Liposomes Patents (Class 424/450)
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Patent number: 9849087Abstract: Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.Type: GrantFiled: November 8, 2012Date of Patent: December 26, 2017Assignee: The Board of Trustees of the University of ArkansasInventors: Daniel Fologea, Ralph Henry, Greg Salamo, Yuriy Mazur, Michael J. Borrelli
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Patent number: 9849186Abstract: Provided is a triblock copolymer represented by General Formula (I): CNR-PEG-CNR??(1) or a polycation thereof, wherein each CNR is independently a polymer segment having a repeating unit containing as part of a pendant group a cyclic nitroxide radical that binds to the polymer main chain via a linking group having at least one imino group or ether bond, and PEG is a segment containing poly(ethylene glycol).Type: GrantFiled: January 24, 2013Date of Patent: December 26, 2017Assignee: UNIVERSITY OF TSUKUBAInventors: Yukio Nagasaki, Min Ley Pua, Pennapa Chonpathompikunlert, Toru Yoshitomi
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Patent number: 9844548Abstract: Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.Type: GrantFiled: November 28, 2016Date of Patent: December 19, 2017Assignee: ARADIGM CORPORATIONInventors: Igor Gonda, James Blanchard, David C. Cipolla
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Patent number: 9844656Abstract: A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source.Type: GrantFiled: March 1, 2011Date of Patent: December 19, 2017Assignee: The Regents of the University of CaliforniaInventors: Katherine W. Ferrara, Azedah Kheirolomoom
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Patent number: 9844557Abstract: Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with pharmaceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.Type: GrantFiled: September 19, 2016Date of Patent: December 19, 2017Assignees: WESTERN UNIVERSITY OF HEALTH SCIENCES, TESORX PHARMA, LLCInventors: Guru V. Betageri, Ramachandran Thirucote, Veeran Gowda Kadajji
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Patent number: 9839589Abstract: Disclosed is an apparatus and methods for its use that is configured to be used to treat various skin conditions. The apparatus includes a water-permeable absorbent material and a plant material comprising a water-soluble skin-active ingredient. The plant material is enclosed within the water-permeable absorbent material, and the water-permeable absorbent material is configured to absorb water and allow the absorbed water to contact the plant material so as to release the active ingredient from the plant material. The active ingredient is then absorbed by the absorbent material, which is then topically applied to skin in need of skin treatment.Type: GrantFiled: December 16, 2014Date of Patent: December 12, 2017Assignee: Mary Kay Inc.Inventors: Daniel Chen, James Swanzy
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Patent number: 9839633Abstract: There is provided pharmaceutical compositions for the treatment of rhinitis by, for example, nasal or ocular administration comprising zwitterionic cetirizine, a polar lipid liposome and a pharmaceutical acceptable aqueous carrier. The compositions are preferably homogeneous in their nature.Type: GrantFiled: April 11, 2012Date of Patent: December 12, 2017Assignee: Biolipox ABInventors: Lena Pereswetoff-Morath, Anders Carlsson
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Patent number: 9827266Abstract: The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location with acne, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.Type: GrantFiled: February 11, 2016Date of Patent: November 28, 2017Assignee: Transdermal Biotechnology, Inc.Inventor: Nicholas V. Perricone
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Patent number: 9827337Abstract: The invention relates to Cathepsin-binding compounds bound to a carrier comprising a diagnostic moiety, for use in the diagnosis of inflammatory diseases, and/or for use in the diagnosis of neoplastic diseases, wherein the Cathepsin-binding compound binds to inflammatory cells of the tumour stroma. The invention also relates to Cathepsin B-targeting compounds and Cathepsin B-binding and liposome-binding compounds.Type: GrantFiled: June 22, 2012Date of Patent: November 28, 2017Assignee: J. Stefan InstituteInventors: Olga Vasiljeva, Georgy Mikhaylov, Boris Turk, Norbert Schaschke
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Patent number: 9820941Abstract: The present invention provides a composition comprising a sPLA2 hydrolysable liposome, an exterior solution, and an interior solution within the liposome, —wherein the concentration of osmolytes is higher in the interior solution than in the exterior solution. The composition improves storage stability of sPLA2 hydrolysable liposomes, in particular at when stored at 2-8 degrees Celsius. The liposome preferably encapsulates cisplatin. The invention also provides methods of preparing the composition of the invention.Type: GrantFiled: October 25, 2010Date of Patent: November 21, 2017Assignee: Bio-Bedst ApSInventors: Mogens Winkel Madsen, Sune Allan Petersen, Anders Falk Vikbjerg
