Preparations Characterized By Special Physical Form Patents (Class 424/400)
  • Patent number: 10688043
    Abstract: The present invention includes pourable, non-toxic lubricating compositions containing carrageenan and more precisely ? carrageenan as an anti-viral agent, for protection from Human Papillomavirus (HPV), and methods of using the lubricating compositions as a non-oily, psuedoplastic lubrication product and administering the carrageenan for reducing the propagation of HPV during sexual activity.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: June 23, 2020
    Inventor: Mario Elmen Tremblay
  • Patent number: 10688028
    Abstract: Solid stick antiperspirant compositions include an antiperspirant active, one or more waxes, and a plurality of liquids. The one or more waxes include a polar wax. The plurality of liquids include about 60% or greater, by weight of the plurality of liquids, of a non-volatile silicone. The solid stick antiperspirant composition is substantially or completely free of volatile silicones. Antiperspirant product containing solid stick antiperspirant compositions are also described herein.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 23, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Elton Luis Menon, David Frederick Swaile
  • Patent number: 10682307
    Abstract: The present invention relates to a gastric retention active delivery system in the form of a coated capsule, which, in contrast to prior art delivery systems exhibiting relatively poor floating-properties, and thus requiring size expansion capability in order to securely delay passage through the pylorus, reliably stay afloat for several hours. This is achieved by combining pore forming components and flexible polymer components in the coating in suitable proportions. The present invention, further, relates to the use of gastric retention active delivery systems of the invention for the delivery of one or more water soluble active components A to a mammal.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 16, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Andrea Engel, Thomas Gottstein, Melanie Liefke
  • Patent number: 10682309
    Abstract: Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: June 16, 2020
    Assignee: Washington University
    Inventors: Donald L. Elbert, Jacob Roam
  • Patent number: 10675327
    Abstract: Disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of diseases related to melanin. Specifically disclosed are applications of a mussel adhesive protein or preparations thereof in treatment and prevention of pigmentations such as chloasma, freckles, melanosis, applications in skin cancers represented by melanoma, and applications in treatment of pigmentation possibly caused by skin diseases or drugs.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: June 9, 2020
    Assignee: JIANGYIN BENGT I. SAMUELSSON INSTITUTE OF LIFE SCIENCE CO., LTD.
    Inventors: Jan Christer Janson, Min Gao
  • Patent number: 10668097
    Abstract: A composition for the enhancement of free testosterone is provided, the composition comprising: vitamin B6; vitamin B12; zinc; L-citrulline; fenugreek seed extract; an adenosine triphosphate (ATP) stimulating component, comprising: ancient peat extract, and apple fruit extract; eurycoma root extract; and boron. A method of increasing free testosterone is provided, the method comprising administering to an individual an effective dose of a composition comprising: vitamin B6; vitamin B12; zinc; L-citrulline; fenugreek seed extract; an adenosine triphosphate (ATP) stimulating component, comprising: ancient peat extract, and apple fruit extract; eurycoma extract; and boron.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: June 2, 2020
    Assignee: DIRECT DIGITAL, LLC
    Inventor: Natalie Jones
  • Patent number: 10660826
    Abstract: The present invention relates to a solid makeup and/or care cosmetic composition in the form of a compact powder, comprising, in a physiologically acceptable medium, at least: one pulverulent phase, one organopolysiloxane elastomer, one emulsifying system, one hydrophilic gelling agent, and one organic non-volatile oil present in a content of greater than or equal to 1% by weight relative to the total weight of the composition. The invention also relates to an intermediate composition for the preparation of such a cosmetic composition, to a process for manufacturing this cosmetic composition, and to a process for coating the skin with the said cosmetic composition.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: May 26, 2020
    Assignee: L'ORÉAL
    Inventors: Anne Simonnet, Stephane Masson
  • Patent number: 10662258
    Abstract: This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 ?m, but less than 250 ?m; an apparent specific volume of 2 to less than 15 cm3/g; and an organic carbon content from residual impurities, which is defined by the total organic carbon content (%) during 1% NaOH extraction to the total organic carbon content (%) during pure water extraction, of over 0.07 to 0.3%.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: May 26, 2020
    Assignee: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Kazuhiro Obae, Masayuki Kakizawa, Mitsuo Yamashita
  • Patent number: 10653620
    Abstract: A method of preventing or treating an eye condition includes administering a sterile aqueous ophthalmic solution to an eye for the prevention or treatment of dry eye syndrome or dry eye sign and/or dry eye symptom. The sterile aqueous ophthalmic solution includes about 0.05% to about 0.5% (w/w) of N—(N-acetylcysteinyl-)chitosan or a pharmaceutically acceptable salt thereof in a carrier solution, wherein the N—(N-acetylcysteinyl-)chitosan has a content of free thiol groups in an amount of from 80 ?mol/g polymer to 280 ?mol/g polymer.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: May 19, 2020
    Assignee: CROMA-PHARMA GESELLCHAFT M.B.H.
