Iodate Patents (Class 424/668)
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Patent number: 11653653Abstract: The present invention is directed to a composition in solution (often, an aqueous solution) which comprises a combination of molecular iodine (I2) and an acceptable source of iodate (IO3), and an acid (inorganic or organic), wherein iodide and iodate are present in the composition at a molar ratio of about 0.1 to about 25, the concentration of uncomplexed molecular iodine is a disinfectant, biocidal and/or antimicrobial (depending upon the end use of the composition) effective amount the concentration of acid in the composition is effective to provide a buffering pH in the composition ranging from about 1.5 to about 6.5. Compositions according to the present invention are storage stable for unexpectedly long periods of time (up to about 5 years), and find use as disinfecting solutions, as germicides and/or biocides (e.g. antiviral, antibacterial, antifungal, antispore etc.Type: GrantFiled: November 30, 2021Date of Patent: May 23, 2023Assignee: IOTECH INTERNATIONAL, INC.Inventors: Rodger Elliot Kolsky, Herbert Moskowitz, Jack Kessler
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Patent number: 11297839Abstract: The present invention is directed to a composition in solution (often, an aqueous solution) which comprises a combination of molecular iodine (I2) and an acceptable source of iodate (IO3), and an acid (inorganic or organic), wherein iodide and iodate are present in the composition at a molar ratio of about 0.1 to about 25, the concentration of uncomplexed molecular iodine is a disinfectant, biocidal and/or antimicrobial (depending upon the end use of the composition) effective amount the concentration of acid in the composition is effective to provide a buffering pH in the composition ranging from about 1.5 to about 6.5. Compositions according to the present invention are storage stable for unexpectedly long periods of time (up to about 5 years), and find use as dis infecting solutions, as germicides and/or biocides (e.g. antiviral, antibacterial, antifungal, antispore etc.Type: GrantFiled: August 23, 2018Date of Patent: April 12, 2022Assignee: ioTech International, IncorporatedInventors: Rodger Elliot Kolsky, Herbert Moskowitz, Jack Kessler
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Publication number: 20140322351Abstract: The present invention provides novel compositions comprising: (a) a metaperiodate and (b) chlorhexidine or a chlorohexidine salt and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: ApplicationFiled: May 1, 2014Publication date: October 30, 2014Applicant: Kane Biotech Inc.Inventors: Purushottam GAWANDE, Srinivasa MADHYASTHA, Karen LOVETRI, Nandadeva YAKANDAWALA, Gord FROEHLICH
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Patent number: 8642057Abstract: Antimicrobial solutions and delivery systems for them use liquid antimicrobial solutions with: at least 80% of total weight of a carrier liquid comprising water, alcohol or a mixture of water and alcohol; at least 0.0001% by weight of the solution of I2; at least 0.0001% by weight of CuSO4; and sufficient acid in the solution top provide a pH of less than 7.0. A buffering system is also preferable in the solution, and the solution may be provided directly as a liquid, as a spray, as a gel, imbibed and carried in a wipe, encapsulated solution, segregated droplets of solution (in carrying layers of particles, dispersed in a solid of gel carrier) and the like.Type: GrantFiled: November 30, 2011Date of Patent: February 4, 2014Assignee: Biolargo Life Technologies, Inc.Inventors: Kenneth R. Code, Joseph L. Provenzano, Richard D. Bickerstaff
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Patent number: 8409602Abstract: The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane.Type: GrantFiled: July 29, 2010Date of Patent: April 2, 2013Assignees: Northwestern University, The University of ZurichInventors: Phillip B. Messersmith, Carrie Brubaker, Corinne Zisch
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Publication number: 20130039997Abstract: A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.Type: ApplicationFiled: October 15, 2012Publication date: February 14, 2013Applicant: IOGEN LLCInventor: IOGEN LLC
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Patent number: 8303994Abstract: A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.Type: GrantFiled: June 22, 2006Date of Patent: November 6, 2012Inventors: Jack Howard Kessler, James Carlton Richards
