Abstract: The disclosure generally relates to methods of treating an ocular disease, comprising administering an effective amount of a pharmaceutical composition to an eye of a subject in need thereof, wherein the pharmaceutical composition comprises nintedanib, or its salt, derivative, analog or polymorph, or combination thereof. The disclosure also relates to pharmaceutical composition or formulation, which can be used for treating ocular diseases. In another aspect, the disclosure provides method of making the pharmaceutical composition or formulation.

Abstract: The invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising: •(i) a step of applying an oxidized polysaccharide, •(ii) a step of heating to a temperature of at least 100° C., •(iii) a step of applying a compound (I) •Ri—CHOH—CH(NH—COY)(CH2OH) (I). The invention also relates to a cosmetic composition comprising an oxidized polysaccharide and a compound (I) for which Y?H and to kits. The process makes it possible to obtain good hair-conditioning cosmetic properties, with a long-lasting effect.

Abstract: The present invention relates to a stable fixed dose aqueous pharmaceutical composition (e.g., contained in a container) for nasal administration to a human, comprising mometasone or its salt, olopatadine or its salt. The composition may further include a hydrocolloid. The invention also relates to a process for preparing the pharmaceutical composition, and the use of the pharmaceutical composition in the treatment of rhinitis in a subject.

Abstract: The invention concerns nanocapsules in the form of a colloidal suspension or in dry form, said nanocapsules comprising at least an active ingredient in the form of an oil, one ionic surfactant, optionally one nonionic surfactant, and one hydrophilic polymer. The invention also concerns their manufacture and their uses.

Abstract: The present disclosure relates to compositions that protect the skin and hair from extreme heat (external thermal flux). The compositions include: (a) laponite; (b) one or more UV filters; (c) one or more emulsifiers; and (d) water. The compositions are useful in cosmetic, industrial, and military technologies. For instance, the compositions are useful in methods for protecting skin from intense external thermal flux (e.g., fires and explosives). When applied to the hair, the compositions are useful in methods for protecting the hair from heat damage caused by, for example, hair dryers, curling irons, straightening irons, etc.

Abstract: Zinc oxide compositions and methods for applying anti-reflective coating on oxide particles for sunscreen applications are provided herein. A method includes selecting one or more coating materials to be applied to zinc oxide particles in a sunscreen composition, wherein selecting is based on optical properties of the coating materials, wherein the optical properties comprises at least the refractive index of each of the coating materials, and applying the selected coating materials to the zinc oxide particles to create the sunscreen composition.

Abstract: Cosmetic composition comprising at least 35% by weight of a powder component and a binding component characterized in that it comprises at least one ester selected from neopentylglycol dipelargonate, glycerol tripelargonate, pentaerythritol tetrapelargonate and mixtures thereof.

Abstract: Zinc oxide compositions and methods for applying anti-reflective coating on oxide particles for sunscreen applications are provided herein. A method includes selecting two or more coating materials to be applied to zinc oxide particles in a sunscreen composition, wherein selecting is based on optical properties of the coating materials, wherein the optical properties comprises at least the refractive index of each of the coating materials, and applying the selected coating materials to the zinc oxide particles to create the sunscreen composition.

Abstract: A method of producing a multi-layer beauty care product for applying a skin active agent to the skin. The method involves applying a water-soluble fluid to a transfer substrate. The water-soluble fluid contains a skin active agent and is applied to the transfer substrate through an image carrier having a mesh size of 40 to 500. The water-soluble fluid is dried to form a water-soluble film, which is then transferred to a backing layer coated with a pressure sensitive adhesive. The resulting multi-layer beauty care product provides a suitable a means of delivering the skin care active agent to a target portion of skin.

Abstract: Provided is a beauty care pack including a release film and a beauty care sheet which is separably attached to the release film, wherein the beauty care sheet comprises: a support; a fiber layer which is laminated on the support and in which water-soluble polymers are formed in the form of a nanofiber web; a moisturizing layer which is laminated on the fiber layer and consists of the water-soluble polymers and moisturizing materials; and a beauty care layer which is laminated on the moisturizing layer and in which the water-soluble polymers and functional materials are formed in the form of a nanofiber web, such that active ingredients are absorbed into the skin while being dissolved by moisture.

Abstract: Composition comprising avermectin compounds without solid fatty substances The invention relates to a dermatological or pharmaceutical composition comprising at least one aqueous phase and at least one active phase comprising at least one active compound chosen from avermectin compounds and at least one solvent and/or propenetrating agent of avermectin compounds, where the composition comprises less than 3% by weight of solid fatty substances at room temperature and at atmospheric pressure, relative to the total weight of the composition. The invention relates also to the composition for use in the treatment of rosacea, of common acne, of seborrheic dermatitis, of perioral dermatitis, of acneiform rashes, of transient acantholytic dermatosis, of acne necrotica miliaris and of atopic dermatitis, and preferably for use in the treatment of rosacea. Finally, the invention relates to a method for preparing the composition.

