Iodate Patents (Class 424/668)
  • Patent number: 11653653
    Abstract: The present invention is directed to a composition in solution (often, an aqueous solution) which comprises a combination of molecular iodine (I2) and an acceptable source of iodate (IO3), and an acid (inorganic or organic), wherein iodide and iodate are present in the composition at a molar ratio of about 0.1 to about 25, the concentration of uncomplexed molecular iodine is a disinfectant, biocidal and/or antimicrobial (depending upon the end use of the composition) effective amount the concentration of acid in the composition is effective to provide a buffering pH in the composition ranging from about 1.5 to about 6.5. Compositions according to the present invention are storage stable for unexpectedly long periods of time (up to about 5 years), and find use as disinfecting solutions, as germicides and/or biocides (e.g. antiviral, antibacterial, antifungal, antispore etc.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: May 23, 2023
    Assignee: IOTECH INTERNATIONAL, INC.
    Inventors: Rodger Elliot Kolsky, Herbert Moskowitz, Jack Kessler
  • Patent number: 11297839
    Abstract: The present invention is directed to a composition in solution (often, an aqueous solution) which comprises a combination of molecular iodine (I2) and an acceptable source of iodate (IO3), and an acid (inorganic or organic), wherein iodide and iodate are present in the composition at a molar ratio of about 0.1 to about 25, the concentration of uncomplexed molecular iodine is a disinfectant, biocidal and/or antimicrobial (depending upon the end use of the composition) effective amount the concentration of acid in the composition is effective to provide a buffering pH in the composition ranging from about 1.5 to about 6.5. Compositions according to the present invention are storage stable for unexpectedly long periods of time (up to about 5 years), and find use as dis infecting solutions, as germicides and/or biocides (e.g. antiviral, antibacterial, antifungal, antispore etc.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: April 12, 2022
    Assignee: ioTech International, Incorporated
    Inventors: Rodger Elliot Kolsky, Herbert Moskowitz, Jack Kessler
  • Publication number: 20140322351
    Abstract: The present invention provides novel compositions comprising: (a) a metaperiodate and (b) chlorhexidine or a chlorohexidine salt and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.
    Type: Application
    Filed: May 1, 2014
    Publication date: October 30, 2014
    Applicant: Kane Biotech Inc.
    Inventors: Purushottam GAWANDE, Srinivasa MADHYASTHA, Karen LOVETRI, Nandadeva YAKANDAWALA, Gord FROEHLICH
  • Patent number: 8642057
    Abstract: Antimicrobial solutions and delivery systems for them use liquid antimicrobial solutions with: at least 80% of total weight of a carrier liquid comprising water, alcohol or a mixture of water and alcohol; at least 0.0001% by weight of the solution of I2; at least 0.0001% by weight of CuSO4; and sufficient acid in the solution top provide a pH of less than 7.0. A buffering system is also preferable in the solution, and the solution may be provided directly as a liquid, as a spray, as a gel, imbibed and carried in a wipe, encapsulated solution, segregated droplets of solution (in carrying layers of particles, dispersed in a solid of gel carrier) and the like.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: February 4, 2014
    Assignee: Biolargo Life Technologies, Inc.
    Inventors: Kenneth R. Code, Joseph L. Provenzano, Richard D. Bickerstaff
  • Patent number: 8409602
    Abstract: The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: April 2, 2013
    Assignees: Northwestern University, The University of Zurich
    Inventors: Phillip B. Messersmith, Carrie Brubaker, Corinne Zisch
  • Publication number: 20130039997
    Abstract: A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.
    Type: Application
    Filed: October 15, 2012
    Publication date: February 14, 2013
    Applicant: IOGEN LLC
    Inventor: IOGEN LLC
  • Patent number: 8303994
    Abstract: A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: November 6, 2012
    Inventors: Jack Howard Kessler, James Carlton Richards
  • Publication number: 20110123459
    Abstract: In accordance with the present invention, iodine, an iodine derivative(s), or a combination of a plurality of these substances is presented as the active ingredient of a stable naturopathic liquid solution. More specifically, in addition to the active ingredient, the naturopathic solution will include a liquid carrier that has been saturated with an inert gas (e.g. Nitrogen) to improve the stability of the active ingredient and increase the shelf life of the solution. For the manufacture of the solution, a liquid carrier (e.g. purified distilled water) is degassed and then subsequently saturated with the inert gas. The active ingredient is then added to the saturated liquid carrier to create the naturopathic liquid solution.
