Gelatin Patents (Class 424/456)
  • Patent number: 10449070
    Abstract: The present invention relates to a nanoparticle composition which is prepared by a process which is characterized by dissolving a poorly water-soluble compound or the like under a high temperature and a high pressure, and milling a suspension or the like containing a uniform crystal obtained by cooling the obtained solution.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: October 22, 2019
    Assignees: Kinki University, OTSUKA PHARMACEUTICAL CO., LTD.
    Inventor: Yoshimasa Ito
  • Patent number: 10363254
    Abstract: Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: July 30, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher D. Huston, Kovi Bessoff, Rajiv Satish Jumani
  • Patent number: 10245273
    Abstract: Pharmaceutical products comprising a hypolipidemic agent and a testosterone ester such as testosterone undecanoate are provided. Methods of safely treating a testosterone deficiency or its symptoms with the inventive pharmaceutical products are also provided.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: April 2, 2019
    Assignee: Clarus Therapeutics, Inc.
    Inventors: Wael Salameh, Panayiotis Constantinides
  • Patent number: 10212957
    Abstract: Disclosed in the present invention is a method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts): mixing 100 parts of carotenoid microcapsule, 100-400 parts of vegetable oil and 0.1-1 part of oil-soluble antioxidant; and grinding the mixture in a colloid mill in a nitro—gen atmosphere and at 10-30° C. to obtain a uniform oil-dispersible carotenoid preparation, wherein the preparation contains 2%-14% carotenoid with an average particle size of up to 0.1-1 ?m, and 100 parts of carotenoid microcapsule contains 10.5-35.8 parts carotenoid, 0.1-1 part of water-soluble antioxidant, and the remainder is a water-soluble colloid. The advantages of the present invention lie in that the oil-dispersible form has a high stability as the surface of the carotenoid particles is still protected with a dense water-soluble colloid, and that an oil-dispersible carotenoid preparation containing carotenoid with a content of up to 2%-14% and an average particle size of only 0.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: February 26, 2019
    Assignees: ZHEJIANG UNIVERSITY, ZHEJIANG NHU COMPANY LTD.
    Inventors: Dan Qiu, Lifang Shi, Jiandong Li, Zhirong Chen, Jiachao Zhou
  • Patent number: 10206971
    Abstract: Disclosed herein are methods of formulating cyclosporin A Form 2.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: February 19, 2019
    Assignee: Allergan, Inc.
    Inventors: Anuradha V. Gore, Prem Swaroop Mohanty, E. Quinn Farnes
  • Patent number: 10072311
    Abstract: The invention relates to novel Lactobacillus strains isolated from sourdough. Also encompassed is a composition comprising at least one of said Lactobacillus strains with optionally additional other microorganisms such as bacteria and/or yeasts. The invention further relates to the use of said Lactobacillus strains or compositions for the manufacture of human food products and food supplement products or animal feed products. Another aspect of the invention is the use of the Lactobacillus strains or the composition of Lactobacillus strains in human or veterinary medicine or in cosmetics.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: September 11, 2018
    Assignee: Ludwig Stocker Hofpfisterei GmbH
    Inventor: Jürgen Mayer
  • Patent number: 9993560
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: June 12, 2018
    Assignee: CIPLA Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 9982264
    Abstract: The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against SMAD7. The pharmaceutical formulations can be used to treat Crohn's disease, ulcerative colitis and chronic inflammatory bowel disease.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 29, 2018
    Assignee: Nogra Pharma Limited
    Inventors: Sergio Baroni, Salvatore Bellinvia, Francesca Viti
  • Patent number: 9949916
    Abstract: A non-irritating personal lubricant composition comprises a silicone fluid carrier and at least one sensorial agent, the composition having a viscosity of at least 175 centistokes.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: April 24, 2018
    Assignee: Church & Dwight Co., Inc.
