Heavy Metal Containing Patents (Class 424/604)
  • Patent number: 11179309
    Abstract: This invention relates to a hair care composition which provides the desired anti-dandruff efficacy with uniform deposition of the active materials on hair/scalp. This is achieved through a judicious combination of a specific cationic deposition polymer and selective anti-dandruff agent of the right particle size.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: November 23, 2021
    Assignee: Conopco, Inc.
    Inventors: Shaokun Chang, Jingjing Liu, Yingying Pi, Raghupathi Subramanian
  • Patent number: 11077087
    Abstract: Disclosed is the use of a composition including dihydroquercetin and optionally ?-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating HSV infection and the associated inflammation.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 3, 2021
    Assignee: BIONOOX SUISSE SA
    Inventor: Christian Auclair
  • Patent number: 11000545
    Abstract: Provided herein are formulations containing copper ions and methods of treating underlying infections and conditions caused by coronavirus, particularly COVID-19, and influenzas, particularly influenza A and/or influenza B using such formulations. Methods of treating the underlying viruses and their resultant conditions using topical copper ion treatments are provided. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension may be combined with various carriers to form the copper ion treatment including creams or solutions. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: May 11, 2021
    Assignee: CDA RESEARCH GROUP, INC.
    Inventors: ChunLim Abbott, Dominic C. Abbott
  • Patent number: 10854896
    Abstract: A fuel cell system comprises an antimicrobial patterned surface. The fuel cell system may comprise a fuel cell stack, a coolant reservoir, and a coolant flow path configured to supply coolant from the coolant reservoir to the fuel cell stack. One or more of the fuel cell stack, the coolant reservoir and the coolant flow path may comprise the antimicrobial patterned surface.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: December 1, 2020
    Assignee: Intelligent Energy Limited
    Inventors: Mathias Crespy, Pratap Rama, Daniel Ninan
  • Patent number: 10301387
    Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 28, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen Willingham, Maureen Howard, Jie Liu, Ravindra Majeti, Susan Sweeney Prohaska, Anne Kathrin Volkmer, Jens-Peter Volkmer, Irving L. Weissman
  • Patent number: 9533010
    Abstract: The described invention provides methods and regimens for treating adverse consequences of a persistent and progressive myocardial injury-due to a vascular insufficiency that occurs early or late in a subject in need thereof, and progressive myocardial injury-preventing compositions that contain a chemotactic hematopoietic stem cell product, and, optionally, an additional active agent. The method treats ongoing vascular insufficiency affecting coronary circulation by (i) stimulating neoangiogenesis in a peri-infarct border zone, thereby improving myocardial perfusion; and, (ii) through a paracrine effect, preventing apoptosis of cardiomyocytes in the peri-infarct border zone. The neoangiogenesis and paracrine-mediated reduction of apoptosis reduces progressive myocardial cell loss, which leads to improvement in cardiac function and a reduction of risk of major adverse cardiovascular events.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: January 3, 2017
    Assignee: Amorcyte, LLC
    Inventors: Andrew L. Pecora, Robert A. Preti
  • Patent number: 9408383
    Abstract: A biocidal glass composition for use in roofing applications can include glass doped with at least one biocidal agent that includes about 0.01 wt. % to about 50 wt. % of a total weight % of the biocidal glass composition. The biocidal glass composition can be included in a coating on a base particle of a roofing granule. Further included is a process of forming the roofing granule.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 9, 2016
    Assignee: CERTAINTEED CORPORATION
    Inventors: Pierre-Olivier Petit, Keith C. Hong, Gregory F. Jacobs, Kamila Plevacova
  • Patent number: 9114187
    Abstract: An identification device that combines an antimicrobial coating with a printable substrate. For example, the invention includes a wristband with a face stock supporting indicia which are applied on (such as through thermal transfer printing) or through (such as through direct thermal printing) an antimicrobial layer. The antimicrobial layer is preferably a coating or varnish that is applied as the outermost layer and can bind with thermal transfer printing ink or supports pass through of direct thermal printing on a chemically receptive sublayer. The antimicrobial varnish includes varnish compounds and antimicrobial compounds such as a silver zeolite ion that is configured to react to moisture with a controlled release of microbial disinfectant. Preferably, the wristband is a hospital wristband bearing on-site printed identification indicia for a patient.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: August 25, 2015
    Assignee: ZIH Corp.
