Abstract: The present invention is related to the novel oral dosage form for sustained release of crocin-1, a active constituent of Crocus sativus extract or fraction and a process for preparing the same wherein the extract is wet-granulated using excipients, biodegradable polymers and/or non-biodegradable polymers alone or in combination. The said formulations are useful for the treatment of chronic inflammatory diseases wherein NLRP3 inflammasome is involved.

Abstract: The present specification relates to a composition for preventing, alleviating or treating burnout syndrome, containing a natural extract as an active ingredient. According to one aspect of the present invention, the composition contains a ginseng fruit extract, and thus is useful for preventing, treating and alleviating burnout syndrome. In addition, according to one aspect of the present invention, the composition further contains ginseng fruit and one or more selected from the group consisting of red ginseng, Angelica gigas, Cornus officinalis, Cervi parvum corni, and Nigella sativa, so as to maximize the synergistic effect among two or more ingredients, thereby exhibiting excellent effects on the prevention, treatment and alleviation of burnout syndrome. Therefore, there is an advantage of making individuals and society mentally and physically healthy since burnout syndrome can be prevented, treated and alleviated, by using the composition of the present invention.

Abstract: The present disclosure belongs to the technical field of health care products or foods and provides the use of a ginseng alcohol extract in sleep-promoting health care products or foods. Through analysis utilizing DAM2 drosophila behavior monitoring system, it is found that the ginseng alcohol extract can increase total sleep duration of normal and sleep deprived drosophilae, and relieve sleep rhythm disorder caused by sleep deprivation. Through a climbing experiment, it is found that the ginseng alcohol extract can improve the climbing ability of normal and sleep deprived drosophilae. The ginseng alcohol extract, on the one hand, improves the quality of sleep to protect the steady state of sleep rhythm, and on the other hand, increases the motive ability after sleep. The ginseng alcohol extract of the present disclosure is intended to be used to sleep-promoting health care products or healthy foods and improve the quality of sleep.

Abstract: A composition comprising a grape seed extract and a black tea extract. The composition can increase testosterone secretion more effectively than a single component, and can be used for preparing pharmaceutical compositions, foods, health foods, dietary supplements or drinks used for promoting testosterone secretion.

Abstract: The present disclosure relates to an infusion product for making a beverage, such as a tea or tea-like drink. In order to produce the composition of the present disclosure, plant materials are contacted with a solvent to remove an extract. The remaining plant materials are then formed into a fibrous structure or network, such as a sheet or fibrous layer. The extract may be further treated or concentrated and then reapplied to the plant materials. In accordance with the present disclosure, the resulting sheet or layer is then reduced to discrete pieces having a unique particle size distribution. Through the process of the present disclosure, a composition is produced that not only has a minimal amount of fines and dust, but can also have a relatively low bulk density.

Abstract: A composition for sebum control and pore reduction, and its use for controlling sebum and reducing pore of skin are disclosed. The external-use skin preparation composition contains, as an active ingredient, extracts of one or more medicinal herbs selected from the group consisting of Cimicifugae rhizoma, Solani nigri herba, Glycyrrhiza uralensis, Clematis mandshurica, Acanthopanax senticosus, Inulae radix and Dioscorea japonica, and thus it not only can control the production of sebum and alleviate skin troubles, but also provide antioxidant effects, prevent pore enlargement, or prevent occurrence of skin irritation.

Abstract: A composition for topical application containing at least one combination of (a) polyphenols selected from proanthocyanidin monomers and oligomers (OPC), hydroxystilbenes, flavonoid monomers and oligomers, and derivatives and mixtures thereof, (b) a spruce extract having at least one lignan selected from: hydroxymatairesinol, secoisolariciresinol, conidendrin, lariciresinol and liovile. It also relates to the cosmetic use of such a combination for combating the signs of ageing of the skin or hair and nails or the effects of pollution, and a cosmetic treatment method using said combination.

Abstract: A use of ginsenoside M1 for manufacturing a medicament for treating oral cancer.

