Phosphorus Acid Patents (Class 424/605)
  • Patent number: 6541421
    Abstract: This invention relates to a buffered phosphorus containing solution comprising at least one phosphorus compound selected from the group consisting of phosphorous acid, hypophosphorous acid, polyphosphorous acid polyhypophosphorous acid, and salts thereof. The solution also contains a buffer including an organic base in the form of a nitrogen containing compound and its conjugate acid. The solution may be used as a fertilizer or as a fungicide. The invention also relates to a method of preparing such a solution.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: April 1, 2003
    Inventors: Alastair James Forsyth, Tomasz Antoni Modro
  • Patent number: 6538038
    Abstract: Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: March 25, 2003
    Assignee: OXiGENE, Inc.
    Inventors: Ronald W. Pero, David Sherris
  • Patent number: 6524624
    Abstract: A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid and an optional oxidizable colorant, and wherein the first part, the second part, or both the first and second parts comprise an alpha olefin sulfonate.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: February 25, 2003
    Assignee: Alcide Corporation
    Inventors: Joseph Morelli, C. Cayce Warf, Jr., Maura Aldrich, Cecilia Moser Morse, Jean Wiley
  • Publication number: 20030035847
    Abstract: A composition and therapeutic methods therefore for pharmacologically strong acid solutions comprising a mixture of strong and weak acids.
    Type: Application
    Filed: April 2, 2002
    Publication date: February 20, 2003
    Inventor: David Martucci
  • Patent number: 6521264
    Abstract: A solid powder product with a Ca/P ratio of between 1.40 and 1.90 is prepared from tricalcium phosphate and tetracalcium phosphate. An aqueous solution containing calcium ions and phosphate ions with a Ca/P ratio higher than 0.20 and lower than 0.50 is prepared. The aqueous solution and the solid powder product and optionally water are mixed to obtain a mixture with a liquid/solid weight ratio of between 0.30 and 0.65 and a resulting paste with a Ca/P ratio of between 1.50 and 1.67.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: February 18, 2003
    Assignee: Teknimed
    Inventors: Jean-Louis Lacout, Zinèb Hatim, Michele Frache-Botton
  • Patent number: 6509041
    Abstract: A fungicidal composition for plants containing phosphonate (PO3) and phosphate (PO4) salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a Phytophthora infestans infection in plants.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: January 21, 2003
    Assignee: Foliar Nutrients, Inc.
    Inventor: John B. Taylor
  • Publication number: 20020192297
    Abstract: An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H202 and as-used concentrations contain about 0.5 % wt./wt. % H202. The solution also contains from 0.05 to 8.0 wt./wt. % of at least one phosphorous-based acid, e.g. phosphoric acid and/or a phosphonic acid with from 1 to 5 phosphonic acid groups, and from 0.02 to 5 wt./wt. % of at least one anionic surfactant. The surfactant is selected from C8 to C16 alkyl aryl sulfonic acids, sulfonated C12 to C22 carboxylic acids, C8 to C22 alkyl diphenyl oxide sulfonic acids, naphthalene sulfonic acids, C8 to C22 alkyl sulfonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulfates, and mixtures thereof. Most preferably the solution has an emulsifier and/or hydrotrope, e.g. an alkylated sulfonated diphenyl oxide salt, an alkyl aryl polyoxyethylene surfactant, and/or a polyoxyethylene surfactant.
    Type: Application
    Filed: December 28, 2001
    Publication date: December 19, 2002
    Inventors: Jose A. Ramirez, Michael J. Rochon
  • Publication number: 20020182264
    Abstract: The invention relates to solutions containing acidic compositions that have a pH of less than 1, are non-caustic to human tissue and are safe for human ingestion. These compositions may be used as the sole or major component of solutions such as cleansers, pharmaceuticals, food preservatives and disinfectants. The acidic compositions may be used in medical, industrial, military and household applications. The invention also relates methods of administering and using the acidic compositions of the invention.
    Type: Application
    Filed: April 9, 2002
    Publication date: December 5, 2002
    Inventors: Ernest G. Roden, John R. Dankert
  • Publication number: 20020177624
    Abstract: A composition of matter comprising a pH buffering system comprising a combination of lactic acid and related base salt that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina. The composition my include a gel form, and also contain acetic acid as well as polyethylene glycol, glycerol and oxyquinoline.