    Inventors: Gene Allen Hofer, David Macedon
  • Patent number: 9017953
    Abstract: The present invention encompasses methods and compositions for detecting pathogenic bacteria. Additionally, the present invention encompasses methods and compositions for catalyzing the dismutation of superoxide radicals.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: April 28, 2015
    Assignee: Washington University
    Inventors: Jeffrey P. Henderson, Chia Hung, Kaveri Chaturvedi
  • Publication number: 20150111732
    Abstract: A pesticidal composition comprises a 3-(1H-pyrazol)pyridine compound of formula I or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, R12, x, n, and Q are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Martin J. Walsh, Ann M. Buysse, Asako Kubota, Noormohamed M. Niyaz, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Publication number: 20150111731
    Abstract: A pesticidal composition comprises one or more of the following compounds: 3-(thiazol-2-yl)pyridine 1-oxide compound of formula I or II, or N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-3-(methylthio)propanamide compound (C3), or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Negar Garizi, Martin J. Walsh, Ann M. Buysse, Daniel Knueppel, Asako Kubota, Noormohamed M. Niyaz, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Publication number: 20150111733
    Abstract: A pesticidal composition comprises at least one compound selected from a 1-(3-pyridyl-N-oxide)pyrazole compound of formula I, II, or III, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R12, R13, Y, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Martin J. Walsh, Daniel Knueppel, Noormohamed M. Niyaz, Ann M. Buysse, Negar Garizi, Asako Kubota, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Publication number: 20150111734
    Abstract: A pesticidal composition comprises at least one compounds selected from a compound of formula, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, Q, Z, L, La, and x are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Yu Zhang, Asako Kubota, Noormohamed M. Niyaz, Thomas Barton, Tony K. Trullinger, Christian T. Lowe, Paul R. LePlae, Ann M. Buysse, Martin J. Walsh, Negar Garizi, Ricky Hunter, Daniel Knueppel
  • Patent number: 8940684
    Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 27, 2015
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Publication number: 20150017256
    Abstract: Method for producing condensed iron (III) phosphate, in which a) an aqueous solution containing Fe2+ ions is produced, in which oxidic iron (II), iron (III) or mixed iron (II, III) compounds selected from among hydroxides, oxides, oxide hydroxides, oxide hydrates, carbonates and hydroxide carbonates are introduced together with elementary iron into an aqueous medium containing phosphoric acid, wherein Fe2+ ions are dissolved and Fe3+ with elementary Fe (in a comproportionation reaction) is reacted to dissolved Fe2+, b) separating solid material from the phosphoric acid aqueous Fe2+ solution, c) adding an oxidizer to the phosphoric acid aqueous Fe2+ solution to oxidise iron (II) in the solution, d) adding polyphosphate in the form of polyphosphoric acid or salts thereof as solid material or aqueous solution after completion of the oxidation reaction to precipitate condensed iron (III) phosphate, and e) separating the precipitated condensed iron (III) phosphate solution and resulting product.
    Type: Application
    Filed: January 2, 2013
    Publication date: January 15, 2015
    Inventors: Gunnar Buehler, Manola Stay
  • Patent number: 8932644
    Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: January 13, 2015
    Inventor: Don M. Huber
  • Publication number: 20140315714
    Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.
