Inorganic Active Ingredient Containing Patents (Class 424/600)
  • Patent number: 10245236
    Abstract: A treatment product for a mouth-related disorder, and associated method of treatment, where the treatment product includes an initially sealed dispensing package and a composition disposed in said package, the composition including one or more vitamins, one or more amino acids, and Xylitol (a natural composition), where the composition is a liquid at room temperature and solid or substantially solid when administered to a subject's mouth.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: April 2, 2019
    Inventor: Lisa Carroll
  • Patent number: 10221152
    Abstract: The present invention relates to a use of mycophenolate mofetil or a pharmaceutically acceptable salt thereof in the manufacture of a medicament against influenza virus. The present invention also relates to a use of mycophenolate mofetil or a pharmaceutically acceptable salt thereof in the manufacture of a medicament against drug-resistant influenza virus strains. The present invention is further related to a method for treating influenza in a subject, comprising administering to said subject an effective amount of mycophenolate mofetil or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 5, 2019
    Assignee: GIANT FORCE TECHNOLOGY CORPORATION
    Inventors: An-Rong Lee, Chi-Hong Chu, Wen-Liang Chang, Chen-Wen Yao, Wen-Hsin Huang, Li-Heng Pao
  • Patent number: 10184025
    Abstract: The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 ?S/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: January 22, 2019
    Assignee: IMRA America, Inc.
    Inventors: Yuki Ichikawa, Andrius Marcinkevicus, Masayuki Ito, Wei Qian
  • Patent number: 10155093
    Abstract: A gas enriched foam generating apparatus for performing medical procedures includes a foam generating tip assembly composed of a multi-channel arrangement at a proximal first end thereof and a tip at a distal second end thereof. The apparatus also includes a compressed gas unit fluidly connected to the multi-channel arrangement at a proximal first end of the foam generating tip assembly and a medical solution fluidly connected to the multi-channel arrangement at a proximal first end of the foam generating tip assembly. Compressed gas, from the compressed gas unit, and the medical solution are combined within the foam generating tip assembly in a manner generating a gas enriched foam that is ultimately dispensed from the foam generating apparatus.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: December 18, 2018
    Inventors: Frank Levy, Kimberley Levy
  • Patent number: 10098930
    Abstract: A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: October 16, 2018
    Assignee: Ascendis Pharma Endocrinology Division A/S
    Inventors: Harald Rau, Susanne Kindermann, Torben Lebmann, Grethe Norskov Rasmussen, Ulrich Hersel, Thomas Wegge, Kennett Sprogoe
  • Patent number: 10030039
    Abstract: [Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a complex produced by making a metal-salen complex compound, which includes a central metal and (N, N, O, O) as a quadridentate ligand and is magnetic, bind to taxane molecules which are anticancerous; and the anticancer agent is to kill cancer cells regarding which phase transition of its cell cycle occurs between phases including Gap1, Synthesis, Gap2, and Mitosis and Cytokinesis. The present disclosure is suited for use to kill cancer cells of breast cancer and, particularly, cancer cells of triple-negative breast cancer. The present disclosure is designed to make the anticancer agent contact the cancer cells in two or more continuous phases selected from a group consisting of Gap1, Synthesis, Gap2, and Mitosis and Cytokinesis and kill the cancer cells.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: July 24, 2018
    Assignees: IHI Corporation
    Inventors: Yoshihiro Ishikawa, Haruki Eguchi
  • Patent number: 10016504
    Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 10, 2018
    Assignee: NORGINE BV
    Inventors: Lucy Clayton, Alasdair Cockett, Mark Christodoulou, Ian Davidson, Lynn Farrag, Marc Halphen, Leighton Jones, Vanik Petrossian, Peter Stein, David Tisi, Alex Ungar, Jeffrey Worthington
  • Patent number: 9980489
    Abstract: The present invention relates to dissolved silicate compositions in which the dissolved silicate is stabilized by at least two selected osmolytes and is therefore bioavailable. The composition and its dilutions are stable over a long period of time and are used in a wide field of applications for the benefit of living organisms such as plants, animals and humans.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: May 29, 2018
    Assignee: Taminco BVBA
    Inventors: Peter Roose, Marc Demuynck, Johan De Saegher, Jean-Michel Rabasse
  • Patent number: 9925218
    Abstract: Embodiments of the invention relate to a composition, method and kit for producing galvanic cells upon application of the composition to the skin. In some embodiments, the composition comprises encapsulated half-galvanic cell units (e.g. individual and/or autonomous half-galvanic cell units) having the same ox/red potential (E°), wherein each half-galvanic cell unit comprises metal particles in the range of nano- to micro size or a mixture thereof, suspended within an aqueous solution of soluble electrolytic salt of same metal and wherein each half-galvanic cell unit is encapsulated by internal layer(s) made of hydrophilic metal (including silicon) oxide nanoparticles and external layer(s) made of hydrophobic metal (including silicon) oxide nanoparticles. The composition is useful for preventing and/or treating alopecia or for enhancing hair growth.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: March 27, 2018
    Assignee: PILOGICS L.P.
