Extract, Body Fluid, Or Cellular Material Of Undetermined Constitution Derived From Animal Is Active Ingredient Patents (Class 424/520)
  • Patent number: 11191780
    Abstract: The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: December 7, 2021
    Assignee: Adaptive Biologix, Inc.
    Inventors: Gail K. Naughton, Frank Zeigler, Emmett Pinney
  • Patent number: 11134712
    Abstract: An adjustable breading machine for applying a coating material onto a food product, the machine includes a frame and a breading chamber enclosure through which the food product travels along the food path to receive a coating material. The adjustable breading machine may also include a hopper fixedly connected to the frame to deliver a coating material into the breading chamber enclosure. At least partially within the breading chamber enclosure is a main conveyor and an outfeed conveyor. In a first mode of operation, the outfeed conveyor lies in the food path and receives food product from the main conveyor. The adjustable breading machine includes a drum assembly operatively disposed above the outfeed conveyor having a rotatable drum for transporting food product and coating material to the outfeed conveyor. The adjustable breading machine also includes a drum adjustment assembly for moving the drum assembly between modes of operation.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: October 5, 2021
    Assignee: MP EQUIPMENT LLC
    Inventors: Rodney Nelson, Matt Palmer, Antonio Munoz, Brian Hopper
  • Patent number: 11090313
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: August 17, 2021
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Patent number: 11077152
    Abstract: Provided are: a method for producing a nasal drop composition suitable for treatment or prevention of a disease or symptom in the nasal cavities; and a nasal drop composition produced by the production method. The nasal drop composition production method characterized by including a mixing step of mixing earthworm castings with water and a collecting step of collecting vaporized water generated from a mixture obtained in the mixing step to obtain a liquid; and the nasal drop composition produced by the production method. It is preferred to further mix an organic substance together with the earthworm castings and the water in the mixing step.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: August 3, 2021
    Assignee: WELL STONE CO.
    Inventors: Yoichi Ishii, Takeshi Okamoto, Sayaka Makino
  • Patent number: 11071763
    Abstract: An herbal extract and constituents thereof for treatment of BPH and related aging symptoms in males and for addressing male health using extracts from Ageratum spp., including, but not limited to, Ageratum conyzoides, Ageratum coeruleum and Ageratum houstonianum, is disclosed herein. At least one compound of plants, and parts of plants, of Ageratum spp., such as, but not limited to, N,N-bis(trimethylsilyl)-2-phenyl-7-(trifluoromethyl)quinolon-4-amine, 3?,4?,5?,6?,7?,8-hexamethoxyflavone, Phytol, Precocene, caryophyllene, squalene, alpha-linolenic acid, (Z,Z)-9,12-octadecadienoic acid, Hexadecanoic acid, Hydrocoumarin, Encecaline-1-(7-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone, Senensetin-3,4,5,6,7-pentamethoxy flavone, Beta selinene, Stigmasterol, Beta sitosterol, Quercetin, Quercetin-3-O-rhamnosylglucoside, Linoleic acid, or Conyzorigin can be extracted utilizing a Common Plant Extraction Approach (CPEA).
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: July 27, 2021
    Assignee: GE Nutrients, Inc.
    Inventors: V. T. Jagannathan, Ramasamy Varadarajan Venkatesh, Jith Veeravalli
  • Patent number: 11006619
    Abstract: An aquatic biofiltration system where invertebrate aquatic filtering organisms in the form of tunicates filter free-floating particulates in a water volume is disclosed. The system provides a habitat for tunicates with at least one residence device (5, 6) adapted to be arranged in a water volume, and a collection system (7) adapted to collect expelled solids from the tunicates. A biofiltration method for filtering particulates from a volume of water is also disclosed.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: May 18, 2021
    Inventor: Hans Gude Gudesen
  • Patent number: 10973228
    Abstract: [Problem] The object is to obtain cosmetics which do not show primary skin irritation or sensitization, and do not impart any unpleasant sensation such as sharp pain or prickly sensation when employed as a cosmetic, with the lowest possible inclusion of preservative/fungicide. [Solution] Antimicrobial low-irritant cosmetics characterized in that they contain one or two or more tropolone derivative(s) and one or two or more polyhydric alcohol(s) in quantities which have an anti-microbial effect and low skin irritancy.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: April 13, 2021
    Assignee: ISP INVESTMENTS LLC
    Inventors: Nadia Konate, Andrea Wingenfeld
  • Patent number: 10898611
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: January 26, 2021
    Assignee: NuVasive, Inc.