    Type: Application
    Filed: July 1, 2014
    Publication date: October 23, 2014
    Inventor: Don M. HUBER
  • Patent number: 8852647
    Abstract: The present invention relates to compositions comprising a combination of pyrimethanil, or a salt thereof, together with one or more silver salts selected from silver acetate, silver alginate, silver azide, silver citrate, silver lactate, silver nitrate, silver sulfate, silver chloride, silver thiocyanate, silver-sodium-hydrogen-zirconium phosphate, silver sulfadiazine, silver cyclohexanediacetic acid and disilver 2,5-dichloro-3,6-dihydroxy-2,5-cyclohexadiene-1,4-dione; in respective proportions to provide a synergistic biocidal effect. Another suitable silver component (II) is nano-silver particles, typically with a particle size of 1-1000 nm. Compositions comprising these combinations are useful for the protection of any living or non-living material against deterioration due to the action of microorganisms such as bacteria, fungi, yeasts, algae, and the like.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 7, 2014
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Dany Leopold Jozefien Bylemans, Jan Pieter Hendrik Bosselaers, Mark Arthur Josepha Van Der Flaas
  • Publication number: 20140296068
    Abstract: This document discloses molecules having the following formula (Formula One) and processes related thereto.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 2, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Negar Garizi, Tony K. Trullinger, Ricky Hunter, Yu Zhang, Noormohamed M. Niyaz, Daniel Knueppel, Christian T. Lowe, Ann M. Buysse
  • Publication number: 20140271759
    Abstract: Antimicrobial chemical compositions comprise an aluminum phosphate (AlP) solid dispersed within a binding polymer, wherein one or more bioactive materials are disposed within AlP forming a bioactive-AlP complex. The complex may comprise the bioactive material chemically bonded with the AlP, physically combined with the AlP, or a combination of both. The complex may be formed according to precipitation, condensation and sol-gel methods of forming. The complex is engineered to provide a controlled delivery of the bioactive material or a constituent thereof upon exposure to moisture to give a desired level of antimicrobial resistance to a film or composite formed from the composition of at least about 30 ?g/m2, and may also provide a desired degree of corrosion resistance through the release of passivating phosphate anion.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: BUNGE AMORPHIC SOLUTIONS LLC
    Inventor: Raymond E. Foscante
  • Patent number: 8821945
    Abstract: Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: September 2, 2014
    Assignee: Fe3 Medical, Inc.
    Inventors: Mir Imran, Mir Hashim, Sanjay Patel, Ronald J. Berenson
  • Publication number: 20140242187
    Abstract: Compositions comprising ferrous and/or ferric iron compounds and fiber in a complex, methods for preparing such compositions of matter, and the use thereof for treatment of adsorbing certain accessible targets in the gastrointestinal tract and in an extracorporeal system, are provided herein.
    Type: Application
    Filed: October 12, 2012
    Publication date: August 28, 2014
    Inventor: Jinshyun Ruth Wu-Wong
  • Publication number: 20140234437
    Abstract: In one of its aspects, the present invention provides a composition comprising: (i) a non-encapsulated iron salt, and (ii) a carrier comprising digestible edible oil that is a liquid at 20° C. This composition advantageously provides iron in a form that is easily administered to an infant or adult. When taken directly by mouth or added to food or infant formula, the composition has a desirably bland flavor and is easy to consume. Moreover, the high density of iron per unit volume of the composition results in a minimal volume of liquid to be administered. This makes the composition relatively innocuous and easy for infants to consume. Related aspects of the present invention are also described—e.g., uses, articles of manufacture and the like.
    Type: Application
    Filed: July 5, 2012
    Publication date: August 21, 2014
    Inventor: Reinhold Vieth
  • Publication number: 20140227366
    Abstract: The present invention relates to a biocide improvement system wherein the biocide is reversibly bound into a matrix of an organic polymer and inorganic solid particles and thus is slowly released in the soil.