Abstract: Composition comprising avermectin compounds without solvents and propenetrating agents of avermectin compounds The invention relates to a dermatological or pharmaceutical composition comprising at least one aqueous phase and at least one fatty phase comprising one or more fatty compounds different from solvents and/or propenetrating agents of avermectin compounds and a least one active compound chosen from avermectin compounds, where the composition comprises neither solvents nor propenetrating agents of avermectin compounds. The invention relates also to the composition for use in the treatment of rosacea, of common acne, of seborrheic dermatitis, of perioral dermatitis, of acneiform rashes, of transient acantholytic dermatosis, of acne necrotica miliaris and of atopic dermatitis, and preferably for use in the treatment of rosacea. Finally, the invention relates to a method for preparing the composition.

Abstract: Lip compositions, in particular lip oil compositions, capable of forming a multilayer structure after application to lips including at least two immiscible components prior to application, wherein the at least two immiscible components are Component A which includes 0.01% to 30% by weight with respect to the total weight of the composition of at least one film forming agent and Component B which comprises 0.001% to 90% by weight with respect to the total weight of the composition of one or more silicone compounds in amounts sufficient to achieve a viscosity of 1000 cSt to less than 100,000 cSt are provided, as well as methods of applying such compositions to lips.

Abstract: The present invention relates to compositions and methods for treating fat deposit accumulation in a subject. The invention provides a non-surgical method for reducing fat deposits comprising administering an effective amount of a fat-lysing concentration of one or more of cholate and chenodeoxycholate in a pharmaceutically acceptable formulation to the subject in need thereof.

Abstract: There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene component.

Abstract: The present invention, belonging to the technical field of chemical sun-screening agent preparation, discloses a high-ultraviolet absorption lignin/chemical sun-screening agent microcapsule using lignin as a wall material and a preparation method therefor. The method of the present invention comprises the following steps: (1) dissolving 1-20 parts by weight of lignin in 100-200 parts by weight of an aqueous solution with a pH of 12, adjusting the pH of the solution to 7-10, and then removing insoluble substances by filtration to obtain a lignin solution; and (2) mixing 10-50 parts by weight of the lignin solution in step (1) with 1-10 parts by weight of a chemical sun-screening agent, and performing ultrasonic radiation under a power of 200-1500 W for 10 s to 25 min to obtain a lignin/chemical sun-screening agent microcapsule emulsion.

Abstract: Anhydrous antiperspirant stick or soft solid composition comprising an antiperspirant active system, thickening agent, and non-aqueous carrier oil, characterised in that the particulate antiperspirant active system comprises an aluminium sesequichlorohydrate of formula Al2(OH)4.4Cl1.6 to Al2(OH)4.9Cl1.1 activated with a water soluble calcium salt.

Abstract: A deodorant composition comprising ethylhexylglycerol, triethyl citrate and BHT, wherein the ratio of ethylhexylglycerol to triethyl citrate is from 1:6 to 1:1 by weight and wherein the ratio of BHT to the sum of ethylhexylglycerol and triethyl citrate is from 1:40 to 1:5 by weight.

Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

Abstract: The compositions of the various embodiments include benzoyl peroxide and Hest G-18-0. The methods of this invention include treating acne, increasing the solubility of benzoyl peroxide, and treating the skin. Embodiments are also directed to a dual chamber package comprising a chamber for benzoyl peroxide and a chamber for Hest G-18-0.

Abstract: Suggested are liquid cooling compositions, containing (a) L-Menthol, (b) D-Menthol, and (c) at least one further cooling agent, selected from the group consisting of isomenthol, menthyl acetate (L), menthyl acetate (D), menthyl acetate (iso), acetic acid menthyl lactate (iso) and acetic acid menthyl lactate (neo) with the proviso that in case that component (c) represents Isomenthol, the compositions do not contain any alkanediols.

Abstract: The present invention relates to a cosmetic composition comprising one or more amino silicones, one or more cationic surfactants and one or more esters of formula R?—O—CO—R—CO—O—R?. The invention also concerns a cosmetic treatment process for keratin substances, in particular for conditioning hair, implementing said cosmetic composition.

Abstract: The invention proposes to use a plant material derived from Marrubium vulgare for a non-therapeutic cosmetic treatment for tightening skin pores, said plant material comprising an effective amount of Forsythoside B as the active molecule. The plant material is preferably constituted of a cellular extract of dedifferentiated plant cells freed from cellular debris. This treatment is particularly intended for refining skin grain and/or for treating skin with an oily tendency.

Abstract: The present application relates to topical compositions. In particular, the present application relates to a topical composition comprising retinoid as active agent, and pharmaceutically acceptable excipient(s), and a process of preparing such compositions. Further, the present application relates to method of using topical compositions for the treatment of skin disorders such as acne, rosacea, psoriasis etc.