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Publication number: 20110123459Abstract: In accordance with the present invention, iodine, an iodine derivative(s), or a combination of a plurality of these substances is presented as the active ingredient of a stable naturopathic liquid solution. More specifically, in addition to the active ingredient, the naturopathic solution will include a liquid carrier that has been saturated with an inert gas (e.g. Nitrogen) to improve the stability of the active ingredient and increase the shelf life of the solution. For the manufacture of the solution, a liquid carrier (e.g. purified distilled water) is degassed and then subsequently saturated with the inert gas. The active ingredient is then added to the saturated liquid carrier to create the naturopathic liquid solution.Type: ApplicationFiled: November 24, 2009Publication date: May 26, 2011Inventors: William Scott Whiting, John E. Stalcup
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Patent number: 7935366Abstract: A new prophylactic mixture is prepared for the effective decorporation of *Cs, *Sr, *I from affected subjects in the event of an accidental release of the radioisotopes in the environment due to any nuclear accident. The prophylactic mixture comprising: 1) Calcium Potassium Ferrocyanide [CaK2Fe(CN)6] 2) Calcium Iodate, and 3) Calcium Carbonate, can be formulated in the form of a single tablet, capsule or suspension for easy administration to the radiation affected subjects in cases of emergency or nuclear fallout. Also claimed are the compound calcium potassium ferrocyanide (CaK2Fe(CN)6) and the use thereof for decorporation of *Cs in subjects affected by nuclear radiation.Type: GrantFiled: January 10, 2006Date of Patent: May 3, 2011Assignee: Secretary, Department of Atomic EnergyInventors: Dharampal Nandiram Pahuja, Vikram Sarjerao Jagtap, Vinay Ramkrishna Sonawane
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Publication number: 20110027250Abstract: The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane.Type: ApplicationFiled: July 29, 2010Publication date: February 3, 2011Applicant: Northwestern UniversityInventors: Phillip B. Messersmith, Carrie Brubaker, Andreas H. Zisch, Corinne Zisch
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Publication number: 20100310621Abstract: A controlled release molecular iodine biocide for use in human cavities especially the vaginal, penile canal, nasal passages and rectum. Particles can be functionalized with epithelial cell binding molecules and lymphocyte-binding molecules attached to their surfaces. Half of all the particles can contain pH buffer salts that control pH to between around pH 3.5 to pH 4.5. A second half of the particles can contain Iodide and iodate salts. When pH particles and iodate/iodide particles are bound next to each other, molecular iodine is released in a controlled fashion. Molecular iodine is effective biocide. In an alternate embodiment, there can be two distinct populations of particles, one with epithelial cell binding molecules and one with lymphocyte-binding molecules. Again, half of all the particles can contain a pH buffer and half iodide and iodate salts.Type: ApplicationFiled: June 4, 2010Publication date: December 9, 2010Inventor: James C. Richards
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Publication number: 20100247656Abstract: Nano-particles created using a biodegradable chemical backbone structure suitably designed to permit creation of at least two populations of nano-particles that contain chemical compositions. A first population of particles can contain iodide (I?) and additional compounds including a pH buffer and iodate (IO3?). A second population of particles can contain compounds that will create a microenvironment of pH of 5<-<7 immediately surrounding the second population particle as it is resides on the surface of mucous membranes and cells found in the sinuses and upper airways or on any mucous membrane. The two particle populations are maintained in a dry state for delivery into the nasal passages. When they become hydrated, they now gain an affinity to each other as an activation event, and particles from the two populations residing in proximity to each other diffuse their chemical components into the microenvironment. The pH within the microenvironment surrounding the particles becomes <7.Type: ApplicationFiled: March 25, 2010Publication date: September 30, 2010Inventor: James C. Richards
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Patent number: 7153527Abstract: A teat dip composition comprising from about 0.1% to about 2% iodine by weight of the composition on a formulation basis and form about 45% to about 99.9% propylene glycol by weight of the composition on a formulation basis, and a method of using such composition to treat mastitis.Type: GrantFiled: June 7, 2005Date of Patent: December 26, 2006Assignee: WestfaliaSurge, Inc.Inventors: Charles D. Gradle, Alejandro O. Dee
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Patent number: 7014871Abstract: An iodine preparation composition suitable for use on wounds comprising an iodide source, an oxidant and a buffer characterized in that the iodide is held separately from the oxidant until the point of use, and that the buffer is capable of maintaining the pH of the composition at between pH 45 and pH 6 so that iodine is generated at a physiologically acceptable dose rate.Type: GrantFiled: March 13, 2000Date of Patent: March 21, 2006Inventors: Dave Parsons, Elizabeth Jacques, Philip Bowler