    Inventors: Ovidiu Romanoschi, Jason R. Kieke, Michael J. Harrison, Luis Muniz
  • Patent number: 9938485
    Abstract: Compositions for increasing corn oil recovery and embodiments of methods for using the composition for corn oil separation are described. The composition(s) incorporate an admixture that includes a polymer selected from a polyglycol ester, a polyethyleneoxide-polypropyleneoxide block copolymer, a poloxamine, or a mixture thereof. The methods include admixing the compositions with a process stream for, for example, the extraction of oil from milled corn and residues from a fermentation step, including stillage (e.g., thin stillage or mid stillage), distiller's wet grain, distiller's dry grain and distiller's dry grains with solubles.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: April 10, 2018
    Assignees: Polymer Venture Inc., Phibro Animal Health Co.
    Inventors: Christopher B. Murphy, David A Fowlie
  • Patent number: 9925138
    Abstract: The present invention relates to a solid pharmaceutical dosage forms and methods for preparing the solid pharmaceutical dosage form that contains fingolimod or its pharmaceutically acceptable salts, conjugates or complexes thereof. The solid pharmaceutical dosage forms may rapidly disintegrates in a patient's oral cavity.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: March 27, 2018
    Assignee: Handa Pharmaceuticals, LLC
    Inventor: Fangyu Liu
  • Patent number: 9907789
    Abstract: Provided is a sustained-release preparation containing pioglitazone or a salt thereof as an active ingredient and showing superior sustainability. A sustained-release preparation containing pioglitazone or a salt thereof, which shows a dissolution ratio of pioglitazone of average 25-58% at the 2-hour time point, and average 60-100% at the 4-hour time point, in a dissolution test according to the 50 rpm USP Paddle Method and using pH 2.0 KCl/HCl buffer at 37° C. as a test solution.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: March 6, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Yutaka Tanoue, Yusuke Murakawa, Yumiko Ishii, Kaoru Takenaka
  • Patent number: 9889152
    Abstract: Herein provided are dosage forms (variously referred to as “formulations”) comprising a PPI that is released from the dosage form as a first and a second dose. Each dose of PPI is present in an amount sufficient to raise the plasma levels of the PPI to at least 100 ng/ml.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: February 13, 2018
    Assignee: Takeda Pharmaceuticals U.S.A., Inc.
    Inventors: Rajneesh Taneja, Majid Vakilynejad
  • Patent number: 9795617
    Abstract: A hormone delivery system and method are provided for administering bioidentical human hormones using a combination of modalities for the treatment of human physiological conditions.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: October 24, 2017
    Assignee: Baucom Institute for Longevity and Life Enhancement, Inc.
    Inventor: Karan Y. Baucom
  • Patent number: 9775814
    Abstract: Described herein are enteric soft capsules comprising gastric resistant polymers and gelatin and methods for manufacturing the same. The enteric soft capsules described herein have enhanced enteric and elastic properties and are simpler to manufacture and produce.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: October 3, 2017
    Assignee: PATHEON SOFTGELS INC.
    Inventors: Helena Maria de Albuquerque Ferreira Teles, Henricus Marinus Gerardus Maria van Duijnhoven, Mélanie Françoise Géraldine Bayarri
  • Patent number: 9744182
    Abstract: Described herein are manufactured dietary supplements that contain a phospholipid extract, folic acid, vitamin D, vitamin B6, vitamin B12, Vitamin E, Vitamin C, iodine, iron, and magnesium. Described herein are manufactured dietary supplements that contain a phospholipid extract that contain phospholipid-DHA.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: August 29, 2017
    Assignee: Buriva, LLC.
    Inventors: Rhett Sean Daniels, Brett B Bartel
  • Patent number: 9730885
    Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: August 15, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
  • Patent number: 9717678
    Abstract: A delivery system for administration to a patient of Fenobam, its hydrates, and salts optimizes solubility and dissolution properties of Fenobam, its hydrates, and salts using either microemulsions, solid dispersions, cyclodextrin, gastroretentives, enteric coatings, and sustained delivery techniques to provide a vehicle for oral administration of these drugs.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: August 1, 2017
    Assignee: MURTY PHARMACEUTICALS, INC.
