Gelatin Patents (Class 424/456)
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Publication number: 20100303902Abstract: The invention relates to self emulsifying drug delivery system based compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50®. The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools effects as compared to Art 50®. The invention also relates to methods for preparing such compositions.Type: ApplicationFiled: September 27, 2008Publication date: December 2, 2010Inventors: Premchand Nakhat, Prashant Mandaogade, Girish Kumar Jain, Munish Talwar
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Patent number: 7842679Abstract: Taught are pharmaceutical compositions comprising at least one phospholipid having at least one docosahexaenoyl (DHA) residue, such as a lecithin-DHA-type phospholipid, and methods for treating or preventing respiratory failure of a patient comprising administering these pharmaceutical compositions to a patient in need of such treatment or prevention.Type: GrantFiled: March 3, 2008Date of Patent: November 30, 2010Inventors: Gérard Pieroni, Thierry Coste
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Patent number: 7838027Abstract: Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.Type: GrantFiled: September 30, 2004Date of Patent: November 23, 2010Assignee: Wyeth LLCInventors: Sripriya Venkata Ramana Rao, Syed M. Shah, Hanumantharao Tatapudy, Richard William Saunders, Mahdi Fawzi, Arwinder Nagi, Shailesh Singh, Sumon A. Hasan
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Publication number: 20100291203Abstract: The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).Type: ApplicationFiled: May 24, 2010Publication date: November 18, 2010Applicant: PURDUE PHARMA L.P.Inventors: ROBERT F. KAIKO, Robert D. Colucci
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Publication number: 20100291202Abstract: The present invention relates to a pharmaceutical or nutraceutical preparation comprising a) a core containing a pharmaceutically or nutraceutically active substance and a substance that acts in a modulatory manner with regard of the release of pharmaceutically or nutraceutically active substances; and b) a controlling layer surrounding the core comprising i) 55 to 92% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate copolymers composed of 80 to 98% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from C1 to C4 alkyl esters of (meth)acrylic acid and 2 to 20% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from (meth)acrylate monomers with a quaternary ammonium group in the alkyl radical; and ii) 8 to 45% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate coType: ApplicationFiled: February 1, 2008Publication date: November 18, 2010Applicant: EVONIK ROEHM GMBHInventors: Hema Ravishankar, Shradda Bodinge, Hans-Ulrich Petereit
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Publication number: 20100291204Abstract: The invention relates to the combination of: a short-acting hypnotic agent which is selected from among a modulators of receptors GABA-A, a benzodiazepine, a phenothiazine, a melatonin derivative and a melatonin receptor agonist; and a long-acting hypnotic agent which is selected from among a modulator of receptors GABA-A, a benzodiazepine, an antagonist of receptors 5HT2A and a calcium ion modulator, for the treatment of sleep disorders. The invention also relates to galenic formulations containing said combinations.Type: ApplicationFiled: July 29, 2010Publication date: November 18, 2010Applicant: SANOFI-AVENTISInventors: Alain CUINE, Michel DECOBERT, Dominique FRANCON, Henry SAUNAL
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Publication number: 20100291201Abstract: Pharmaceutical compositions in unit dose form comprising a hard or soft capsule containing a fill consisting of one or more inert ingredients, and one or more coatings on the capsule, wherein at least one coating comprises at least one active pharmaceutical ingredient.Type: ApplicationFiled: May 14, 2009Publication date: November 18, 2010Applicant: CEROVENE, INC.Inventors: Manish S. SHAH, Ray J. Difalco
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Publication number: 20100285117Abstract: The present invention relates to combinations of triazine derivatives and of insulin sensitisers.Type: ApplicationFiled: December 18, 2006Publication date: November 11, 2010Inventors: Gérard Moinet, Daniel Cravo, Didier Mesangeau
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Publication number: 20100285118Abstract: Encapsulated omega-3 fatty acids and/or omega-6 fatty acids and/or esters thereof with a coating comprising isoflavones, as well as a process to make such by coating encapsulated omega-3 fatty acids and/or omega-6 fatty acids and/or esters thereof with a coating comprising isoflavones.Type: ApplicationFiled: October 9, 2008Publication date: November 11, 2010Inventors: Rob Dekker, Henk Husken
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Patent number: 7829115Abstract: The present invention relates to a pharmaceutical composition comprising micronized progesterone, soya bean lecithin, and at least one oil selected from the group consisting of sunflower oil, olive oil, sesame seed oil, colza oil, almond oil, to the method for the preparation thereof and to the uses thereof for treating a physiological condition linked to insufficiency of progesterone secretion.Type: GrantFiled: February 27, 2008Date of Patent: November 9, 2010Assignee: Besins Manufacturing BelgiumInventors: Antoine Besins, Jerome Besse