Abstract: A non-aqueous composition and method for reducing the drying time of wet hair includes applying added water to human hair to obtain wet hair and applying a nonaqueous serum comprising a combination of about 55 to about 65 percent by weight of at least one volatile silicone compound, about 30 to about 40 percent by weight of at least one high molecular weight silicone elastomer, a thermoprotective agent, an emollient, and a conditioning agent; applying the nonaqueous serum and heat to the wet hair in order to remove from about 80% to about 100% of the added water. In one embodiment, the application of the serum is capable of reducing a drying time of the wet hair by at least 25 percent.

Abstract: The present specification relates to an oil-in-water type emulsion cosmetic composition containing an amphiphilic anisotropic powder and ceramide, wherein the amphiphilic anisotropic powder contains a first polymer spheroid which is hydrophilic and a second polymer spheroid which is hydrophobic, wherein the first polymer spheroid and the second polymer spheroid bind by at least partially penetrating the other polymer spheroid, wherein the first polymer spheroid has a core-shell structure, wherein the shell contains a functional group, and wherein the ceramide contains oil phase ceramide included in oil phase and ceramide particles included in water phase.

Abstract: Personal care compositions containing active ingredients and an anti-irritant combination of aloe and taurine are disclosed. Methods of preparing the personal care composition and uses of the personal care composition are also disclosed.

Abstract: The invention relates to topical sunscreen emulsion comprising an oil phase and a water phase, wherein said emulsion comprises a phosphate ester emulsifier, phytantriol and an amount of at least 1 wt.-% based on the total weight of the topical sunscreen emulsion of at least one UV-filter substance. Furthermore, the invention relates to the use of phytantriol for improving the water resistance of such topical sunscreen emulsions.

Abstract: Described herein are complexes comprising a cationic antibacterial agent and a metal salt; oral care compositions comprising same; along with methods of making and using these complexes and compositions.

Abstract: The disclosed invention relates to soil and water treatment compounds, specifically to an acidifying composition used to treat soil or irrigation water used for growing plants. Disclosed is an acidifying composition that includes an organic acid. The acidifying composition is used to control and manage conditions in irrigation water and soil to prevent sodic deterioration of soil structure. Treatment of soil and/or irrigation water with the disclosed acidifying composition leads to improved soil quality and improved quality of plants grown in the soil treated with the acidifying composition.

Abstract: An organopolysiloxane emulsion composition which contains a polyoxyalkylene-modified organopolysiloxane compound represented by formula (1) as an emulsifying agent or as an emulsifying assistant. (LR2SiO1/2)a(R3SiO1/2)b(R2SiO2/2)c(RSiO3/2)d(SiO4/2)e??(1) (In the formula, L represents a polyoxyalkylene group represented by formula (2); R represents a hydrogen atom, a hydroxy group, an alkyl group, an aryl group, an aralkyl group or an alkoxy group; a represents a number of 2-4; b represents a number of 0-2; c represents a number of 50-1,000; and each of d and e represents 0 or 1.) —H2C—CH2—(CH2)r—O-(EO)s-(AO)t—R1??(2) (In formula (2), EO represents an oxyethylene group; AO represents a linear or branched oxyalkylene group having 3-10 carbon atoms; R1 represents an alkyl group, a hydrogen atom, a carboxy group, an acyl group or a phenyl group; r represents a number of 0-10; s represents a number of 1-100, t represents a number of 0-150; and (s+t) represents a number of 15 or more.

Abstract: The present disclosure relates to novel crystalline forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino} acetic acid and processes for preparation and uses thereof. Crystalline form CS1, form CS2 and form CS8 of the present disclosure can be used for preparing drugs treating anemia, which providing new choices for preparing drugs of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino} acetic acid, and having very important value for drug development.

Abstract: The invention relates to a dermatological or pharmaceutical composition comprising at least one aqueous phase, at least one fatty phase comprising one or more fatty compounds and at least one active phase comprising one or more active compounds chosen from avermectin compounds and one or more solvents and/or propenetrating agents of avermectin compounds, where the composition does not comprise gelling agent. The invention relates also to the composition for use in the treatment of rosacea, of common acne, of seborrheic dermatitis, of perioral dermatitis, of acneiform rashes, of transient acantholytic dermatosis, of acne necrotica miliaris and of atopic dermatitis, and preferably for use in the treatment of rosacea. Finally, the invention relates to a method for preparing the composition.