    Type: Application
    Filed: March 16, 2001
    Publication date: November 28, 2002
    Inventors: Calvin Hanna, Lindley A Cates
  • Patent number: 6476069
    Abstract: A composition useful as an embolic agent that selectively creates an embolic blockage in the lumen of a blood vessel, duct, fistula or other like body passageways by combining a monomer component and a second component wherein, said monomer component comprises of a alkyl cyanoacrylate monomer and at least one inhibitor agent; and said second component that functions as an opacificant agent and a polymerization retardant.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: November 5, 2002
    Assignee: Provasis Therapeutics Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6476070
    Abstract: A composition comprising of a monomer component comprised of at least one alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed from an alkyl cyanoacrylate monomer, an alkyl esterified fatty acid and an opacificant agent where said composition forms a resultant aggregate structure when said composition contacts an anionic environment. The compositions are useful for filling, occluding, partially filling or partially occluding an unfilled volume or space in a mass in an anionic environment. The composition are also useful for ablating diseased or undesired tissue by cutting off the blood supply to the tissue.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: November 5, 2002
    Assignee: Provasis Therapeutics Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6455075
    Abstract: A method for control of insects on plant tissue which includes applying a solution tht includes hydrogen peroxide to the plant tissue. The hydrogen peroxide solution has a concentration of between 0.05 to 3.00%. In some cases the hydrogen peroxide solution has a concentration of between 0.05 and 1.5%. Some forms of the invention may utilize a hydrogen peroxide solution that further includes an acid selected from the group consisting of acetic acid and phosphoric acid. Various structures are used for applying the hydrogen peroxide solution such as hydraulic spraying, misting, fogging, or injecting the hydrogen peroxide into a commercial cooling system. In some cases the hydrogen peroxide solution is applied to the plant tissue at a variety of stages in the plant production cycle. Other application of the invention include applying misting the hydrogen peroxide solution over terminal stem cuttings until they reach root sufficiency.
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: September 24, 2002
    Inventor: Rene N. Larose
  • Patent number: 6448240
    Abstract: The invention concerns a synergetic fungicide and/or bactericide composition comprising famoxadone and a phosphorous acid derivative; and a method for fighting, for cure or prevention, against phytopathogenic fungi and/or bacteria using such a composition.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: September 10, 2002
    Assignee: Aventis CropScience, S.A.
    Inventors: Bernadette Givois, Marie-Pascale Latorse
  • Patent number: 6436444
    Abstract: The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material and can be immediately contacted with the target animals. The .compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: August 20, 2002
    Assignee: Ecolab Inc.
    Inventors: Francis L. Richter, Cathy M. Paquette, Richard K. Staub
  • Patent number: 6423348
    Abstract: What is shown is an animal blood anticoagulant compound useful in the meat packing industry generally, and in slaughterhouse operations, particularly. The anticoagulant is effective when diluted with water at higher dilution ratios than earlier anticoagulants. In some field trials, this anticoagulant was at least as effective as previously known commercial anticoagulants when diluted by an additional 30%. The present anticoagulant preparation concentrate is an aqueous mixture of soft water (55.0%-65.0/%, w/w); tetrasodium ethylene diamine tetraacetate (Na4EDTA) (0.5%-3.0%, w/w); sodium hexametaphosphate (17.0%-24.0%, w/w); citric acid (5.0%-9.0%, w/w); and sodium hydroxide (4.0%-7.0%, w/w) to obtain a balanced pH that provides optimal chelating and anticoagulant activity. Optimal anticoagulant performance has been found to occur in the range of between pH 6.6 and pH 7.2.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: July 23, 2002
    Inventor: James C. Mickus
  • Publication number: 20020058072
    Abstract: A method of increasing vaginal lubrication in an adult human female by orally administering to the female an effective amount of an acidic solution having a pharmaceutically acceptable water-soluble iodide salt, wherein hydriodic acid is generated in situ.
    Type: Application
    Filed: October 26, 2001
    Publication date: May 16, 2002
    Inventor: Susann Reilly
  • Publication number: 20020048609
    Abstract: A fungicidal composition for plants containing phosphonate (PO3) and phosphate (PO4) salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a Phytophthora infestans infection in plants.