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Patent number: 7829080Abstract: The present invention provides a method for stabilizing reduced coenzyme Q10, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like. The present invention also provides a method of producing a reduced coenzyme Q10-containing composition which includes the co-presence of reduced coenzyme Q10 and reduced coenzyme Q9 and/or reduced coenzyme Q11.Type: GrantFiled: April 27, 2007Date of Patent: November 9, 2010Assignee: Kaneka CorporationInventors: Takahiro Ueda, Shiro Kitamura, Hiroshi Kubo, Kazunori Hosoe
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Publication number: 20100278910Abstract: Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed. The particles may be used in the gastrointestinal tract or the bloodstream to remove phosphate or to treat hyperphosphatemia in mammals. The particles may also be used to remove metals from fluids such as water.Type: ApplicationFiled: June 14, 2010Publication date: November 4, 2010Applicant: SPECTRUM PHARMACEUTICALS, INC.Inventors: Rudi E. Moerck, Timothy Malcome Spitler, Edward A. Schauer, Jan Prochazka
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Patent number: 7825120Abstract: Certain substituted ((piperazin-1-ylmethyl)benzyl)urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and may be useful in the treatment of systolic heart failure including congestive heart failure.Type: GrantFiled: December 13, 2006Date of Patent: November 2, 2010Assignee: Cytokinetics, Inc.Inventors: Bradley P. Morgan, Alex Muci, Erica A. Kraynack, Todd Tochimoto, Pu-Ping Lu, David J. Morgans, Jr.
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Publication number: 20100272793Abstract: The invention is for a method and composition for preparing a controlled release pharmaceutical formulation which can be used to administer Hydralazine hydrochloride over a 24 hours time frame, and for controlled release oral dosage forms of Hydralazine hydrochloride in the form of a tablet and a capsule.Type: ApplicationFiled: April 22, 2009Publication date: October 28, 2010Inventor: Navaneeta K. Gorrepati
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Publication number: 20100266683Abstract: The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising (i) a compound of the formula (I) (ii) one or more surfactants; (iii) optionally an oil or semi-solid fat; said composition forming an in-situ oil-in-water emulsion upon contact with aqueous media such as gastrointestinal fluids. The composition may optionally also comprise one or more short-chain alcohols. The pharmaceutical composition is useful in the treatment of pain and inflammation.Type: ApplicationFiled: April 28, 2010Publication date: October 21, 2010Applicant: NICOX S.A.Inventors: Christina HOLMBERG, Britta Siekmann
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Publication number: 20100260837Abstract: Pharmaceutical capsule compositions containing the active compound (2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide, and polyethylene glycol (PEG), Vitamin E polyethylene glycol succinate, polyvinylpryrrolidone (PVP) or copovidone (PVP-Polyvinyl acetate), with or without citric acid, are provided.Type: ApplicationFiled: April 12, 2010Publication date: October 14, 2010Inventors: Sachin Chandran, Rajesh Babulal Gandhi, Jaquan Kalani Levons, Robert Kevin Perrone, Christopher P. Price, Krishnaswamy Srinivas Raghavan, Ismat Ullah
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Publication number: 20100260836Abstract: The present invention relates to methods of co-administration of various vitamin and mineral compositions, and in a specific embodiment, said methods comprise co-administering one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states; and kits provided for co-administration of various vitamin and mineral compositions, and in a specific embodiment, said kits comprise one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states.Type: ApplicationFiled: April 10, 2009Publication date: October 14, 2010Inventors: John A. Giordano, Charles J. Balzer
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Publication number: 20100255086Abstract: A method for delivering acetyl salicylic acid to an individual via oral mucosal absorption by providing a melting capsule which includes a therapeutic amount of an acetyl salicylic acid; and administering the capsule sublingually in the patient such that the capsule melts at the individual's body temperature and delivers the acetyl salicylic acid directly into the bloodstream of the individual quickly and without complications; and a melting capsule comprised of a material that has the same melting point as the human body temperature and includes a therapeutic amount of an acetyl salicylic acid liquid or powder having a pH in the range of 2 to 7.Type: ApplicationFiled: April 5, 2010Publication date: October 7, 2010Inventor: Yoel Ovil