    Inventor: Martin Prinz
  • Patent number: 10653610
    Abstract: The instant disclosure relates to anhydrous hair-treatment compositions. The anhydrous hair-treatment compositions typically include one or more bis-urea derivatives, hydrophobic silica aerogel, and one or more solvents, for example, ester oils and non-ester oil solvents. Additional components such as silicones, etc., can also be included. Kits comprising the hair-treatment compositions and methods of using the hair-treatment compositions are also disclosed.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 19, 2020
    Assignee: L'OREAL
    Inventors: Marie Huynh, Anand Mahadeshwar, Miao Wang, Lisa Chuyin Ye-Tse, Bayle Augustin
  • Patent number: 10653899
    Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: May 19, 2020
    Assignee: SOL-GEL TECHNOLOGIES LTD.
    Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
  • Patent number: 10646438
    Abstract: Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: May 12, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Maria A. Croyle, Jin Huk Choi, Stephen Clay Schafer
  • Patent number: 10638761
    Abstract: Metal free antimicrobial and UV protection additives, which can be used in building or finishing materials, such as plasters, mortars, primers, paints and other protective or decorative coatings to eliminate growth of bacteria, fungi, algae and lichen and to protect material from ultraviolet (UV) radiation. The additive having mixed organophilic layer illite-smectite, chlorite, illite, carbonates, silica and hematite with the following ratio of the components (weight %): mixed layer organophilic illite-smectite from 40 to 70%; chlorite from 5 to 10%; illite from 5 to 10%; carbonates from 0 to 20%; silica from 5 to 20%; hematite from 0 to 3%. The mixed layer illite-smectite is organophilized with quaternary ammonium compounds used in the amount from 10 to 30% counting from the required weight of the mixed layer organophilic illite-smectite.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: May 5, 2020
    Assignee: ALINA, SIA
    Inventors: Juris Kostjukovs, Julija Karasa, Solvita Kostjukova
  • Patent number: 10639276
    Abstract: Among others, the present invention provides a blank liposome, preparation methods thereof, and a loaded liposome including the blank liposome and an active substance. The liposomes have a membrane comprising lipids and a ginsenoside of Formula I, and may further comprise a surfactant, a heat-sensitive excipient, a pH sensitive material, or an ion additive.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: May 5, 2020
    Assignee: Shanghai Ginposome Pharmatech Co., Ltd.
    Inventors: Chong Li, Yahua Wang, Huaxing Zhan
  • Patent number: 10631564
    Abstract: This disclosure provides a microencapsulated capsule or microparticle comprising a nutrient-filled core encapsulated in an enteric coating. The microparticles are useful in the treatment of a variety of disorders when ingested or administered to a subject in need thereof. Alternate non-encapsulated methods and compositions for providing the desired intestinal release are provided included modified nutrient composition and matrix embedded nutrient.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: April 28, 2020
    Assignee: University of Southern California
    Inventors: Elizabeth Demetriades, Travis Williams
  • Patent number: 10632070
    Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: April 28, 2020
    Assignee: The Regents of the University of California
    Inventors: Liangfang Zhang, Che-Ming Jack Hu, Weiwei Gao, Jonathan Coop
  • Patent number: 10626085
    Abstract: The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: April 21, 2020
    Assignee: ImmunoMet Therapeutics Inc.
