Hydrochloric Acid Patents (Class 424/666)
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Patent number: 11712423Abstract: The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.Type: GrantFiled: April 5, 2021Date of Patent: August 1, 2023Inventors: Nicholas L. Abbott, Christopher J. Murphy
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Patent number: 10039761Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.Type: GrantFiled: April 15, 2016Date of Patent: August 7, 2018Assignee: Vertex Pharmaceuticals IncorporatedInventors: Kwame Wiredu Nti-Addae, Simon Adam O'Neil, Yuegang Zhang, Michael Waldo, Praveen Mudunuri, Bin Song, John Gregg Van Alsten, Mark Strohmeier, Kathy Stavropoulos, Irina Nikolaevna Kadiyala, Mettachit Navamal
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Patent number: 8951577Abstract: A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.Type: GrantFiled: August 3, 2010Date of Patent: February 10, 2015Assignee: Teleflex Medical IncorporatedInventors: Nisha Gupta, Elaine Steinke, Joel Rosenblatt
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Publication number: 20150030702Abstract: A skin dressing is provided comprising a first component including a source of protons, a second component including a nitrite salt, the skin dressing further comprising a non-thiol reductant. The skin dressing is adapted, such that, when the first and second components are brought together and applied to a skin site the nitrite reacts to generate nitric oxide, increasing the pH of the dressing in contact with the skin site from an acidic value to a more neutral value.Type: ApplicationFiled: October 10, 2014Publication date: January 29, 2015Inventors: Jan Jezek, Lynne Patricia Watson
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Patent number: 8883762Abstract: The present invention provides a solution for peritoneal dialysis, consisting of at least two single solutions which are combined after a heat sterilization and are administered to a patient, the first single solution containing an osmotic and the second single solution containing a buffer, and one of these single solutions or another single solution containing electrolyte salts. Glucose-like degradation and hydrolysis is avoided during sterilization and storage, while maintenance of a neutral mixture pH is achieved by the osmotic comprising a glucose polymer and/or glucose polymer derivative, and the pH of the first single solution being between 3.5 and 5.0. The present invention further discloses a twin-chambered pouch consisting of a plastic pouch with at least one first chamber and a second chamber, the first single solution being included in the first chamber and the second single solution being included in the second chamber.Type: GrantFiled: March 3, 2008Date of Patent: November 11, 2014Assignee: Fresenius Medical Care Deutschland GmbHInventor: Thomas Zimmeck
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Patent number: 8853297Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. Alternatively, the kit comprises ready-to-use means for carrying out the method of infiltrating enamel, e.g. application strips with delivery pads soaked with conditioner or infiltrant. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.Type: GrantFiled: May 11, 2007Date of Patent: October 7, 2014Assignees: Charite Universitatsmedizin Berlin, Muhlbauer Technology GmbHInventors: Hendrik Meyer-Lueckel, Sebastian Paris, Jan Mueller, Andrej M. Kielbassa, Bernd Detje
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Publication number: 20140121646Abstract: Methods and devices for preventing nutrient absorption in the small intestine wherein a medical device is passed through the esophagus, and positioned in the small intestine to treat the interior mucosal surface of the small intestine, causing a reduced capacity for nutrient absorption in the treated segment. In one embodiment, the device contains an element that isolates the segment to be treated and allows for the delivery and removal of treatment agents and neutralizing agents.Type: ApplicationFiled: October 29, 2012Publication date: May 1, 2014Inventors: David Lodin, Kemal Schankereli, Howard Lederer
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Patent number: 8709396Abstract: The invention is a method for attracting mosquitoes by producing a volatilized acid by combining an acid precursor with water to produce the humidified vapor acid attractant, preferably hydrogen chloride. The humidified volatilized acid can be further combined with carbon dioxide, or carbon dioxide can be simultaneously produced to attract mosquitoes. The acid precursor can be a hydrate of ferric chloride, such as ferric chloride hexahydrate. The acid precursor can be impregnated in a carrier, and can be combined with water through exposure to water vapor in the atmosphere, the intentional addition of water, or water produced by a chemical reaction.Type: GrantFiled: February 18, 2008Date of Patent: April 29, 2014Assignee: Premark FEG L.L.C.Inventors: Joel Tenney, Tom Isaac, William Ernst