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Publication number: 20100255085Abstract: Fill materials for hydrophobic drugs, such as progesterone, and methods of making and using thereof are described herein. The fill material contains the hydrophobic drug dissolved in one or more fatty acids. The concentration of the hydrophobic drug is typically from about 7% to about 50% by weight of the fill material. The concentration of the one or more fatty acids is from about 60% to about 95% by weight of the carrier. The formulation also contains an organic acid and one or both of one or more pharmaceutically acceptable alcohols and one or more pharmaceutically acceptable mono-, di-, or triesters of medium or long chain fatty acids. The fill material can be encapsulated in a hard or soft capsule. The formulations described herein have a higher dissolution rate and faster onset of dissolution compared to micronized progesterone suspended in an oil and thus should have increased bioavailability in vivo.Type: ApplicationFiled: April 1, 2010Publication date: October 7, 2010Inventors: Zhi Liu, Saujanya L. Gosangari, Dana S. Toops, Aqeel Fatmi
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Patent number: 7807195Abstract: The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.Type: GrantFiled: January 7, 2005Date of Patent: October 5, 2010Assignee: Alembic LimitedInventors: Sampad Bhattacharya, Rajesh Kshirsagar, Mayank Joshi, Sandeep Pandita
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Publication number: 20100247640Abstract: The invention relates to a pharmaceutical composition and oral dosage forms comprising a bisphosphonate in combination with an enhancer to enhance intestinal delivery of the bisphosphonate to the underlying circulation. Preferably, the enhancer is a medium chain fatty acid or a medium chain fatty acid derivative having a carbon chain length of from 6 to 20 carbon atoms, and the solid oral dosage form is a controlled release dosage form such as a delayed release dosage form.Type: ApplicationFiled: April 26, 2010Publication date: September 30, 2010Inventor: Thomas W. Leonard
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Publication number: 20100247638Abstract: The present invention is in relation to an organoleptically improved dietary fiber composition from Trigonella foenum-graecum. In addition, the present invention provides a process to obtain an organoleptically improved dietary fiber composition comprising protein and galactomannans for treatment of diabetes.Type: ApplicationFiled: December 11, 2007Publication date: September 30, 2010Applicant: AVESTHAGEN LIMITEDInventors: Villoo Morawala Patell, Jagadeesh Badamaranahalli Henjarappa, SR., Kamalendra Singh, Chandramohan Bangalore Siddaiah
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Publication number: 20100247637Abstract: The invention concerns the use of a substance chosen among animal or vegetable gelatine, peptones, dextrins, native or modified cyclodextrins, starch, and starch hydrolysates in the preparation of pharmaceutical forms for the oral administration of thyroid hormones to combat the action of sequestrant agents present in the gastrointestinal tract, and related pharmaceutical forms.Type: ApplicationFiled: April 23, 2009Publication date: September 30, 2010Inventors: Giorgio Zoppetti, Paoio Mazzucchelli, Marta Riva
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Publication number: 20100247639Abstract: The present invention relates to a pharmaceutical or nutraceutical preparation comprising a) a core containing a pharmaceutically or nutraceutically active substance; and b) an inner controlling layer surrounding the core comprising i) one or a mixture of a plurality of (meth)acrylate copolymers bearing a cationic group or a group that can be converted to a cationic group; and ii) one or a mixture of a plurality of polymers or copolymers bearing an anionic group or group that can be converted to an anionic group; and c) an outer controlling layer comprising one or a mixture of a plurality of polymers or copolymers bearing an anionic group or group that can be converted to an anionic group and to tablets or capsules comprising same.Type: ApplicationFiled: February 1, 2008Publication date: September 30, 2010Applicant: EVONIK ROEHM GMBHInventors: Hema Ravishankar, Shradda Bodinge, Hans-Ulrich Petereit
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Publication number: 20100247634Abstract: The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.Type: ApplicationFiled: April 27, 2010Publication date: September 30, 2010Inventors: Aleksey Kostadinov, Ayelet David, Sabina Glozman
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Publication number: 20100247636Abstract: The present invention provides a composition comprising nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, useful in the treatment and prevention of hypertension or related cardiovascular disorders. In one embodiment, the composition comprises nanoparticulate particles comprising nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. In another embodiment, the composition comprises a modified release composition that, upon administration to a patient, delivers nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, in a bimodal, multimodal or continuous manner. The invention also relates to dosage forms containing such compositions, and to methods for the treatment and prevention of hypertension or related cardiovascular disorders.Type: ApplicationFiled: June 30, 2006Publication date: September 30, 2010Applicant: Elan Corporation, plcInventors: John G. Devane, Paul Stark, Niall M.M. Fanning, Gurvinder Singh Rekhi, Scott A. Jenkins, Gary Liversidge