    Type: Application
    Filed: September 18, 2001
    Publication date: April 25, 2002
    Inventor: John B. Taylor
  • Patent number: 6368610
    Abstract: A disinfecting composition which is bactericidal and effective to kill yeast includes (a) at least one a monocarboxylic acid of formula R—COOH, in which R a saturated or unsaturated, straight- or branched-chain alkyl radical comprising from 6 to 12 carbon atoms; (b) a strong inorganic acid; (c) at least one organic acid of formula R′CH2—CO2H, in which R′ is H or OH; (d) at least one anionic surfactant; (e) at least one solubilizing agent consisting of a compound of formula R″O(CH2CH2O)x—H, in which R″ represents a C2 to C6 alkyl radical, x represents an integer from 1 to 3; and (f) water.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: April 9, 2002
    Assignee: SOPURA S.A.
    Inventors: Nicolas Velings, Ferdinand Herman, Paul-Eric Loncin
  • Patent number: 6358938
    Abstract: Synergistic fungicidal composition comprising propamocarb and a derivative of phosphorous acid; and process for the curative or preventative control of phytopathogenic fungi by use of such a composition.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: March 19, 2002
    Assignee: Rhone-Poulenc Agro
    Inventors: Joëlle Donnadieu, Patrice Duvert, Richard Mercer
  • Patent number: 6350474
    Abstract: The invention deals with phosphate water solution with cold solidification capacity. Phosphate composition containing iron oxide solution in acid, water, advantages from the following properties; it contains orthophosphorus acid and in addition metal powder. Phosphate composition is ecologically pure product, non toxic, non cancerogenic, non-allergic. It has antimicrobial, antivirus and fungicidal properties. Phosphate composition can be applied within medicine: surgery, dermatology, dentistry, oncology, pharmacology and other branches. In agriculture use: as a means of curing plant diseases, within veterinary—as a means for preventive maintenance and curing of animal diseases, within construction—as an anticorrosive, fire-resistant, hydro-electric isolating covers, ceramic tiles, concretes, which protect against radiation, as well as for producing other composite materials.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: February 26, 2002
    Inventors: David Dzneladze, Andro Dzneladze, Nargisa Jabishvili
  • Patent number: 6346279
    Abstract: An acidic aqueous hydrogen peroxid solution is provided, with improved disinfectant activity. Concentrated solutions preferably contain up to about 8% and as-used concentrations contain about 0.5% peroxide. The solution also contains from 0.1 to 5.0% of at least one acid compound, e.g. phosphoric and/or a phosphonate with from 1 to 5 phosphonic acid groups, and from 0.02 to 5% of at least one anionic surfactant. The surfactant is selected from C8 to C16-alkyl aryl sulphonic acids, sulphonated C12 to C22 carboxylic acids, C8 to C22-alkyl diphenyl oxide sulphonic acids, naphthalene sulphonic acids, C8 to C22 alkyl sulphonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulphates, and mixtures thereof. Most preferably the solution has an emulsifier, e.g. a salt of an alkylated diphenyl oxide. The solution may also contain corrosion inhibitors and/or lower alcohols.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: February 12, 2002
    Assignee: Virox Technologies, Inc.
    Inventor: Michael J. Rochon
  • Patent number: 6344218
    Abstract: The present invention relates to aqueous compositions comprising an odor controlling agent and select sanitizing agents for deodorizing and sanitizing skin surfaces. Articles of manufacture and methods of deodorizing and sanitizing the skin using disclosed compositions are also disclosed.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: February 5, 2002
    Assignee: The Procter & Gamble Company
    Inventors: Michael Thomas Dodd, Karl Shiqing Wei, Toan Trinh, Mark Richard Sine, Robert Gregory Bartolo, David Andrew Jakubovic
  • Patent number: 6338860
    Abstract: A fungicidal composition for plants containing phosphonate (PO3) and phosphate (PO4) salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a Phytophthora infestans infection in plants.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: January 15, 2002
    Assignee: Foliar Nutrients, Inc.