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Publication number: 20130236561Abstract: The instant invention relates to cosmetic compositions with improved dry skin feel characteristics. In particular, the present invention relates to cosmetic formulations comprising certain amidoamines used in combination with fatty acids and selected further acids.Type: ApplicationFiled: March 7, 2012Publication date: September 12, 2013Applicant: EVONIK INDUSTRIES AGInventors: Juergen MEYER, Peter Hameyer, Anna M. HOWE, Maria L. Soldato, Angela Dawn Paez
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Patent number: 8350085Abstract: The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.Type: GrantFiled: June 28, 2011Date of Patent: January 8, 2013Assignee: New Form Pharmaceuticals Inc.Inventor: Scott L. Childs
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Publication number: 20120315341Abstract: A method for treating an inflammation or lesion caused by herpes virus, comprising topically applying to said inflammation or lesion a composition comprising or consisting essentially of a C1 to C3 monohydroxy alcohol or a C2 to C4 diol and a sufficient amount of an acid to adjust the pH of the composition to below 4.6. Topical administration of the composition is preferred and is effective in treating lesions associated infections by viruses such as Herpes simplex. Nasal deliverable forms are effective in treating symptoms due to viruses that cause the common cold. Pharmaceutical compositions for use in the present method are provided.Type: ApplicationFiled: June 11, 2012Publication date: December 13, 2012Applicant: TOPICAL REMEDY LLCInventors: Thomas W. Konowalchuk, Jack Konowalchuk
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Patent number: 8212079Abstract: The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.Type: GrantFiled: September 19, 2008Date of Patent: July 3, 2012Assignee: Aptuit (West Lafayette), LLCInventor: Scott L. Childs
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Publication number: 20120128795Abstract: A method for production of colorless, non-fuming, hazardless and stable aqua-regia solution is provided. The method includes heating a dry mixture of potassium nitrate, potassium chloride and potassium aluminum sulphate to obtain vapors of aqua-regia and condensing the vapors obtained to form a colorless, non-fuming, hazardless and stable aqua-regia solution. The method produces aqua-regia directly from dry salts without adding any single drop of solvent. Aqua-regia obtained by this method is highly stable and possesses dual property of being an anti-diarrheal as well as a rehydrating compound.Type: ApplicationFiled: November 1, 2011Publication date: May 24, 2012Inventor: John VINOTH
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Publication number: 20120093945Abstract: A method for treating an inflammation or lesion caused by herpes virus, comprising topically applying to said inflammation or lesion a composition consisting essentially of a C1 to C3 monohydroxy alcohol or a C2 to C4 diol and a sufficient amount of an acid to adjust the pH of the composition to below 4.6. Topical administration of the composition is preferred and is effective in treating lesions associated infections by viruses such as Herpes simplex. Nasal deliverable forms are effective in treating symptoms due to viruses that cause the common cold. Pharmaceutical compositions for use in the present method are provided.Type: ApplicationFiled: June 15, 2011Publication date: April 19, 2012Applicant: LIFE FORCE TECHNOLOGIES, LLCInventors: Thomas W. Konowalchuk, Jack Konowalchuk
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Publication number: 20120034319Abstract: A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.Type: ApplicationFiled: August 3, 2010Publication date: February 9, 2012Applicant: Teleflex Medical IncorporatedInventors: Nisha Gupta, Elaine Steinke, Joel Rosenblatt
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Publication number: 20110274766Abstract: Disclosed is a method for improving decontamination in meat, poultry, fish, fruit and vegetable processing using a combination of acid(s) and peroxy compound(s). The method comprises a “stacked” approach, sequentially adding the acid(s) and peroxy compound(s) to an aqueous stream to provide a point-of-use low-pH antimicrobial composition that is highly effective for decontamination of food products, as well as safer for use in a processing facility.Type: ApplicationFiled: May 4, 2011Publication date: November 10, 2011Inventors: Randall R. Allen, James Knocke, Carleton J. Parker, III, Jason York, Dean T. Didato