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Patent number: 9821077Abstract: The present invention relates to the provision of nanoparticular formulations comprising a PEG-alkyl block copolymer and a near infrared fluorescent dye, the preparation of these nanoparticular formulations, pharmaceutical compositions comprising the nanoparticular formulations of the present invention, as well as their use as contrast medium.Type: GrantFiled: September 12, 2008Date of Patent: November 21, 2017Assignee: NANOPET PHARMA GMBHInventor: Malte Bahner
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Patent number: 9821051Abstract: Compared to an unadjuvanted vaccine, an adjuvanted influenza vaccine can reduce by almost a quarter the risk of hospitalization for respiratory illness (e.g. influenza and pneumonia) in elderly recipients. Thus the invention provides a method for immunizing an elderly subject by administering an adjuvanted influenza vaccine, whereby the subject's risk of hospitalization for respiratory illness (e.g. influenza and pneumonia) is reduced relative to an elderly subject who receives an unadjuvanted influenza vaccine.Type: GrantFiled: October 21, 2011Date of Patent: November 21, 2017Assignee: Seqirus UK LimitedInventor: Nicola Groth
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Patent number: 9821035Abstract: The purpose of the present invention is to provide a preparation for preventing or treating type I diabetes, said preparation exerting an excellent effect of preventing or treating type I diabetes, and a method for preventing or treating type I diabetes. The onset and symptoms of type I diabetes can be very remarkably relieved by dosing a combination of: (A) at least one member selected from the group consisting of proinsulin, insulin, insulin A chain, insulin B chain, fragments thereof and variants thereof; with (B) ?-GalCer.Type: GrantFiled: August 22, 2013Date of Patent: November 21, 2017Assignee: REGIMMUNE CORPORATIONInventors: Omar Duramad, Hidetoshi Akimoto, Yasuyuki Ishii, Haruhiko Morita
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Patent number: 9822170Abstract: Epidermal growth factor receptor (EGFR) expression and phosphorylation is increased in cancer cells treated with anti-clusterin antibodies. Such treatment is also accompanied with the reappearance of an epithelial phenotype of the cancer cell, as determined by an increased E-cadherin expression at the surface of cancer cells. Clusterin inhibitors may thus induce reversal of the epithelial to mesenchymal phenotype and restore sensitivity of cancer cells to EGFR inhibitors. Combinations of a clusterin inhibitor and an EGFR as well as their use in treatment of cancer are thus provided herewith.Type: GrantFiled: February 22, 2013Date of Patent: November 21, 2017Assignee: Alethia Biotherapeutics Inc.Inventors: Gilles Bernard Tremblay, Elisabeth Viau, Mario Filion
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Patent number: 9814777Abstract: The present invention provides targeting lipids of structure L100-linker-L101??(CI), where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or —CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.Type: GrantFiled: October 22, 2013Date of Patent: November 14, 2017Assignee: Arbutus Biopharma CorporationInventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Jayaprakash K. Nair, Muthusamy Jayaraman
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Patent number: 9808534Abstract: This invention is directed to the use of a chorionic gonadotrophin carboxy terminal peptide (CTP) or fragments thereof for modifying a polypeptide or a fragment thereof in order to increase the hydrodynamic volume of the polypeptide or fragment thereof.Type: GrantFiled: November 20, 2013Date of Patent: November 7, 2017Assignee: OPKO Biologics Ltd.Inventors: Oren Hershkovitz, Ahuva Bar-Ilan
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Patent number: 9801934Abstract: The present invention relates to single dose parenteral vaccine compositions comprising mixtures of monovalent Norovirus virus-like particles. Methods of conferring protective immunity against Norovirus infections in a human subject by administering such compositions are also disclosed.Type: GrantFiled: March 15, 2013Date of Patent: October 31, 2017Assignee: TAKEDA VACCINES, INC.Inventors: Charles Richardson, Thomas R. Foubert