Abstract: A composition, a health functional food or a treatment method of the present invention has a remarkable cranial nerve cell protection effect and simultaneously has a sensorimotor function recovery promotion effect and a body weight increasing effect. Accordingly, the present invention has effects of preventing stroke or neurodegenerative diseases, protecting cranial nerve cell cells over the mid to long term immediately after the onset of disease, promoting the recovery of a sensorimotor function reduced by stroke and neurodegenerative diseases, and increasing a reduced body weight. Therefore, the present invention can be used for effectively preventing, treating or managing stroke and neurodegenerative diseases.

Abstract: Disclosed is a composition, which comprises Hordeum vulgare extract as an active ingredient and is effective at promoting longitudinal bone growth.

Abstract: The present invention relates to bioactive compositions (including, for example, bioactive serum fractions and bioactive extracts) derived from ginseng (Panax spp.) fresh whole plant, a particular part of the plant (e.g., rhizome, roots, leaves, stems, flowers, fruit) or any combination of these plant parts. The bioactive serum fractions and bioactive extracts are free of or substantially free of pulegone and/or free of or substantially free of proteins. The present invention also provides products comprising the bioactive serum fractions and/or bioactive extracts. The present invention further provides methods of making and using the bioactive serum fractions and/or bioactive extracts. Further, the bioactive serum fractions and bioactive extracts have anti-inflammatory and/or anti-irritant and/or anti-aging activities.

Abstract: Provided are a use of chlorogenic acid in preparing pharmaceuticals for the inhibition of LAG-3 and a use of chlorogenic acid in preparing pharmaceuticals for the treatment of LAG-3-mediated diseases. The inhibition of LAG-3 by chlorogenic acid is useful in cancer therapy, anti-viral therapy, and sepsis treatment. The oral bioavailability of chlorogenic acid is enhanced by preparing chlorogenic acid as a gastric floating tablet.

Abstract: The present invention relates to a composition comprising an araloside-based compound and, more particularly, to a composition for external application to skin, the composition comprising, as an active component, an araloside-based compound, including araloside X, araloside V and araloside VII. Thus, the composition restores skin markers damaged by external environmental stress, such as harmful substances or fine dusts, and reduces the expression of skin inflammatory factors to help the recovery of damaged skin, thereby providing effects, such as anti-oxidation, skin trouble suppression, anti-inflammation, or skin barrier improvement.

Abstract: Composition for strengthening the immune system and method of preparation of the same are disclosed herein. The disclosed herbal composition includes gold particles and honey which facilitate in boosting the immune system and overall health. It is believed to improve the physical and mental health of an individual. The disclosed composition is instrumental as immune stimulating and memory boosting agent.

Abstract: An auricular cleaning composition includes isopropylic alcohol and/or diethylene glycol monoethyl ether as ceruminolytic agent(s), optionally in combination with caprylocaproyl polyoxyl-8 glyceride.

Abstract: The present invention provides a gelling composition for preparing a gelatinous food which do not dissolve even when reheated (e.g., dysphagia diet). The present invention provides a gelling composition for preparing a gelatinous food which retains its original shape even when reheated, wherein the gelling composition comprises a water-soluble polymer capable of forming a thermo-irreversible gel. Also provided is a method of gelling a food and enhancing the shape-retaining property of the food against reheating by using the above-described gelling composition, as well as a method of preparing a gelatinous food which retains its original shape even when reheated by using the above-described gelling composition.

Abstract: Disclosed are a method for preparing a ginseng polysaccharide for immune stimulation and a ginseng polysaccharide for immune stimulation prepared from the preparation method, the method comprising the steps of (1) adding ingredients; (2) performing an extraction; (3) performing a first filtration and cooling; (4) performing a second filtration; (5) performing a first concentration; (6) adding a concentrate to a fermentation alcohol; (7) separating into a supernatant and a precipitate; (8) collecting the precipitate; (9) dissolving in water; (10) performing a second concentration; (11) cold ageing; (12) performing a third concentration; (13) sterilizing; and (14) packaging into a product of the ginseng polysaccharide for immune stimulation in the form of a concentrate.

Abstract: Provided are a pharmaceutical composition for preventing and/or treating osteoarthritis comprising an extract of Angelica gigas Nakai, a pharmaceutical composition for preventing and/or treating osteoarthritis comprising a mixed extract of Angelica gigas Nakai and Cnidium officinale, and a method of preventing and/or treating osteoarthritis comprising administering the extract of Angelica gigas Nakai or the mixed extract of Angelica gigas Nakai and Cnidium officinale.

