Nitrates Or Nitrites Or Nitric Acid Or Nitrogen Oxides Patents (Class 424/718)
  • Patent number: 11478506
    Abstract: Compositions and methods for improving nitric oxide levels in a subject, comprising administering to a subject, a composition comprising dietary nitrate derived from potassium nitrate, beet root (whole plant, powder, plant extract), and/or nitrate-rich leafy green portions (whole plant, powder, plant extract) that improve functional nitric oxide levels in subjects as shown by increasing salivary bioconversion of nitrate to nitrite, a necessary a required step for nitric oxide mediated health benefits. The disclosed novel compositions improve cardiac health, lowers blood pressure, intraocular pressure, and LDL and restores nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: October 25, 2022
    Assignee: RHA INVESTMENT LIMITED
    Inventor: Shawn J. Green
  • Patent number: 11286414
    Abstract: Combinations of a nitroprusside, such as sodium nitroprusside (SNP; Na2[Fe(CN)5NO].2H2O) and a nitrate, are provided, together with methods for the combined use of the nitroprusside and the nitrate as metabolic inhibitors of microbial cultures. The microbial cultures may include sulfate reducing bacteria (SRB) in aqueous culture. This metabolic inhibition may for example be implemented in the presence of a hydrocarbon, for example in an oil reservoir or in oil field systems and facilities. When applied to an SRB culture in the presence of a hydrocarbon, the combination of the nitroprusside and the nitrate may accordingly be used to ameliorate the biological formation of sulfides, particularly hydrogen sulfide.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: March 29, 2022
    Assignee: UTI Limited Partnership
    Inventors: Tekle Fida, Gerrit Voordouw, Jaspreet Mand
  • Patent number: 11272728
    Abstract: Enteral tube feed for patients in an intensive care unit comprising a lipid component, a carbohydrate component and at least 30 EN % of a protein component based on the total energy content of the enteral tube feed, wherein the protein component comprises a peptide fraction consisting of di-, tri- and oligopeptides with a molecular weight of at most 1 kD, wherein the peptide fraction provides at least 10 EN % of the total energy content of the enteral composition and wherein the carbohydrate component predominantly consists of carbohydrates having a GI of ?35 such as isomaltulose for use in treatment of ICU patients.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 15, 2022
    Assignee: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Edmundo Brito De La Fuente, Susanne Keim, Ericka Pestana
  • Patent number: 11266865
    Abstract: Decontamination compositions useful to decontaminate potentially toxic materials, such as PAH and others, present on clothing comprise an aqueous solution of a water soluble cerium salt or a dispersion of cerium oxide in water. The decontamination composition may optionally include at least one of an oxidizer, a surfactant, a co-solvent, a chelating agent, and a polymer. Methods of decontaminating clothing involve applying the decontamination composition to the clothing.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: March 8, 2022
    Assignee: Battelle Memorial Institute
    Inventors: Ramanathan S. Lalgudi, Richard Harris, Nathan Philip Gano, Erik W. Edwards
  • Patent number: 11219640
    Abstract: Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. The method includes administering to a subject in need of treatment a therapeutically effective amount of inorganic nitrite. The nitrite may be administered by inhalation and may be nebulized. The nitrite may be administered at an emitted dose or in an escalated titrated dose. The nitrite may be a liquid formulation or a dry powder formulation.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: January 11, 2022
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Aires Pharmaceuticals, Inc.