    Type: Application
    Filed: November 24, 2009
    Publication date: May 26, 2011
    Inventors: William Scott Whiting, John E. Stalcup
  • Patent number: 7935366
    Abstract: A new prophylactic mixture is prepared for the effective decorporation of *Cs, *Sr, *I from affected subjects in the event of an accidental release of the radioisotopes in the environment due to any nuclear accident. The prophylactic mixture comprising: 1) Calcium Potassium Ferrocyanide [CaK2Fe(CN)6] 2) Calcium Iodate, and 3) Calcium Carbonate, can be formulated in the form of a single tablet, capsule or suspension for easy administration to the radiation affected subjects in cases of emergency or nuclear fallout. Also claimed are the compound calcium potassium ferrocyanide (CaK2Fe(CN)6) and the use thereof for decorporation of *Cs in subjects affected by nuclear radiation.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: May 3, 2011
    Assignee: Secretary, Department of Atomic Energy
    Inventors: Dharampal Nandiram Pahuja, Vikram Sarjerao Jagtap, Vinay Ramkrishna Sonawane
  • Publication number: 20110027250
    Abstract: The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane.
    Type: Application
    Filed: July 29, 2010
    Publication date: February 3, 2011
    Applicant: Northwestern University
    Inventors: Phillip B. Messersmith, Carrie Brubaker, Andreas H. Zisch, Corinne Zisch
  • Publication number: 20100310621
    Abstract: A controlled release molecular iodine biocide for use in human cavities especially the vaginal, penile canal, nasal passages and rectum. Particles can be functionalized with epithelial cell binding molecules and lymphocyte-binding molecules attached to their surfaces. Half of all the particles can contain pH buffer salts that control pH to between around pH 3.5 to pH 4.5. A second half of the particles can contain Iodide and iodate salts. When pH particles and iodate/iodide particles are bound next to each other, molecular iodine is released in a controlled fashion. Molecular iodine is effective biocide. In an alternate embodiment, there can be two distinct populations of particles, one with epithelial cell binding molecules and one with lymphocyte-binding molecules. Again, half of all the particles can contain a pH buffer and half iodide and iodate salts.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 9, 2010
    Inventor: James C. Richards
  • Publication number: 20100247656
    Abstract: Nano-particles created using a biodegradable chemical backbone structure suitably designed to permit creation of at least two populations of nano-particles that contain chemical compositions. A first population of particles can contain iodide (I?) and additional compounds including a pH buffer and iodate (IO3?). A second population of particles can contain compounds that will create a microenvironment of pH of 5<-<7 immediately surrounding the second population particle as it is resides on the surface of mucous membranes and cells found in the sinuses and upper airways or on any mucous membrane. The two particle populations are maintained in a dry state for delivery into the nasal passages. When they become hydrated, they now gain an affinity to each other as an activation event, and particles from the two populations residing in proximity to each other diffuse their chemical components into the microenvironment. The pH within the microenvironment surrounding the particles becomes <7.
    Type: Application
    Filed: March 25, 2010
    Publication date: September 30, 2010
    Inventor: James C. Richards
  • Patent number: 7153527
    Abstract: A teat dip composition comprising from about 0.1% to about 2% iodine by weight of the composition on a formulation basis and form about 45% to about 99.9% propylene glycol by weight of the composition on a formulation basis, and a method of using such composition to treat mastitis.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: December 26, 2006
    Assignee: WestfaliaSurge, Inc.