    Type: Application
    Filed: May 11, 2012
    Publication date: August 14, 2014
    Inventors: Oliver Zindel, Karla Kaminski, Frank Iding, Volker Windhoevel
  • Patent number: 8795736
    Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: August 5, 2014
    Inventor: Don M. Huber
  • Publication number: 20140171310
    Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 19, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: William C. Lo, James E. Hunter, Gerald B. Watson, Akshay Patny, Pravin S. Iyer, Joshodeep Boruwa
  • Publication number: 20140141096
    Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 22, 2014
    Applicant: MiMedx Group, Inc.
    Inventor: MiMedx Group, Inc.
  • Patent number: 8715745
    Abstract: The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: May 6, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: David H Young, Cruz Avila-Adame, Nneka T Breaux, James M Ruiz, Thomas L Siddall, Jeffery D. Webster, Gerald Shaber
  • Publication number: 20140107555
    Abstract: A wound dressing includes one or more layers containing an antimicrobial agent and optionally at least one of: a chelating agent, a second antimicrobial agent, a zinc-containing agent, a cell-signaling agent, and an additional active ingredient or agent.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicant: Covidien LP
    Inventor: Harish Patel
  • Patent number: 8691285
    Abstract: Methods of using a non-irritant, low pH acidic composition to destroy undesirable microorganisms are described. The methods may be used on food products, food processing equipment, and in aqueous solutions.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: April 8, 2014
    Assignee: CMS Innovative Technologies, Inc.
    Inventors: Barry Cummins, David Creasey
  • Publication number: 20140069005
    Abstract: The present disclosure provides methods and compositions for treating fungal diseases of plants. In one embodiment, an anti-fungal aqueous composition can comprise: a nitrogen source material having a total nitrogen content in an amount of about 0.1 wt % to about 0.5 wt % of the total weight of the composition, a phosphate source material having total phosphate content in an amount of about 0.05 wt % to about 0.15 wt % of the total weight of the composition, a potassium source material with a soluble potash content in an amount of about 0.05 wt % to about 0.15 wt % of the total weight of the composition, and a sulfur source material in an amount of about 0.005 wt % to about 0.02 wt % of the total weight of the composition.
    Type: Application
    Filed: September 25, 2013
    Publication date: March 13, 2014
    Inventor: Steven R. Teerlink
  • Publication number: 20140050879
    Abstract: Methods and treatment compositions for imparting durable antimicrobial properties to carpet are provided. The method includes applying a composition comprising a first antimicrobial compound and a fluoropolymer to the carpet substrate. The carpet substrate may be steamed thereafter. The treatment composition may comprise a fluoropolymer, an antimicrobial compound selected from a group consisting of zinc pyrithione, a silver-containing antimicrobial compound and combinations thereof, and a foamer. Carpet products treated with the treatment composition or treated in accordance with the methods are also provided.
    Type: Application
    Filed: October 24, 2013
    Publication date: February 20, 2014
    Applicant: Beaulieu Group, LLC
    Inventors: Todd Mull, James Lesslie, Danny S. Wade
  • Patent number: 8568759
    Abstract: The present invention provides an environmentally compatible, pesticidal composition and method for the control of insect pests. The composition includes two components. The first component is a chelating agent, a metal complex of a chelating agent, and mixtures thereof, and the second component is preferably a carrier material.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: October 29, 2013
    Assignee: W. Neudorff GmbH KG
    Inventor: Diana L. Parker
  • Publication number: 20130273173
    Abstract: Embodiments provide apparatus and methods for delivering solid form medications such as pellets to various locations in the body. One embodiment provides an apparatus for in vivo delivery of medication pellets comprising a housing including a port, a pellet-containing belt disposed in the housing, and a mechanism for transferring the pellets from the belt to a delivery site (DS) outside the housing. Each pellet contains a dose of drug to treat a medical condition. An elongate member is coupled to the housing and includes a lumen for pellet delivery, a proximal end coupled to the port and a distal end positioned at the DS. The pellet can be delivered to the DS at regular intervals or responsive to a detected biological event. Embodiments of the invention are particularly useful for delivering medication to treat a medical condition over an extended period without requiring a patient to take external medication.
