Nitrates Or Nitrites Or Nitric Acid Or Nitrogen Oxides Patents (Class 424/718)
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Publication number: 20100173019Abstract: A method for stabilizing collagenous eye tissues by nitrite and nitroalcohol treatment. The topical stiffening agent contains sodium nitrite or a nitroalcohol in a buffered balanced salt solution and can be applied to the surface of the eye on a daily basis for a prolonged period. Application of the solution results in progressive stabilization of the corneal and scleral tissues through non-enzymatic cross-linking of collagen fibers. The compounds can penetrate into the corneal stroma without the need to remove the corneal epithelium. In addition, ultraviolet light is not needed to activate the cross-linking process. The resulting stabilization of corneal and scleral tissues can prevent future alterations in corneal curvature and has utility in diseases such as keratoconus, keratectasia, progressive myopia, and glaucoma.Type: ApplicationFiled: December 6, 2007Publication date: July 8, 2010Inventors: David Choohyun Paik, Stephen Lewis Trokel
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Patent number: 7744928Abstract: Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.Type: GrantFiled: April 14, 2006Date of Patent: June 29, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Florian Niklas Ludwig, Stephen Pacetti, Paul Consigny
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Publication number: 20100158981Abstract: Disclosed herein are implantable medical devices comprising controlled release biodegradable block copolymers or coated with controlled release block copolymers and at least one drug releasable from the block copolymer. The controlled release block copolymers comprise least two blocks selected from the group consisting of polyesters, polyethers, and polyurethanes.Type: ApplicationFiled: February 19, 2010Publication date: June 24, 2010Applicant: Medtronic Vascular, Inc.Inventors: Ya Guo, Peiwen Cheng
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Publication number: 20100158813Abstract: A method of making PVA microbubbles including a functionalisation step in which PVA polymeric chains are functionalised at their ends with aldehyde groups, and a subsequent cross-linking step, in which in an air-aqueous solution emulsion with a pH between 4.5 and 5.5 the previously functionalised PVA polymeric chains cross-link by means of an acetalisation reaction, thereby forming the microbubbles. The microbubbles produced are subsequently subjected to a lyophilising step, a filling step in which medicinal gas is introduced and a restoration step of the microbubbles by adding an aqueous solution.Type: ApplicationFiled: August 3, 2007Publication date: June 24, 2010Inventors: Gaio Paradossi, Francesca Cavalieri
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Publication number: 20100150898Abstract: Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The compound may be administered as a liquid or dry powder aerosol formulation. Diseases that can be treated by the method include cystic fibrosis, chronic bronchitis, and ciliary dyskinesia. The formulations of the invention can also be used in conjunction with other active agents such as bronchodilators, sodium channel blockers, antibiotics, enzymes, or purinoceptor agonists on airway surfaces.Type: ApplicationFiled: February 22, 2010Publication date: June 17, 2010Inventor: Richard C. Boucher, Jr.
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Publication number: 20100150991Abstract: A device for providing improved wound healing is described. The device includes a vacuum system for applying a sub-atmospheric pressure to the wound, a gas supply system for applying a gaseous wound healing agent to the wound, and a controller connected with the vacuum system and the gas supply system that controls the applications of the sub-atmospheric pressure and the application of the gaseous wound healing agent to the wound. A method of using the device for improved wound healing is also described.Type: ApplicationFiled: November 19, 2009Publication date: June 17, 2010Inventor: Brent H. BERNSTEIN
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Publication number: 20100143473Abstract: A combination treatment, wherein a strontium-containing compound together with one or more active substances capable of reducing the incidence of bone fracture and/or increasing bone density and/or improving healing of fractured bone and/or improving bone quality are administered for use in the treatment and/or prophylaxis of cartilage and/or bone conditions.Type: ApplicationFiled: May 4, 2009Publication date: June 10, 2010Inventors: Christian Hansen, Henrik Nilsson, Stephan Christgau
