may first be separated out by a solid-liquid separator. The wet solids may then be dissolved in an acidic solution. The resulting supernatant from the acidic treatment may then be separated and phosphorus reclaimed therefrom. The resulting precipitate from the acidic treatment may be separated from the supernatant and treated with a basic solution. The resulting supernatant following the basic treatment may then be separated and protein reclaimed therefrom. In some embodiments, the supernatant resulting from the acidic treatment may itself be alkalinized, creating a precipitate which contains phosphorus solids and a supernatant which can be separated from the phosphorus solids and used as the basic solution with which to treat the precipitate resulting from the acidic treatment.

Abstract: A system and method for separating nutrients, such as phosphorus and protein, from biological materials may be disclosed. Biological material, for example in the form of wet solids from raw manure, may first be separated out by a solid-liquid separator. The wet solids may then be dissolved in an acidic solution, which may be created directly or by fermentation. The resulting supernatant from the acidic treatment may then be separated and phosphorus reclaimed therefrom. The resulting precipitate from the acidic treatment may be separated from the supernatant and treated with a basic solution. The resulting supernatant following the basic treatment may then be separated and protein reclaimed therefrom.

Abstract: The present invention relates to compositions comprising fermented seaweed and/or algae. The invention also relates to processes for providing such compositions, wherein the fermentation times are prolonged to increase bioavailability of the nutrients.

Abstract: A method for treating a disease associated with transcription activation by NF-?B by administering a composition for inhibiting transcription activation by NF-?B to a patient in need of treatment of the disease. The composition contains a fraction having a molecular weight of 3,000 or less obtained by purifying a water extract of Sargassum horneri as an active ingredient.

Abstract: The invention is directed to a method of treating a wound (e.g., to suppress scar formation) in an individual in need thereof comprising contacting the wound with an effective amount of a composition comprising (i) Wharton's jelly stem cells (WJSCs), (ii) a cell culture medium that has been conditioned with WJSCs, (iii) a lysate of WJSCs, (iv) a cell culture medium that has been conditioned with WJSCs exposed to apoptotic skin cells and keloid cells, or (v) a combination thereof. The invention is directed to a medical dressing (e.g., pharmaceutical compositions) comprising Wharton's jelly stem cells (WJSCs), a cell culture medium that has been conditioned with WJSCs, a lysate of WJSCs, a cell culture medium that has been conditioned with WJSCs exposed to apoptotic skin cells and keloid cells, or a combination thereof.

Abstract: The invention relates to a topical veterinary composition for animals. It is characterized in that it comprises, in a physiologically acceptable medium, extracts of boldo Peumus boldus and extracts of meadowsweet Spiraea ulmaria. The invention applies in particular to preventing or treating or to assisting with the control of microbial infections.

Abstract: The present invention relates to a composition for the prevention or treatment of arthritis, the composition containing a Sargassum serratifolium extract as an active ingredient. The extract of Sargassum serratifolium according to the present invention has an excellent activity to reduce or inhibit the activity of IL-1?, IL-6, or TNF-?, which is an inflammatory cytokine, and has an excellent effect alleviating arthritis in an arthritis animal model so that it can be usefully used as a composition for treating arthritis. In addition, there is no cytotoxicity, and toxicity to the drug and side effects are avoided so that it can be safely used even for long-term use, and it is stable in the body.

Abstract: The present disclosure relates to compositions and related methods to reduce body weight, body fat, waist and hip size, plasma total cholesterol, LDL, triglycerides, blood glucose, leptin and C-reactive protein levels and increase in HDL and serotonin levels in an mammal. The LeptiCore® formulation disclosed, at both the low and high dosages, is helpful in the management of fat gain and its related complications. The higher dosage resulted in significantly greater reductions in body weight and triglyceride, blood glucose, and C-reactive protein levels, as well as increased serotonin levels.

Abstract: The present disclosure relates to compositions and related methods to reduce body weight, body fat, waist and hip size, plasma total cholesterol, LDL, triglycerides, blood glucose, leptin and C-reactive protein levels and increase in HDL and serotonin levels in an mammal. The LeptiCore® formulation disclosed, at both the low and high dosages, is helpful in the management of fat gain and its related complications. The higher dosage resulted in significantly greater reductions in body weight and triglyceride, blood glucose, and C-reactive protein levels, as well as increased serotonin levels.

Abstract: The present invention discloses isolates and fractions from a phyto-percolate and methods for affecting various cytokines by administering an effective amount of one or more of said isolates or fractions to an animal. In various exemplary embodiments, the isolates are useful for the treatment of bovine, canine and swine infection or inflammation, including bovine mastitis, by regulation of TNF-a, lactoferrin, IFN-?, IL-I ?, serum amyloid-A (SAA), IL-6 and/or ?-defensin associated with infection or an immune response generally.

Abstract: A method for treating a cancer in a mammal using an extract of a Phoenix dactylifera (i.e. date) fruit flesh is described, along with an extraction method. The extract may be formed into a dried powder and reconstituted into a variety of media for oral administration, intravenous administration, or other routes. The extract may also be administered to prevent the occurrence of cancer or to treat other ailments.