    Inventors: Hong Woo Kim, Jae Kap Jeong, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Sung Wuk Kim
  • Patent number: 10617619
    Abstract: The present invention relates to a composition comprising one or more quaternary ester ammonium compounds (a), one or more amidoamine compounds (b), wherein the weight ratio between the one or more quaternary ester ammonium compounds (a) and the one or more amidoamine compounds (b) is within a range of 1:5 to 5:1, and one or more fatty alcohols (c). The present invention also relates to a composition that is solid at room temperature, to a hair conditioner composition and to a method to prepare the hair conditioner composition by dispersing the solid composition in water at moderate temperatures.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: April 14, 2020
    Assignee: KAO Corporation S.A.
    Inventors: Pilar Castan Barberan, Judit Rodriguez Costero
  • Patent number: 10610476
    Abstract: The present invention relates to cosmetic compositions comprising a combination of at least one triazine compound of general formula (I): wherein A, B, X and R are as defined in the description, with other cosmetic sunscreens.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: April 7, 2020
    Assignee: 3V Sigma S.P.A.
    Inventors: Francesco Maestri, Ferruccio Berte′
  • Patent number: 10610611
    Abstract: A water-based fragrance composition comprises at least about 67 wt % water and between about 5 and about 17 wt % of a first organic solvent, wherein the first organic solvent comprises one or more relatively volatile, water soluble, low molecular weight organic compound(s) having a boiling point less than about 100° C. The water-based fragrance composition further comprises about 5 wt % or less of at least one fragrance formulation and between about 0 and about 22 wt % of a second organic solvent, wherein the second organic solvent comprises one or more moderately volatile, water soluble organic compound(s) having a boiling point greater than or equal to about 100° C. and less than or equal to about 300° C.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: April 7, 2020
    Assignee: S. C. Johnson & Son, Inc.
    Inventors: Rachel E. Salowitz, Paul A. Clark
  • Patent number: 10610495
    Abstract: Disclosed herein is a formulation for mitigating brain trauma including, in some embodiments, one or more ?-3 fatty acids, one or more curcuminoids, trans-resveratrol, ?-glycerylphosphorylcholine (“?-GPC”), and uridine-5?-monophosphate (“UMP”). The formulation is an oil-based emulsion including the one or more ?-3 fatty acids, the one or more curcuminoids, the trans-resveratrol, the ?-GPC, and the UMP for oral administration. Also disclosed herein is a packaged formulation for mitigating brain trauma including, in some embodiments, a sealed pouch containing a single dose of the oil-based emulsion including the one or more ?-3 fatty acids, the one or more curcuminoids, trans-resveratrol, ?-GPC, and UMP.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: April 7, 2020
    Inventor: Garrett E. Wdowin
  • Patent number: 10610350
    Abstract: An intraocular lens inserter for use during cataract surgery for delivering an intraocular lens (IOL) loaded into an IOL cartridge into a patient's eye. The inserter comprises an outer shell housing containing a hydraulic housing. A hydraulic piston positioned within the hydraulic housing defines an annular hydraulic chamber. The hydraulic chamber is filled with a fluid via a fill port. A high pressure compression spring constantly urges the piston forwardly to pressurize the fluid in the hydraulic chamber. During use, a valve element operatively connected to a depressible operation button, controls bleeding of fluid from the hydraulic chamber, whereupon the forward tip of the piston is moved forwardly to mechanically deliver the intraocular lens from the IOL cartridge into the patient's eye.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: April 7, 2020
    Assignee: Halkey-Roberts Corporation
    Inventors: Avraham Zakay, Raz Ben Yaakov, Jonathan D Collins, Daniel M Swantner, Gregory A Yarbrough
  • Patent number: 10610563