    Type: Application
    Filed: October 4, 2012
    Publication date: October 17, 2013
    Applicant: InCube Labs, LLC
    Inventor: Mir Imran
  • Publication number: 20130274372
    Abstract: Antimicrobial chemical compositions comprise an aluminum phosphate (AlP) solid dispersed within a binding polymer, wherein one or more bioactive materials are disposed within AlP forming a bioactive-AlP complex. The complex may comprise the bioactive material chemically bonded with the AlP, physically combined with the AlP, or a combination of both. The complex may be formed according to precipitation, condensation and sol-gel methods of forming. The complex is engineered to provide a controlled delivery of the bioactive material or a constituent thereof upon exposure to moisture to give a desired level of antimicrobial resistance to a film or composite formed from the composition of at least about 30 ?g/m2, and may also provide a desired degree of corrosion resistance through the release of passivating phosphate anion.
    Type: Application
    Filed: April 16, 2012
    Publication date: October 17, 2013
    Applicant: Bunge Amorphic Solutions LLC
    Inventor: Raymond E. Foscante
  • Publication number: 20130216574
    Abstract: The present invention discloses a unique kit for providing a combinational therapeutic product comprising a medical device and a pharmaceutical composition to treat mammal diseases. The medical device is to meet these unmet needs of cleansing out these harmful substances, such as viruses, multiple drug resistant bacteria, fungi, pollen, dusts, or excessive mucus. The pharmaceutical composition adds the required functions of anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, to have the added effect of the medical device. The method of using the combinational product is also disclosed. The new product can be used to prevent and treat a variety of diseases, such as common cold, drug resistant influenza, sinusitis, post nasal drip, virus-triggered asthma, or chronic obstructive pulmonary disease. In addition, the new kit and the process of use are safe and cost effective.
    Type: Application
    Filed: February 20, 2012
    Publication date: August 22, 2013
    Inventor: James Liu
  • Patent number: 8512760
    Abstract: A process for the production of an aqueous dispersion of metal nano particles comprising palladium is provided. The process comprises the admixture of a water soluble organic polymer, a palladium salt and a first reducing agent to an aqueous liquid. The first reducing agent is a metal-containing polymer which has reducing properties or a saccharide which has reducing properties. The nano particles can include a second metal. The dispersions can be used as catalysts for electroless plating, to produce heterogeneous catalysts and in the production of anti-microbial devices and compositions.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: August 20, 2013
    Assignee: The University Court of the University of Dundee
    Inventors: James Anthony Cairns, Roderick Allan George Gibson, Graham James Berry
  • Patent number: 8486424
    Abstract: One embodiment includes a method including boiling unsalted butter over low heat until it appears golden to form purified butter; cooling the purified butter by removing it from the heat; straining or filtering the purified butter; refrigerating the purified butter for at least 24 hours; thoroughly blending together the elements of an organic carrier medium, wherein the organic carrier medium comprises the purified butter, olive oil, and honey; adding distilled water to the blended organic carrier medium; mixing the distilled water and the blended organic carrier medium at high speed; and adding at least one of sodium acid pyrophosphate, cornstarch, bismuth subnitrate, salicylic acid, or alkali metal salicylates, and mixing.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: July 16, 2013
    Inventor: Radmila Stojkoski
  • Publication number: 20130177610
    Abstract: A system for delivering nano-metallic alloys to infected cells in a patient is disclosed. The nano-metallic alloy may be formed from binary, triple, or quadruple elemental compositions complexed in predetermined percentages of monosodium phosphate monohydrate and disodium phosphate heptahydrate. The nano-metallic alloy may be capable of eliminating infectious microorganisms within infect cells or legions without harming the cells or tissues. The system may also include a method of administering a predetermined concentration of the nano-metallic alloy in the complexing solution in the vicinity of the infected cells of legions to kill the foreign matter.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 11, 2013
    Applicant: UNIVERSITY OF NORTH CAROLINA AT GREENSBORO
    Inventor: UNIVERSITY OF NORTH CAROLINA AT GREENSBORO
  • Publication number: 20130171224
    Abstract: The combination of a first species which is a polyanionic compound and a second species which is an antimicrobial agent is used for the treatment of microbial biofilms and for the topical treatment of wounds. The combination may be incorporated in a wound dressing. The polyanionic compound may be a polyphosphate, such as an alkali metal polyphosphate, e.g. sodium hexametaphosphate. Examples of antimicrobial agents include metallic silver, silver compounds, iodine, PHMB (polyhexamethylene biguanide), acetic acid, chlorhexidine, aminoglycosides (e.g. amikacin, gentamicin, streptomycin and tobramycin), ansamycins, carbacephem, cephalosporins, glycopeptides (e.g. vancomycin), macrolides (eg clarithromycin), monobactams and sulfonamides).