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
  • Patent number: 10874705
    Abstract: The present invention relates to extracts, compounds isolated from Cakile arabica for use in the treatment of ulcer and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: December 29, 2020
    Inventors: Awaad Amani Shafeek, Reham Moustafa El-Meligy, Mohammed Sobhy Marzouk, Shroog Mohamed Alotaiby
  • Patent number: 10835576
    Abstract: Embodiments of the present invention are generally related to methods of obtaining effective amount of avian follistatin. More specifically, embodiments of the present invention relate to products comprising avian follistatin, and methods of optimizing the same based on avian follistatin concentrations utilized during the manufacturing process. In one embodiment of the present invention, a method of creating a consumable product for treatment of a muscle degenerating disease having avian follistatin comprises selecting an avian egg based upon a desired threshold of avian follistatin concentration therein; extracting material from the avian egg, the material comprising avian follistatin; and processing the material with one or more excipients to yield the consumable product.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: November 17, 2020
    Assignee: MYOS RENS TECHNOLOGY INC.
    Inventors: Neerav Padliya, Robert J. Hariri, Carlon Colker
  • Patent number: 10718032
    Abstract: Novel time and temperature integrator (TTI) assays, kits containing the components of the assays, and the novel components for those assays are provided herein. These novel TTI assays evaluate and/or determine the inactivation of biological material in/on a sample by quantifying the degradation of DNA using qPCR. The sample can be a food product (e.g., fruits, vegetables, meat from animals, or eggs) while the item can be any object (e.g., medical equipment, especially reusable medical equipment) for which one needs to determine that the amount of inactivation of specific hazardous biological material on the object or in a sample is at or below a pre-determined amount.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: July 21, 2020
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Ilenys M. Perez Diaz, Jane M. Caldwell
  • Patent number: 10668087
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 2, 2020
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Patent number: 10568915
    Abstract: A method of preparing a therapeutic composition from the epidermal gelatinous secretion of catfish includes mixing catfish epidermal gel secretions (EGS) with phosphate buffered saline (pH 7.5) to provide an extract, homogenizing the extract to provide a homogenized extract, and centrifuging the homogenized extract to provide a soluble protein fraction and an insoluble protein fraction. The therapeutic composition can include about 87% soluble proteins and about 13% lipids.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: February 25, 2020
    Inventor: Jassim M. Hassan M. Ali
  • Patent number: 10406205
    Abstract: A method of treating diabetes can include administering a therapeutically effective amount of a composition comprising a soluble protein fraction obtained from epidermal gel secretions of catfish to a patient in need thereof. The soluble protein fraction can include soluble proteins and lipids from the epidermal gel secretions of catfish. The soluble protein fraction can include about 87% of the soluble proteins and about 13% of the lipids. The composition can be administered by intraperitoneal (IP) or sub-cutaneous (SC) injection.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: September 10, 2019
    Inventor: Jassim M. Hassan M. Ali
  • Patent number: 10385314
    Abstract: A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating a population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: August 20, 2019
    Assignee: EXOSTEM BIOTEC LTD.