    Inventors: Dov Ingman, Erez Manor
  • Patent number: 9918476
    Abstract: A method for manufacturing a parasiticidal composition comprising at least 40% of alkali metal bicarbonate and at least 1% of silica, wherein: at least 35% of the alkali metal bicarbonate of the composition is milled in the presence of silica in order to form a mixture of particles, and if necessary, the remainder of the alkali metal bicarbonate is added to the mixture of particles to form the parasiticidal composition, and wherein said parasiticidal composition has a particle size distribution such that at least 50% by weight of the particles have a diameter of less than 100 ?m. A parasiticidal composition obtained by the present method and the use of the parasiticidal composition obtained by the present method in the form of a powder, a suspension or a gel.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: March 20, 2018
    Assignee: Solvay SA
    Inventor: Jean-Philippe Pascal
  • Patent number: 9889237
    Abstract: A medical device has a surface intended for contact with living tissue, wherein the surface comprises nanoparticles comprising a non-toxic post-transition metal such as gallium and/or bismuth, said nanoparticles having an average particle size of 500 nm or less. The nanoparticles may provide an antimicrobial effect, and thus the risk for infection may be reduced.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: February 13, 2018
    Assignee: DENTSPLY SIRONA Inc.
    Inventors: Anna Arvidsson, Ingela Mattisson, Elisabet Ahlberg, Johanna Löberg
  • Patent number: 9855234
    Abstract: The present invention is directed to diclofenac sublingual spray formulations. The present invention is also directed to methods for treating pain and inflammation by administering the formulations of the present invention to patients in need thereof.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: January 2, 2018
    Assignee: INSYS DEVELOPMENT COMPANY, INC.
    Inventors: Kiran Kumar Vangara, Daniela Bockenstedt, Ningxin Yan, Rajesh Pandya, Venkat R. Goskonda
  • Patent number: 9833471
    Abstract: A sanitizing formulation is disclosed for use as a hand sanitizer. The formulation may include hypochlorous acid, a silicone polymer or blend thereof, sodium phosphate, hydrochloric acid, and sodium magnesium silicate. Methods of using and making the sanitizing formulation are also disclosed.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: December 5, 2017
    Assignee: Reoxcyn Discoveries Group, Inc.
    Inventors: Kurt Richards, Andrew Hoover
  • Patent number: 9808555
    Abstract: Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: November 7, 2017
    Assignee: University of South Carolina
    Inventor: Esmaiel Jabbari
  • Patent number: 9757397
    Abstract: Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (API) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition. The pre-mixing of constituents may increase the stability of the API and provide uniformity of the dispersion of the constituents throughout the final topical composition.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: September 12, 2017
    Assignee: Novan, Inc.
