Derived From Mollusk Patents (Class 424/547)
  • Patent number: 10568938
    Abstract: Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: February 25, 2020
    Assignee: Jiangyin Bengt I. Samuelsson Institute of Life Science Co., Ltd.
    Inventors: Bengt Ingemar Samuelsson, Min Gao
  • Patent number: 10391050
    Abstract: The present invention relates to a product obtained from gastropod spawn, to be used to prepare dermatological, cosmetic or cosmeceutical compositions designed for skin care; said product has the capacity to activate and mobilize skin stem cells, as well as prevent the loss thereof that takes place as a consequence of chronological and premature ageing. The present invention also relates to the process followed in order to obtain said product.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: August 27, 2019
    Assignee: Industrial Farmacéutica Cantabria, S.A.
    Inventors: Marta Dominguez Valdes-Hevia, Aurora Brieva Delgado, Salvador Gonzalez Rodriguez, Eduardo Reyes Martin, Jose Carballeira Morado, Ernesto Quintana Gonzalez, Juan Pablo Pivel Ranieri, Antonio Guerrero Gomez-Pamo, Angeles Juarranz De La Fuente, Jesus Espada Regalado, Francisco Sanz Rodriguez
  • Patent number: 10314876
    Abstract: A therapeutic method for treating diabetes mellitus, particularly diabetes caused by pancreatitis, comprising administering an effective amount of a Chinese herbal medicine to a subject. The Chinese herbal medicine is an extract of a mixture comprising specific amount of raw oyster shell powder, raw Os Draconis, Haematitum (Hematite), Magnetitum (Magnetite), radix Achyranthis Bidentatae (Achyranthes bidentata), rhizoma Dioscoreae (Dioscoreae Rhizoma), radix Paeoniae Rubra (Paeoniae Radix Rubra), radix Rehmanniae (Rehmannia), semen Platycladi (Platycladi Semen), Coptidis Rhizoma, cortex Mori, rhubarb (Rhei Radix et Rhizoma), and Davallia formosana (Davallia formosana Hay.).
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: June 11, 2019
    Inventor: Chen-Yu Lee
  • Patent number: 9744196
    Abstract: The present invention relates to a field of veterinary and human medicine. In particular, the invention relates to a composition suitable for parenteral administration, based on hydrolyzate obtained from natural bioresources, a composition for use in treating and/or preventing a pathological condition in a mammal in need thereof, and various other uses thereof. More particularly the invention relates to a composition having immunomodulatory properties being based on a hydrolyzate obtained from bioresources, which composition is used for parenteral administration to a mammal in need thereof.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 29, 2017
    Assignee: N2 PHARMACEUTICALS LTD
    Inventor: Nikolay Vladimirovich Solovyev
  • Patent number: 9730872
    Abstract: A method for improving skin conditions containing applying a composition containing veratric acid or acceptable salt thereof as an active ingredient. The composition has an excellent effect of reducing skin wrinkles through molecular mechanisms including the promotion of collagen synthesis and inhibition of collagenase activity. Also, the composition has an excellent effect of reducing wrinkles by absorbing UVB to prevent UV rays from penetrating the skin, promotion of collagen synthesis and inhibition of collagenase activity. In addition, the composition has effect of promotion of hair growth and the prevention of hair loss through growth promotion of hair dermal papilla cells, stimulation of IGF-1 secretion, and inhibition of TGF-beta1 secretion. Also, because the composition is derived from plants such as natural materials, it is harmless to the human body and can be safely applied to cosmetic, pharmaceutical, and food compositions.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: August 15, 2017
    Assignee: BIO SPECTRUM, INC.