    Inventors: Charles D. Gradle, Alejandro O. Dee
  • Patent number: 7014871
    Abstract: An iodine preparation composition suitable for use on wounds comprising an iodide source, an oxidant and a buffer characterized in that the iodide is held separately from the oxidant until the point of use, and that the buffer is capable of maintaining the pH of the composition at between pH 45 and pH 6 so that iodine is generated at a physiologically acceptable dose rate.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: March 21, 2006
    Inventors: Dave Parsons, Elizabeth Jacques, Philip Bowler
  • Patent number: 6962714
    Abstract: The present invention relates to antimicrobial compositions including a critical, near critical, or supercritical (densified) fluid and an antimicrobial agent, to methods of forming these compositions, and to methods employing these compositions. An antimicrobial agent can be generated in the presence of a densified fluid, for example, by reacting an oxidizing agent with a precursor to the antimicrobial agent.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: November 8, 2005
    Assignee: Ecolab, Inc.
    Inventors: Robert D. P. Hei, Keith E. Olson, Robert J. Ryther, Richard K. Staub
  • Patent number: 6939569
    Abstract: There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: September 6, 2005
    Assignee: Oxibio, Inc.
    Inventors: Terrence R. Green, Jack Fellman
  • Patent number: 6926913
    Abstract: The invention provides a composition of matter comprising molecular iodine and tetraglycol.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: August 9, 2005
    Assignees: Ben Gurion University of the Negev Research & Development Authority, Yissum Research Development Company of the Hebrew
    Inventors: Uri Wormser, Amnon Sintov
  • Patent number: 6908628
    Abstract: Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid and halogen salts (Br, I) and/or salts of heavy metals (for example, silver halides) with surfactant agents, either cationic, like chlorhexidine and/or quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, chlorides of ammonium or compounds of ammonium propylamide or anionic, like lauryl sulphate, dodecyl sulphate or alkyl succinic salts, with suitable excipients, some of which may be ethyl or isopropyl alcohol, chlorhexidine, non-chlorinated quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, combined or not with iodine, and/or its salts, together with excipients, some of which may be ethyl or isopropyl alcohol.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: June 21, 2005
    Assignee: OFTRAI, S.L.
    Inventor: Rafael Herruzo Cabrera
  • Patent number: 6902747
    Abstract: A teat dip composition comprising from about 0.1% to about 2% iodine by weight of the composition on a formulation basis and from about 50% to about 99.9% propylene glycol by weight of the composition on a formulation basis, and a method of using such composition to treat mastitis.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: June 7, 2005
    Assignee: WestfaliaSurge, Inc.
    Inventors: Charles D. Gradle, Alejandro O. Dee
  • Patent number: 6852340
    Abstract: A biodegradable composition having long term phase and composition stability, and a method for producing both short and long period biocide activity, is used for disinfecting animal husbandry surfaces, in the medical and food industry, and the like. The composition contains propionic acid for pH control, and preferably iodine or an iodine containing compound. The propionic acid combines with ambient ammonia, or ammonia containing compounds arising from fermenting litter and manure to form ammonium propionate, which in turn inhibits or prevents microorganism formation, including mold formation. A surfactant which complexes with the iodine may also be used for spraying onto surfaces, and is effective in the presence of a high organic challenge and hard water.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: February 8, 2005
    Assignee: Preserve International
    Inventors: Gary E. Gaumer, Bruce A. Spielholz
  • Patent number: 6814984
    Abstract: The present invention is directed to frozen biocidal compositions. Specifically, the biocidal compositions comprise a frozen aqueous solution of a plurality of ions selected from the group consisting of halide and oxyhalide ions. The frozen biocidal compositions are useful in preserving or extending the shelf-life of perishable articles.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 9, 2004
    Assignee: Clean Water International LLC
    Inventors: David C. Rose, Lawrence J. Ventura
  • Patent number: 6663902
    Abstract: The present invention relates to a biocidal composition, designed for the generation of chlorine dioxide, comprising at least one iodo-compound having at least one iodine atom and a source of chlorite ions. The molar ration of chlorite ions to iodine atoms is 2 or greater. The composition finds use in a variety of applications including methods of cleaning, sanitizing, deodorizing, and disinfecting various surfaces.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: December 16, 2003
    Assignee: Ecolab Inc.
    Inventors: Robert D. P. Hei, David Daniel McSherry, Kim R. Smith, Keith E. Olson
  • Publication number: 20030175359
    Abstract: The object of the present invention is to allow an egg originally having almost no active oxygen eliminating ability, to strongly possess an active oxygen eliminating ability. It was found that an egg containing a high level of iodine (4.2 ppm or more) has an ability to eliminate active oxygen, which acts harmfully on the human body.
