Preparations Characterized By Special Physical Form Patents (Class 424/400)
  • Patent number: 11020368
    Abstract: The present invention provides aqueous ophthalmic compositions in the form of solution comprising hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester and macrogol 15 hydroxystearate as the only solubilizing agent, and a method for their preparation.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: June 1, 2021
    Assignee: NICOX S.A.
    Inventors: Frédéric Pilotaz, Alan L. Weiner, Marina Do, Julien Saldo
  • Patent number: 11021687
    Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-? inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: June 1, 2021
    Assignees: The Brigham And Women's Hospital, Inc., Massachusetts Institute Of Technology
    Inventors: Jeffrey Michael Karp, Robert Samuel Langer, Xiaolei Yin
  • Patent number: 11021578
    Abstract: Provided is a production method for a gel composition including steps (1) to (3) mentioned below: step (1) of mixing at room temperature a partial degradation product of the galactose moiety of galactoxyloglucan and an aqueous solvent to obtain a mixture; step (2) of cooling or freezing the mixture obtained in step (1); and step (3) of gelling the mixture cooled or frozen in step (2) by heating to obtain a gel composition that includes the galactose-partial degradation product.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 1, 2021
    Assignee: DSP Gokyo Food & Chemicals Co., Ltd.
    Inventors: Akira Tabuchi, Hiroshi Egawa
  • Patent number: 11013828
    Abstract: The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: May 25, 2021
    Assignee: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James Yoo, In Kap Ko
  • Patent number: 11007276
    Abstract: The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B). In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S- terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 18, 2021
    Assignee: National University Corporation Hokkaido University
    Inventor: Shin-Ichiro Nishimura
  • Patent number: 11007142
    Abstract: The invention relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets that are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: May 18, 2021
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
  • Patent number: 11007147
    Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: May 18, 2021
    Assignee: The Regents of the University of California
    Inventors: Liangfang Zhang, Che-Ming Jack Hu, Weiwei Gao, Jonathan Copp
  • Patent number: 11007244
    Abstract: The present invention relates to pharmaceutical compositions with mucoadhesive and sustained release characteristics containing the association of the extract or fractions of Curcuma longa L. with curcuminoid content greater than 5% and Bidens pilosa (Bd) extract, which has an important proliferative and anti-inflammatory effect, for the treatment of inflammatory diseases of the oral cavity (stomatitis) and of the gastrointestinal tract, as, for example, mucositis induced by radiotherapy and/or chemotherapy and aphthous lesions. Additionally, inflammatory skin lesions and vaginal mucositis. These are compositions obtained from a liquid base formulation containing an aqueous-based solvent system. The subject of the present invention is, therefore, to obtain pharmaceutical preparations, to develop their obtainment processes and to establish their uses.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: May 18, 2021
    Assignees: FBM INDUSTRIA FARMACÊUTICA LTDA., UNIVERSIDADE FEDERAL DE GOIAS
    Inventors: Marize Campos Valadares Bozinis, Eliana Martins Lima, Aline Carvalho Batista, Ricardo Neves Maretto, Elisamauro Francisco de Mendonça
  • Patent number: 11007207
    Abstract: Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 18, 2021
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Bei Cheng, Huacheng He
  • Patent number: 11000575
    Abstract: The present invention relates to the use of hyaluronidase for the prevention and/or treatment of cardiac insufficiency. In addition, the present invention provides a composition and a combined preparation each comprising hyaluronidase and at least one further antihypertensive, and a method of prevention and/or treating cardiac insufficiency in a patient in need thereof, wherein the patient is administered a therapeutically effective amount of hyaluronidase.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: May 11, 2021
    Assignee: Pantarhin Pharma LLC
    Inventors: Dieter Cullmann, Gunther Burgard
  • Patent number: 10993892