    Inventor: John B. Taylor
  • Patent number: 6303155
    Abstract: A method for restoration of the circadian rhythm of parathyroid hormone (PTH) serum levels in a subject having osteoporosis, so as to restore a circadian rhythm of PTH levels which is similar to that existing in normal subjects is disclosed by administering a single daily dose of a composition consisting essentially of an effective amount of phosphate in the evening or at night, whereby the composition causes a circadian rhythm of PTH levels which peaks during the night, whereby the circadian rhythm of PTH levels is restored to that which is similar to that existing in normal subjects, thereby treating osteoporosis.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: October 16, 2001
    Assignee: Hadasit Medical Research Services and Development Company, Ltd.
    Inventor: Justin Silver
  • Patent number: 6264993
    Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, phosphorous acid or a salt thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: July 24, 2001
    Assignee: Rohm and Haas Company
    Inventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelott
  • Publication number: 20010007864
    Abstract: Method for improving the fruit yields from banana plants, characterized in that an effective and non-phytotoxic dose of a compound A, chosen from:
    Type: Application
    Filed: December 13, 1996
    Publication date: July 12, 2001
    Inventors: JORGE GONZALES, JORGE CEPEDA, JUAN BOCANEGRA
  • Patent number: 6197815
    Abstract: Metal amino acid chelates for animals are beneficial for facilitating and promoting growth by increasing desired metallic ion uptake. The present invention is directed to a process for providing an animal fed additive by preparing metal amino acid chelates, and the metal amino acid chelate growth facilitator, promoter and enhancer prepared by the process.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: March 6, 2001
    Assignee: J.H. Biotech, Inc.
    Inventor: Hsinhung John Hsu
  • Patent number: 6156740
    Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): ##STR1## in which: A is the nitrogen atom or the --CH group,B is the --OCH.sub.2 -- or --CH.sub.2 O-- or CH(CH.sub.3)--O--N.dbd.CH-- or --CH.dbd.N--O--CH(CH.sub.3)-- group or the group ##STR2## R.sub.1 is an alkyl group containing 1 to 4 carbon atoms, R.sub.2 is --OCH.sub.3 or --NHCH.sub.3,X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms,n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups,and at least one fungicidal compound B, anda process for the curative or preventive control of phytopathogenic fungi using the composition.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: December 5, 2000
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Patrice Duvert
  • Patent number: 6123966
    Abstract: A stabilized two-part disinfecting system comprising a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition. The first part contains a non-esterifying acid and an alcohol-containing humectant or antifreeze, while the second part contains a salt of an organic acid and an optional metal chlorite. Methods for making a disinfecting composition by mixing the two-part disinfecting system, as well as for disinfecting substrates by contact therewith, are also disclosed.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: September 26, 2000
    Assignee: Alcide Corporation
    Inventor: Robert D. Kross
  • Patent number: 6113949
    Abstract: This invention relates to a weight control composition, preferably in the form of a capsule or tablet, comprising a mixture of guggul extract and at least one phosphate salt selected from calcium phosphate, potassium phosphate and sodium phosphate. The composition evidences synergistic activity in reducing body weight and percent body fat in mammals. The guggul extract/phosphate salt product also reduces plasma lipid levels and cholesterol in overweight hyperlipidaemic humans. The inventive composition may also contain at least one additional component selected from phosphatidylcholine, hydroxycitric acid and L-tyrosine.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: September 5, 2000
    Assignee: Prolab Nutrition, Inc.
    Inventor: William DesIsles Brink
  • Patent number: 6037366
    Abstract: A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: March 14, 2000
    Assignee: Prohold Medical Technologies, Inc.