    Type: Application
    Filed: March 12, 2002
    Publication date: September 18, 2003
    Inventors: Kunitoshi Sekimoto, Akiko Matsuki, Ayuko Kashimori
  • Patent number: 6565891
    Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: May 20, 2003
    Assignee: Tsar Health Private Ltd.
    Inventor: Ranjit Kumar Chandra
  • Patent number: 6562378
    Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: May 13, 2003
    Assignee: TSAR Health Private Ltd.
    Inventor: Renjit Kumar Chandra
  • Patent number: 6506737
    Abstract: An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions in an aqueous, non-aqueous, gel, aerosol, solid-phase or powdered media. The oxidizing species can be used to reduce microbial and viral populations on a surface or object or in a body or stream of water. The invention thus finds applications as a bleach, sanitizer, oxidant, or in any other application in which an oxidizing agent can be beneficially used alone or in a formulation.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: January 14, 2003
    Assignee: Ecolab, Inc.
    Inventors: Robert D. P. Hei, Kim Smith
  • Publication number: 20020168422
    Abstract: The present invention relates to two solvent antimicrobial compositions and methods employing these two solvent compositions. The two solvent compositions typically contain a second solvent that is not or is only sparingly soluble in a diluting solvent. The two solvent composition can form a clear single-phase solution. The two solvent antimicrobial compositions can reduce the population of microbes on various surfaces such as facilities, containers, or equipment found in food, beverage, or pharmaceutical industries at temperatures between about −70° C. to about 100° C.
    Type: Application
    Filed: February 28, 2002
    Publication date: November 14, 2002
    Inventors: Robert D.P. Hei, Brandon Herdt, Lawrence Grab
  • Patent number: 6410060
    Abstract: This invention relates to the method of non-invasively fortifying eggs with iodine as a dietary supplement without compromising the structural integrity of the egg. The eggs are placed in a solution comprising iodide or iodate salts of alkali or alkali earth metals at an effective concentration for a duration of between a few seconds to a few days. Iodine then passes through the egg shell to the interior of the egg until an adequate internal iodine concentration of iodide or iodate salts is produced.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: June 25, 2002
    Assignee: Biophile Corporation
    Inventors: Pichit Suvanprakorn, Lerson Tanasugarn, Anusig Limahksohn, Sangsom Sinawat, Prakrom Vuthipongse
  • Patent number: 6335374
    Abstract: A penetrating concentrate containing a biocidal amount of a biocide uses a penetrating carrier vehicle containing an emulsifiable copolymer of a cyclic diene and a polymerizable, unsaturated glyceride. For biocides, such as iodopropargyl carbamate, which otherwise requires use of significant amounts of co-solvent to disperse, is directly soluble in the copolymer thereby eliminating or at least substantially reducing the need for co-solvents to assure stability of the biocide in the formulation. The concentrate also exhibits a low level of volatile organics.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: January 1, 2002
    Assignee: Troy Technology Corporation, Inc.
    Inventors: Eeva-Liisa Kuusisto, Timothy Savage, Peter Schaeufele, Rudi Moerck
  • Patent number: 6248335
    Abstract: A stabilized solid oral pharmaceutical composition comprised of iodide and iodate as the active agents in the presence of one or more pharmaceutical excipients and a method for preparing these stabilized compositions.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: June 19, 2001
    Assignee: Symbollon Corporation
    Inventors: Yongjun Duan, Kirk Dinehart, John Hickey, Jack Kessler
  • Patent number: 6165485
    Abstract: A bentonite based organoclay, when mixed with a biocidal quaternary amine containing a benzyl molecule within its structure, acts as a reasonably effective biocide.When this organoclay is further treated with iodine and iodide compounds, its efficiency is greatly enhanced.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: December 26, 2000
    Assignee: Biomin, Inc.
