Body Fluid Or Exudate Or Transudate Other Than Snake Venom, Feces, Urine, Or Semen (e.g., Lymph, Saliva, Honey, Royal Jelly, Digestive Juice, Etc.) Patents (Class 424/537)
  • Patent number: 10624927
    Abstract: A pharmaceutical composition includes an effective amount of a bio-active fraction or subfraction of lyophilized camel urine. The composition is used as an anti-cancer drug which selectively targets the cancer cells without affecting the normal cells.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: April 21, 2020
    Inventor: Fatin A. Khorshid
  • Patent number: 10561689
    Abstract: A method of treating damaged nerves can include administering a therapeutically effective amount of a composition comprising a soluble protein fraction obtained by fractionating epidermal gel secretions of catfish to a patient in need thereof. The soluble protein fraction can include about 87% soluble proteins and about 13% lipids. The composition can be administered by intraperitoneal (IP) or sub-cutaneous (SC) injection.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: February 18, 2020
    Inventors: Jassim M. Hassan M. Ali, Waleed Renno
  • Patent number: 10537594
    Abstract: The present disclosure relates to, inter alia, compositions and kits comprising an asialoglycoprotein covalently attached to a polycation, and functional mammalian mitochondria that are at least partially purified and are electrostatically bound to the AsG-polycation molecule; as well as methods of their preparation and use.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: January 21, 2020
    Assignee: University of Connecticut
    Inventors: George Y Wu, Catherine H Wu, Nidhi Gupta
  • Patent number: 10471105
    Abstract: A method of treating infertility in males can include administering a therapeutically effective amount of a composition comprising a soluble protein fraction obtained by fractionating epidermal gel secretions of catfish to a patient in need thereof. The soluble protein fraction can include soluble proteins and lipids obtained by fractionating the epidermal gel secretions of catfish. The soluble protein fraction can include 87% soluble proteins and 13% lipids. The composition can be administered by intraperitoneal (IP) or sub-cutaneous (SC) injection or sublingual (SL). A method of preparing the soluble protein fraction can include collecting the epidermal gel secretion of catfish and preparing a soluble protein fraction having 87% soluble proteins and 13% lipids by weight.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: November 12, 2019
    Inventors: Jassim M. Hassan M. Ali, Waleed M. Renno
  • Patent number: 10098857
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1? in the wound.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: October 16, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
  • Patent number: 10016466
    Abstract: A composition and method for treating Epidermolisis bullosa (EB), comprising: applying to skin or mucosal surfaces of a patient in need of treatment for EB a dressing gauze or bandage without prior cleaning of said skin or mucosal surfaces, wherein distributed on said dressing is an effective amount of a composition containing beeswax; an oleaginous base, vitamins and a pharmaceutically acceptable excipient; then removing said dressing at least twice per day without damaging the patient's skin or mucosal surfaces due to removal of the dressing.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: July 10, 2018
    Assignee: REV PHARMA CORP
    Inventor: Ramon Efrain Vasquez
  • Patent number: 9994915
    Abstract: Provided herein are methods for the diagnosis of human melanoma by assessing MITF, miR-211, TRPM1, and/or KCNMA1 and methods for the diagnosis of resistance to chemotherapeutic agents by assessing the regulatory pathways of PGC1?. Methods for treating melanoma, including drug-resistant melanoma, are also provided.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 12, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventor: Ranjan Perera
  • Patent number: 9730865
    Abstract: The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery method or composition, and use in nursing lubrication.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: August 15, 2017
    Assignees: Lubris, LLC, Schepens Eye Research Institute
    Inventors: Benjamin Sullivan, Edward R. Truitt, David Sullivan
  • Patent number: 9345720
    Abstract: Provided, among other things, is a method of treating a wound comprising: periodically applying to the wound over a course of days an effective amount of a water based formulation (comprising: 0.5 to 5 wt % of an emollient comprising silicone oil, 2 to 10 wt % of fatty acid, humectant(s), emulsifying agent(s), and polymer(s)), wherein the formulation is formulated as a spray, cream, lotion, milk or foam-former.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: May 24, 2016
    Assignee: Exeltis USA Dermatology, Inc.