Abstract: The present invention relates to a composition comprising the mixed extract of mulberry and Poria cocos peel for preventing, improving or treating neurodegenerative disorders. The mixed extract of mulberry and Poria cocos peel which is the active ingredients contained in the composition of the present invention, has a memory improving activity through inhibiting of acetylcholine esterase and a neuroprotective effects and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

Abstract: Provided is a treatment composition for damage treatment and regeneration promotion of corneal epithelial cells containing gintonin as an active ingredient which is glycolipoprotein or its aggregate isolated from ginseng. Since the gintonin as a drug containing high-concentration LPA has an effect of increasing the concentration of LPA in damaged cornea and inducing the proliferation of corneal epithelial cells to rapidly and significantly restore the damage of the cornea, the composition of the present disclosure can be usefully used as drugs for treatment of corneal erosion and corneal ulcer or equivalent therapeutic agents for corneal injury in humans and animals.

Abstract: The present invention describes the use of the Chinese medicinal compounds ginsenoside RB1, dihydromyricetin and salvianohc acid B, for use in diagnosing, monitoring and treating synucleinopathies, such as Parkinson's disease, in patients.

Abstract: The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.

Abstract: The present disclosure provides a method for preparing an anti-wrinkle functional cosmetic substance comprising cutting herbal materials comprising Angelica gigas root, Rehmannia glutinosa root, a paeonia albiflora root, Mentha arvensis, Angelica dahurica root, Scrophularia buergeriana, Rheum undulatum root/stalk/stem, Sanguisorba officinalis root, and Cinnamomum cassia bark into pieces, putting a mixture of the herbal material pieces, talc, a pearl powder, deep ocean water into an extractor, sterilizing the mixture, then fermenting the mixture by mixed lactobacillales strain, and then hot-water extracting the mixture into a solid, freeze-drying the extracted solid into a freeze-dried powder, and dissolving and high-speed mixing the freeze-dried powder, adenosine, and borax in a beeswax, a perilla oil, an Olea europaea (olive) fruit oil, and a Helianthus annuus (sunflower) seed oil heated and Chamaecyparis obtusa water heated.

Abstract: Provided is a method of treating ovotoxicity of an individual, including administering an Ulmi cortex extract to an individual in need of treatment. The present disclosure may exhibit an effect of preventing, alleviating, or treating ovarian aging or premature ovarian failure by inhibiting oxidative stress or ovotoxicity of the ovaries.

Abstract: The present invention relates to a pharmaceutical composition containing ginsenoside F1 or Rh1 for preventing or treating vascular leak syndrome, to a method for treating vascular leak syndrome using the pharmaceutical composition, and to a food composition containing ginsenoside F1 or Rh1 for preventing or ameliorating vascular leak syndrome. The ginsenoside F1 or Rh1 provided in the present invention can promote angiogenesis and suppress vascular leakage, and thus can be widely utilized in the effective prevention or treatment of vascular leak syndrome.

Abstract: The present invention features a composition and method for suppressing appetite. The composition of the invention is composed of yerbe maté extract, guarana extract, and damiana extract in combination with a dietary fiber.

Abstract: Disclosed herein are methods for treating mammals with HIV/AIDS comprising administering a therapeutically effective amount of a composition comprising an extract of Rubia cordifolia. The extract is preferably an alcohol extract, an aqueous extract, or mixtures thereof. The alcohol preferably comprises ethanol, isopropyl alcohol, or mixtures thereof.

Abstract: A nutritional supplement composition and associated method enhances working and long term memory support in a healthy adult person, and includes a Panax Ginseng extract and Ginkgo Biloba extract in a ratio a:b, wherein a for the Panax Ginseng extract is between about 1.9 and 2.8 and b for the Ginkgo Biloba extract is between bout 0.8 and 1.1. It is formulated for oral administration such that the Panax Ginseng extract and Ginkgo Biloba extract together account for at least 90 wt % of a dosage unit of the nutritional supplement composition. The Panax Ginseng extract and Ginkgo Biloba extract together may be present in the amount from about 320 mg to 960 mg. The dosage unit of the composition may be equal to or less than about 1,000 mg.