    Inventor: George Alther
  • Patent number: 6045787
    Abstract: Mixtures of iodine source resin with iodine capture resin have been found to provide effective disinfecting of protein containing solutions such as plasma. These mixtures can be used in a chromatographic manner to effectively disinfect solutions while causing minimal damage to labile proteins such as clotting factors. Mixed resins containing equivalent amount of iodine source and iodine capture (50:50) are effective in many cases. If protein damage is still occurring, the ideal mixture may be one containing a lower amount of iodine (e.g. 25:75 or even 5:95). If disinfecting properties prove inadequate, ratios can be increased (e.g. 80:20). Surprisingly, the mixed resins also spare tissue components such as red blood cells and platelets. In some cases mixed resins are even useful in a batch procedure where the resin is removed by centrifugation or filtration at the end of a treatment period.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: April 4, 2000
    Assignee: Shanbrom Technologies LLC
    Inventor: Edward Shanbrom
  • Patent number: 6034138
    Abstract: The present invention comprises a concentrated solid or semi-solid disinfectant or sterilant composition for use in an aqueous disinfecting or sterilizing solution, comprising an oxidant and a protected glutaraldehyde such as a glutaraldehyde bisulfite addition compound (GBS): ##STR1## or a glutaraldehyde dioxime compound (GDO): ##STR2## The present invention further provides a method for disinfecting or sterilizing a surface or apparatus comprising the steps of mixing a concentrated solid or semi-solid glutaraldehyde sterilant composition comprising an oxidizing compound and a protected sterilant with water to form a solution and bringing the solution into contact with the surface or apparatus.
    Type: Grant
    Filed: November 21, 1995
    Date of Patent: March 7, 2000
    Assignee: Block Drug Company, Inc.
    Inventors: Joseph Synodis, Stuart Wilensky, Alan Halecky
  • Patent number: 6008238
    Abstract: Disclosed is a stable dilute solution composition of a 3-isothiazolone compound selected from the group consisting of 5-chloro-2-methyl-3-isothiazolone, 2-methyl-3-isothiazolone, 5-chloro-2-ethyl-3-isothiazolone, 2-ethyl-3-isothiazolone, 4,5-dichloro-2-methyl-3-isothiazolone, and mixtures thereof in water having extremely low levels of copper ion and an oxidant.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: December 28, 1999
    Assignee: Rohm and Haas Company
    Inventors: Beverly Jean El A'mma, John Robert Mattox
  • Patent number: 5955101
    Abstract: The present invention is concerned with the use of starch containing amylose as a complexant with iodine for preparing dry powder pharmaceutical formulations useful in the preparation of capsules or tablets. The helical structure of the amylose molecule and its ability to complex. with smaller molecules including iodine make starch (amylose) a desirable vehicle for the administration of iodine (I.sub.2) as a dry powder formulation in capsule or tablet form. These pharmaceutical formulations are particularly useful in the treatment of or the prevention of iodine deficiency diseases including breast dysplasia, breast cancer, endometriosis, premenstrual syndrome and radiation sickness from nuclear fallout.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: September 21, 1999
    Assignee: 943038 Ontario Inc.
    Inventors: William R. Ghent, deceased, Bernard A. Eskin
  • Patent number: 5922704
    Abstract: The present invention provides nutritional supplements for optimal nutrition. Various nutrients are provided in specified ratios to achieve optimal nutrient. For example, omega 3 and omega 6 fatty acids are provided in a ratio of about 2:1. Calcium and magnesium are provided in a ratio of about between 1.3:1 and 1:5:1, and zinc and copper are provided in a ratio of about 5:1. Finally, selenium and iodine are provided in a ratio of about 2:1.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: July 13, 1999
    Assignee: Feeling Fine Company LLC
    Inventor: Jeffrey Bland
  • Patent number: 5916581
    Abstract: Stable, aqueous, iodine-based germicidal compositions are provided which include respective amounts of available iodine, non-ionic surfactant (e.g., polyoxyethylene, polyoxypropylene block copolymers) and an iodine-solubilizing halide ion selected from the group consisting of Cl.sup.- and Br.sup.- and mixtures thereof. Use of Cl.sup.- and/or B.sup.- substantially reduces or completely eliminates the need for iodide ion in the compositions for maintaining available iodine in solution. The compositions can be in the form of dilutable concentrates or final use solutions.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: June 29, 1999
    Assignee: West Agro, Inc.