    Inventors: Chaya Brodie, Shlomit Brodie
  • Patent number: 10377794
    Abstract: Herein is reported a method for the purification of an antibody directly captured from clarified cell culture supernatants using Streamline CST and/or Capto MMC, wherein especially product related (aggregates and fragments) and process related impurities (host cell protein, media components) could efficiently be removed, resulting in a preparation with a purity comparable to classical protein A affinity chromatography.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 13, 2019
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Roberto Falkenstein, Thorsten Lemm, Markus Strasser, Hidenari Yamada
  • Patent number: 10344260
    Abstract: The present invention relates to novel melanocytes and melanoblasts. In addition, the present invention relates to a novel method for producing melanocytes and melanoblasts. Specifically, provided is novel melanocytes of which gene expression, melanin content, and tyrosinase activity are different from those of conventional melanocytes. Even more specifically, provided is novel melanoblasts of which the gene expression, the melanin content the tyrosinase activity, and the protein expression are different from those of conventional melanocytes. Additionally, provided is a novel method for producing melanocytes or melanoblasts by culturing keratinocytes.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: July 9, 2019
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Eun Gyung Cho, Bum Ho Bin, Tae Ryong Lee, Ji Yeon Han, Hyun Jung Choi
  • Patent number: 10328122
    Abstract: A method of treating fulminant hepatic failure in a subject, includes administering a therapeutically effective amount of a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises a DLL4 cytokine. A method of treating liver failure, sub-acute liver failure, chronic liver failure or acute-on-chronic liver failure in a subject, includes administering an therapeutically effective amount of a DLL4 cytokine to the subject.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: June 25, 2019
    Assignee: Zhejiang University
    Inventors: Jun Li, Lanjuan Li, Xin Chen, Jiang Li
  • Patent number: 10265345
    Abstract: The present invention provides a method for treatment of acute cerebrovascular diseases, and also provides the use of the extracts from rabbit skin inflamed by vaccinia virus in the manufacture of a medicament for treatment of acute cerebrovascular diseases.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: April 23, 2019
    Assignee: Vanworld Pharmaceutical (Rugao) Co., Ltd.
    Inventor: Mansang Lau
  • Patent number: 10261068
    Abstract: The methods disclosed herein relate to an improved tool incorporating platelet count into a multi-biomarker based outcome risk stratification model for evaluating mortality risk in pediatric patients having sepsis. The methods described here are useful for treating sepsis, for point of care clinical decision support, for stratifying septic shock patients based on baseline mortality risk, and for clinical trial design, among other uses.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: April 16, 2019
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventor: Hector R. Wong
  • Patent number: 10251833
    Abstract: Described herein are compositions that contract and reduce pore size. The compositions of the disclosure are also useful for collagen contraction of the skin, calming skin, and reducing oil on the skin. The compositions comprise cosmetic ingredients such as glycerin; cyclopentasiloxane; polysilicone-11; pentaerythrityl tetraethylhexanoate; dipropylene glycol; methyl methacrylate crosspolymer; betaine; bis-PEG/PPG-16/PPG-16/16 PEG/16 dimethicone; Albizia julibrissin bark extract; Evodia rutaecarpa fruit extract; hydrolyzed soy flour; sea whip extract; and a dermatologically acceptable vehicle.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: April 9, 2019
    Assignee: Mary Kay Inc.