    Abstract: The present invention relates to an anhydrous composition in aerosol form comprising, in particular in a physiologically acceptable medium: a) an oily phase comprising i) at least one volatile oil, and ii) at least one nonvolatile hydrocarbon-based oil, and iii) at least one phenyl silicone, and b) at least one antiperspirant active agent chosen from aluminum and/or zirconium salts or complexes, c) at least one water-insoluble film-forming block ethylenic polymer d) at least one propellant. The invention also relates to a cosmetic process for treating human perspiration, and optionally the body odors associated with human perspiration, especially underarm odors, comprising the application of said composition to a surface of the skin.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: May 4, 2021
    Assignee: L'OREAL
    Inventors: Veronique Ferrari, Laure Ramos-Stanbury, Xavier Jalenques
  • Patent number: 10987391
    Abstract: A method for combining energy supplements such as energy drinks or food items with Cannabis extract. The energy supplements include at least one energizing active ingredient of variable potency. The Cannabis extract may be produced of variable potency from at least one strain of Cannabis. The agglomerated product may be produced in various forms of food or beverages. When used, the agglomerated product may provide the typical effects of Cannabis in addition to the added energy and focus provided by energy supplements.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: April 27, 2021
    Inventor: Slate Podaima
  • Patent number: 10987423
    Abstract: The present system is directed in several embodiments to a method of administration of a therapeutic composition for protection of the brain of a subject at risk of injury leading to traumatic brain injury (TBI) and/or treatment of injury to the brain resulting from TBI. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patient's CNS, with no to minimal systemic exposure. Preferably, this method comprises administration of an effective amount of insulin to the upper third of a patient's nasal cavity, thereby bypassing the patient's blood-brain barrier and delivering the therapeutic composition directly to the patient's central nervous system.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: April 27, 2021
    Assignees: HealthPartners Research & Education, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: William H. Frey, II, Leah Ranae Bresin Hanson, Kimberly Byrnes, Fiona Brabazon
  • Patent number: 10987364
    Abstract: Described herein are synthetic progestogens, such as 6?,7?:15?,16?-Dimethylene-3-oxo-17?-pregn-4-ene-21,17-carbolactone, as well as pharmaceutical compositions comprising the same. Also described are methods of use.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: April 27, 2021
    Assignee: LABORATORIOS LEON FARMA SA
    Inventors: Philippe Perrin, José Luis Velada, Dominique Drouin
  • Patent number: 10988755
    Abstract: A method for extracting nucleic acids from a biological sample by isolating nucleic acid-containing particles from the biological sample by one or more centrifugation procedures, performing one or more steps to mitigate adverse factors that prevent or might prevent high quality nucleic acid extraction, and extracting nucleic acids from the isolated particles. The centrifugation procedures are performed at a speed not exceeding about 200,000 g. The extracted nucleic acids contain both 18S and 28S rRNA.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 27, 2021
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Leileata M. Russo
  • Patent number: 10982396
    Abstract: A slip form paver machine includes a slip form mold and left and right side form assemblies closing the slip form mold on the sides. Each side form assembly includes a mounting portion, a side form, and a side form actuator configured to move the side form up and down relative to the mounting portion to adjust a height of the side form relative to the ground surface. At least one side form height sensor is configured to detect the height of the side form. A controller is configured to receive input signals from the side form height sensors and to send control signals to the side form actuators to control the height of the side forms relative to the ground surface.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: April 20, 2021
    Inventor: Matthias Fritz
  • Patent number: 10980844