    Abstract: The invention discloses a method of treating, preventing or ameliorating tumor or symptoms resulting from defective neurofibromatosis type-2 gene in a subject by administering to the subject a therapeutically effective amount of a ubiquitin-proteasome system inhibitor which inhibits or slows the growth of neurofibromatosis type-2-deficient tumor or associated symptoms. The invention also includes methods of diagnosis and screening of patients for neurofibromatosis type-2 and mesothelioma.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 7, 2020
    Assignee: BIOXCEL CORPORATION
    Inventors: Krishnan Nandabalan, Sameer Sharma, Luca Rastelli
  • Patent number: 10598665
    Abstract: The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: March 24, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raghu Kalluri, Sónia Melo
  • Patent number: 10596117
    Abstract: The present invention provides a water continuous dispersion of nanoparticles. The water continuous dispersion includes: one or more aromatic amide anesthetic compounds; one or more polyethoxylated high HLB surfactants; one or more low HLB surfactants; one or more oils, wherein one or more nanoparticles of a dispersed phase include a lipid bilayer, and wherein ratio of oil to surfactant is between about 0.12:1 to about 3.5:1. Methods of preparing various water continuous dispersion of nanoparticles are also provided.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: March 24, 2020
    Inventor: Eric Morrison
  • Patent number: 10596079
    Abstract: Disclosed herein are oil-in-water dispersions and sunscreen compositions that contain them, which exhibit high in vivo sun protection factor (SPF) efficiency due to the ability of the dispersions to both absorb and scatter ultraviolet (UV) light. These high efficiency sunscreen compositions include discrete oil particles that are enclosed within a solid coating and dispersed in an aqueous phase, wherein each oil particle contains an organic ultraviolet A (UVA) and/or an organic ultraviolet B (UVB) absorbing compound, and optionally a photo stabilizer.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: March 24, 2020
    Assignee: Deckner Consulting Services, LLC
    Inventors: George Endel Deckner, Nickolas Huss
  • Patent number: 10588863
    Abstract: Extended release pyridostigmine dosage forms, suitable for maintaining stable plasma concentrations with reduced or minimized initial burst release/dose dumping of pyridostigmine, are provided. The dosage forms include matrix tablets, gastroretentive tablets, and pellets, the latter being suitable for dosing in capsules, tablets, and sachets, as well as for sprinkling on foodstuffs. The disclosure also provides methods for improving patient compliance by administering once-a-day extended release pyridostigmine bromide dosage forms that provide a superior controlled drug release.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: March 17, 2020
    Assignee: KASHIV BIOSCIENCES, LLC
    Inventors: Siva Ram Kiran Vaka, Namdev B. Shelke, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah
  • Patent number: 10588943
    Abstract: The present invention relates to the use of liver-selective glucokinase activators and a GLP1 analog in restoring insulin sensitivity and treating type II diabetes, including reducing body weight in subjects undergoing type II diabetes treatment.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 17, 2020
    Assignee: vTv Therapeutics LLC
    Inventors: Maria Carmen Valcarce Lopez, Tung Fong
  • Patent number: 10583151
    Abstract: Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (?-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for treating a cancer in subject with nanobiopolymeric conjugates are described.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 10, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Satoshi Inoue, Hui Ding, Eggehard Holler, Keith L. Black, Julia Y. Ljubimova
  • Patent number: 10576092
    Abstract: This invention relates to molecule and methods of treating diseases and disorders utilizing a Compound: ((3bS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl N-[(2S,3S,6R)-3-hydroxy-2-methyl-6-{[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl]oxy}oxan-4-yl]carbamate) and pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs and polymorphs thereof. The present invention encompasses the in vitro and in vivo use of the said compound and the incorporation of the said compound into pharmaceutical compositions for the treatments and preventions of a variety of diseases and disorders.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: March 3, 2020
    Assignees: S.S. MANUFACTURING CO. LTD.