    Inventors: David Gan, Geetha Kalahasti, Lisha Van Pelt
  • Patent number: 10227290
    Abstract: Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: March 12, 2019
    Assignees: The Regents of the University of California, President and Fellows of Harvard College
    Inventors: Michael A. Fischbach, Jeffrey A. Bluestone, Cristina Penaranda, Laura Brown, Jon Clardy
  • Patent number: 10172707
    Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: January 8, 2019
    Assignees: Humacyte, Inc., Yale University
    Inventors: Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
  • Patent number: 10149874
    Abstract: A method is provided for treating a seaweed extract having a target molecule and a pyrogenic agent. The method includes inactivating the pyrogenic agent and/or removing the pyrogenic agent. The method results in a reduction in pyrogenicity of the extract. The method is useful in the preparation of pharmaceutical compositions and biomaterials for which pyrogen removal is critical.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: December 11, 2018
    Assignee: MARINOVA PTY LTD
    Inventors: Charles Dragar, Janet Helen Fitton, Vicki-Anne Gardiner, Damien Stringer, Samuel Karpiniec
  • Patent number: 10132805
    Abstract: A method for determining the amount of specific analyte of a sample which may show interferences by photometric assays, wherein the analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte. An interference test is performed simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample. The amount of each interfering substances is compared to predetermined cut-off values. The optical signal for the specific analyte is measured in the reaction mixture at multiple wavelengths over the complete reaction time, and a calibration curve is selected depending on the interfering substances. The amount of specific analyte is quantified by comparison with the selected calibration curve for the chosen wavelengths.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: November 20, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Georg Kurz, Eloisa Lopez-Calle
  • Patent number: 10111823
    Abstract: Shaving cream formulations can extend the life of shaving blades.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: October 30, 2018
    Assignee: GETCO LLC
    Inventors: Michael R. Cure, Peter Curtis
  • Patent number: 10058632
    Abstract: A placental construct is provided. The placental construct includes a therapeutically effective amount of human birth tissue material and a nanoparticle composition. Methods of treatment with the placental construct and a corresponding kit are also provided.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: August 28, 2018
    Assignee: Brahm Holdings, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 9956246
    Abstract: A solid composition comprising the following components (A) and (B): (A) from 20 to 65 mass % of a fat globule membrane component; and (B) from 0.2 to 4 mass % of a water-soluble dietary fiber having a weight average molecular weight of 10,000 or more.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 1, 2018
    Assignee: KAO CORPORATION
    Inventors: Yuki Ishida, Youichi Arai, Yasushi Shioya
  • Patent number: 9943553
    Abstract: To provide a method for producing an oyster meat essence that more amply incorporates an antioxidant substance with high ORAC value as follows. A portion of an oyster meat extract more amply incorporating an antioxidant substance with high ORAC value is selected. An extraction method that allows incorporating further large amount of antioxidant substance with high ORAC value is employed. The beneficial oyster meat extract can be efficiently extracted in large amounts. Object An oyster meat is stored in an extraction container where water is accumulated. An oyster meat essence is extracted to generate an extract liquid. The extract liquid is injected to a centrifuge, and concurrently the centrifuge is rotated at a centrifugal acceleration where an antioxidant substance with high antioxidative potency and ORAC value is separated and removed from the extract liquid. The antioxidant substance with higher antioxidative potency and ORAC value is separated.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: April 17, 2018
    Assignee: WATANABE OYSTER LABORATORY CO., LTD.
    Inventors: Mitsugu Watanabe, Takayuki Watanabe, Hideaki Watanabe
  • Patent number: 9931361
    Abstract: The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains N. brasiliensis excretory/secretory antigen (NES) or an immune triggering portion thereof. The invention also relates to a method of accelerating wound healing in a subject in need of such treatment.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: April 3, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: William C. Gause, Fei Chen, Zhugong Liu, Pankaj Mishra
  • Patent number: 9879042
    Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: January 30, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Alice L. Yu, Kun-Hsien Lin, Tai-Na Wu
  • Patent number: 9840627