    Inventors: Mark Thomas Gladwin, Hunter Clay Champion, Edwin Parsley
  • Patent number: 10918639
    Abstract: The present invention relates to the combination of stimulators of soluble guanylate cyclase (sGC stimulators) with mineralocorticoid receptor antagonists (MR antagonists) and to the use of the combination for the treatment and/or prophylaxis of cardiac and cardiovascular disorders, of renal and cardiorenal disorders, of pulmonary and cardiopulmonary disorders and also for the treatment and/or prophylaxis of fibrotic disorders.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: February 16, 2021
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Peter Kolkhof, Peter Sandner
  • Patent number: 10864229
    Abstract: Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: December 15, 2020
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
    Inventors: Christopher Kevil, David Lefer, Rakesh Patel
  • Patent number: 10716805
    Abstract: A composition for releasing nitric oxide which provides a rapid release of nitrogen monoxide, and also allows formation of S-nitrosothiol compounds which provide a slower extended release of nitrogen monoxide. A composition kit includes two components that are mixed together to initiate nitric oxide release. The kit includes: a liquid phase comprising a solvent and at least one reducing agent; and a solid phase comprising a nitrate and/or nitrite salt, copper ions and at least one thiol. A method of treating sexual dysfunction involves topically applying the composition to an area of the subject to be treated.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: July 21, 2020
    Assignee: Glanotech Limited
    Inventors: Gioacchino Di Leo, Luciano Caglioti, Alberto Boffi, Luciana Mosca, Robert Giovanni Nisticò
  • Patent number: 10675253
    Abstract: Methods and therapeutics for treating nitric oxide (NO) mediated condition comprising administering a therapeutically effective amount of a pharmaceutical composition containing a therapeutic, wherein the therapeutic one of increases xanthine oxidase (XO) associated nitrite conversion to nitric oxide and increases nitrite conversion to nitric oxide via DADS. Method and devices for measuring an amount of nitrite in a sample comprising obtaining a sample, adding diallyl disulfide (DADS) to the sample, measuring a post DADS amount of nitric oxide (NO) in the sample, and using the post DADS amount of NO in the sample to determine the amount of nitrite in the sample.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: June 9, 2020
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
    Inventors: Christopher Kevil, Sibile Pardue
  • Patent number: 10624921
    Abstract: Compositions and methods for improving nitric oxide levels in a subject, comprising administering to a subject, a composition comprising dietary nitrate derived from potassium nitrate, beet root (whole plant, powder, plant extract), and/or nitrate-rich leafy green portions (whole plant, powder, plant extract) that improve functional nitric oxide levels in subjects as shown by increasing salivary bioconversion of nitrate to nitrite, a necessary a required step for nitric oxide mediated health benefits. The disclosed novel compositions improve cardiac health, lowers blood pressure, intraocular pressure, and LDL and restores nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: April 21, 2020
    Assignee: Berkeley Nox Limited
    Inventor: Shawn J. Green
  • Patent number: 10613103
    Abstract: Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD). Methods for treating premature infants identified as at risk and/or likely to benefit are provided. also provided are methods for identifying premature infants that are not at risk for developing bronchopulmonary dysplasia and/or unlikely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia, and methods for avoiding risks of toxicity and undesirable side effects associated with inhaled nitric oxide therapy comprising administering only non-iNO treatment modalities to these infants.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: April 7, 2020
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Douglas Stuart Greene, Joseph J. Medicis, Jim Potenziano
  • Patent number: 10596188
    Abstract: A method of treating neuropathy in a subject, the method comprising identifying a subject who has neuropathy; and administering to the subject a pharmaceutical composition comprising one of inorganic nitrite and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: March 24, 2020
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Christopher Kevil
  • Patent number: 10583309
    Abstract: A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: March 10, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl A. Deisseroth, Scott L. Delp, Michael E. Llewellyn, Christine A. McLeavey Payne
  • Patent number: 10537697
    Abstract: A method and system for generating and delivering nitric oxide directly to a patient. A reaction chamber is provided that is located at or in close proximity to the patient and reactants within the reaction chamber react together to produce a predetermined amount of nitric oxide. The reaction is controlled by metering at least one of the reactants into the reaction chamber to generate a predetermined quantity of nitric oxide as required by the patient. The reactants can include a nitrite salt, such as sodium nitrite, and a reductant such as ascorbic acid, maleic acid or a mixture thereof. By generating and delivering the nitric oxide directly to the patient in close proximity thereto, the formation of NO2 is minimized. One or both of the reactants may be in liquid form.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: January 21, 2020