    Inventors: Eleftherios Kougoulos, Nathan Stasko
  • Patent number: 9757346
    Abstract: The invention provides methods of treatment that induce satiety in a subject for a period of at least around twenty-four hours by once-daily administration to the subject of a controlled release dosage form, wherein the dosage form is administered while the subject is in the fasted state and at a time of around six to around nine hours prior to the subject's next intended meal, and wherein the dosage form comprises a controlled release composition, which comprises an enterically-coated, ileum hormone-stimulating amount of a nutritional substance and releases the majority of the nutritional substance in vivo upon reaching the subject's ileum. The invention also provides a diagnostic tool for probing the health and disease state of the ileal hormones, excess or deficiencies. The invention provides a safe vehicle for targeted deliveries of chemical, pharmaceuticals, natural substances and nutrition to the ileum.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: September 12, 2017
    Assignee: VOLANT HOLDINGS GMBH
    Inventor: Joseph M. Fayad
  • Patent number: 9732464
    Abstract: A method for producing water repellent down includes soaking cleaned down in an aqueous solution having a pH ranging from 4 to 7; adding to the solution a cross-linking agent composed of a material having an isocyanate or acrylic acid functional group to provide a solution having a weight ratio of the down and the cross-linking agent ranging between 1:0.005 and 1:0.06; adding to the solution a water-drawing agent composed of a material having a siloxane functional group to provide a solution having a weight ratio of the down and the water-drawing agent ranging between 1:0.01 and 1:0.1; stirring the solution for at least 15 minutes to react the cross-linking agent and the water-drawing agent and form a water repellent layer on the surface of the down; separating the down from the solution; and oven drying the down with hot air having a temperature of at least 120° C.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: August 15, 2017
    Assignee: KWONG LUNG ENTERPRISE CO., LTD.
    Inventor: Chang-Cheng Chen
  • Patent number: 9723834
    Abstract: The present invention relates to a composition comprising a pyripyropene pesticide of the formula (I) or (II) as defined below and a base. The present invention relates also to methods of preparing and applying such compositions, as well as several uses thereof, and finally seeds, comprising said composition.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: August 8, 2017
    Assignee: BASF SE
    Inventors: Cedric Dieleman, Torsten Knieriem, Michael Krapp, Paul Ch. Kierkus, Wen Xu, Kara Benton
  • Patent number: 9669203
    Abstract: Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include administering vesicles having a nucleating agent and a therapeutic drug to a vascular system of a patient, and providing an active interval of ultrasonic exposure substantially throughout a targeted treatment zone. The ultrasonic exposure is produced by a source transducer at a specified fundamental frequency, amplitude, duty cycle, and duration. The methods also include detecting a scattered ultrasonic wave, where the scattered ultrasonic wave is received by a detection transducer. Detection of the scattered ultrasonic wave is indicative of stable and/or inertial cavitation. The ultrasonic exposure is provided intermittently in the active intervals separated by rest periods, and substantially less ultrasonic exposure is provided during the rest period than during the active interval.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: June 6, 2017
    Assignee: University of Cincinnati
    Inventors: Christy K. Holland, Kathryn E. Hitchcock, Kevin Haworth, Nikolas Ivancevich, T. Douglas Mast
  • Patent number: 9663691
    Abstract: Methods and systems are provided for producing ionized alkaline solutions (e.g. ionized alkaline water) that exhibit long-term stability when stored at room temperature.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: May 30, 2017
    Assignee: Electrolyzed Innovations, LLC
    Inventor: Philip Adams
  • Patent number: 9545429
    Abstract: Homeopathic compositions. Implementations of topical homeopathic compositions may include an actives portion including a plurality of active ingredients and a base including a plurality of inactive ingredients where the plurality of active ingredients include tinctures and/or homeopathic preparations of Actaea spicata, Aesculus hippocastanum, Arnica montana, Atropa belladonna, Bellis perennis, Bryonia alba, Calendula officinalis, Causticum, Cimicifuga racemosa, Hypericum perforatum, Kali Carbonicum, Ledum palustre, Lithium Carbonicum, Rhododendron chrysanthum, Rhus toxicodendron, Ruta graveolens, Salicylicum Acidum, and Stellaria media and one or more tinctures and/or homeopathic preparations selected from the group consisting of Althaea officinalis, Caulophyllum thalictroides, Guaiacum, Rhamnus californica, or any combination thereof.