    Inventors: Christopher N. Hensby, Mats Silvander
  • Patent number: 9233129
    Abstract: Disclosed is a method for the purification of bee venom on a mass scale. It comprises dissolving crude bee venom in a solvent to form a bee venom solution; applying an adsorbent to the bee venom solution to form a mixture; and removing the adsorbent through filtration to afford a pure bee venom solution. By the method of the present invention, crude bee venom collected from bee farms can be purified to a purity of 99% or higher on a mass scale, without inducing a change in the composition thereof, and thus the purified bee venom can be used as a material for medicines, cosmetics and foods.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 12, 2016
    Assignee: Republic of Korea (Management: Rural Development Administration)
    Inventors: Sang Mi Han, Kwang Gill Lee, Kwan Kyu Park
  • Patent number: 9198897
    Abstract: The invention provides methods and compositions comprising an anti-cholinergic agent for decreasing saliva production and treating sialorrhea.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: December 1, 2015
    Assignee: NeuroHealing Pharmaceuticals, Inc.
    Inventors: Marcelo Merello, Neal M. Farber, Eyal S. Ron
  • Patent number: 9017732
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: April 28, 2015
    Assignee: Biopep Solutions, Inc.
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Publication number: 20150110888
    Abstract: The present invention relates to compositions comprising substances of natural origin for use in the treatment or preventing the onset or the aggravation of diabetic foot ulcers.
    Type: Application
    Filed: April 23, 2013
    Publication date: April 23, 2015
    Applicant: ABOCA S.P.A. SOCIETA AGRICOLA
    Inventors: Valentino Mercati, Anna Maidecchi
  • Patent number: 9005667
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: April 14, 2015
    Assignee: Biopep Solutions Inc
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Publication number: 20150099006
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 9, 2015
    Inventors: Abbas Mohammad GHAWI, Ahmed MERZOUK, Abdualrahman ABDUALKADER, Mohamed ALAAMA
  • Patent number: 8992995
    Abstract: An improved topical cosmetic skin formulation is provided. The inventive formulation includes leaf lard as a base, zinc oxide and beeswax. In addition, slippery elm bark may be added to the formulation. Further, benzoin styrax may be added to the inventive formulation.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: March 31, 2015
    Assignee: Bay Song Art, Inc.
    Inventor: Donna Penney
  • Publication number: 20150086625
    Abstract: Activated fatty acids, nutraceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: December 8, 2014
    Publication date: March 26, 2015
    Inventor: Raymond A. Miller
  • Publication number: 20150086645
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 26, 2015
    Inventors: ABBAS MOHAMMAD GHAWI, AHMED MERZOUK, ABDUALRAHMAN ABDUALKADER, MOHAMED ALAAMA
  • Publication number: 20150079196
    Abstract: A wound dressing makes use of polysaccharides, including the formation of a range of variable viscosity mixtures that use a solid polysaccharide such as medical grade cane sugar and a liquid polysaccharide such as honey, both of which have inherent beneficial properties for wound healing. The mixture is applied to an absorbent surface that is designed to absorb the mixed polysaccharide only partially.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 19, 2015
    Applicant: MEDLINE INDUSTRIES, INC.
    Inventors: Debashish Chakravarthy, Andrew J. Ford
  • Publication number: 20150079192
    Abstract: The present invention relates to the treatment of cancers. Specifically, the invention pertains to a method for the extracorporeal treatment of one or more body fluids (e.g., blood or cerebrospinal fluid, CSF) in two stages characterized by removing a body fluid (e.g., blood or CSF) from a living body diseased with a type of cancer, passing the body fluid through a first stage of applying a treatment to at least one antigen in the body fluid. More specifically, the treatment comprises creating an antibody-antigen moiety during passage thereof through said first stage, passing the treated body fluid through a second stage, removing antibody-antigen moiety from the body fluid during passage through the second stage, and returning the purified body fluid to the body.
    Type: Application
    Filed: May 21, 2013
    Publication date: March 19, 2015
    Inventor: Mitchell S. Felder
  • Patent number: 8962034
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: February 24, 2015
    Assignee: Biopep Solutions, Inc.
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Publication number: 20150030688
    Abstract: Tissue engineering structures with biologically favorable structural and chemical properties are disclosed. More particularly, the present disclosure is directed to tissue engineered scaffolds having a fiber support and honey. The tissue engineered scaffolds having a fiber support and honey can further include at least one biomolecule. The tissue engineered scaffolds can be used to promote cellular chemotaxis, enhance cell proliferation, enhance extracellular matrix production, increase angiogenesis, and provide antimicrobial activity. The nature of the tissue engineered scaffolds provides a template for cellular infiltration and guide tissue regeneration. The tissue engineered scaffolds can be used in the treatment of dermal wounds (burns, chronic wounds, etc.) or as a tissue engineering scaffold in a wide range of applications.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 29, 2015
    Inventors: Scott Allen Sell, Benjamin Alexander Minden-Birkenmaier
  • Patent number: 8932642
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: January 13, 2015
    Assignee: Biopep Solutions, Inc.