    Inventors: Chris Foret, Thomas C. Hemling
  • Patent number: 5910318
    Abstract: The present invention is concerned with the use of starch containing amylose as a complexant with iodine for preparing dry powder pharmaceutical formulations useful in the preparation of capsules or tablets. The helical structure of the amylose molecule and its ability to complex with smaller molecules including iodine make starch (amylose) a desirable vehicle for the administration of iodine (I.sub.2) as a dry powder formulation in capsule or tablet form. These pharmaceutical formulations are particularly useful in the treatment of or the prevention of iodine deficiency diseases including breast dysplasia, breast cancer, endometriosis, premenstrual syndrome, ovarian cysts and radiation sickness from nuclear fallout.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: June 8, 1999
    Assignee: 943038 Ontario Inc.
    Inventors: William R. Ghent, deceased, Bernard A. Eskin
  • Patent number: 5879717
    Abstract: A wound-healing preparation comprises a solution or paste of a non-reducing sugar and iodine in a vehicle consisting essentially of a pharamcologically acceptable glycol, especially glycerol, and, optionally, water. Preferably, the sugar is sucrose, especially that obtained from sugar beet, and the vehicle is substantially anhydrous glycerol. In one preferred embodiment, the preparation is in the form of a veterinary infusible solution and is particularly useful in the treatment of mastitis. In another embodiment, surgical sutures are treated by coating with the preparation to prevent the presence or abscesses around surgical suture lines.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: March 9, 1999
    Assignee: Rita McConn-Stern
    Inventors: Rita McConn-Stern, Thomas C. Walsh
  • Patent number: 5709851
    Abstract: A stable pharmaceutical composition with reduced irritancy is provided, the composition comprising an aqueous solution of elemental iodine and at least one organic substance which reacts with iodine, whereby iodine loss is controlled by providing a source of iodate ions in an amount sufficient to provide from 0.01% to 0.04% by weight iodate ions, preferably from 0.02% to 0.03% by weight iodate ions.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: January 20, 1998
    Assignee: Euro-Celtique, S.A.
    Inventors: Ian Richard Buxton, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Allan John Miller, Ronald Brown Miller, Derek Allan Prater
  • Patent number: 5643608
    Abstract: Stable aqueous iodine/iodide/iodate germicidal compositions are provided which have relatively high quantities of free iodine therein and also substantially maintain the starting amounts of available and free iodine throughout a storage period of at least about three months. The compositions of the invention contain from about 0.01-1.4% by weight available iodine, from about 10-125 ppm free iodine, from about 0.005-0.5% by weight iodate ion, from about 0.1-15% by weight of iodine complexing agent, from about 0.004-0.5% by weight iodide ion, and have a pH of from about 2.0-4.5.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: July 1, 1997
    Assignee: West Agro, Inc.
    Inventors: Michael D. McKinzie, Murray W. Winicov
  • Patent number: 5629024
    Abstract: Germicidal iodine based compositions are disclosed that consist of iodide anions, a source of peroxide and peroxidase in combination with iodine sequestering agents. The compositions are formed in situ in an aqueous based medium by combining a peroxide source, iodine ions or source thereof, a peroxidase classified within Enzyme Commission identification No. E.C. 1.11.1.7 and an iodine sequestrant. The addition of a sequestrant before the equilibration of the enzymatic reaction formed by admixing the composition with an aqueous based medium, provides for a non-reactive enzymatic composition. The resulting composition having an increase of available iodine concentration compared to an identical composition without an iodine sequestrant.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: May 13, 1997
    Assignee: Symbollon Corporation
    Inventors: Jack H. Kessler, Rick Panicucci, John J. Hickey
  • Patent number: 5609866
    Abstract: Sterilized povidone-iodine (polyvinylpyrrolidone-iodine) in an ointment form is obtained by preparation of a mixture of purified water, povidone-iodine, a non-ionic gelling agent, and a non-ionic low suds surfactant. The ointment is a liquid in the temperature range of about 2.degree. C. to 9.degree. C. because of the influence of the non-ionic gelling agent. At room temperature, the mixture forms a free standing ointment which can be sterilized by gamma radiation without degradation of its antimicrobial efficacy, viscosity or shelf life. The ointment is easily prepared by using chilled purified water which maintains the mixture as a liquid while all of the ingredients are mixed together. At room temperature the mixture becomes a free standing ointment.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: March 11, 1997