    Abstract: In one embodiment, a composition may include beeswax, Candelilla wax, oregano oil, glycerin, olive oil, arnica plant concentrate, and carbolic acid. In another embodiment, a method for treating an injury to an affected limb may include may include cleaning the affected limb, providing a water-based treatment composition, applying the water-based treatment composition to the affected limb, providing an oil-based treatment composition, and applying the oil-based treatment composition to the affected limb. The method may further include providing a gauze impregnated with a wax-based treatment composition and wrapping the impregnated gauze around the affected limb. The water-based treatment composition may include water, essence of oregano, and carbolic acid. The oil-based treatment composition may include glycerin, arnica plant concentrate, and carbolic acid. The wax-based treatment composition may include beeswax, Candelilla wax, arnica plant concentrate, and carbolic acid.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: April 20, 2021
    Assignee: XOsmar Industries, LLC
    Inventor: Humberto Ignacio Campillo Ronquillo
  • Patent number: 10978396
    Abstract: A composite element and methods of fabrication thereof are provided. The composite element can include a binder material and one or more electrical traces supported by the binder material, where a composition of the binder material is a thermoresponsive material and where each of the one or more electrical traces comprises an interconnected network of nanoparticles.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: April 13, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Leon Bellan, Xin Zhang
  • Patent number: 10973954
    Abstract: The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: April 13, 2021
    Assignee: MASSACHUSETTS EYE AND EAR INFIRMARY
    Inventors: James Anthony Stefater, III, Tomasz Pawel Stryjewski
  • Patent number: 10975247
    Abstract: A non-porous composite is provided that includes a textile substrate impregnated with a first fluoropolymer and a film of polymeric material comprising at least one second fluoropolymer filled with porous particles of a silicate having a granulometric dimension d50 less than or equal to 5 ?m and a porosity ranging from 30 to 60% in volume and loaded with antibacterial ions of at least one metal selected from the group consisting of silver, copper, zinc and nickel. A method for production of the composite and a containing and/or transport element for a fluid, preferably water, produced with the composite, are also provided.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: April 13, 2021
    Assignees: Guarniflon S.p.A., Arcari, Srl, Thales Alenia Space Italia S.p.A. Con Unico Socio
    Inventors: Ilaria Locantore, Vincenzo Guarnieri, Cesare Lobascio, Emanuele Colombo, Massimo Villano, Giacomo Simoni, Lucia Grizzaffi
  • Patent number: 10973955
    Abstract: The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: April 13, 2021
    Assignee: MASSACHUSETTS EYE AND EAR INFIRMARY
    Inventors: James Anthony Stefater, III, Tomasz Pawel Stryjewski
  • Patent number: 10973947
    Abstract: A mixture of honey solution and a surgical adhesive, typically a cyanoacrylate adhesive is described. The adhesive and honey solution are mixed and applied to a cut or wound prior to the cure of the mixture. The adhesive mixture, which retains the strength of the unadulterated adhesive significantly reduces the growth of bacteria in the vicinity of the associated closed cut or wound, has applicability in both human and veterinary medicine.
    Type: Grant
    Filed: February 11, 2018
    Date of Patent: April 13, 2021
    Inventor: Peyton M Leyendecker
  • Patent number: 10966951
    Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject having reduced kidney function.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: April 6, 2021
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventor: Sephy Philip
  • Patent number: 10966915
    Abstract: A deodorant stick comprising: at least about 25% of a liquid triglyceride; at least one antimicrobial; a primary structurant with a melting point of at least about 50° C.; and less than 8% of secondary structurants having a melting point of at least about 60° C.; said stick being free of an aluminum salt; and said stick having a hardness from about 80 mm*10 to about 140 mm*10, as measured by penetration with ASTM D-1321 needle.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: April 6, 2021
    Assignee: The Procter & Gamble Company
    Inventors: David Arthur Sturgis, Lindsey Michelle Britt
  • Patent number: 10959940
    Abstract: An anti-allergenic composition comprising from about 0.01% to about 50% by weight of a polyphenol, from about 0.01% to about 50% by weight of a terpene compound, and from about 0.001% to about 10% by weight of a glycolipid. The polyphenol has a flavanol derivative. The terpene compound can be selected from the group consisting of a terpene, terpinene, a terpene derivative and combinations thereof. In an embodiment, the sphingolipid comprises about 0.2% phytosphingosine.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 30, 2021
    Assignee: OCuSOFT INC.