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Publication number: 20140377371
    Abstract: A composition for Urinary Incontinence treatment comprising one active ingredient wherein the at least one active ingredient is derived from a natural source, in combination with at least one other active ingredient; wherein the at least one other active ingredient is derived from a natural, artificial or semi-artificial source; and electively at least one excipient.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 25, 2014
    Inventor: Uchechi L. Eze
  • Publication number: 20140363518
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 11, 2014
    Applicant: Biopep Solutions, Inc.
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Publication number: 20140356448
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 4, 2014
    Applicant: Biopep Solutions, Inc.
    Inventors: ABBAS MOHAMMAD GHAWI, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Publication number: 20140348877
    Abstract: The invention is crustacean hemolymph as a utility for the pharmaceutical and/or cosmetic treatment of viral and other neoplastic or pre-neoplastic mammalian tissue lesions. The method comprises topically administering to mammalian tissue a formula that is made from lobster hemolymph—neat; or lobster hemolymph extracts; or lobster hemolyph in combination with certain carriers, binders; or as an adjuvant. The hemolymph may be from various species of lobster, Homarus americanus in particular.
    Type: Application
    Filed: February 16, 2013
    Publication date: November 27, 2014
    Inventor: Robert C. Bayer
  • Publication number: 20140348899
    Abstract: A medicament for treating cystitis and a method of treatment are provided. The medicament comprises a stromal vascular fraction provided in a liposomal carrier. Optionally, the medicament also controls one or more additional agents, such as a growth factor, glycosaminoglycan, DMSO, and/or another small molecule used to treat cystitis or having an effect on human stem cells. Cystitis is treated by intravesically administering to a patient a therapeutically effective dose of the medicament. The SVF can be derived from a patient's own adipose cells via liposuction.
    Type: Application
    Filed: May 22, 2013
    Publication date: November 27, 2014
    Applicant: Nanologix Research, LLC
    Inventors: Elliot B. Lander, Jackie R. See
  • Publication number: 20140302156
    Abstract: The invention concerns a rigid shaped article essentially consisting of a plurality of mutually adhering grains of sand provided with a coating consisting of wax, for the elimination or relief of itching. In a particular embodiment of the invention, the wax essentially consists of beeswax.
    Type: Application
    Filed: August 25, 2011
    Publication date: October 9, 2014
    Inventor: Norbert Beermann
  • Patent number: 8834936
    Abstract: A skin care composition comprising an isolated Asteroidea body fluid or extract thereof is described. Uses and methods of use of the composition for the prevention and/or treatment of a skin disorder or condition, such as skin-aging signs, are also described.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: September 16, 2014
    Assignee: Innovactiv Inc.
    Inventors: Martin Beaulieu, Estelle Loing, Catherine Fillion, Patrice Dionne, Alain Lavoie, Alain Thibodeau
  • Publication number: 20140234378
    Abstract: The invention is crustacean hemolymph as a utility for the pharmaceutical and/or cosmetic treatment of viral and other neoplastic or pre-neoplastic mammalian tissue lesions. The method comprises topically administering to mammalian tissue a formula that is made from lobster hemolymph—neat; or lobster hemolymph extracts; or lobster hemolyph in combination with certain carriers, binders; or as an adjuvant. The hemolymph may be from various species of lobster, Homarus americanus in particular.
    Type: Application
    Filed: February 16, 2013
    Publication date: August 21, 2014
    Inventor: Robert C. Bayer
  • Publication number: 20140227204
    Abstract: Skin compositions comprising, hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and related method for protecting, healing and/or soothing the skin comprising: applying an effective amount of a cosmetic preparation selected from the group consisting of hand cream, foot cream, body cream, lip cream, lip gloss, lip stick, gel, balm and lotion to the skin surface; wherein said cosmetic preparation includes a skin composition made of hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and said effective amount is enough to protect, heal and/or soothe the skin surface.