    Assignee: Becton Dickinson and Company
    Inventors: Mohammed A. Khan, John F. Moellmer
  • Patent number: 5558881
    Abstract: Inter alia, an iodophor preparation composition comprising, in addition to a carrier, an iodide source, an oxidant and an acid source, characterised in that at least one of the iodide source, the oxidant and the acid source is only available for reaction with the other components when dissolved in an aqueous medium at the point-of-use is disclosed.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: September 24, 1996
    Assignee: Diversey Corporation
    Inventor: Michael P. Corby
  • Patent number: 5529770
    Abstract: Improved, highly viscous film-forming protective germicidal formulations are provided which include water, a germicidal agent (preferably complexed iodine) together with an organic thickener, a skin conditioning agent and a minor amount of polyvinyl pyrrolidone. Preferably, the formulations include iodine complexed with a Poloxamer and PVP, in combination with a xanthan gum and glycerin. The formulations have a viscosity of from about 50-5000 cP and form a flexible residual film when applied to skin. The invention is particularly useful in the preparation of bovine teat dips.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: June 25, 1996
    Assignee: West Agro, Inc.
    Inventors: Michael D. McKinzie, Elizabeth L. Lenahan, Thomas C. Hemling
  • Patent number: 5470614
    Abstract: This invention is a method for the protection of wood and other lignocellulosic materials from attack by micro-organisms with the use of iodates. The method consists of treating wood or other lignocellulosic material by soaking it in a solution of iodate for a period of time ranging from three hours to seven days at temperatures between 20.degree. C. and 50.degree. C. The treated material is then removed from the solution and dried. Wood treated with this method shows resistance to attack by wood-degrading micro-organisms. Furthermore, the iodates are resistant to leaching from the wood and other lignocellulosic materials after such treatment.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: November 28, 1995
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: George C. Chen, Roger M. Rowell
  • Patent number: 5409697
    Abstract: A stable organic iodophor composition including an iodophor wherein the ratio or organic iodine solubilizing compound to iodine is less than 5:1 by weight, and a process for the production of an iodophor composition which process includes dissolving an organic iodine solubilizing compound and iodine or an iodine liberating substance in water in amounts such that the ratio of iodine liberating substance to iodine is less that 5:1 by weight and optionally adjusting the pH. adding an oxidizing agent and readjusting the pH following oxidation.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: April 25, 1995
    Assignee: Novapharm Research Pty. Ltd.
    Inventor: Bruno A. Gluck
  • Patent number: 5336416
    Abstract: A method of controlling the growth of bacteria and algae in utilitarian bodies of water such as industrial cooling towers, swimming pools and hot tubs is described. The method includes adding to the water trivalent copper compounds including the periodate and chelate complexes of biuret an tris-(hydroxymethyl) aminomethane. These compounds meet EPA standards of killing 100% of select coliforms within 10 minutes and are efficacious at concentrations as low as 5-9 PPM.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: August 9, 1994
    Assignee: N. Jonas & Co., Inc.
    Inventor: Marvin S. Antelman
  • Patent number: 5310549
    Abstract: A solid iodine concentrate composition comprising an iodine complex, and a solidifier wherein said iodine complex comprises a complexing agent and an iodine source present in a ratio of at least 1.5:1.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: May 10, 1994
    Assignee: Ecolab Inc.
    Inventor: Sandra L. Bull
  • Patent number: RE36605
    Abstract: This invention relates to a disinfecting epidermal cleaner using peroxidase, peroxide and iodide. The active components are maintained inactive until admixed in a .[.define.]. .Iadd.defined .Iaddend.proportion with water. The pH at which the peroxidase is stored is between 7.0 and 9.0 and the pH of the admixture of the active components is between 3.0 and 6.5.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: March 7, 2000
    Assignee: Symboollon Corporation
    Inventor: Jack H. Kessler