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Patent number: 7976875Abstract: The invention provides a solvating system for the removal of biofilms which solvates the extracellular polysaccharide matrix holding it to a surface. The aqueous solvating system comprises water, a metal ion sequestering agent, and a solvating agent for an extracellular polysaccharide matrix, which is gentle enough to be used directly on human tissues, but which may also be used on hard or soft non-tissue surfaces to breakdown, and/or remove biofilms.Type: GrantFiled: June 23, 2009Date of Patent: July 12, 2011Assignee: Medtronic Xomed, Inc.Inventor: Matthew F. Myntti
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Patent number: 7906152Abstract: Methods and devices for at least reducing the mass of, if not dissolving, renal calculi in situ are provided. In the subject methods, a renal calculus is contacted, e.g. flushed, with an acidic dissolution solution in situ, where the acidic dissolution solution is a solution of a strong, inorganic acid, e.g. hydrochloric acid. In many embodiments, the renal calculus is first enclosed in an isolated local environment of a device prior contact with the dissolution solution. Also provided are novel devices and kits for practicing the subject invention.Type: GrantFiled: December 5, 2005Date of Patent: March 15, 2011Assignee: Cordis CorporationInventor: Brent R. Constantz
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Patent number: 7850996Abstract: The use of selenite- or selenate-containing preparations supplemented with pharmaceutically acceptable or food-compatible acids for the preparation of an agent intended for topical or buccal application or mucosal administration is described.Type: GrantFiled: December 4, 2002Date of Patent: December 14, 2010Assignee: Vis-Vitalis Lizenz-Und Handels AGInventors: Peter Kössler, Norbert Fuchs, Bodo Kuklinski
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Patent number: 7750052Abstract: The present invention relates to the field of food industry, where it may be used for producing alcoholic products, to pharmacology for producing infusions tinctures and extracts or preparations containing aqueous-alcoholic solutions as pharmaceutically acceptable media and also to cosmetology for producing cosmetic products containing aqueous-alcoholic solutions as cosmetically acceptable media. In the proposed process for preparing an aqueous-alcoholic solution, separation of harmful admixtures takes place due to the preliminary protonation separately of water and alcohol prior to the formation of the aqueous-alcoholic solution, this leading to improvements in the physicochemical and organoleptic characteristics of the final product. The process not only provides the possibility of preparing alcoholic beverages of improved quality, but also to shorten the production cycle in the case of preparing some of them (by as much as two times and more) and, as a consequence, to cut down the product costs.Type: GrantFiled: December 23, 2002Date of Patent: July 6, 2010Assignee: OOO “Naucho-Proizvodstvennoe Obiedinenie” “Opytnaya Vodno-Analitcheskaya Laboratoria”Inventor: Valery Nikolaevich Sorokin
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Publication number: 20100143473Abstract: A combination treatment, wherein a strontium-containing compound together with one or more active substances capable of reducing the incidence of bone fracture and/or increasing bone density and/or improving healing of fractured bone and/or improving bone quality are administered for use in the treatment and/or prophylaxis of cartilage and/or bone conditions.Type: ApplicationFiled: May 4, 2009Publication date: June 10, 2010Inventors: Christian Hansen, Henrik Nilsson, Stephan Christgau
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Publication number: 20100092399Abstract: Provided is a method for preventing or treating inflammation and associated states (e.g. infection, hypersensitivity, pain) by administering a therapeutically effective amount of an oxidative reduction potential (ORP) water solution that is stable for at least about twenty-four hours. The ORP water solution administered in accordance with the invention can be combined with one or more suitable carriers and can be administered in conjunction with one or more additional therapeutic agents.Type: ApplicationFiled: December 21, 2009Publication date: April 15, 2010Applicant: Oculus Innovative Sciences, Inc.Inventors: Hojabr Alimi, Andrés Gutiérrez