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Patent number: 9803060Abstract: Compositions and methods for preparing at least partially hollow nanoparticles having an outer shell comprising a one or more molecules and/or residues derived from a metal soap, where the nanoparticles each comprise a continuous inner void space that averages at least 10 percent of the volume of each of the nanoparticles. Such at least partially hollow nanoparticles can be employed in a variety of applications including, but not limited to, tire manufacturing.Type: GrantFiled: October 4, 2010Date of Patent: October 31, 2017Assignee: Bridgestone CorporationInventors: Xiaorong Wang, Mindaugas Rackaitis, Pat Sadhukhan, Victor J. Foltz
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Patent number: 9804152Abstract: Provided are methods and systems for determining functional relationships between ex vivo skin models and an inflammatory skin condition. Also provided are methods and systems for identifying modulators of inflammation of skin, as well as the use of modulators identified by such methods or systems for the preparation of cosmetic compositions, personal care products, or both.Type: GrantFiled: August 15, 2013Date of Patent: October 31, 2017Assignee: The Procter & Gamble CompanyInventors: Deborah Ruth Finlay, Kevin John Mills, Charles Carson Bascom
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Patent number: 9801818Abstract: A method for stabilizing a poorly water-soluble drug-containing amphiphilic block copolymer micelle composition via simplified steps in short time is described. Also described is a stabilized poorly water-soluble drug-containing amphiphilic block copolymer micelle composition having improved stability.Type: GrantFiled: August 6, 2013Date of Patent: October 31, 2017Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Sa-Won Lee, Min-Hyo Seo
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Patent number: 9795621Abstract: Methods and materials for reducing organ transplant rejection or minimizing ischemia or ischemia/reperfusion injury in a subject are described. The methods include administering a fat emulsion before or after the organ transplant or before, at the onset of, or after the ischemic event.Type: GrantFiled: September 6, 2013Date of Patent: October 24, 2017Assignee: Carnegie Mellon UniversityInventors: Chien Ho, Li Liu, Yijen Wu, T. Kevin Hitchens, Qing Ye
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Patent number: 9789129Abstract: Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.Type: GrantFiled: April 14, 2009Date of Patent: October 17, 2017Assignee: PDS Biotechnology CorporationInventors: Elizabeth Ann Vasievich, Weihsu Claire Chen, Kenya Toney Johnson, Gregory Conn, Frank Bedu-Addo, Leaf Huang
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Patent number: 9790491Abstract: A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including a single-stranded or double-stranded polynucleotide containing the base sequence shown in SEQ ID NO:41 or a base sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 41, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided.Type: GrantFiled: June 28, 2011Date of Patent: October 17, 2017Assignee: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITYInventor: Norimasa Miura
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Patent number: 9789127Abstract: Pharmaceutical, cosmetic and dietetic compositions and functional foods, constituted by: A) phospholipid mixtures containing N-acyl-phosphatidyl-ethanolamines (NAPEs) and/or B) phospholipid mixtures containing N-acyl-ethanol amines (NAEs) together with phosphatidic acids (PAs) and/or lysophosphatidic acids (LPAs) with the proviso that said N-acyl-phosphatidyl-ethanolamines (NAPEs) do not include N-oleoyl-phosphatidyl-ethanolamine. New phosphobioflavonic complexes of NAPE or NAE with one or more bioflavonoids are also disclosed.Type: GrantFiled: September 19, 2007Date of Patent: October 17, 2017Assignee: HUNZA DI PISTOLESI ELVIRA & C. S.A.S.Inventors: Elvira Pistolesi, Benvenuto Cestaro
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Patent number: 9782385Abstract: An artificial tears solution combination is composed mainly of an anti-inflammation and anti-oxidation material, a liquid viscosity-enhancing agent, and an artificial tears solution. The artificial tears solution combination is capable keeping moisture, and meanwhile having anti-inflammation and anti-oxidation capabilities. As such, it can prolong the liquid retention on ocular surfaces, to effective reduce the repeated dosing, and shorten the schedule for the dry eye syndrome.Type: GrantFiled: April 29, 2016Date of Patent: October 10, 2017Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Feng-Huei Lin, Hsu-Wei Fang, Ching-Li Tseng, Ya-Jung Hung