    Inventors: Santos B Murty, Ram B Murty
  • Patent number: 9661844
    Abstract: Vehicles for delivery and release of pesticide compositions are provided. In one aspect, the delivery vehicle is a capsule configured to resist release of a pesticide composition before application of the capsule at a locus where pest control is desired. The capsule is further configured to degrade following application at the locus where pest control is desired to facilitate release of the pesticide composition. In one particular but non-limiting form, the capsule includes a shell wall including a relatively high Bloom strength gelatin material and a plasticizer material, and the pesticide composition includes a fumigant such as 1,3-dichloropropene. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: May 30, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Lorenzo Aulisa, John D. Busacca, Donald E. Williams, III, Phillip J. Howard, Ashish Batra, Sara J. Linder
  • Patent number: 9592200
    Abstract: An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: March 14, 2017
    Assignee: COLLEGIUM PHARMACEUTICAL, INC.
    Inventors: Roman V. Rariy, Alison B. Fleming, Jane Hirsh, Alexander M. Klibanov
  • Patent number: 9579227
    Abstract: An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, is provided for weight control. The implement includes: a fluid-permeable expandable container having a first dimension and a second dimension; and a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid; whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: February 28, 2017
    Assignee: EAT LITTLE INC.
    Inventors: Martin Mintchev, Orly Yadid-Pecht, Michel Fattouche
  • Patent number: 9579383
    Abstract: A composition is described having improved oral permeability of polar agents such as neuraminidase inhibitors. The composition includes one or more polar agents and one or more permeability enhancers such that the composition increases the amount of the polar agent capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 Cell membrane in the absence of the permeability enhancer. Oral dosage forms including the composition, and methods of treating or preventing influenza infection are also provided.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: February 28, 2017
    Assignee: ALA WAI PHARMA, INC.
    Inventors: Eric Holmes, Michael Hite
  • Patent number: 9522109
    Abstract: A method for enhancing skin collagen in an individual includes administering a composition to the individual, the composition comprising a skin collagen enhancing agent comprising menaquinone-7 as an active ingredient. In addition, a composition is provided in the form of at least one of an emulsion and a cream, the composition including a skin collagen enhancing agent comprising menaquinone-7 as an active ingredient.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: December 20, 2016
    Assignee: J-Oil Mills, Inc.
    Inventors: Toshiro Sato, Rumi Kawahara, Shuichi Kamo
  • Patent number: 9452150
    Abstract: A composition in which a preparation of the composition itself has an excellent disintegratability in the right place and excellent active ingredient releasability within the digestive tract, the active ingredient and the preparation itself have long-term stability, excellent ease of operation such as manufacturability and filling into containers, an amount sufficient for achieving physiological effects can be easily taken and swallowed, and can be absorbed rapidly from the digestive tract, thus the physiological effect can be expected. The composition is an easy-release jelly composition containing an emulsified polyvalent unsaturated fatty acid or derivative thereof in an amount exceedingly 10 mass % and further containing an emulsifying agent and a gallant. The easy-release jelly composition includes an emulsified polyunsaturated fatty acid or derivative thereof in an amount greater than 10 wt %, an emulsifying agent, and a gelling agent.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: September 27, 2016
    Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroki Ueshima, Shigeharu Suzuki, Naomi Yokomizo, Atsushi Sato, Hirosato Fujii
  • Patent number: 9439851
    Abstract: The present invention provides a novel gastric retention system in the form of a tablet or a capsule coated with an expandable coating, more particularly, with an expandable coating comprising a film-forming polymer and an expandable component.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: September 13, 2016
    Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
    Inventors: Nitin Bhalachandra Dharmadhkari, Yashoraj Rupsinh Zala
  • Patent number: 9427012
    Abstract: A softgel capsule containing microencapsulated probiotic bacteria is manufactured such that the softgel capsule is stable for at least about 24 months at room temperature.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: August 30, 2016