    Inventor: Ornin Ruangwattanasuk
  • Patent number: 10561640
    Abstract: The present invention relates to a topical preparation for skin tissue protection and reparation. The complex preparation includes the following components: (1) polyethylene glycol; (2) water; and (3) flavonoid compound. The complex preparation may: (1) repair skin injury or promote wound healing; (2) eliminate scars; (3) prevent or treat skin injury caused by radiotherapy; and (4) prevent or treat radiodermatitis.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: February 18, 2020
    Assignee: NANJING JIANZHUANG BIOTECHNOLOGY LIMITED COMPANY
    Inventor: Wei Zeng
  • Patent number: 10563243
    Abstract: Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: February 18, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Lyndsay Schaeffer-Korbylo, Betty Won, Venda Porter Maloney, Gregory Szewczyk
  • Patent number: 10555943
    Abstract: The present invention relates to a solid pharmaceutical composition of temozolomide that has good and consistent flowability as a powder and taste masking and is readily dispersible in an aqueous solution suitable for oral administration, e.g., as a dry sprinkle. This permits patients and healthcare workers to accurately measure doses and safely dispense the drug.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: February 11, 2020
    Assignee: AMPLIPHARM PHARMACEUTICALS, LLC
    Inventors: Gary Payton, Jeff Bryant
  • Patent number: 10555878
    Abstract: The invention relates to a solid composition in the form of a water-in-oil emulsion comprising, in a cosmetically acceptable carrier: (i) at least one discontinuous aqueous phase, (ii) at least one fatty phase comprising at least one particular wax, (iii) at least one silicone emulsifier selected in the group consisting in alkyldimethicone copolyols of particular formula (I) and dimethicone copolyols of particular formula (II) and mixtures there of (iv) and at least one antiperspirant active agent and/or one deodorant active agent. The invention relates to a method for treating body odours associated with human perspiration, and in particular body odours which are especially underarm odours. The invention relates to a method for preparing a solid composition in the form of a water-in-oil emulsion as defined above.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: February 11, 2020
    Assignee: L'OREAL
    Inventors: Cyril Lemoine, Patrick Forhan, Laurence Sebillotte-Arnaud, Xavier Jalenques
  • Patent number: 10549129
    Abstract: A cosmetic composition suitable for topical application is provided. The cosmetic composition comprises: glycerin; a lipid bilayer structurant with a glyceryl headgroup; a penetration enhancer; and a skin care active. The penetration enhancer increases the amount of active that enters skin when the composition is topically applied, while the glycerin and lipid bilayer structurant with glyceryl headgroup work together with lipid bilayers of the skin to impede progress of active through the skin.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: February 4, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Kunal Virendra Gujraty, Shikhar Gupta, Stevan David Jones, Naohisa Yoshimi
  • Patent number: 10543164
    Abstract: A deodorant stick comprising: at least about 25% of a liquid triglyceride; at least one antimicrobial; a primary structurant with a melting point of at least about 50° C.; and less than 8% of secondary structurants having a melting point of at least about 60° C.; said stick being free of an aluminum salt; and said stick having a hardness from about 80 mm*10 to about 140 mm*10, as measured by penetration with ASTM D-1321 needle.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: January 28, 2020
    Assignee: The Procter & Gamble Company
    Inventors: David Arthur Sturgis, Lindsey Michelle Britt
  • Patent number: 10543242
    Abstract: The present invention relates to a composition for improving the health status of various joints in the human body. The composition includes at least one plant extract as fatty base with active role, at least one extract from plants with anti-microbial properties, at least one extract from plants with analgesic and/or anti-inflammatory properties, and at least one extract from plants with anti-rheumatic and regenerative properties, to which dimethylsulfoxide, allantoin and/or potassium alum may be added. The composition may be used to treat osteoarthritis, rheumatic joint disease, joint swelling, pain, hallux valgus, traumatic conditions of the joints including sprains, strains, post-surgical recovery, bone edema, and speed up the recovery of athletes post-injury.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: January 28, 2020
    Inventors: Felician Stancioiu, Daniele Catanas
  • Patent number: 10544086
    Abstract: The disclosure relates to dialkyl carbonates of branched alcohols and their use in cosmetic and/or pharmaceutical compositions. The disclosure more particularly relates to dialkyl carbonates in which the alkyl groups are both 2-propyl-1-heptyl groups.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: January 28, 2020
    Assignee: Cognis IP Management GmbH
    Inventors: Achim Ansmann, Bernd Boutty, Markus Dierker, Stefan Bruening, Rolf Kawa
  • Patent number: 10537528
    Abstract: The disclosure relates, in general, to treatment of fatty liver disorders comprising administering compositions comprising cysteamine or cystamine compositions. The disclosure provides administration of enterically coated cysteamine compositions to treat fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 21, 2020
    Assignee: The Regents of the University of California
    Inventors: Ranjan Dohil, Patrice Rioux
  • Patent number: 10537524
    Abstract: The present invention provided an apixaban solid composition and a preparation method thereof. The method comprises granulating apixaban by wet granulation, wherein the apixaban has a particle size D90 more than 89 ?m.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: January 21, 2020
    Assignee: NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    Inventors: Qibiao Huang, Xin Huang, Fangfang Huang, Jinsong You, Feng Zhao
  • Patent number: 10537518
    Abstract: A viscous composition for transdermal drug delivery, a method of preparing the same, and a microstructure device prepared using the viscous composition are provided. Here, the viscous composition includes colloidal particles formed of a combination of a drug and a biodegradable polymer, and the biodegradable polymer includes a first amphiphilic polymer. The use of a solvent can be minimized to homogenize the drug in the biodegradable polymer including the first amphiphilic polymer, thereby forming colloidal particles. Therefore, since a separate solvent cannot be used, the microstructure device is expected to be a transdermal drug delivery system which is safe, efficient or useful for drugs which do not include a proper solvent, show poor bioavailability or have a high molecular weight.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: January 21, 2020
    Assignee: Juvic Inc.