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Patent number: 9782343Abstract: The embodiments herein provide a nano-carrier system for delivering a long-acting injectable drug of morphine and a method of synthesising the same. The morphine entrapped nanoparticles are prepared using a lipid/phospholipid core which is coated by a polymer. The lipid and phospholipid are dissolved in organic solvent. This solution is transferred into an aqueous phase consisting of distilled water or a buffer. A solution of polymer is added drop wise. The drug entrapped nanoparticle formation is achieved by diffusion of the organic solvent within the aqueous solvent to obtain the nanoparticles. The drug gets entrapped within the nanoparticles via the anti-solvency effect of the aqueous matrix. The resulting drug nanocarriers are capable of releasing the drug in a slow rate upon injection. The synthesized drug carrying nanoparticles are cryopreserved stored for future administration. For better storage, the nanodispersion is dried to form a powder.Type: GrantFiled: July 21, 2014Date of Patent: October 10, 2017Inventor: Mehrdad Hamidi
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Patent number: 9775797Abstract: The present invention relates to a personal care composition for topical application having skin lightening application. It is an object of the present invention to provide for a personal care composition that comprises fractions obtained from natural sources that gives enhanced skin lightening as compared to known fractions from natural sources.Type: GrantFiled: March 11, 2013Date of Patent: October 3, 2017Assignee: Conopco, Inc.Inventors: Vijay Ramchandra Gadgil, Praful Gulab Rao Lahorkar
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Patent number: 9775804Abstract: The specification relates to an internal structured self assembled liposome (ISSAL), containing a nuclear core molecule or complex including a first affinity enhancing molecule; and a phospholipid-affinity enhancing complex having a phospholipid coupled to second affinity enhancing molecule, wherein the second affinity enhancing molecule couples to the first affinity enhancing molecule. The ISSAL's can be used in, for example and without limitation, the field of drug delivery, vaccination, imaging contrast agents, and nanotechnology, in which liposomes of ordered, self-assembling structure are employed to deliver soluble or insoluble molecules to any sub-cellular address.Type: GrantFiled: August 14, 2013Date of Patent: October 3, 2017Inventor: Aaron Froese
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Patent number: 9770415Abstract: An aligned polymer article including substrates, wherein the substrates are not covalently bonded to the aligned collagen and a method of forming such articles wherein substrates are mixed with a polymer in solution to form a polymer-substrate mixture. The mixture is placed in an electrochemical cell and a voltage is applied to the cell generating a pH gradient, wherein the polymer aligns in the cell and migrates to the isoelectric plane of the polymer solution.Type: GrantFiled: November 8, 2013Date of Patent: September 26, 2017Assignee: SOUTHWEST RESEARCH INSTITUTEInventor: Xingguo Cheng
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Patent number: 9763939Abstract: The invention described herein relates to methods for treating mitochondrial diseases. In particular, the invention relates to methods for treating mitochondrial diseases by administering therapeutically effective amounts of one or more tetracyclic pyrazinoindoles, and/or pharmaceutically acceptable salts thereof.Type: GrantFiled: October 28, 2015Date of Patent: September 19, 2017Assignee: BIOVISTA, INC.Inventors: Spyros Deftereos, Andreas Persidis
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Patent number: 9763965Abstract: The present invention relates to aggregate particles comprising nanoparticulate drug particles. In particular, the present invention is directed to aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide and optionally vilanterol trifenatate and/or fluticasone furoate. Aggregate particles of the present invention may further comprise nanoparticulate excipient particles and one or more binders. The invention also relates to powder compositions suitable for inhalation that comprise said aggregate particles, processes of producing said aggregate particles, and use of said powder compositions in the treatment of respiratory diseases, such as asthma and COPD.Type: GrantFiled: April 11, 2013Date of Patent: September 19, 2017Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Michiel Mary Van Oort, John N. Hong
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Patent number: 9763881Abstract: The present invention relates to a formulation in which glycolipids and phospholipids, isolated from rice bran gum samples, were used in conjunction with gene carrying lipids to test its efficacy in delivering genes to cancer cells selectively. This formulation did not mediate efficient delivery of genes to non-cancerous cells, thus, showing potential use of this formulation to deliver anticancer therapeutics to cancer cells without eliciting treatment related toxicity to normal cells.Type: GrantFiled: June 11, 2013Date of Patent: September 19, 2017Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Sayantani Roy, Rajkumar Banerjee, Pradosh Prasad Chakrabarti, Badari Narayana Prasad Rachapudi