    Type: Application
    Filed: January 14, 2011
    Publication date: July 4, 2013
    Inventors: Steven Lane Percival, Brian John Hamerslag
  • Publication number: 20130164362
    Abstract: A wood preservative includes injectable particles comprising one or more sparingly soluble copper salts. The copper-based particles are sufficiently insoluble so as to not be easily removed by leaching but are sufficiently soluble to exhibit toxicity to primary organisms primarily responsible for the decay of the wood. Exemplary particles contain for example copper hydroxide, basic copper carbonate, copper carbonate, basic copper sulfates including particularly tribasic copper sulfate, basic copper nitrates, copper oxychlorides, copper borates, basic copper borates, and mixtures thereof. The particles typically have a size distribution in which at least 50% of particles have a diameter smaller than 0.25 ?m, 0.2 ?m, or 0.15 ?m. At least about 20% and even more than 75% of the weight of the particles may be composed of the substantially crystalline copper salt. Wood or a wood product may be impregnated with copper-based particles of the invention.
    Type: Application
    Filed: April 13, 2012
    Publication date: June 27, 2013
    Applicant: Osmose, Inc.
    Inventors: H. Wayne Richardson, Robert L. Hodge
  • Patent number: 8460698
    Abstract: A composite article comprises a fluid transport layer having first and second surfaces and a hydrophobic layer applied to the first surface of the fluid transport layer. When the composite article is used as a wound dressing, the first surface of the fluid transport layer provides a skin-facing surface. The hydrophobic layer comprises a plurality of discontinuities, and at least a portion of the discontinuities have a dimension sufficient to permit the passage of fluid through the hydrophobic layer and into the fluid transport layer.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: June 11, 2013
    Assignee: Milliken & Company
    Inventors: Robert M. MacMeccan, Le Zhang, Keith A. Keller, Martin E. Cowan, T. Andrew Canada
  • Patent number: 8454990
    Abstract: A composite article comprises a fluid transport layer, a fluid retentive layer, and, optionally, a moisture vapor permeable film. The first surface of the fluid transport layer provides a fluid contacting surface. The fluid retentive layer is positioned so that the first surface layer of the fluid retentive layer is adjacent to the second surface of the fluid transport layer. The moisture vapor permeable film is positioned so that it is adjacent to the second surface of the fluid retentive layer. The composite article is suitable for use as a wound dressing.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: June 4, 2013
    Assignee: Milliken & Company
    Inventors: T. Andrew Canada, Martin E. Cowan, Robert M. MacMeccan, Le Zhang
  • Patent number: 8425880
    Abstract: Metal-containing materials, as well as their preparation, formulations, and use are disclosed.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: April 23, 2013
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Jeffrey B. Lyczak, Katherine Thompson, Katherine Turner, Paul Schechter
  • Patent number: 8394403
    Abstract: This disclosure relates to wound care devices which are capable of one-way, directional flow of fluids and contaminants away from the wound site to the opposite side of the wound care device, which functions as a fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess fluid, and potentially even bacteria, and is carried out without loss of physical integrity of the wound care device itself. In addition to providing a uni-directional fluid transport mechanism, the wound care device may contain a topically applied silver-based antimicrobial finish which provides certain levels of antimicrobial agent to the wound in order to clear infection from the wound site and control bacterial growth in the wound care dressing. Exemplary topical antimicrobial finishes include silver ion-releasing compounds.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: March 12, 2013
    Assignee: Milliken & Company
    Inventors: T. Andrew Canada, Martin E. Cowan, Kenneth M. Wiencek
  • Publication number: 20130039953
    Abstract: A method for treating a surface with a therapeutic agent is disclosed. The method comprises precipitating a therapeutic agent from a hydrophilic polymeric base layer with which the therapeutic agent has been complexed, to form a layer comprising microparticles of the therapeutic agent on the hydrophilic polymeric base layer, the hydrophilic polymeric base layer being grafted to the surface. Devices comprising a surface having a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface and a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer are also disclosed.