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Publication number: 20100143503Abstract: The present invention provides methods of reducing the cytotoxic effects of nitric oxide and sulfides comprising coadministering nitric oxide with sulfide. In addition, the present invention provides novel pharmaceutical compositions comprising both nitric oxide and sulfide. The methods and compositions of the present invention may be used in the treatment or prevention of a variety of diseases and disorders, and also in the prevention of cell or tissue damage, including that resulting from ischemi hypoxia.Type: ApplicationFiled: December 20, 2007Publication date: June 10, 2010Applicant: Ikaria, Inc.Inventors: Csaba Szabo, Kevin James Tomaselli
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Publication number: 20100143504Abstract: In various aspects the present inventions provide compositions and methods for treatment of cardiac conditions. In various embodiments, the present inventions provide methods for treating a cardiac condition comprising the step of administering in a therapeutically effective amount the substantially cell free solution of an amphiphilic self-assembling peptide to a site of cardiac tissue that has been injured due to one or more of atrial fibrillation, acute myocardial infarction; valve disease, pericardial disease, congenital heart disease, congestive heart failure, and embolism.Type: ApplicationFiled: December 11, 2007Publication date: June 10, 2010Applicant: 3D MATRIXInventors: Lisa Spirio, Zen Chu
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Publication number: 20100143505Abstract: The present invention relates to new indanone inhibitors of acetylcholinesterase, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: December 9, 2009Publication date: June 10, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Sepehr Sarshar, Manouchehr M. Shahbaz
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Publication number: 20100136142Abstract: The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.Type: ApplicationFiled: February 19, 2008Publication date: June 3, 2010Applicant: BAYER SCHERING PAHARMA AKTIENGESELLSCHAFTInventors: Lars Bärfacker, Peter Kolkhof, Karl-Heinz Schlemmer, Rolf Grosser, Adam Nitsche, Martina Klein, Klaus Münter, Barbara Albrecht-Küpper, Elke Hartmann
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Publication number: 20100129474Abstract: A method for the control of microorganisms, fungi or oomycetes in agriculture, said method comprising applying to plants or to the environment thereof, an anti-microbial, anti-fungal or anti-oomycetes effective amount of a combination of: (i) an agriculturally acceptable acidifying agent, and (ii) an agriculturally acceptable source of nitrite ions or a nitrate precursor thereof, wherein the combination of (i) and (ii) acts as a source of nitric oxide. Systems and compositions for use in this method are also described and claimed.Type: ApplicationFiled: September 24, 2007Publication date: May 27, 2010Applicant: UNIVERSITY OF EXETERInventors: Nigel Benjamin, Nicholas Jose Talbot, Michael John Kershaw, Paul Graham Winyard
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Publication number: 20100111845Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: October 31, 2008Publication date: May 6, 2010Inventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
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Publication number: 20100112033Abstract: This invention relates to stents coated with hydrophilic polymers containing S-nitrosothiols, which are able to provide local delivery of both nitric oxide and S-nitrosothiols by diffusion. This device is intended for coronary angioplasty applications with the purpose of inhibiting acute and chronic restenosis and refers to processes of stent coating with hydrophilic polymers containing incorporated S-nitrosothiols. This invention refers to an intracoronary implant device used in medical procedures, and introduces new S nitrosothiol-eluting stents coated with hydrophilic polymer multilayers. The hydrophilic polymers used for coating are polyvinyl alcohol, polyvinylpirrolidone and polyvinyl alcohol/polyvinylpirrolidone, polyvinyl alcohol/polyethylene glycol, polyvinylpirrolidone/polyethylene glycol and polyvinyl alcohol/polyvinylpirrolidone/polyethylene glycol blends.Type: ApplicationFiled: April 19, 2006Publication date: May 6, 2010Applicants: Universidade Estadual de Campinas UNICAMP, SCI-TECH Produtos Medicos LTDAInventors: Marcelo Ganzarolli de Oliveira, Alexander Marra Moreira, Amedea Barozzi Seabra, Maíra Martins de Souza Godoy Simões, Spero Penha Morato
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Publication number: 20100112095Abstract: The present invention relates to a bifunctional material which comprises copper and which is capable of storing nitric oxide (NO), as well as catalytically producing nitric oxide from a suitable precursor. The material typically includes a zeolite and the copper may be part of or separate from the zeolite. In this manner the material may include a single bifunctional material; that is, a material which is capable of both storing NO and catalytically producing NO, such as Cu-MFI or Cu—X. Alternatively the material may include at least two components, a first component to store NO, such as a zeolite Zn-LTA, and a further component including Cu(I), such as Cu2O, to catalytically produce NO from a suitable precursor. The bifunctional material may be used in a pharmaceutical, neutraceutical or cosmetic preparation, or comprised in a medical article, a cosmetic and/or personal hygiene product.Type: ApplicationFiled: November 19, 2007Publication date: May 6, 2010Inventors: Russel Edward Morris, Ian L. Megson