    Abstract: The present invention provides application of camptothecin and derivatives thereof as antifouling agent, relating to camptothecin. Application of camptothecin and derivatives thereof as antifouling agent for facilities in water is provided, wherein the antifouling agent contains camptothecin and/or at least one of its derivatives. The application of camptothecin and derivatives thereof as antifouling agent for facilities in water can be used to prevent attachment of marine or freshwater micro-fouling organisms and/or large fouling organisms to the surfaces of facilities in the sea, lake, river or pool. The antifouling agent may also be used in mixture with other antifouling substance. Antifouling method for artificial facilities in water is provided. An antifouling paint for facilities in water is provided. Camptothecin and its derivatives have significant inhibitory activity to the attachment of fouling organisms, i.e.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: December 12, 2017
    Assignee: Xiamen University
    Inventors: Danqing Feng, Caihuan Ke, Wei Wang, Xiang Wang, Jian He, Hui Liu
  • Patent number: 9789224
    Abstract: Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karen Christman, Jennifer Singelyn, Jessica Dequach
  • Patent number: 9782476
    Abstract: Glycosphingolipids (GSLs) bearing ?-glucose (?-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with ?-glucose (?-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with ?-galactose (?-Gal) are disclosed. GSLs bearing ?-glucose (?-Glc) and derivatives of ?-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with ?-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with ?-Glc and derivatives thereof are provided.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: October 10, 2017
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Alice L. Yu, Kun-Hsien Lin, Tai-Na Wu
  • Patent number: 9759728
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods and kits for determining the human sperm quality.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: September 12, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Droit et de la Sante de Lille 2, Centre Hospitalier Regional Universitaire de Lille
    Inventors: Nicolas Sergeant, Valerie Mitchell, Fanny Jumeau, Julien Sigala
  • Patent number: 9713637
    Abstract: The invention provides an isolated Bacillus cereus sensu lato strain, selected from Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis, in which the htrA gene or any part thereof is silenced, and vaccines comprising the same.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: July 25, 2017
    Assignee: State of Israel Prime Minister's Office Israel Institute for Biological Research
    Inventors: Ofer Cohen, Theodor Chitlaru, Avigdor Shafferman
  • Patent number: 9707258
    Abstract: The present invention relates to the use of a Bifidobacterium strain for the preparation of compositions, in particular of an infant formula, intended for the prevention and/or treatment of allergic-type manifestations. These compositions are obtained from a Bifidobacterium culture, without hydrolyzing milk proteins. The bacteria, which preferably belong to the species Bifidobacterium breve, may be killed or removed from the composition during the process.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: July 18, 2017
    Assignee: Compagnie Gervais Danone
    Inventors: Cécile Aubert-Jacquin, Francis Lecroix, Emmanuel Perrin, Valérie Petay
  • Patent number: 9694109
    Abstract: A placental construct is provided. The placental construct includes a therapeutically effective amount of human birth tissue material and a nanoparticle composition. Methods of treatment with the placental construct and a corresponding kit are also provided.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: July 4, 2017
    Assignee: Brahm Holdings, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 9676838
    Abstract: Use of a nutritional supplement for increasing the bacterial mass in the rumen of a ruminant. The nutritional supplement includes proteins with a degree of hydrolysis above 28% and has more than 23 mg ?-amino nitrogen per gram of protein. The hydrolyzed proteins are preferably hemoglobin.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 13, 2017
    Assignee: APC EUROPE S.A.
    Inventors: Francisco Javier Polo Pozo, Carmen Rodriguez Canel, Alejandro Bach Ariza, Anna Aris Giralt
  • Patent number: 9642817
    Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: May 9, 2017
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Marcelle Machluf, Tomer Bronshtein
  • Patent number: 9629880
    Abstract: To provide a method for producing an oyster meat essence that more amply incorporates an antioxidant substance with high ORAC value as follows. A portion of an oyster meat extract more amply incorporating an antioxidant substance with high ORAC value is selected. An extraction method that allows incorporating further large amount of antioxidant substance with high ORAC value is employed. The beneficial oyster meat extract can be efficiently extracted in large amounts. Object An oyster meat is stored in an extraction container where water is accumulated. An oyster meat essence is extracted to generate an extract liquid. The extract liquid is injected to a centrifuge, and concurrently the centrifuge is rotated at a centrifugal acceleration where an antioxidant substance with high antioxidative potency and ORAC value is separated and removed from the extract liquid. The antioxidant substance with higher antioxidative potency and ORAC value is separated.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: April 25, 2017
    Assignee: Watanable Oyster Laboratory Co., Ltd.