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Publication number: 20100055204Abstract: Use of hydrochloric acid in the manufacture of a medicament for treating the disease caused by fouling of transport tract, wherein the disease comprises diabetes and prostate disease.Type: ApplicationFiled: September 7, 2007Publication date: March 4, 2010Inventor: Zhiren Liu
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Publication number: 20090304622Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. Alternatively, the kit comprises ready-to-use means for carrying out the method of infiltrating enamel, e.g. application strips with delivery pads soaked with conditioner or infiltrant. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.Type: ApplicationFiled: May 11, 2007Publication date: December 10, 2009Applicants: CHARITE-UNIVERSITATSMEDIZIN BERLIN, ERNST MUHLBAUER GMBH & CO. KGInventors: Hendrik Meyer-Lueckel, Sebastian Paris, Jan Mueller, Andrij M. Kielbassa, Bernd Detje
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Publication number: 20090258086Abstract: The invention provides a solvating system for the removal of biofilms which solvates the extracellular polysaccharide matrix holding it to a surface. The aqueous solvating system comprises water, a metal ion sequestering agent, and a solvating agent for an extracellular polysaccharide matrix, which is gentle enough to be used directly on human tissues, but which may also be used on hard or soft non-tissue surfaces to breakdown, and/or remove biofilms.Type: ApplicationFiled: June 23, 2009Publication date: October 15, 2009Inventor: Matthew F. Myntti
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Publication number: 20090123568Abstract: The pharmaceutical preparation useful for treating a skin or mucous membrane lesion is provided. The pharmaceutical preparation including, as active ingredients, a therapeutically effective amount of trichloroacetic acid and hydrochloric acid, or trichloroacetic acid and formic acid or all three of these acids and optionally a crosslinking/fixating/preserving agent. Additional preparations are also described.Type: ApplicationFiled: January 7, 2009Publication date: May 14, 2009Applicant: INNOVATIVE PHARMACEUTICAL CONCEPTS (IPC) INC.Inventor: Pinchas Burstein
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Publication number: 20090117201Abstract: The invention relates to solutions containing acidic compositions that have a pH of less than 1, are non-caustic to human tissue and are safe for human ingestion. These compositions may be used as the sole or major component of solutions such as cleansers, pharmaceuticals, food preservatives and disinfectants. The acidic compositions may be used in medical, industrial, military and household applications. The invention also relates methods of administering and using the acidic compositions of the invention.Type: ApplicationFiled: December 1, 2008Publication date: May 7, 2009Inventors: Ernest G. Roden, John R. Dankert
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Publication number: 20080317871Abstract: A method of treating hypertension by administering to a patient an aqueous solution of HCl having a pH from 3 to 6.9 for a period of from 0.5 to 6 years and a method of treating a calculus disease by administering an aqueous solution of HCl having a pH from 3 to 6.9 are disclosed.Type: ApplicationFiled: March 6, 2006Publication date: December 25, 2008Inventor: Zhiren Liu
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Patent number: 7452555Abstract: The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.Type: GrantFiled: January 21, 2004Date of Patent: November 18, 2008Assignee: S.S.C.I., Inc.Inventor: Scott L. Childs
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Publication number: 20080206359Abstract: An effective formulation for the treatment and prevention of pseudofolliculitis barbae, commonly called razor bumps, and the skin irritation associated with the condition. The treat formulation can be used as the last step in a multi-step shaving system consisting of a shaving gel, aftershave balm and the aforementioned treat. The treat can also be used as a standalone product and is formulated to treat and prevent shaving symptoms day and night.Type: ApplicationFiled: February 23, 2007Publication date: August 28, 2008Inventor: Nikita Wilson
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Patent number: 7347994Abstract: The invention is a method for attracting mosquitoes by producing a volatilized acid by combining an acid precursor with water to produce the humidified vapor acid attractant, preferably hydrogen chloride. The humidified volatilized acid can be further combined with carbon dioxide, or carbon dioxide can be simultaneously produced to attract mosquitoes. The acid precursor can be a hydrate of ferric chloride, such as ferric chloride hexahydrate. The acid precursor can be impregnated in a carrier, and can be combined with water through exposure to water vapor in the atmosphere, the intentional addition of water, or water produced by a chemical reaction.Type: GrantFiled: September 12, 2003Date of Patent: March 25, 2008Assignee: ICA Trinova, LLCInventors: Joel Tenney, Tom Isaac, William Ernst