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox
  • Patent number: 6024985
    Abstract: The invention provides a synthetic bone precursor material comprising amorphous calcium phosphate and a constituent that inhibits the crystallisation of calcium hydroxyapatite to amorphous calcium phosphate. The synthetic bone precursor may comprise a material of formula CaxMgyPO4 wherein Mg acts as an inhibitor for crystallisation. Other crystallisation inhibitors such as pyrophosphate may be present. The inhibitor is capable of dissolving in physiological saline. Loss of inhibitor from the precursor allows crystallisation of hydroxyapatite. The invention relates to use of a synthetic bone precursor to form bone in vivo, by a transformation of the amorphous precursor material to crystalline hydroxyapatite bone material by the leaching action on inhibitory ions body fluids. it is envisaged that the material will be useful in facilitating bone repair, inducing bone formation or assisting in the attachment of prostheses.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: February 15, 2000
    Assignee: University of Reading
    Inventors: Kenneth Simkiss, Marina Gloria Taylor
  • Patent number: 6015802
    Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): ##STR1## in which: A is the nitrogen atom or the --CH group,B is the --OCH.sub.2 -- or --CH.sub.2 O-- or CH(CH.sub.3)--O--N.dbd.CH-- or --CH.dbd.N--O--CH(CH.sub.3)-- group or the group ##STR2## R.sub.1 is an alkyl group containing 1 to 4 carbon atoms, R.sub.2 is --OCH.sub.3 or --NHCH.sub.3,X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms,n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups,and at least one fungicidal compound B, anda process for the curative or preventive control of phytopathogenic fungi using the composition.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: January 18, 2000
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Patrice Duvert
  • Patent number: 5997910
    Abstract: A fertilizer composition for plants containing phosphonate and phosphate slats, and derivatives thereof is disclosed. The composition provides a single product which may be employed to stimulate the growth response in plants.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: December 7, 1999
    Inventor: John B. Taylor
  • Patent number: 5952010
    Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: September 14, 1999
    Assignee: Norian Corporation
    Inventor: Brent R. Constantz
  • Patent number: 5925383
    Abstract: A fungicidal composition for plants containing phosphonate and phosphate salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a parasitic fungi in plants through mitigation of pathological acerbation of certain fungi.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: July 20, 1999
    Inventor: John B. Taylor
  • Patent number: 5915969
    Abstract: A tooth having a tooth surface with a plurality of tubules and microchannels defined therein is treated with a polymeric hydrogel formed by a polyphosphazene substance and a metal salt. The polyphosphazene substance is first applied to the tooth surface and then the metal salt is applied thereto. The polyphosphazene substance is reacted with the metal salt to form a polymeric hydrogel inside the tubules.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: June 29, 1999
    Inventor: Lars .ANG.ke Linden
  • Patent number: 5906986
    Abstract: A fungicidal composition comprising a compound A having the formula: ##STR1## wherein M is an oxygen or sulphur atom, n is 0 or 1, and Y is a fluorine or chlorine atom or a methyl radical; and at least one fungicidal compound B. A method for preventing or controlling phytopathogenic fungi on crops by applying an effective and non-plant-poisonous amount of said compound on the exposed parts of the plants is also disclosed.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: May 25, 1999
    Assignee: Rhone Poulenc Agrochimie
    Inventor: Marie-Pascale Latorse
  • Patent number: 5900254
    Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: May 4, 1999
    Assignee: Norian Corporation
    Inventor: Brent R. Constantz
  • Patent number: 5863563
    Abstract: Methods and compositions for the treatment of the symptoms of a patient who has a pulmonary condition associated with an inhibition of surfactant secretion by type II alveolar cells are described. The method of treatment involves causing a patient to inhale an amount of a pH-raising buffer effective to raise the pH of the aqueous fluid in the microenvironment of the type II alveolar cell lumenal surface, thereby inducing an increase in the rate of surfactant secretion by type II alveolar cells.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: January 26, 1999
    Assignee: AlphaGene Inc.
    Inventor: George Scheele
  • Patent number: 5800837
    Abstract: A fertilizer composition for plants containing phosphonate and phosphate slats, and derivatives thereof is disclosed. The composition provides a single product which may be employed to stimulate the growth response in plants.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: September 1, 1998
    Assignee: Foliar Nutrients, Inc.