Abstract: There is disclosed the use of a composition for promoting neuronal growth of neurons in tissues of the central or peripheral nervous system. There is also disclosed a method for inducing proliferation or differentiation of neuronal cells.

Abstract: The present invention relates to a ginseng mixed composition with improved bioavailability of saponin. Further, the present invention relates to a method for improving saponin bioavailability of a subject comprising: administering to the subject an effective amount of at least one extract selected from a Schizandra chinensis extract and a Liriope platyphylla extract that improves saponin bioavailability in the subject.

Abstract: The present invention discloses a new use of ginsenoside M1 for treating or preventing gout.

Abstract: Certain embodiments are directed to oridonin analogs or derivatives. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents.

Abstract: The present invention relates to a composition for preventing or treating neurological diseases including an extract of Euphoria longan fruit, red sage and Gastrodia elata as an active ingredient. The composition of the present disclosure has a superior effect of inhibiting the activity of acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine directly involved in impairment of cognitive function. In addition, the composition of the present disclosure is safe for the human body since the biologically safe extract of Euphoria longan fruit, red sage and Gastrodia elata is used as the active ingredient.

Abstract: The present invention discloses a PPAR ?/? dual agonist and its application. The PPAR ?/? dual agonist comprises an effective amount of the compounds represented by formula I or/and its pharmaceutically acceptable derivative. Wherein. R1 is selected from alkoxyl or ester group; R2 is selected from hydroxyl or ester group. The PPAR ?/? dual agonist according to the present invention can be used for preparing drugs and functional foods for preventing or/and treating metabolic syndrome, especially glucose or/and lipid disorders, with extensive and bright prospects of application.

Abstract: An extract from leaves of mulberry is disclosed. The extract has an IC50 value sufficient to inhibit ?-glucosidase I. The extract may comprise 5-40% (w/w) total imino sugars and 20-70% (w/w) total amino acids. The extract may reduce the production of melanin for the treatment of such ailments or diseases caused by pigmentation as freckle, chloasma, striae gravidarum, sensile plaque and melanoma. The extract may also control blood glucose level.

Abstract: A prescription of intravenous medication and its treatment method block heroin or morphine intoxication. The prescription of intravenous infusion includes Cerebrolysin, Piracetam, Cimetidine, Scopolamine Butylbromide, Nefopam, B.C Complex, Vitamin B1, Ascorbic Acid, Ketorolac, Guronsan, Hyoscine Butylbromide and Sukerin. The prescription activates a patient's liver and circulatory system to block drug intoxication. The treatment method for blocking drugs includes an acute withdrawal part, with the prescription of intravenous infusion injected and with the timing of drug administration and the safe dosage controlled according to clinical symptoms. An appropriate amount of a supplementary medicine such as Haloperidol is added, and the processes of detoxication, relieving symptoms, suppressing restlessness, and sobering are conducted to block acute withdrawal symptoms of an acute withdrawal addict quickly and successfully.

Abstract: Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total ginsenosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

Abstract: The invention relates to a method for production of a preparation from a vegetable material, said preparation being enriched in a polysaccharide with a backbone comprising rhamnogalacturonan-I cores, said method comprising the steps: mixing the vegetable material with a polar alcoholic solvent; and separating a solid residue obtained in step a) from the solvent; and mixing the solid residue obtained in step b) with a buffered aqueous solution having a pH between 7 and 8. Also provided is a preparation containing rhamnogalacturonan-I pectins that can be obtained by this method and the use of such a preparation to modulate immune response.

Abstract: Composition comprising an anti-inflammatory plant extract from rosehips together with a cartilage-protective substance, and a method of producing the rosehip extract.

Abstract: Disclosed is a composition for enhancing alcohol metabolism in a subject, who overdrank, the composition comprises an effective amount of ginsenoside-free extract of steam-dried Korean ginseng berry (GFM) and one or more pharmaceutically or sitologically acceptable carriers. The composition of the present disclosure may be effective for alleviating hangover according to overdrink and for protecting liver from alcoholic injure.

Abstract: Disclosed are compositions containing: a) Phaseolus vulgaris extract; b) Cynara scolymus extract; c) Echinacea angustifolia extract; d) Vitis vinifera extract and optionally e) Panax ginseng extract, mixed with suitable excipients.