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: Frederick Montgomery, Duncan Bathe
  • Patent number: 10517817
    Abstract: A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: December 31, 2019
    Assignee: SYK TECHNOLOGIES, LLC
    Inventors: Christian S. Minton, Stephen D. Minton, J. W. Randolph Miller
  • Patent number: 10471109
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: November 12, 2019
    Assignee: The Board of Regents of The University of Texas System
    Inventor: Nathan S. Bryan
  • Patent number: 10420838
    Abstract: Disclosed are methods for treating one or more mammalian cancers, and in particular, methods for treating human melanoma, or a head or neck cancer, that employ therapeutically-effective amounts of one or more iNOS pathway-inhibitory compounds, either alone, or in combination with one or more selected antihypertensive agents (including, for example, calcium channel antagonists), alone, or further in combination with one or more conventional chemotherapeutic agents. Also disclosed are pharmaceutical formulations that comprise these compositions, as well as methods for their use in treating refractory, metastatic, and/or relapsed cancers, or, for use in the management or reversal of treatment resistance in one or more such mammalian cancers.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: September 24, 2019
    Assignee: The Methodist Hospital
    Inventor: Jenny Chee Ning Chang
  • Patent number: 10398820
    Abstract: Described are systems and methods for administration of nitric oxide (NO) with use of left ventricular assists devices (LVADs), as well as systems and methods for monitoring the NO delivery devices and/or the LVAD.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: September 3, 2019
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: Jim Potenziano, Douglas Alan Greene, Craig Flanagan
  • Patent number: 10391102
    Abstract: Pharmaceutical compositions and methods for inducing conscious sedation using such compositions are described, the compositions comprising a benzodiazepine-based compound, a NMDA antagonist, and optionally a ?-blocker, antiemetic, an NSAID, and/or an antihistamine medication. Methods for fabricating the compositions and using them for anesthesiological applications are also described.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: August 27, 2019
    Assignee: Melt Pharmaceuticals, Inc.
    Inventors: John Berdahl, William F. Wiley, Dennis Elias Saadeh
  • Patent number: 10392384
    Abstract: The present invention relates to a novel process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and recovering (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) proceeding from (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula ent-(I)
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: August 27, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Johannes Platzek, Kathrin Gottfried, Jens Assmann, Giulio Lolli
  • Patent number: 10335567
    Abstract: The present invention provides a system and method for delivery of nitric oxide to the upper respiratory tract without resulting in nitric oxide delivery to the lungs. In certain embodiments, the invention comprises the use of a flow sensor to sense the exhalation of the subject, and delivering a nitric oxide containing gas upon sensed exhalation.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: July 2, 2019
    Assignee: 12th Man Technologies, Inc.
    Inventors: Alex Stenzler, Steve Han
  • Patent number: 10272039
    Abstract: A sodium nitrite formulation for topical administration is described. The formulation includes an aqueous solution of non-acidified sodium nitrite dispersed in a white petrolatum ointment. The concentration of sodium nitrite in the formulation is about 0.5% to about 3.0% by weight. To prepare the formulation, non-acidified sodium nitrite is completely dissolved in a small quantity of water, sterile filtered and dispersed in white petrolatum ointment.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: April 30, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Haksong Jin, George Grimes, Deborah Sperling, Gopal Potti, Caterina P. Minniti, Gregory J. Kato
  • Patent number: 10172362
    Abstract: Biofilms are provided which are capable of regulating their own thickness, reducing contamination and preventing biofouling. Constructs are introduced into bacteria that comprise nucleic acid molecules encoding an autoinducer synthase polypeptide, a transcriptional regulator and a biofilm dispersal protein. Nucleic acid molecules may also be introduced which encode a nitric oxide synthase, an epoxide hydrolase, or both. Biofilms of the bacteria may be used to reduce biofouling and contamination of a surface.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: January 8, 2019
    Assignee: The Penn State Research Foundation
    Inventors: Thomas K. Wood, Manish Kumar, Thammajun L. Wood
  • Patent number: 9968292
    Abstract: Disclosed are devices, methods and surgical procedures for detecting, imaging, analyzing, diagnosing and/or treating vascular disorders and related conditions of the human and mammalian body in males and/or females. In particular embodiments, treatments include methods for imaging, analyzing and improving erectile dysfunction and related conditions and potentially increasing angiogenesis in response to specifically diagnosed conditions.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: May 15, 2018
    Assignee: CARDIOVASCULAR BIOTHERAPEUTICS, INC.