    Inventors: Seoung Woo Shin, Eun Sun Jung, Deok Hoon Park
  • Patent number: 9125964
    Abstract: The present invention is related to a pharmaceutical composition comprising snail slime of Helix aspersa müller (Cryptophalus aspersus) (5% to 50%) and marigold extract, propolis and/or almond oil and pharmacologically accepted additives for the prevention additives and/or pharmaceutically acceptable excipients to form a formulation of intermediate to high viscosity (200 to 1000 Pa-s). This invention also relates to the use of a composition which can be formed as a cream or a gel, is preferably soaked in gauze, and shaped as a bandage or sock for the treatment and cure of diabetic foot ulcers and other severe wounds, particularly those associated with diabetes, gout, Lesch Nyhan syndrome or other conditions to the skin, including, keratosis, onychomycosis, ringworm, among others.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: September 8, 2015
    Assignee: Muciderm S.A.
    Inventors: Elmo Ernesto Moreno González, Nieves Galdames Flores
  • Patent number: 9066873
    Abstract: A white, color-stable, stain-free emulsion formulation containing vanillin for sunless tanning. The amount of vanillin can be adjusted, from about 1% up to about 45%, to provide light or dark tanning of the skin. Lime oil and lime juice form a preferred white emulsion foundation.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: June 30, 2015
    Inventor: Louise Holyfield
  • Patent number: 9060946
    Abstract: A white, color-stable, stain-free emulsion formulation containing vanillin for sunless tanning. The amount of vanillin can be adjusted, from about 1% up to about 45%, to provide light or dark tanning of the skin. Lime oil and lime juice form a preferred white emulsion foundation.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: June 23, 2015
    Inventor: Louise Holyfield
  • Publication number: 20150125542
    Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Inventors: Nobuaki OHTO, Akinori KISO
  • Patent number: 8722099
    Abstract: The present invention relates to a porous bioceramic composition for bone repair and method of fabrication of the same. 3D-scaffolds were fabricated with a novel micro- and macro-architecture. Porous scaffolds based on dextrin, dextran, gelatin and biomineral (CaCO3) powder were fabricated by heating and freeze-drying methods. Fabrication of different compositions of porous scaffolds (20, 30 wt % of gelatin, 20, 40 wt % dextrin, 30, 40, 50, 60 wt % dextran bounder with the constant quantity of CaCO3 50 g). The scaffolds properties were characterized by x-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and compression tests.
    Type: Grant
    Filed: September 28, 2013
    Date of Patent: May 13, 2014
    Assignee: Universiti Putra Malaysia
    Inventors: Md Zuki Abu Bakar, Bahaa Fakri Hussein, Noordin Mohamed Mustapha, Norimah Yusof, Elias Saion
  • Publication number: 20140106001
    Abstract: Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts. Production of collagen, elastin and hyaluronic acid are increased after application of the compositions.
    Type: Application
    Filed: October 15, 2013
    Publication date: April 17, 2014
    Applicant: COMMERCIAL MARINE BIOLOGY INSTITUTE, LLC
    Inventor: Eric Lewis
  • Publication number: 20140044789
    Abstract: This invention provides melanin nanoshells and their use for protection against radiation, particularly ionizing radiation, and electronic pulses, and methods of making materials comprising melanin nanoshells.
    Type: Application
    Filed: October 22, 2013
    Publication date: February 13, 2014
    Applicant: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ekaterina Dadachova, Arturo Casadevall
  • Publication number: 20140023634
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA either alone or in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Application
    Filed: September 5, 2013
    Publication date: January 23, 2014
    Applicant: U.S. NUTRACEUTICALS, LLC d/b/a Valensa International
    Inventors: John A. MINATELLI, W. Stephen Hill, Rudi E. Moerck
  • Publication number: 20130337079
    Abstract: To provide a method for producing an oyster meat essence that more amply incorporates an antioxidant substance with high ORAC value as follows. A portion of an oyster meat extract more amply incorporating an antioxidant substance with high ORAC value is selected. An extraction method that allows incorporating further large amount of antioxidant substance with high ORAC value is employed. The beneficial oyster meat extract can be efficiently extracted in large amounts. Object An oyster meat is stored in an extraction container where water is accumulated. An oyster meat essence is extracted to generate an extract liquid. The extract liquid is injected to a centrifuge, and concurrently the centrifuge is rotated at a centrifugal acceleration where an antioxidant substance with high antioxidative potency and ORAC value is separated and removed from the extract liquid. The antioxidant substance with higher antioxidative potency and ORAC value is separated.
