Tablets, Lozenges, Or Pills Patents (Class 424/464)
With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.) (Class 424/465)
Effervescent (Class 424/466)
Printed, embossed, grooved, or perforated (Class 424/467)
Sustained or differential release type (Class 424/468)
Coated pills or tablets (Class 424/474)
  • Agonists of neurotrophin receptors and their use as medicaments
    Patent number: 8791076
    Abstract: The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are agonists of neurotrophin (such as nerve growth factor) receptors.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: July 29, 2014
    Inventors: Pablo Villoslada, Angel Messeguer
  • Direct Compression Formulation and Process
    Publication number: 20140205663
    Abstract: Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of direct compressed with specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus present formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 24, 2014
    Applicant: Novartis AG
    Inventors: James Kowalski, Jay Parthiban LakShman, Arun P. Patel
  • METHOD FOR PRODUCING FINELY DIVIDED HAEMATITE AND FOR PRODUCING IRON OXIDE RED PIGMENTS
    Publication number: 20140205664
    Abstract: The present invention relates to an improved process for the production of finely divided haematite and of iron oxide red pigments made up of the finely divided haematite and the use of the finely divided haematites and iron oxide red pigments produced by this process.
    Type: Application
    Filed: September 28, 2012
    Publication date: July 24, 2014
    Applicant: LANXESS DEUTSCHLAND GmbH
    Inventors: Guido Ketteler, Udo Holtmann, Juergen Kischkewitz
  • Controlled release and taste masking oral pharmaceutical composition
    Patent number: 8784888
    Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 22, 2014
    Assignee: Cosmo Technologies Limited
    Inventors: Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
  • Small-volume oral transmucosal dosage forms
    Patent number: 8778394
    Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: July 15, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
  • Flurbiprofen and muscle relaxant combinations
    Patent number: 8778391
    Abstract: This invention is a novel pharmaceutical composition comprising flurbiprofen or a pharmaceutically acceptable salt thereof in combination with an ?-2 adrenergic receptor agonist or a gamma-aminobutiric acid receptor agonist with anti-inflammatory, analgesic and myorelaxant activity.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: July 15, 2014
    Assignee: Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi
    Inventors: Umit Cifter, Ali Turkyilmaz, Hasan Ali Turp
  • Oral disintegrating tablet
    Patent number: 8778392
    Abstract: An oral disintegrating tablet containing (1) D-mannitol, (2) an active ingredient, (3) one or more disintegrating agents selected from the group consisting of crospovidone and carmellose, and (4) one or more lubricants selected from the group consisting of sodium stearyl fumarate and sucrose esters of fatty acids. The oral disintegrating tablet of the present invention has some excellent properties of (1) allowing easy production in a common facility without necessitating a specialized pharmaceutical technique, (2) having an appropriate strength that does not breakdown in the process of distribution, (3) having a fast disintegrating ability in the oral cavity, and (4) also having excellent ingestion feel such as greatly reduced bitterness or gritty feel; therefore, the tablet can be suitably used as a dosage form that is suitable for aged individuals, children, and seriously ill patients.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: July 15, 2014
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Makoto Matsuoka, Hiroyuki Nishii, Maki Kawamura
  • Saccharide free, storage stable thyroid hormone active drug formulations and methods for their production
    Patent number: 8779000
    Abstract: Embodiments of the present invention provide pharmaceutical compositions in unit dosage form that comprise a therapeutically effective amount of levothyroxine sodium; an antioxidant in an amount sufficient to stabilize the levothyroxine sodium against oxidation; an amount of an alditol sufficient to stabilize the levothyroxine sodium; and at least two excipients selected from a filler, a binder, and a lubricant. Such compositions are free of added monosaccharide, disaccharide, and an oligosaccharide and are storage stable.
    Type: Grant
    Filed: July 20, 2013
    Date of Patent: July 15, 2014
    Inventors: Nilesh Parikh, William Hite
  • Stabilized tolterodine tartrate formulations
    Patent number: 8778397
    Abstract: A method of making a pharmaceutical composition containing tolterodine L-tartrate stabilized against degradation with an acid. Acid-stabilized tolterodine L-tartrate may be used as an active ingredient in various types of immediate release and controlled release dosage forms, including tablets, capsules, and beads.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: July 15, 2014
    Assignee: Mylan, Inc.
    Inventors: David T. Rossi, Boyong Li, James Paul McCall
  • Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
    Patent number: 8778393
    Abstract: Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: July 15, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards
  • PHARMACEUTICAL ANTIRETROVIRAL COMPOSITION
    Publication number: 20140193491
    Abstract: The present invention relates to a pharmaceutical antiretroviral composition comprising (i) a nucleoside reverse-transcriptase inhibitor selected from lamivudine and emtricitabine, (ii) extended release nevirapine, and (iii) tenofovir; a process for preparing such composition and the use of such composition in medicine, particularly for the prophylaxis and/or treatment of diseases caused by retroviruses.
    Type: Application
    Filed: May 30, 2012
    Publication date: July 10, 2014
    Applicant: CIPLA LIMITED
    Inventors: Geena Malhotra, Shrinivas Madhukar Purandare
  • CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
    Publication number: 20140193495
    Abstract: The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.
    Type: Application
    Filed: March 13, 2014
    Publication date: July 10, 2014
    Applicant: FORWARD PHARMA A/S
    Inventors: Henrik NILSSON, Florian SCHOENHARTING, Bernd W. MUELLER, Joseph R. ROBINSON
  • METHOD FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION COMPRISING 5-AMINOSALICYLIC ACID FOR USE IN TREATMENT OF ULCERATIVE COLITIS AND CROHN'S DISEASE
    Publication number: 20140193492
    Abstract: The present invention concerns a new method of preparing granules comprising 5-aminosalicylic acid and a new method of preparing a pharmaceutical composition for the treatment of ulcerative colitis or Crohn's disease by oral administration comprising as active ingredient 5-aminosalicylic acid.
    Type: Application
    Filed: December 19, 2013
    Publication date: July 10, 2014
    Applicant: Ferring B.V.
    Inventor: Svenn Kluver Jepsen
  • Carbidopa/Levodopa gastroretentive drug delivery
    Patent number: 8771730
    Abstract: A gastroretentive drug formulation for the sustained release of an active agent in the gastrointestinal tract comprises an internal layer or compartment comprising an active agent and one or more pharmaceutical excipients, of which at least one is a polymer and two membranes forming together an envelope around the inner membrane, each membrane comprising at least one polymeric combination of an enteric polymer which is not soluble in gastric juice, and an hydrophilic swelling polymer, and at least one plasticizer.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: July 8, 2014
    Assignee: Intec Pharma Ltd.
    Inventors: Nadav Navon, Eytan Moor, David Kirmayer, Elena Kluev, Giora Carni
  • Pharmaceutical composition containing an anti-nucleating agent
    Patent number: 8771733
    Abstract: Pharmaceutical compositions suitable for oral administration in solid dosage forms are described. The compositions comprise an effective amount of a drug compound in the form of a salt, wherein the drug salt is characterized by conversion to a less soluble form of the drug compound under certain pH conditions, and an anti-nucleating agent.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: July 8, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Maria T. Cruanes, Wei Xu, Laura M. Artino, Honggang Zhu
  • Sustained release formulations of nalbuphine
    Patent number: 8771732
    Abstract: Sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof to treat patients suffering from pain are provided.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: July 8, 2014
    Assignee: Endo Pharmaceuticals Inc
    Inventors: Anand R. Baichwal, Philip A. Goliber, Anthony E. Carpanzano, Thomas Sciascia, Donald Diehl, II, Brian Vogler
  • Pharmaceutical compositions for poorly soluble drugs
    Patent number: 8771739
    Abstract: The present invention provides a pharmaceutical composition of a practically insoluble drug, wherein the composition may be administered with food or without food. The composition may be in the form of a solid dispersion of the practically insoluble drug and a polymer having acidic functional groups, and the composition may in vitro form a suspension.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: July 8, 2014
    Assignee: Mayne Pharma International Pty Ltd
    Inventors: David Hayes, Angelo M. Morella
  • Sustained release formulation of nalbuphine
    Patent number: 8765175
    Abstract: Sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof to treat patients suffering from pain are provided.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: July 1, 2014
    Assignee: Endo Pharmaceuticals Inc
    Inventors: Anand R. Baichwal, Philip A. Goliber, Anthony E. Carpanzano, Thomas Sciascia, Donald Diehl, II, Brian Vogler, David Verbel, Stanley Au
  • Aqueous composition
    Patent number: 8765187
    Abstract: Disclosed is an aqueous composition containing (a) an ethyl acrylate/methyl methacrylate copolymer or a plasticized vinyl accetate polymer, (b) an ethyl cellulose, (c) a water soluble additive for pharmaceutical products, (d) titanium oxide and (c) water. The solid content mass ratio among the components (a), (b), (c) and (d), namely a:b:c:d is 100:(5-50):(1-50):(0.5-10), and the solid content concentration in the aqueous composition is 0.5-40% by mass.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: July 1, 2014
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Yoshihito Yaginuma, Naoya Yoshida
  • Transmucosal effervescent
    Patent number: 8765100
    Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of additional pH adjusting substance in combination with the effervescent for promoting the absorption of drugs is also disclosed.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: July 1, 2014
    Assignee: Cephalon, Inc.
    Inventors: Jonathan D. Eichman, John Hontz, Rajendra K. Khankari, Sathasivan Indiran Pather, Joseph R. Robinson
  • Chewable enteric coated aspirin tablets
    Patent number: 8758814
    Abstract: The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated aspirin active ingredient, and preferably a lightly compressed matrix comprising directly compressible carbohydrate(s) and at least one sweetener.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: June 24, 2014
    Assignee: McNeil-PPC, Inc.
    Inventors: Manoj N. Shah, James S. Beahm, Robert Shen
  • Pharmaceutical compositions comprising a combination of metformin and sitagliptin
    Patent number: 8758815
    Abstract: The present invention relates to a pharmaceutical composition, preferably a pharmaceutical dosage form, comprising at least two separate compartments, wherein one compartment contains a composition comprising metformin or a pharmaceutically acceptable salt thereof and wherein another compartment contains a composition comprising sitagliptin. The present invention also relates to a process for preparing dosage forms comprising metformin or a pharmaceutically acceptable salt thereof and sitagliptin or a pharmaceutically acceptable salt thereof, the process comprising the steps of: a) providing one composition containing metformin or a pharmaceutically acceptable salt thereof and optionally also sitagliptin, b) providing a further composition containing sitagliptin or a pharmaceutically acceptable salt thereof and optionally also metformin, and c) combining the compositions to form compartments.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: June 24, 2014
    Assignee: Lek Pharmaceuticals D.D.
    Inventors: Polona Smrdel, Tijana Stanic Ljubin, Luka Peternel, Uros Klancar
  • Sublingual buccal effervescent
    Patent number: 8753611
    Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: June 17, 2014
    Assignee: Cephalon, Inc.
    Inventors: Jonathan D. Eichman, John Hontz, Rajendra K. Khankari, Sathasivan Indiran Pather, Joseph R. Robinson
  • Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
    Patent number: 8753675
    Abstract: The present invention relates to a reduced form of Coenzyme Q also known as ubiquinol in oral dosage form such as a gelatin capsule, preferably a soft gelatin capsule. Compositions according to the present invention include storage stable compositions comprising effective amounts of ubiquinol in combination with an amount of a reducing agent effective to maintain ubiquinol in its reduced state when formulated in capsules, tablets and other orally administrable form. Methods of using these compositions in the treatment of a number of disease states or conditions are also disclosed.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: June 17, 2014
    Inventor: Raj K. Chopra
  • MULTI-NUTRIENT SUPPLEMENT AND USES THEREOF
    Publication number: 20140161878
    Abstract: Various embodiments of the invention relate to compositions comprising vitamins, minerals and trace elements, antioxidants, amino acids, probiotics, and other components and methods for using such compositions to treat or prevent diseases associated with oxidative stress, including cardiovascular disease.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 12, 2014
    Applicant: Sweet Wellness AB
    Inventor: Per-Arne Öckerman
  • Modified release formulations containing drug-ion exchange resin complexes
    Patent number: 8747902
    Abstract: An aqueous liquid suspension containing a coated drug-ion exchange resin complex comprising a core composed of an amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine-ion exchange resin complex is provided. The coated amphetamine-ion exchange resin complex is in admixture with a polymer to form a matrix. Methods of making the coated complex and the liquid suspension are described.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: June 10, 2014
    Assignee: TRIS Pharma, Inc.
    Inventors: Ketan Mehta, Yu-Hsing Tu
  • Pharmaceutical Composition for Treatment of Helicobacter Pylori Associated Diseases
    Publication number: 20140154317
    Abstract: An oral pharmaceutical composition for the treatment of helicobacter pylori associated diseases is disclosed comprising a proton pump inhibitor, an antibiotic or a combination of antibiotics, and additionally at least one agent selected from the group consisting of a) taurolidine or taurultam or a combination thereof, b) a zinc amino acid chelate, c) tromethamole, within a fixed-dose combination for oral administration in the form of either an instant release formulation, for example a compressed tablet, granules or the like, or in the form of a biphasic release form, for example a tablet with a slow release core and a compressed outer fast release layer, wherein the tromethamole is always present in instant release formulations.
    Type: Application
    Filed: December 3, 2013
    Publication date: June 5, 2014
    Inventor: Abo Bakr Mohammed Ali Al-Mehdar
  • Dispersible tablet
    Patent number: 8741344
    Abstract: The present invention relates to a tablet comprising Nimorazole. In particular, the invention concerns a pharmaceutical composition or a tablet comprising Nimorazole or a pharmaceutically acceptable salt, for dispersion in water and administration via a tube to a patient with swallowing difficulties.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: June 3, 2014
    Assignee: Azanta A/S
    Inventors: Nilesh Tanhaji Dumbre, Mahesh Mohanrao Bhadgale, Vardhaman Chandrakant Bafna
  • Preparation and Use of Combination Enzyme and Gastrointestinal Modulator Delivery Systems
    Publication number: 20140147500
    Abstract: Pharmaceutical compositions comprising one or more digestive enzymes and one or more gastrointestinal modulators of acid are provided. The one or more digestive enzymes may be coated, e.g., with a lipid. Also disclosed are methods for their use and controlled delivery in treating individuals with neurological, behavioral, infectious, or genetic diseases or conditions susceptible to treatment with digestive enzymes.
    Type: Application
    Filed: November 19, 2010
    Publication date: May 29, 2014
    Inventors: Joan M. Fallon, Matthew Heil, James F. Szigethy, James Fallon
  • Device, method and compositions for reducing the incidence of tobacco smoking
    Patent number: 8733368
    Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: May 27, 2014
    Assignee: Smoke-Break, Inc.
    Inventors: Brett J. Roth, Terrill S. Clayton
  • Dissolvable TableT
    Publication number: 20140141078
    Abstract: A dissolvable tablet is disclosed. The tablet includes a front side, an obverse side and a thickness between the front side and the obverse side. The front side and obverse side have a variation of convex and concave surfaces. The convex and concave surfaces allow for a plurality of dissolvable tablets to be stacked for packaging. Further, the variation of convex and concave surfaces allow for a self-agitation when the dissolvable tablet is dissolved within a liquid.
    Type: Application
    Filed: September 13, 2013
    Publication date: May 22, 2014
    Inventor: Jeffery K. Slaboden
  • MICROLAYER COEXTRUSION TO CREATE A TIME-RELEASE DRUG SUBSTANCE DELIVERY PRODUCT
    Publication number: 20140141053
    Abstract: The present invention relates to medical devices containing time-release drug substance, and more particularly, to medical tubing, catheters, stents, cables (including fiber optic cables), pills, capsules, sheaths, threads, clamps, sutures, and endotracheal devices. The invention also generally relates to a method for extruding multiple laminated flow streams using microlayer coextrusion to create these various time-release drug delivery products.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 22, 2014
    Applicant: Guill Tool & Engineering Co., Inc.
    Inventors: Richard R. Guillemette, Robert G. Peters, Christopher Hummel
  • Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells
    Patent number: 8728521
    Abstract: The present invention incorporates medicaments in the empty hard capsule shells (body and cap). The medicament is either physically/molecularly distributed and/or chemically bound to the polymer matrix of the capsule shell composition. Other medicaments in the form of drug-loaded matrices (powders, granules, beads, pellets, mini-tablets, and mini-capsules) can be filled in the drug-loaded empty, hard capsule shells. The same capsule dosage form contains medicaments in the core matrix and in the shell.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: May 20, 2014
    Assignees: Tara Innovations LLC
    Inventor: Hemant Narahar Joshi
  • Sublingual buccal effervescent
    Patent number: 8728441
    Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: May 20, 2014
    Assignee: Cephalon, Inc.
    Inventors: Jonathan D. Eichman, John Hontz, Rajendra K. Khankari, Sathasivan Indiran Pather, Joseph R. Robinson
  • Oral hygiene tablets and capsules for direct oral delivery of active ingredients
    Patent number: 8728446
    Abstract: An oral hygiene tablet or capsule for direct oral delivery of active ingredients to humans and animals is provided composed of a tablet or capsule having an outer shell and inner cavity containing an active ingredient. Active ingredients contained and delivered by the oral hygiene tablet include mouthwash, toothpaste, medicament, mouth soothing and numbing agents, fluoride rinse, joint preserving agents, vitamins and herbal supplements. Other ingredients, such as flavor enhancers, scents, colorings and sugars may be included in the composition of the tablet or capsule. Delivery of the supplement ingredients is effectuated by simply placing the tablet into the mouth and allowing saliva to cause the outer shell to dissolve. The dissolution process can be accelerated by biting of the tablet/capsule and breaking it into smaller particles and/or by drinking water when the tablet is inserted into the mouth.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: May 20, 2014
    Assignee: I Did It, Inc.
    Inventor: Marni Markell Hurwitz
  • Butylphthalide self-emulsifying drug delivery system, its preparation and method and application
    Patent number: 8728518
    Abstract: The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 20, 2014
    Assignee: CSPC ZhongQi Pharmaceutical Technology (Shijiazhuang) Co., Ltd
    Inventors: Zhentao Liu, Liying Yang, Hanyu Yang, Yuqing Gao, Dongmin Shen, Wenmin Guo, Xiaolong Feng, Jia Zheng
  • Pharmaceutical compositions for treating or preventing pain
    Patent number: 8728522
    Abstract: Methods and compositions are provided which comprise effective amounts of one or more analgesics, such as hydrocodone or acetaminophen, and an antiemetic, such as promethazine, to treat a subject, including reducing or eliminating an adverse effect associated with the analgesics.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: May 20, 2014
    Assignee: Charleston Laboratories, Inc.
    Inventors: Paul Bosse, John Ameling, Bernard Schachtel, Ray Takigiku
  • IBUPROFEN CHEWABLE TABLET
    Publication number: 20140134245
    Abstract: The present invention relates to a taste masked and directly compressed ibuprofen chewable tablet comprising therapeutically effective amount of ibuprofen having average particle size between 250 ?m and 400 ?m, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 18, 2012
    Publication date: May 15, 2014
    Applicant: Sino-American Tianjin SmithKline and French Lab., LTD
    Inventors: Lei Yang, Fang Yang, John Jiangnan Liu
  • ANTIFUNGAL COMPOSITIONS WITH IMPROVED BIOAVAILABILITY
    Publication number: 20140134244
    Abstract: The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form can be administered once daily, and in addition at any time of the day independently of the food taken in by said mammal. These novel compositions comprise particles obtainable by melt-extruding a mixture comprising itraconazole and an appropriate water-soluble polymer and subsequently milling said melt-extruded mixture.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 15, 2014
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Lieven E.C. Baert, Geert Verreck, Dany Thone
  • Methods for administering weight loss medications
    Patent number: 8722085
    Abstract: Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: May 13, 2014
    Assignee: Orexigen Therapeutics, Inc.
    Inventors: Anthony McKinney, Gary Tollefson, Eckard Weber, Rick Soltero
  • Method for production of orally rapidly disintegrating tablet comprising imidafenacin as active ingredient
    Patent number: 8722133
    Abstract: The present invention herein provides an imidafenacin-containing orally rapidly disintegrating tablet which is excellent in the photostability. The present invention comprises the steps of: (A) granulating imidafenacin together with starch to thus give a granulated product having an imidafenacin concentration ranging from 0.001 to 3% by mass and a starch concentration ranging from 40 to 99.999% by mass; (B) covering the granulated product prepared in the step (A) with a non-cellulosic coating agent; and (C) blending the granulated product obtained in the preceding step (B) with an excipient and a disintegrating agent and then forming the resulting mixture into a tablet according to the compression molding technique.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: May 13, 2014
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Toshihiro Ishizaki, Yoshinobu Aoki
  • Use of R(+)-alpha-lipoic acid for cryptogenic neuropathy
    Patent number: 8722013
    Abstract: The present invention relates to the use of R(+)-alpha-lipoic acid ((R)-5-(1,2-dithiolan-3-yl)valeric acid) and/or of a physiologically acceptable derivative of this compound for cryptogenic neuropathy.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: May 13, 2014
    Assignee: Encrypta GmbH
    Inventor: Klaus Wessel
  • Granulate comprising an oily substance, corresponding production method and tablet
    Patent number: 8722090
    Abstract: The invention relates to a process for the preparation of granules comprising an oily substance. It relates also to granules for a pharmaceutical formulation and to a tablet as a product of further processing.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: May 13, 2014
    Assignee: Hexal AG
    Inventors: Karin Klokkers, Ina Elfriede Otto, Heidemarie Edith Elfriede Meyer
  • Dip coated compositions containing a starch having a high amylose content
    Patent number: 8722089
    Abstract: The present invention features a method of making a coated tablet by dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on the core, wherein the coating liquid contains at least one a starch having an amylose content of at least about 50 percent by weight of said starch.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: May 13, 2014
    Assignee: McNeil-PPC, Inc.
    Inventor: Jen-Chi Chen
  • PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ADMINISTRATION OF HEPARIN OR DERIVATIVES THEREOF
    Publication number: 20140127292
    Abstract: Oral pharmaceutical compositions for the controlled release of heparin or derivatives thereof, for example dalteparin, salts and/or derivatives thereof, comprising (a) a matrix consisting of amphiphilic compounds and lipophilic compounds with melting point lower than 90° C. in which the active ingredient is at least partially dispersed; (b) an outer hydrophilic matrix in which the lipophilic/amphiphilic matrix is dispersed; (c) optionally, other excipients suitable for solid pharmaceutical forms. The treatment of inflammatory bowel diseases (IBD) by administering to a patient in need thereof an effective amount of dalteparin, salts and/or derivatives thereof is also disclosed.
    Type: Application
    Filed: December 30, 2013
    Publication date: May 8, 2014
    Applicant: Cosmo Technologies Limited
    Inventors: Mauro Ajani, Luigi Moro, Roberto Villa
  • Calcium Carbonate Granulation
    Publication number: 20140127293
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Application
    Filed: January 15, 2014
    Publication date: May 8, 2014
    Applicant: DELAVAU L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Pharmaceutical composition comprising tramadol and ketoprofen in association
    Patent number: 8715726
    Abstract: The present invention relates to a pharmaceutical composition comprising a combination of active principles. More specifically: a stable pharmaceutical composition comprising a combination of tramadol and ketoprofen. Furthermore, a combination in solid form in which the active principles are vehicled in pharmaceutical forms and/or products that prevent contact between them. Complementarily, the present invention also relates to the combined use of ketoprofen and tramadol in the preparation of an oral medicine useful for relieving pain as well as a method for relieving pain with an oral pharmaceutical composition comprising a combination of tramadol and ketoprofen.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: May 6, 2014
    Assignee: Eurofarma Laboratories S.A.
    Inventors: Dante Alario Junior, Henry Jun Suzuki
  • Secure tracking of tablets
    Patent number: 8715725
    Abstract: The present invention relates to a verification method for tracking and tracing tablets, particularly pharmaceutical tablets. It further relates to a visible secure marking or information that is a part of such tablet (10). The invention further relates to tablets suitable for such verification method, processes for manufacturing such tablets, and methods for reading the information.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: May 6, 2014
    Assignee: I-Property Holding Corp.
    Inventors: Alexander Stuck, Stefan Klocke, Harald Walter
  • Stabilised supersaturated solids of lipophilic drugs
    Patent number: 8715735
    Abstract: Methods for improving solubility and bioavailability of lipophilic compounds are described. Particularly, described are stabilized supersaturated solid solutions, particularly in power from, of lipophilic drugs, such as steroidal molecules.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: May 6, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Adrian Funke, Torsten Wagner, Ralph Lipp
  • Process of reducing the bitter taste of water soluble actives by co-grinding the active with ? cyclodextrin
    Patent number: 8715731
    Abstract: A process for reducing the intensity of the intrinsic bitter taste of a water soluble active which comprises dry mixing of said active with ?-cyclodextrin.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: May 6, 2014
    Assignee: ISP Investments Inc.
    Inventors: Rama Haldar, Dipan Ray, Deborah Tobia, Donald Koelmel, Sidney Etienne