    Type: Application
    Filed: July 6, 2012
    Publication date: February 14, 2013
    Applicant: Covalon Technologies
    Inventors: Vyacheslav Dudnyk, Valerio DiTizio
  • Publication number: 20130011337
    Abstract: To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative. A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) ?-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination. R2R1NCH2COCH2CH2COR3 ??(1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 10, 2013
    Applicant: SBI PHARMACEUTICALS CO., LTD.
    Inventors: Toshihiko KUROIWA, Yoshinaga KAJIMOTO, Takahiro MASUBUCHI, Masahiro ISHIZUKA, Tohru TANAKA
  • Publication number: 20130011489
    Abstract: The present disclosure provides methods and compositions for treating fungal diseases of plants. In one embodiment, an anti-fungal aqueous composition can comprise: a nitrogen source material having a total nitrogen content in an amount of about 0.1 wt % to about 0.5 wt % of the total weight of the composition, a phosphate source material having total phosphate content in an amount of about 0.05 wt % to about 0.15 wt % of the total weight of the composition, a potassium source material with a soluble potash content in an amount of about 0.05 wt % to about 0.15 wt % of the total weight of the composition, and a sulfur source material in an amount of about 0.005 wt % to about 0.02 wt % of the total weight of the composition.
    Type: Application
    Filed: July 5, 2012
    Publication date: January 10, 2013
    Inventor: Steven R. Teerlink
  • Publication number: 20120308840
    Abstract: A formulation is claimed, which contains at least one protective substance that is active with respect to cellulose-containing materials, such as wood-containing building materials in the form of solid wood or wood-based materials, and at least one specific compound with dispersing properties. The dispersants are branched comb-shaped polymers with polyether side chains, naphthalene-sulfonate-formaldehyde condensation products, melamine-sulfonate-formaldehyde condensation products and phosphatized polycondensation products. The formulations according to the invention are suitable in particular as plant protection agents and wood preservatives and are preferably used in the form of suspensions for pressure treatment of the respective building materials.
    Type: Application
    Filed: December 13, 2010
    Publication date: December 6, 2012
    Inventors: Michael Maier, Jörg Habicht, Alexander Kraus, Andrey Karpov, Frank Rosowski, Frank Müller
  • Patent number: 8313780
    Abstract: Disclosed is a silver-based inorganic antimicrobial agent which exhibits superior heat resistance, chemical resistance, processability and long-lasting waterproofness. The present invention was completed based on the finding that the problems can be solved by a silver-based inorganic antimicrobial agent represented by the following Formula (1) containing zirconium pyrophosphate (ZrP2O7). AgaMbZrcHfd(PO4)3.nH2O??(1) (In Formula (1), M is at least one ion selected from an alkali metal ion, an ammonium ion, a hydrogen ion and an oxonium ion, a, b, c and d are positive numbers satisfying 1.75<(c+d)<2.2 and a+b+4(c+d)=9, and n is 2 or less).
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: November 20, 2012
    Assignee: Toagosei Co., Ltd.
    Inventor: Koji Sugiura