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Patent number: 7345029Abstract: The present invention relates to a solution for peritoneal dialysis, consisting of at least two single solutions which are combined after a heat sterilization and are administered to a patient, the first single solution containing an osmotic and the second single solution containing a buffer, and one of these single solutions or another single solution containing electrolyte salts. The avoidance of a glucose-like degradation as well as hydrolysis during sterilization and storage while maintaining a neutral mixture pH is achieved according to the invention by the osmotic comprising a glucose polymer and/or glucose polymer derivative, and the pH of the first single solution being between 3.5 and 5.0. The present invention further relates to a twin-chambered pouch consisting of a plastic pouch with at least one first chamber and a second chamber, the first single solution being included in the first chamber and the second single solution being included in the second chamber.Type: GrantFiled: April 18, 2003Date of Patent: March 18, 2008Assignee: Fresenius Medical Care Deutschland GmbHInventor: Thomas Zimmeck
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Patent number: 7241808Abstract: A composition for the treatment of skin comprises a carboxylated, acidic amino acid obtained by acidifying an acidic amino acid with a carboxylic acid. The resultant material, which is also referred to as a tricarboxylic acid or an amino fruit acid, has significant benefit for the treatment of a number of skin conditions. In addition, the composition of the present invention is very noncaustic to skin, even when employed at a pH as low as 0.5. Also disclosed herein are therapeutic methods and compositions which employ the carboxylated acidic amino acids.Type: GrantFiled: May 1, 2003Date of Patent: July 10, 2007Inventors: Marvin Klein, John E. Kulesza
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Patent number: 7141251Abstract: A composition and therapeutic methods therefore for pharmacologically strong acid solutions comprising a mixture of strong and weak acids.Type: GrantFiled: April 2, 2002Date of Patent: November 28, 2006Assignee: Cytorex Biosciences, inc.Inventor: David Martucci
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Patent number: 6908628Abstract: Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid and halogen salts (Br, I) and/or salts of heavy metals (for example, silver halides) with surfactant agents, either cationic, like chlorhexidine and/or quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, chlorides of ammonium or compounds of ammonium propylamide or anionic, like lauryl sulphate, dodecyl sulphate or alkyl succinic salts, with suitable excipients, some of which may be ethyl or isopropyl alcohol, chlorhexidine, non-chlorinated quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, combined or not with iodine, and/or its salts, together with excipients, some of which may be ethyl or isopropyl alcohol.Type: GrantFiled: June 10, 2002Date of Patent: June 21, 2005Assignee: OFTRAI, S.L.Inventor: Rafael Herruzo Cabrera
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Patent number: 6881424Abstract: A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a strong oxyacid, wherein the resultant acidic composition is less corrosive to a ferrous metal than a solution of a mineral acid having the same acidic pH value as that of the acidic composition, and where in the acid composition is more biocidal than a mixture of the organic acid and a metal salt of the organic acid which mixture has the same acid normality value as that of the acidic composition. The acidic composition can be prepared by mixing at least one regenerating acid, at least one metal base, and at least one organic acid, wherein the amount of the regenerating acid is in excess of the equivalent amount of the metal base.Type: GrantFiled: September 5, 2000Date of Patent: April 19, 2005Assignee: Mionix CorporationInventors: Maurice Clarence Kemp, Robert Blaine Lalum, David E. Lewis, Robert H. Carpenter