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Patent number: 6962714Abstract: The present invention relates to antimicrobial compositions including a critical, near critical, or supercritical (densified) fluid and an antimicrobial agent, to methods of forming these compositions, and to methods employing these compositions. An antimicrobial agent can be generated in the presence of a densified fluid, for example, by reacting an oxidizing agent with a precursor to the antimicrobial agent.Type: GrantFiled: August 6, 2002Date of Patent: November 8, 2005Assignee: Ecolab, Inc.Inventors: Robert D. P. Hei, Keith E. Olson, Robert J. Ryther, Richard K. Staub
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Patent number: 6939569Abstract: There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.Type: GrantFiled: June 18, 1999Date of Patent: September 6, 2005Assignee: Oxibio, Inc.Inventors: Terrence R. Green, Jack Fellman
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Patent number: 6926913Abstract: The invention provides a composition of matter comprising molecular iodine and tetraglycol.Type: GrantFiled: March 22, 2001Date of Patent: August 9, 2005Assignees: Ben Gurion University of the Negev Research & Development Authority, Yissum Research Development Company of the HebrewInventors: Uri Wormser, Amnon Sintov
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Patent number: 6908628Abstract: Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid and halogen salts (Br, I) and/or salts of heavy metals (for example, silver halides) with surfactant agents, either cationic, like chlorhexidine and/or quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, chlorides of ammonium or compounds of ammonium propylamide or anionic, like lauryl sulphate, dodecyl sulphate or alkyl succinic salts, with suitable excipients, some of which may be ethyl or isopropyl alcohol, chlorhexidine, non-chlorinated quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, combined or not with iodine, and/or its salts, together with excipients, some of which may be ethyl or isopropyl alcohol.Type: GrantFiled: June 10, 2002Date of Patent: June 21, 2005Assignee: OFTRAI, S.L.Inventor: Rafael Herruzo Cabrera
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Patent number: 6902747Abstract: A teat dip composition comprising from about 0.1% to about 2% iodine by weight of the composition on a formulation basis and from about 50% to about 99.9% propylene glycol by weight of the composition on a formulation basis, and a method of using such composition to treat mastitis.Type: GrantFiled: May 3, 2000Date of Patent: June 7, 2005Assignee: WestfaliaSurge, Inc.Inventors: Charles D. Gradle, Alejandro O. Dee
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Patent number: 6852340Abstract: A biodegradable composition having long term phase and composition stability, and a method for producing both short and long period biocide activity, is used for disinfecting animal husbandry surfaces, in the medical and food industry, and the like. The composition contains propionic acid for pH control, and preferably iodine or an iodine containing compound. The propionic acid combines with ambient ammonia, or ammonia containing compounds arising from fermenting litter and manure to form ammonium propionate, which in turn inhibits or prevents microorganism formation, including mold formation. A surfactant which complexes with the iodine may also be used for spraying onto surfaces, and is effective in the presence of a high organic challenge and hard water.Type: GrantFiled: March 21, 2000Date of Patent: February 8, 2005Assignee: Preserve InternationalInventors: Gary E. Gaumer, Bruce A. Spielholz
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Patent number: 6814984Abstract: The present invention is directed to frozen biocidal compositions. Specifically, the biocidal compositions comprise a frozen aqueous solution of a plurality of ions selected from the group consisting of halide and oxyhalide ions. The frozen biocidal compositions are useful in preserving or extending the shelf-life of perishable articles.Type: GrantFiled: February 8, 2002Date of Patent: November 9, 2004Assignee: Clean Water International LLCInventors: David C. Rose, Lawrence J. Ventura
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Patent number: 6663902Abstract: The present invention relates to a biocidal composition, designed for the generation of chlorine dioxide, comprising at least one iodo-compound having at least one iodine atom and a source of chlorite ions. The molar ration of chlorite ions to iodine atoms is 2 or greater. The composition finds use in a variety of applications including methods of cleaning, sanitizing, deodorizing, and disinfecting various surfaces.Type: GrantFiled: September 19, 2000Date of Patent: December 16, 2003Assignee: Ecolab Inc.Inventors: Robert D. P. Hei, David Daniel McSherry, Kim R. Smith, Keith E. Olson