    Type: Application
    Filed: September 15, 2011
    Publication date: December 19, 2013
    Inventors: Mitsugu Watanabe, Takayuki Watanabe, Hideaki Watanabe
  • Patent number: 8597690
    Abstract: A method of treating a respiratory disease in an animal comprising the steps of administering to the animal an effective amount of a pharmaceutical composition comprising 1.5 parts by weight powdered fennel, 2.0 parts by weight powdered rhubarb, 1.0 part by weight powdered glycyrrhiza, 2.0 parts by weight powdered phellodendron bark, 1.0 part by weight powdered zedoary, 1.5 parts by weight powdered picrasma wood, 1.0 part by weight powdered matricaria chamomilla, 1.5 parts by weight powdered geranium herb, 1.0 part by weight powdered ginseng, 1.5 parts by weight powdered citrus unshiu peel, 1.0 part by weight powdered scutellaria root, 1.0 part by weight powdered magnolia bark, 2.0 parts by weight powdered oyster shell, 1.0 part by weight powdered cyperus rhizome, 2.0 parts by weight powdered platycodon root, 2.0 parts by weight powdered melia azedarach, 1.0 part by weight powdered cnidium rhizome, 2.0 parts by weight sodium bicarbonate and 4.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: December 3, 2013
    Assignee: Nakamori Pharmaceutical Co., Ltd.
    Inventor: Toshio Nakamori
  • Publication number: 20130309296
    Abstract: The present invention is related to a pharmaceutical composition comprising snail slime of Helix aspersa müller (Cryptophalus aspersus) (5% to 50%) and marigold extract, propolis and/or almond oil and pharmacologically accepted additives for the prevention additives and/or pharmaceutically acceptable excipients to form a formulation of intermediate to high viscosity (200 to 1000 Pa-s). This invention also relates to the use of a composition which can be formed as a cream or a gel, is preferably soaked in gauze, and shaped as a bandage or sock for the treatment and cure of diabetic foot ulcers and other severe wounds, particularly those associated with diabetes, gout, Lesch Nyhan syndrome or other conditions to the skin, including, keratosis, onychomycosis, ringworm, among others.
    Type: Application
    Filed: May 20, 2011
    Publication date: November 21, 2013
    Inventors: Elmo Ernesto Moreno González, Nieves Galdames Flores
  • Publication number: 20130287756
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Application
    Filed: June 11, 2013
    Publication date: October 31, 2013
    Inventors: John A. MINATELLI, W. Stephen Hill, Swati Sebastian Thomas, Lingan Rajendran, Rudi E. Moerck
  • Publication number: 20130259952
    Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 3, 2013
    Inventors: Nobuaki OHTO, Akinori KISO
  • Patent number: 8545894
    Abstract: The present invention relates to a porous bioceramic composition for bone repair and method of fabrication of the same. 3D-scaffolds were fabricated with a novel micro- and macro-architecture. Porous scaffolds based on dextrin, dextran, gelatin and biomineral (CaCO3) powder were fabricated by heating and freeze-drying methods. Fabrication of different compositions of porous scaffolds (20, 30 wt % of gelatin, 20, 40 wt % dextrin, 30, 40, 50, 60 wt % dextran bounder with the constant quantity of CaCO3 50 g). The scaffolds properties were characterized by x-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and compression tests.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: October 1, 2013
    Assignee: Universiti Putra Malaysia
    Inventors: Md Zuki Abu Bakar, Bahaa Fakri Hussein, Noordin Mohamed Mustapha, Norimah Yusof, Elias Saion
  • Patent number: 8541031
    Abstract: Disclosed are articles comprising layered nanocrystalline calcite and methods for forming nanocrystalline calcite layers and compositions comprising nanocrystalline calcite layers.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: September 24, 2013
    Inventors: Andrew S. Mount, Neeraj V. Gohad, Douglas C. Hansen, Karolyn Mueller, Mary Beth Johnstone
  • Publication number: 20130108706
    Abstract: The present invention relates to the field of nutritional support for individuals and reducing the effects of muscle conditions caused by high levels of physical activity. In particular, the invention provides dietary formulations, compositions comprising these formulations and uses of these compositions to support the body's muscle regeneration process.