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Publication number: 20100239663Abstract: This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. This invention relates also to food additives and food compositions and packages comprising the composition.Type: ApplicationFiled: May 22, 2007Publication date: September 23, 2010Applicant: BIOHIT OYJInventors: Osmo Suovaniemi, Ville Salaspuro, Martti Marvola, Mikko Salaspuro
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Publication number: 20100239664Abstract: The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them.Type: ApplicationFiled: February 25, 2009Publication date: September 23, 2010Applicant: SALIX PHARMACEUTICALS, LTD.Inventors: Karen S. Gushurst, Donglai Yang, Melanie Roe, Nathan Schultheiss, Petinka Vlahova, Jeffrey S. Stults, Travis L. Houston
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Patent number: 7799340Abstract: Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C6-C12 fatty acid monoglyceride content of at least about 50%, surfactants and triglycerides. The composition forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.Type: GrantFiled: March 15, 2007Date of Patent: September 21, 2010Assignee: Watson Laboratories, Inc.Inventors: Vinayak T. Bhalani, Satishchandra P. Patel
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Patent number: 7799341Abstract: Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by: (i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and (ii) extruding the melted mixture, to obtain an extruded mixture.Type: GrantFiled: June 10, 2004Date of Patent: September 21, 2010Assignee: McCormick & Company, Inc.Inventors: Michael A. Porzio, Dmitriy Zasypkin
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Publication number: 20100233255Abstract: The present patent application relates to novel combinations of a triazine derivative and of an insulin secretion stimulator.Type: ApplicationFiled: December 18, 2006Publication date: September 16, 2010Inventors: Gérard Moinet, Daniel Cravo, Didier Mesangeau
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Publication number: 20100233256Abstract: The present invention relates to methods and compositions effective in lowering blood pressure. The compositions comprise, as active ingredients, an effective amount of a combination of lycopene and a carotenoid, e.g., lutein. In a preferred embodiment, the lycopene and lutein together provide a synergistic therapeutic effect at lowering blood pressure. The compositions can further comprise additional agents such as carotenoids and other phytochemicals found in tomato oleoresin.Type: ApplicationFiled: July 10, 2008Publication date: September 16, 2010Applicant: LYCORED LTD.Inventors: Morris Zelkha, Esther Paran, Keren Hirsch
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Publication number: 20100226977Abstract: The invention relates to processing crustaceans such as krill to oils comprising phospholipids that are Newtonian fluids and/or and have low viscosity, and in particular to the production of oils containing astaxanthin and phospholipids that show Newtonian fluidity and have a low viscosity.Type: ApplicationFiled: February 24, 2010Publication date: September 9, 2010Applicant: AKER BIOMARINE ASAInventor: Snorre Tilseth
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Publication number: 20100221326Abstract: Pharmaceutical compositions are for administered orally for treating patients affected by obesity. The compositions include orlistat (tetrahydrolipstatin) solubilized in pharmaceutically acceptable saturated hydrocarbons obtained from petroleum and one or more surfactants.Type: ApplicationFiled: September 12, 2008Publication date: September 2, 2010Applicant: MADER S.R.L.Inventors: Guido Vandoni, Heny Cassia Zaniboni
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Publication number: 20100221325Abstract: The current invention presents a dietary supplement obtained from a mixture of melatonin, vitamins and aminoacids for healing or regressing symptoms of gastroesophageal reflux disease (such as heartburn, regurgitation, dysphagia, coughing, hoarseness, chest pain and odynophagia), gastritis and several types of ulcerations.Type: ApplicationFiled: January 19, 2007Publication date: September 2, 2010Inventor: Ricardo de Souza Pereira
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Publication number: 20100215738Abstract: The invention provides methods and compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a prebiotic composition, optionally in combination with effective amount of a probiotic microbe or microbes.Type: ApplicationFiled: February 17, 2010Publication date: August 26, 2010Applicant: Ritter Pharmaceuticals, Inc.Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Robert Klaenhammer
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Publication number: 20100215672Abstract: A composition which comprises extracts of a plant of the genus Poncirus. The composition effectively treats allergic conditions, atopic conditions, anaphylactic conditions, and autoimmune conditions.Type: ApplicationFiled: February 26, 2009Publication date: August 26, 2010Inventor: Charles R. de Charleroy, JR.