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Publication number: 20030175359Abstract: The object of the present invention is to allow an egg originally having almost no active oxygen eliminating ability, to strongly possess an active oxygen eliminating ability. It was found that an egg containing a high level of iodine (4.2 ppm or more) has an ability to eliminate active oxygen, which acts harmfully on the human body.Type: ApplicationFiled: March 12, 2002Publication date: September 18, 2003Inventors: Kunitoshi Sekimoto, Akiko Matsuki, Ayuko Kashimori
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Patent number: 6565891Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.Type: GrantFiled: August 23, 2002Date of Patent: May 20, 2003Assignee: Tsar Health Private Ltd.Inventor: Ranjit Kumar Chandra
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Patent number: 6562378Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.Type: GrantFiled: August 16, 2002Date of Patent: May 13, 2003Assignee: TSAR Health Private Ltd.Inventor: Renjit Kumar Chandra
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Patent number: 6506737Abstract: An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions in an aqueous, non-aqueous, gel, aerosol, solid-phase or powdered media. The oxidizing species can be used to reduce microbial and viral populations on a surface or object or in a body or stream of water. The invention thus finds applications as a bleach, sanitizer, oxidant, or in any other application in which an oxidizing agent can be beneficially used alone or in a formulation.Type: GrantFiled: April 5, 2000Date of Patent: January 14, 2003Assignee: Ecolab, Inc.Inventors: Robert D. P. Hei, Kim Smith
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Publication number: 20020168422Abstract: The present invention relates to two solvent antimicrobial compositions and methods employing these two solvent compositions. The two solvent compositions typically contain a second solvent that is not or is only sparingly soluble in a diluting solvent. The two solvent composition can form a clear single-phase solution. The two solvent antimicrobial compositions can reduce the population of microbes on various surfaces such as facilities, containers, or equipment found in food, beverage, or pharmaceutical industries at temperatures between about −70° C. to about 100° C.Type: ApplicationFiled: February 28, 2002Publication date: November 14, 2002Inventors: Robert D.P. Hei, Brandon Herdt, Lawrence Grab
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Patent number: 6410060Abstract: This invention relates to the method of non-invasively fortifying eggs with iodine as a dietary supplement without compromising the structural integrity of the egg. The eggs are placed in a solution comprising iodide or iodate salts of alkali or alkali earth metals at an effective concentration for a duration of between a few seconds to a few days. Iodine then passes through the egg shell to the interior of the egg until an adequate internal iodine concentration of iodide or iodate salts is produced.Type: GrantFiled: May 19, 1998Date of Patent: June 25, 2002Assignee: Biophile CorporationInventors: Pichit Suvanprakorn, Lerson Tanasugarn, Anusig Limahksohn, Sangsom Sinawat, Prakrom Vuthipongse
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Patent number: 6335374Abstract: A penetrating concentrate containing a biocidal amount of a biocide uses a penetrating carrier vehicle containing an emulsifiable copolymer of a cyclic diene and a polymerizable, unsaturated glyceride. For biocides, such as iodopropargyl carbamate, which otherwise requires use of significant amounts of co-solvent to disperse, is directly soluble in the copolymer thereby eliminating or at least substantially reducing the need for co-solvents to assure stability of the biocide in the formulation. The concentrate also exhibits a low level of volatile organics.Type: GrantFiled: October 7, 1994Date of Patent: January 1, 2002Assignee: Troy Technology Corporation, Inc.Inventors: Eeva-Liisa Kuusisto, Timothy Savage, Peter Schaeufele, Rudi Moerck
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Patent number: 6248335Abstract: A stabilized solid oral pharmaceutical composition comprised of iodide and iodate as the active agents in the presence of one or more pharmaceutical excipients and a method for preparing these stabilized compositions.Type: GrantFiled: February 26, 1999Date of Patent: June 19, 2001Assignee: Symbollon CorporationInventors: Yongjun Duan, Kirk Dinehart, John Hickey, Jack Kessler
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Patent number: 6165485Abstract: A bentonite based organoclay, when mixed with a biocidal quaternary amine containing a benzyl molecule within its structure, acts as a reasonably effective biocide.When this organoclay is further treated with iodine and iodide compounds, its efficiency is greatly enhanced.Type: GrantFiled: July 28, 1998Date of Patent: December 26, 2000Assignee: Biomin, Inc.Inventor: George Alther