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Publication number: 20100111842Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: October 31, 2008Publication date: May 6, 2010Inventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
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Publication number: 20100104667Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: ApplicationFiled: September 21, 2009Publication date: April 29, 2010Applicant: GeNO LLCInventors: David H. Fine, David P. Rounbehler, Gregory Vasquez
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Publication number: 20100104665Abstract: Apparatus and methods deliver treatment agents simultaneously with capnic gases. The capnic gases can enhance the effectiveness of the treatment agent for treating rhinitis, lower the dosage of drug or concentration of agent necessary to achieve a therapeutic result, or both. Exemplary capnic gases include carbon dioxide, nitric oxide, nitrous oxide, and dilute acid gases.Type: ApplicationFiled: December 30, 2009Publication date: April 29, 2010Applicant: CAPNIA, INC.Inventors: Julia S. Rasor, Ned S. Rasor, Gerard F. Pereira
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Patent number: 7700135Abstract: Xenon or xenon-containing gases and, where appropriate, an NO source are employed as medicament for cerebral protection. Cerebral protection is defined as reducing or preventing impairments of cerebral function of various causes, but especially secondary to perfusion impairments of unclear etiology. The medicament can be used for cerebral protection for the prophylaxis of impairments of cerebral perfusion and for therapy after cerebral disorders have occurred, irrespective of the cause (e.g. cognitive, sensory or motor in nature).Type: GrantFiled: June 25, 2007Date of Patent: April 20, 2010Assignees: Air Liquide Deutschland GmbHInventors: Peter Neu, Carsten Pilger, Matthias Reyle-Hahn
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Publication number: 20100092441Abstract: Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a drop in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.Type: ApplicationFiled: February 26, 2008Publication date: April 15, 2010Inventors: Jon Lundberg, Eddie Weitzberg
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Patent number: 7678391Abstract: The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals.Type: GrantFiled: March 6, 2003Date of Patent: March 16, 2010Inventors: Charles H. Graham, Lynn-Marie Postovit, Michael A. Adams, Jeremy P. W. Heaton
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Publication number: 20100062059Abstract: The present invention refers to pharmaceutical compositions containing S-nitrosothiols as active principle. The referred compositions are intended for the treatment of the fatty liver disease and other diseases associated with the metabolic syndrome. The composition is administered either orally or rectally.Type: ApplicationFiled: April 20, 2007Publication date: March 11, 2010Applicant: PROTAGEN AKTIENGESELLSCHAFTInventor: Marcelo Ganzarolli De Oliveira
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Publication number: 20100055206Abstract: D-ribose is administered to patients suffering an acute myocardial infarction during first response care, in order to prevent cardiac compromise. In those patients able to ingest fluids, two to five grams of D-ribose is administered orally. In a patients unable to ingest fluids, or in a patient with and intravenous line, pyrogen-free D-ribose is administered intravenously at a rate of 50-300 mg/kg/hour.Type: ApplicationFiled: April 2, 2009Publication date: March 4, 2010Inventors: John A. St. Cyr, David J. Perkowski
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Publication number: 20100051025Abstract: Compositions and methods for preventing or reducing vasoconstriction in a mammal following administration of an artificial oxygen carrier (e.g., a hemoglobin-based oxygen carrier) are disclosed. The methods include administering to a mammal a composition containing an artificial oxygen carrier in combination with one or more of a nitric oxide-releasing compound, a therapeutic gas containing gaseous nitric oxide, a phosphodiesterase inhibitor, and/or a soluble guanylate cyclase sensitizer.Type: ApplicationFiled: November 6, 2007Publication date: March 4, 2010Applicant: The General Hospital CorporationInventors: Warren M. Zapol, Binglan Yu, Fumito Ichinose