    Inventors: Nat Adkins, Jr., Troy Smith, Paramita Sarkar
  • Patent number: 10961323
    Abstract: Provided is a method for producing HPMCP capable of reducing the average particle size of HPMCP particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose phthalate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose phthalate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose phthalate, thereby obtaining a hypromellose phthalate suspension, a liquid removal step of removing a liquid from the hypromellose phthalate suspension with a centrifugal decanter to obtain liquid-removed hypromellose phthalate, and a drying step of drying the liquid-removed hypromellose phthalate.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: March 30, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Mitsuhiro Yoshida, Junichi Matsubara
  • Patent number: 10960078
    Abstract: The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: March 30, 2021
    Assignee: Shanghai Jiao Tong University
    Inventors: Deyue Yan, Ping Huang, Xinyuan Zhu, Wei Huang, Yongfeng Zhou
  • Patent number: 10945961
    Abstract: Among other things, compositions, kits, and methods for epilepsy therapy using a process for treating calcinosis manifested in Neurocysticercosis, Tuberous Sclerosis Complex, and Sturge-Weber Syndrome; an automated platform for real-time diagnosis and treatment of calcinosis comprising a computer-implemented method for using predictive analytics for administering a novel drug, Kamini™, to human patients generated at least in part from information that has been accumulated automatically from on-line resources.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 16, 2021
    Assignee: ZY YTHERAPEUTICS LLC
    Inventors: Bryan Alan Hill, John Stephan McCarty, Jeffrey Arlin Loeb
  • Patent number: 10945941
    Abstract: Hair treatment agents are provided herein. The hair treatment agent contains at least one fatty alcohol; at least one cationic surfactant; at least one divalent or trivalent metal salt; at least one silver salt selected from silver acetate, silver adipate, silver citrate, silver galactarate, silver gluconate, silver lactate, silver malate, silver mandelate, silver salicylate, silver succinate, silver sulfate, and silver tartrate; and at least one organic acid selected from adipic acid, succinic acid, citric acid, acetic acid, galactaric acid, gluconic acid, hydroxysuccinic acid, mandelic acid, lactic acid, salicylic acid, sulfuric acid, and tartaric acid. The hair treatment agent reduces or prevents the fading of color from dyed hair.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: March 16, 2021
    Assignee: Henkel AG & Co. KGaA
    Inventors: Volker Scheunemann, Erik Schulze zur Wiesche, Rene Krohn
  • Patent number: 10940103
    Abstract: The instant disclosure relates to masks, methods for making masks, methods for improving film elasticity of masks, and to methods of treating skin with masks. The masks are formed by applying a mask base composition onto a surface, the mask base composition comprising: (i) alginic acid and/or a salt thereof; (ii) hectorite (lithium magnesium sodium silicate); (iii) one or more water-soluble solvents; and (iv) water; and exposing the mask base composition to a crosslinking composition for a time sufficient to crosslink the alginic acid and/or a salt thereof and form a final mask, the crosslinking composition being an aqueous liquid comprising (i) one or more polyvalent cations of one or more metals; and (ii) water. The instant disclosure further relates to masks formed by the disclosed methods and to kits comprising the compositions for making and/or using the masks.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 9, 2021
    Assignee: L'OREAL
    Inventors: Jonathan Faig, David Chan
  • Patent number: 10933047
    Abstract: Disclosed herein are improved formulations for the cabazitaxel. The formulations exhibit increased storage stability relative to other formulations, and are simpler for health care providers to prepare and administer to patients.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: March 2, 2021
    Assignee: Cipla Limited
    Inventors: Geena Malhotra, Sarabjit Singh, Ravichandra Bhadravathi Vedamurthy, Anirban Mallik Thakur, Dhiraj Abhyankar
  • Patent number: 10918597
    Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: February 16, 2021
    Assignee: KASHIV SPECIALTY PHARMACEUTICALS, LLC
    Inventors: Kanji Meghpara, Harpreet Kaur Sandhu, Ashish Chatterji, Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Jaydeep Vaghashiya
  • Patent number: 10920248
    Abstract: The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 16, 2021
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Cha Young Kim, Yu Jeong Jeong, Suk Weon Kim, Mun Chual Rho, Young Bae Ryu, Woo Song Lee, Jae Cheol Jeong
  • Patent number: 10919867
    Abstract: Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstituted benzotriazole phenol by coupling reactions. The ortho substituent group can be a simple alkoxy or amino group, or the ortho substituent group can be a linking group, linking the benzotriazole phenol to another benzotriazole phenol group.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: February 16, 2021
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Kelly A. Volp, Nathan E. Schultz, Fuming B. Li
  • Patent number: 10912759