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Patent number: 6045787Abstract: Mixtures of iodine source resin with iodine capture resin have been found to provide effective disinfecting of protein containing solutions such as plasma. These mixtures can be used in a chromatographic manner to effectively disinfect solutions while causing minimal damage to labile proteins such as clotting factors. Mixed resins containing equivalent amount of iodine source and iodine capture (50:50) are effective in many cases. If protein damage is still occurring, the ideal mixture may be one containing a lower amount of iodine (e.g. 25:75 or even 5:95). If disinfecting properties prove inadequate, ratios can be increased (e.g. 80:20). Surprisingly, the mixed resins also spare tissue components such as red blood cells and platelets. In some cases mixed resins are even useful in a batch procedure where the resin is removed by centrifugation or filtration at the end of a treatment period.Type: GrantFiled: September 1, 1998Date of Patent: April 4, 2000Assignee: Shanbrom Technologies LLCInventor: Edward Shanbrom
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Patent number: 6034138Abstract: The present invention comprises a concentrated solid or semi-solid disinfectant or sterilant composition for use in an aqueous disinfecting or sterilizing solution, comprising an oxidant and a protected glutaraldehyde such as a glutaraldehyde bisulfite addition compound (GBS): ##STR1## or a glutaraldehyde dioxime compound (GDO): ##STR2## The present invention further provides a method for disinfecting or sterilizing a surface or apparatus comprising the steps of mixing a concentrated solid or semi-solid glutaraldehyde sterilant composition comprising an oxidizing compound and a protected sterilant with water to form a solution and bringing the solution into contact with the surface or apparatus.Type: GrantFiled: November 21, 1995Date of Patent: March 7, 2000Assignee: Block Drug Company, Inc.Inventors: Joseph Synodis, Stuart Wilensky, Alan Halecky
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Patent number: 6008238Abstract: Disclosed is a stable dilute solution composition of a 3-isothiazolone compound selected from the group consisting of 5-chloro-2-methyl-3-isothiazolone, 2-methyl-3-isothiazolone, 5-chloro-2-ethyl-3-isothiazolone, 2-ethyl-3-isothiazolone, 4,5-dichloro-2-methyl-3-isothiazolone, and mixtures thereof in water having extremely low levels of copper ion and an oxidant.Type: GrantFiled: February 13, 1998Date of Patent: December 28, 1999Assignee: Rohm and Haas CompanyInventors: Beverly Jean El A'mma, John Robert Mattox
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Patent number: 5955101Abstract: The present invention is concerned with the use of starch containing amylose as a complexant with iodine for preparing dry powder pharmaceutical formulations useful in the preparation of capsules or tablets. The helical structure of the amylose molecule and its ability to complex. with smaller molecules including iodine make starch (amylose) a desirable vehicle for the administration of iodine (I.sub.2) as a dry powder formulation in capsule or tablet form. These pharmaceutical formulations are particularly useful in the treatment of or the prevention of iodine deficiency diseases including breast dysplasia, breast cancer, endometriosis, premenstrual syndrome and radiation sickness from nuclear fallout.Type: GrantFiled: November 5, 1996Date of Patent: September 21, 1999Assignee: 943038 Ontario Inc.Inventors: William R. Ghent, deceased, Bernard A. Eskin
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Patent number: 5922704Abstract: The present invention provides nutritional supplements for optimal nutrition. Various nutrients are provided in specified ratios to achieve optimal nutrient. For example, omega 3 and omega 6 fatty acids are provided in a ratio of about 2:1. Calcium and magnesium are provided in a ratio of about between 1.3:1 and 1:5:1, and zinc and copper are provided in a ratio of about 5:1. Finally, selenium and iodine are provided in a ratio of about 2:1.Type: GrantFiled: December 24, 1997Date of Patent: July 13, 1999Assignee: Feeling Fine Company LLCInventor: Jeffrey Bland
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Patent number: 5916581Abstract: Stable, aqueous, iodine-based germicidal compositions are provided which include respective amounts of available iodine, non-ionic surfactant (e.g., polyoxyethylene, polyoxypropylene block copolymers) and an iodine-solubilizing halide ion selected from the group consisting of Cl.sup.- and Br.sup.- and mixtures thereof. Use of Cl.sup.- and/or B.sup.- substantially reduces or completely eliminates the need for iodide ion in the compositions for maintaining available iodine in solution. The compositions can be in the form of dilutable concentrates or final use solutions.Type: GrantFiled: October 21, 1997Date of Patent: June 29, 1999Assignee: West Agro, Inc.Inventors: Chris Foret, Thomas C. Hemling