    Type: Grant
    Filed: September 3, 2011
    Date of Patent: January 17, 2017
    Assignee: BIOLYTE LABORATORIES, LLC
    Inventor: Daniel J. Kaline
  • Patent number: 9468779
    Abstract: The invention relates to a polysaccharide gel of natural origin for dermatological use that comprises an aqueous solution of the polysaccharide of 0.1 to 5% by weight/volume, for example hyaluronic acid, and a viscous and strongly hydrophilic biocompatible alcohol at 0.5-5% by weight/volume, for example glycerol, and optionally the adjuvants that are commonly used in dermatology. The gel is prepared by mixing the polysaccharide solution and the strongly hydrophilic viscous alcohol before sterilizing the entire mixture by, for example, moist heat.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: October 18, 2016
    Assignee: ANTEIS SA
    Inventor: Gilles Bos
  • Patent number: 9446079
    Abstract: A composition of medical grade honey and silver nitrate is described for treatment of burns, ulcers, and open wounds. The disclosed composition is a gel of medical grade honey and silver nitrate in a ratio of about 211 to 1, with a moisture level of no greater than 20 percent and wherein the medical grade honey contains about 300 kg/mg of methylglyoxal. Also described are methods of making and using the honey and silver nitrate mixture for treatment of burns, ulcers and wounds including direct application to a treatment area as well as impregnating a gauze fabric with a composition of medical grade honey and silver nitrate for application to a treatment area.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: September 20, 2016
    Assignee: Links Medical Products, Incorporated
    Inventors: Thomas L. Buckley, Andrew Thain
  • Patent number: 9427411
    Abstract: The present invention relates to an antimicrobial topical composition and process for making such composition. The composition comprises of ionic silver, silver nanoparticles, and oxygen, combined within a gel medium and applied topically. The composition optimizes the ionic silver and silver nanoparticle ratio providing for sufficient ionic silver to be delivered as an immediate antimicrobial agent, and sufficient nanoparticle silver to provide time release for conversion to silver ions for continuing antimicrobial effectiveness.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: August 30, 2016
    Inventor: JoAnna M. Esty
  • Patent number: 9421226
    Abstract: The present invention provides methods for maintaining electrolyte balance and hydration in a person habituated to strenuous physical exertion by assaying perspiration generated by the person under conditions of strenuous physical exertion to determine the volume of perspiration as a function of duration of exertion and the sodium content of the person's perspiration during strenuous physical exertion The person is assigned to one of a plurality of groups of individuals, each group differing in the amount of sodium present in the perspiration and having a unique rehydration solution. The invention also provides for a set rehydration compositions, each member of the set comprising sodium and chloride differing from the weight percentage of sodium in the other members of the set and each member of the set being perceptually labeled to distinguish that member from the other members of the set by one of the human senses.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: August 23, 2016
    Assignee: Heat Sport Sciences, Inc.
    Inventors: Arthur R. Bartolozzi, Sandra Fowkes Godek
  • Patent number: 9333224
    Abstract: The present invention relates to compositions comprising a silicate and methods of use thereof. In particular, the compositions of the present invention are suitable for treating inflammatory conditions, cancer, bacterial and viral infections, and infected and uninfected wounds. The compositions of the present invention can also be useful in treating spinal cord injury, tissue remodeling, and promoting bone growth and repair.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: May 10, 2016
    Assignee: HS PHARMACEUTICALS, LLC
    Inventors: Richard Thomas Stanley, Sr., David Edward Stanley, Marcus Blackstone, Thomas Wagner
  • Patent number: 9332760
    Abstract: A substrate contains a composition including VOSO4, K11H[(VO)3(SbW9O33)2], Na9[SbW9O33], oxacillin and 5-chloro-2-(2,4-dichlorophenoxy)phenol.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: May 10, 2016
    Assignee: VB JAPAN TECHNOLOGY CO., LTD.