    Type: Application
    Filed: June 6, 2011
    Publication date: May 2, 2013
    Inventor: Katja Svennevig
  • Publication number: 20130084342
    Abstract: A method of treating a respiratory disease in an animal comprising the steps of administering to the animal an effective amount of a pharmaceutical composition comprising 1.5 parts by weight powdered fennel, 2.0 parts by weight powdered rhubarb, 1.0 part by weight powdered glycyrrhiza, 2.0 parts by weight powdered phellodendron bark, 1.0 part by weight powdered zedoary, 1.5 parts by weight powdered picrasma wood, 1.0 part by weight powdered matricaria chamomilla, 1.5 parts by weight powdered geranium herb, 1.0 part by weight powdered ginseng, 1.5 parts by weight powdered citrus unshiu peel, 1.0 part by weight powdered scutellaria root, 1.0 part by weight powdered magnolia bark, 2.0 parts by weight powdered oyster shell, 1.0 part by weight powdered cyperus rhizome, 2.0 parts by weight powdered platycodon root, 2.0 parts by weight powdered melia azedarach, 1.0 part by weight powdered cnidium rhizome, 2.0 parts by weight sodium bicarbonate and 4.
    Type: Application
    Filed: September 20, 2012
    Publication date: April 4, 2013
    Inventor: Toshio NAKAMORI
  • Publication number: 20130064898
    Abstract: A composition for treating tumors caused by pancreatic, stomach, breast, or liver cancer, leukemia, lung or liver metastasis, and/or arterial aneurysm. The composition comprises in various parts; turtle shell, radix ranunculi ternati, rhizoma dioscoreae bulbiferae, concha arcae, fructus ligustri lucidi, cordyceps sinensis, dwarf lilyturf tuber, Whim brownii, radix astragali, angelica sinensis, radix pseudostellariae, spina date seed, fruit-spike of common selfheal, pericarpium citri reticulatae, costustoot, cape jasmine fruit, radix scrophulariae, radix rehmanniae, rhizoma corydalis, safflower, turmeric root-tuber, cortex moutan, concha ostreae, poria cocos, herba lysimachiae, the root of red-rooted salvia, isatis indigotica fort, honeysuckle, fructus forsythiae, cortex eucommiae, radix gentianae macrophyllae, radix paeoniae alba, subprostrate sophora, seman platycladi, snakegourd fruit, membrane of chicken gizzard, platycodon grandifiorum, and radix liquiritiae.
    Type: Application
    Filed: November 9, 2011
    Publication date: March 14, 2013
    Inventor: Aiying Li
  • Publication number: 20130022663
    Abstract: Breast cancer and breast disease are common in women and becoming more frequent in men. Early treatment is vital for better outcomes. This formula consists of a liquid anti-disease topical and/or intraductal anti-breast-disease and anti-cancer—including against precursors to cancer and atypical cells—formula that can be delivered to the source where breast cancer begins by use of a number of bio-available components and multiple diffusion and delivery systems, preventing and/or treating maladies that include, but are not limited to degenerative diseases and accumulation of toxins in the breast tissue. May include homeopathic remedies to be used topically or inside the breast with a delivery method to those regions and may be processed with or without photonic programming or an ionic delivery system for greater effectiveness.