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Claudia Valla, Rosa Bertolami, Giovanni Rosina, Karen Helson
  • Patent number: 9408417
    Abstract: A method and a system for preparing a tobacco extract for use in an electronic smoking device are provided. A tobacco extract and an electronic smoking device are also provided. The method includes grinding tobacco into granulated particles, and heating purified water. The method further includes injecting the heated purified water through the granulated particles of the tobacco for a predetermined period of time to produce an aqueous solution, and adding purified water to the aqueous solution. Further, the method includes heating the aqueous solution, and injecting the heated aqueous solution through ground tobacco for the predetermined period of time to produce a tobacco extract for use in the electronic smoking device.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: August 9, 2016
    Assignee: HZAT LLC
    Inventor: Thomas O'Connell
  • Patent number: 9408803
    Abstract: An object of the invention is to provide compositions containing lignan-class compounds as dissolved at high concentrations. The compositions having lignan-class compounds such as sesamin and episesamin dissolved in solvent oils or fats that contain triglycerides of middle-chain fatty acids having 8-12 carbon atoms, preferably triglycerides of caprylic acid and/or capric acid and/or lauric acid can contain the lignan-class compounds stably at higher concentrations than when other solvents are used and, hence, have high enough value as foods and pharmaceuticals.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: August 9, 2016
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventors: Masaaki Nakai, Yukihiro Aoshima, Shuji Endo
  • Patent number: 9339060
    Abstract: A smoking device includes a recipient or able to receive burning products, preferably tobacco, and a filter element connected to the recipient, wherein the filter includes at least one breakable capsule, the capsule having a initial crush strength from 0.5 to 2.5 kp, and keeping a crush strength from 0.5 to 2.5 kp and a deformation of less than two third of its diameter prior to rupture after having been submitted to a smoking test. The invention is also relating to the capsule suitable for being incorporated in a smoking device, and to the process of manufacture of the capsule.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 17, 2016
    Assignee: V. MANE FILS
    Inventors: Didier Hartmann, Jean-Michel Hannetel, Nathalie Coursieres, Jean Mane
  • Patent number: 9339529
    Abstract: Injectable insulin loaded microgels that are capable of modifying the amount of insulin released based on the patient's tissue glucose levels, methods for making and using these compositions have been developed. The microgels contain insulin, glucose oxidase entrapped in or bound to the microgels, and an agent that reduces hydrogen peroxide, entrapped in or bound to the microgels, wherein the polymeric microgel expands when pH decreases from physiological pH and shrinks when pH increases towards physiological pH, thereby releasing insulin at a rate corresponding to the glucose concentration. In one embodiment, the glucose oxidase and/or the agent reducing hydrogen peroxide are encapsulated in nanogels, then encapsulated within the microgel.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: May 17, 2016
    Assignees: Massachusetts Institute of Technology, The Children's Medical Center Corporation
    Inventors: Daniel G. Anderson, Zhen Gu, Robert S. Langer
  • Patent number: 9314465
    Abstract: The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a coughing condition with such compositions.
    Type: Grant
    Filed: May 24, 2014
    Date of Patent: April 19, 2016
    Assignee: Infirst Healthcare Limited
    Inventors: John Brew, Robin Mark Bannister
  • Patent number: 9295658
    Abstract: An orally administered fatty acid composition for the treatment of cardiovascular diseases, and a method of treating same, are provided. The compound includes 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic ethanolamide (EPA ethanolamide), 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic ethanolamide (DHA ethanolamide), and at least one tocotrienol. The EPA ethanolamide and the DHA ethanolamide are preferably each substantially in a range of 100-900 mg per dosage form. The at least one tocotrienol is substantially in a range of 10-500 mg per dosage form. The at least one tocotrienol includes at least one of ?-tocotrienol, ?-tocotrienol, ?-tocotrienol, or ?-tocotrienol and is preferably substantially tocopherol-free. The composition may take the form of a medical food or a pharmaceutical preparation. A preferred formulation of the composition includes approximately 525 mg EPA ethanolamide, approximately 315 mg DHA ethanolamide, and approximately 50 mg ?-tocotrienol.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 29, 2016