    Type: Application
    Filed: February 11, 2013
    Publication date: August 14, 2014
    Inventor: Norman Turkowitz
  • Publication number: 20140220150
    Abstract: The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and their mixtures, to provide an armamentarium of defenses from multiple stressors in order to help bees survive and more particularly overcome a complex of symptoms collectively called colony collapse disorder (CCD). The methods and compositions of this designed fungal bioshield helps tilt the balance in favor of bee colony survival, improving the health conditions, disease resistance, pesticide tolerance, pollution tolerance, drought tolerance, pollination abilities, and quality of the honey produced by bees.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Inventor: Paul Edward Stamets
  • Publication number: 20140212506
    Abstract: This invention relates to use of manuka honey in the treatment of cancer. The invention is also directed to the combination of manuka honey with other chemotherapeutic agents to reduce the toxicity of the treatment.
    Type: Application
    Filed: October 1, 2013
    Publication date: July 31, 2014
    Applicant: UNITED ARAB EMIRATES UNIVERSITY
    Inventors: Basel Al-Ramadi, Hakam El-Taji, Maria J. Fernandez-Cabezudo, Fawaz Torab
  • Patent number: 8790711
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 29, 2014
    Assignee: Biopep Solutions, Inc.
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohamed Alaama
  • Patent number: 8784896
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 22, 2014
    Assignee: Biopep Solutions, Inc
    Inventors: Abbas Mohammad Ghawi, Ahmed Merzouk, Abdualrahman Abdualkader, Mohammad Alaama
  • Patent number: 8784873
    Abstract: The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: July 22, 2014
    Assignee: Naturewise Biotech & Medicals Corporation
    Inventors: Chung-Yang Huang, Chia-Nan Chen, Wei-Jung Chen, Wei-Jan Huang, Li-Ling Chi
  • Publication number: 20140199266
    Abstract: Novel nasal rinse compositions are disclosed. The nasal rinse comprises a dried particulate composed of honey and a carrier. The composition may be a co-processed composition wherein the honey and carrier are combined while the honey is in liquid form and processed together to produce the dried particulate. Methods for producing the nasal rinse compositions are also provided, as well as methods of use of the nasal rinse compositions for the prevention or treatment of nasal infection, rhinitis, or sinusitis.
    Type: Application
    Filed: January 14, 2014
    Publication date: July 17, 2014
    Applicant: LOST CREEK CONSULTING, LLC
    Inventors: Roland Clifford Park, Kenneth Gene Rayl, Ian Joseph Alexander
  • Publication number: 20140193513
    Abstract: Disclosed is a method in which poloxamer, a resin, and/or a tocopherol is/are fused, and the material that is to be treated is intimately dispersed with said melt. After being introduced into the melt, the material that is to be treated is coated with water to prevent hardening, and the spontaneously forming gel is homogenized. The obtained product is composed of a transparent gel that is based on at least one poloxamer, a resin or a tocopherol, and an active substance which is solubilized, dispersed, and stabilized therein and whose consistency ranges from solid, semisolid, i.e. aspic-like, to liquid. The micelles of said solubilized matter remain stable even when the same is diluted well below the CMC of poloxamer.
    Type: Application
    Filed: February 19, 2014
    Publication date: July 10, 2014
    Applicant: BIOREM AG
    Inventor: Hanspeter Strobel
  • Publication number: 20140193514
    Abstract: The invention describes a method to treat an extracorporeally body fluid. The body fluid can include, for example, blood, cerebral spinal fluid and lymph. A first stage of the method applies a treatment to the extracorporeal body fluid. The treatment comprises combining at least one antibody with a CA antigen to produce an antibody-CA antigen moiety. A second stage of the method substantially removes the antibody-CA antigen moiety from the extracorporeal body fluid.
    Type: Application
    Filed: August 16, 2012
    Publication date: July 10, 2014
    Applicant: MARV ENTERPRISES
    Inventor: Mitchell S. Felder
  • Publication number: 20140186457
    Abstract: The present invention relates to compositions includes honey and L-alanyl-L-glutamine, pharmaceutical compositions thereof and a combined product comprising honey and L-alanyl-L-glutamine for a simultaneous, separate or sequential use in therapy. The composition, pharmaceutical composition and combined product have particular utility in improving sleep and treating sleep disorders such as insomnia or sleep apnoea.