    Type: Application
    Filed: July 19, 2011
    Publication date: January 24, 2013
    Inventor: Kevin Buckman
  • Patent number: 8323699
    Abstract: In a method of manufacturing a skin care cream containing baked shell powder, highly calcium-containing shells such as dead shells or pearls is baked and crushed to fine powder to obtain baked shell powder. Then, the obtained baked shell powder is added to mix with a raw material for manufacturing cosmetic cream.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: December 4, 2012
    Assignee: Kabushiki Kaisha Asadasyokai
    Inventor: Kazunobu Sanada
  • Publication number: 20120231071
    Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.
    Type: Application
    Filed: May 24, 2012
    Publication date: September 13, 2012
    Inventors: Annette Tobia, Marcy Alice, Bangying Su, Takashi Niwa
  • Publication number: 20120231087
    Abstract: The present invention relates to nutritional supplement compositions comprising krill meal and lipid insoluble ingredients. The compositions can be used to provide supplementary nutrition to humans or animals. The present invention relates also formulations, such as tablets, which are easy to administer to animals. It is also shown that krill meal added to animal food at low levels will improve the palatability of the product.
    Type: Application
    Filed: March 6, 2012
    Publication date: September 13, 2012
    Inventors: Inge Bruheim, Mikko Griinari, Stig Rune Remoy
  • Publication number: 20120195970
    Abstract: Compositions and methods of preparing and using such compositions to treat the symptoms of herpes virus.
    Type: Application
    Filed: April 6, 2012
    Publication date: August 2, 2012
    Inventor: Jeffrey Wycoff
  • Publication number: 20120148680
    Abstract: The invention discloses an eye cream, comprising the following components in part by weight: 2-16 parts of pearl, 0.2-2 parts of borax, 10-28 parts of VE, 0.005-0.05 parts of muscone, 0.2-3 parts of borneol, 30-90 parts of complexe contour des yeux 338Y324 and 0.05-2 parts of zinc carbonate hydroxide. The eye cream has strong moisturizing ability and continuous water lock effect, good abilities of inhibiting melanin and increasing skin lightness, and at the same time has the effects of improving skin texture, i.e. delaying skin aging.
    Type: Application
    Filed: May 3, 2011
    Publication date: June 14, 2012
    Applicant: MAYINGLONG PHARMACEUTICAL GROUP CO., LTD
    Inventor: Ping Chen
  • Publication number: 20120107410
    Abstract: The present invention relates to a product obtained from gastropod spawn, to be used to prepare dermatological, cosmetic or cosmeceutical compositions designed for skin care; said product has the capacity to activate and mobilise skin stem cells, as well as prevent the loss thereof that takes place as a consequence of chronological and premature ageing. The present invention also relates to the process followed in order to obtain said product.
    Type: Application
    Filed: January 28, 2010
    Publication date: May 3, 2012
    Applicant: Industrial Farmaceutica Cantabria, S.A.
    Inventors: Marta Dominguez Valdes-Hevia, Aurora Brieva Delgado, Salvador Gonzalez Rodriguez, Eduardo Reyes Martin, Jose Carballeira Morado, Ernesto Quintana Gonzalez, Juan Pablo Pivel Ranieri, Antonio Guerrero Gomez-Pamo, Angeles Juarranz De La Fuente, Jesus Espada Regalado, Francisco Sanz Rodriguez
  • Publication number: 20120070506
    Abstract: The present invention relates to a composition for an animal within a particular weight range including at least one non-steroidal anti-inflammatory drug (NSAID) compound and at least one mussel extract characterised in that the therapeutic dose of NSAID compound in the composition is substantially less than the usual therapeutic dose.