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Prevention and treatment of alzheimer's disease by amyloid beta peptide and sphin-gosine-1-phosphate
Patent number: 9757398Abstract: The invention provides compositions and methods for treatment of Alzheimer's disease. Such methods entail administering agents that induce a beneficial immune and therapeutic response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In certain preferred embodiments of such methods, a preferred agent is amyloid beta peptide in combination with Sphingosine-1-phosphate, preferably delivered in certain embodiments in a liposomal formulation.Type: GrantFiled: February 18, 2011Date of Patent: September 12, 2017Assignee: EUROESPES BIOTECNNOLOGIA, S.L.Inventors: Carmen Vigo, Ramon Cacabelos -
Patent number: 9757336Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: GrantFiled: March 6, 2013Date of Patent: September 12, 2017Assignee: Pacira Pharmaceuticals, Inc.Inventors: Ernest George Schutt, Ronald Warren McGuire, Peter Andrew Walters, Kathleen D. A. Los
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Patent number: 9758795Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.Type: GrantFiled: May 4, 2012Date of Patent: September 12, 2017Assignee: The University of British ColumbiaInventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft, James Taylor, Andre Wild, Stuart Malcolm, Ismail Hafez, Alex Leung, David Walker
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Patent number: 9757462Abstract: The invention relates to a combined pharmaceutical composition or pharmaceutical preparation, comprising a first component containing a first ligand for a polyspecific lectin in a reticuloendothelial cell and a second component containing a carrier, a labeling agent, or a medicament for treating a disease associated with a target cell, each of which is targeted by a second ligand for a polyspecific lectin in a reticuloendothelial cell different from the first ligand, and also relates to a method for labeling a target cell and a method for treating a disease associated with a target cell, each using the same.Type: GrantFiled: October 20, 2011Date of Patent: September 12, 2017Assignee: Sapporo Medical UniversityInventors: Junji Kato, Rishu Takimoto
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Patent number: 9757344Abstract: A coated fine particle comprisisng: (i) a complex of a drug and a cationic lipid, wherein (a) the drug is a nucleic acid and the complex is obtained by mixing the drug and the cationic lipid in water, wherein the complex has a diameter of 10 nm to 1,000 nm, and (ii) a lipid layer formed of lipid(s), wherein the lipid(s) is selected from phospholipid, glyceroglycolipid, sphingoglycolipid, cholesterol and synthetic lipid, wherein the complex is coated with the lipid layer.Type: GrantFiled: February 1, 2010Date of Patent: September 12, 2017Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Yasuki Kato, Masahiro Yamauchi, Hiroko Kusano, Takeshi Iwata, Takaaki Uochi, Shiro Akinaga
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Patent number: 9750821Abstract: Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.Type: GrantFiled: December 21, 2004Date of Patent: September 5, 2017Assignee: Bracco Suisse S.A.Inventors: Michel Schneider, Philippe Bussat, Feng Yan, Anne Senente
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Patent number: 9750718Abstract: The present invention is directed to compositions and associated methods for treatment, prevention, amelioration, and/or delaying the onset of hepatic fibrosis and/or associated diseases. The methods preferably involve regulating at least one of Rev-erb? expression, activity, and subcellular localization. In particular, certain embodiments of the present invention relate to compositions and methods of using a Rev-erb-modulating agent (REMA) for the treatment or prevention of hepatic fibrosis and/or associated diseases. Preferably, the amount of a REMA administered comprises a quantity sufficient to modulate at least one of Rev-erb? expression, activity, and subcellular localization and reduce the activation of hepatic stellate cells (HSCs).Type: GrantFiled: December 12, 2013Date of Patent: September 5, 2017Assignee: The Charlotte-Mecklenburg Hospital AuthorityInventors: Ting Li, Laura Schrum
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Patent number: 9750694Abstract: An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration. By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.Type: GrantFiled: December 17, 2013Date of Patent: September 5, 2017Assignees: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hirofumi Takeuchi, Koji Nakano, Hidekazu Toyobuku