    Inventor: Steven C. Quay
  • Patent number: 9289369
    Abstract: A oral care composition includes: (a) a hydrophilic film-forming polymer; and (b) a hydrophobic carrier, wherein the hydrophilic film-forming polymer is a film-forming polymer effective to occlude dentinal tubules and the oral care composition contains 0-10 wt. % water. The hydrophilic film-forming polymer is preferably GANTREZ S. The hydrophobic carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the oral care composition such that the hydrophilic film-forming polymer occludes dentinal tubules. A toothbrush includes: a handle; a head mounted to the handle, the head comprising an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and a gelatin capsule containing the oral care composition positioned on the head.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: March 22, 2016
    Assignee: Colgate-Palmolive Company
    Inventors: Thomas James Boyd, Suman Kumar Chopra, Sarita Vera Mello, Rahul Patel, Dennis Kembero Ontumi
  • Patent number: 9254270
    Abstract: A gel mass is provided that is useful in manufacturing enteric soft or hard capsules, or enteric tablets without coating.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: February 9, 2016
    Assignee: Banner Life Sciences LLC
    Inventors: EmadEldin M. Hassan, Aqeel A. Fatmi, Nachiapan Chidambaram
  • Patent number: 9248139
    Abstract: A process for the production of a formulation of HIV attachment inhibitor piperazine tris salt prodrug compound involves dissolving the prodrug compound in a solvent to form a solution; adding a first quantity of a first anti-solvent to the solution; then dispersing a first quantity of HPMC in the solution; adding a second quantity of the first anti-solvent to the solution; dispersing a second quantity of HPMC in the solution; then adding a second anti-solvent to the solution so as to crystallize the compound with the HPMC and thereby form the formulation, wherein the second anti-solvent is a combination of acetone and isopropyl acetate (IPAC). The formulation is then washed, and dried.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: February 2, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shih-Ying Chang, Donald Kientzler, Deniz Erdemir, San Kiang, Tamar Rosenbaum
  • Patent number: 9192582
    Abstract: Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet®) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: November 24, 2015
    Assignee: Banner Life Sciences LLC
    Inventor: Nachiappan Chidambaram
  • Patent number: 9173948
    Abstract: The present invention relates to a pharmaceutical composition comprising fingolimod and a weak acid cation exchange resin in the form of an ion-exchange complex and pharmaceutically acceptable excipients.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: November 3, 2015
    Assignee: Sun Pharamaceutical Industries, LTD.
    Inventors: Sunil Jaiswal, Krishna Sharma, Nitin Bhalachandra Dharmadhikari, Shirish Kulkarni
  • Patent number: 9168310
    Abstract: The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: October 27, 2015
    Assignee: ENZYMOTEC LTD.
    Inventors: Gai Ben Dror, Dorit Platt, Orly Farkash, Rassan Zuabi, Zohar Bar-On, Avidor Shulman, Dori Pelled, Yael Richter
  • Patent number: 9096815
    Abstract: The present disclosure provides a process for producing 20-carbon fatty acids from a plant seed oil, the process comprising: a) providing a plant seed oil comprising fatty acids, wherein the fatty acids include 18-carbon fatty acids; and b) elongating the fatty acids by two carbon atoms to produce a composition comprising 20-carbon fatty acids.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: August 4, 2015
    Assignee: Dignity Sciences Limited
    Inventors: Mehar Manku, Jonathan Rowe, John Climax
  • Patent number: 9072677
    Abstract: A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 7, 2015
    Assignee: Banner Life Sciences LLC
    Inventors: EmadEldin M. Hassan, Warren Walter Kindt, Roger E. Gordon
  • Publication number: 20150140088
    Abstract: The present invention relates to the fields of chemistry and pharmacy and, in particular, to the production of novel molecular entities: esterane derivatives fused with spirostanes rings, acting upon the Central Nervous Systems (CNS). From diosgenin, a naturally occurring sapogenin, with some subsequent transformations thereof, spirosteroid derivatives of the I-IV general formula can be obtained, with a cyclopentaneperhydrophenantrene nucleus fused to a 25R-spirostanes nucleus. Such molecular entities have an anti-inflammatory and anti-glutamatergic actions that can be used to treat inflammatory, cerebrovascular, neurodegenerative, neuropsychiatric, and neurologic diseases.