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Publication number: 20100047210Abstract: Systems and methods for delivering a substance (e.g., a therapeutic or diagnostic substance, drug, biologic, cells, etc.) or device (e.g., implantable device, sensor, electrode, etc.) to a specific location within a tissue mass (e.g., an organ, tumor, other mass of body tissue, etc.) that is located a spaced distance from an open or fluid-filled space, body cavity or body lumen.Type: ApplicationFiled: August 25, 2008Publication date: February 25, 2010Applicant: Medtronic Vascular, Inc.Inventors: Jeremy Johnson, Aine Smalley
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Publication number: 20100043788Abstract: Various devices and methods for treating high-altitude sickness are disclosed herein. According to one embodiment, a handheld device delivers a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.Type: ApplicationFiled: August 13, 2009Publication date: February 25, 2010Inventors: David H. Fine, Gregory Vasquez, Bryan Johnson
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Publication number: 20100047344Abstract: The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.Type: ApplicationFiled: February 26, 2008Publication date: February 25, 2010Inventors: Jon Lundberg, Eddie Weitzberg
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Publication number: 20100040703Abstract: The present invention relates to uses, compositions, devices, and methods involving the utilisation of nitric oxide to hinder, impede, inhibit, or prevent transmission of infectious viral particles to host cells.Type: ApplicationFiled: August 12, 2009Publication date: February 18, 2010Inventors: Chris MILLER, Bruce MURRAY, Gilly REGEV-SHOSHANI
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Publication number: 20100021506Abstract: Gel strips containing reactants capable of reacting to form nitric oxide are maintained separate until application. Upon application, the gel strips are placed in contact with one another, and may mix, or operate by diffusion, to deliver nitric oxide directly to the stream of breathing air of a user. Adhesive strips bonded to a substrate supporting the gel strips may provide for securing the nitric oxide generator directly to an upper lip of a user for breathing the nitric oxide through the nostrils.Type: ApplicationFiled: January 28, 2009Publication date: January 28, 2010Inventor: Christie M. Jones
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Publication number: 20100016790Abstract: A device is provided that allows for treatment or pre-treatment of an area of a human or animal organ intended to be penetrated to connect the vascular system of said human or animal with a sampling, infusion, or withdrawal container. The device comprises nitric oxide (NO) for obtaining a vaso-dilating effect at said area during said treatment or pre-treatment.Type: ApplicationFiled: February 13, 2006Publication date: January 21, 2010Inventor: Tor Peters
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Publication number: 20100015253Abstract: Nitrogen oxide generating compositions are useful in the treatment of subungual infections, as NO has surprisingly been found to be able to penetrate the nail to exert an anti-fungal effect.Type: ApplicationFiled: May 28, 2009Publication date: January 21, 2010Inventor: Nigel Benjamin
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Publication number: 20100003349Abstract: An apparatus for portable delivery of nitric oxide without the need for pressurized tanks, power supplies, or other devices provides a single therapy session by triggering a heater to heat a reaction chamber. A piercing assembly may trigger to open sealed containers, such as bags, of liquid water or salt water in order to activate the heaters. Upon addition of liquid such as water or salt water to a chemically reactive heating element, heat is generated to activate the chemicals generating nitric oxide within a sealed reactor. Upon triggering, liquid containers are unsealed, the liquid drains down to initiate reaction of the heating chemicals, and the heat begins to penetrate the reactor. The reactor, in turn, heats its contents, which react to form nitric oxide expelled by the reactor to a line feeding a cannula for therapy.Type: ApplicationFiled: April 6, 2009Publication date: January 7, 2010Inventors: J. W. Randolph Miller, William Moon, Keith L. Merrell
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Publication number: 20090314289Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.Type: ApplicationFiled: January 28, 2009Publication date: December 24, 2009Inventors: David Fine, Gregory Vasquez, David P. Rounbehler
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Publication number: 20090317492Abstract: The use of liquid formulations in the preparation of a medicament for the prevention and treatment of oral, gastric and digestive infections and in particular for the prevention of ventilator associated pneumonia as well as liquid enteral and parenteral tube feeding compositions. The feeding compositions are suitable for use in the prevention of ventilator associated pneumonia.Type: ApplicationFiled: April 12, 2007Publication date: December 24, 2009Inventors: Robert Allaker, Charles Hinds, Arthur Tudor Tucker