Abstract: The present invention generally relates to systems and methods for treating vitiligo. In one set of embodiments, the present invention comprises a composition comprising pyruvic acid and/or a pyruvate salt. The composition may be formulated for application to the skin of a subject, for instance, as a gel, lotion, cream, ointment, soap, or stick. In some cases, the composition may comprise a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present as a liquid crystal, and/or in liposomes, micelles, or other vesicles. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Abstract: The present invention provides a peptide having skin-whitening activity. The peptide of the present invention exhibits an excellent skin whitening effect by inhibiting melanogenesis, inhibiting the activity of tyrosinase, inhibiting the expression of melanosis-involved factors, and inhibiting melanosome transfer. The peptide of the present invention has excellent skin permeability due to the small size thereof. Excellent activity and stability of the foregoing peptide of the present invention can be very favorably applied to cosmetics.

Abstract: The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase.

Abstract: There are provided, inter alia, novel stabilized compositions for treating skin conditions wherein a therapeutically effective dosage of sulfur compound is applied which results in healing. The utilized dosage of sulfur compound results in a quicker breakdown of the virus capsid structure, resulting e.g., in faster healing. The dosing regimen to maintain the concentrations of the sulfur containing amino acid at the affected site also helps achieve quicker healing. The formulations and the methods are applicable to a variety of skin conditions including cold sores, herpes, genital herpes and shingles.

Abstract: Lip compositions, in particular lip gloss compositions, capable of forming a multilayer structure after application to lips are provided, as well as methods of applying such compositions to lips.

Abstract: The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients. The formulation process removes metal ions, reduces ionic strength, controls pH, and reduces exposure to air, thus improving stability and lengthening shelf-life.

Abstract: A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.

Abstract: The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.

Abstract: The present disclosure relates to compositions containing a natural extract(s) and their fraction(s) and the use of such compositions for treatment of skin, hair and nail. For example, the present disclosure relates to compositions containing an aqueous extract of (i) Yacon leave, (ii) Amor Seco leave, or (iii) Porphyridium biomass, or a combination thereof and a pharmaceutically or cosmetically acceptable carrier use on hair skin and nails for cosmetic purposes.

Abstract: An organopolysiloxane that can suppress swelling of a container due to a hydrogen gas derived from Si—H groups and occurrence of an offensive odor derived from aliphatic unsaturated groups, and that is excellent in emulsification stability and has good cosmetic durability, and a cosmetic containing the same. The organopolysiloxane being represented by the following average formula (1): wherein, R1 represents a group selected from an alkyl group having 1 to 30 carbon atoms, etc., R2 represents a divalent organic group having 2 to 15 carbon atoms, R3 represents any of a hydrogen atom and an alkyl group having 1 to 30 carbon atoms, R4s each independently represent a group selected from an alkyl group having 2 to 30 carbon atoms and another organopolysiloxane, “a” is 1 to 500, “b” is 1 to 10, and “c” is 1 to 10.

Abstract: Described is a skin benefit cosmetic composition having a functionalized solvent and 12-hydroxystearic acid. The composition is at least substantially transparent and yields excellent skin benefits when topically applied.

Abstract: A delayed release delivery system comprises a hydrophilic core particle having surface pores and containing a liquid. The particle is encapsulated in a polymer having a hydrophobic backbone and hydrophilic pendant groups. At least some of the surface pores adjacent the hydrophilic pendant groups are blocked in the presence of water and unblocked in the absence of water. The treated particle contains liquid in a weight ratio of the liquid to the porous core particle of at least 400:1.

Abstract: A topical composition comprising a Polymer, a high molecular weight hyaluronic acid (HWM HA) and/or its salt, a low molecular weight hyaluronic acid (LWM HA) and/or its salt, and a polyamino acid and/or its salt; and water and a method for identifying a test polymer that forms a micro-mesh structure when combined with such ingredients.

Abstract: The present invention provides a composition comprising (i) about 0.05 to about 0.5% by weight retinol; (ii) a polar emollient selected from the group consisting of propylene glycol stearyl ether dicaprylyl carbonate, propylene glycol isostearate and combinations thereof; and (iii) isohexadecane, wherein the weight ratio of polar emollient to isohexadecane is 1:1 or lower and the composition is anhydrous.

Abstract: A novel method of applying topical erectile dysfunction medicaments for controlled dispensing thereof through a condom or like prophylactic article is provided. Additionally, encompassed within this invention is the combination of an initial ingestion of a small dose of orally taken ED medicament for initial generation of nitric oxide followed by such a topical application. With such a method, the initial oral application metabolizes and runs its course while the topical application provides the needed dose of ED medicament. Once a sexual event is completed, the wearer may then remove the topical application article removing the topical delivery thereof in order to return to a flaccid state quickly and easily. Such an article and method thus reduces the propensity for potentially damaging excessive erection states and provides a more reliable dosing regimen for more effective and safe implementation of such an ED medicament program.

Abstract: Provided is a composition comprising one or more protein and one or more polyalkoxy fatty compound wherein the weight ratio of said protein to said polyalkoxy fatty compound is from 0.

Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/soluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.