    Type: Application
    Filed: December 27, 2012
    Publication date: May 21, 2015
    Inventors: Laura Garcia Pupo, Yanier Nuñez Figueredo, Juan Enrique Tacoronte Morales, Yamila Verdecia Reyes, Estael Ochoa Rodriguez, Zaldo Castro Armando
  • Publication number: 20150118298
    Abstract: Described herein are pharmaceutical compositions comprising polyunsaturated fatty acids and methods of manufacturing the same. In particular, described herein are pharmaceutical compositions comprising soft enteric capsules comprising omega-3 polyunsaturated fatty acids. The oral pharmaceutical compositions described herein are useful as nutritional supplements or for the treatment of cardiovascular-related diseases, such as hyper dyslipidemia and high triglyceride levels.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: Peijin Zhang, Aqeel A. Fatmi
  • Publication number: 20150118297
    Abstract: The invention provides methods and pharmaceutical compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and pharmaceutical compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a pharmaceutical composition comprising a prebiotic, optionally in combination with effective amount of a probiotic microbe or microbes.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 30, 2015
    Applicant: RITTER PHARMACEUTICALS, INC.
    Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer
  • Patent number: 9011908
    Abstract: Fill materials for hydrophobic drugs, such as progesterone, and methods of making and using thereof are described herein. The fill material contains the hydrophobic drug dissolved in one or more fatty acids. The concentration of the hydrophobic drug is typically from about 7% to about 50% by weight of the fill material. The concentration of the one or more fatty acids is from about 60% to about 95% by weight of the carrier. The formulation also contains an organic acid and one or both of one or more pharmaceutically acceptable alcohols and one or more pharmaceutically acceptable mono-, di-, or triesters of medium or long chain fatty acids. The fill material can be encapsulated in a hard or soft capsule. The formulations described herein have a higher dissolution rate and faster onset of dissolution compared to micronized progesterone suspended in an oil and thus should have increased bioavailability in vivo.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: April 21, 2015
    Assignee: Banner Life Sciences LLC
    Inventors: Zhi Liu, Saujanya L. Gosangari, Dana S. Toops, Aqeel Fatmi
  • Patent number: 9011907
    Abstract: The present invention relates to a pharmaceutical or nutraceutical preparation comprising a) a core containing a pharmaceutically or nutraceutically active substance and a substance that acts in a modulatory manner with regard of the release of pharmaceutically or nutraceutically active substances; and b) a controlling layer surrounding the core comprising i) 55 to 92% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate copolymers composed of 80 to 98% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from C1 to C4 alkyl esters of (meth)acrylic acid and 2 to 20% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from (meth)acrylate monomers with a quaternary ammonium group in the alkyl radical; and ii) 8 to 45% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate co
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: April 21, 2015
    Assignee: Evonik Röhm GmbH
    Inventors: Hema Ravishankar, Shradda Bodinge, Hans-Ulrich Petereit
  • Patent number: 9011909
    Abstract: A composition for vaginal insertion is in the form of a softgel, a two-part gelatin capsule, a tablet, or a suppository. The composition is designed to promote the growth of native vaginal flora, but does not promote the growth of Gardenerella vaginalis and Candida albicans. The composition includes a prebiotic in a pharmaceutically acceptable excipient and is essentially free of probiotics, lactoferrin, and plant extracts containing isoflavones.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: April 21, 2015
    Assignee: Wisconsin Pharmacal Company, LLC
    Inventors: JoEllen Currie, Jean M. Young, John Wundrock
  • Publication number: 20150104505
    Abstract: Pharmaceutical compositions in unit dose form comprising a hard or soft capsule containing a fill consisting of one or more inert ingredients, and one or more coatings on the capsule, wherein at least one coating comprises at least one active pharmaceutical ingredient.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 16, 2015
    Inventors: Manish S. SHAH, Ray J. DiFalco
  • Patent number: 8992982
    Abstract: The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way of said medicaments.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: March 31, 2015
    Assignee: Iceutica Pty Ltd.
    Inventors: Aaron Dodd, Felix Meiser, Marck Norret, Adrian Russell, H. William Bosch
  • Publication number: 20150086625
    Abstract: Activated fatty acids, nutraceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: December 8, 2014
    Publication date: March 26, 2015
    Inventor: Raymond A. Miller
  • Patent number: RE47316
    Abstract: This invention relates to a liquid or semisolid oral drug formulation comprising a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: March 26, 2019
    Assignee: QUATRX PHARMACEUTICALS COMPANY
    Inventors: Veli-Matti Lehtola, Markku Anttila