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Publication number: 20100215737Abstract: A modified release dosage product (5) comprises a plurality of minicapsules or minispheres (1, 2) containing nimodipine, and a plurality of minicapsules or minispheres (3), (4) containing tacrolimus. There are uncoated minicapsules or minispheres (1) encapsulating micronized nimodipine for immediate release and a controlled release polymer coated minicapsule or minisphere (2) encapsulating micronized nimodipine for delayed, sustained, controlled or targeted release. There are uncoated seamless minicapsules (3), the core of which comprises tacrolimus lipid-based formulation for immediate release and a controlled release polymer coated seamless minicapsule (4), the core of which comprises tacrolimus lipid-based formulation for delayed, sustained, controlled release or targeted release. The final dosage form may be a hard gelatin capsule (5).Type: ApplicationFiled: May 1, 2008Publication date: August 26, 2010Inventor: Ivan Coulter
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Publication number: 20100209497Abstract: The present disclosure provides for a scientific formulation useful in the treatment and prevention of human and animal diseases. A biologically effective amount of each of the components of the formulation is administered to patients in pill (or capsule) form via multiple different and identifiable pills. The compounds of the formulation are segregated into different pill types, and contain various amounts of the compounds Curcumin, Genistein, Squalamine, Vitamin E, N-Acetyl-Cysteine, Methylselenocysteine, Zinc Gluconate, B Complex, Lentinen, Coenzyme Q10 Acetyl-L-Carnitine, Lipoic Acid, Resveratrol, and Vitamin C. Furthermore, Arabinoxylan and/or Peperine may be added to the various pill formulations.Type: ApplicationFiled: February 19, 2009Publication date: August 19, 2010Inventor: Jerry T. Thornthwaite
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Publication number: 20100209499Abstract: The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug and an enhancer wherein the enhancer is a medium chain fatty acid ester, ether or salt or a derivative of a medium chain fatty acid, which is, preferably, solid at room temperature and which has a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is controlled release dosage form such as a delayed release dosage form.Type: ApplicationFiled: April 27, 2010Publication date: August 19, 2010Inventors: Kenneth I. Cumming, Zebunnissa Ramtoola
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Publication number: 20100209498Abstract: The present invention relates to pharmaceutical compositions of duloxetine or pharmaceutically acceptable salts thereof, and processes for their preparation.Type: ApplicationFiled: April 19, 2008Publication date: August 19, 2010Inventors: Girish Kumar Jain, Chandrashekhar Kandi, Vishwanath Nande
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Publication number: 20100203122Abstract: A remote treatment delivery system comprising a substantially non-skin piercing dosage projectile containing a biologically active agent and a transdermal carrier.Type: ApplicationFiled: October 31, 2007Publication date: August 12, 2010Inventors: Grant Weyer, Simon Robert Sanford Trickey, Timothy Donald Rose
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Publication number: 20100203123Abstract: The present invention is directed to methods of improving cognitive function in subjects having age related cognitive decline or mild cognitive impairment and to methods of decreasing heart rate in a subject by administering dosage forms comprising docosahexaenoic acid (DHA) substantially free of eicosapentaenoic acid (EPA).Type: ApplicationFiled: February 2, 2010Publication date: August 12, 2010Applicant: MARTEK BIOSCIENCES CORPORATIONInventor: Karin YURKO-MAURO
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Publication number: 20100203120Abstract: An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin A in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The composition may be used for treating a range of intestinal diseases [FIG. 10].Type: ApplicationFiled: April 4, 2008Publication date: August 12, 2010Inventor: Ivan Coulter
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Publication number: 20100203124Abstract: The present invention is directed to a kappa-2 carrageenan composition comprising: (i) kappa-2 carrageenan, (ii) at least 70% sodium by weight of all cations in the composition; and (iii) free salt present in an amount of 0-25% by weight of the composition; wherein the composition has a viscosity of 20 cps to 40 cps. The present invention is also directed to products made from such kappa-2 carrageenan composition, as well as to processes of manufacture and use thereof.Type: ApplicationFiled: April 7, 2010Publication date: August 12, 2010Applicant: FMC CORPORATIONInventors: James J. Modliszewski, Robert Kopesky, Christopher J. Sewall
