Abstract: The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) in low dose ranges in a combination with zinc-L-proline complex and with immunostimulating lipid in doses which synergistically potentiate the effect of each single component whereby the zinc-L-proline complex contains an excess of L-proline or 5-oxo-L-proline which serves as a solubilizer and dispersing agent for the lipid component.

Abstract: Parboiled rice flour is used in lieu of other grain flour in medical foods to minimize antigenicity of the medical food product.

Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.

Abstract: A low odor, aqueous, quick acting room temperature disinfectant solution primarily useful for medical instruments to disinfect within a half hour or less. The composition comprises a reacting or synergistic combination of hydrogen peroxide and from about 1% to 30% by weight of a water soluble organic acid or salt form thereof with the acid preferably being selected from the group consisting of malonic and succinic acids.

Abstract: The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) in low dose ranges in a combination with zinc-L-proline complex and with immunostimulating lipid in doses which synergistically potentiate the effect of each single component whereby the zinc-L-proline complex contains an excess of L-proline or 5-oxo-L-proline which serves as a solubiliser and dispersing agent for the lipid component.

Abstract: A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.

Abstract: A method for minimizing damage to gingival and periodontal tissue is provided through steps that include delivering a first composition containing a zinc salt to a receptacle, delivering a second composition containing a bicarbonate salt to the same receptacle, and transferring within five minutes of delivery to the receptacle the combination into the mouth onto the gingival and periodontal tissues. Where the compositions are semi-solid such as in a toothpaste and/or gel, the receptacle is ordinarily a toothbrush. Liquid compositions such as mouthrinses may employ an expectorant cup as a receptacle.

Abstract: A method for minimizing damage to gingival and periodontal tissue is provided through steps that include delivering a first composition containing a zinc salt to a receptacle, delivering a second composition containing a bicarbonate salt to the same receptacle, and transferring within five minutes of delivery to the receptacle the combination into the mouth onto the gingival and periodontal tissues. Where the compositions are semi-solid such as in a toothpaste and/or gel, the receptacle is ordinarily a toothbrush. Liquid compositions such as mouthrinses may employ an expectorant cup as a receptacle.

Abstract: A storage stable oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt. The presence in the composition of polyvalent metal compounds and fluoride compounds do not affect the stability of the composition as well as reactive ingredients such as peroxide and bicarbonate compounds.

Abstract: This invention relates to an article of manufacture comprising an aqueous gel containing a selected zinc salt contained within a deformable plastic-walled tubular container, for convenient and consistent use as a topical genital lubricant during acts of sexual intercourse. The zinc salt must be organic, water-soluble, and have substantial dissociation rates to release divalent zinc ions. Suitable zinc salts include zinc acetate, zinc propionate, zinc butyrate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, and zinc lactate. The gel must also contain a thickening agent (such as chemically treated cellulose) and a lubricating agent (such as glycerin), and it must be free of heparin, dextran sulfate, or any other anti-coagulant or other component which poses a substantial risk of adverse effects if the lubricant is used frequently and repeatedly over a period of months or years.

Abstract: A method is provided for increasing and maintaining the quantity and activity of immune leukocyte effector cells in preparation for lymphokine and cytokine administration before and during treatment for disease pathogens. The method simultaneously up-regulates the expression of high affinity IL-2 receptors on the above mentioned cells, making them receptive to subsequent IL-2 administration, which activates and directs these cells to mediate cytotoxic activity against disease pathogens. The method may also be employed in conjunction with the administration of other lymphokines, cytokines, biological response modifiers and pharmacological compounds whose activity would benefit from an increase in effector cells. The preferred method of administration is by inhalation of a zinc oxide fume or particulate from 15 to 900 mg ZnO/m.sup.3 for one or more exposures per day, one hour or less per exposure.

Abstract: The present invention is directed to methods and cardioplegic solutions for improving cardiac function and recovery of a mammal after surgical procedures which arrest the heart. In particular the present invention provides methods of improving recovery of a mammal after surgery involving cardiopulmonary bypass when the heart of the mammal is subjected to cardioplegia which include infusing the mammal's heart for a sufficient time at the onset of cardioplegia with a cardioplegic solution which contains an sufficient amount of a zinc-ligand conjugate.

Abstract: An agent which possesses antimicrobial properties and a minimum tendency, or a completely discontinued tendency, to produce contact allergic reactions or toxic effects includes a mixture of a compound which produces Zn.sup.2+ -ions and one or more so-called resin acids or other resin compounds or resin acid derivatives present in the purest possible form, and to the use of the agent in preparing skin, wound, teeth and mucus-membrane treatment products, and to such products as insulating material, building material, paper, surface treatment material, disinfectants, cosmetics and like products which contain conventionally different types of resins.

Abstract: A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.

Abstract: A method for destroying cyst of noxious plankton, which comprises mixing in ballast water hydrogen peroxide or a compound producing the same and maintaining an effective concentration thereof for destroying cyst of noxious plankton.

Abstract: This invention relates to the use of zinc salts as anti-viral agents in sexual lubricants. A zinc salt which releases divalent zinc ions in an aqueous carrier fluid is provided in a sexual lubricant formulation which is spread on the genitals before sexual intercourse. The mixture is non-irritating, and the zinc ions serve as an anti-viral agent to reduce the risk of contracting genital herpes if a sexual partner is infected. These lubricants may also reduce the risk of infection by other sexually transmitted viral diseases, such as hepatitis, papilloma viruses, and AIDS. A preferred lubricant formulation comprises water, a thickening or suspending agent, a lubricating agent, and a suitable zinc salt. Salts which have been tested and shown to be non-irritating during sexual intercourse include zinc acetate, zinc propionate, and zinc gluconate. Other zinc salts have also been identified which are soluble in water and have low pK values, which indicates a high rate of zinc ion release.

Abstract: An aqueous abrasive oral composition which exhibits heightened and rapid whitening of teeth is obtained when using a combination of a dicalcium phosphate compound, a metal ion free peroxide, a chelating agent and a thickening agent.

Abstract: This invention relates to compositions comprising a colloidal or particular metal oxide which are stabilized by low molecular weight carbohydrates. The carbohydrates are characterized by the fact that a) they are not retained on the surface of the metal oxide based on the equilibrium room temperature dialysis of about 2 ml of the metal oxide composition at 0.2 M metal concentration against deionized water; and b) they impart sufficient stability to the metal oxide compositions such that the compositions can withstand heat stress without perceptible aggregation as determined by a prescribed test procedure.

Abstract: Anhydrous oral compositions are disclosed containing an anhydrous humectant and a carboxyvinyl polymer neutralized with an appropriate base.

Abstract: The method comprises forming a sporocide having a defined period of sporocidal activity comprising three components including a peroxide or peroxide generating material, a peroxidase and a salt of iodide which serves as a donor molecule; storing the three components in a nonreacting state to maintain the sporocide in an inactive state and admixing the three components in a aqueous based carrier to cause a catalyzed reaction by said peroxidase for generating free radicals and/or byproducts from the iodide salt (donor molecule) and contacting the surface or object to be sterilized with the activated mixture. The concentration level of the three components can be selected such that an active sporocidal state is maintained for any desired period of time.

Abstract: An ammonium or alkali metal zinc tartrate used in oral compositions such as mouthwashes, gingival and subgingival irrigating solutions, dentifrices, and the like as well as in other preparations for treating oral lesions.