    Inventors: Hyung Il Jung, Dangol Manita
  • Patent number: 10537453
    Abstract: Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, monitoring, and retrieving the same are provided.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: January 21, 2020
    Assignee: Obalon Therapeutics, Inc.
    Inventors: Mark C. Brister, Betty Wong, Neil R. Drake, Sheldon Nelson, Daniel J. Proctor, Kate Sapp, Eleanor McCarthy
  • Patent number: 10525134
    Abstract: The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly composition comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: January 7, 2020
    Assignee: NeuroDerm, Ltd.
    Inventors: Oron Yacoby-Zeevi, Mara Nemas
  • Patent number: 10525132
    Abstract: The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: January 7, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kana Imamura, Tomohiro Shinoda, Shingo Somekawa, Yasunari Michinaka
  • Patent number: 10517992
    Abstract: The present invention is directed to optical hydrogels, whose shape and/or refractive indices can be catalyzed by the application of light, methods of preparing the same, and optical devices and lenses derived therefrom.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: December 31, 2019
    Assignee: California Institute of Technology
    Inventor: Robert H. Grubbs
  • Patent number: 10512695
    Abstract: The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises inulin.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: December 24, 2019
    Assignee: FERRING B.V.
    Inventors: Varinder Ahuja, Tejas Gunjikar, Kristin Wannerberger
  • Patent number: 10510265
    Abstract: A system and method for predicting a health outcome of a user based on a determination of knowledge the user possesses regarding issues of physiological or mental health.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: December 17, 2019
    Assignee: Hi.Q, Inc.
    Inventors: Shuo Jiao, Munjal Shah, Ardaman Singh
  • Patent number: 10507107
    Abstract: An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element (2) fastened thereto, by means of which the sealing body is able to be fastened in the heart, preferably in the atrium of the heart, wherein the sealing body comprises at least one cavity (6), which is also able to be filled with a fluid after implanting the sealing body and preferably not able to be emptied independently, and wherein, furthermore preferably, the sealing body remains expanded with constant volume during the cardiac phases as a result of the filling, characterized in that a plurality of cavities (6) are disposed about a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, or a single cavity (6) surrounds a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, wherein the main body (1) is embodied as a tube which is able to be bent out of the linear extent thereof and in
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: December 17, 2019
    Assignees: Universität Duisburg-Essen, coramaze technologies GmbH
    Inventors: Niklas Maximilian Nathe, Till Neumann, Torsten Scheuermann
  • Patent number: 10500208
    Abstract: Disclosed herein are novel pharmaceutical formulations of aprepitant suitable for parenteral administration including intravenous administration. Also included are formulations including both aprepitant and dexamethasone sodium phosphate. The pharmaceutical formulations are stable oil-in-water emulsions for non-oral treatment of emesis and are particularly useful for treatment of subjects undergoing highly emetogenic cancer chemotherapy.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: December 10, 2019
    Assignee: HERON THERAPEUTICS, INC.
    Inventors: Thomas B. Ottoboni, Han Han
  • Patent number: 10500222
    Abstract: Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the need for transplantation. Methods of treating bacterial infection of the cornea prophylactically or therapeutically in a subject, are provided according to aspects of the present invention which include administering an effective dose of glycyrrhizin, or a pharmaceutically acceptable salt, hydrate, solvate, ester, amide, isomer or derivative thereof characterized by anti-bacterial activity, to the subject.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: December 10, 2019
    Assignee: Wayne State University
    Inventor: Linda D. Hazlett