    Inventors: Katsuaki Dan, Toshihiro Yamase, Hiromichi Ichikawa
  • Patent number: 9314549
    Abstract: Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: April 19, 2016
    Assignee: University of South Carolina
    Inventor: Esmaiel Jabbari
  • Patent number: 9295254
    Abstract: A method of treating soils to eradicate or reduce the proliferation of nematodes said method comprising the application of select metal ion-acid compositions to the soil.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: March 29, 2016
    Assignee: SCIESSENT LLC
    Inventor: Naseem Khan
  • Patent number: 9232804
    Abstract: The present invention includes a composition for sterilizing a bioscaffold, comprising slightly acidic electrolyzed water (SAEW) as an active ingredient, and a method for sterilizing a bioscaffold using the same. The slightly acidic electrolyzed water according to the present invention has excellent effects on the sterilization of bioscaffolds and the removal of immunogenic antigens and a little effect on extracellular matrix, such as glycosaminoglycans or collagen. Moreover, the scaffold sterilized with the slightly acidic electrolyzed water has excellent cell attachment and has no toxicity, and thus the slightly acidic electrolyzed water can be effectively used for the sterilization of bioscaffolds.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: January 12, 2016
    Assignee: KNU University-Industry Cooperation Foundation
    Inventors: Heung Myong Woo, Kyung Mee Park, Kamal El Din Hany Hussein
  • Patent number: 9173899
    Abstract: Method of treating autistic spectrum disorder includes administration to a person of a product, which contains stable water clusters, such as stable double helix water clusters, by taking the products by mouth, applying the products on a skin of the person, intaking the product by breathing, introducing the products intravenously, etc.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: November 3, 2015
    Assignee: D & Y Laboratories Inc.
    Inventors: Shui Yin Lo, David L. Gann
  • Patent number: 9132100
    Abstract: The present invention is directed to a patch containing a non-steroidal anti-inflammatory drug including an adhesive layer composed of a transdermal preparation on a support, the transdermal preparation including a) 10 to 40% by weight of a nonaqueous base material based on the total weight of the transdermal preparation, b) 1 to 10% by weight of a non-steroidal anti-inflammatory drug based on the total weight of the transdermal preparation, and c) a polyethylene glycol component composed of 0.3 to 5% by weight of a low molecular weight polyethylene glycol based on the total weight of the transdermal preparation, and 1 to 10% by weight of a high molecular weight polyethylene glycol based on the total weight of the transdermal preparation.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: September 15, 2015
    Assignee: Reckitt Benckiser Healthcare International Limited
    Inventors: Naoki Murai, Seijiro Yama
  • Patent number: 9119395
    Abstract: The invention relates to novel biocidal active substance mixtures containing o-phenylphenol and amines, methods for the production thereof, the use thereof for protecting technical materials and products from being infested and destroyed by microorganisms, and microbicidal agents based on said novel mixtures.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: September 1, 2015
    Assignee: LANXESS Deutschland GmbH
    Inventors: Peter Wachtler, Martin Kugler
  • Patent number: 9089511
    Abstract: Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: July 28, 2015
    Assignee: REVEN PHARMACEUTICALS, INC.
    Inventors: Henk Van Wyk, Mariette Van Wyk, Trace Krebs, Peter Lange, Brian Denomme, Michael A. Volk
  • Patent number: 9028851
    Abstract: The present invention is directed to a hemostatic material comprising a scaffold and a galvanic particulate. The galvanic particulate comprises particles made of at least two dissimilar metals. The scaffold is preferably a biocompatible polysaccharide-based hemostatic, such as a chitosan or cellulosic based hemostatic like ORC.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: May 12, 2015
    Assignee: Ethicon, Inc.
    Inventors: Yi-Lan Wang, Ying Sun, Guanghui Zhang, Chunlin Yang
  • Publication number: 20150118180
    Abstract: Formulations containing reactive oxygen species (ROS), processes for making these formulations, and methods of using these formulations are described. The formulations can include gels or hydrogels that contain at least one reactive oxygen species (ROS). The formulations can include a composition containing a reduced species (RS) and a reactive oxygen species (ROS). The formulations can also contain a rheology modifier and can include gels or hydrogels. Methods of preparing the formulations can include preparing a composition. Compositions can be prepared by providing water, purifying the water to produce ultra-pure water, combining sodium chloride to the ultra-pure water to create salinated water, and electrolyzing the salinated water at a temperature between about 4.5 to about 5.8° C.