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Patent number: 5910318Abstract: The present invention is concerned with the use of starch containing amylose as a complexant with iodine for preparing dry powder pharmaceutical formulations useful in the preparation of capsules or tablets. The helical structure of the amylose molecule and its ability to complex with smaller molecules including iodine make starch (amylose) a desirable vehicle for the administration of iodine (I.sub.2) as a dry powder formulation in capsule or tablet form. These pharmaceutical formulations are particularly useful in the treatment of or the prevention of iodine deficiency diseases including breast dysplasia, breast cancer, endometriosis, premenstrual syndrome, ovarian cysts and radiation sickness from nuclear fallout.Type: GrantFiled: January 29, 1996Date of Patent: June 8, 1999Assignee: 943038 Ontario Inc.Inventors: William R. Ghent, deceased, Bernard A. Eskin
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Patent number: 5879717Abstract: A wound-healing preparation comprises a solution or paste of a non-reducing sugar and iodine in a vehicle consisting essentially of a pharamcologically acceptable glycol, especially glycerol, and, optionally, water. Preferably, the sugar is sucrose, especially that obtained from sugar beet, and the vehicle is substantially anhydrous glycerol. In one preferred embodiment, the preparation is in the form of a veterinary infusible solution and is particularly useful in the treatment of mastitis. In another embodiment, surgical sutures are treated by coating with the preparation to prevent the presence or abscesses around surgical suture lines.Type: GrantFiled: May 28, 1997Date of Patent: March 9, 1999Assignee: Rita McConn-SternInventors: Rita McConn-Stern, Thomas C. Walsh
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Patent number: 5709851Abstract: A stable pharmaceutical composition with reduced irritancy is provided, the composition comprising an aqueous solution of elemental iodine and at least one organic substance which reacts with iodine, whereby iodine loss is controlled by providing a source of iodate ions in an amount sufficient to provide from 0.01% to 0.04% by weight iodate ions, preferably from 0.02% to 0.03% by weight iodate ions.Type: GrantFiled: May 16, 1994Date of Patent: January 20, 1998Assignee: Euro-Celtique, S.A.Inventors: Ian Richard Buxton, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Allan John Miller, Ronald Brown Miller, Derek Allan Prater
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Patent number: 5643608Abstract: Stable aqueous iodine/iodide/iodate germicidal compositions are provided which have relatively high quantities of free iodine therein and also substantially maintain the starting amounts of available and free iodine throughout a storage period of at least about three months. The compositions of the invention contain from about 0.01-1.4% by weight available iodine, from about 10-125 ppm free iodine, from about 0.005-0.5% by weight iodate ion, from about 0.1-15% by weight of iodine complexing agent, from about 0.004-0.5% by weight iodide ion, and have a pH of from about 2.0-4.5.Type: GrantFiled: March 1, 1996Date of Patent: July 1, 1997Assignee: West Agro, Inc.Inventors: Michael D. McKinzie, Murray W. Winicov
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Patent number: 5629024Abstract: Germicidal iodine based compositions are disclosed that consist of iodide anions, a source of peroxide and peroxidase in combination with iodine sequestering agents. The compositions are formed in situ in an aqueous based medium by combining a peroxide source, iodine ions or source thereof, a peroxidase classified within Enzyme Commission identification No. E.C. 1.11.1.7 and an iodine sequestrant. The addition of a sequestrant before the equilibration of the enzymatic reaction formed by admixing the composition with an aqueous based medium, provides for a non-reactive enzymatic composition. The resulting composition having an increase of available iodine concentration compared to an identical composition without an iodine sequestrant.Type: GrantFiled: August 22, 1994Date of Patent: May 13, 1997Assignee: Symbollon CorporationInventors: Jack H. Kessler, Rick Panicucci, John J. Hickey
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Patent number: 5609866Abstract: Sterilized povidone-iodine (polyvinylpyrrolidone-iodine) in an ointment form is obtained by preparation of a mixture of purified water, povidone-iodine, a non-ionic gelling agent, and a non-ionic low suds surfactant. The ointment is a liquid in the temperature range of about 2.degree. C. to 9.degree. C. because of the influence of the non-ionic gelling agent. At room temperature, the mixture forms a free standing ointment which can be sterilized by gamma radiation without degradation of its antimicrobial efficacy, viscosity or shelf life. The ointment is easily prepared by using chilled purified water which maintains the mixture as a liquid while all of the ingredients are mixed together. At room temperature the mixture becomes a free standing ointment.Type: GrantFiled: December 6, 1993Date of Patent: March 11, 1997Assignee: Becton Dickinson and CompanyInventors: Mohammed A. Khan, John F. Moellmer