    Type: Application
    Filed: December 18, 2009
    Publication date: March 22, 2012
    Applicant: BOMAC RESEARCH LIMITED
    Inventor: Wayne Frederick Leech
  • Publication number: 20110287107
    Abstract: The present invention relates to a porous bioceramic composition for bone repair and method of fabrication of the same. 3D-scaffolds were fabricated with a novel micro- and macro-architecture. Porous scaffolds based on dextrin, dextran, gelatin and biomineral (CaCO3) powder were fabricated by heating and freeze-drying methods. Fabrication of different compositions of porous scaffolds (20, 30 wt % of gelatin, 20, 40 wt % dextrin, 30, 40, 50, 60 wt % dextran bounder with the constant quantity of CaCO3 50 g). The scaffolds properties were characterised by x-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and compression tests.
    Type: Application
    Filed: June 9, 2009
    Publication date: November 24, 2011
    Applicant: UNIVERSITI PUTRA MALAYSIA
    Inventors: Md Zuki Abu Bakar, Bahaa Fakri Hussein, Noordin Mohamed Mustapha, Norimah Yusof, Elias Saion
  • Publication number: 20110262552
    Abstract: Provided are compositions comprising Harpagophytum procumens (Devil's claw) root extract and Ribes nigrum (Black Currant) leaf or seed extract. Other components may also be included. Also provided are methods of preventing or treating inflammation or a condition that results from inflammation.
    Type: Application
    Filed: September 25, 2009
    Publication date: October 27, 2011
    Inventors: Guy Chamberland, Celine Devaux, Peter Bollen
  • Publication number: 20110195061
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA wither alone or in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Application
    Filed: April 4, 2011
    Publication date: August 11, 2011
    Applicant: U.S. Nutraceuticals, LLC d/b/a Valensa International
    Inventors: John A. MINATELLI, W. Stephen Hill, Rudi E. Moerck
  • Publication number: 20110189161
    Abstract: The present invention provides a proprietary compositions and systems to modulate genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and/or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplement formulation to optimize specific health outcomes. Specific to this invention the utilization of certain known polymorphic genes associated with Substance Use Disorder (SUD) are analyzed to target certain genetic anomalies that lead to a high risk and predisposition to SUD. The genotypic patterns are then utilized to provide certain nutritional customized solutions especially related to the attenuation of aberrant abuse of physician prescribed narcotic pain medication across all pain conditions.
    Type: Application
    Filed: June 22, 2009
    Publication date: August 4, 2011
    Inventors: Kenneth Blum, Roger L. Waite, B. William Downs, William J. Heaney
  • Publication number: 20110171187
    Abstract: The present invention provides a dietary supplement that promote the growth, repair, and maintenance of mammalian bone and joint connective tissue. In particular, the dietary supplement comprises a combination of at least one metal chelate and at least one chondroprotective agent.
    Type: Application
    Filed: May 30, 2008
    Publication date: July 14, 2011
    Applicant: Novus International, Inc.
    Inventors: Jeremy D. Moore, Thomas R. Hampton, Robert Harrell
  • Patent number: 7939492
    Abstract: Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for anti-microbial, anti-endotoxin, and anti-sepsis therapy. SSCrFCES is a 38 kDa protein representing the LPS-binding domain of Factor C. The ability of SSCrFCES to bind lipid A was analyzed using an ELISA-based assay as well as surface plasmon resonance. Surface plasmon resonance similarly carried out for SSCrFC-sushi-1,2,3-GFP, SSCrFC-sushi-1GFP, and SSCrFC-sushi-3GFP confirmed their superior affinity for endotoxin. The 50% endotoxin-neutralizing concentration of SSCrFCES against 200 EU of endotoxin is 0.069 ?M, suggesting that SSCrFCES is an effective inhibitor of LAL coagulation cascade. Although partially attenuated by human serum, as low as 1 ?M of SSCrFCES inhibits the LPS-induced secretion of hTNF-? and hIL-8 by THP-1 and human pheripheral blood mononuclear cells with a potency more superior than polymyxin B.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: May 10, 2011
    Assignee: National University of Singapore
    Inventors: Jeak L. Ding, BoW Ho, Nguan S. Tan
  • Publication number: 20110045099
    Abstract: A method of modulating inflammation in an organism, which includes administering to an organism a composition including a therapeutic amount of an extract from the plant Biota orientatis. Several key components of the extract of Biota orientalis have been identified that have also been shown to have an effect in dramatically reducing inflammatory responses.