Abstract: A method for the color retention of dyed keratin fibers is provided herein. The method includes i. applying a cosmetic composition to dyed keratin fibers as a pretreatment agent for keratin. The method further includes ii. subjecting the keratin fibers to a dyeing and/or brightening within a period of about 5 seconds to about 24 hours after to step i. The cosmetic composition has, based on its own weight, from about 0.01 to about 4.00% by weight of at least one alum and a pH value in the range of about 2.5 to about 5.

Abstract: The present invention relates to a formulation comprising Propolis, Ginseng root and Zingiber officinale extracts to be used in the treatment, prevention of various respiratory diseases or alleviation and/or elimination of symptoms thereof and a method for preparing said formulation.

Abstract: The present invention provides a composition for preventing, improving or treating periodontal diseases comprising extract of mangosteen. The composition of the present invention has excellent anti-bacterial and anti-inflammatory effects against bacteria inducing periodontal diseases as comprising extract of mangosteen, or alpha-mangosteen or gamma-mangosteen derived from thereof, and thereby it can be widely used for medicines and foods for preventing, improving or treating periodontal diseases.

Abstract: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.

Abstract: The present invention provides 11 peptides represented as SEQ ID NO: 1-11. The peptides have the ability of anti-virus and bacteria, and can reduce infections, clean necrotic tissue, and promote debridement so as to facilitate wound healing. Moreover, the peptides can also induce collagen secretion and activate fibroblasts and keratinocytes so as to stimulate angiogenesis. Thus, the peptides of the present invention are suitable for development as a health caring product to help an individual enhance recovery and immunity.

Abstract: The instant invention provides a method and composition for treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, said method comprising administering effective amounts of Boswellia Serrata, effective amounts of freeze dried green lipped mussle, effective amounts of white willow bark extract containing salicin, effective amounts of angelica root, effective amounts of glucosamine and salts thereof, effective amounts of chondroitin and salts thereof and effective amounts of omega 3 fatty acids.

Abstract: A method for treating neurodegenerative diseases including the step of administering an isothiocyanate functional surfactant to an area affected by a neurodegenerative disease, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

Abstract: The present invention relates to a method for treating plant pests or pathogens. The disclosed method of protecting plants against pests includes a plant protection composition, wherein the plant protection composition comprises a water-soluble activator and a benefit active precursor. The composition is applied externally to the plant where a benefit active species is generated in situ, thus mitigating the pest.

Abstract: A composition comprising an extract from damaged plant parts from the Moringaceae genus, at least one oligopeptide, at least one extract from the Laminaria genus, and whey protein and a method for stimulating collagen synthesis in skin cells.

Abstract: Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition comprising ethanol and isopropanol is applied to the surface. In other embodiments, two or more ethanol compositions are applied and removed sequentially from the surface prior to contacting the surface with a biological fluid, tissue or vessel, wherein the composition in each successive administration comprises an increased amount of ethanol. Also provided is a method of reducing a microbial infection of a surface comprising applying a mucilage extract from an Opuntia ficus indica species to the surface.

Abstract: There is provided pet food comprising astaxanthin and/or an ester thereof as an active component and having an effect of deodorizing excrement such as urine and feces, effects of improving sleep, sensibility such as perception and cognition, and visual sense, and an effect of treating, improving or preventing diabetes and diabetic complications. The pet food can deodorize excrement such as urine and feces, improve sleep, sensibility such as perception and cognition, and visual sense, and treat, improve or prevent diabetes and diabetic complications.

Abstract: The present invention relates to a novel pharmaceutical composition free of gastric coating comprising anagrelide hydrochloride in combination with a non-pH dependent polymer and a pharmaceutically acceptable water soluble acid and its use for the treatment of essential thrombocythemia.

Abstract: Described is the use of soluble indigestible fiber for inducing lysis of the cell walls of eukaryotic microalgae in the lumen of the intestine of an omnivorous or carnivorous animal including an intestinal flora and also for synergistically increasing the effect of the indigestible fiber in the induction of the growth of the intestinal flora of an omnivorous or carnivorous animal. The subject matter of the invention is also the composition intended for this use and for a method of improving the health or of food supplementation.

Abstract: A scalable and sustainable process for production of renewable chemicals and biofuel from seaweed in its own juices or in seawater without desalination of the seaweeds is provided herein. The process as disclosed in the preset invention is an eco-friendly process for production of renewable chemicals and biofuel with an easy method of disposing of the waste streams. Further, the process as disclosed in the present invention is cost effective, suitable since transporting and storing the raw material obtained in the form of slurry of the seaweeds because of its lesser bulk is easy, easier handling due to its free flowing nature and its direct use for further processing to obtain renewable chemicals and/or biofuel.

Abstract: A composition comprising an extract from damaged plant parts from the Moringaceae genus, at least one oligopeptide, at least one extract from the Laminaria genus, and whey protein and a method for stimulating collagen synthesis in skin cells.