    Inventors: Vance Gardner, John Jacobs, Laurence R Meyerson, Mickael Flaa
  • Patent number: 9855211
    Abstract: The present invention relates generally to topical compositions and methods of using the same.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: January 2, 2018
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Adam Sabouni, Eleftherios Kougoulos, Nathan Stasko
  • Patent number: 9759716
    Abstract: A single device to collect, transfer, and measure salivary nitric oxide analyte and metabolite, nitrite, a biomarker for nitric oxide, as well as, a method to assess the effects of diet and exercise on changing an individual's nitric oxide status and health.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: September 12, 2017
    Assignee: Berkeley NOX Limited
    Inventors: Natalie Green, Juliana Green
  • Patent number: 9750787
    Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, including treatment and prevention of learning and memory disorders, and enhancement of learning or memory. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide and/or peptide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: September 5, 2017
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9737562
    Abstract: The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 22, 2017
    Assignee: THE MCLEAN HOSPITAL CORPORATION
    Inventors: Edward G. Meloni, Marc J. Kaufman
  • Patent number: 9724419
    Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, and treatment of metabolic conditions. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: August 8, 2017
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9649334
    Abstract: Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: May 16, 2017
    Assignees: The UAB Research Foundation, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher Kevil, David Lefer, Rakesh Patel
  • Patent number: 9597400
    Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, and treatment of metabolic conditions. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: March 21, 2017
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9561249
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for modulating brain function, in particular improving mood and/or psychological state, in the treatment of disorders of brain development, and in the treatment and/or reduction of pain.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: February 7, 2017
    Assignee: TheraVasc Inc.
    Inventors: Christopher Kevil, Kyle Chan, Amol Soin
  • Patent number: 9545422
    Abstract: The present disclosure provides neuromodulators, nucleic acid encoding thereof, and compositions thereof for endowing visual processing abilities to neuronal cells. The present disclosure further provides a method of restoring light sensitivity to degenerate retinas.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: January 17, 2017
    Assignee: The Regents of the University of California
    Inventors: Kenneth P. Greenberg, Frank Werblin
  • Patent number: 9427605
    Abstract: A cosmetic treatment device includes a nitric oxide (NO) eluting polymer, a carrier, and a proton donor enclosed in a container that keeps the proton donor separate from the nitric oxide eluting polymer until the device is used. When the container is opened, proton donor contacts the polymer, causing the elution of nitric oxide from the polymer.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: August 30, 2016
    Assignee: Novan, Inc.
    Inventor: Tor Peters
  • Patent number: 9360490
    Abstract: A single device to collect, transfer, and measure salivary nitric oxide analyte and metabolite, nitrite, a biomarker for nitric oxide, as well as, a method to assess the effects of diet and exercise on changing an individual's nitric oxide status and health.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 7, 2016
    Assignee: Berkeley Test, LLC
    Inventors: Natalie Green, Juliana Green
  • Patent number: 9320758
    Abstract: The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth, muscle repair, improved muscular and neuromuscular control, and treatments for neuromuscular and neurological disorders, including brain disorders. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptides may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide and/or peptide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location where muscle growth, muscle repair, or improved muscular and neuromuscular control is desired, or on another suitable portion of the skin.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: April 26, 2016
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9314422
    Abstract: The present invention generally relates to compositions and methods for topical or transdermal delivery, and treatment of metabolic conditions. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: April 19, 2016
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9295681
    Abstract: A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an ?-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The ?-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: March 29, 2016
    Assignee: Kantian Sciences Corporation
    Inventor: Robert D. Kross
  • Patent number: 9199026
    Abstract: Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: December 1, 2015
    Assignee: SOMERSET GROUP ENTERPRISES, INC.