    Type: Application
    Filed: December 12, 2008
    Publication date: February 24, 2011
    Inventor: Dan Bright
  • Publication number: 20110033556
    Abstract: A natural pharmaceutical preparation for treating hypoproteinemia, includes at least one member selected from the group consisting of a drug of increasing human serum albium, a drug of improving and enhance immunity, a drug of treating hepatitis B, a drug of treating Hepatitis C, a drug of treating acquired immune deficiency syndrome (AIDS), a drug of treating Tuberculosis, a drug of treat Fibrosis, a drug of treating hydrothorax, a drug of easing pain, a drug of stopping diarrhea, a drug of arresting coughing, a drug of reducing inflammation, and a drug of increasing urine.
    Type: Application
    Filed: June 4, 2010
    Publication date: February 10, 2011
    Inventors: Zheming Jin, Xitian Zhang
  • Publication number: 20110020316
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Application
    Filed: July 21, 2010
    Publication date: January 27, 2011
    Applicant: U.S. Nutraceuticals, LLC d/b/a Valensa International
    Inventors: John A. Minatelli, W. Stephen Hill, Swati Sebastian Thomas, Lingan Rajendran, Rudi E. Moerck
  • Publication number: 20110004218
    Abstract: The present invention relates to a method for the preparation of mechano-structured nacre by mechanosynthesis of micrometric nacre powder, characterized in that the temperature of the nacre is kept below 40° C. It also relates to the mechano-structured nacre and to uses thereof, in particular on implants and bone substitute pieces on which the mechano-structured nacre is deposited.
    Type: Application
    Filed: June 16, 2010
    Publication date: January 6, 2011
    Applicant: JD INVEST
    Inventors: Joël DRAI, Josette GUILLOT
  • Publication number: 20100297254
    Abstract: A method of treatment for cartilage degradation in an organism, which includes administering to an organism a composition including a therapeutic amount of an extract from the plant Biota orientalis. Several key components of the extract of Biota orientalis have been identified that have also been shown to have an effect in dramatically reducing and reversing cartilage degradation.
    Type: Application
    Filed: December 12, 2008
    Publication date: November 25, 2010
    Inventor: Dan Bright
  • Publication number: 20100291053
    Abstract: We describe a composition comprising a source of long chain polyunsaturated fatty acid, for example, docosahexaenoic acid (DHA), and a carotenoid, for example, astaxanthin and other nutrients for prophylactic and/or therapeutic use in the healing of trauma- and stress-induced inflammatory conditions.
    Type: Application
    Filed: June 23, 2004
    Publication date: November 18, 2010
    Inventors: Diane Clayton, Rebecca Rutter
  • Publication number: 20100068259
    Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.