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Patent number: 6824794Abstract: A water treatment agent and method of treating water to inhibit, reduce, or prevent the formation of algae and bacteria in a water body. The water treatment agent may include copper sulfate penta-hydrate and/or silver, di-sodium ethylene di-amine tetra-acetic acid dihydrate, a scale inhibitor, a shocking agent and a buffer agent. For instance, the treatment agent may include a composition of copper sulfate pentahydrate, di-sodium ethylene di-amine tetra-acetic acid, monopotassium phosphate or sulfuric acid, and potassium monopersulfate and 1-hydroxyethylidene-1,1-diphosphonic acid.Type: GrantFiled: May 31, 2002Date of Patent: November 30, 2004Assignee: Innovative Water Technologies, Inc.Inventors: Terry A. Ring, Tom Smolkov, M. Anthony Gamarra
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Publication number: 20040234625Abstract: A pharmaceutical preparation useful for treating a skin or mucous membrane lesion is provided. The pharmaceutical preparation including, as active ingredients, a therapeutically effective amount of trichloroacetic acid and hydrochloric acid, or trichloroacetic acid and formic acid or all three of these acids and optionally a crosslinking/fixating/preserving agent. Additional preparations are also described.Type: ApplicationFiled: March 31, 2004Publication date: November 25, 2004Inventor: Pinchas Burstein
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Publication number: 20040067262Abstract: Methods for at least inhibiting the growth of an inorganic structure in an external auditory canal are provided. In practicing the subject methods, the target structure is contacted with an amount of an inorganic matter dissolution solution effective to at least inhibit inorganic structure growth, e.g., by flushing the external auditory canal with an effective amount of an inorganic matter dissolution solution. In addition, the invention provides devices, systems and kits for practicing the subject methods. The subject invention finds use in the treatment of conditions characterized by inorganic growths in the external auditory canal, including diffuse exostosis, tympanic sclerosis, and the like.Type: ApplicationFiled: October 4, 2002Publication date: April 8, 2004Inventor: Brent R. Constantz
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Patent number: 6706290Abstract: Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated with nanobacteria. The present invention also provides methods of treating patients infected with nanobacteria. In particular, the present invention provides a method for preventing the recurrence of kidney stones in a patient that has suffered from kidney stones, comprising administration of an antibiotic, a bisphosphonate, or a calcium chelator, either alone or in combination, in an amount effective to inhibit or prevent the growth and development of nanobacteria.Type: GrantFiled: July 2, 1999Date of Patent: March 16, 2004Inventors: Olvai E. Kajander, Neva Ciftcioglu
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Patent number: 6689393Abstract: A solution, in particular for hemodialysis or peritoneal dialysis that permits attaining a desired glucose concentration without affecting the concentrations of other components in the solution. The solution consists of at least three individual solutions that are combined and administered after heat sterilization. The first solution contains calcium ions, electrolyte salts and optionally glucose in a concentration of 0-1000 mM and is acidified to a pH of less than 4.0 with a physiologically tolerable acid. The second solution contains glucose in a concentration different from that of the first solution and the remaining components of the first solution in the same concentration. The third solution contains a buffer in the physiological range. Also provided is a method of preparing a solution according to the invention, where the desired mixing ratio of the separate solutions is automatically established by a dialysis machine or peritoneal dialysis cycler.Type: GrantFiled: March 22, 2000Date of Patent: February 10, 2004Assignee: Fresenius Medical Care DeutschlandInventor: Thomas Knerr
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Patent number: 6663902Abstract: The present invention relates to a biocidal composition, designed for the generation of chlorine dioxide, comprising at least one iodo-compound having at least one iodine atom and a source of chlorite ions. The molar ration of chlorite ions to iodine atoms is 2 or greater. The composition finds use in a variety of applications including methods of cleaning, sanitizing, deodorizing, and disinfecting various surfaces.Type: GrantFiled: September 19, 2000Date of Patent: December 16, 2003Assignee: Ecolab Inc.Inventors: Robert D. P. Hei, David Daniel McSherry, Kim R. Smith, Keith E. Olson