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Patent number: 5558881Abstract: Inter alia, an iodophor preparation composition comprising, in addition to a carrier, an iodide source, an oxidant and an acid source, characterised in that at least one of the iodide source, the oxidant and the acid source is only available for reaction with the other components when dissolved in an aqueous medium at the point-of-use is disclosed.Type: GrantFiled: March 24, 1994Date of Patent: September 24, 1996Assignee: Diversey CorporationInventor: Michael P. Corby
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Patent number: 5529770Abstract: Improved, highly viscous film-forming protective germicidal formulations are provided which include water, a germicidal agent (preferably complexed iodine) together with an organic thickener, a skin conditioning agent and a minor amount of polyvinyl pyrrolidone. Preferably, the formulations include iodine complexed with a Poloxamer and PVP, in combination with a xanthan gum and glycerin. The formulations have a viscosity of from about 50-5000 cP and form a flexible residual film when applied to skin. The invention is particularly useful in the preparation of bovine teat dips.Type: GrantFiled: December 9, 1994Date of Patent: June 25, 1996Assignee: West Agro, Inc.Inventors: Michael D. McKinzie, Elizabeth L. Lenahan, Thomas C. Hemling
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Patent number: 5470614Abstract: This invention is a method for the protection of wood and other lignocellulosic materials from attack by micro-organisms with the use of iodates. The method consists of treating wood or other lignocellulosic material by soaking it in a solution of iodate for a period of time ranging from three hours to seven days at temperatures between 20.degree. C. and 50.degree. C. The treated material is then removed from the solution and dried. Wood treated with this method shows resistance to attack by wood-degrading micro-organisms. Furthermore, the iodates are resistant to leaching from the wood and other lignocellulosic materials after such treatment.Type: GrantFiled: April 6, 1995Date of Patent: November 28, 1995Assignee: The United States of America as represented by the Secretary of AgricultureInventors: George C. Chen, Roger M. Rowell
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Patent number: 5409697Abstract: A stable organic iodophor composition including an iodophor wherein the ratio or organic iodine solubilizing compound to iodine is less than 5:1 by weight, and a process for the production of an iodophor composition which process includes dissolving an organic iodine solubilizing compound and iodine or an iodine liberating substance in water in amounts such that the ratio of iodine liberating substance to iodine is less that 5:1 by weight and optionally adjusting the pH. adding an oxidizing agent and readjusting the pH following oxidation.Type: GrantFiled: February 19, 1992Date of Patent: April 25, 1995Assignee: Novapharm Research Pty. Ltd.Inventor: Bruno A. Gluck
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Patent number: 5336416Abstract: A method of controlling the growth of bacteria and algae in utilitarian bodies of water such as industrial cooling towers, swimming pools and hot tubs is described. The method includes adding to the water trivalent copper compounds including the periodate and chelate complexes of biuret an tris-(hydroxymethyl) aminomethane. These compounds meet EPA standards of killing 100% of select coliforms within 10 minutes and are efficacious at concentrations as low as 5-9 PPM.Type: GrantFiled: July 12, 1993Date of Patent: August 9, 1994Assignee: N. Jonas & Co., Inc.Inventor: Marvin S. Antelman
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Patent number: 5310549Abstract: A solid iodine concentrate composition comprising an iodine complex, and a solidifier wherein said iodine complex comprises a complexing agent and an iodine source present in a ratio of at least 1.5:1.Type: GrantFiled: August 31, 1989Date of Patent: May 10, 1994Assignee: Ecolab Inc.Inventor: Sandra L. Bull
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Patent number: RE36605Abstract: This invention relates to a disinfecting epidermal cleaner using peroxidase, peroxide and iodide. The active components are maintained inactive until admixed in a .[.define.]. .Iadd.defined .Iaddend.proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5.Type: GrantFiled: November 4, 1997Date of Patent: March 7, 2000Assignee: Symboollon CorporationInventor: Jack H. Kessler