    Type: Application
    Filed: May 29, 2009
    Publication date: March 18, 2010
    Inventors: Annette Tobia, Marcy Alice, Bangying Su, Takeshi Niwa
  • Patent number: 7595061
    Abstract: A method for controlling the growth of destructive insects and microorganisms in ground soil, includes the step of adding chitin to ground soil for inducing bacteria in the ground soil to synthesize chitinase for controlling the spread of destructive insects and microorganisms therein. The chitin may be added to the ground soil by distributing it on the upper surface of the soil or, preferably, by incorporating into the soil. In a preferred embodiment, the step of deacetylating the carbohydrate chains of the chitin for is carried out before adding to the ground soil for increasing the aqueous solubility of the chitin by producing smaller polymeric units or by increasing the availability of polar hydroxyl groups on glucosyl moieties thereof. Various bacterial cultures may also be added to the chitin prior to its distribution on, or incorporation in, the ground soil.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: September 29, 2009
    Inventor: David Abecassis
  • Publication number: 20090123559
    Abstract: The present invention declares a pharmaceutical extract, composition that has effect to treat drug addiction, and its preparation method and quality control method. This extract is extracted from Radix Stephaniae Epigaeae. Starting medicine material of said composition is Radix Ginseng, Radix Astragali, Rhizoma Corydalis, Radix Angelicae Sinensis and Radix Ophiopogonis; and said composition also can prepared by ethanol extract of Radix Ginseng, ethanol extract of Radix Angelicae Sinensis, total alkaloids of Radix Stephaniae Epigaeae, water extract of Radix Astragali and water extract of Radix Ophiopogonis. Quality control method of said pharmaceutical composition includes one of or several of identifications and content determinations. The present invention also declares the use of said pharmaceutical extract, composition in the preparation of a medicine to treat drug addiction.
    Type: Application
    Filed: July 26, 2006
    Publication date: May 14, 2009
    Applicant: Shanxi Yabao Pharmaceutical Group Corp.
    Inventors: Zheng Yang, Ming Fan, Jijun Chen, Guozhang Jin, Wuxian Ren, Wei Feng
  • Patent number: 7527799
    Abstract: The present invention is related to a method of manufacture of an alkaline mineral bioactive solution of which raw materials are squid bones burnt at a high temperature and crushed powder of red seaweeds and to compositions and health foods having the efficacy for the prevention of osteoporosis. The alkaline aqueous solutions having abundant minerals of the present invention may be used for bioactive solutions having the efficacy for the prevention and improvement of osseous diseases such as osteolysis and osteoporosis in mammals including human beings.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: May 5, 2009
    Inventors: Sung-Yong Hwa, Kyu-Shik Jeong, Sun-Hee Do, Won-Il Jeong, Da-Hee Jeong, Gi-Ppeum Lee, Eun-Mi Cho, Hoon Ji
  • Publication number: 20080274205
    Abstract: The present invention is related to a method of manufacture of an alkaline mineral bioactive solution of which raw materials are squid bones burnt at a high temperature and crushed powder of red seaweeds and to compositions and health foods having the efficacy for the prevention of osteoporosis. The alkaline aqueous solutions having abundant minerals of the present invention may be used for bioactive solutions having the efficacy for the prevention and improvement of osseous diseases such as osteolysis and osteoporosis in mammals including human beings.
    Type: Application
    Filed: April 15, 2005
    Publication date: November 6, 2008
    Inventors: Sung-Yong Hwa, Kyu-Shik Jeong, Sun-Hee Do, Won-Il Jeong, Da-Hee Jeong, Gi-Ppeum Lee, Eun-Mi Cho, Hoon Ji
  • Publication number: 20080220084
    Abstract: The present invention provides compositions and methods for alleviating physical discomfort and/or pain-related conditions in a subject, comprising one or more ingredients that improve blood circulation, one or more ingredients that reduce pain and one or more ingredients that enhance bone health. The ingredients are selected from synthetic compounds, natural products, natural ingredients, extracts from natural ingredients, or combinations thereof. The compositions of the invention are particularly useful in alleviating musculoskeletal pain and nerve related pain.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 11, 2008
    Inventors: Jian-Qiang FAN, Dawei Zhu
  • Patent number: 7416743
    Abstract: A polyherbal preparation for the prevention of atherosclerosis and hyperlipidemia comprising a mixture of Commiphora mukul, Boswellia serrata, Semecarpus anacardium Strychnox nux vomica, Terminalia arjuna and Shankha Bhasma.
    Type: Grant
    Filed: December 26, 2003
    Date of Patent: August 26, 2008
    Assignees: Department of Biotechnology, Banaras Hindu University
    Inventor: Yamini Bhushan Tripathi