    Abstract: Methods of treating a methicillin-resistant Staphylococcus aureus (MRSA) infection or a Staphylococcus pseudintermedius infection in subject in need thereof are provided, the methods comprising administering to the subject an effective amount of a topical gel composition comprising vitamin E d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS); and at least one lipophile. Compositions, methods of manufacture, and methods of use in inhibiting microbial growth are also provided.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: February 9, 2021
    Inventor: William Andrew Clark
  • Patent number: 10912866
    Abstract: A porous bionic skull repairing material includes a polymer material, whose structure is consistent with that of a human skull. The surface layers of the porous bionic skull repairing material are dense layers which are composed of non-degradable or degradable polymer materials and has blind holes having an asymmetric structure, and the inner layer of the porous bionic skull repairing material is a loose layer which has a porous structure. The repairing material can be molded by adopting a mixed mould pressing method or a 3D printing method, simulates a bone structure, with two dense sides and a loose middle, of a human skull to the greatest extent.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 9, 2021
    Assignee: Shandong Branden Medical Device Co., Ltd
    Inventors: Haijun Zhang, Liming Liu, Shoutao Lu, Wenrui Cao, Hairong Xu, Chao Zhou, Yuxia Yin, Wenbo Hou, Cuihai Duan, Guang Liu
  • Patent number: 10905647
    Abstract: A deodorant stick comprising at least 25% by weight liquid triglyceride; a primary antimicrobial having a water solubility of at most about 90 g/L at 25° C.; a fragrance composition comprising at least about 50% natural oils, essential oils, or a combination thereof; and a primary structurant with a melting point of at least 50° C.; said deodorant stick being free of an aluminum salt; and said deodorant stick having a hardness from about 70 mm*10 to about 140 mm*10, as measured by penetration with ASTM D-1321 needle.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: February 2, 2021
    Assignee: The Procter & Gamble Company
    Inventors: David Arthur Sturgis, Lindsey Michelle Britt
  • Patent number: 10907132
    Abstract: A method for growing polarized endometrial cells, said method comprising: (a) disposing endometrial cells on a scaffold, said scaffold comprising a silica-based glass composition, characterized by multi-modal porosity, said scaffold being to define a top side and a bottom side; (b) providing nutrients to said top and bottom sides of said scaffold and an environment to grow polarized endometrial cells on said scaffold.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: February 2, 2021
    Assignee: Lehigh University
    Inventors: Larry Barmat, Matthias Falk, Himanshu Jain, Stephen Somkuti
  • Patent number: 10905711
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: February 2, 2021
    Assignee: Vifor (International) Ltd.
    Inventors: Michael J. Cope, Paul Mansky, Futian Liu, Han-Ting Chang, Dominique Charmot, Eric Connor, Kalpesh Biyani, Mingjun Liu, Tony Kwok-Kong Mong, Yan Chen
  • Patent number: 10898447
    Abstract: This invention relates to medical science and pharmaceutical technology. A new type of finished pharmaceutical form with individual medicine dosing capability is described comprising a storage container and a carrier on which the medicine is applied. Methods of production and use of the finished pharmaceutical form for individual medicine dosing are suggested.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: January 26, 2021
    Assignee: Psirrros Inc.
    Inventors: Sergey Emilevich Kondakov, Aleksandr Pavlovich Osipov, Mikhail Yakovlevich Melnikov, Dmitry Mikhailovich Mikhailov, Maxim Yurievich Mitrohin, Sergey Olegovich Belezkii, Vladimir Vladimirovich Gordeev
  • Patent number: 10894072
    Abstract: Embodiments of the invention generally relate to supplements for treating fibromyalgia and symptoms associated with fibromyalgia, wherein the nutritional supplement is administered for at least one of following: fatigue, chronic pain, morning stiffness, headaches, and problems with thinking and memory.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: January 19, 2021
    Assignee: IP Quality Holdings, LLC
    Inventors: Amy L. Heaton, Dennis Gay
  • Patent number: 10888525
    Abstract: There are provided HPMCAS (hypromellose acetate succinate) having such a property that a solution of the HPMCAS in a solvent has a controlled viscosity; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having such property that a solution of 10 parts by weight of the HPMCAS in 100 parts by weight of a mixed solvent having a weight ratio of methylene chloride to methanol of 1:1 has a viscosity at 20° C. of 135 mPa·s or less; and a method for producing the HPMCAS including an esterification step of adding acetic anhydride and succinic anhydride to a solution of hypromellose in glacial acetic acid in the presence of sodium acetate to obtain a reaction product mixture, wherein the succinic anhydride is added intermittently, and a precipitation step of mixing the reaction product mixture with water to precipitate the HPMCAS.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: January 12, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Junichi Matsubara, Naosuke Maruyama, Mitsuhiro Yoshida