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Publication number: 20090304802Abstract: A sustained release nasal formulation for delivery to a nasal cavity of a subject, wherein the formulation provides for sustained release of a substance, in particular nitric oxide (NO), to nasal mucosa within the nasal cavity so as to provide one or both of a therapeutic effect and promote normal nasal function, and a nasal delivery device and method relating thereto.Type: ApplicationFiled: March 5, 2007Publication date: December 10, 2009Applicant: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20090297576Abstract: Described herein are methods and medical devices used to deliver bioactive agents locally to patients in need of treatment and/or prevention of cardiovascular conditions Local delivery of protease-activated receptor 1 (PAR-1) antagonists are described herein from implantable medical devices including, but not limited to, stents.Type: ApplicationFiled: June 2, 2008Publication date: December 3, 2009Applicant: MEDTRONIC VASCULAR, INC.Inventors: Ayala Hezi-Yamit, Jennifer Wong
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Publication number: 20090297634Abstract: The invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous environment. The invention further provides methods of preparing the compositions and uses of the compositions for treating infections and disorders.Type: ApplicationFiled: June 20, 2007Publication date: December 3, 2009Inventors: Joel M. Friedman, Adam Friedman, Mahantesh S. Navati
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Publication number: 20090252816Abstract: The invention concerns the use of a gaseous mixture containing gas xenon and gas nitrous oxide, and advantageously oxygen, for making all or part of an inhalable medicine for preventing or treating neurointoxication in a human. The xenon/nitrous oxide mixture of the invention acts on one or more cerebral receptors to reduce the release and/or the effects of dopamine, glutamate, serotonin, taurin, GABA, noradrenaline and/or any other neurotransmitter. The proportion by volume of xenon of the mixture ranges between 5 and 45%, and the proportion by volume of nitrous oxide ranges between 10 and 50%, the balance is preferably oxygen.Type: ApplicationFiled: April 2, 2009Publication date: October 8, 2009Applicant: AIR LIQUIDE SANTE (INRTERNATIONAL)Inventors: Jacques Abraini, Marc Lemaire
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Publication number: 20090246296Abstract: Nitroxyl donating compounds are administered prior to the onset of ischemia for the prevention and/or reduction of ischemia/reperfusion injury in subjects at risk for ischemia. Nitroxyl donors also are administered to organs to be transplanted for the prevention and/or reduction of ischemia/reperfusion injury upon reperfusion in a recipient. Nitroxyl donors include any nitroxyl donating compound. In particular cases the nitroxyl donor is a nitroxyl-donating diazeniumdiolate, such as Angeli's salt or IPA/NO.Type: ApplicationFiled: December 30, 2008Publication date: October 1, 2009Inventors: David A. Wink, Martin Feelisch, Pasquale Pagliaro, David A. Kass, Nazareno Paolocci, Katrina M. Miranda, Jon M. Fukuto
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Publication number: 20090238815Abstract: Disclosed are nondegradable hydrogels used to coat or form at least a portion of a medical device. The hydrogels may be formed from functionalized PEG based macromers. These hydrogels are easy to sterilize, transport and store. Methods of forming these hydrogels as described herein are included.Type: ApplicationFiled: March 18, 2008Publication date: September 24, 2009Applicant: Medtronic Vascular, Inc.Inventors: Kishore Udipi, Julie Trudel, Ya Guo
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Publication number: 20090232863Abstract: Disclosed herein are implantable medical devices coated with or comprising bioabsorbable carbon-based nitric oxide-donating polymers that upon exposure to physiological environments donate nitric oxide (NO).Type: ApplicationFiled: March 17, 2008Publication date: September 17, 2009Applicant: Medtronic Vascular, Inc.Inventors: Peiwen Cheng, Kishore Udipi, Mingfei Chen
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Publication number: 20090232909Abstract: NO preferentially binds to the minor population of the hemoglobin's vacant hemes in a cooperative manner, nitrosylates hemoglobin thiols, or reacts with liberated superoxide in solution. The distribution of minor forms of hemoglobin can be tested and the results can be used to predict whether a composition of hemoglobin will scavenge, load, eliminate, or donate NO. Hemoglobin thus serves to regulate the chemistry of NO. SNO-hemoglobin transfers NO equivalents to the red blood cell anion transport protein AE1, which serves to export NO from red blood cells. Regulation of AE1 function is the basis for methods of therapy to affect levels of NO or its biological equivalent.Type: ApplicationFiled: April 11, 2008Publication date: September 17, 2009Inventors: Jonathan S. Stamler, Andrew J. Gow, David J. Singel