    Type: Application
    Filed: May 16, 2012
    Publication date: July 3, 2014
    Applicant: HIBERNATION HONEY LIMITED
    Inventor: Mike McInnes
  • Publication number: 20140154333
    Abstract: The present invention relates to medicinal compositions containing a honey having non peroxide antibacterial activity and wherein the composition comprises from about 19% to about 80% water by weight. The use of these compositions in the treatment of eye, respiratory and ear conditions is also disclosed.
    Type: Application
    Filed: October 28, 2013
    Publication date: June 5, 2014
    Applicant: MEDIHONEY PTY LTD.
    Inventor: Anthony Peter Moloney
  • Publication number: 20140147471
    Abstract: Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type II arabinogalactan compounds and utilising this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 29, 2014
    Applicant: COMVITA NEW ZEALAND LTD.
    Inventors: Ian Sims, Jonathan McDonald Counsell Stephens, Ralf Christian Schlothauer, Swapna Gannabathula
  • Patent number: 8734860
    Abstract: This invention is disclosing a pure ointment of traditional Chinese medicine which was invented to treat burn or scald, and infectious trauma, and its preparation. The ointment has solved a number of problems in the treatment of burn or scald, and infectious trauma, such as the high cost of current drugs, post-treatment scar, and unfavorable therapeutic effect. The advantages of this ointment include low cost, favorable therapeutic effect, short course, and without scar after treatment. Its formula is based on the weight of every five hundred portions of following ingredients: lithospermum, 4-10 portions, beeswax, 5-20 potions, insect-white wax, 5-20 portions, and lard, 450-486 portions.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: May 27, 2014
    Inventor: Xinwei Sun
  • Publication number: 20140127283
    Abstract: A composition comprising honey and a super-absorbent material. A method of treating a lesion comprising applying a composition comprising honey and a super-absorbent material to the lesion. A method of manufacturing the composition of the invention, comprising: (a) providing at least one type of honey; (b) providing at least one super-absorbent material; and (c) combining the honey and super-absorbent material.
    Type: Application
    Filed: September 12, 2013
    Publication date: May 8, 2014
    Applicant: ManukaMed Limited
    Inventor: Denis Eric WATSON
  • Publication number: 20140120174
    Abstract: Provided are methods of diagnosing sepsis in a patient by detecting the presence and/or amount of at least two biomarkers of sepsis or severe sepsis/septic shock in a sample from the patient. The methods and biomarkers may be used to develop an accurate prognosis for a patient having sepsis or severe sepsis/septic shock or suspected of having sepsis or severe sepsis/septic shock, or to accurately diagnose a patient having, or suspected of having sepsis or severe sepsis/septic shock. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for a sepsis therapy.
    Type: Application
    Filed: October 30, 2013
    Publication date: May 1, 2014
    Inventors: Stuart Blincko, Ingo Curdt, Mario Berger, Martin John Llewelyn
  • Publication number: 20140112997
    Abstract: The present disclosure relates to a honey product having a low water content. The honey product retains the physical and palatable properties of untreated honey while having a prolonged shelf-life. It can be advantageously used to sweeten beverages (such as hot beverages) and in the manufacture of throat lozenges and/or confectionery.
    Type: Application
    Filed: November 15, 2013
    Publication date: April 24, 2014
    Applicant: IAF SCIENCE HOLDINGS LTD.
    Inventor: John Lawrence Rowe
  • Patent number: 8703205
    Abstract: Compositions comprising honey, myrrh, and Nigella Sativa seeds are described. The honey:myrrh:N. sativa seed ratio can be 100:0.5-50:0.1-10, based on weight. The compositions can also comprise one or more pharmaceutically acceptable diluents and/or excipients. Also described herein are methods for treating a wound comprising administering to the wound an effective amount of the present composition. The wound can be a bed sore or a diabetic ulcer. The wound can also be infected.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: April 22, 2014
    Inventors: Hasan Ali Alzahrani, Balkees Abed Bakhotmah
  • Patent number: 8685462
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: April 1, 2014
    Assignee: Biopep Solutions, Inc.
    Inventors: Ahmed Merzouk, Abbas Mohammad Ghawi, Abdualrahman M. Abdualkader, Mohamed Alaama
  • Publication number: 20140079799
    Abstract: Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about ?20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
    Type: Application
    Filed: September 21, 2012
    Publication date: March 20, 2014
    Applicant: Biopep Solutions, Inc.
    Inventors: Abbas Mohammed GHAWI, Ahmed MERZOUK, Abdualrahaman ABDUALKADER, Mohammad ALAAMA