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Patent number: 9750812Abstract: The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least one lipid component for the treatment of skin or eye related diseases.Type: GrantFiled: September 25, 2009Date of Patent: September 5, 2017Assignee: JINA PHARMACEUTICALS, INC.Inventors: Shoukath M. Ali, Ateeq Ahmad, Moghis U. Ahmad, Saifuddin Sheikh, Imran Ahmad
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Patent number: 9744187Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.Type: GrantFiled: October 14, 2016Date of Patent: August 29, 2017Assignee: BIO-PATH HOLDINGS, INC.Inventor: Peter Nielsen
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Patent number: 9744156Abstract: Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.Type: GrantFiled: August 15, 2016Date of Patent: August 29, 2017Assignee: ARNO THERAPEUTICS, INC.Inventors: Sathyanarayana Narasimha Murthy, Stefan Proniuk
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Patent number: 9737480Abstract: The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated micro vesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein.Type: GrantFiled: February 6, 2013Date of Patent: August 22, 2017Assignees: President and Fellows of Harvard College, The Board of Trustees of the Leland Standford Junior UniversityInventors: Quan Lu, Joseph F. Nabhan, Stanley N. Cohen
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Patent number: 9737484Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.Type: GrantFiled: November 12, 2014Date of Patent: August 22, 2017Assignee: Marina Biotech, Inc.Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
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Patent number: 9737555Abstract: Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.Type: GrantFiled: July 24, 2015Date of Patent: August 22, 2017Assignee: INSMED INCORPORATEDInventor: Renu Gupta
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Patent number: 9732324Abstract: The invention provides a method of reducing viral infectivity in a sample comprising contacting the sample with a earner matrix wherein lipids are attached to the carrier matrix, and wherein at least one virus-specific agent is attached to the lipids The virus-specific agent is capable of binding to at least one viral component The virus specific agent may be a receptor The earner matrix may be a silica particle, which may be coated with a lipid bilayer The invention further provides a method of inactivating a virus comprising contacting the virus with a earner matrix wherein lipids are attached to the earner matrix, and wherein at least one receptor is attached to the lipids, binding the receptor to at least one viral receptor-binding protein, and activating at least one viral fusion protein, wherein activation inactivates the virus, and releases the virus from the earner matrix.Type: GrantFiled: October 23, 2009Date of Patent: August 15, 2017Assignee: Cornell UniversityInventors: Anne Moscona, Matteo Porotto, David Alexander LaVan, Feng Yi
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Patent number: 9731264Abstract: A method and an apparatus for preparing aerogel by drying under reduced pressure. The gel to be dried is placed into a sealed drying apparatus which can be depressurized by air extraction or/and can be heated to raise the temperature. The methods of reducing pressure by air extraction or/and raising temperature are acted upon the water and solvents within the aerogel to be dried, and an outward force is thus generated for the water and solvents to be volatilized outwards. By controlling the rates of reducing pressure by air extraction or/and raising temperature, the outward force is allowed to be equal to or close to the inward capillary force, such that the pores of the gel may not be collapsed or cracked. At the same time, drying is carried out continuously, and finally the interior water and solvents are removed completely.Type: GrantFiled: May 6, 2014Date of Patent: August 15, 2017Assignee: HONG DA TECHNOLOGY (BEI JING) CO. LTD.Inventor: Guangwu Li
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Patent number: 9724301Abstract: Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.Type: GrantFiled: July 24, 2015Date of Patent: August 8, 2017Assignee: INSMED INCORPORATEDInventor: Renu Gupta
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Patent number: 9724366Abstract: A conditioned medium of CD11blow macrophages and methods for preparing it are provided. Pharmaceutical compositions comprising the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages and their use in the treatment of cancer or fibrosis are also provided.Type: GrantFiled: December 30, 2013Date of Patent: August 8, 2017Assignee: Carmel-Haifa University Economic Corporation LtdInventors: Dalit Barkan, Odelya Gilon, Amiram Ariel, Sagie Schif-Zuck, Aroesti-Assi Simaan