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Publication number: 20090226504Abstract: A intravascular, interstitial or intraorgan medical device, and a manufacturing process of said medical device, is provided that allows for prevention of infection and obtainment of anti-thrombotic effect. The medical device comprises a nitric oxide (NO) eluting polymer arranged adjacent mammal tissue, such that a therapeutic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said mammal tissue. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO). Furthermore, a manufacturing method for said device is disclosed.Type: ApplicationFiled: February 13, 2006Publication date: September 10, 2009Applicant: NOLabs ABInventor: Tor Peters
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Publication number: 20090214618Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.Type: ApplicationFiled: May 30, 2006Publication date: August 27, 2009Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
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Publication number: 20090214674Abstract: The present invention relates to methods for promoting dispersal of, or preventing formation of microbial biofilms, comprising: exposing a biofilm to an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; treating a surface or medium susceptible to biofilm formation with an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; incorporating an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent in a surface or medium susceptible to biofilm formation; or inducing the accumulation of one or more reactive oxygen or nitrogen species within microorganisms within said biofilm or capable of forming a biofilm. The invention also relates to methods for maintaining or enhancing or maintaining and enhancing the functioning of a biofilm, comprising exposing a biofilm to at least one nitric oxide scavenger, at least one antioxidant or at least one nitric oxide scavenger and at least one antioxidant.Type: ApplicationFiled: May 24, 2006Publication date: August 27, 2009Inventors: Nicolas Louis Gabriel Barraud, Jeremy Stephen Webb, Scott Alan Rice, Lars Ake Staffan Kjelleberg
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Publication number: 20090214624Abstract: The present invention is related to topical nitric oxide delivery systems, and to using the same for mitigating or remediating various disease states The present invention is also related to using topical nitric oxide delivery systems for enhancing blood flow.Type: ApplicationFiled: November 29, 2005Publication date: August 27, 2009Applicant: THE UNIVERSITY OF AKRONInventors: Daniel J. Smith, Marco Lopez, Patricio Lopez-Jaramillo
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Publication number: 20090202617Abstract: This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.Type: ApplicationFiled: February 13, 2009Publication date: August 13, 2009Inventors: Kevin R. Ward, Robert Diegelmann, Bruce Spiess, Gary S. Huvard, Gurbhagat S. Sandhu, Gary Bowlin, Chris Stern
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Publication number: 20090196930Abstract: Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.Type: ApplicationFiled: December 24, 2008Publication date: August 6, 2009Applicant: Aires Pharmaceuticals, Inc.Inventors: Mark W. Surber, Gary T. Elliott, Geoffrey Eugene Barker
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Publication number: 20090191284Abstract: The present disclosure relates to the use of a nitroaniline derivative of Formula (I) for the production of nitric oxide and for the preparation of a medicament for the treatment of a disease wherein the administration of nitric oxide is beneficial. The present disclosure furthermore relates to a method for the production of NO irradiating a nitroaniline derivative of Formula (I), a kit comprising a nitroaniline derivative of Formula (I) and a carrier and to a system comprising a source of radiations and a container associated to a nitroaniline derivative of Formula (I). In Formula (I), R and RI are each independently hydrogen or a C1-C3 alkyl group; RII is hydrogen or an alkyl group.Type: ApplicationFiled: January 26, 2009Publication date: July 30, 2009Applicant: STMicroelectronics S.r.I.Inventors: Sabrina Conoci, Salvatore Petralia, Salvatore Sortino
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Publication number: 20090191281Abstract: Use, method of manufacturing a pharmaceutical composition, pharmaceutical composition for the treatment of skin ailments comprising a therapeutic quantity in aqueous solution of nitric acid of 5 to 15 mmol/ml of pharmaceutical composition, and also comprising a zinc salt at a concentration of 0.01 to 0.015 mg of Zn2+ ions/ml as well as a copper salt at a concentration of 0.01 to 0.015 mg of Cu2+ ions/ml of pharmaceutical composition and its medical device.Type: ApplicationFiled: January 23, 2009Publication date: July 30, 2009Applicant: AURIGA INTERNATIONALInventor: Alfred MARCHAL