    Inventor: John B. Taylor
  • Patent number: 5801034
    Abstract: This invention provides a method for killing cells in fermentation mixtures in order to prepare the fermentation mixture for processing to recover or extract a desired product from the fermentation mixture. A preferred method of this invention comprises in either order, adjusting the pH of the fermentation mixture to a value equal to or less than about two pH units below the pK.sub.a of the compatible organic acid using a mineral acid, and adding a sufficient amount of a compatible organic acid and/or organic acid salt to the mixture to effect a substantially complete cell kill. The method of this invention is useful for killing microorganisms such as yeast, bacteria or fungi in any culture or fermentation mixture and is particularly useful in systems where it is desired to kill the cells without lysing them.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: September 1, 1998
    Assignee: Genencor International
    Inventors: Virgil B. Lawlis, Jr., Henry G. Heinsohn, Enrique F. Baliu
  • Patent number: 5736164
    Abstract: A fungicidal composition for plants containing phosphonate and phosphate salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control parasitic fungi in plants through mitigation of pathological acerbation of certain fungi.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: April 7, 1998
    Inventor: John B. Taylor
  • Patent number: 5723406
    Abstract: A method for control of horticulture diseases and decontamination of plant tissue which includes applying a solution of hydrogen peroxide to plant tissue, said hydrogen peroxide being a solution having a concentration of between 0.05 to 3.00%. In some cases the hydrogen peroxide solution has a concentration of between 0.05 and 1.5%. Some forms of the invention may utilize a hydrogen peroxide solution that further includes an acid selected from the group consisting of acetic acid and phosphoric acid. Various structures are used for applying the hydrogen peroxide solution such as hydraulic spraying, misting, fogging, or injecting the hydrogen peroxide into a commercial cooling system. In other cases the hydrogen peroxide solution is injected into a recirculating subirrigation nutrient system solution to control microbial growth in the irrigation water. In some cases the hydrogen peroxide solution is applied to the plant tissue at a variety of stages in the plant production cycle.
    Type: Grant
    Filed: January 2, 1996
    Date of Patent: March 3, 1998
    Inventors: Rene N. Larose, Michael N. Abbot
  • Patent number: 5707611
    Abstract: A tooth surface treating agent is provided which comprises a polymerization catalyst and an acidic compound, both water-soluble, the treating agent being capable of enhancing tooth adhesion. The tooth surface treating agent imparts strong adhesion to the enamel and dentin of teeth through simultaneous treatment thereof. The invention is mainly intended for use in the field of dentistry, but is also applicable as a treating agent for vital hard tissues in such fields as surgery, and orthopaedic or plastic surgery.
    Type: Grant
    Filed: December 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Kabushiki Kaisha Shofu
    Inventors: Kunio Ikemura, Yoshiaki Kouro, Hisaaki Tachidokoro, Katsuya Kimoto
  • Patent number: 5698229
    Abstract: An antimicrobial composition, characterized by containing an inorganic compound on which silver ion is supported and a compound represented by the following formula ?2!: ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group and R.sup.2 is hydrogen or an alkali metal.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: December 16, 1997
    Assignee: Toagosei Co., Ltd.
    Inventors: Shuichi Ohsumi, Hideki Kato
  • Patent number: 5656652
    Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham plc
    Inventor: Adrian Francis Davis
  • Patent number: 5653973
    Abstract: Baits useful for controlling lepidoptera populations is made with (a) a diet component for lepidoptera; (b) a toxicant; (c) a chemiluminescent, visual attractant and (d) an encapsulating agent that will allow moisture to permeate and form an external condensate of said diet and said toxicant. The diet, toxicant, and chemiluminescent visual attractant can be used in the same bait particle in a homogeneous or layered structure. Alternatively, the diet/toxicant may be used with a first encapsulating agent in a first bait particle with the chemiluminescent, visual attractant encapsulated in a second bait particle and distributed among the diet/toxicant bait particles.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: August 5, 1997
    Assignee: Micro Flo Company
    Inventors: Chel W. Lew, Keith Branly, Jesse Gaytan, Osborn Jones Turner
  • Patent number: 5629026
    Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist and antacid, optionally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: May 13, 1997
    Assignee: SmithKline Beecham plc
    Inventor: Adrian F. Davis
  • Patent number: 5626883
    Abstract: A vitamin C supplement comprising ascorbic acid, ascorbyl palmitate, niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate, and sodium ascorbate which together can be administered to a human to avoid the transitory initial suppression of human NK cell activity which is present when ascorbic acid alone is administered. Also included is xylitol, lysine acetate, tetrasodium pyrophosphate, ribose, cysteine, and hesperidin which further prolongs the biological activity of ascorbic acid and promotes the uptake of ascorbic acid by human tissue.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: May 6, 1997
    Assignee: Metagenics, Inc.
    Inventor: Stephen M. Paul