    Inventors: Mitsugu Watanabe, Takayuki Watanabe, Hideaki Watanabe
  • Patent number: 9566369
    Abstract: A method for producing sterile, decellurized bioprosthetic tissue comprising: (a) contacting a human tissue with a hypotonic solution to produce a lysed tissue, (b) contacting the lysed tissue with a first surfactant to produce a surfactant-treated tissue, (c) contacting the surfactant-treated tissue with a nuclease enzyme solution to produce an enzyme-treated tissue, (d) contacting the enzyme-treated tissue with a cleaning solution comprising a second surfactant, a chaotropic agent or a mixture thereof to produce a decellurized tissue and (e) contacting the decellurized tissue with a bioburden reducing agent to produce the final bioprosthetic tissue. Kits to be used in conjunction with said method, as well as, the bioprosthetic tissue produced via said method are also provided.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: February 14, 2017
    Assignee: DECELL TECHNOLOGIES INC.
    Inventor: Paul F. Gratzer
  • Patent number: 9555116
    Abstract: The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolyzed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: January 31, 2017
    Inventor: Michael Anthony Folan
  • Patent number: 9511098
    Abstract: A method for producing dry earthworm powder, by which dry earthworm powder having high-titer enzymes can be produced while removing toxic substances contained in the bodies of earthworms, is provided. The method comprises: contacting a live earthworm with a chloride(s) of at least one metal selected from the group consisting of potassium, sodium, magnesium and calcium; and subsequently contacting the live earthworm with powder of a hydroxycarboxylic acid(s) and diluting the resulting mixture with water to adjust pH to 2 to 5, followed by leaving the live earthworm to stand for 3 to 180 minutes, washing the live earthworm with water, grinding the washed live earthworm and freeze-drying the obtained ground product.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: December 6, 2016
    Assignee: WELL STONE CO.
    Inventor: Kazuyuki Ishii
  • Patent number: 9474829
    Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: October 25, 2016
    Assignee: ACell, Inc.
    Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
  • Patent number: 9383358
    Abstract: The invention is directed to a method to establish a biologically significant association of gene expression levels among two or more genes, the method comprising assaying a sample for expression levels of two or more genes and identifying statistically-significant associations using a correlation coefficient in the range of about 0.6 to about 1.0, wherein a correlation coefficient in that range signifies a biologically significant correlation.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 5, 2016
    Assignee: CellPrint IP Holding, LLC
    Inventor: David R. Kaplan
  • Patent number: 9265804
    Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: February 23, 2016
    Assignee: Decoy Biosystems, Inc.
    Inventor: Michael J. Newman
  • Patent number: 9259444
    Abstract: The subject of the present invention is a bioactive cell homogenate produced from cells belonging to the MIC-1 stem cell line derived from growing deer antlers (Cervidae) deposited at the DSMZ under the accession DSM ACC2854, a method of producing and using it. The present invention also encompasses a pharmaceutical or cosmetic composition containing the above-mentioned homogenate.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: February 16, 2016
    Assignee: STEM CELLS SPIN S.A.
    Inventors: Wojciech Dziewiszek, Marek Cegielski, Marek Bochnia
  • Patent number: 9211307
    Abstract: Compositions containing acellularized biomaterial derived from differentiating pluripotent cells, for example, embryonic stem cells are provided. The acellularized biomaterial can be used to promote wound healing, promote tissue regeneration, or inhibit scarring. Methods for using the acellularized biomaterial for treating degenerative diseases are also provided.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: December 15, 2015
    Assignee: Georgia Tech Research Corporation
    Inventors: Todd Christopher McDevitt, Rehka Ramachandran Nair
  • Patent number: 9157840
    Abstract: The present inventive concept provides a multiple separation device and a method of separating a blood cancer cell using the same. In the device and the method, a blood sample is put in a fine channel and then cancer cells can be separated according to the type of cancer by controlling a flow velocity of the blood or a magnetic force of ferromagnetic pattern.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: October 13, 2015
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Seong-Mok Cho, Dae-Sik Lee, Jeong Won Park, Moon Youn Jung