    Type: Application
    Filed: October 24, 2014
    Publication date: April 30, 2015
    Applicant: REOXCYN DISCOVERIES GROUP, INC.
    Inventor: Andres Hoover
  • Patent number: 9011931
    Abstract: A composition used to facilitate healing of cold sores, fever blisters and canker sore that includes potassium, rubidium, zinc, calcium and sodium is provided. This composition is compounded into a polyethylene glycol ointment containing allantoin (0.5 to 2 percent) and camphor (0.1 to 3 percent) and/or menthol (0.1 to 1 percent). In another embodiment, a method to treat cold sores, fever blisters and canker sores is provided by applying an effective amount of this composition to cold sores, fever blisters and canker sores of a subject in need of treatment thereof.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: April 21, 2015
    Inventors: Libby Robinson, Mikel Hays
  • Patent number: 9011888
    Abstract: Organic-inorganic composite particles includes inorganic oxide particles each of which has a cationic charge on the particle surface and polymer gel molecules which are derived from a natural substance, have an anionic functional group and one or more hydroxyl groups in a molecule and have both a shrinking and a swelling property, the polymer gel molecules are electrostatically bonded to surfaces of the inorganic oxide particles; a process for producing the particles; a dispersion containing the particles; and a cosmetic containing the particles. These organic-inorganic composite particles have good dispersibility not only in aqueous solvents such as water but also in non-aqueous solvents and further have characteristics that aggregation of the particles scarcely occurs.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 21, 2015
    Assignee: JGC Catalysts and Chemicals Ltd.
    Inventors: Kensuke Nagata, Michio Komatsu
  • Publication number: 20150104524
    Abstract: Lightweight, small, portable devices and methods are disclosed that provide oxygen-enriched air using an ultra rapid adsorption cycle based on advanced molecular sieve materials.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 16, 2015
    Inventors: Stephen Douglas Galbraith, David K. Walker, Kenneth J. McGowan, Elise N. DePetris, Judith C. Galbraith
  • Patent number: 8999313
    Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods an kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: April 7, 2015
    Assignee: Norgine BV
    Inventors: Lucy Clayton, Alasdair Cockett, Mark Christodoulou, Ian Davidson, Lynn Farrag, Marc Halphen, Leighton Jones, Vanik Petrossian, Peter Stein, David Tisi, Alex Ungar, Jeffrey Worthington
  • Publication number: 20150093448
    Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Angiopoietin-related protein 3, Soluble Lymphatic vessel endothelial hyaluronic acid receptor 1, and Vascular endothelial growth factor D as diagnostic and prognostic biomarkers in renal injuries.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 2, 2015
    Applicant: ASTUTE MEDICAL, INC.
    Inventors: Joseph Anderberg, Jeff Gray, Paul McPherson, Kevin Nakamura, James Patrick Kampf
  • Patent number: 8992998
    Abstract: A method of treating inflammation in a subject by administering a composition including hydrogen, releasing hydrogen in the subject, suppressing mitogen-activated protein kinase (MAPK) phosphorylation and upregulating expression of MKP-1, and down-regulating inflammatory responses of monocyte lineage cells.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: March 31, 2015
    Inventors: Toshihisa Kawai, Mikihito Kajiya, Kimihiro Sato
  • Publication number: 20150086523
    Abstract: The invention is dietary supplements, nutraceutical compositions, medical foods, and animal feeds that have cytoprotective (cell and tissue protection) and health promoting effects. The compositions contain a high dose range of agmatine and nutraceutical acceptable salts thereof as dietary fortification for providing effective long-term cytoprotection and affording for soft stool. The compositions may contain agmatine alone or in combination with other dietary ingredients having health promoting effects. The compositions can be prepared with dietary accepted excipients and compatible forms of carriers, including but not limited to, powders, tablets, capsules, controlled release carriers, lozenges and chewable preparations, liquid suspensions, suspensions in an edible supporting matrix or foodstuff and oral rehydration solutions, to enable consumption of said compositions.
    Type: Application
    Filed: December 1, 2014
    Publication date: March 26, 2015
    Inventors: Gad Gilad, Varda Gilad
  • Publication number: 20150079197
    Abstract: An object of the present invention is to provide a medicine for general anesthesia which can prevent and/or alleviate an anesthetic-induced neurological deficit in the brain (preferably in the developing brain). The present invention relates to a medicine which comprises a combination of a general anesthetic and hydrogen and can prevent and/or alleviate an anesthetic-induced neurological deficit in the brain (preferably in the developing brain).
    Type: Application
    Filed: May 30, 2013
    Publication date: March 19, 2015
    Applicant: MARUISHI PHARMACEUTICAL CO., LTD.
    Inventors: Tomiei Kazama, Yasushi Satoh, Ryuji Yonamine
  • Publication number: 20150064276
    Abstract: A method for the dietary management of anxiety includes administering to a subject in need thereof water containing from 0.0002 to 0.0278 mol. % of isotopologue HOD, preferably, from 0.0178 to 0.0278 mol. % of isotopologue HOD.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 5, 2015
    Inventors: Igor Anatolyevich Pomytkin, Anton Sergeevich Chernopyatko
  • Publication number: 20150064277
    Abstract: A medical food for the dietary management of anxiety includes water containing from 0.0002 to 0.0278 mol. % of isotopologue HOD, preferably, from 0.0178 to 0.0278 mol. % of isotopologue HOD.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 5, 2015
    Inventors: Igor Anatolyevich Pomytkin, Anton Sergeevich Chernopyatko
  • Publication number: 20150064256
    Abstract: The invention provides porous carbon particles for use in the treatment or prevention of liver disease, wherein at least 20% of the total pore volume is made up of pores having a mean diameter of from 2 to 200 nm and/or wherein the particles comprise micropores of diameter 2 nm or less and small macropores of diameter 50 nm to 500 nm, but substantially no mesopores of diameter greater than 2 nm and less than 50 nm, and substantially no large macropores of diameter greater than 500 nm.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 5, 2015
    Inventors: Carol Angela Howell, Sergey Victorovich Mikhalovsky, Susan Rachel Sandeman, Rajiv Jalan, Jane MacNaughtan
  • Publication number: 20150064229
    Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Inventors: Charanpreet S. BAGGA, Steve B. JUNG, Hyun W. BAE
  • Publication number: 20150064275
    Abstract: Compositions and methods for improving transperitoneal oxygen uptake during peritoneal ventilation for extrapulmonary oxygenation of an organism or individual organs in preferably life-threatening case of need, such as pulmonary failure or circulatory shock, are disclosed. Such deficiencies can be addressed by transperitoneal administration of oxygen via a gas introduced into the abdominal cavity. A liquid, preferably aqueous, composition including an oxygen carrier such as hemoglobin is used, which, surprisingly, is capable of increasing the effectiveness of the diffusion of the oxygen administered by a one-time or repeated filling or continuous flushing of the abdominal cavity. An oxygen carrier, such as hemoglobin or derivatives thereof, is used for the manufacture of a composition for improvement of the diffusion of oxygen (gas) introduced into mucus layers of the peritoneum, preferably to enhance the diffusion of oxygen in transperitoneal ventilation.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 5, 2015
    Applicant: SANGUI BIOTECH INTERNATIONAL, INC.
    Inventors: Harald POETZSCHKE, Hubertus SCHMELZ
  • Patent number: 8968792
    Abstract: The present invention relates to a pharmaceutical combination for the treatment of renal failure in pets, caused by various diseases or ineffective to traditional renal therapy or renal replacement therapy thereby incapable of restoring health. The pharmaceutical combination of the present invention is administered by subcutaneous injection to pets in need thereof, with various advantages including simple use, no requirement for surgery, hospitalization and/or fluid infusion, faster recovery of health status, reduced medical costs, significantly improved recovery rate, reduced mortality and the likes. The pharmaceutical combination of the present invention can also be used for the continuous care treatment of pets with renal failure.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 3, 2015
    Inventor: Cheng Yi Lin