  • Patent number: 10881595
    Abstract: The present disclosure relates to an antiperspirant composition for a roll-on application comprising a) at least one antiperspirant active substance including an inorganic or organic salt of aluminum, zirconium or a mixture thereof, b) a rice starch and c) a hydrophobically modified clay mineral. Furthermore, the present disclosure relates to a roll-on applicator including a composition as contemplated herein, and a non-therapeutic use of a composition as contemplated herein.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: January 5, 2021
    Assignee: Henkel AG & Co. KGaA
    Inventor: Thomas Doering
  • Patent number: 10881617
    Abstract: Extended release pyridostigmine dosage forms, suitable for maintaining stable plasma concentrations with reduced or minimized initial burst release/dose dumping of pyridostigmine, are provided. The dosage forms include matrix tablets, gastroretentive tablets, and pellets, the latter being suitable for dosing in capsules, tablets, and sachets, as well as for sprinkling on foodstuffs. The disclosure also provides methods for improving patient compliance by administering once-a-day extended release pyridostigmine bromide dosage forms that provide a superior controlled drug release.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: January 5, 2021
    Assignee: KASHIV BIOSCIENCES, LLC
    Inventors: Siva Ram Kiran Vaka, Namdev B. Shelke, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah
  • Patent number: 10881634
    Abstract: The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: January 5, 2021
    Assignee: HUGHES BIOTECHNOLOGY CO., LTD
    Inventors: Shang-Ta Wang, Chen Hsu, Nan-Wei Su
  • Patent number: 10881760
    Abstract: A cryogel which includes lignin nanoparticles embedded in crosslinked gelatin. The cryogel is formed at subfreezing temperatures where aggregation of polymerized or crosslinked materials is prevented by ice crystals. When thawed, the cryogel is a densely crosslinked microporous composition with a plurality of pores ranging from 50-150 ?m in size. The cryogel combines a natural bio waste polymer in the form of lignin together with a collagen derived natural polymer. Incorporation of lignin within gelatin improves the mechanical performance of the cryogel and enhances its shape recovery rate. The macropororous composition inhibits growth of both gram positive and gram negative bacteria. In addition, the macoporous composition exhibits excellent free radical scavenging activity. All of the properties make the cryogel an excellent material for wound healing and tissue engineering applications.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: January 5, 2021
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Adnan Memic, Tuerdimaimaiti Abudula
  • Patent number: 10875893
    Abstract: In some aspects, the present invention provides compositions and methods of treatment comprising long-acting compstatin analogs. In some aspects, long-acting compstatin analogs comprise a clearance-reducing moiety attached to two compstatin analog moieties, wherein each compstatin analog moiety comprises a cyclic peptide comprising the amino acid sequence as set forth in SEQ ID NO: 28 extended by a lysine residue or a sequence comprising a lysine residue at the N-terminus, C-terminus, or both, wherein the lysine residue is separated from the cyclic portion of the peptide by a spacer comprising 8-amino-3,6-dioxaoctanoic acid (AEEAc) moiety, the clearance reducing moiety comprises a polymer, wherein each end of the polymer is linked to one of the compstatin analog moieties by way of a linker moiety that is or comprises a carbamate, and wherein the polymer is a PEG having an average molecular weight of about 40 kDa.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: December 29, 2020
    Assignee: Apellis Pharmaceuticals, Inc.
    Inventors: Cedric Francois, Pascal Deschatelets
  • Patent number: 10864148
    Abstract: The present invention relates to a composition and method for stabilisation of compounds including retinoids using the synergistic effects of beta-carotene and sodium polyaspartate.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: December 15, 2020
    Assignee: Pangaea Laboratories Ltd.
    Inventors: Daniel Isaacs, Elliot Isaacs, Kavitha Murugesan
  • Patent number: 10858483
    Abstract: Polyphosphazenes polyelectrolytes. The polyphosphazenes can be prepared by substituting pendant groups (e.g., ionic groups or pendant groups that can form ionic groups) onto a reactive macromolecular precursor for example, by reaction between the reactive chlorine atoms on the backbone of poly(dichlorophosphazene) and appropriate organic nucleophiles. In certain examples, one or more charged pendant groups of a polyphosphazene is/are further modified to introduce desired counterions, which can be hydrophobic counterions. The polyphosphazenes can activate distinct Toll-Like Receptors (TLRs) and can be used in methods of stimulating an immune response.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: December 8, 2020
    Assignee: University of Maryland, College Park
    Inventors: Alexander K. Andrianov, Thomas R. Fuerst, Peter Fusco, Alexander Marin
  • Patent number: 10850011
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: December 1, 2020
    Assignee: Board of Regents, The University of Texas
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes