Abstract: Packaging systems are configured for improving long-term stability of a composition. Packaging systems may include a packaging container defining an enclosed volume. The packaging system may additionally include a removable cover that enables the packaging container to be opened and closed such that the packaging container system includes a sealed or sealable volume to contain a main composition in fluid communication with a sacrificial composition. The main composition may include one or more volatile or gas-releasing materials and the sacrificial material may include a stabilizing component that replaces the at least one volatile or gas-releasing component within the main composition or displaces the at least one volatile or gas-releasing component within the enclosed volume. The sacrificial composition helps maintain stability of the main composition by accelerating equilibrium of vapors or gases within the headspace of the sealed interior volume.

Abstract: A dental wrap is provided. The dental wrap includes an adhesive layer and a backing layer, which is characterized in that it does not contain an active ingredient. The present invention can improve the user's feeling of use by applying various flavors that were difficult to use in the tooth whitening agent.

Abstract: The disclosed invention provides an antibacterial pro-coagulant formula for assisting in combating the condition of bleeding gums caused by periodontal disease and gingivitis that enhances the natural healing process by assisting in the of cessation of bleeding by providing an “anti-bacterial oral healing environment” accompanied by enhanced blood flow to the affected bleeding area for more rapid blood clotting and increased blood flow to the affected area to assist the body's natural process of rebuilding healthy gum-tissue. Additionally, the disclosed invention with its antibacterial benefits, when used topically, provides for rapid surface skin blood clotting as well as increased blood circulation on the skin surface which greatly aids in the healing of external skin cuts, such as nicks from shaving or against inflammation of the skin from acne vulgaris.

Abstract: The present invention is a formable dental treatment tray utilizing poly(2-ethyl-2-oxazoline) and a gelatinous active. Blending of the active is accomplished by mixing the Poly(2-ethyl-2-oxazoline) with an active ingredient, such as a peroxide like hydrogen peroxide, carbamide peroxide, sodium perborate, or sodium percarbonate, usually also with water or an appropriate organic solvent. Peroxide concentrations in these new gels can reach a 30% concentration of hydrogen peroxide while maintaining a shelf life of six months at room temperature without developing peroxide decomposition. The gels are applied to an appropriate backing and dried to a gelatinous state. In use, the active is hydrated and regains adhesiveness. Then the tray is pressed and formed around a user's dental arch to form the customizable tray. Multiple active ingredients may be used, with or without peroxide, for accomplishing desired treatment regimens.

Abstract: The present invention is a formable dental treatment tray utilizing poly(2-ethyl-2-oxazoline) and a gelatinous active. Blending of the active is accomplished by mixing the Poly(2-ethyl-2-oxazoline) with an active ingredient, such as a peroxide like hydrogen peroxide, carbamide peroxide, sodium perborate, or sodium percarbonate, usually also with water or an appropriate organic solvent. Peroxide concentrations in these new gels can reach a 30% concentration of hydrogen peroxide while maintaining a shelf life of six months at room temperature without developing peroxide decomposition. The gels are applied to an appropriate backing and dried to a gelatinous state. In use, the active is hydrated and regains adhesiveness. Then the tray is pressed and formed around a user's dental arch to form the customizable tray. Multiple active ingredients may be used, with or without peroxide, for accomplishing desired treatment regimens.

Abstract: A syringe for dispensing a flowable material. The syringe has a cartridge with a cartridge front end and at least a first dispensing nozzle arranged at the cartridge front end. The syringe further has closure for openably closing the first dispensing nozzle. The closure includes a cap and at least a first seal. The cap is telescopically placeable on the cartridge front end. The closure or the cartridge has a first magnet for establishing a magnetic attraction between the closure and the cartridge. In a situation in which the closure is placed on the cartridge front end, the closure and the cartridge can be positioned in a sealing position in which the first seal spaces the cap and the cartridge front end away from each other against a magnetic attraction that urges the cap and the cartridge toward each other.

Abstract: A hypochlorous acid disinfectant and its production method. The disinfectant is prepared by weight in a total of 100% as chlorine powder (chlorine compounds including sodium hypochlorite or calcium hypochlorite) of 20 to 45%, adding sodium dihydrogen phosphate or citric acid, or ingredients or raw materials with acidic pH of 15 to 40% as a main ingredient, a desiccant of 15 to 20%, excipients of 3 to 8%. The method includes: stirring the chlorine powder with the desiccant; adding the sodium dihydrogen phosphate, the citric acid, or the ingredients or raw materials with acidic pH in order; and adding the excipient while stirring for 20 to 30 minutes until completely uniform to prepare the hypochlorous acid (powder) disinfectant. According to the method, a hypochlorous acid tablet disinfectant can be prepared.

Abstract: In certain embodiments a dental strip for the prevention or reduction of dental caries is provided. In certain embodiments the dental strip is constructed to deliver effective amounts of specifically targeted antimicrobial peptides (or simple antimicrobial peptides) and comprises an orally compatible backing layer, a delivery layer disposed on one surface of the backing layer where the delivery layer comprises an orally compatible polymer, or combination of polymers, and a specifically targeted antimicrobial peptide (and/or simple antimicrobial peptide) capable of binding and killing Streptococcus mutans. In certain embodiments the dental strip additionally comprises a release liner.

Abstract: A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.

Abstract: Disclosed herein are oral care compositions comprising a peroxide whitening complex in an amount to provide from 3.5% to 7% of hydrogen peroxide by weight of the composition, and a block copolymer of ethylene oxide and propylene oxide in an amount of from 40% to 60% by weight of the composition. Methods of making and using the dentifrices are also provided.

Abstract: Disclosed herein are embodiments of therapeutic substances that contain solid sodium percarbonate for use in a bath, and packaging for the therapeutic substances. The solid sodium percarbonate can be dissolved in a liquid, such as water, to produce a hydrogen peroxide solution. Hydrogen peroxide solutions can be provide beneficial effects to a user. The titrated sodium percarbonate can be mixed with other chemicals/materials in a pre-made packaging for ease of storage and using with a bath.

Abstract: The present invention provides a patch for attaching to teeth or a surrounding part of teeth, and the patch can be easily removed by tooth brushing alone.

Abstract: A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.

Abstract: A loxapine film oral dosage form includes loxapine salt, free base, or prodrug in an amount effective to provide relief from acute agitation associated with schizophrenia or bipolar 1 disorder via oral transmucosal delivery, dispersed in a polymeric film forming system. Advantageously, the film oral dosage form further includes a sweetener, a refreshing agent, an antioxidant, a pH stabilizer, a penetration enhancer, a mucoadhesive agent and a plasticizer. The loxapine film oral dosage form provides rapid onset of relief from acute agitation associated with schizophrenia or bipolar 1 disorder without presenting pulmonary health risks, thereby reducing risks to patients and others.

Abstract: The present invention provides a composition and method for preventing or healing injured nipples or areolas in mammalian females utilizing components of water, peppermint oil and poloxamer in a synergistic ratio.

Abstract: Multi-phase oral care compositions for whitening teeth including hydrophilic bleaching agent particles in a hydrophobic phase with a cone penetration consistency value of from about 25 to about 300. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.

Abstract: The present invention relates to oral composition and the method of preparation and use of such composition for inhibiting, reducing, and/or disrupting oral biofilm. The composition comprises a stabilizing matrix, a cationic biocide, and a peroxide source.

Abstract: The present disclosure provides an oral care composition including a water-miscible base component, an amorphous calcium phosphate remineralizing component including a water-soluble or partially water-soluble calcium component and a water-soluble inorganic phosphate component, and a tartar control component, wherein the oral care composition provides enamel fluoride uptake activity and tartar control activity.

Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.

Abstract: Methods and kits for removing calculus from a tooth, wherein the method can include applying a component A to the tooth, wherein component A comprises a hydrogen peroxide or a precursor thereto; applying a component B to the tooth, wherein component B comprises a non-enzymatic, hydrogen peroxide decomposition catalyst for generating oxygen gas; wherein components A and B are applied simultaneously or sequentially to the tooth, thereby generating oxygen gas to soften and/or loosen at least part of the calculus on the tooth; and removing at least a part of the calculus from the tooth.

Abstract: Semisolid oral dispersions for whitening teeth including hydrogen peroxide adducts in petrolatum. The hydrogen peroxide adduct can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. The semisolid oral dispersion and/or the petrolatum can have a cone penetration consistency value of from about 25 to about 300.

Abstract: Described herein are complexes comprising a cationic antibacterial agent and a metal salt; oral care compositions comprising same; along with methods of making and using these complexes and compositions.

Abstract: A bacteria removal laser is provided, especially for removing caries bacteria from natural or prosthetic teeth, the prosthetic teeth also being treated via extraoral approach, having a gripping handle, a laser radiation source, an application optics having a predetermined radiation exit surface, especially a radiation guide rod through which laser radiation passes, and an energy source such as a mains connection or an accumulator. The laser emits in the wavelength range between 2200 nm and 4000 nm and is especially designed as an Er:YAG laser. The energy output averaged over time is less than 1 mJ/mm2 at the radiation exit surface.

Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

Abstract: A tooth paste composition comprising black cumin oil (Nigella sativa) and fluoride-doped bioactive glass, zinc oxide, and/or titanium oxide is disclosed.

Abstract: The present invention is a formable dental treatment tray utilizing poly(2-ethyl-2-oxazoline) and a gelatinous active. Blending of the active is accomplished by mixing the Poly(2-ethyl-2-oxazoline) with an active ingredient, such as a peroxide like hydrogen peroxide, carbamide peroxide, sodium perborate, or sodium percarbonate, usually also with water or an appropriate organic solvent. Peroxide concentrations in these new gels can reach a 30% concentration of hydrogen peroxide while maintaining a shelf life of six months at room temperature without developing peroxide decomposition. The gels are applied to an appropriate backing and dried to a gelatinous state. In use, the active is hydrated and regains adhesiveness. Then the tray is pressed and formed around a user's dental arch to form the customizable tray. Multiple active ingredients may be used, with or without peroxide, for accomplishing desired treatment regimens.

Abstract: Disclosed is method, a user interface, a computer program product and a system for predicting future development of a dental condition of a patient's set of teeth, wherein the method comprises: —obtaining two or more digital 3D representations for the teeth recorded at different points in time; —deriving based on the obtained digital 3D representations a formula expressing the development of the dental condition in terms of at least one parameter as a function of time; and—predicting the future development of the condition based on the derived formula.

Abstract: Methods for treating and/or preventing periodontal disease with arginine silicate are disclosed. Methods may include the steps of identifying an individual in need of treatment for, or in need of prevention of, periodontal disease and administering an effective amount of an arginine-silicate complex to said individual. Arginine silicate may also be used to ameliorate one or more symptoms of periodontal disease. In some aspects, arginine silicate may be used to restore gum health and/or stop or reverse recession of the gums and/or the loss of gum tissue in the oral cavity.

Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

Abstract: A multi-phase oral composition for whitening teeth.

Abstract: An oral care implement herein may be embodied as an oral device for placement in the oral cavity. The device may include an insert configured for placement in the oral cavity in contact with a wearer's teeth and an activating member configured for placement in the oral cavity and selectively attachable to the insert.

Abstract: An oral care composition, including a non-aqueous dispersant and a fatty acid structure-building agent.

Abstract: Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.

Abstract: An oral care composition, including a non-aqueous dispersant and an amphiphilic copolymer structure-building agent.

Abstract: Provided herein is a liquid, nonaqueous composition including a pesticide in form of suspended particles, a water soluble solvent, an inorganic thickener, and an alkoxylate. Further provided herein is a method for the preparation of the composition, wherein the pesticide, the water soluble solvent, the inorganic thickener, and the alkoxylate are contacted. Additionally provided herein is a method for controlling phytopathogenic fungi, undesired plant growth, and/or undesired attack by insects or mites, and/or for regulating the growth of plants, wherein the composition acts on the particular pests, their habitat, the plants to be protected from the particular pest, the soil, the undesired plants, the useful plants, and/or the habitat of each plant.

Abstract: A tooth whitening method uses an application device having a reservoir containing an oxidizing composition comprising a fluid carrier and an oxidizing agent, an applicator member in fluid communication with the reservoir, and a dispensing mechanism for moving contents of the reservoir into the applicator member. The oxidizing composition is dispensed into the applicator member by actuating the dispensing mechanism and is applied to one or more teeth in an oral cavity. Then, a sealant composition is applied to the teeth having the oxidizing agent thereon to form a coating that resists moisture contamination of the previously applied oxidizing agent. One embodiment uses an oxidizing composition with a viscosity less than 150 cps that is absorbed in a porous material in the device reservoir, from which it is introduced by capillary action into a porous applicator member.

Abstract: Disclosed are oral care compositions which provide faster and enhanced whitening efficacy. The present compositions comprise a unique combination of whitening agent, gum soother and sodium benzoate.

Abstract: The present invention relates to an aqueous oxidizing composition comprising one or more oxidizing agent, one or more sugar and/or one or more polyethylene glycol and having a pH in the range of 1 to 5.

Abstract: Disclosed herein are non-aqueous dentifrice compositions comprising (i) a whitening complex comprising crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide; (ii) an off-gas reducing agent selected from sodium sulfate, magnesium sulfate, citric acid and clay; and (iii) an orally acceptable carrier. Methods of making and using the compositions are also provided.

Abstract: The present invention provides a patch for attaching to teeth or a surrounding part of teeth, and the patch can be easily removed by tooth brushing alone.

Abstract: Oral care compositions and methods for whitening teeth are provided. The oral care composition may include an orally acceptable vehicle, a whitening booster, and a source of hydrogen peroxide. The whitening booster may be dispersed in the orally acceptable vehicle. The whitening booster may include a salt of a monopersulfate, such as an alkali metal salt of the monopersulfate.

Abstract: An oral care composition, including a peroxysulfate whitening agent, a non-aqueous dispersant having a non-aqueous liquid, and a structural builder.

Abstract: Described herein are oral care whitening compositions comprising a non-aqueous phase comprising a peroxysulfate whitening agent, a hydrophobic base and at least one hydrophilic polymer, and optionally an aqueous phase comprising at least one hydrophilic polymer. Methods of making and using these compositions are also described herein.

Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

Abstract: The present invention provides an oral care system comprising (a) a first composition comprising: (i) a peroxide-containing whitening agent; and (ii) at least one silicone polymer, and (b) a second composition comprising a polymer selected from polysaccharides, acrylate polymers, acrylamide polymers, and a mixture of any two or more thereof; wherein the first composition and the second composition are maintained separately from one another. The present invention also provides a method of whitening teeth using the oral care system.

Abstract: An oral varnish comprising a combination of two different viscosity dimethicone components, wherein the difference between the two different viscosity dimethicone components is about 2.0 million cP or greater; and comprising at least one active ingredient, which is preferably a fluoride donor.

Abstract: The present invention provides an oral care composition comprising from 3 to 12 weight % calcium pyrophosphate and from 10 to 19 weight % precipitated silica, based on the total weight of the composition, wherein the precipitated silica has a pellicle cleaning ratio of greater than 85. The present invention further provides a method of cleaning and/or polishing and/or whitening an oral surface comprising contacting the oral surface with the oral care composition.

Abstract: A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or remineralisation.

Abstract: The present invention relates to a tooth-attachable patch comprising: a drug layer for delivering drugs to a tooth; and a backing layer positioned on the opposite side of a tooth attachment surface of the drug layer, and including, both a water-soluble polymer and a water-insoluble polymer. The patch of the present invention can be easily removed by merely brushing the teeth without separately stripping off a backing layer.