Abstract: The present invention provides a composition comprising Astragali Radix extract as an active ingredient. The composition can increase body energy consumption and muscle metabolism. The present invention also relates to pharmaceutical and food compositions which include a composition comprising the Astragali Radix extract. The pharmaceutical and food compositions also increase body energy consumption and muscle metabolism.

Abstract: The present invention relates to a composition for preventing or treating dementia containing an extract of Prunus mume (Fructus Mume), and the Prunus mume extract of the present invention has outstanding effects in improving spatial recognition ability and in normalizing hippocampal damage (normalizing ERK phosphorylation, increasing ChAT and normalizing NF-kappa B) induced by chronic vascular brain damage in a vascular dementia animal model, and hence can be used to advantage as a medicinal product for preventing or treating dementia diseases and as a functional health food for preventing or alleviating dementia diseases that accompany vascular brain damage such as vascular dementia.

Abstract: The present invention features a composition and method for reducing food intake. The composition of the invention is composed of yerbe maté extract, guarana extract, and damiana extract in combination with a dietary fiber.

Abstract: A composition including Cuscuta japonica Choisy extract, or the extract of Rehmannia glutinosa Libschitz var. purpurea MAKINO and Cuscuta japonica Choisy is provided. The composition, which can be a pharmaceutical or food composition, is useful for preventing, ameliorating, or treating hearing loss. A method for ameliorating, preventing, or treating hearing loss, in particular, acoustic trauma, temporary or permanent hearing loss by effectively inhibiting the threshold shift induced by noise and the likes is disclosed.

Abstract: Compounds having unique properties are prepared from the herbal compositions described herein and comprise extracts derived from plants and fungi of the genera Panax, Ganoderma, and Saussurea. The compositions are useful in preventing, treating, relieving, and improving the quality-of-life of patients suffering from chronic diseases, such as liver diseases, cancer, cachexia, and immune system disorders.

Abstract: A polylactic polyester resin having a chemical structure represented by Formula (1), an acid value of 300 to 2,500 eq/106 g, a number average molecular weight of 2,000 to 50,000, and a lactic acid content percentage of not less than 40 weight %, Z—(O—(CH2CH2O)p—(CO—Y—O)q—X)r??(1) wherein Z is an r-valent organic group, Y is —CH(CH3)—, or a mixture of —CH(CH3)— and C2-10 linear or branched alkylene group, and X is a residue of a polybasic acid having 2 or more carboxyl groups, or hydrogen; each of X, Y, and Z may be one kind or a mixture of a plurality of different kinds; and p, q, and r are 0 or a positive integer, p has an average value of not less than 0.5, q has an average value of not less than 5, and r has an average value of not less than 3 and not more than 15.

Abstract: Provided is a 15-PGDH activity adjusting function of a Dendropanax morbifera extract. More specifically, since it has been confirmed that the Dendropanax morbifera extract has an outstanding effect in suppressing 15-PGDH activity and so increasing PGE2, a composition of the present invention which contains the Dendropanax morbifera extract as an active ingredient has the advantage of being able to be used for producing a functional health food and a therapeutic agent for a disease associated with PGE2.

Abstract: Some implementations provide a method for treating urological disorders in a patient, the method including: placing an introducer into a patient's body through an incision site on the patient's body, the patient suffering from an urological disorder; placing an implantable wireless device into an inner lumen of the introducer, the implantable wireless device suitable to fit into the inner lumen and configured to receive electromagnetic energy non-inductively from a source located outside the patient's body; through the inner lumen of the introducer, positioning the implantable wireless device adjacent to or near one or more excitable tissue in the patient, the one or more excitable tissue regulating a nerve activity associated with the urological disorder; and causing neural modulation of the one or more excitable tissue through one or more electrodes on the implantable wireless device.

Abstract: Disclosed is a cosmetic or dermatological preparation that is obtainable by combining collagen and/or a derivative thereof, chitosan and/or a derivative thereof, glycosylaminoglycan and/or a derivative thereof with a peptide that is capable of promoting skin cell growth and/or with a composition which comprises glycoproteins 1 and 2 and ginseng and horsetail extracts.