    Inventors: David G. Greenberg, Scott Puritz, Tatiana Koutchma, Juan N. Walterspiel
  • Patent number: 9089698
    Abstract: An apparatus for in vivo electroporating a plasmid into a retina of any eye includes a first electrode with a first polarity of voltage placed in contact with a cornea of the eye, a second electrode with an opposite second voltage at least in part behind the retina, and a pulsed voltage source for providing a pulsed DC voltage with an optimized field strength amplitude, frequency, number of pulses, group repetition rate and duration of pulse and group repetition, which are optimized for transfection of the channelrhodospsin-2 (ChR2) gene into the retinal ganglion cells. An in vivo method for treating retinal ganglion cells in an eye without use of viral transfection includes the steps of nonviral in vivo delivering a channelrhodospsin-2 (ChR2) gene to target the specific (retinal ganglion) cells of a retina by intravitreous injection of plasmid DNA, electroporating the plasmid into the retina and use of image intensification device for stimulating the retinal ganglion cells with ambient lighting conditions.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: July 28, 2015
    Assignee: The Regents of the University of California
    Inventors: Samarenda K. Mohanty, Matthew Ficinski, Edward K. Wong, Michael W. Berns
  • Publication number: 20150140131
    Abstract: The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.
    Type: Application
    Filed: December 18, 2014
    Publication date: May 21, 2015
    Inventors: Robert Allaker, Charles Hinds, Arthur Tudor Tucker
  • Patent number: 9034355
    Abstract: A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: May 19, 2015
    Assignee: Colorado State University Research Foundation
    Inventors: Melissa M. Reynolds, Vinod B. Damodaran
  • Publication number: 20150132345
    Abstract: Topical formulations, comprising a carrier having gaseous nitric oxide sequestered therein, and optionally further comprising a pharmaceutically, cosmetic or cosmeceutically active agent, which are useful is medical, cosmetic or cosmeceutic applications, are provided herein. Systems, devices and processes for obtaining such formulations are also disclosed.
    Type: Application
    Filed: May 9, 2012
    Publication date: May 14, 2015
    Inventors: Yossef Av-Gay, Horacio Bach
  • Publication number: 20150125553
    Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
    Type: Application
    Filed: January 5, 2015
    Publication date: May 7, 2015
    Applicants: The Government of the United States of America as represented by the Secretary of the Department of, The Board of Supervisors of Louisiana State Univer and Agricultural and Mechanical College, Acting t, The UAB Research Foundation, Loma Linda University, Wake Forest University
    Inventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III
  • Publication number: 20150125552
    Abstract: The invention concerns a gaseous medicine comprising a mixture of nitrogen monoxide (NO) and nitrogen (N2) for use by inhalation for the treatment of hypoxemic respiratory failure linked to pulmonary vasoconstriction in humans, said gaseous mixture containing between 1200 and 4500 ppm by volume (ppmv) of nitrogen monoxide (NO) and said hypoxemic respiratory failure being chosen from acute respiratory distress syndrome (ARDS) or persistent pulmonary hypertension of the newborn infant (PPHN).
    Type: Application
    Filed: April 15, 2013
    Publication date: May 7, 2015
    Inventors: Pierre De Villemeur, Laurent Lecourt
  • Publication number: 20150118268
    Abstract: A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
    Type: Application
    Filed: January 15, 2015
    Publication date: April 30, 2015
    Inventors: Melissa M. Reynolds, Benjamin P. Reynolds
  • Publication number: 20150110899
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia, in particular peripheral artery disease (PAD).
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventors: Christopher KEVIL, Anthony GIORDANO
  • Patent number: 9011935
    Abstract: The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: April 21, 2015
    Assignees: Barts Health National Health Service Trust, Queen Mary and Westfield College
    Inventors: Robert Allaker, Charles Hinds, Arthur Tudor Tucker
  • Publication number: 20150104518
    Abstract: Methods and compositions are disclosed that enhance delivery of nitric oxide (NO) by combining nitric oxide releasing nanoparticles (NO-np) with exogenous glutathione (GSH), as well as therapeutic uses of the methods and compositions.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 16, 2015
    Inventors: Adam Friedman, Joel Friedman, Joshua Nosanchuk, Parimala Nacharaju, Karin Blecher, Chaim Tuckman-Vernon
  • Publication number: 20150086651
    Abstract: The present disclosure relates to a skin dressing adapted, on activation, to generate one or more S-nitrosothiols by reaction between a thiol and a nitrite salt in the skin dressing for delivery of nitric oxide to a body site. The skin dressing comprises a source of Cu2+, Zn2+ and/or Fe2+ ions.
    Type: Application
    Filed: October 10, 2014
    Publication date: March 26, 2015
    Inventors: Jan Jezek, Lynne Patricia Watson