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Publication number: 20100196467Abstract: The present invention especially relates to the use of a combination comprising (1) an ACEI selected from the group consisting of benazepril, benazeprilat, and pharmaceutically acceptable salts thereof, and (2) amlodipine or pharmaceutically acceptable salt thereof, for the manufacture a medicament for the treatment or prevention or delay of progression of a condition selected from the group consisting of hypertension, congestive heart failure, angina, myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, blood pressure-related cerebrovasular disease, stroke, pulmonary disease or pulmonary hypertension and headache; wherein (i) the amount of amlodipine or a pharmaceutically acceptable salt thereof corresponds to 6 about mg to 40 about mg of the free base and (ii) the amount of the ACE inhibitor or a pharmaceutically thereof corresponds to 20 about mg to 160 about mg ofType: ApplicationFiled: April 16, 2010Publication date: August 5, 2010Inventors: William Lionel Daley, Randy Lee Webb, Ann Reese Comfort, Santo Joseph Fleres, Alan Edward Royce, William Shifeng Wei
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Publication number: 20100196468Abstract: Stable pharmaceutical composition consisting of a hydrosoluble vinflunine salt and at least one diluent and one lubricant, said composition being in the form of a solid intended for oral administration. The hydrosoluble vinflunine salt is preferably Vinflunine ditartrate. The pharmaceutical composition is advantageously in the form of a capsule or tablet. The invention also concerns a method of treating cancer pathology comprising the oral administration of the pharmaceutical composition of the invention.Type: ApplicationFiled: July 9, 2008Publication date: August 5, 2010Applicant: Pierre Fabre MedicamentInventors: Bruno Paillard, Jean-Louis Avan, Joël Bougaret
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Publication number: 20100189781Abstract: Disclosed are alkoxyalkyl S-prenylthiosalicylates and pharmaceutical compositions containing the same and a pharmaceutically acceptable carrier. Methods for treating a human afflicted with cancer, including solid tumors, or a hematological malignancy by administering to the human in need thereof an effective amount of an alkoxyalkyl S-prenylthiosalicylate are also disclosed.Type: ApplicationFiled: January 20, 2010Publication date: July 29, 2010Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., CONCORDIA PHARMACEUTICALS, INC.Inventors: Yoel Kloog, Liat Goldberg, Victor J. Bauer
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Patent number: 7763276Abstract: A soft capsule in which a shell is filled with fill material, and the fill material is in a solid or semi-solid form at room temperature. The soft capsule may be a chewable capsule, and the fill material may comprise a low melting point additive. The content of the low melting point additive may be 10% or more with respect to the total weight of the fill material, and may have a melting point of about 20 to 50° C. The low melting point additive may be selected from the group consisting of chocolate base, lard, coconut oil and macrogol (polyethylene glycol) as well as a combination thereof.Type: GrantFiled: February 23, 2000Date of Patent: July 27, 2010Assignee: Shionogi & Co., Ltd.Inventors: Hidekazu Shodai, Noboru Nagafuji, Toshitada Toyoda, Yuka Okada
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Pharmaceutical compositions for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis
Publication number: 20100183711Abstract: The present invention provides methods for reducing A? deposition, A? neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyridine compound nilvadipine, also known as (?)-nilvadipine, to the animal or human. Further provided are methods for reducing the risk of A? deposition, A? neurotoxicity and microgliosis in animals or humans suffering from traumatic brain injury by administering (?)-nilvadipine after the traumatic brain injury and continuing treatment for a prescribed period of time thereafter.Type: ApplicationFiled: February 1, 2010Publication date: July 22, 2010Inventors: Michael J. Mullan, Daniel Paris, Robert A. Ivey, III