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Publication number: 20030099716Abstract: Present invention relates to a method and composition for symptomatic relief of vaginitis. Until the treatment of underlying cause takes effect women suffer from unpleasant symptoms of vaginitis restricting daily routine activities. The symptoms of vaginitis may be incapacitating and are a common reason for visiting the gynecologist and can lead to frustration, embarrassment, anger, lost days from work, marital conflict and loss of ability to enjoy a normal personal, professional and social life.Type: ApplicationFiled: November 27, 2002Publication date: May 29, 2003Inventor: Syed Ritzi
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Publication number: 20030087960Abstract: A pharmaceutical preparation useful for treating a skin or mucous membrane lesion is provided. The pharmaceutical preparation including, as active ingredients, a therapeutically effective amount of trichloroacetic acid and hydrochloric acid, or trichloroacetic acid and formic acid or all three of these acids and optionally a crosslinking/fixating/preserving agent. Additional preparations are also described.Type: ApplicationFiled: October 3, 2001Publication date: May 8, 2003Applicant: Innovative Pharmaceutical Concepts (IPC) Inc.Inventor: Pinchas Burstein
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Patent number: 6541421Abstract: This invention relates to a buffered phosphorus containing solution comprising at least one phosphorus compound selected from the group consisting of phosphorous acid, hypophosphorous acid, polyphosphorous acid polyhypophosphorous acid, and salts thereof. The solution also contains a buffer including an organic base in the form of a nitrogen containing compound and its conjugate acid. The solution may be used as a fertilizer or as a fungicide. The invention also relates to a method of preparing such a solution.Type: GrantFiled: October 4, 2000Date of Patent: April 1, 2003Inventors: Alastair James Forsyth, Tomasz Antoni Modro
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Patent number: 6527979Abstract: Catheter systems and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter systems include at least an aspiration catheter and at least one of a total occlusion insert catheter and a partial occlusion insert catheter, where the insert catheters are capable of being slidably moved in the lumen of the aspiration catheter. In practicing the subject methods, a surface of the vascular occlusion is flushed with an acidic dissolution fluid using the subject catheter systems for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter systems and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.Type: GrantFiled: August 27, 1999Date of Patent: March 4, 2003Assignee: Corazon Technologies, Inc.Inventors: Brent R. Constantz, Peter K. Johansson, Erin McGurk
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Patent number: 6524624Abstract: A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid and an optional oxidizable colorant, and wherein the first part, the second part, or both the first and second parts comprise an alpha olefin sulfonate.Type: GrantFiled: May 16, 2001Date of Patent: February 25, 2003Assignee: Alcide CorporationInventors: Joseph Morelli, C. Cayce Warf, Jr., Maura Aldrich, Cecilia Moser Morse, Jean Wiley
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Publication number: 20030035847Abstract: A composition and therapeutic methods therefore for pharmacologically strong acid solutions comprising a mixture of strong and weak acids.Type: ApplicationFiled: April 2, 2002Publication date: February 20, 2003Inventor: David Martucci
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Patent number: 6518247Abstract: In order to lower the painfulness of injection of the remedy containing the products of lignin basic hydrolysis and oxidation, pyrophosphate, NaCl and water the value of pH of the remedy is adjusted to a neutral one by the addition of HCl.Type: GrantFiled: May 15, 2001Date of Patent: February 11, 2003Assignee: Obschestvo s Ogranichennoi Otvetstvennostiju “Ligpharm”Inventors: Dmitriy Victorovich Petukhov, Valeriy Aphanasievich Trophimov, Vladimir Alexandrovich Philov, Valentina Vasilievna Reztsova, Boris Timopheievich Pinchuk
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Publication number: 20020182264Abstract: The invention relates to solutions containing acidic compositions that have a pH of less than 1, are non-caustic to human tissue and are safe for human ingestion. These compositions may be used as the sole or major component of solutions such as cleansers, pharmaceuticals, food preservatives and disinfectants. The acidic compositions may be used in medical, industrial, military and household applications. The invention also relates methods of administering and using the acidic compositions of the invention.Type: ApplicationFiled: April 9, 2002Publication date: December 5, 2002Inventors: Ernest G. Roden, John R. Dankert